enkephalin, ser(2), leu(5), thr(6)- has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 102 studies
Studies (enkephalin, ser(2), leu(5), thr(6)-) | Trials (enkephalin, ser(2), leu(5), thr(6)-) | Recent Studies (post-2010) (enkephalin, ser(2), leu(5), thr(6)-) | Studies (enkephalin, ala(2)-mephe(4)-gly(5)-) | Trials (enkephalin, ala(2)-mephe(4)-gly(5)-) | Recent Studies (post-2010) (enkephalin, ala(2)-mephe(4)-gly(5)-) |
---|---|---|---|---|---|
224 | 0 | 5 | 151 | 0 | 71 |
224 | 0 | 5 | 2,727 | 1 | 374 |
Protein | Taxonomy | enkephalin, ser(2), leu(5), thr(6)- (IC50) | enkephalin, ala(2)-mephe(4)-gly(5)- (IC50) |
---|---|---|---|
Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.003 | |
Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.003 | |
Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.003 | |
Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.003 | |
Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.003 | |
Delta-type opioid receptor | Mus musculus (house mouse) | 1.2415 | |
Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0132 | |
Mu-type opioid receptor | Homo sapiens (human) | 0.004 | |
Delta-type opioid receptor | Homo sapiens (human) | 0.0014 | |
Mu-type opioid receptor | Mus musculus (house mouse) | 0.0048 | |
Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0283 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 27 (26.47) | 18.7374 |
1990's | 62 (60.78) | 18.2507 |
2000's | 8 (7.84) | 29.6817 |
2010's | 5 (4.90) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Daugé, V; Delay-Goyet, P; Gacel, G; Roques, BP; Zajac, JM | 1 |
Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
Grossman, A; Hucks, D; Joel, SP; McLoughlin, L; Patel, N; Rees, LH; Slevin, ML; Thompson, PI | 1 |
Borsodi, A; Búzás, B; Cavagnero, S; Hruby, VJ; Tóth, G | 1 |
Childers, SR; Fleming, L; Konkoy, C; Marckel, D; Pacheco, M; Sexton, T; Ward, S | 1 |
Olianas, MC; Onali, P | 1 |
Il'ina, AD; Iukhananov, RIu; Klodt, PM; Varfolomeev, SD; Zaĭtsev, SV | 1 |
Fan, LQ; Hiller, JM; Ofri, D; Simon, EJ | 1 |
Childers, SR; Nijssen, PC; Sexton, T | 1 |
Chung, NN; Lemieux, C; Nguyen, TM; Schiller, PW; Weltrowska, G; Wilkes, BC | 1 |
Barnard, EA; Demoliou-Mason, C; Richardson, A | 1 |
Hiller, JM; Simon, EJ; Stein, EA | 1 |
Bhargava, HN; Gulati, A | 1 |
Bunn, SJ | 1 |
Gudehithlu, KP; McDonald, JS; Rattan, AK; Tejwani, GA | 1 |
Bunn, SJ; Dunkley, PR | 1 |
Bodnar, RJ; Kepler, KL; Kest, B; Pasternak, GW; Paul, D; Standifer, KM | 1 |
Helme, RD; Khalil, Z | 1 |
Billington, CJ; Grace, M; Levine, AS; Portoghese, PS | 1 |
Henderson, G; Rogers, H | 1 |
Hanissian, SH; Tejwani, GA | 1 |
La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 1 |
Krekhnov, BV; Kurochkin, IN; Skliankina, OA; Varfolomeev, SD; Varfolomeeva, AD; Zaĭtsev, SV | 1 |
Fan, LQ; Hiller, JM; Simon, EJ | 2 |
Billington, CJ; Gosnell, BA; Grace, M; Levine, AS | 1 |
Bidlack, JM; Selley, DE | 1 |
Bhargava, HN; Gulati, A; Ramarao, P | 2 |
Bodnar, RJ; Gistrak, MA; Pasternak, GW; Paul, D | 1 |
de Castiglione, R; Guglietta, A; Lazarus, LH; Wilson, WE | 1 |
Hoffman, PL; Khatami, S; Salafsky, B; Shibuya, T | 1 |
Bockaert, J; Eybalin, M; Pujol, R | 1 |
Gauthier, S; Magnan, J; Pilapil, C; Quirion, R; Welner, S | 1 |
Bhargava, HN; Collins, BJ; Rapaka, RS; Renugopalakrishnan, V | 1 |
Crema, G; Gioannini, TL; Hiller, JM; Simon, EJ | 1 |
Cox, BM; Puttfarcken, PS; Werling, LL | 1 |
Bhargava, HN; Rapaka, RS; Renugopalakrishnan, V | 1 |
Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
Gosnell, BA; Levine, AS; Morley, JE | 1 |
Gosnell, BA; Grace, M; Levine, AS | 1 |
Clark, JA; Houghten, R; Pasternak, GW | 1 |
Johnson, DR; Oleson, DR | 1 |
Boudouresque, F; Bourhim, N; Cantau, P; Castanas, E; Giraud, P; Oliver, C | 1 |
Coletti-Previero, MA; Descomps, B; Martin, JL; Roques, BP | 1 |
Lemieux, C; Maziak, LA; Nguyen, TM; Schiller, PW | 1 |
Brown, SR; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
Itzhak, Y; Pasternak, GW | 1 |
Akil, H; Khachaturian, H; Lewis, ME; Mansour, A; Watson, SJ | 1 |
Heyman, JS; Mosberg, HI; Omnaas, JR; Porreca, F; Vaught, JL | 1 |
Belknap, JK; Laursen, SE | 1 |
Chiappinelli, VA; Feng, C; McMahon, LL; Wolf, KM; Yum, L | 1 |
Fukushima, N; Hayashi, C; Katayama, T; Misu, Y; Miyamae, T; Ueda, H | 1 |
Cupo, A; Garreau, I; Pejoan, C; Piot, JM; Zhao, Q | 1 |
Dragatsis, I; Gerozissis, K; Papazafiri, P; Zioudrou, C | 1 |
Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Petit, A | 1 |
Angelopoulos, E; Koutsoukos, E; Maillis, A; Stefanis, C; Zioudrou, C | 1 |
Barannik, VL; Lishmanov, IuB; Maslov, LN; Ugdyzhekova, DS | 1 |
Il'Ina, AD; Klodt, PM; Maisky, AI; Zaitsev, SV | 1 |
Búzás, B; Cox, BM; Izenwasser, S | 1 |
Barnard, EA; Benyhe, S; Borsodi, A; Simon, J; Wollemann, M | 1 |
Barg, J; Belcheva, M; Burke, WJ; Chung, HD; Coscia, CJ; Ho, A; Rowinski, J; Schmidt, CA | 1 |
Loukas, S; Mercouris, M; Panetsos, F; Zioudrou, C | 1 |
Fukushima, N; Misu, Y; Miyamae, T; Ueda, H | 1 |
Lanthorn, TH; Watson, GB | 1 |
Howells, RD; Jin, J; Shahrestanifar, M; Wang, WW | 1 |
Howells, RD; Shahrestanifar, M; Wang, WW | 1 |
Maliukova, IV; Metaksa, EE; Zakharova, LA | 1 |
Cox, BM; Stevens, BA; Tang, T | 1 |
Fujimoto, JM; Rady, JJ | 1 |
Bakogeorgou, E; Castanas, E; Hatzoglou, A | 1 |
Christensen, CB; Christrup, LL; Kristensen, K; Nielsen, LC | 1 |
Kodama, H; Kondo, M; Motoyama, S; Nose, T; Shimohigashi, Y; Yasunaga, T | 1 |
Fan, LQ; Hiller, JM | 1 |
Kampine, JP; Mizoguchi, H; Narita, M; Tseng, LF | 1 |
Breivogel, CS; Childers, SR; Selley, DE | 1 |
Billington, CJ; Kotz, CM; Levine, AS | 1 |
Ingram, S; McCleskey, EW; Wilding, TJ; Williams, JT | 1 |
Childers, SR; Sim, LJ | 1 |
Cheĭdo, MA; Idova, GV | 1 |
Kramer, HK; Simon, EJ | 2 |
Liu, H; Mazarati, A; Wasterlain, C | 1 |
Chen, J; Chi, ZQ; Li, GE; Pei, G; Wang, CH; Zhou, DH | 1 |
Bebiakova, NA; Mikhaĭlova, SD; Semushkina, TM; Sokolov, AV; Storozhakov, GI | 1 |
Malyukova, IV; Molotkovskaya, IM; Zakharova, LA | 1 |
Bakalkin, G; Derjabin, V; Hauser, KF; Nazarevskaja, G; Reznikov, K; Trunova, Y | 1 |
Borsodi, A; Medzihradszky, K; Orosz, G; Szatmári, I | 1 |
Inoue, M; Ueda, H | 1 |
Glushchenko, NV; Mikhailova, SD; Semushkina, TM; Storozhakov, GI | 1 |
Lishmanov, AY; Maslov, LN; Rebrova, TY; Tam, SV | 1 |
Lishmanov, IuB; Maslov, LN; Rebrova, TIu; Tam, SV | 1 |
Schomburg, ED; Steffens, H; Wada, N | 1 |
Martin-Kleiner, I | 1 |
Burda, IuE; Liashev, IuD | 1 |
Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K | 1 |
Dibaj, P; Schomburg, ED; Steffens, H | 1 |
Lyashev, YD; Solin, AV | 3 |
Lyashev, AY; Lyashev, YD; Solin, AV | 1 |
102 other study(ies) available for enkephalin, ser(2), leu(5), thr(6)- and enkephalin, ala(2)-mephe(4)-gly(5)-
Article | Year |
---|---|
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Mice; Muscle Contraction; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 1988 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Morphine; Morphine Derivatives; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Subcellular Fractions | 1992 |
Synthesis and binding characteristics of the highly delta-specific new tritiated opioid peptide, [3H]deltorphin II.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indicators and Reagents; Isotope Labeling; Kinetics; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1992 |
Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Imidodiphosphate; Analgesics; Animals; Brain; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Neurons; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; RNA, Messenger | 1992 |
Characterization of opioid receptors mediating stimulation of adenylate cyclase activity in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; Male; Narcotic Antagonists; Olfactory Bulb; Oligopeptides; Opioid Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1992 |
[Heterogeneity of mu- and delta-opioid active sites in the mouse cerebral cortex. Selective increase in the affinity of a superhigh affinity delta-site during long-term administration of morphine].
Topics: Animals; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Mice; Mice, Inbred C57BL; Morphine; Receptors, Opioid, delta; Receptors, Opioid, mu; Substrate Specificity | 1992 |
Lesioning of the nucleus basalis of Meynert has differential effects on mu, delta and kappa opioid receptor binding in rat brain: a quantitative autoradiographic study.
Topics: Animals; Autoradiography; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Male; Organ Specificity; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Substantia Innominata; Tritium | 1992 |
Opioid-inhibited adenylyl cyclase in rat brain membranes: lack of correlation with high-affinity opioid receptor binding sites.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding Sites; Brain; Cell Membrane; Colforsin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine Triphosphate; Male; Naloxone; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sodium; Sodium Chloride; Sodium Fluoride | 1992 |
Conformationally restricted deltorphin analogues.
Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Molecular Sequence Data; Oligopeptides; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cell Membrane; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guinea Pigs; Humans; Kinetics; Ligands; Placenta; Pregnancy; Prosencephalon; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid | 1992 |
Effects of stress on opioid receptor binding in the rat central nervous system.
Topics: Amino Acid Sequence; Analgesics; Animals; Central Nervous System; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Stress, Psychological; Water Deprivation | 1992 |
The effect of morphine tolerance-dependence and abstinence on mu, delta, and kappa opiate receptors of discrete brain regions and spinal cord of the rat.
Topics: Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 1990 |
Localisation and pharmacological characterisation of [3H]bremazocine binding in the bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Cattle; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1991 |
Modulation of mu, kappa and delta opioid receptors in the rat brain by isoflurane and enflurane.
Topics: Analgesics; Animals; Brain Chemistry; Cerebral Cortex; Enflurane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Isoflurane; Male; Mesencephalon; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Opioid inhibition of nicotine-induced 45Ca2(+)-uptake into cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Benzomorphans; Calcium; Cattle; Cells, Cultured; Chromaffin System; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Nicotine; Oligopeptides | 1991 |
Gender effects and central opioid analgesia.
Topics: Analgesics, Opioid; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Intraventricular; Male; Morphine; Narcotics; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seminal Vesicles; Sensory Thresholds; Sex Characteristics; Uterus | 1991 |
Modulation of a peripheral inflammatory response to substance P by locally administered opioid receptor agonists.
Topics: Administration, Topical; Amino Acid Sequence; Animals; Blister; Capillary Permeability; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Inflammation; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Perfusion; Peripheral Nerves; Rats; Skin; Substance P; Vasodilation | 1990 |
Nor-binaltorphimine decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Food Deprivation; Male; Naltrexone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Reference Values | 1990 |
Activation of mu- and delta-opioid receptors present on the same nerve terminals depresses transmitter release in the mouse hypogastric ganglion.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Ganglia; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Nerve Endings; Neurotransmitter Agents; Oligopeptides; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Modulation of mu, delta and kappa opioid receptors in rat brain by metal ions and histidine.
Topics: Animals; Brain Chemistry; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Histidine; Kinetics; Male; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfhydryl Reagents; Trace Elements; Zinc | 1990 |
Role of peripheral mu, delta and kappa opioid receptors in opioid-induced inhibition of gastrointestinal transit in rats.
Topics: Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; Male; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
[Kinetic characteristics of the effect of GTP on properties of opioid receptors].
Topics: Adenine Nucleotides; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; Kinetics; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Differential effects of cyanogen bromide on ligand binding by mu, delta and kappa opioid receptors.
Topics: Animals; Brain; Cell Membrane; Cyanogen Bromide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ligands; Male; Methionine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Effects of streptozotocin-induced diabetes on feeding stimulated by centrally administered opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Guanine nucleotide regulation of [125I]beta-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements.
Topics: beta-Endorphin; Cations; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Hybrid Cells; Neuroblastoma; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride; Tumor Cells, Cultured | 1989 |
Changes in multiple opioid receptors in regions of the brain in rats treated chronically with thyroxine.
Topics: Animals; Blood Pressure; Body Weight; Brain; Chromatography, High Pressure Liquid; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Heart Rate; Hyperthyroidism; Male; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Thyroxine | 1989 |
Different mu receptor subtypes mediate spinal and supraspinal analgesia in mice.
Topics: Analgesia; Anesthesia, Spinal; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Dermorphin gene sequence peptide with high affinity and selectivity for delta-opioid receptors.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Oligopeptides; Opioid Peptides; Protein Conformation; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes | 1989 |
Selective effects of ethanol on opiate receptor subtypes in brain.
Topics: Animals; Benzomorphans; Binding, Competitive; Brain Chemistry; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; In Vitro Techniques; Limbic System; Male; Mice; Mice, Inbred C57BL; Narcotics; Oligopeptides; Receptors, Opioid | 1987 |
Opioid receptors inhibit the adenylate cyclase in guinea pig cochleas.
Topics: Adenylyl Cyclases; Animals; Cochlea; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Naloxone; Oligopeptides; Receptors, Opioid | 1987 |
Autoradiographic distribution of multiple classes of opioid receptor binding sites in human forebrain.
Topics: Aged; Autoradiography; Benzomorphans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Humans; Male; Middle Aged; Oligopeptides; Receptors, Opioid; Tissue Distribution | 1987 |
Molecular mechanisms of ligand binding to opioid receptors: selective inhibition by ethanol?
Topics: Animals; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethanol; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spectrophotometry, Infrared | 1986 |
The direct demonstration of binding of mu, delta and kappa agonists to digitonin-solubilized opioid receptors from bovine striatum.
Topics: Analgesics; Animals; Benzomorphans; Cattle; Cell Membrane; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Morphinans; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanine Nucleotides; Guinea Pigs; Kinetics; Male; Naloxone; Oligopeptides; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1988 |
Effect of ethanol on the binding of conformationally rigid and labile ligands of opioid receptors to rat brain membranes.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; In Vitro Techniques; Male; Naltrexone; Oligopeptides; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Effect of methimazole-induced hypothyroidism on multiple opioid receptors in rat brain regions.
Topics: Animals; Body Temperature; Body Weight; Brain Chemistry; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Heart Rate; Hypothyroidism; Male; Methimazole; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Triiodothyronine | 1988 |
The stimulation of food intake by selective agonists of mu, kappa and delta opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Dynorphins; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1986 |
Effects of beta-chlornaltrexamine on food intake, body weight and opioid-induced feeding.
Topics: Animals; Body Weight; Dynorphins; Eating; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Opiate binding in calf thalamic membranes: a selective mu 1 binding assay.
Topics: Animals; Cattle; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus | 1988 |
Regulation of human natural cytotoxicity by enkephalins and selective opiate agonists.
Topics: Adult; Cell Division; Cytotoxicity, Immunologic; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Humans; Killer Cells, Natural; Lymphocytes; Naloxone; Oligopeptides; Receptors, Opioid; T-Lymphocytes | 1988 |
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: I. Interaction with delta and mu sites.
Topics: Adrenal Medulla; Animals; Binding Sites; Cattle; Cesium; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylmaleimide; Kinetics; Lithium; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium; Stereoisomerism | 1985 |
Sulfonic acid enkephalin: binding specificity to rat brain opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers.
Topics: Amino Acid Sequence; Animals; Biological Assay; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Macromolecular Substances; Male; Mice; Muscle Contraction; Oligopeptides; Peptides, Cyclic; Protein Conformation; Rats; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1985 |
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Guinea Pigs; Male; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1986 |
Interaction of [D-Ser2,Leu5]enkephalin-Thr6 (DSLET), a relatively selective delta ligand, with mu1 opioid binding sites.
Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Male; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Pharmacological and anatomical evidence of selective mu, delta, and kappa opioid receptor binding in rat brain.
Topics: Animals; Autoradiography; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse.
Topics: Analgesia; Anesthesia, Spinal; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
DSLET (D-ser2-leu5-enkephalin-Thr6) produces analgesia on the hot plate by mechanisms largely different from DAGO and morphine-like opioids.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Mice; Mice, Inbred Strains; Oligopeptides; Species Specificity; Structure-Activity Relationship | 1987 |
Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons.
Topics: Amino Acid Sequence; Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; GTP-Binding Proteins; In Vitro Techniques; Molecular Sequence Data; Naloxone; Nerve Endings; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Reticular Formation; Substance P | 1993 |
Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes.
Topics: Aging; Analgesics; Animals; Carbazoles; Cell Membrane; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guinea Pigs; Indoles; Kinetics; Male; Naltrexone; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Species Specificity | 1994 |
VV-hemorphin-7 and LVV-hemorphin-7 released during in vitro peptic hemoglobin hydrolysis are morphinomimetic peptides.
Topics: Animals; Binding, Competitive; Cattle; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Hemoglobins; Hydrolysis; Ileum; Male; Morphine; Naloxone; Pepsin A; Peptide Fragments; Rats; Rats, Wistar; Receptors, Opioid; Sensitivity and Specificity | 1995 |
Opioids modify the release of LH at the pituitary level: in vitro studies with entire rat pituitaries.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Naloxone; Narcotics; Oligopeptides; Organ Culture Techniques; Pituitary Gland; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella | 1993 |
Acute tolerance to the excitatory effects of opioids in the rat hippocampus.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; Male; Narcotics; Pyramidal Cells; Rats; Rats, Wistar | 1995 |
[Participation of central opiate receptors in the pathogenesis of adrenal arrhythmias].
Topics: Adrenal Gland Diseases; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Wistar; Receptors, Opioid | 1994 |
Opiate withdrawal intensity correlates with the presence of DSLET high-affinity binding.
Topics: Amino Acid Sequence; Analgesics; Animals; Drug Implants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Morphine; Morphine Dependence; Naloxone; Narcotics; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1994 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
[3H]dynorphin1-8 binding sites in frog (Rana esculenta) brain membranes.
Topics: Amino Acid Sequence; Animals; Brain; Cell Membrane; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Naloxone; Peptide Fragments; Rana esculenta; Receptors, Opioid; Sodium Chloride; Tritium | 1994 |
Opioid receptor density changes in Alzheimer amygdala and putamen.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Analgesics; Autoradiography; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Frontal Lobe; Humans; Kinetics; Male; Putamen; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Tritium | 1993 |
Purification to homogeneity of an active opioid receptor from rat brain by affinity chromatography.
Topics: Analgesics; Animals; Antibodies; Binding, Competitive; Blotting, Western; Brain; Cell Membrane; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Male; Molecular Weight; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Ultrafiltration | 1994 |
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.
Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Alterations in delta opioid receptor levels in discrete areas of the neocortex and in the globus pallidus of the aging guinea pig: a quantitative autoradiographic study.
Topics: Aging; Analgesics; Animals; Autoradiography; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Globus Pallidus; Guinea Pigs; In Vitro Techniques; Male; Radioligand Assay; Receptors, Opioid, delta | 1993 |
Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors.
Topics: Amino Acid Sequence; Analgesics; Base Sequence; Benzomorphans; Binding, Competitive; Cell Line; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Kidney; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Substrate Specificity; Transfection | 1995 |
Studies on inhibition of mu and delta opioid receptor binding by dithiothreitol and N-ethylmaleimide. His223 is critical for mu opioid receptor binding and inactivation by N-ethylmaleimide.
Topics: Amino Acid Sequence; Analgesics; Base Sequence; Binding Sites; Cell Line; Cell Membrane; Dithiothreitol; DNA Primers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylmaleimide; Histidine; Humans; Kidney; Kinetics; Ligands; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Serine; Transfection | 1996 |
[Mediated participation of the opioid system in regulation of pain sensitivity by peptide fragments MP1 and MP2].
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Molecular Sequence Data; Oligopeptides; Pain Threshold; Peptides; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Opioid regulation of intracellular free calcium in cultured mouse dorsal root ganglion neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Cells, Cultured; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ganglia, Spinal; Kinetics; Mice; Mice, Inbred C57BL; Neurons; Potassium Chloride; Pyrrolidines; Substance P | 1996 |
Supraspinal delta 2 opioid agonist analgesia in Swiss-Webster mice involves spinal GABAA receptors.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; GABA Antagonists; GABA-A Receptor Antagonists; Heroin; Injections, Intraventricular; Injections, Spinal; Mice; Molecular Sequence Data; Morphine Derivatives; Pain Measurement; Receptors, GABA-A; Receptors, Opioid, delta; Spinal Cord | 1996 |
The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors.
Topics: Adenocarcinoma; Amino Acid Sequence; Binding Sites; Breast Neoplasms; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Opioid Peptides; Receptors, Opioid; Tumor Cells, Cultured | 1996 |
The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene.
Topics: Allylamine; Analgesics, Opioid; Animals; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Isonipecotic Acids; Meperidine; Parasympatholytics; Phenols; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Reversible affinity labeling of opioid receptors via disulfide bonding: discriminative labeling of mu and delta subtypes by chemically activated thiol-containing enkephalin analogs.
Topics: Affinity Labels; Animals; Binding Sites; Brain; Disulfides; Dithiothreitol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylmaleimide; In Vitro Techniques; Kinetics; Molecular Structure; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfhydryl Reagents | 1996 |
Laminar distribution of the multiple opioid receptors in the human cerebral cortex.
Topics: Aged; Aged, 80 and over; Analgesics; Autoradiography; Benzomorphans; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Humans; Male; Organ Specificity; Postmortem Changes; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1996 |
The effect of pretreatment with a delta 2-opioid receptor antisense oligodeoxynucleotide on the recovery from acute antinociceptive tolerance to delta 2-opioid receptor agonist in the mouse spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Oligopeptides; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; RNA, Antisense | 1997 |
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors | 1997 |
Opioids in the nucleus of the solitary tract are involved in feeding in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Male; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
Efficacy and kinetics of opioid action on acutely dissociated neurons.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines | 1997 |
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon | 1997 |
[Effect of opioid peptides on immunomodulation].
Topics: Animals; Cyproheptadine; Dopamine D2 Receptor Antagonists; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Haloperidol; Male; Mice; Mice, Inbred CBA; Neuroimmunomodulation; Pituitary Gland; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Serotonin; Spleen | 1998 |
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists.
Topics: Analgesics; Analgesics, Opioid; Binding, Competitive; Biological Transport; Carcinogens; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Humans; Kinetics; Membrane Proteins; Morphine; Naloxone; Narcotic Antagonists; Neuroblastoma; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Opioid, mu; Second Messenger Systems; Time Factors; Tritium; Tumor Cells, Cultured | 1999 |
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC.
Topics: Analgesics; Analgesics, Opioid; Biological Transport; Carcinogens; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Humans; Immunoblotting; Isoenzymes; Narcotic Antagonists; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Receptors, Opioid, mu; Second Messenger Systems; Tritium; Tumor Cells, Cultured | 1999 |
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus | 1999 |
Binding properties of C-truncated delta opioid receptors.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Peptide Fragments; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
[Effects of opioid peptides on ischemic myocardial arrhythmias during laser irradiation and disturbed heart sympathetic innervation].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Heart; Lasers; Male; Myocardial Ischemia; Myocardium; Opioid Peptides; Receptors, Opioid; Sympathectomy | 1999 |
Opioid agonist modulation of cytoplasmic free Ca2+ level in concanavalin A-stimulated mouse lymphocytes.
Topics: Animals; Calcium; Concanavalin A; Cytoplasm; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred CBA; Peptide Fragments; Receptors, Opioid | 1999 |
Opioids modulate cell division in the germinal zone of the late embryonic neocortex.
Topics: Animals; Benzomorphans; Cell Division; Cerebral Ventricles; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Mice; Mice, Inbred CBA; Mitotic Index; Naloxone; Narcotic Antagonists; Narcotics; Neocortex; Pregnancy; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Affinity labeling of delta opioid receptors by an enkephalin-derivative alkylating agent, DSLET-Mal.
Topics: Affinity Labels; Alkylating Agents; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Kinetics; Male; Oligopeptides; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Blotting, Western; Bradykinin; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enzyme Inhibitors; Male; Mice; Morphine; Nociceptors; Oligonucleotides, Antisense; Pain Measurement; Peripheral Nervous System; Protein Kinase C; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists.
Topics: Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Motor Cortex; Myocardial Ischemia; Peptide Fragments; Receptors, Opioid | 2000 |
Stimulation of mu and delta-Opiate Receptors and Tolerance of Isolated Heart to Oxidative Stress: the Role of NO-Synthase.
Topics: Animals; Creatine Kinase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; In Vitro Techniques; Injections, Intravenous; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Perfusion; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Superoxide Dismutase | 2001 |
[The role of mu- and delta-opiate receptors in resistance of the myocardium to free radical damage].
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Free Radicals; In Vitro Techniques; Lipid Peroxidation; Myocardial Contraction; Myocardium; Oligopeptides; Oxidative Stress; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2001 |
Parallel nociceptive reflex pathways with negative and positive feedback functions to foot extensors in the cat.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Cats; Dopamine Agents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feedback, Physiological; Foot; Levodopa; Locomotion; Mechanoreceptors; Monoamine Oxidase Inhibitors; Muscle, Skeletal; Neural Inhibition; Nialamide; Nociceptors; Physical Stimulation; Reflex; Spinal Cord; Tibial Nerve | 2001 |
The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells.
Topics: Benzeneacetamides; Cell Division; Cell Survival; Colorimetry; DNA Fragmentation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Humans; Leukemia; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2002 |
[Effect of opioid peptides on proliferation and differentiation of skeletogenic cells of rabbit bone marrow in vitro].
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Fibroblasts; Hematopoietic Stem Cells; Opioid Peptides; Osteogenesis; Rabbits; Radius; Stromal Cells | 2002 |
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin | 2005 |
Differentiation between Aδ and C fibre evoked nociceptive reflexes by TTX resistance and opioid sensitivity in the cat.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Excitatory Postsynaptic Potentials; Female; Foot; Male; Naloxone; Narcotic Antagonists; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Reflex; Spinal Cord; Tetrodotoxin | 2011 |
Effect of opioid peptides on the content of LPO products and antioxidant enzyme activity in the liver of rats after restraint stress.
Topics: Analgesics, Opioid; Animals; Catalase; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Stress, Physiological; Superoxide Dismutase | 2012 |
[THE INFLUENCE OF OPIOID PEPTIDES ON LIPID PEROXIDATION AND ANTIOXIDANT ENZYME ACTIVITY IN RATS AFTER SWIMMING STRESS].
Topics: Analgesics, Opioid; Animals; Catalase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Stress, Psychological; Superoxide Dismutase; Swimming | 2015 |
Effects of Opioid Peptides on Changes in Lipid Metabolism in Rats Subjected to Swimming Stress.
Topics: Analgesics, Opioid; Animals; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Fatty Acids, Nonesterified; Lipid Metabolism; Male; Peptide Fragments; Rats; Rats, Wistar; Stress, Psychological; Swimming; Triglycerides | 2017 |
[THE INFLUENCE OF OPIOID PEPTIDES DSLET AND DAGO ON LIPID PEROXIDATION AND THE ACTIVITY OF ANTIOXIDANT ENZYMES IN THE LIVER TISSUE OF RATS IN THE STRESS OF DIFFERENT DURATION].
Topics: Animals; Antioxidants; Catalase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Immobilization; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Stress, Psychological; Superoxide Dismutase | 2016 |