enkephalin, leucine and ubenimex

enkephalin, leucine has been researched along with ubenimex in 61 studies

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-199040 (65.57)18.7374
1990's17 (27.87)18.2507
2000's1 (1.64)29.6817
2010's2 (3.28)24.3611
2020's1 (1.64)2.80

Authors

AuthorsStudies
Bawab, W; Crine, P; DesGroseillers, L; Querido, E1
Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S1
Baas, AA; Dzoljic, MM; Dzoljic, MR; Rupreht, J; Ukponmwan, OE; van den Berg, DJ1
Ishikawa, K; Martinez, JL; Shibanoki, S; Weinberger, SB1
Ayala, JM; Molineaux, CJ1
Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC1
Beniston, D; Bennett, EL; Ishikawa, K; Martinez, JL; Nudelman, KA; Rosenzweig, MR; Schulteis, G; Shibanoki, S; Weinberger, SB1
Beliaev, NA; Kelesheva, LF; Kolesanova, EF; Panchenko, LF; Rotanova, TV1
Giros, B; Llorens-Cortes, C; Quach, TT; Schwartz, JC; Van Amsterdam, JG1
Herz, A; Parsons, CG1
Aungst, BJ; Hussain, MA; Koval, CA; Shenvi, AB1
Caline, H; Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC1
Livett, BG; Marley, PD; Mitchelhill, KI1
Martinez, JL; Weinberger, SB1
Altiere, RJ; Crooks, PA; Gillespie, MN; Krechniak, JW; Olson, JW1
Giros, B; Gros, C; Llorens-Cortes, C; Schwartz, JC1
Barchas, JD; Evans, CJ; Hurlbut, DE; Leslie, FM1
Bausback, HH; Churchill, L; Palmieri, FE; Ward, PE1
Martinez, JL; Walker, RC; Weinberger, SB; Zafuto, CE1
Gros, C; Llorens-Cortes, C; Schwartz, JC2
Hammonds, RG; Li, CH; Westphal, M1
Kameyama, T; Katoh, A; Nabeshima, T1
Dzoljić, E; Varagić, VM1
Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF1
Carson, LW; Kashi, SD; Lee, VH; Stratford, RE1
Audus, KL; Baranczyk-Kuzma, A1
Bouboutou, R; Bourgoin, S; Cesselin, F; Devin, J; Fournie-Zaluski, MC; Hamon, M; Roques, B; Waksman, G1
Han, JS; Yuan, H1
Han, JS; Jin, WQ; Zhou, ZF1
Bailey, C; Kitchen, I1
Iwama, T; Satoh, M; Takagi, H; Wada, T1
Chaillet, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Zajac, JM1
Aoki, K; Kajiwara, M; Oka, T1
Bui, ND; Deschodt-Lanckman, M1
Corbett, AD; Kosterlitz, HW; McKnight, AT1
Chaillet, P; Costentin, J; de la Baume, S; Marcais-Collado, H; Schwartz, JC; Yi, CC3
Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP1
Brandt, U; Lentzen, H; Palenker, J1
Lentzen, H; Palenker, J1
Geary, LE; Kerchner, GA1
Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A1
Bouboutou, R; Chaillet, P; Cherot, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Waksman, G1
Chaillet, P; Costentin, J; Lecomte, JM; Marçais, H; Natan, LB; Uchida, G1
Llorens-Cortes, C; Schwartz, JC1
Costa, E; Yang, HY; Zhang, AZ1
Cohen, ML; Geary, LE; Wiley, KS1
Hazato, T; Kasama, A; Katayama, T; Kaya, K; Nishioka, S; Shimamura, M1
Hazato, T; Inagaki-Shimamura, M; Katayama, T; Yamamoto, T1
Baronets, VIu; Beliaev, NA; Kolesanova, EF; Panchenko, LF1
Billington, D; MacKinnon, KL; Zuzel, KA1
Grupp, LA; Harding, S; Szczepanska, R1
Ekström, G; Krondahl, E; Lennernäs, H; Orzechowski, A1
Anderson, L; Bussler, B; Dufton, M; Martins, H1
Abramić, M; Balog, T; Hrsak, I; Marotti, T; Svoboda-Beusen, I1
Albiston, AL; Ascher, DB; Chai, SY; Lew, RA; Morton, CJ; Parker, MW; Ye, S1
Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C1
Katsuyama, S; Komatsu, T; Mizoguchi, H; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M1
Bagley, EE; Gregoriou, GC; Patel, SD; Winters, BL1

Other Studies

61 other study(ies) available for enkephalin, leucine and ubenimex

ArticleYear
Identification and characterization of aminopeptidases from Aplysia californica.
    The Biochemical journal, 1992, Sep-15, Volume: 286 ( Pt 3)

    Topics: Aminopeptidases; Anilides; Aniline Compounds; Animals; Anti-Bacterial Agents; Aplysia; Bacitracin; Chromatography, High Pressure Liquid; Enkephalin, Leucine; FMRFamide; Ganglia; Hemolymph; Kidney; Leucine; Male; Myocardium; Neuropeptides; Oligopeptides; Oviducts; Peptides; Puromycin; Testis

1992
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
    Synapse (New York, N.Y.), 1992, Volume: 11, Issue:1

    Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan

1992
Suppressive effects of enkephalins and REM sleep deprivation on seizures.
    Epilepsy research. Supplement, 1991, Volume: 2

    Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Enkephalins; Glycopeptides; Leucine; Male; Mice; Mice, Inbred Strains; Neprilysin; Nitrous Oxide; Rats; Rats, Inbred Strains; Sleep Deprivation; Sleep, REM; Substance Withdrawal Syndrome; Thiorphan

1991
HPLC-ECD determination of the enzymatic hydrolysis of [leu]- and [met]enkephalin in rat plasma.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Acetylcholinesterase; Aminopeptidases; Animals; Captopril; CD13 Antigens; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Leucine; Male; Oligopeptides; Rats; Rats, Inbred Strains; Thiorphan; Tyrosine

1990
An inhibitor of endopeptidase-24.15 blocks the degradation of intraventricularly administered dynorphins.
    Journal of neurochemistry, 1990, Volume: 55, Issue:2

    Topics: Animals; Brain; Captopril; Cerebral Ventricles; Choroid Plexus; Dynorphins; Enkephalin, Leucine; Kinetics; Leucine; Male; Metalloendopeptidases; Neprilysin; Oligopeptides; Peptide Fragments; Peptidyl-Dipeptidase A; Perfusion; Rats; Rats, Inbred Strains

1990
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
    Neuropeptides, 1990, Volume: 15, Issue:2

    Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan

1990
Hydrolysis of [Leu]enkephalin by chick plasma in vitro.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:2

    Topics: Aminopeptidases; Animals; Chickens; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enkephalin, Leucine; Hydrolysis; In Vitro Techniques; Leucine; Male; Puromycin

1991
[The effect of the aminopeptidase inhibitor bestatin on the enkephalin level in the rat brain].
    Biulleten' eksperimental'noi biologii i meditsiny, 1990, Volume: 110, Issue:11

    Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Dimethyl Sulfoxide; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Leucine; Male; Rats

1990
Enkephalin biosynthesis and release in mouse striatum are inhibited by GABA receptor stimulation: compared changes in preproenkephalin mRNA and Tyr-Gly-Gly levels.
    Brain research. Molecular brain research, 1990, Volume: 8, Issue:3

    Topics: Aminooxyacetic Acid; Animals; Corpus Striatum; Diazepam; Enkephalins; Flumazenil; Kinetics; Leucine; Male; Mice; Muscimol; Oligopeptides; Protein Precursors; Receptors, GABA-A; RNA, Messenger

1990
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming; Thiorphan

1990
Recovery of rat nasal mucosa from the effects of aminopeptidase inhibitors.
    Journal of pharmaceutical sciences, 1990, Volume: 79, Issue:5

    Topics: Aminopeptidases; Animals; Boron; Boron Compounds; Enkephalin, Leucine; Leucine; Nasal Mucosa; Puromycin; Rats

1990
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
    Neuropharmacology, 1989, Volume: 28, Issue:2

    Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Pain; Protease Inhibitors; Reference Values; Species Specificity; Thiorphan

1989
Effects of opioid peptides containing the sequence of Met5-enkephalin or Leu5-enkephalin on nicotine-induced secretion from bovine adrenal chromaffin cells.
    Journal of neurochemistry, 1986, Volume: 46, Issue:1

    Topics: Adenosine Triphosphate; Adrenal Medulla; Amino Acid Sequence; Animals; Bacitracin; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guinea Pigs; Leucine; Nicotine; Norepinephrine; Peptide Fragments; Phenanthrolines; Rabbits; Receptors, Opioid; Thiorphan; Tiopronin

1986
Characterization of hydrolysis of [leu]enkephalin and D-ala2-[L-leu]enkephalin in rat plasma.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1

    Topics: Aminopeptidases; Animals; CD13 Antigens; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Half-Life; Hydrolysis; Leucine; Male; Neprilysin; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Strains; Thiorphan

1988
Pulmonary metabolism of exogenous enkephalins in isolated perfused rat lungs.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3

    Topics: Aminopeptidases; Animals; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Leucine; Lung; Male; Oligopeptides; Peptidyl-Dipeptidase A; Perfusion; Rats; Rats, Inbred Strains; Tyrosine

1985
[Opioid peptides: metabolism and receptors].
    Gastroenterologie clinique et biologique, 1987, Volume: 11, Issue:3 Pt 2

    Topics: Animals; Brain; Cattle; Endopeptidases; Endorphins; Enkephalins; Humans; Leucine; Mice; Neprilysin; Pro-Opiomelanocortin; Protease Inhibitors; Protein Precursors; Receptors, Opioid; Thiorphan; Tiopronin

1987
Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18.
    European journal of pharmacology, 1987, Jun-26, Volume: 138, Issue:3

    Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Naloxone; Protein Precursors; Radioligand Assay; Receptors, Opioid; Structure-Activity Relationship

1987
Kinin and enkephalin conversion by an endothelial, plasma membrane carboxypeptidase.
    Biochemical pharmacology, 1986, Aug-15, Volume: 35, Issue:16

    Topics: 3-Mercaptopropionic Acid; Animals; Carboxypeptidases; Cell Membrane; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Edetic Acid; Endothelium; Enkephalins; Glycopeptides; Hydrogen-Ion Concentration; Kinetics; Kinins; Leucine; Lysine Carboxypeptidase; Microscopy, Phase-Contrast; Muscle, Smooth, Vascular; Phenanthrolines; Puromycin; Swine

1986
Characterization of enkephalin degradation in rat plasma.
    NIDA research monograph, 1986, Volume: 75

    Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Leucine; Enkephalins; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin

1986
Evaluation of striatal enkephalin release in vivo from steady state levels and turnover rates of the tripeptide Tyr-Gly-Gly.
    NIDA research monograph, 1986, Volume: 75

    Topics: Animals; Anti-Bacterial Agents; Corpus Striatum; Enkephalins; In Vitro Techniques; Kinetics; Leucine; Male; Mice; Oligopeptides; Pentobarbital; Thiorphan; Tiopronin

1986
Protease inhibition increases the analgesic potency of peptide E.
    Neuropharmacology, 1985, Volume: 24, Issue:2

    Topics: Analgesics; Animals; Bacitracin; beta-Endorphin; Drug Synergism; Endorphins; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Peptides; Protease Inhibitors

1985
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility).
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1

    Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin

1988
Effects of bestatin and phosphoramidon on the hypertensive response to physostigmine in the rat.
    Fundamental & clinical pharmacology, 1987, Volume: 1, Issue:5

    Topics: Animals; Antibiotics, Antineoplastic; Blood Pressure; Carotid Arteries; Catecholamines; Enkephalin, Leucine; Female; Glycopeptides; Injections, Intra-Arterial; Leucine; Male; Naloxone; Physostigmine; Rats; Rats, Inbred Strains

1987
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
    Brain research, 1987, Apr-07, Volume: 408, Issue:1-2

    Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin

1987
Metabolic and permeation barriers to the ocular absorption of topically applied enkephalins in albino rabbits.
    Journal of ocular pharmacology, 1986,Fall, Volume: 2, Issue:4

    Topics: Absorption; Administration, Topical; Animals; Enkephalins; Eye; Leucine; Male; Permeability; Rabbits

1986
Characteristics of aminopeptidase activity from bovine brain microvessel endothelium.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1987, Volume: 7, Issue:6

    Topics: Aminopeptidases; Animals; Blood-Brain Barrier; Brain; Cattle; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Enkephalins; Kidney; Leucine; Neuropeptides; Puromycin

1987
In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain.
    European journal of pharmacology, 1985, Nov-05, Volume: 117, Issue:2

    Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Corpus Striatum; Dipeptides; Enkephalin, Methionine; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Mice; Protease Inhibitors; Rats; Thiorphan; Tiopronin

1985
[Electroacupuncture accelerates the biogenesis of central enkephalins in the rat].
    Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:3

    Topics: Acupuncture Therapy; Aminopeptidases; Animals; Brain; Electric Stimulation Therapy; Enkephalin, Leucine; Enkephalin, Methionine; Female; Leucine; Male; Phenylalanine; Radioimmunoassay; Rats; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation

1985
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors.
    European journal of pharmacology, 1985, Dec-17, Volume: 119, Issue:3

    Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Mice; Microwaves; Nalorphine; Neprilysin; Oligopeptides; Protease Inhibitors; Radioimmunoassay; Thiorphan; Tiopronin

1985
[Inhibition of enkephalins degradation in the nucleus accumbens leads to potentiation of acupuncture and morphine analgesia].
    Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:4

    Topics: Acupuncture Therapy; Aminopeptidases; Analgesia; Animals; Electric Stimulation Therapy; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Morphine; Neprilysin; Nucleus Accumbens; Protease Inhibitors; Rabbits; Septal Nuclei; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation

1985
Determination of proenkephalin products in brain tissue by high-performance liquid chromatography and a modified bioassay procedure.
    Journal of pharmacological methods, 1985, Volume: 13, Issue:3

    Topics: Animals; Biological Assay; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Leucine; Male; Mice; Muscle Contraction; Muscle, Smooth; Protein Precursors

1985
Sites of analgesic actions of kyotorphin and D-kyotorphin in the central nervous system of rats.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Analgesics; Animals; Central Nervous System; Endorphins; Enkephalins; Leucine; Male; Naloxone; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord

1985
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia.
    European journal of pharmacology, 1984, May-18, Volume: 101, Issue:1-2

    Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan; Tiopronin

1984
The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum.
    Japanese journal of pharmacology, 1984, Volume: 36, Issue:1

    Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Neprilysin; Oligopeptides; Peptides; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin

1984
Cholecystokinin octa- and tetrapeptide degradation by synaptic membranes. I. Evidence for competition with enkephalins for in vitro common degradation pathways.
    Peptides, 1981, Volume: 2 Suppl 2

    Topics: Aminopeptidases; Animals; Cholecystokinin; Chromatography, DEAE-Cellulose; Endorphins; Enkephalin, Leucine; Enkephalins; Gastrins; Kinetics; Leucine; Male; Peptide Fragments; Rats; Sincalide; Synaptic Membranes; Tetragastrin; Tryptophan

1981
Increase in potencies of opioid peptides after peptidase inhibition.
    European journal of pharmacology, 1983, Jan-21, Volume: 86, Issue:3-4

    Topics: Animals; beta-Endorphin; Captopril; Dipeptides; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Leucine; Male; Mice; Myenteric Plexus; Protease Inhibitors; Rats; Rats, Inbred Strains; Vas Deferens

1983
Participation of both 'enkephalinase' and aminopeptidase activities in the metabolism of endogenous enkephalins.
    Neuroscience, 1983, Volume: 8, Issue:1

    Topics: Aminopeptidases; Animals; Corpus Striatum; Endopeptidases; Enkephalins; Leucine; Male; Neprilysin; Nociceptors; Rats; Rats, Inbred Strains; Sensory Thresholds; Synaptic Transmission

1983
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin

1983
Enkephalin degradation by enkephalinergic neuroblastoma cells. Involvement of angiotensin-converting-enzyme.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 325, Issue:3

    Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Cell Membrane; Cells, Cultured; Enkephalin, Leucine; Hydrolysis; Leucine; Mice; Neuroblastoma; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin

1984
Localization of the thiorphan-sensitive endopeptidase, termed enkephalinase A, on glial cells.
    FEBS letters, 1983, Mar-07, Volume: 153, Issue:1

    Topics: Aminopeptidases; Animals; Astrocytes; Brain; Cell Membrane; Cells, Cultured; Endopeptidases; Enkephalin, Leucine; Kinetics; Leucine; Neprilysin; Protease Inhibitors; Rats; Thiorphan; Tiopronin

1983
Studies on the transport of enkephalin-like oligopeptides in rat intestinal mucosa.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:1

    Topics: Aminopeptidases; Animals; Biological Transport, Active; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Intestinal Mucosa; Jejunum; Kinetics; Leucine; Male; Oligopeptides; Puromycin; Rats; Rats, Inbred Strains; Tyrosine

1983
Peptidases involved in the inactivation of exogenous and endogenous enkephalins.
    Journal of neural transmission. Supplementum, 1983, Volume: 18

    Topics: Aminopeptidases; Animals; Brain; Endopeptidases; Enkephalins; Leucine; Mice; Neprilysin; Nociceptors; Rats; Thiorphan; Tiopronin

1983
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats.
    Neuropharmacology, 1983, Volume: 22, Issue:11

    Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Species Specificity; Thiorphan; Tiopronin

1983
Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes.
    European journal of pharmacology, 1984, Jul-20, Volume: 102, Issue:3-4

    Topics: Aminopeptidases; Analgesics; Animals; Brain; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kidney; Leucine; Neprilysin; Protease Inhibitors; Rabbits; Rats; Reaction Time; Thiorphan; Tiopronin

1984
Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor.
    European journal of pharmacology, 1983, Jan-21, Volume: 86, Issue:3-4

    Topics: Aminopeptidases; Analgesics; Animals; Brain; Drug Synergism; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Puromycin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin

1983
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test.
    European journal of pharmacology, 1984, Jan-27, Volume: 97, Issue:3-4

    Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin

1984
Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin.
    European journal of pharmacology, 1984, Sep-17, Volume: 104, Issue:3-4

    Topics: alpha-Methyltyrosine; Amino Acids, Sulfur; Aminopeptidases; Animals; Biogenic Amines; Brain; Enkephalins; Leucine; Male; Methyltyrosines; Mice; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin

1984
Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors.
    Neuropharmacology, 1982, Volume: 21, Issue:7

    Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Enkephalins; Exopeptidases; Female; Leucine; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin

1982
Enkephalin degradation in the guinea-pig ileum: effect of aminopeptidase inhibitors, puromycin and bestatin.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:2

    Topics: Aminopeptidases; Animals; Enkephalins; Guinea Pigs; Ileum; Leucine; Male; Puromycin

1983
Enkephalin degrading enzymes in cerebrospinal fluid.
    Life sciences, 1983, Aug-01, Volume: 33, Issue:5

    Topics: Cerebrospinal Fluid; Enkephalins; Humans; Kinetics; Leucine; Protease Inhibitors

1983
Separation and characterization of a dipeptidyl aminopeptidase that degrades enkephalins from monkey brain.
    Biochemical and biophysical research communications, 1982, Mar-30, Volume: 105, Issue:2

    Topics: Aminopeptidases; Animals; Brain; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Endorphins; Enkephalins; Leucine; Macaca fascicularis; Puromycin

1982
[Some features of enkephalin metabolism in the rat brain after administration of bestatin].
    Biokhimiia (Moscow, Russia), 1993, Volume: 58, Issue:7

    Topics: Aminopeptidases; Animals; Brain; Carboxypeptidase H; Carboxypeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Neprilysin; Rats

1993
Hepatic inactivation of Leu-enkephalin.
    Regulatory peptides, 1996, Dec-03, Volume: 67, Issue:2

    Topics: Animals; Biliary Tract; Biotransformation; CD13 Antigens; Cell Membrane; Enkephalin, Leucine; Hydrolysis; Iodine Radioisotopes; Leucine; Liver; Male; Mice; Perfusion; Protease Inhibitors; Rats; Rats, Wistar; Succinimides; Tritium; Tyrosine

1996
Characterization of the decline in alcohol consumption by aminopeptidase inhibition.
    Drug and alcohol dependence, 1996, Dec-11, Volume: 43, Issue:3

    Topics: Alcohol Drinking; Aminopeptidases; Angiotensin II; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drinking Behavior; Enkephalins; Imidazoles; Leucine; Losartan; Male; Naltrexone; Rats; Rats, Wistar; Tetrazoles

1996
Rat jejunal permeability and metabolism of mu-selective tetrapeptides in gastrointestinal fluids from humans and rats.
    Pharmaceutical research, 1997, Volume: 14, Issue:12

    Topics: Amidines; Animals; Drug Stability; Enkephalins; Gastric Juice; Humans; Intestinal Absorption; Jejunum; Leucine; Male; Microvilli; Oligopeptides; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Sulfones; Thiorphan

1997
Enkephalin-processing oligopeptidases in cobra venom: inhibition by thiorphan and bestatin reveals co-operative actions.
    Toxicon : official journal of the International Society on Toxinology, 1998, Volume: 36, Issue:5

    Topics: Aminopeptidases; Animals; Drug Synergism; Elapid Venoms; Elapidae; Enkephalins; In Vitro Techniques; Leucine; Peptide Hydrolases; Protease Inhibitors; Substrate Specificity; Thiorphan

1998
The role of aminopeptidase N in Met-enkephalin modulated superoxide anion release.
    Immunopharmacology, 1999, Volume: 41, Issue:1

    Topics: Adult; Analgesics; Analgesics, Opioid; CD13 Antigens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Leucine; Male; Neutrophils; Oligopeptides; Protease Inhibitors; Superoxides

1999
Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2008, Volume: 86, Issue:3

    Topics: Amino Acid Sequence; Catalytic Domain; Cell Line; Cystinyl Aminopeptidase; Enkephalin, Leucine; Humans; Kinetics; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Recombinant Proteins; Sequence Homology, Amino Acid; Vasopressins

2008
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:12

    Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan

2012
Spinal ERK2 activation through δ2-opioid receptors contributes to nociceptive behavior induced by intrathecal injection of leucine-enkephalin.
    Peptides, 2014, Volume: 54

    Topics: Animals; Arginine; Behavior, Animal; Butadienes; Enkephalin, Leucine; Enzyme Activation; Glycopeptides; Injections, Spinal; Leucine; Male; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Nociception; Protease Inhibitors; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Spinal Cord

2014
Neprilysin Controls the Synaptic Activity of Neuropeptides in the Intercalated Cells of the Amygdala.
    Molecular pharmacology, 2020, Volume: 98, Issue:4

    Topics: Amygdala; Animals; Captopril; Electrical Synapses; Enkephalins; Glutamic Acid; Leucine; Male; Neprilysin; Protease Inhibitors; Proteolysis; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiorphan

2020