enkephalin, leucine has been researched along with u-50488 in 349 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 81 (23.21) | 18.7374 |
| 1990's | 241 (69.05) | 18.2507 |
| 2000's | 21 (6.02) | 29.6817 |
| 2010's | 5 (1.43) | 24.3611 |
| 2020's | 1 (0.29) | 2.80 |
| Authors | Studies |
|---|---|
| Argade, MD; Creed, SM; Friesen, JB; Gutridge, AM; Hennessy, MR; Pauli, GF; Riley, AP; van Rijn, RM | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M; Mantelet, S; Mauborgne, A | 1 |
| Capogrossi, MC; Guarnieri, C; Lakatta, EG; Spurgeon, H; Ventura, C | 1 |
| Gintzler, AR; Xu, H | 2 |
| Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L | 1 |
| Collins, KA; Tseng, LF | 3 |
| Madamba, S; Siggins, GR; Yuan, XR | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Levine, JD; Miaskowski, C; Sutters, KA; Taiwo, YO | 3 |
| Eriksson, PS; Hansson, E; Rönnbäck, L | 1 |
| Heller, PH; Levine, JD; Taiwo, YO | 1 |
| Aoki, T; Kamei, J; Kasuya, Y; Kawasima, N; Ohhashi, Y | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 1 |
| Green, PG; Levine, JD | 1 |
| Finberg, RW; Heagy, W; Shipp, MA | 1 |
| Laorden, ML; Micol, JA | 2 |
| Levine, JD; Miaskowski, C | 2 |
| Jin, W; Lee, NM; Loh, HH; Thayer, SA | 2 |
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Johnson, SW; North, RA | 1 |
| Armstead, WM; Leffler, CW; Mirro, R; Zuckerman, SL | 1 |
| Armstead, WM; Crofton, JT; Leffler, CW; Mirro, R; Share, L; Zuckerman, SL | 1 |
| Bot, G; Brent, PJ; Chahl, LA; Johnston, PA | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N | 1 |
| Dubner, R; Iwata, K; Kenshalo, DR; Thomas, DA; Williams, GM | 1 |
| Bot, G; Brent, PJ | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Hamon, M; Legrand, JC; Mauborgne, A | 1 |
| Kavaliers, M; Teskey, GC | 1 |
| Millan, MJ; Morris, BJ | 1 |
| Bridges, RS; Kinsley, CH; Mann, PE | 1 |
| Hoffman, DC; West, TE; Wise, RA | 1 |
| Barr, GA; Carden, SE; Hofer, MA | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Schoffelmeer, AN | 1 |
| Billington, CJ; Grace, M; Levine, AS | 1 |
| Bhargava, HN; Gulati, A; Rahmani, NH | 1 |
| Cheng, J; Pasternak, GW; Paul, D; Pick, CG | 1 |
| Levine, JD; Miaskowski, C; Taiwo, YO | 2 |
| Grider, JR; Makhlouf, GM | 1 |
| Bauer, AJ; Szurszewski, JH | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Kapoor, R; Willoughby, JO | 1 |
| Barnes, PJ; Belvisi, MG; Stretton, CD | 1 |
| Jones, AJ; Keen, P; Ray, NJ | 1 |
| Fox, AJ; Morton, IK | 1 |
| Ferri, S; Lesa, G; Romualdi, P | 1 |
| Fischbach, PS; McCleskey, EW; Schroeder, JE; Zheng, D | 1 |
| Adler, MW; Eisenstein, TK; Geller, EB; Rogers, TJ; Taub, DD | 1 |
| Butt, W; Cowan, A; Fisher, RS; Krevsky, B; Maurer, AH | 1 |
| Cowan, A; Murray, CW | 1 |
| Carr, DB; Cepeda, MS; Lipkowski, AW; Osgood, PF; Silbert, BS; Szyfelbein, SK | 1 |
| Billington, CJ; Grace, M; Levine, AS; Portoghese, PS | 1 |
| Bagetta, G; De Sarro, GB; Nisticò, G; Rispoli, V; Sakurada, S | 1 |
| Buydens, P; Finné, E; Govaerts, J; Matton, A; Vanhaelst, L | 1 |
| Crain, SM; Shen, KF | 2 |
| Arts, KS; Fujimoto, J; Rady, J; Tseng, L | 1 |
| Gosnell, BA; Krahn, DD; Majchrzak, MJ | 1 |
| Amerini, S; Ledda, F; Mantelli, L; Rubino, A | 1 |
| Arts, KS; Fujimoto, JM; Rady, JJ; Tseng, LF | 1 |
| Hoss, W; Periyasamy, S | 1 |
| Hishida, F; Igarashi, O; Luo, CP; Takeshige, C | 1 |
| Burks, TF; Lemcke, PK; Shook, JE | 1 |
| Cone, EJ; Johnson, RE; Su, TP; Vaupel, DB | 1 |
| Barg, J; Hatini, V; Simantov, R | 1 |
| Heijna, MH; Mulder, AH; Schoffelmeer, AN | 1 |
| Bose, R; Glavin, GB; Hall, A; Pinsky, C | 1 |
| Hohmann, AG; Matsumoto, RR; Thompson, LA; Walker, JM | 1 |
| De Vries, TJ; Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Gallo, RV; Mallory, DS | 1 |
| Coombes, JE; Pumford, KM; Russell, JA; Sumner, BE | 1 |
| Attali, B; Barg, J; Simantov, R; Vogel, Z | 1 |
| Fleetwood-Walker, SM; Hope, PJ; Mitchell, R | 1 |
| Burks, TF; Hruby, VJ; Spencer, RL | 2 |
| Burks, TF; Malarchik, ME; Moseberg, HI; Porreca, F; Rivière, PJ; Sheldon, RJ | 1 |
| Chen, HT; Louie, DS; Owyang, C | 1 |
| Yaksh, TL | 1 |
| Echevarria, E; Holaday, JW; Lipkowski, AW; Portoghese, PS; Takemori, AE; Tortella, FC | 1 |
| Herz, A; Millan, MJ; Peter, K; Shippenberg, TS; Stein, C | 1 |
| Fedynyshyn, JP; Kwiat, G; Lee, NM | 1 |
| Burks, TF; Gehrig, CA; Hruby, VJ; Lemcke, PK; Shook, JE | 1 |
| Jackson, HC; Kitchen, I | 1 |
| Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ | 2 |
| Billington, CJ; Gosnell, BA; Grace, M; Levine, AS | 1 |
| Parratt, JR; Sitsapesan, R | 1 |
| Fedynyshyn, JP; Lee, NM | 1 |
| Kelly, MJ; Loose, MD | 1 |
| Cox, BM; McMahon, PN; Werling, LL | 2 |
| Bueno, L; Gué, M; Junien, JL | 2 |
| Brown, DR; Quito, FL | 1 |
| Dewey, WL; Singha, AK; Welch, SP | 1 |
| Hong, EK; Takemori, AE | 1 |
| Grehn, L; Herrera-Marschitz, M; Terenius, L; Ungerstedt, U | 1 |
| Kaneto, H; Kawasaki, K; Maeda, M; Takahashi, M; Watanabe, J | 1 |
| Bhargava, HN; Ramarao, P | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Fujimoto, JM; Roerig, SC | 1 |
| Bals-Kubik, R; Herz, A; Shippenberg, TS | 1 |
| Rooney, KF; Sewell, RD | 1 |
| Gosnell, BA; Majchrzak, MJ | 1 |
| Brown, SR; Cox, BM; Werling, LL | 2 |
| Gratton, A; Jenck, F; Wise, RA | 1 |
| Jenck, F; Quirion, R; Wise, RA | 1 |
| Burks, TF; Hruby, VJ; Pelton, JT; Shook, JE | 1 |
| Porreca, F; Tortella, FC | 1 |
| Smith, CB | 1 |
| Burks, TF; Fox, DA | 1 |
| Bak, TH; Carr, KD | 1 |
| Nunan, L; Porreca, F; Sheldon, RJ | 1 |
| Brinsfield, KH; Matsumoto, RR; Patrick, RL; Walker, JM | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Cox, BM; Frattali, A; Portoghese, PS; Takemori, AE; Werling, LL | 1 |
| Cros, J; Francés, B; Meunier, JC; Porthé, G; Verrier, B | 1 |
| Costa, M; Humphreys, CM; Johnson, SM | 1 |
| Su, TP | 1 |
| Frances, B; Meunier, JC; Moisand, C | 1 |
| Cook, L; Steinfels, GF | 1 |
| Illes, P; Ramme, D | 1 |
| Ishihara, K; Iwama, T; Satoh, M; Takagi, H | 1 |
| Colpaert, FC; Członkowski, A; Herz, A; Höllt, V; Millan, MH; Millan, MJ; Pilcher, CW | 1 |
| Burks, TF; Deupree, D; Hruby, V; Hsiao, S; Mosberg, HI; Porreca, F; Spencer, RL | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Dickenson, AH; Knox, RJ | 1 |
| Russell, NJ; Schaible, HG; Schmidt, RF | 1 |
| De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A | 1 |
| Benyhe, S; Borsodi, A; Hepp, J; Khan, A; Medzihradszky, K; Simon, J; Szücs, M; Wollemann, M | 1 |
| Iyengar, S; Kim, HS; Wood, PL | 1 |
| Belisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Lemaire, S; Petit, A | 1 |
| Bero, LA; Kuhn, CM; Lurie, SN | 1 |
| Alvinerie, M; Bueno, L; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Adler, MW; Geller, EB; Tiseo, PJ | 1 |
| Bueno, L; Fioramonti, J; Gué, M; Junien, JL | 1 |
| Li, CH; Suh, HH; Tseng, LF | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Dreifuss, JJ; Gähwiler, BH; Raggenbass, M; Wuarin, JP | 1 |
| Faden, AI; Feuerstein, G; Powell, E | 1 |
| Carter, DA; Lightman, SL | 1 |
| Benton, D | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 1 |
| Herz, A; Morris, BJ | 1 |
| Leadem, CA; Yagenova, SV | 1 |
| Dunwiddie, TV; Johnson, KJ; Proctor, WR | 1 |
| Fukushima, N; Misawa, H; Takagi, H; Ueda, H | 1 |
| Lee, NM; Loh, HH; Roy, S; Zhu, YX | 1 |
| Bueno, L; Fioramonti, J; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Innes, DG; Kavaliers, M | 1 |
| Burks, TF; Hruby, VJ; Hurst, R; Mosberg, HI; Porreca, F | 1 |
| Bardon, T; Pairet, M; Ruckebusch, Y | 1 |
| Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 1 |
| Pairet, M; Ruckebusch, Y | 1 |
| Neil, A | 1 |
| Brown, MJ; Conway, EL; Dollery, CT | 1 |
| Laorden, ML; Llobell, F | 1 |
| Cadet, JL; Elmer, GI; Epstein, CJ; Evans, JL; Ladenheim, B | 1 |
| Capasso, A; Carnuccio, R; D'Acquisto, F; Iuvone, T | 1 |
| Choi, YS; Kim, YH; Sim, YB; Song, DK; Suh, HW | 1 |
| Bachelard, H; Pître, M | 1 |
| Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
| Dragatsis, I; Gerozissis, K; Papazafiri, P; Zioudrou, C | 1 |
| Bass, PP; Welch, SP | 1 |
| Chen, C; Chen, YW; Kim de Riel, J; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M | 1 |
| Collins, JG; Harada, Y; Kitahata, LM; Nakatani, K; Nishioka, K | 1 |
| Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K | 1 |
| Abbott, FV; Hong, Y | 1 |
| Kudernatsch, MB; Schlösser, B; Sutor, B; ten Bruggencate, G | 1 |
| Nicosia, F; Rehder, K; Rocchi, D; Song, P; Zappi, L | 1 |
| Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Petit, A | 1 |
| Ableitner, A; Hassan, AH; Herz, A; Stein, C | 1 |
| Devine, DP; Leone, P; Pocock, D; Wise, RA | 1 |
| Baghdoyan, HA; Cronin, A; Keifer, JC; Lydic, R | 1 |
| Paul, D; Tran, JG | 1 |
| Hinson, JP; Kapas, S; Purbrick, A | 1 |
| Badiani, A; Leone, P; Noel, MB; Stewart, J | 1 |
| Alarcón, S; Hernández, J; Laorden, ML | 1 |
| Coenen, A; Lasoń, W; Machelska, H; Przewłocka, B; Przewłocki, R; van Luijtelaar, G | 1 |
| Tseng, LF; Xu, JY | 1 |
| Kim, YH; Song, DK; Suh, HW; Tseng, LF; Yoo, JS | 1 |
| Henriksen, SJ; Mayer, JH; Steffensen, SC | 1 |
| Garaulet, JV; Laorden, ML; Milanés, MV | 3 |
| Nagasaka, H; Yaksh, TL | 1 |
| Bodnar, RJ; Pasternak, GW; Rossi, GC | 1 |
| Ichikawa, T; Ikeda, K; Kobayashi, T; Kumanishi, T; Usui, H | 1 |
| Capasso, A; Di Giannuario, A; Domenici, MR; Loizzo, A; Pieretti, S; Sagratella, S; Sorrentino, L | 1 |
| Mitrovic, I; Napier, TC | 1 |
| Madamba, SG; Moore, SD; Schweitzer, P; Siggins, GR | 1 |
| Campana, G; Guarnieri, C; Pintus, G; Spampinato, S; Vaona, I; Ventura, C | 1 |
| Inenaga, K; Nagatomo, T; Nakao, K; Yamashita, H; Yanaihara, N | 1 |
| Holtzman, SG; Jones, DN | 1 |
| Jauzac, P; Polastron, J | 1 |
| Collins, KA; Kampine, JP; Tseng, LF | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Legrand, JC; Mauborgne, A | 1 |
| Brent, PJ; Bunn, SJ | 1 |
| Chien, CC; Pasternak, GW | 1 |
| Das, D; Michael-Titus, AT; Rogers, J | 1 |
| Chen, CY; Hwang, CL; Tao, PL | 1 |
| Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H | 1 |
| Demura, H; Hotta, M; Imaki, T; Ling, N; Shibasaki, T | 1 |
| Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Venier, I | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Bicknell, RJ; Douglas, AJ; Dye, S; Leng, G; Russell, JA | 1 |
| North, RA; Sugita, S | 1 |
| Kaneko, S; Katao, Y; Maekawa, K; Minami, M; Nakamura, S; Onogi, T; Satoh, M; Toya, T | 1 |
| Adloff, M; Angel, F; Chamouard, P; Klein, A; Martin, E | 1 |
| D'Alecy, LG; Mayfield, KP | 1 |
| Fujina, M; Kojima, Y; Owyang, C; Takahashi, T | 1 |
| Martin, BR; Smith, PB; Welch, SP | 1 |
| Baumeister, AA; Chaney, TM; Curtis, W; Hurry, M; Leoni, RR; Wolf, E | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Brown, G; Chien, CC; Pan, YX; Pasternak, GW | 1 |
| Fu, R; Gaskill, MB; Iwasaki, Y; Robertson, GL; Saper, CB | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H | 1 |
| DeHaven-Hudkins, DL; Komer, KM; Mavunkel, BJ; Peterson, JA; Rzeszotarski, WJ | 1 |
| Dosaka-Akita, K; Holaday, JW; Long, JB; Tortella, FC | 1 |
| Bültmann, R; Driessen, B; Starke, K; von Kügelgen, I | 1 |
| Baumhaker, Y; Goldstein, MN; Sarne, Y; Wollman, Y | 1 |
| Collins, KA; Portoghese, PS; Tseng, LF | 1 |
| Welch, SP | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M | 1 |
| Bakshi, VP; Kelley, AE | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Abood, ME; Pugh, G; Welch, SP | 1 |
| Borgbjerg, FM; Frigast, C; Madsen, JB; Mikkelsen, LF | 1 |
| Brandão, ML; Motta, V; Penha, K | 1 |
| Choi, YS; Kim, YH; Song, DK; Suh, HW | 1 |
| Danzebrink, RM; Gebhart, GF; Green, SA | 1 |
| Coupar, IM | 1 |
| Chaplan, SR; Lee, YW; Yaksh, TL | 1 |
| Capasso, A; Di Giannuario, A; Loizzo, A; Pieretti, S; Sagratella, S; Sorrentino, L | 1 |
| Morgan, EL | 1 |
| Alfaro, MJ; Goicoechea, C; Martin, MI; Ormazabal, MJ | 2 |
| Clarke, IJ; Walsh, JP | 1 |
| Eason, MG; Francis, RS; Kuhn, CM | 1 |
| Kar, S; Ménard, DP; Quirion, R; van Rossum, D | 1 |
| Bronson, JB; Chen, DY; Koob, GF; Motis, V; Vankova, ME; Weinger, MB | 1 |
| Belknap, JK; Grandy, DK; Grisel, JE; Mogil, JS; Zhangs, G | 1 |
| Bot, G; Chahl, LA | 1 |
| Blake, DR; Earl, JR; Grootveld, MC; Morris, CJ | 1 |
| Deviche, P; Ebbesson, LO; Ebbesson, SO | 1 |
| Choi, SR; Kim, YH; Lee, KJ; Song, DK; Suh, HW | 1 |
| Choi, SR; Chung, KM; Kim, YH; Song, DK; Suh, HW | 1 |
| Allard, M; Jordan, D; Kopp, N; Martin, D; Ries, C; Simonnet, G; Tafani, JA; Zajac, JM | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Yuan, CS | 1 |
| Bhargava, HN; Bian, JT | 1 |
| Kamei, J; Kawai, K; Mizoguchi, H; Mizusuna, A; Nagase, H; Narita, M; Suzuki, T; Tseng, LF | 1 |
| Peter, Y; Pick, CG; Schreiber, S; Weizman, R | 1 |
| Pintus, G; Ventura, C | 1 |
| Kampine, JP; Mizoguchi, H; Narita, M; Tseng, LF | 1 |
| Choi, YS; Kim, YH; Song, DK; Suh, HW; Tseng, LF; Yoo, JS | 1 |
| Bodnar, RJ; Ruegg, H; Yu, WZ | 1 |
| Soong, Y; Szeto, HH; Taylor, CC; Wu, D; Yee, JS | 1 |
| Bhargava, HN; Cao, YJ; Zhao, GM | 2 |
| Bhargava, HN; Cao, YJ | 3 |
| Capasso, A; Sorrentino, L | 1 |
| Kishimoto, Y; Maeda, J; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Kuraishi, Y; Tohda, C; Yamaguchi, T | 1 |
| Nicosia, F; Nicosia, S; Rehder, K; Song, P; Zappi, L | 1 |
| Chen, C; Li, JG; Liu-Chen, LY; Luo, LY; Zhu, J | 1 |
| Labuz, D; Machelska, H; Przewłocka, B; Przewłocki, R | 1 |
| Rothe, KS; Stevens, CW | 1 |
| Chakrabarti, S; Jin, W; Law, PY; Loh, HH; Spencer, RJ; Thayer, SA | 1 |
| Childers, SR; Sim, LJ | 1 |
| Inturrisi, CE; Kao, B; Kest, B; McLemore, G | 1 |
| Calò, L; Carmenini, E; Orzi, F; Passarelli, F; Pontieri, FE | 1 |
| Jain, S; Kolesnikov, Y; Pasternak, GW; Wilson, R | 1 |
| Herlenius, EA; Lindahl, SG; Takita, K; Yamamoto, Y | 1 |
| Dierich, A; Kieffer, BL; Kitchen, I; Le Meur, M; Maldonado, R; Roques, BP; Simonin, F; Slowe, S; Smadja, C; Valverde, O | 1 |
| Hauser, KF; Stiene-Martin, A; Zhou, R | 1 |
| Carney, JM; Harris-White, ME; Hauser, KF; Jackson, JA; Opanashuk, LA | 1 |
| Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W | 1 |
| Liu, HC; Loh, HH; Roy, S | 1 |
| Endoh, T; Suzuki, T | 1 |
| Dichter, MA; Reisine, T; Tallent, M | 1 |
| Omoniyi, AT; Soong, Y; Szeto, HH; Wu, D | 1 |
| Carbone, E; Clementi, F; Codignola, A; Missale, C; Sher, E; Spano, P | 1 |
| Herlenius, E; Lindahl, SG; Takita, K; Yamamoto, Y | 1 |
| Nozaki-Taguchi, N; Yamamoto, T | 1 |
| Fukuda, K; Kato, S; Mima, H; Mori, K; Morikawa, H; Shoda, T | 1 |
| Boudinot, E; Denavit-Saubié, M; Foutz, AS; Kieffer, BL; Maldonado, R; Matthes, HW; Negri, L; Roques, BP; Severini, C; Smadja, C; Valverde, O; Vonesch, JL | 1 |
| Flamigni, F; Pignatti, C; Rossoni, C; Stanic, I; Stefanelli, C; Tantini, B | 1 |
| Hata, F; Nishio, H; Nishiwaki, H; Saitoh, N; Takeuchi, T | 1 |
| Andoh, T; Ito, H; Kamiya, Y; Oka, K; Watanabe, I | 1 |
| Osumi, Y; Yokotani, K | 1 |
| Yuan, XR | 1 |
| Capasso, A; Pinto, A; Sorrentino, L | 1 |
| Joshi, S; Lee, JW; Wong, YH | 1 |
| Fuchs, PN; Raja, SN; Roza, C; Sora, I; Uhl, G | 1 |
| Mizoguchi, H; Narita, M; Sora, I; Tseng, LF; Uhl, GR | 1 |
| Kowalski, J | 2 |
| Albrecht, E; Berger, H; Bienert, M; Wallukat, G | 1 |
| Hallermann, S; Müller, W; Swandulla, D | 1 |
| Foss, JF; Yuan, CS | 1 |
| Gerfen, CR; Steiner, H | 1 |
| Cao, XD; Cui, DF; Li, MY; Qi, ZW; Wu, GC; Xu, SF; Zhang, XL; Zhu, CB | 1 |
| Banks, WA; Brown, TT; Kastin, AJ; Maresh, GA; Zadina, JE | 1 |
| Gafni, M; Keren, O; Sarne, Y | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Beslot, F; Ledent, C; Parmentier, M; Roques, BP; Valverde, O | 1 |
| Bereiter, DA; Hirata, H; Hu, JW; Takeshita, S | 1 |
| Amico, JA; Brown, DC; Perkowski, SZ; Shofer, F | 1 |
| Fiore, P; Gannon, RL; Tierno, A | 1 |
| Gallo, RV; Zhang, Q | 1 |
| Bogacka, I; Kaminski, T; Okrasa, S; Przala, J; Siawrys, G | 1 |
| Bogacka, I; Kaminski, T; Okrasa, S; Przala, J; Siawrys, C | 1 |
| Baba, S; Hiramatsu, M; Kojima, R; Nabeshima, T; Watanabe, M | 1 |
| Lam, HA; Maidment, NT; Narayanan, S; Shoblock, J; Skoubis, PD | 1 |
| Chavkin, C; Land, BB; Li, S; McLaughlin, JP; Pintar, JE | 1 |
| Adrian, R; Baratta, J; Koob, GF; Lauterborn, JC; Solbrig, MV | 1 |
| Aguilar, E; Bové, J; Cortés, R; Marin, C; Mengod, G; Serrats, J | 1 |
| Buxbaum, JD; Cho, J; Jacobson, DA; Landa, LR; Philipson, LH; Roe, MW; Tamarina, NA | 1 |
| Herzog, H; Loacker, S; Sayyah, M; Schwarzer, C; Wittmann, W | 1 |
| Bruchas, MR; Chavkin, C; Land, BB; Lemos, JC; Melief, EJ; Xu, M | 1 |
| Chavkin, C; Redila, VA | 1 |
| Gaburro, S; Herzog, H; Rosskothen, I; Schunk, E; Schwarzer, C; Singewald, N; Wittmann, W | 1 |
| Bolte, C; Newman, G; Schultz, Jel J | 1 |
| Carey, AN; Dunton, O; Lyons, AM; McLaughlin, JP; Shay, CF | 1 |
| Bing, G; Jang, CG; Kim, HC; Koo, KH; Nabeshima, T; Oh, CH; Oh, KW; Park, DH; Shin, EJ; Yamada, K | 1 |
| Carey, AN; Gomes, SM; McLaughlin, JP; Sperling, RE; Sypek, EI | 1 |
| Chavkin, C; Reyes, BA; Van Bockstaele, EJ | 1 |
| Aigner, C; Herzog, H; Schunk, E; Schwarzer, C; Stefanova, N; Wenning, G | 1 |
| Bilkei-Gorzo, A; Mauer, D; Michel, K; Zimmer, A | 1 |
| Abbruscato, TJ; Islam, MR; Karamyan, VT; Yang, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
2 review(s) available for enkephalin, leucine and u-50488
| Article | Year |
|---|---|
Striatonigral prodynorphin: a model system for understanding opioid peptide function.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Dopamine; Enkephalins; Hydroxydopamines; Locomotion; Motor Neurons; Movement; Naloxone; Neural Pathways; Oxidopamine; Protein Precursors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Substantia Nigra | 1990 |
Functional response of multiple opioid systems to chronic arthritic pain in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arthritis; Arthritis, Experimental; Benzomorphans; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Morphine; Naloxone; Nociceptors; Pain; Pituitary Gland, Anterior; Protein Precursors; Pyrrolidines; Rats; Receptors, Opioid; Sensory Thresholds; Spinal Cord; Thalamus | 1986 |
347 other study(ies) available for enkephalin, leucine and u-50488
| Article | Year |
|---|---|
Isolation and Pharmacological Characterization of Six Opioidergic
Topics: Alkaloids; Analgesics; Animals; Apocynaceae; Indoles; Receptors, Opioid, kappa; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Seeds; Terpenes | 2021 |
Kappa-/mu-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Male; Models, Neurological; Naloxone; Naltrexone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 1992 |
Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Electric Stimulation; Enkephalins; Homeostasis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Myocardial Contraction; Myocardium; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil | 1992 |
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach | 1992 |
The tail-flick inhibition induced by beta-endorphin administered intrathecally is mediated by activation of kappa- and mu-opioid receptors in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Methysergide; Mice; Mice, Inbred ICR; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yohimbine | 1992 |
Opioid peptides reduce synaptic transmission in the nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Naloxone; Neurons; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synapses; Synaptic Transmission | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Antinociceptive and motor effects of delta/mu and kappa/mu combinations of intrathecal opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Motor Activity; Nociceptors; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Delta and kappa opiate receptors in primary astroglial cultures. Part II: Receptor sets in cultures from various brain regions and interactions with beta-receptor activated cyclic AMP.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Animals; Astrocytes; Brain Stem; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Isoproterenol; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes | 1992 |
Streptozotocin-induced diabetes selectively alters the potency of analgesia produced by mu-opioid agonists, but not by delta- and kappa-opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Ventricles; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Opioid receptor-mediated inhibition of 3H-dopamine and 14C-acetylcholine release from rat nucleus accumbens slices. A study on the possible involvement of K+ channels and adenylate cyclase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adenylyl Cyclases; Analgesics; Animals; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nucleus Accumbens; Potassium Channels; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1992 |
Modulation of kappa-mediated antitussive activity in rats by a delta-agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Cough; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reflex | 1992 |
Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Bradykinin; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Joints; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Opioid receptor agonists and Ca2+ modulation in human B cell lines.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; B-Lymphocytes; Benzeneacetamides; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Humans; Naloxone; Pyrrolidines; Receptors, Opioid; Signal Transduction | 1992 |
Interaction between halothane and mu, delta and kappa opioid agonists on the isolated right atria of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Atrial Function; Culture Techniques; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Halothane; Heart Rate; Male; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1992 |
Antinociception produced by receptor selective opioids: modulation of spinal antinociceptive effects by supraspinal opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1992 |
Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Bucladesine; Calcium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Ion Channel Gating; Narcotics; Neuroblastoma; Phorbol 12,13-Dibutyrate; Pyrrolidines; Receptors, Opioid, delta; Tumor Cells, Cultured | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Opioids excite dopamine neurons by hyperpolarization of local interneurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Bicuculline; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Mesencephalon; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses | 1992 |
Vasopressin modulates cerebrovascular responses to opioids in newborn pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Arginine Vasopressin; Brain; Dynorphins; Endorphins; Enkephalins; Female; Male; Pyrrolidines; Receptors, Opioid; Swine; Vasoconstriction | 1992 |
Influence of opioids on CSF vasopressin concentration in newborn pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analysis of Variance; Animals; Animals, Newborn; beta-Endorphin; Cerebral Arteries; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Naloxone; Pyrrolidines; Swine; Vasopressins | 1992 |
Effects of intracerebroventricularly administered mu-, delta- and kappa-opioid agonists on locomotor activity of the guinea pig and the pharmacology of the locomotor response to U50,488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Hypnotics and Sedatives; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Motor Activity; Narcotics; Peptide Fragments; Piloerection; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Inhibition of spinal opioid analgesia by supraspinal administration of selective opioid antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Narcotic Antagonists; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Somatostatin | 1992 |
Paradoxical analgesia produced by naloxone in diabetic mice is attributable to supersensitivity of delta-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Pain; Pain Measurement; Pyrrolidines; Reaction Time; Time Factors | 1992 |
Effects of central administration of opioids on facial scratching in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Face; Injections, Spinal; Macaca fascicularis; Male; Microinjections; Narcotics; Pruritus; Pyrrolidines; Spinal Cord | 1992 |
Morphine, D-Pen2, D-Pen5 enkephalin and U50,488H differentially affect the locomotor activity and behaviours induced by quinpirole in guinea-pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; Female; Guinea Pigs; Hypnotics and Sedatives; Injections, Intraventricular; Male; Morphine; Motor Activity; Piloerection; Pyrrolidines; Quinpirole | 1992 |
Differential inhibitory/stimulatory modulation of spinal CCK release by mu and delta opioid agonists, and selective blockade of mu-dependent inhibition by kappa receptor stimulation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cholecystokinin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Male; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Modifications of social conflict-induced analgesic and activity responses in male mice receiving chronic opioid agonist and antagonist treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Conflict, Psychological; Enkephalin, Leucine; Infusion Pumps, Implantable; Levorphanol; Male; Mice; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Receptors, Opioid; Social Behavior; Sodium Chloride | 1991 |
Inability of an opioid antagonist lacking negative intrinsic activity to induce opioid receptor up-regulation in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Binding, Competitive; Drinking; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Sensory Thresholds; Up-Regulation | 1991 |
Opioid receptor subtype involvement in maternal behavior in lactating rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Lactation; Maternal Behavior; Morphine; Phenazocine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Ventral pallidal microinjections of receptor-selective opioid agonists produce differential effects on circling and locomotor activity in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Functional Laterality; Globus Pallidus; Male; Microinjections; Motor Activity; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior; Time Factors | 1991 |
Differential effects of specific opioid receptor agonists on rat pup isolation calls.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Social Isolation; Ultrasonics; Vocalization, Animal | 1991 |
Opioid-receptor-mediated inhibition of [3H]dopamine but not [3H]noradrenaline release from rat mediobasal hypothalamus slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dopamine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ergolines; Hypothalamus, Middle; Male; Naloxone; Narcotic Antagonists; Norepinephrine; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Beta-funaltrexamine (beta-FNA) decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Feeding Behavior; Food Deprivation; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Differential effects of two kappa-opiate agonists, U-50,488H and U-69,593, on the binding of 3H-(3-MeHis2) thyrotropin-releasing hormone to rat spinal cord and amygdala membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Enkephalins; Male; Membranes; Pyrrolidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Thyrotropin-Releasing Hormone; Spinal Cord; Thyrotropin-Releasing Hormone | 1991 |
Genetic influences in opioid analgesic sensitivity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1991 |
Contribution of supraspinal mu- and delta-opioid receptors to antinociception in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Narcotic Antagonists; Nociceptors; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Identification of opioid receptors on gastric muscle cells by selective receptor protection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Stomach | 1991 |
Effect of opioid peptides on circular muscle of canine duodenum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Muscles; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid | 1991 |
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes | 1991 |
Activation of mu opioid receptors in the pre-optic-anterior hypothalamus releases prolactin in the conscious male rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anterior Hypothalamic Nucleus; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Preoptic Area; Prolactin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Modulation of cholinergic neurotransmission in guinea-pig airways by opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Bronchi; Capsaicin; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Narcotics; Parasympathetic Nervous System; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance P; Synaptic Transmission; Trachea | 1990 |
Morphine, but not sodium cromoglycate, modulates the release of substance P from capsaicin-sensitive neurones in the rat trachea in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Bradykinin; Capsaicin; Cromolyn Sodium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Neurons; Potassium Chloride; Pyrrolidines; Rats; Rats, Inbred Strains; Substance P; Trachea | 1991 |
Mu and kappa opioid receptor modulation of 5-HT3 and NK-3 receptor-evoked release of acetylcholine from the guinea-pig ileum myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Choline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptide Fragments; Pyrrolidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Serotonin; Receptors, Tachykinin; Serotonin; Substance P; Tritium | 1991 |
Chronic opiate agonists down-regulate prodynorphin gene expression in rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Blotting, Northern; Brain Chemistry; Corpus Striatum; DNA Probes; Down-Regulation; Enkephalins; Gene Expression Regulation; Hippocampus; Hypothalamus; Male; Morphine; Narcotics; Protein Precursors; Pyrrolidines; Rats; Rats, Inbred Strains; RNA, Messenger | 1991 |
Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle, Smooth; Myenteric Plexus; Narcotics; Pertussis Toxin; Pyrrolidines; Sufentanil; Virulence Factors, Bordetella | 1991 |
Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Mollusk Venoms; Naltrexone; Narcotic Antagonists; omega-Conotoxin GVIA; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Immunomodulatory activity of mu- and kappa-selective opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibody Formation; Antibody-Producing Cells; Benzeneacetamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunosuppression Therapy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Effects of selective opioid agonists on feline colonic transit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cattle; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Loperamide; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil | 1991 |
Enhanced potency of receptor-selective opioids after acute burn injury.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; beta-Endorphin; Burns; Corticosterone; Dose-Response Relationship, Drug; Enkephalins; Injections, Intravenous; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains | 1991 |
Comparison of the antinociceptive and motor effects of intrathecal opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Narcotic Antagonists; Pain; Postural Balance; Psychomotor Performance; Pyrrolidines; Rats; Rats, Inbred Strains; Sensory Thresholds | 1991 |
Nor-binaltorphimine decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Food Deprivation; Male; Naltrexone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Reference Values | 1990 |
Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Dextromethorphan; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ketamine; Locus Coeruleus; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Opioid Peptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1990 |
The growth hormone secretory response to fentanyl in rat: an involvement of mu type receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Leucine; Fentanyl; Growth Hormone; Male; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Dynorphin prolongs the action potential duration of mouse sensory ganglion neurons by decreasing a K+ conductance whereas the specific kappa opioid, U-50,488H does so by increasing a Ca2+ conductance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dynorphins; Electric Conductivity; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; In Vitro Techniques; Mice; Neurons; Potassium Channels; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Intracerebroventricular analgesia enhanced by intrathecal (IT) dynorphin A(1-17) antibody.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Physostigmine; Pyrrolidines | 1990 |
Dynorphin prolongs the action potential of mouse sensory ganglion neurons by decreasing a potassium conductance whereas another specific kappa opioid does so by increasing a calcium conductance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ganglia, Spinal; In Vitro Techniques; Mice; Narcotics; Neural Conduction; Neurons; Potassium; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Effects of preferential delta and kappa opioid receptor agonists on the intake of hypotonic saline.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drinking; Dynorphins; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Food Preferences; Hypotonic Solutions; Injections, Intraventricular; Male; Oligopeptides; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Taste | 1990 |
Characterization of opioid receptors modulating the function of capsaicin-sensitive neurons in guinea-pig atria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Benzomorphans; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Male; Morphine; Neurons; Pyrrolidines; Receptors, Opioid; Reserpine | 1990 |
Spinal dynorphin A (1-17): possible mediator of antianalgesic action.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Nociceptors; Physostigmine; Pyrrolidines; Spinal Cord | 1990 |
Kappa opioid receptors stimulate phosphoinositide turnover in rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Dynorphins; Enkephalins; Ethylketocyclazocine; Male; Phosphatidylinositols; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Analgesic synergy and improved motor function produced by combinations of mu-delta- and mu-kappa-opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Narcotics; Psychomotor Performance; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Differentiation of acupuncture and nonacupuncture points by difference of associated opioids in the spinal cord in production of analgesia by acupuncture and nonacupuncture point stimulation, and relations between sodium and those opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acupuncture Analgesia; Acupuncture Points; Analgesics; Animals; Benzomorphans; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride; Spinal Cord | 1990 |
Spinally mediated opioid antidiarrheal effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidiarrheals; Body Weight; Diarrhea; Dinoprostone; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Pyrrolidines; Spinal Cord | 1991 |
Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amino Acid Sequence; Animals; Diuresis; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Naltrexone; Oligopeptides; Phenazocine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens | 1990 |
Developmental pattern of opioid receptors in the striatum and hippocampus: evidence for a non-mature type of receptor in embryonic tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hippocampus; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Regional differences in opioid receptor-mediated inhibition of dopamine and acetylcholine release in the rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Brain; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Pyrrolidines; Rats; Receptors, Opioid; Tissue Distribution | 1990 |
Opioid involvement in epileptogenic and neurovisceral activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Digestive System; Enkephalin, Leucine; Enkephalin, Methionine; Epilepsy; Kainic Acid; Male; Mice; Naloxone; Nervous System; Pyrrolidines; Receptors, Opioid | 1990 |
Kappa- and delta-opioid agonists synergize to produce potent analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1990 |
Ontogeny of mu-, delta- and kappa-opioid receptors mediating inhibition of neurotransmitter release and adenylate cyclase activity in rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adenylyl Cyclases; Aging; Animals; Brain; Catecholamines; Electric Stimulation; Embryonic and Fetal Development; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
Medial preoptic-anterior hypothalamic area involvement in the suppression of pulsatile LH release by a mu-opioid agonist in the ovariectomized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anterior Hypothalamic Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Kinetics; Luteinizing Hormone; Ovariectomy; Preoptic Area; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors | 1990 |
Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Female; Injections, Intraventricular; Morphine; Pituitary Gland, Posterior; Plasma; Preoptic Area; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1990 |
Differential effect of mu, delta, and kappa ligands on G protein alpha subunits in cultured brain cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cells, Cultured; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rhombencephalon; Signal Transduction; Telencephalon; Up-Regulation | 1990 |
Distinct antinociceptive actions mediated by different opioid receptors in the region of lamina I and laminae III-V of the dorsal horn of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Neurons; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1990 |
Alteration of thermoregulatory set point with opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature Regulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains | 1990 |
Opioid regulation of mucosal ion transport in the mouse isolated jejunum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Biological Transport; Chlorides; Electrolytes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Intestinal Mucosa; Jejunum; Mice; Morphine; Pyrrolidines; Sodium | 1990 |
Inhibition of exocrine pancreatic secretion by opiates is mediated by suppression of cholinergic transmission: characterization of receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Amylases; Animals; Cholinergic Fibers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Narcotics; Pancreas; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptic Transmission | 1988 |
Substance P release from knee joint afferent terminals: modulation by opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Afferent Pathways; Animals; Capsaicin; Cats; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Hindlimb; Joints; Narcotics; Pyrrolidines; Reference Values; Sciatic Nerve; Substance P; Sufentanil | 1988 |
Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Seizures | 1989 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds | 1989 |
Characterization of high affinity opioid binding sites in rat periaqueductal gray P2 membrane.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Membranes; Periaqueductal Gray; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antidiarrheals; Constipation; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Behavioural effects of selective mu-, kappa-, and delta-opioid agonists in neonatal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesics; Animals; Animals, Newborn; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Morphine; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Delta opioid antagonist, 16-Me cyprenorphine, selectively attenuates conditional fear- and DPDPE-induced analgesia on the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fear; Female; Formaldehyde; Injections, Intraventricular; Morphinans; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Effects of streptozotocin-induced diabetes on feeding stimulated by centrally administered opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
The effects of drugs interacting with opioid receptors on the early ventricular arrhythmias arising from myocardial ischaemia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Coronary Vessels; Enkephalin, Leucine; Heart Rate; Heroin; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1989 |
Mu type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to G-protein-mediated inhibition of adenylyl cyclase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; In Vitro Techniques; Periaqueductal Gray; Pertussis Toxin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1989 |
Opioid inhibition of spontaneously active neurons of the rat arcuate nucleus in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Arcuate Nucleus of Hypothalamus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; In Vitro Techniques; Neural Inhibition; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
Effects of pertussis toxin on opioid regulation of catecholamine release from rat and guinea pig brain slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Catecholamines; Corpus Striatum; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Male; Narcotics; Pertussis Toxin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1989 |
Central and peripheral opioid modulation of gastric relaxation induced by feeding in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Dogs; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Morphine; Muscle Relaxation; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagotomy; Vagus Nerve | 1989 |
Jejunal proabsorptive actions of selective opiate agonists administered via the cerebral ventricles.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Animals; Body Water; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Intestinal Absorption; Jejunum; Kinetics; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
The antinociception produced by intrathecal morphine, calcium, A23187, U50,488H, [D-Ala2, N-Me-Phe4, Gly-ol]enkephalin and [D-Pen2, D-Pen5]enkephalin after intrathecal administration of calcitonin gene-related peptide in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Calcimycin; Calcitonin Gene-Related Peptide; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Morphine; Pyrrolidines; Receptors, Opioid; Spinal Cord | 1989 |
Indirect involvement of delta opioid receptors in cholecystokinin octapeptide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Sincalide | 1989 |
Rotational behaviour produced by intranigral injections of bovine and human beta-casomorphins in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Injections; Male; Mitochondria; Morphine; Muscle, Smooth; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Rotation; Stereotyped Behavior; Substantia Nigra | 1989 |
Selectivity for opioid receptor subtypes of enkephalin analogues in isolated smooth muscle and in the analgesic effect in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Electric Stimulation; Enkephalins; Guinea Pigs; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid | 1989 |
Antagonism of kappa opioid mediated effects in the rat by cyclo(Leu-Gly).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Cortex; Cyclazocine; Diuresis; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Neuropeptides; Peptides, Cyclic; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid | 1989 |
Evidence that the aversive effects of opioid antagonists and kappa-agonists are centrally mediated.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Conditioning, Operant; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin | 1989 |
Evaluation of selective actions of dopamine D-1 and D-2 receptor agonists and antagonists on opioid antinociception.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dopamine Agents; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ergolines; Fentanyl; Injections, Intraventricular; Male; Mice; Narcotics; Nociceptors; Pyrrolidines; Quinpirole; Reaction Time; Receptors, Dopamine; Sufentanil; Sulpiride | 1989 |
Centrally administered opioid peptides stimulate saccharin intake in nondeprived rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Food Preferences; Male; Naloxone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Saccharin; Time Factors | 1989 |
Opioid receptor regulation of the release of norepinephrine in brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Models, Neurological; Naloxone; Norepinephrine; Potassium; Pyrrolidines; Receptors, Opioid | 1987 |
Opioid receptor subtypes associated with ventral tegmental facilitation of lateral hypothalamic brain stimulation reward.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypothalamic Area, Lateral; Male; Morphine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward | 1987 |
Opioid receptor subtypes associated with ventral tegmental facilitation and periaqueductal gray inhibition of feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Hypothalamic Area, Lateral; Male; Morphine; Periaqueductal Gray; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tegmentum Mesencephali | 1987 |
Peptide opioid antagonist separates peripheral and central opioid antitransit effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Differential antagonism of mu agonists by U50,488H in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; Male; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Urinary Bladder | 1987 |
Effects of prior exposure to morphine on the opioid inhibition of the stimulated release of [3H]norepinephrine from guinea pig cortex slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Morphine; Morphine Dependence; Norepinephrine; Pyrrolidines; Receptors, Opioid | 1986 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Medial thalamic injection of opioid agonists: mu-agonist increases while kappa-agonist decreases stimulus thresholds for pain and reward.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Infusions, Parenteral; Male; Microinjections; Naloxone; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Self Stimulation; Thalamus | 1988 |
U50,488H differentially antagonizes the bladder effects of mu agonists at spinal sites.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Morphine Derivatives; Muscle Contraction; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1988 |
Rotational behavior mediated by dopaminergic and nondopaminergic mechanisms after intranigral microinjection of specific mu, delta and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydroxydopamines; Male; Microinjections; Motor Activity; Naloxone; Narcotics; Oxidopamine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rotation | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Body temperature response profiles for selective mu, delta and kappa opioid agonists in restrained and unrestrained rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical | 1988 |
The kappa-opioid receptor from human placenta: hydrodynamic characteristics and evidence for its association with a G protein.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Binding, Competitive; Centrifugation, Density Gradient; Chromatography, Gel; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Microvilli; Oligopeptides; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride | 1988 |
Selective tolerance at mu and kappa opioid receptors modulating norepinephrine release in guinea pig cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guinea Pigs; Male; Morphine; Norepinephrine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Opioid mu and kappa receptors on axons of cholinergic excitatory motor neurons supplying the circular muscle of guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Axons; Carbachol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Motor Neurons; Muscle, Smooth; Myenteric Plexus; Narcotics; Parasympathetic Nervous System; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1988 |
Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Binding Sites; Brain; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Levallorphan; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1985 |
Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at mu- and kappa-opioid receptor sites in rabbit and guinea-pig cerebellum membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1985 |
Antinociceptive profiles of opioid peptide agonists in a rat tooth pulp stimulation procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dental Pulp; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Pain; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains | 1985 |
Differential effect of stimulation strength in mouse vas deferens on inhibition of neuroeffector transmission by receptor type selective opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cyclazocine; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Morphine Derivatives; Muscle, Smooth; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Synaptic Transmission | 1986 |
Different effects of dynorphin A on in vitro guinea pig hippocampal CA3 pyramidal cells with various degrees of paired-pulse facilitation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 1986 |
Centrally-administered opioid selective agonists inhibit drinking in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Drinking Behavior; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Antagonism of mu-opioid receptor-mediated inhibitions of nociceptive neurones by U50488H and dynorphin A1-13 in the rat dorsal horn.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Naloxone; Neural Inhibition; Nociceptors; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1987 |
Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Arthritis; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Morphine; Naloxone; Nociceptors; Pain; Peripheral Nerves; Pyrrolidines | 1987 |
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Purification of a kappa-opioid receptor subtype from frog brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Chromatography, Gel; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Membranes; Molecular Weight; Naloxone; Peptide Fragments; Pyrrolidines; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa; Solubility | 1987 |
Mu-, delta-, kappa- and epsilon-opioid receptor modulation of the hypothalamic-pituitary-adrenocortical (HPA) axis: subchronic tolerance studies of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Functional opioid receptor sites in human placentas.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gonadotropin-Releasing Hormone; Humans; Kinetics; Placenta; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thyrotropin-Releasing Hormone | 1988 |
Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydrazines; Morphine; Peptide Fragments; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin | 1987 |
CNS blockade of acoustic stress-induced gastric motor inhibition by kappa-opiate agonists in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Adrenocorticotropic Hormone; Analgesics; Animals; Cyclazocine; Dogs; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gastrointestinal Motility; Hydrocortisone; Pyrrolidines; Stress, Physiological | 1988 |
Antinociceptive action of intracerebroventricularly administered dynorphin and other opioid peptides in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Cold Temperature; Drug Interactions; Dynorphins; Enkephalins; Injections, Intraventricular; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1988 |
Orally administered kappa but not mu opiate agonists enhance gastric emptying of a solid canned food meal in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Diuretics; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Beta-endorphin-(1-27) antagonizes beta-endorphin- but not morphine-, D-Pen2-D-Pen5-enkephalin- and U50, 488H-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Peptide Fragments; Pyrrolidines; Reaction Time | 1988 |
TENA, a selective kappa opioid receptor antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
Opposing effects of oxytocin and of a mu-receptor agonistic opioid peptide on the same class of non-pyramidal neurones in rat hippocampus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Interneurons; Male; Oxytocin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Central effects of mu, delta, and kappa receptor agonists in hemorrhagic shock.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blood Pressure; Consciousness; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Hypothalamus, Anterior; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Shock, Hemorrhagic | 1985 |
Selective cardiovascular and neuroendocrine effects of a kappa-opioid agonist in the nucleus tractus solitarii of rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arginine Vasopressin; Benzomorphans; Enkephalin, Leucine; Hemodynamics; Male; Medulla Oblongata; Oligopeptides; Phenoxybenzamine; Pyrrolidines; Rats; Rats, Brattleboro; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 1985 |
Mu and kappa opiate receptor involvement in agonistic behaviour in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aggression; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Male; Mice; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Social Behavior; Time Factors | 1985 |
Irreversible selective blockade of kappa-opioid receptors in the guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Autoradiographic localization in rat brain of kappa opiate binding sites labelled by [3H]bremazocine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphinans; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Effects of specific activation of mu-, delta- and kappa-opioid receptors on the secretion of luteinizing hormone and prolactin in the ovariectomized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Luteinizing Hormone; Ovariectomy; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electric Stimulation; Electrodes; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphinans; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
The specific opioid kappa-agonist U-50,488H inhibits low Km GTPase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cerebellum; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; Guinea Pigs; In Vitro Techniques; Narcotic Antagonists; Phosphoric Monoester Hydrolases; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Analgesia produced by centrally administered DAGO, DPDPE and U50488H in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Formaldehyde; Injections, Intraventricular; Male; Nociceptors; Pyrrolidines; Rats | 1988 |
A monoclonal antibody that inhibits opioid binding to rat brain membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antibodies, Monoclonal; Brain; Cattle; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme-Linked Immunosorbent Assay; Membranes; Narcotics; Pyrrolidines; Rats | 1988 |
Opposite effects of kappa-opioid agonists on gastric emptying of liquids and solids in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Injections, Intravenous; Morphinans; Morphine; Naloxone; Pyrrolidines | 1988 |
Sex and day-night differences in opiate-induced responses of insular wild deer mice, Peromyscus maniculatus triangularis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Circadian Rhythm; Enkephalin, Leucine; Feeding Behavior; Female; Male; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Pain; Peromyscus; Pyrrolidines; Sex Characteristics | 1987 |
Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Digestive System Physiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Narcotics; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1984 |
Opioid control of the ruminant stomach motility: functional importance of mu, kappa and delta receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep; Stomach | 1984 |
Radioligands for probing opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1984 |
Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Cyclazocine; Dynorphins; Electric Conductivity; Enkephalins; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Affinities of some common opioid analgesics towards four binding sites in mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding Sites; Brain; Codeine; Cyclazocine; Dextropropoxyphene; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Methionine; Ethylketocyclazocine; In Vitro Techniques; Membranes; Methadone; Mice; Models, Biological; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Studies on the pharmacology of central opioid-induced increases in plasma catecholamines in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Analgesics; Animals; Catecholamines; Dioxanes; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; Injections, Intraventricular; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1984 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
Transgenic superoxide dismutase mice differ in opioid-induced analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Autoradiography; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Mice; Mice, Transgenic; Morphine; Nociceptors; Pyrrolidines; Superoxide Dismutase | 1995 |
Opioids inhibit the induction of nitric oxide synthase in J774 macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Induction; Lipopolysaccharides; Macrophages; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Pyrrolidines; Receptors, Opioid | 1995 |
Differential effects of 3-isobutyl-1-methylxanthine injected intrathecally or intracerebroventricularly on antinociception induced by opioids administered intracerebroventricularly in the mouse.
Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3',5'-Cyclic-AMP Phosphodiesterases; Analgesia; Animals; beta-Endorphin; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Spinal Cord | 1995 |
Regional haemodynamic effects of mu-, delta-, and kappa-opioid agonists microinjected into the hypothalamic paraventricular nuclei of conscious, unrestrained rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antihypertensive Agents; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hemodynamics; Hindlimb; Laser-Doppler Flowmetry; Male; Mesenteric Arteries; Microinjections; Paraventricular Hypothalamic Nucleus; Pyrrolidines; Rats; Rats, Inbred WKY; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Renal Artery; Tachycardia; Vasoconstriction; Vasodilation | 1995 |
Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Amino Acid Sequence; Cell Line; Colforsin; Culture Media, Conditioned; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Receptors, Opioid, delta | 1995 |
Opioids modify the release of LH at the pituitary level: in vitro studies with entire rat pituitaries.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Naloxone; Narcotics; Oligopeptides; Organ Culture Techniques; Pituitary Gland; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Modulation of free intracellular calcium levels [(Ca++)i] in brain and spinal cord of morphine-tolerant rats and mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Calcium; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fura-2; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Subcellular Fractions; Synaptosomes | 1995 |
Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Glycosylation; Molecular Sequence Data; Naltrexone; Oligopeptides; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sodium; Tritium | 1995 |
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
Contrasting actions of intrathecal U50,488H, morphine, or [D-Pen2, D-Pen5] enkephalin or intravenous U50,488H on the visceromotor response to colorectal distension in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum | 1995 |
Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Colon; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum | 1995 |
Peripheral opioid modulation of pain and inflammation in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Inflammation; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Narcotics; Pain; Pyrrolidines; Rats; Receptors, Opioid | 1995 |
Delta, mu and kappa opioid receptor agonists inhibit dopamine overflow in rat neostriatal slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Neostriatum; Nomifensine; Oligopeptides; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Opioid agonists modulate release of neurotransmitters in bovine trachealis muscle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Cattle; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Muscle Contraction; Neurotransmitter Agents; Pyrrolidines; Receptors, Opioid; Trachea | 1995 |
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella | 1993 |
Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Axonal Transport; beta-Endorphin; Biological Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Ligation; Male; Naloxone; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve | 1993 |
Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Analgesics; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homovanillic Acid; Hydroxyindoleacetic Acid; Limbic System; Male; Microinjections; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali | 1993 |
Opioid inhibition of rapid eye movement sleep by a specific mu receptor agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cats; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Neprilysin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Reticular Formation; Sleep, REM; Wakefulness | 1995 |
Differential cross-tolerance between analgesia produced by alpha 2-adrenoceptor agonists and receptor subtype selective opioid treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics; Animals; Binding Sites; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Xylazine | 1995 |
Action of opioid peptides on the rat adrenal cortex: stimulation of steroid secretion through a specific mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Cortex; Aldosterone; Analgesics; Animals; beta-Endorphin; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Opioid Peptides; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Ventral tegmental area opioid mechanisms and modulation of ingestive behavior.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Male; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Ventral Tegmental Area | 1995 |
Electrophysiological effects of opioid receptor selective agonists on guinea-pig papillary muscle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Absence; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Naltrexone; Pyrroles; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1995 |
Role of nitric oxide/cyclic GMP in i.c.v. administered beta-endorphin- and (+)-cis-dioxolane-induced antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Arginine; beta-Endorphin; Cyclic GMP; Dioxolanes; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemoglobins; Injections, Intraventricular; Male; Methylene Blue; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Nitric Oxide; Nitroarginine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1994 |
Differential antagonism by MK-801 against antinociception induced by opioid receptor agonists administered supraspinally in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 1994 |
Electrophysiological effects of selective opioid agonists on spontaneous and evoked neuronal activity in the dentate gyrus of the hippocampus in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Hippocampus; Interneurons; Male; Morphine; Naloxone; Neurons; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Cross-tolerance between kappa and mu opioid agonists in the guinea pig ileum myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Myenteric Plexus; Perfusion; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Anesthesia, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Halothane; Heart Rate; Hot Temperature; Injections, Spinal; Male; Morphine; Nalbuphine; Nociceptors; Pain Threshold; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Reflex; Thiophenes | 1995 |
Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medulla.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Medulla Oblongata; Molecular Sequence Data; Oligopeptides; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Functional couplings of the delta- and the kappa-opioid receptors with the G-protein-activated K+ channel.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Base Sequence; Cloning, Molecular; Codon; DNA Primers; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kinetics; Membrane Potentials; Mice; Molecular Sequence Data; Naloxone; Oocytes; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Xenopus laevis | 1995 |
Dexamethasone-induced selective inhibition of the central mu opioid receptor: functional in vivo and in vitro evidence in rodents.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dexamethasone; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Mice; Morphine; Oligopeptides; Pain Measurement; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu | 1994 |
Electrophysiological demonstration of mu, delta and kappa opioid receptors in the ventral pallidum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Amino Acid Sequence; Animals; Brain Mapping; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Globus Pallidus; Iontophoresis; Male; Molecular Sequence Data; Morphine; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Barium Compounds; Cadmium; Carbachol; Chlorides; Computer Simulation; Dynorphins; Electrophysiology; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Models, Neurological; Naloxone; Narcotics; Neurons; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Dynorphin gene expression and release in the myocardial cell.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Cells, Cultured; Cytosol; Dynorphins; Enkephalins; Gene Expression; Heart; Heart Ventricles; Male; Myocardium; Potassium Chloride; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; RNA, Messenger | 1994 |
Kappa-selective agonists decrease postsynaptic potentials and calcium components of action potentials in the supraoptic nucleus of rat hypothalamus in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics; Animals; Benzomorphans; Calcium; Cesium; Dynorphins; Electric Stimulation; Electrophysiology; Enkephalins; Humans; In Vitro Techniques; Male; Membrane Potentials; Narcotic Antagonists; Neurosecretory Systems; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Supraoptic Nucleus; Synapses; Tetraethylammonium Compounds | 1994 |
Behavioral effects of systemically administered mu and kappa opioid agonists in the squirrel monkey: peptides versus alkaloids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alkaloids; Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intramuscular; Male; Morphine; Peptide Fragments; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule; Saimiri | 1994 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Antisense oligodeoxynucleotide to a delta-opioid receptor selectively blocks the spinal antinociception induced by delta-, but not mu- or kappa-opioid receptor agonists in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger | 1994 |
The kappa agonist fedotozine modulates colonic distention-induced inhibition of gastric motility and emptying in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzyl Compounds; Bretylium Compounds; Catheterization; Colon; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Emptying; Gastrointestinal Motility; Granisetron; Hexamethonium; Male; Naltrexone; Narcotic Antagonists; Propylamines; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Stomach | 1994 |
Effects of mu-, delta- and kappa-agonists on isolated right atria of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Propranolol; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Mu and delta opioid receptors mediate opposite modulations by morphine of the spinal release of cholecystokinin-like material.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cholecystokinin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1994 |
In vivo treatment with mu and delta, but not kappa-selective opioid agonists reduces [3H]spiperone binding to the guinea-pig striatum: autoradiographic evidence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Brain; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Male; Morphine; Organ Specificity; Pyrrolidines; Receptors, Dopamine D2; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiperone; Tritium | 1994 |
Selective antagonism of opioid analgesia by a sigma system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Haloperidol; Male; Mice; Morphine; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, sigma; Species Specificity | 1994 |
Cross-tolerance between mu- and kappa-opioid agonists in the guinea pig ileum myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Myenteric Plexus; Narcotics; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil | 1994 |
Comparative study of the effects of mu, delta and kappa opioid agonists on 3H-dopamine uptake in rat striatum and nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Synaptosomes | 1994 |
U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Male; Morphine; Morphine Dependence; Nociceptors; Pain; Pyrrolidines; Receptors, Opioid, kappa | 1994 |
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 1994 |
Restraint changes pentobarbital-induced sleeping time in rats: evidence that arousal is modulated by brain corticotropin-releasing hormone and opioid in stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arousal; Brain; Cerebral Ventricles; Corticotropin-Releasing Hormone; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Pentobarbital; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Restraint, Physical; Sleep; Stress, Psychological | 1994 |
Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cerebral Ventricles; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression; GTP-Binding Proteins; In Situ Hybridization; Infusions, Parenteral; Male; Naltrexone; Narcotics; Oligonucleotide Probes; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Endogenous opioid regulation of oxytocin secretion through pregnancy in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Pregnancy; Pregnancy, Animal; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Vasopressins | 1993 |
Opioid actions on neurons of rat lateral amygdala in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Amino Acids; Amygdala; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; GABA-A Receptor Antagonists; In Vitro Techniques; Molecular Sequence Data; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pyrrolidines; Rats; Somatostatin; Synapses | 1993 |
Cloning and expression of a cDNA for the rat kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Base Sequence; Cells, Cultured; Cloning, Molecular; DNA; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sequence Homology, Amino Acid | 1993 |
Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Benzomorphans; beta-Endorphin; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Pain Measurement; Pyrrolidines; Spinal Cord; Time Factors | 1993 |
Regulatory role of enteric kappa opioid receptors in human colonic motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Colon, Sigmoid; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Gastrointestinal Motility; Humans; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Delta-1 opioid agonist acutely increases hypoxic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Benzylidene Compounds; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypoxia; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid, delta | 1994 |
Inhibition of cholinergic transmission by opiates in ileal myenteric plexus is mediated by kappa receptor. Involvement of regulatory inhibitory G protein and calcium N-channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Calcium Channels; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Ileum; Male; Myenteric Plexus; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Veratridine; Virulence Factors, Bordetella | 1994 |
Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1994 |
The antinociceptive and motivational effects of intranigral injection of opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Morphine; Morphine Derivatives; Motivation; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reward; Stereotaxic Techniques; Substantia Nigra; Time Factors | 1993 |
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Fura-2; Glioma; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Microscopy, Fluorescence; Naloxone; Narcotics; Neuroblastoma; Pyrrolidines; Rats; Tumor Cells, Cultured | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Blockade of U50,488H analgesia by antisense oligodeoxynucleotides to a kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Binding Sites; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Injections, Spinal; Molecular Sequence Data; Oligonucleotides, Antisense; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Opioid antagonist diprenorphine microinjected into parabrachial nucleus selectively inhibits vasopressin response to hypovolemic stimuli in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Disease; Animals; Antihypertensive Agents; Brain; Cerebral Ventricles; Diprenorphine; Enkephalin, Leucine; Hemodynamics; Male; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Shock; Solitary Nucleus; Stimulation, Chemical; Vasopressins | 1993 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |
Effect of diabetes on the antinociceptive effect of beta-endorphin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Reference Values | 1993 |
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Analgesics; Animals; Binding, Competitive; Bombesin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Naltrexone; Oximes; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa | 1993 |
The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration | 1993 |
Effect of opioid receptor subtype-selective agonists on purinergic and adrenergic components of neurogenic contractions of mouse vas deferens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Receptors, Adrenergic; Receptors, Opioid; Receptors, Purinergic; Sympathetic Nervous System; Vas Deferens | 1993 |
Evidence for mu-, delta-, and kappa-opioid receptors in a human neuroblastoma cell line.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Binding, Competitive; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Tritium; Tumor Cells, Cultured | 1993 |
Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord | 1993 |
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1993 |
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1993 |
Feeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Male; Pyrrolidines; Rats; Receptors, Opioid | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Antisense oligodeoxynucleotides to the kappa-1 receptor block the antinociceptive effects of delta 9-THC in the spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligonucleotides, Antisense; Pain; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, kappa; Spinal Cord | 1995 |
The effect of intrathecal opioid-receptor agonists on visceral noxious stimulation in rabbits.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Catheterization; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Spinal; Morphine; Motor Activity; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Viscera | 1996 |
Effects of microinjections of mu and kappa receptor agonists into the dorsal periaqueductal gray of rats submitted to the plus maze test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Maze Learning; Microinjections; Narcotics; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Involvement of different subtypes of cholecystokinin receptors in opioid antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; beta-Endorphin; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Meglumine; Mice; Mice, Inbred ICR; Morphine; Narcotics; Pain Measurement; Proglumide; Pyrrolidines; Receptors, Cholecystokinin; Sincalide | 1995 |
Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Catheterization; Colon; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rectum | 1995 |
The peristaltic reflex in the rat ileum: evidence for functional mu- and delta-opiate receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidiarrheals; Diphenoxylate; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ileum; Linear Models; Loperamide; Morphine; Peristalsis; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Peripheral Nerve Injuries; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1995 |
Dexamethasone selective inhibition of acute opioid physical dependence in isolated tissues.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mifepristone; Muscle Contraction; Naloxone; Opioid-Related Disorders; Pyrrolidines; Rabbits; Substance Withdrawal Syndrome | 1996 |
Regulation of human B lymphocyte activation by opioid peptide hormones. Inhibition of IgG production by opioid receptor class (mu-, kappa-, and delta-) selective agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Analgesics; B-Lymphocytes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Humans; Immunoglobulin G; Interleukin-6; Lymphocyte Activation; Male; Opioid Peptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Staphylococcus aureus | 1996 |
Effect of the intraperitoneal administration of salmon-calcitonin on the "in vitro" actions of opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1995 |
Effects of central administration of highly selective opioid mu-, delta- and kappa-receptor agonists on plasma luteinizing hormone (LH), prolactin, and the estrogen-induced LH surge in ovariectomized ewes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Estradiol; Female; Injections, Intraventricular; Luteinizing Hormone; Narcotics; Oils; Ovariectomy; Prolactin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep | 1996 |
mu-Opioid agonists stimulate growth hormone secretion in immature rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Growth Hormone; Male; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors | 1996 |
Modulation of kappa-opioid receptor mediated tolerance in the guinea-pig ileum by chronic co-administration of dihydropyridines.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Nimodipine; Pyrrolidines; Receptors, Opioid, kappa | 1996 |
Alteration of calcitonin gene related peptide and its receptor binding sites during the development of tolerance to mu and delta opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Calcitonin Gene-Related Peptide; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunohistochemistry; Male; Morphine; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1995 |
Role of central mu, delta-1, and kappa-1 opioid receptors in opioid-induced muscle rigidity in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Muscle Rigidity; Narcotics; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Pretreatment with pertussis toxin differentially modulates morphine- and beta-endorphin-induced antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Opioid; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Pertussis Toxin; Pyrrolidines; Receptors, Serotonin; Virulence Factors, Bordetella | 1996 |
Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Nociceptin; Opioid Peptides; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Induction of Fos-like immunoreactivity by opioids in guinea-pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Telencephalon | 1996 |
Effect of mu, delta and kappa opioid receptor agonists on a reactive oxygen species mediated model of skin inflammation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dermatitis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Male; Pyrrolidines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Opioid; Skin | 1996 |
Distribution and changes in mu- and kappa-opiate receptors during the midlife neurodevelopmental period of Coho salmon, Oncorhynchus kisutch.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Oncorhynchus kisutch; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thyroxine; Tritium | 1996 |
Intrathecally injected nicotine enhances the antinociception induced by morphine but not beta-endorphin, D-Pen2,5-enkephalin and U50,488H administered intrathecally in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord | 1996 |
Nicotine enhances morphine- and beta-endorphin-induced antinociception at the supraspinal level in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nociceptors; Pain; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Evidence for multiple opioid receptors in the human posterior pituitary.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Benzeneacetamides; Binding Sites; Binding, Competitive; Cadaver; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Male; Middle Aged; Narcotics; Oligopeptides; Pituitary Gland, Posterior; Pyrrolidines; Receptors, Opioid; Tissue Distribution | 1996 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Brain Stem; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Solitary Nucleus; Stomach | 1996 |
Effects of morphine-3-glucuronide on the antinociceptive activity of peptide and nonpeptide opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Morphine Derivatives; Nociceptors; Oligopeptides; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Delta-1 opioid receptor-mediated antinociceptive properties of a nonpeptidic delta opioid receptor agonist, (-)TAN-67, in the mouse spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Pyrrolidines; Quinolines; Reaction Time; Receptors, Opioid, delta; Spinal Cord | 1997 |
Pharmacological characterization of buprenorphine, a mixed agonist-antagonist with kappa 3 analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Buprenorphine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sensitivity and Specificity | 1997 |
Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster. III. Autocrine stimulation of prodynorphin gene expression by dynorphin B.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cardiomyopathy, Hypertrophic; Cell Compartmentation; Cell Nucleus; Cricetinae; Cytosol; Dynorphins; Endorphins; Enkephalins; Enzyme Inhibitors; Gene Expression; Mesocricetus; Myocardium; Protein Kinase C; Protein Precursors; Pyrrolidines; Receptors, Opioid, kappa; Ryanodine; Sarcoplasmic Reticulum | 1997 |
The effect of pretreatment with a delta 2-opioid receptor antisense oligodeoxynucleotide on the recovery from acute antinociceptive tolerance to delta 2-opioid receptor agonist in the mouse spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Oligopeptides; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; RNA, Antisense | 1997 |
Differential modulation by muscimol and baclofen on antinociception induced by morphine, beta-endorphin, D-Pen2,5-enkephalin and U50,488H administered intracerebroventricularly in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analysis of Variance; Animals; Baclofen; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Mice; Morphine; Muscimol; Pyrrolidines; Receptors, GABA; Receptors, Opioid, kappa | 1995 |
Delta and kappa opioid receptor subtypes and ingestion: antagonist and glucoprivic effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Ventricles; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperphagia; Infusions, Parenteral; Male; Naloxone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regression Analysis | 1997 |
Opioid modulation of the fetal hypothalamic-pituitary-adrenal axis: the role of receptor subtypes and route of administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenocorticotropic Hormone; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hydrocortisone; Hypothalamo-Hypophyseal System; Injections, Intravenous; Injections, Intraventricular; Pituitary-Adrenal System; Pregnancy; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep | 1997 |
Effects of ibogaine and noribogaine on the antinociceptive action of mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; Male; Mice; Morphine; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Effects of ibogaine on the development of tolerance to antinociceptive action of mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; Male; Mice; Morphine; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Differential influence of D1 and D2 dopamine receptors on acute opiate withdrawal in guinea-pig isolated ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Apomorphine; Dopamine Agents; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Haloperidol; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Pyrrolidines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1997 |
Differential effects of mu-, delta- and kappa-opioid receptor agonists on the discriminative stimulus properties of cocaine in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Narcotics; Pyrrolidines; Quinolines; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders | 1997 |
Intracisternal injection of opioids induces itch-associated response through mu-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cisterna Magna; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Pruritus; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Inhibition of airway constriction by opioids is different down the isolated bovine airway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Bronchi; Bronchoconstriction; Cattle; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Narcotics; Pyrrolidines; Receptors, Opioid; Trachea | 1997 |
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Animals; Binding Sites; Cell Membrane; CHO Cells; Cholera Toxin; Cloning, Molecular; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Magnesium; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Proteins; Sodium; Sulfur Radioisotopes; Virulence Factors, Bordetella | 1997 |
Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord | 1997 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Effect of 7-nitroindazole on tolerance to morphine, U-50,488H and [D-Pen2, D-Pen5] enkephalin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Indazoles; Male; Mice; Morphine; Nitric Oxide Synthase; Nociceptors; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1997 |
Mobilization of Ca2+ from intracellular stores in transfected neuro2a cells by activation of multiple opioid receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Mice; Receptors, Opioid; Transfection | 1997 |
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon | 1997 |
The competitive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist LY293558 attenuates and reverses analgesic tolerance to morphine but not to delta or kappa opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoquinolines; Male; Mice; Morphine; Receptors, AMPA; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tetrazoles | 1997 |
Effect of chronic administration of morphine, U-50, 488H and [D-Pen2, D-Pen5]enkephalin on the concentration of cGMP in brain regions and spinal cord of the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Cyclic GMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Nitric Oxide; Nitric Oxide Synthase; Receptors, Opioid; Spinal Cord; Up-Regulation | 1997 |
Electroconvulsive shock blocks the opioid-mediated inhibition of dopamine release in rat striatal slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Dopamine; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Neural Inhibition; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Lack of morphine and enkephalin tolerance in 129/SvEv mice: evidence for a NMDA receptor defect.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Arginine; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Mice, Inbred Strains; Morphine; Nitric Oxide; Nitroprusside; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1998 |
Actions of opioids on respiratory activity via activation of brainstem mu-, delta- and kappa-receptors; an in vitro study.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Medulla Oblongata; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiratory System | 1997 |
Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Enkephalins; Female; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Pain; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Viscera | 1998 |
Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Animals; Antibody Specificity; Astrocytes; Brain Chemistry; Calcium; Cell Cycle; Cell Division; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Flow Cytometry; Hippocampus; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Interactions of cocaine with morphine, U-50,488H and [D-Pen2, D-Pen5]enkaphalin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Male; Mice; Morphine; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Opioids disrupt Ca2+ homeostasis and induce carbonyl oxyradical production in mouse astrocytes in vitro: transient increases and adaptation to sustained exposure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Astrocytes; Calcium; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homeostasis; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Narcotics; Oxidative Stress; Reactive Oxygen Species; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Treatment of chronic allodynia in spinally injured rats: effects of intrathecal selective opioid receptor agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Chronic Disease; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypesthesia; Injections, Spinal; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord Injuries | 1998 |
mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Transit; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Morphine; Receptors, Opioid, mu | 1998 |
The regulating manner of opioid receptors on distinct types of calcium channels in hamster submandibular ganglion cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium Channels; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Parasympathetic; Male; Naloxone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Submandibular Gland; Synaptic Transmission | 1998 |
Differential regulation of the cloned kappa and mu opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cell Line; Cloning, Molecular; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Hormone Antagonists; Ion Channel Gating; Mice; Naloxone; Narcotic Antagonists; Peptides, Cyclic; Pituitary Gland; Potassium; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Somatostatin | 1998 |
Baroreflex-mediated bradycardia is blunted by intravenous mu- but not kappa-opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Baroreflex; Blood Pressure; Bradycardia; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Heart Rate; Propranolol; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep | 1998 |
Activation of opioid receptors inhibits neuronal-like calcium channels, distal steps of secretion, and cell proliferation in human small cell lung carcinoma cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Bucladesine; Calcium Channels; Carcinoma, Small Cell; Cell Division; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Lung Neoplasms; Naloxone; Neurons; Receptors, Opioid, delta; Serotonin; Thapsigargin; Time Factors; Tumor Cells, Cultured | 1998 |
Age- and temperature-dependent effects of opioids on medulla oblongata respiratory activity: an in vitro study in newborn rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Medulla Oblongata; Morphine; Rats; Rats, Sprague-Dawley; Respiration; Spinal Cord; Temperature | 1998 |
Involvement of nitric oxide in peripheral antinociception mediated by kappa- and delta-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzoates; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Formaldehyde; Imidazoles; Male; Nitric Oxide; Nitro Compounds; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1998 |
Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Naloxone; Receptors, Cell Surface; Receptors, Opioid; Transfection | 1998 |
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzofurans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oligopeptides; Pain Measurement; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Signal Transduction; Vas Deferens | 1998 |
Modulation of the induction of ornithine decarboxylase by some opioid receptor agonists in immune cells and cardiomyocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; B-Lymphocytes; Cells, Cultured; Enkephalin, Leucine; Enzyme Induction; Immune System; Ligands; Male; Myocardium; Organ Specificity; Ornithine Decarboxylase; Rats; Rats, Wistar; Receptors, Opioid; RNA, Messenger; T-Lymphocytes | 1998 |
Relationship between inhibitory effect of endogenous opioid via mu-receptors and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
Involvement of mu-receptor in endogenous opioid peptide-mediated inhibition of acetylcholine release from the rat stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; beta-Endorphin; Electric Stimulation; Enkephalins; Gastric Mucosa; In Vitro Techniques; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid, mu; Stomach; Vagus Nerve | 1998 |
[Inhibitory effects of three opioid receptor agonists on synaptic transmission].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 1996 |
The role of nitric oxide in the development of opioid withdrawal induced by naloxone after acute treatment with mu- and kappa-opioid receptor agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Narcotic Antagonists; Narcotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Vasodilator Agents | 1998 |
Stimulation of phospholipase C by the cloned mu, delta and kappa opioid receptors via chimeric G alpha(q) mutants.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cloning, Molecular; COS Cells; DNA, Complementary; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Type C Phospholipases | 1999 |
Characterization of mechanical withdrawal responses and effects of mu-, delta- and kappa-opioid agonists in normal and mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Physical Stimulation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Substance Withdrawal Syndrome | 1999 |
Effect of salmon-calcitonin on the analgesic effect of selective mu, delta and kappa opioid agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membranes; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Morphine; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Tritium | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Brain; Cardiovascular Agents; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Membranes; Middle Aged; Myocardium; Nociceptin; Oligopeptides; Opioid Peptides; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes | 1999 |
Augmenting effect of opioids on nitrite production by stimulated murine macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitrites; Opioid Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ion Channel Gating; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1999 |
Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Solitary Nucleus; Stomach; Vagus Nerve | 1999 |
Enkephalin regulates acute D2 dopamine receptor antagonist-induced immediate-early gene expression in striatal neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Corpus Striatum; DNA Primers; DNA-Binding Proteins; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Early Growth Response Protein 1; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; In Situ Hybridization; Male; Molecular Sequence Data; Naloxone; Neurons; Oligopeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Salicylamides; Transcription Factors; Transcriptional Activation | 1999 |
Antagonistic effect of orphanin FQ on opioid analgesia in rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analgesics, Opioid; Animals; Enkephalin, Leucine; Fentanyl; Injections, Intraventricular; Injections, Spinal; Male; Nociceptin; Opioid Peptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
Peptide transport system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Capillaries; Carrier Proteins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Iodine Radioisotopes; Male; Mice; Mice, Inbred ICR; MSH Release-Inhibiting Hormone; Receptors, Opioid; Thyrotropin-Releasing Hormone; Tyrosine | 1999 |
Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Calcium Channel Blockers; Calcium Channels, N-Type; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Humans; Neuroblastoma; omega-Conotoxins; Pertussis Toxin; Potassium Cyanide; Receptors, Opioid, kappa; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dopamine; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exploratory Behavior; Foot; Habituation, Psychophysiologic; Hot Temperature; Mice; Mice, Knockout; Models, Neurological; Morphine; Motor Activity; Nociceptors; Oligopeptides; Pain; Pain Threshold; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Stress, Physiological; Swimming; Tail; Viscera | 2000 |
Cornea-responsive medullary dorsal horn neurons: modulation by local opioids and projections to thalamus and brain stem.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Blinking; Carbon Dioxide; Cornea; Efferent Pathways; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Facial Nerve; Male; Medulla Oblongata; Microinjections; Morphine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Stimulation, Chemical; Thalamus; Trigeminal Caudal Nucleus | 2000 |
Effect of centrally administered opioid receptor agonists on CSF and plasma oxytocin concentrations in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Male; Morphine; Oxytocin; Random Allocation; Receptors, Opioid | 2001 |
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus | 2002 |
Effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Dynorphins; Enkephalins; Female; Luteinizing Hormone; Naltrexone; Ovulation; Peptide Fragments; Proestrus; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
The regulation of steroidogenesis by opioid peptides in porcine theca cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; Cells, Cultured; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Estradiol; Female; Opioid Peptides; Progesterone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Steroids; Swine; Testosterone; Theca Cells | 2003 |
The influence of opioid peptides on steroidogenesis in porcine granulosa cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Granulosa Cells; Luteinizing Hormone; Opioid Peptides; Ovarian Follicle; Swine | 2004 |
Alpha 7-type nicotinic acetylcholine receptor and prodynorphin mRNA expression after administration of (-)-nicotine and U-50,488H in beta-amyloid peptide (25-35)-treated mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Enkephalins; Gene Expression Regulation; Male; Mice; Nicotine; Peptide Fragments; Protein Precursors; Receptors, Nicotinic; RNA, Messenger | 2004 |
Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; beta-Endorphin; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalins; Lithium Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Protein Precursors; Reaction Time | 2005 |
Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Drug Interactions; Enkephalins; Enzyme Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Time Factors | 2006 |
Kappa opioid control of seizures produced by a virus in an animal model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blotting, Northern; Borna Disease; Cell Survival; Disease Models, Animal; Dynorphins; Electroencephalography; Encephalitis, Viral; Enkephalins; Hippocampus; Male; Naloxone; Narcotic Antagonists; Neurons; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa; Seizures | 2006 |
Reversion of levodopa-induced motor fluctuations by the A2A antagonist CSC is associated with an increase in striatal preprodynorphin mRNA expression in 6-OHDA-lesioned rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic Agents; Animals; Caffeine; Corpus Striatum; Dynorphins; Dyskinesias; Enkephalins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger | 2006 |
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cell Line; Cell Nucleus; DNA; Dynorphins; Electrophoretic Mobility Shift Assay; Enkephalins; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Insulin-Secreting Cells; Islets of Langerhans; Kv Channel-Interacting Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Binding; Protein Precursors; Receptors, Opioid, kappa; Repressor Proteins | 2006 |
Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzamides; Cell Count; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Temporal Lobe; Guanidines; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Nerve Degeneration; Piperazines; Protein Precursors; Receptors, Opioid, kappa; Synaptic Transmission; Time Factors | 2007 |
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Conditioning, Operant; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Odorants; Phosphorylation; Protein Precursors; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Urocortins | 2008 |
Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Enkephalins; Extinction, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Precursors; Receptors, Opioid, kappa; Stress, Psychological; Swimming | 2008 |
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Brain Stem; Corticosterone; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Exploratory Behavior; Female; Guanidines; Hypothalamus; Male; Maze Learning; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Neuropeptide Y; Neuropeptides; Protein Precursors; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzamides; beta-Endorphin; Blood Pressure; Cricetinae; Cyclic AMP; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypertension; Hypertrophy, Left Ventricular; Myocardial Contraction; Myocardium; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Systole; Ventricular Remodeling | 2009 |
Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Enkephalins; Gene Expression Regulation; Immobility Response, Tonic; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, kappa; Recognition, Psychology; Stress, Psychological; Swimming; Time Factors | 2009 |
Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Area Under Curve; Blotting, Western; Dopamine; Enkephalins; Gene Expression; Genes, fos; Mice; Mice, Knockout; Microdialysis; Motor Activity; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Substance Withdrawal Syndrome | 2009 |
Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Conditioning, Psychological; Enkephalins; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Precursors; Receptors, Opioid, kappa; Reward; Self Administration; Signal Transduction; Stress, Physiological | 2010 |
Agonist-induced internalization of κ-opioid receptors in noradrenergic neurons of the rat locus coeruleus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dopamine beta-Hydroxylase; Endocytosis; Enkephalins; Locus Coeruleus; Male; Microscopy, Immunoelectron; Neurons; Norepinephrine; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2010 |
Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; CA1 Region, Hippocampal; Enkephalins; Guanidines; Humans; Interneurons; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Neurodegenerative Diseases; Protein Precursors; Pyramidal Cells; Receptors, Opioid, kappa; Seizures | 2011 |
Dynorphins regulate the strength of social memory.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Enkephalins; Hippocampus; Memory; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, kappa; Recognition, Psychology; Social Behavior | 2014 |
In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Brain Edema; Brain Infarction; Brain Ischemia; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Ischemia; Motor Activity; Neurons; Neuroprotective Agents; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reperfusion Injury; Severity of Illness Index; Stroke | 2015 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |