enkephalin, leucine has been researched along with u 69593 in 108 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (6.48) | 18.7374 |
| 1990's | 93 (86.11) | 18.2507 |
| 2000's | 8 (7.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L | 1 |
| Borsodi, A; Búzás, B; Cavagnero, S; Hruby, VJ; Tóth, G | 1 |
| Barnard, EA; Richardson, A; Simon, J | 1 |
| Green, IC; Khawaja, XZ | 1 |
| Kuemmerle, JF; Makhlouf, GM | 1 |
| Barnard, EA; Demoliou-Mason, C; Richardson, A | 1 |
| Besse, D; Besson, JM; Lombard, MC; Perrot, S | 1 |
| Finberg, RW; Heagy, W; Shipp, MA | 1 |
| Besse, D; Besson, JM; Butler, SH; Lombard, MC; Weil-Fugazza, J | 1 |
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Herz, A; Shippenberg, TS; Spanagel, R | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Leslie, FM; Loughlin, SE; Smith, JA | 1 |
| Mosberg, HI; Porreca, F; Vanderah, T; Wild, KD | 1 |
| Christensen, CB; Reiff, L | 1 |
| Dissanayake, VU; Hughes, J; Hunter, JC | 1 |
| Elde, RP; Lacey, CB; Miller, KE; Seybold, VS; Stevens, CW | 1 |
| Bennett, GJ; Kajander, KC; Seybold, VS; Stevens, CW | 1 |
| Bhargava, HN; Gulati, A; Rahmani, NH | 1 |
| Hauser, KF; Stiene-Martin, A | 1 |
| Imanishi, Y; Kimura, S; Sasaki-Yagi, Y | 1 |
| Enger, M; Grynne, BH; Holmen, AT; Maurset, AR | 1 |
| Cheng, J; Pasternak, GW; Paul, D; Pick, CG | 1 |
| Kromer, W | 1 |
| Adler, MW; Eisenstein, TK; Geller, EB; Rogers, TJ; Taub, DD | 1 |
| Berzetei-Gurske, I; Loew, GH | 1 |
| Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN | 1 |
| Magnan, J; Tiberi, M | 2 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Bourne, RC; Csillag, A; Stewart, MG | 1 |
| Green, J; Harris, S; Lloyd, P; Lozito, R; Messineo, E; Ossipov, MH | 1 |
| Dashwood, MR; Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Bastagli, L; Bernardi, P; Caldarera, CM; Guarnieri, C; Ventura, C | 1 |
| La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 1 |
| Cicero, TJ; Nock, B; O'Connor, LH; Rajpara, A | 1 |
| De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A | 1 |
| Carter, BD; Clark, MJ; Medzihradsky, F | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Fukuda, K; Fukushima, N; Misu, Y; Miyamae, T; Sasaki, Y; Takeshima, H; Ueda, H | 1 |
| Archer, S; Bidlack, JM; Jiang, Q; Seyed-Mozaffari, A | 1 |
| Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Glick, SD; Herrick-Davis, K; Pearl, SM; Teitler, M | 1 |
| Almeida, OF; Shippenberg, TS; Spanagel, R | 1 |
| Mignat, C; Wille, U; Ziegler, A | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Iwai, T; Luay, AE; Niwa, M; Nozaki, M; Tsurumi, K | 1 |
| Barg, J; Belcheva, MM; Coscia, CJ; Dawn, S; Ho, MT; Ignatova, E; McHale, RJ | 1 |
| Hirokami, M; Matsumoto, M; Saito, H; Togashi, H; Yoshioka, M | 1 |
| Bernstein, RN; Bilsky, EJ; Hruby, VJ; Lai, J; Pasternak, GW; Patel, D; Porreca, F | 1 |
| Akil, H; Fox, CA; Mansour, A; Meng, F; Watson, SJ | 1 |
| Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H | 1 |
| Glaum, SR; Miller, RJ; Rhim, H | 1 |
| Barg, J; Belcheva, M; Burke, WJ; Chung, HD; Coscia, CJ; Ho, A; Rowinski, J; Schmidt, CA | 1 |
| Hirokami, M; Ikeda, T; Matsumoto, M; Saito, H; Smith, CB; Tochihara, M; Togashi, H; Yoshioka, M | 1 |
| Fukushima, N; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Mulder, AH; Ronken, E; Schoffelmeer, AN | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
| Beatty, MF; Casy, AF; Kamal, JJ; Loew, GH; Maguire, PA; Perez, JJ; Rodriguez, L; Tsai, NF; Upton, C; Villar, HO | 1 |
| Ishige, K; Ito, Y; Makimura, M; Murakoshi, Y | 1 |
| German, DC; Manaye, KF; Sadeq, M; Speciale, SG | 1 |
| Matsumoto, M; Saito, H; Smith, CB; Togashi, H; Yoshioka, M | 1 |
| Desmeules, JA; Guilbaud, G; Kayser, V | 1 |
| Davis, P; DeLeon, IA; Hruby, VJ; Li, G; Lou, BS; Lung, FD; Meyer, JP; Porreca, F; Xiang, L; Yamamura, HI | 1 |
| Avidor-Reiss, T; Levy, R; Nevo, I; Pfeuffer, T; Vogel, Z | 1 |
| Cox, BM; Stevens, BA; Tang, T | 1 |
| Chang, KJ; Li, LY | 1 |
| Jewett, DC; Mosberg, HI; Woods, JH | 1 |
| Allard, M; Jordan, D; Kopp, N; Martin, D; Ries, C; Simonnet, G; Tafani, JA; Zajac, JM | 1 |
| Demedts, MG; Dupont, LJ; Pype, JL; Verleden, GM | 1 |
| Obermeier, H; Schulz, R; Wehmeyer, A | 1 |
| Nelson, WL; Palmer, RB; Upthagrove, AL | 1 |
| Archer, S; Bidlack, JM; McLaughlin, JP; Sebastian, A | 1 |
| Berzetei-Gurske, IP; Chang, AC; Portoghese, PS; Schwartz, RW | 1 |
| Caudle, RM; Dubner, R; Ho, J; Mannes, AJ | 1 |
| Contarino, A; Drago, F; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A | 1 |
| Bandler, R; Christie, MJ; Crowfoot, LJ; Floyd, NS; Henderson, LA; Keay, KA | 1 |
| Eckhoff, B; Frenzen, G; Höfner, G; Klindert, T; Seitz, G; Stroetmann, I; Wanner, KT | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Gauthier, CA; Gonzales, GR; Minor, LD; Paul, D | 1 |
| Bhargava, HN; Cortijo, J; Morcillo, EJ; Villar, VM | 1 |
| Avidor-Reiss, T; Barg, J; Belcheva, MM; Coscia, CJ; Ignatova, E; Levy, R; Vogel, Z; Young, EC; Zippel, R | 1 |
| Bizot-Espiard, JG; Caignard, DH; Guillaumet, G; Pfeiffer, B; Renard, P; Savelon, L; Viaud, MC | 1 |
| Miller, RJ; Simen, AA | 1 |
| Aynsley-Green, A; Dashwood, MR; Dickenson, AH; Fitzgerald, M; Rahman, W | 1 |
| Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G | 1 |
| Lysle, DT; Schneider, GM | 1 |
| Cheng, ZJ; Ma, L; Pei, G; Wu, YL; Yu, QM | 1 |
| Foxx-Orenstein, AE; Grider, JR; Jin, JG | 1 |
| Abdulla, FA; Smith, PA | 1 |
| Dersch, C; Kubota, H; McCullough, K; Pinto, J; Rice, KC; Rothman, RB | 1 |
| Holtzman, SG; Waddell, AB | 1 |
| Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T | 1 |
| Higashi, H; Kohno, T; Kumamoto, E; Shimoji, K; Yoshimura, M | 1 |
| Dickenson, A; Fitzgerald, M; Hatch, D; Marsh, D | 2 |
| Appleyard, SM; Celver, J; Chavkin, C; Kovoor, A; Pineda, V; Wayman, GA | 1 |
| Chatzaki, E; Dermitzaki, E; Gravanis, A; Margioris, AN | 1 |
| Inoue, M; Ueda, H | 1 |
| McGinty, JF; Tzaferis, JA | 1 |
| Candeletti, S; Collins, S; D'Addario, C; Izenwasser, S; Romualdi, P | 1 |
| Martin-Kleiner, I | 1 |
| Christie, MJ; Connor, M; Marinelli, S; Schnell, SA; Vaughan, CW; Wessendorf, MW | 1 |
| Candeletti, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P | 1 |
| Foster, JA; Graham, D; Perreault, ML; Scattolon, S; Szechtman, H; Wang, Y | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
108 other study(ies) available for enkephalin, leucine and u 69593
| Article | Year |
|---|---|
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach | 1992 |
Synthesis and binding characteristics of the highly delta-specific new tritiated opioid peptide, [3H]deltorphin II.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indicators and Reagents; Isotope Labeling; Kinetics; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1992 |
Protection by opioid ligands against modification of the opioid receptor by a carbodiimide.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain Chemistry; Carbodiimides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Pyrrolidines; Receptors, Opioid | 1992 |
Studies on the effects of glucose in vitro and of the glycaemic state in vivo on the binding characteristics of mu, delta and kappa opiate receptors in mouse brain.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucose; Ligands; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Streptozocin | 1992 |
Characterization of opioid receptors in intestinal muscle cells by selective radioligands and receptor protection.
Topics: Animals; Benzeneacetamides; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Intestinal Mucosa; Ligands; Muscle, Smooth; Osmolar Concentration; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Temperature; Time Factors | 1992 |
Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cell Membrane; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guinea Pigs; Humans; Kinetics; Ligands; Placenta; Pregnancy; Prosencephalon; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid | 1992 |
Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nerve Degeneration; Neurons, Afferent; Oligopeptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Spinal Cord | 1992 |
Opioid receptor agonists and Ca2+ modulation in human B cell lines.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; B-Lymphocytes; Benzeneacetamides; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Humans; Naloxone; Pyrrolidines; Receptors, Opioid; Signal Transduction | 1992 |
Monoarthritis induces complex changes in mu-, delta- and kappa-opioid binding sites in the superficial dorsal horn of the rat spinal cord.
Topics: Animals; Arthritis; Arthritis, Experimental; Autoradiography; Benzeneacetamides; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Freund's Adjuvant; Male; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Infusions, Parenteral; Limbic System; Male; Microinjections; Models, Neurological; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Somatostatin; Tegmentum Mesencephali | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures.
Topics: Animals; Benzeneacetamides; Calcium; Cells, Cultured; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Mesencephalon; Narcotics; Potassium; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1992 |
Opioid delta receptor subtypes are associated with different potassium channels.
Topics: Analgesics; Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Potassium Channels; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Tetraethylammonium Compounds | 1991 |
Morphine-6-glucuronide: receptor binding profile in bovine caudate nucleus.
Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Kinetics; Morphine; Morphine Derivatives; Pyrrolidines; Receptors, Opioid | 1991 |
Opioid binding sites in the guinea pig and rat kidney: radioligand homogenate binding and autoradiography.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Cations; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Kidney; Kinetics; Narcotic Antagonists; Nucleotides; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Tritium | 1991 |
Biochemical characterization and regional quantification of mu, delta and kappa opioid binding sites in rat spinal cord.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Kinetics; Male; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sufentanil; Tritium | 1991 |
Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy.
Topics: Analgesics; Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Ligands; Male; Nervous System Diseases; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Spinal Cord; Sufentanil | 1991 |
Differential effects of two kappa-opiate agonists, U-50,488H and U-69,593, on the binding of 3H-(3-MeHis2) thyrotropin-releasing hormone to rat spinal cord and amygdala membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Enkephalins; Male; Membranes; Pyrrolidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Thyrotropin-Releasing Hormone; Spinal Cord; Thyrotropin-Releasing Hormone | 1991 |
Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro.
Topics: Analgesics; Animals; Animals, Newborn; Astrocytes; Benzeneacetamides; Cells, Cultured; DNA Replication; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Mice, Inbred ICR; Neuroglia; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thymidine | 1991 |
Binding to opioid receptors of enkephalin derivatives taking alpha-helical conformation and its dimer.
Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Brain Chemistry; Cattle; Cell Membrane; Cells, Cultured; Circular Dichroism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Ligands; Lipid Bilayers; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid | 1991 |
Effect of opioid agonists selective for three subclasses of opioid receptors and one sigma receptor agonist on dopamine stimulated adenylate cyclase in rat caudate nucleus.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzeneacetamides; Caudate Nucleus; Cyclic AMP; Dopamine; Dopamine Antagonists; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Genetic influences in opioid analgesic sensitivity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1991 |
Voltage-clamp experiments reveal receptor type-dependent modulation of chloride secretion in the guinea pig colonic mucosa by intestinal opioids.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alprostadil; Amiloride; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gluconates; Guinea Pigs; Intestinal Mucosa; Male; Membrane Potentials; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin; Theophylline | 1991 |
Immunomodulatory activity of mu- and kappa-selective opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibody Formation; Antibody-Producing Cells; Benzeneacetamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunosuppression Therapy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
The novel antagonist profile of (-)metazocine.
Topics: Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphinans; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1990 |
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses.
Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1990 |
Demonstration of the heterogeneity of the kappa-opioid receptors in guinea-pig cerebellum using selective and nonselective drugs.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cerebellum; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
Distribution of mu, delta, and kappa opioid receptor binding sites in the brain of the one-day-old domestic chick (Gallus domesticus): an in vitro quantitative autoradiographic study.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Brain; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Organ Specificity; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1990 |
Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis.
Topics: Analgesics; Animals; Benzeneacetamides; Clonidine; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Regression Analysis; Spinal Cord | 1990 |
Evidence for the presence of mu- and kappa- but not of delta-opioid sites in the human fetal brain.
Topics: Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Male; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1989 |
Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution.
Topics: Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Blood Glucose; Brain Chemistry; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Injections, Intraventricular; Medulla Oblongata; Naloxone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Respiration | 1989 |
Opioid receptors in rat cardiac sarcolemma: effect of phenylephrine and isoproterenol.
Topics: Analgesics; Animals; Benzeneacetamides; Bromides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypotonic Solutions; Isoproterenol; Lithium; Lithium Compounds; Myocardium; Phenylephrine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sarcolemma | 1989 |
Interaction of U-69,593 with mu-, alpha- and kappa-opioid binding sites and its analgesic and intestinal effects in rats.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Male; Naloxone; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid | 1988 |
[3H]U-69593 labels a subtype of kappa opiate receptor with characteristics different from that labeled by [3H]ethylketocyclazocine.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride; Temperature; Tritium | 1988 |
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Selectivity of ligand binding to opioid receptors in brain membranes from the rat, monkey and guinea pig.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain Chemistry; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Haplorhini; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Sufentanil; Tritium | 1988 |
In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice.
Topics: Amino Acid Sequence; Analgesia; Animals; Antibodies; Benzeneacetamides; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunization, Passive; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Female; GTP-Binding Proteins; Naltrexone; Oocytes; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases; Xenopus laevis | 1995 |
14 alpha,14' beta-[Dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis (7,8-dihydromorphinone) and 14 alpha,14' beta-[dithiobis[(2-oxo-2,1- ethanediyl)imino]]bis[7,8-dihydro-N-(cyclopropylmethyl)normorphinone]: chemistry and opioid binding properties.
Topics: Alkylation; Analgesics; Animals; Benzeneacetamides; Cattle; Cell Membrane; Corpus Striatum; Disulfides; Dithiothreitol; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydromorphone; Kinetics; Molecular Structure; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tosylphenylalanyl Chloromethyl Ketone | 1994 |
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Radioligand-binding study of noribogaine, a likely metabolite of ibogaine.
Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; In Vitro Techniques; Kinetics; Naloxone; Pyrrolidines; Radioligand Assay; Receptors, Opioid | 1995 |
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin | 1994 |
Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Codeine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucuronates; Guinea Pigs; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1995 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Characterization of opioid receptors in the Mongolian gerbil cerebellum.
Topics: Animals; Autoradiography; Benzeneacetamides; Binding Sites; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gerbillinae; Guanylyl Imidodiphosphate; In Vitro Techniques; Narcotics; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu | 1994 |
Transient down-regulation of neonatal rat brain mu-opioid receptors upon in utero exposure to buprenorphine.
Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Brain Chemistry; Buprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Membranes; Pregnancy; Prenatal Exposure Delayed Effects; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
The functional role of opioid receptors in acetylcholine release in the rat adrenal medulla.
Topics: Acetylcholine; Adrenal Medulla; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microdialysis; Morphine; Nerve Endings; Physostigmine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Splanchnic Nerves | 1994 |
Selective inhibition of [D-Ala2, Glu4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor.
Topics: Analgesics; Animals; Base Sequence; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Nociceptors; Oligonucleotides, Antisense; Oligopeptides; Pyrrolidines; Receptors, Opioid, delta | 1994 |
Kappa 1 receptor mRNA distribution in the rat CNS: comparison to kappa receptor binding and prodynorphin mRNA.
Topics: Animals; Autoradiography; Benzeneacetamides; Benzomorphans; Brain; Enkephalins; In Situ Hybridization; Protein Precursors; Pyrrolidines; Rats; Receptors, Opioid, kappa; RNA, Messenger; Tissue Distribution | 1994 |
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 1994 |
Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius.
Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Benzeneacetamides; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Medulla Oblongata; Potassium Channels; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synaptic Transmission | 1993 |
Opioid receptor density changes in Alzheimer amygdala and putamen.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Analgesics; Autoradiography; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Frontal Lobe; Humans; Kinetics; Male; Putamen; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Tritium | 1993 |
mu-Opioid receptors modulate noradrenaline release from the rat hippocampus as measured by brain microdialysis.
Topics: Analgesics; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extracellular Space; GTP-Binding Proteins; Hippocampus; Male; Microdialysis; Morphine; Naltrexone; Nerve Endings; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1994 |
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.
Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis | 1993 |
Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Bicuculline; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naltrexone; Narcotics; Oligopeptides; Picrotoxin; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, kappa; Synaptosomes | 1993 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |
Molecular mechanism of delta-selectivity of indole analogs of nonpeptide opioids.
Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Inhibitory effects of NaCl and guanyl-5'yl-imidodiphosphate (GppNHp) on [3H]naloxone binding to kappa-opioid receptors in guinea pig cerebellum.
Topics: Animals; Benzeneacetamides; Binding Sites; Cerebellum; Cerebral Cortex; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Guanylyl Imidodiphosphate; Guinea Pigs; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sodium Chloride | 1993 |
Opioid receptors in midbrain dopaminergic regions of the rat. II. Kappa and delta receptor autoradiography.
Topics: Animals; Autoradiography; Benzeneacetamides; Densitometry; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Image Processing, Computer-Assisted; Male; Mesencephalon; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Substantia Nigra; Tegmentum Mesencephali | 1993 |
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis.
Topics: Analgesics; Animals; Benzeneacetamides; Dialysis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; Male; Micromanipulation; Morphine; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin | 1993 |
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal | 1993 |
Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Binding; Protein Conformation; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1996 |
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Cell Line; Chlorocebus aethiops; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Morphine; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella | 1996 |
Opioid regulation of intracellular free calcium in cultured mouse dorsal root ganglion neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Cells, Cultured; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ganglia, Spinal; Kinetics; Mice; Mice, Inbred C57BL; Neurons; Potassium Chloride; Pyrrolidines; Substance P | 1996 |
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1996 |
Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons.
Topics: Animals; Benzeneacetamides; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1996 |
Evidence for multiple opioid receptors in the human posterior pituitary.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Benzeneacetamides; Binding Sites; Binding, Competitive; Cadaver; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Male; Middle Aged; Narcotics; Oligopeptides; Pituitary Gland, Posterior; Pyrrolidines; Receptors, Opioid; Tissue Distribution | 1996 |
Opioids modulate the cholinergic contraction but not the nonadrenergic relaxation in guinea-pig airways in vitro.
Topics: Animals; Benzeneacetamides; Cholinergic Fibers; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea | 1996 |
Expression of mu-, delta- and kappa-opioid receptors in baculovirus-infected insect cells.
Topics: Adenylyl Cyclases; Animals; Baculoviridae; Benzeneacetamides; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Insecta; Kinetics; Protein Binding; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins | 1996 |
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.
Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared | 1997 |
14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists.
Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Cattle; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, mu; Tritium | 1997 |
A guinea pig ileum preparation devoid of functional kappa receptors: a new in vitro pharmacologic assay for mu-opioid ligands.
Topics: Acetamides; Affinity Labels; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Isothiocyanates; Male; Muscle, Smooth; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Putative kappa-2 opioid agonists are antihyperalgesic in a rat model of inflammation.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1997 |
Conditioned place preference: no tolerance to the rewarding properties of morphine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzeneacetamides; Body Weight; Disease Models, Animal; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraperitoneal; Male; Morphine; Morphine Dependence; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Cardiovascular effects of microinjections of opioid agonists into the 'Depressor Region' of the ventrolateral periaqueductal gray region.
Topics: Analgesics; Animals; Benzeneacetamides; Blood Pressure; Bradycardia; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acids; Heart Rate; Homocysteine; Hypertension; Hypotension; Male; Microinjections; Neural Inhibition; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Syntheses of novel pyridazinomorphinans by inverse electron demand cycloaddition and their binding to mu and kappa receptors.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Cattle; Cell Membrane; Corpus Striatum; Crystallography, X-Ray; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indicators and Reagents; Models, Molecular; Molecular Structure; Morphinans; Pyrazines; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum.
Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
The effects of postmortem delay on mu, delta and kappa opioid receptor subtypes in rat brain and guinea pig cerebellum evaluated by radioligand receptor binding.
Topics: Animals; Benzeneacetamides; Brain; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Kinetics; Male; Naloxone; Postmortem Changes; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1997 |
Binding of [3H][D-Ala2, MePhe4, Gly-ol5] enkephalin, [3H][D-Pen2, D-Pen5]enkephalin, and [3H]U-69,593 to airway and pulmonary tissues of normal and sensitized rats.
Topics: Animals; Asthma; Benzeneacetamides; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypersensitivity, Immediate; Lung; Male; Protein Binding; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory System | 1997 |
Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; Chlorocebus aethiops; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epidermal Growth Factor; GTP-Binding Proteins; Kinetics; Macromolecular Substances; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pertussis Toxin; Pyrrolidines; ras Proteins; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1998 |
Substituted pyrido[3,2-b]oxazin-3(4H)-ones: synthesis and evaluation of antinociceptive activity.
Topics: Analgesics; Animals; Benzeneacetamides; Cimetidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Histamine Antagonists; Male; Mice; Models, Chemical; Nociceptors; Oxazines; Pyridines; Pyrilamine; Pyrrolidines; Receptors, Opioid; Structure-Activity Relationship | 1998 |
Structural features determining differential receptor regulation of neuronal Ca channels.
Topics: Analgesics; Barium; Benzeneacetamides; Calcium Channels; Cell Line; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Channel Gating; Mutagenesis; Naltrexone; Narcotic Antagonists; Neurons; Protein Structure, Tertiary; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Transfection | 1998 |
Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Nerve Fibers; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1998 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
Role of central mu-opioid receptors in the modulation of nitric oxide production by splenocytes.
Topics: Analgesics; Analgesics, Opioid; Animals; Bacterial Toxins; Benzeneacetamides; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enterotoxins; Enzyme Inhibitors; Injections, Intraventricular; Lymphocytes; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Spleen; Superantigens | 1998 |
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons.
Topics: Analgesics; Analgesics, Opioid; Animals; Axotomy; Benzeneacetamides; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Causalgia; Dihydropyridines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Male; Morphine; Nerve Compression Syndromes; Neurons, Afferent; Nociceptin; omega-Conotoxin GVIA; Opioid Peptides; Peptides; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve; Sodium; Spinal Cord | 1998 |
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 1998 |
Modulation of cocaine-induced antinociception by opioid-receptor agonists.
Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa | 1999 |
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection | 1998 |
Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord.
Topics: Animals; Benzeneacetamides; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Opioid Peptides; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Synaptic Transmission | 1999 |
Epidural opioid analgesia in infant rats I: mechanical and heat responses.
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Stress, Mechanical | 1999 |
Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin.
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Capsaicin; Carrageenan; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Subcutaneous; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Agonist-dependent desensitization of the kappa opioid receptor by G protein receptor kinase and beta-arrestin.
Topics: Amino Acid Sequence; Animals; Arrestins; Benzeneacetamides; beta-Arrestin 2; beta-Arrestins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; G-Protein-Coupled Receptor Kinase 3; Molecular Sequence Data; Protein Serine-Threonine Kinases; Pyrrolidines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Opioid, kappa; Structure-Activity Relationship | 1999 |
Opioids transiently prevent activation of apoptotic mechanisms following short periods of serum withdrawal.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Benzeneacetamides; Blotting, Western; Cell Division; Culture Media, Serum-Free; Enkephalin, Leucine; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Membrane Proteins; Narcotic Antagonists; Narcotics; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Rats; Time Factors | 2000 |
Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Blotting, Western; Bradykinin; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enzyme Inhibitors; Male; Mice; Morphine; Nociceptors; Oligonucleotides, Antisense; Pain Measurement; Peripheral Nervous System; Protein Kinase C; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Kappa opioid receptor stimulation decreases amphetamine-induced behavior and neuropeptide mRNA expression in the striatum.
Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Central Nervous System Stimulants; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; In Situ Hybridization; Male; Neuropeptides; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger; Stimulation, Chemical; Substance P | 2001 |
Regulation of dynorphin gene expression by kappa-opioid agonist treatment.
Topics: Animals; Benzeneacetamides; Brain; Enkephalins; Gene Expression; Male; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors; Tissue Distribution | 2002 |
The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells.
Topics: Benzeneacetamides; Cell Division; Cell Survival; Colorimetry; DNA Fragmentation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Humans; Leukemia; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2002 |
delta-opioid receptor-mediated actions on rostral ventromedial medulla neurons.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Calcium Channels; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; In Vitro Techniques; Lysine; Male; Medulla Oblongata; Membrane Potentials; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Serotonin; Substance P; Tryptophan Hydroxylase | 2005 |
Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS.
Topics: Animals; Benzeneacetamides; Blotting, Northern; Central Nervous System; Cocaine; Dynorphins; Enkephalins; Fluoxetine; Hippocampus; Hypothalamus; Male; Neostriatum; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA Probes; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin | 2007 |
Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats.
Topics: Analgesics; Analysis of Variance; Animals; Autoradiography; Basal Ganglia; Benzeneacetamides; Dopamine Agonists; Dopamine Antagonists; Drug Synergism; Enkephalins; Gene Expression; In Situ Hybridization; Injections; Male; Motor Activity; Protein Precursors; Pyrrolidines; Quinpirole; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Opioid, kappa; RNA, Messenger; Sulfur Isotopes; Time Factors | 2007 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |