enkephalin, leucine has been researched along with tyrosine in 90 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (45.56) | 18.7374 |
| 1990's | 32 (35.56) | 18.2507 |
| 2000's | 9 (10.00) | 29.6817 |
| 2010's | 7 (7.78) | 24.3611 |
| 2020's | 1 (1.11) | 2.80 |
| Authors | Studies |
|---|---|
| Schiller, PW | 1 |
| Cabassi, F; Guarneri, M; Tomatis, R; Zetta, L | 1 |
| Hughes, J; Kosterlitz, HW; McKnight, AT | 2 |
| Geiger, R | 1 |
| Fellion, E; Fournié-Zaluski, MC; Gacel, G; Lecomte, JM; Malfroy, B; Roques, BP; Schwartz, JC; Senault, B; Swerts, JP | 1 |
| Bleich, HE; Day, AR; Freer, RJ; Glasel, JA | 1 |
| Hughes, J; Kosterlitz, HW; McKnight, AT; Sosa, RP | 1 |
| Gilon, C; Muszkat, KA | 1 |
| Braun, LD; Cornford, EM; Crane, PD; Oldendorf, WH | 1 |
| Burks, TF; Davis, P; Fang, L; Hruby, VJ; Knapp, R; Kramer, TH; Landis, G; Russell, KC; Toth, G; Yamamura, HI | 1 |
| Anthony, E; Beardsley, PM; Chandrakumar, NS; Drury, B; Lopez, OT; Reichman, M; Savage, MA; Stapelfeld, A; Williamson, LN | 1 |
| Balasubramanian, AS; Ramamoorthy, S | 1 |
| Guerin, MC; Slaoui-Hasnaoui, A; Torreilles, J | 1 |
| Blarzino, C; Coccia, R; De Marco, C; Foppoli, C; Rosei, MA | 1 |
| Bruno, JA; Carvalho, KM; de Souza, AN | 1 |
| Ishikawa, K; Martinez, JL; Shibanoki, S; Weinberger, SB | 1 |
| Janak, PH; Martinez, JL | 1 |
| Khugaeva, VK | 1 |
| Kodama, H; Koshizaka, T; Kurono, M; Ogasawara, T; Shimohigashi, Y; Yagi, K | 1 |
| Gintzler, AR; Jacobson, AR; Sayre, LM | 1 |
| Livett, BG; Marley, PD; Wan, DC | 1 |
| Altiere, RJ; Crooks, PA; Gillespie, MN; Krechniak, JW; Olson, JW | 1 |
| Aoyagi, H; Costa, T; Izumiya, N; Kato, T; Lee, S; Mihara, H; Shimohigashi, Y | 1 |
| Portoghese, PS; Sugg, EE | 1 |
| Lentzen, H; Simon, R | 1 |
| Ishida, J; Kai, M; Ohkura, Y | 1 |
| Begley, DJ; Davson, H; Lipovac, MN; Rakić, L; Zloković, BV | 1 |
| D'Alagni, M; Roda, LG; Vita, F | 1 |
| Begley, DJ; Chain-Eliash, DG; Zlokovic, BV | 1 |
| Dhingra, MM; Gupta, G; Sarma, MH; Sarma, RH | 1 |
| Burbach, JP; de Wied, D; Gispen, WH; Loeber, JG; Verhoef, J; Witter, A | 1 |
| Schiller, PW; St-Hilaire, J | 1 |
| Coy, DH; Kastin, AJ | 1 |
| Denison, RC; Tsan, MF; Turkall, RM | 1 |
| Almquist, RG; Olsen, CM; Toll, L; Uyeno, ET | 1 |
| Izumiya, N; Shimohigashi, Y; Waki, M | 1 |
| Geary, LE; Kerchner, GA | 1 |
| Dik, J; van Amsterdam, JG; van Buuren, KJ; Wynne, HJ | 1 |
| Crooks, PA; Deeks, T; Waigh, RD | 1 |
| Caffrey, JL; Hodges, DH | 1 |
| Khugaeva, VK; Suchkov, VV; Titov, MI | 1 |
| Beaumont, A; Chabrier, PE; Hughes, J; Metters, KM; Unsworth, CD | 1 |
| Tan, L; Yu, PH | 2 |
| Jankowski, A; Siemion, IZ; Szewczuk, Z | 1 |
| Higashijima, T; Kobayashi, J; Miyazawa, T; Nagai, U | 1 |
| Gershon, S; Rotrosen, J; Siekierski, J; Tracer, H; Traficante, LJ | 1 |
| Baudet, J; Florentin, D; Garbay-Jaureguiberry, C; Roques, BP | 1 |
| Gershon, S; Rotrosen, J; Siekierski, J; Traficante, LJ | 1 |
| Scheinberg, DA; Wellner, D; Xu, Y | 1 |
| Callis, P; Gryczynski, I; Kierdaszuk, B; Lakowicz, JR; Malak, H | 1 |
| Chang, KJ; Chung, NN; Lee, PH; Nguyen, TM; Schiller, PW | 1 |
| Bolacchi, F; Bongiorno, L; Marini, M; Roda, LG; Urbani, A; Zona, C | 1 |
| Heyl, DL; Kroona, H; Lomize, AL; Ma, W; Mosberg, HI; Mousigian, C; Porreca, F; Sobczyk-Kojiro, K; Wang, C | 1 |
| Higuchi, H; Kuo, CH; Miki, N; Nakano, K; Osugi, T | 1 |
| Hochhaus, G; Larsimont, V; Prokai, L | 1 |
| Hasegawa, A; Nagamatsu, K; Tagawa, Y; Uchida, S | 1 |
| Gryczynski, I; Laczko, G; Lakowicz, JR; Wiczk, W | 1 |
| Nyasse, B; Ragnarsson, U | 1 |
| Iversen, L; Kragballe, K; Nissen, JB | 1 |
| Davis, P; Frycia, A; Hruby, VJ; Jaspers, H; Porreca, F; Toth, G; Tourwé, D; Van Binst, G; Verheyden, P; Verschueren, K | 1 |
| Banks, WA; Kastin, AJ; Maness, LM; Zadina, JE | 1 |
| Billington, D; MacKinnon, KL; Zuzel, KA | 1 |
| Blount, BC; Duncan, MW; Smythe, GA; Yi, D | 1 |
| Lin, M; Petersheim, M; Rinaldi, F; Shapiro, MJ | 1 |
| Bigelow, DJ; Krainev, AG; Williams, TD | 1 |
| Babst, R; Bongiorno, L; Marini, M; Marzano, M; Roda, LG; Spagnoli, G; Urbani, A | 1 |
| Ho, JC; Mosberg, HI; Sobczyk-Kojiro, K | 1 |
| Alfaro-Lopez, J; Burkey, TH; Hosohata, K; Hruby, VJ; Roeske, WR; Yamamura, HI | 1 |
| Banks, WA; Brown, TT; Kastin, AJ; Maresh, GA; Zadina, JE | 1 |
| Ambo, A; Ouchi, H; Sasaki, Y; Suto, T; Yamamoto, Y | 1 |
| Casis, L; de Gandarias, JM; Fernández, D; Gil, J; Irazusta Astiazaran, J; Varona, A | 1 |
| Andria, ML; Esposito, DH; Hiller, JM; Kramer, HK; Kushner, SA; Simon, EJ | 1 |
| Gawron, AJ; Lunte, SM | 1 |
| Dittert, L; Hussain, AA; Tashtoush, BM; Traboulsi, AA | 1 |
| Fontana, M; Mosca, L; Rosei, MA | 1 |
| Abdali, S; Bohr, H; Nielsen, OF; Refstrup, P | 1 |
| Ambo, A; Ariizumi, T; Igari, Y; Kohara, H; Niizuma, H; Sasaki, A; Sasaki, Y; Sato, K | 1 |
| Chung, NN; Lemieux, C; Schiller, PW; Weltrowska, G | 1 |
| Hwang, CC; Wang, YC; Wu, YC; Yeh, CC | 1 |
| Arsequell, G; Ballesteros, A; Barluenga, J; Valencia, G; Vilaró, M | 1 |
| Feng, Y; Ge, NH; Le, U; Sul, S; Tobias, DJ | 1 |
| Choi, YS; Pennington, CL; Wood, TD | 1 |
| Agalou, A; Georganta, EM; Georgoussi, Z | 1 |
| Blindauer, CA; Brayden, DJ; Haddleton, DM; Jones, MW; Mantovani, G; Ryan, SM; Wang, X | 1 |
| Hatch, DM; Kim, HY; Möller, MN; Porter, NA | 1 |
| Brodbelt, JS; Moore, KL; Robinson, MR | 1 |
| Cadel, S; Darmon, C; Foulon, T; Hervé, G; Pernier, J | 1 |
| Feng, Y; Ge, NH; Guo, C; Kumar, SKK; Udagawa, NS; Vinogradov, I | 1 |
3 review(s) available for enkephalin, leucine and tyrosine
| Article | Year |
|---|---|
Chemistry of neuropeptides regulation.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Analgesia; Animals; Anura; beta-Lipotropin; Brain Chemistry; Chemical Phenomena; Chemistry; Enkephalins; Gonadotropin-Releasing Hormone; Melanocyte-Stimulating Hormones; Peptides; Rats; Structure-Activity Relationship; Tyrosine | 1978 |
Structure-CNS activity studies with the enkephalins.
Topics: Analgesia; Animals; Brain; Endorphins; Enkephalins; Glycine; Methionine; Phenylalanine; Receptors, Opioid; Structure-Activity Relationship; Tyrosine | 1980 |
[Synthetic enkephalins and multiple opiate receptors].
Topics: Animals; Enkephalins; Guinea Pigs; Mice; Phenylalanine; Rats; Receptors, Opioid; Structure-Activity Relationship; Swine; Tyrosine | 1983 |
87 other study(ies) available for enkephalin, leucine and tyrosine
| Article | Year |
|---|---|
Conformational behavior of [Trp4, Met5]-enkephalin: comparison of fluorescence parameters at different Ph.
Topics: Amino Acid Sequence; Endorphins; Enkephalins; Hydrogen-Ion Concentration; Methionine; Protein Conformation; Spectrometry, Fluorescence; Tryptophan; Tyrosine | 1977 |
270-MHz 1H nuclear-magnetic-resonance study of Met-enkephalin in water. Conformational behaviour as a function of pH.
Topics: Amides; Endorphins; Enkephalins; Glycine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methionine; Molecular Conformation; Phenylalanine; Protons; Tyrosine; Water | 1979 |
Synthesis of enkephalins by guinea-pig striatum in vitro.
Topics: Animals; Corpus Striatum; Cycloheximide; Endorphins; Enkephalins; Guinea Pigs; Kinetics; Male; Protein Biosynthesis; Tyrosine | 1979 |
Conformation and biological activities of hexapeptides related to enkephalins: respective roles of the ammonium and hydroxyl groups of tyrosine.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Oligopeptides; Quaternary Ammonium Compounds; Structure-Activity Relationship; Tyrosine; Vas Deferens | 1979 |
NMR rotating frame relaxation studies of intramolecular motion in peptides. Tyrosine ring motion in methionine-enkephalin.
Topics: Endorphins; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Conformation; Protein Conformation; Tyrosine | 1979 |
Incorporation of labelled amino acids into the enkephalins.
Topics: Animals; Brain; Cycloheximide; Endorphins; Enkephalins; Leucine; Male; Methionine; Myenteric Plexus; Protein Precursors; Puromycin; Rats; Tyrosine | 1977 |
Chemically induced dynamic nuclear polarisation of tyrosyl proteins: leucine-enkephalin and di- and tri-tyrosine.
Topics: Dipeptides; Endorphins; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Conformation; Oligopeptides; Tyrosine | 1977 |
The incorporation of [3H]-tyrosine into the enkephalins of striatal slices of guinea-pig brain [proceedings].
Topics: Animals; Corpus Striatum; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Tyrosine | 1978 |
Blood-brain barrier restriction of peptides and the low uptake of enkephalins.
Topics: Animals; Blood-Brain Barrier; Carotid Arteries; Endorphins; Enkephalins; Oligopeptides; Peptides; Rats; Tyrosine | 1978 |
Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity.
Topics: Amino Acid Sequence; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Molecular Sequence Data; Protein Conformation; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Substrate Specificity; Tyrosine | 1992 |
Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Topics: Amides; Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glycine; Male; Mice; Molecular Sequence Data; Muscle Contraction; Neuroblastoma; Peptides, Cyclic; Phenylalanine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured; Tyrosine; Vas Deferens | 1992 |
Chemical modification of the monkey brain cytosolic aminopeptidase that cleaves enkephalin to its constituent amino acids. Evidence for essential tyrosine residue (residues).
Topics: Acetic Anhydrides; Amino Acids; Animals; Brain; Catalysis; Enkephalins; Haplorhini; Hydroxylamine; Hydroxylamines; Imidazoles; Leucyl Aminopeptidase; Photofluorography; Sulfhydryl Reagents; Tyrosine | 1992 |
Reciprocal effects between opioid peptides and human polymorphonuclear leukocytes--I. Chemical modifications of Leu-enkephalin by phorbol myristate acetate-stimulated polymorphonuclear leukocytes.
Topics: Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Humans; Hydroxylation; Luminescent Measurements; Mass Spectrometry; Neutrophils; Peptides; Phenylalanine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
The peroxidase-catalyzed oxidation of enkephalins.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Enkephalin, Leucine; Enkephalin, Methionine; Horseradish Peroxidase; Kinetics; Lactoperoxidase; Oxidation-Reduction; Peroxidase; Peroxidases; Spectrophotometry, Ultraviolet; Tyrosine | 1991 |
An enkephalin degrading aminopeptidase of human brain preserved during the vertebrate phylogeny.
Topics: Amino Acid Sequence; Amino Acids; Aminopeptidases; Amphibians; Animals; Birds; Brain; Callithrix; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fishes; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Focusing; Molecular Sequence Data; Naphthalenes; Phylogeny; Rats; Reptiles; Tyrosine | 1991 |
HPLC-ECD determination of the enzymatic hydrolysis of [leu]- and [met]enkephalin in rat plasma.
Topics: Acetylcholinesterase; Aminopeptidases; Animals; Captopril; CD13 Antigens; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Leucine; Male; Oligopeptides; Rats; Rats, Inbred Strains; Thiorphan; Tyrosine | 1990 |
Only tyrosine-containing metabolites of [Leu]enkephalin impair active avoidance conditioning in mice.
Topics: Amino Acid Sequence; Animals; Avoidance Learning; Enkephalin, Leucine; Male; Mice; Molecular Sequence Data; Motor Activity; Naloxone; Oligopeptides; Tyrosine | 1990 |
[The role of the terminal amino acids in the physiological activity of opioid peptides (lymph stimulation and vascular permeability)].
Topics: Amino Acid Sequence; Animals; Arginine; Bradykinin; Capillary Permeability; Endorphins; Enkephalin, Leucine; Lymph; Lymphatic System; Male; Mesentery; Microcirculation; Molecular Sequence Data; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tyrosine | 1990 |
Roles of tyrosine residue of enkephalin in opiate receptor recognition.
Topics: Animals; Chemical Phenomena; Chemistry; Enkephalins; Guinea Pigs; Mice; Molecular Structure; Receptors, Opioid; Tyrosine | 1989 |
Minimum-structure enkephalin analogues incorporating L-tyrosine, D(or L)-phenylalanine, and a diamine spacer.
Topics: Animals; Chemical Phenomena; Chemistry; Diamines; Enkephalins; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Phenylalanine; Structure-Activity Relationship; Tyrosine | 1989 |
Histamine activates proenkephalin A mRNA but not phenylethanolamine N-methyltransferase mRNA expression in cultured bovine adrenal chromaffin cells.
Topics: Adrenal Glands; Animals; Catecholamines; Cattle; Chromaffin System; Enkephalins; Enzyme Activation; Histamine; Hydroxylation; Oligonucleotide Probes; Phenylethanolamine N-Methyltransferase; Protein Precursors; RNA, Messenger; Tyrosine | 1989 |
Pulmonary metabolism of exogenous enkephalins in isolated perfused rat lungs.
Topics: Aminopeptidases; Animals; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Leucine; Lung; Male; Oligopeptides; Peptidyl-Dipeptidase A; Perfusion; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Tyr1-substituted and fluorescent Pya1-enkephalins bind strongly and selectively to mu and delta opiate receptors.
Topics: Alanine; Animals; Binding, Competitive; Crystallography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Pyrenes; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spectrometry, Fluorescence; Structure-Activity Relationship; Tyrosine | 1986 |
Investigation of 4-(3-hydroxyphenyl)-4-methylpipecolic acid as a conformationally restricted mimic of the tyrosyl residue of leucine-enkephalinamide.
Topics: Enkephalin, Leucine; Magnetic Resonance Spectroscopy; Molecular Conformation; Pipecolic Acids; Receptors, Opioid; Structure-Activity Relationship; Tyrosine | 1986 |
Reversed-phase high-performance liquid chromatography of tyrosine-containing metabolites of enkephalins using octanesulphonic acid as ion-pairing agent and radioactivity detection.
Topics: Alkanesulfonates; Alkanesulfonic Acids; Animals; Chromatography, High Pressure Liquid; Enkephalins; Rats; Spectrophotometry, Ultraviolet; Tyrosine | 1987 |
High-performance liquid chromatographic determination of leucine-enkephalin-like peptide in rat brain by pre-column fluorescence derivatization involving formylation followed by reaction with 1,2-diamino-4,5-dimethoxybenzene.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Keto Acids; Male; Mice; Phenylenediamines; Rats; Rats, Inbred Strains; Sialic Acids; Spectrometry, Fluorescence; Tyrosine | 1988 |
Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain.
Topics: Bacitracin; Blood-Brain Barrier; Brain; Caudate Nucleus; Enkephalin, Leucine; Female; Hippocampus; Kinetics; Male; Naloxone; Parietal Lobe; Tyrosine | 1987 |
In vitro interactions of opioid peptides with phospholipids. II. Additional spectral evidence.
Topics: Binding Sites; Circular Dichroism; Enkephalin, Leucine; Fluorescence Polarization; Liposomes; Phenylalanine; Phosphatidylserines; Spectrophotometry, Ultraviolet; Tyrosine | 1986 |
Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine).
Topics: Animals; Blood-Brain Barrier; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Male; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
NOE data at 500 MHz reveal the proximity of phenyl and tyrosine rings in enkephalin.
Topics: Enkephalins; Glycine; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Phenylalanine; Protein Conformation; Tyrosine | 1986 |
Alpha-endorphin, gamma-endorphin and their des-tyrosine fragments in rat pituitary and brain tissue.
Topics: alpha-Endorphin; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Endorphins; Enkephalins; gamma-Endorphin; Male; Microwaves; Peptide Fragments; Pituitary Gland; Rats; Tyrosine | 1980 |
Synthesis, in vitro opiate activity, and intramolecular tyrosine--tryptophan distances of [4-tryptophan]enkephalin analogues. A reassessment of conformational models of enkephalin in solution.
Topics: Animals; Chemical Phenomena; Chemistry; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Solutions; Spectrometry, Fluorescence; Structure-Activity Relationship; Thermodynamics; Tryptophan; Tyrosine | 1980 |
Degradation and oxidation of methionine enkephalin by human neutrophils.
Topics: Azides; Biotransformation; Catalase; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Neutrophils; Oxidation-Reduction; Peroxidase; Superoxide Dismutase; Superoxides; Tyrosine | 1982 |
Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity.
Topics: Analgesia; Animals; Biological Assay; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Enkephalin, Leucine; Glycine; Mice; Receptors, Opioid; Seizures; Structure-Activity Relationship; Tyrosine | 1984 |
Studies on the transport of enkephalin-like oligopeptides in rat intestinal mucosa.
Topics: Aminopeptidases; Animals; Biological Transport, Active; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Intestinal Mucosa; Jejunum; Kinetics; Leucine; Male; Oligopeptides; Puromycin; Rats; Rats, Inbred Strains; Tyrosine | 1983 |
Determination of Leu-enkephalin degradation by a soluble enzyme preparation from calf-brain striatum using reversed-phase high-performance liquid chromatography.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Corpus Striatum; Enkephalin, Leucine; Glycine; Hydrolysis; Solubility; Tyrosine | 1983 |
Synthesis and analgesic properties of two leucine-enkephalin analogues containing a conformationally restrained N-terminal tyrosine residue.
Topics: Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Male; Mice; Protein Conformation; Tyrosine; Vas Deferens | 1983 |
The assay of Met-enkephalin aminopeptidase with [125I]Met-enkephalin.
Topics: Aminopeptidases; Animals; Brain; Centrifugation, Density Gradient; Endorphins; Enkephalin, Methionine; Enkephalins; Hydrolysis; Kinetics; Methods; Puromycin; Rats; Time Factors; Tyrosine | 1982 |
[Effect of leu-enkephalin and tyrosine on lymphatic and blood microvessels].
Topics: Animals; Enkephalin, Leucine; Intestine, Small; Lymphatic System; Male; Mesenteric Arteries; Mesenteric Veins; Microcirculation; Rats; Rats, Inbred Strains; Tyrosine | 1982 |
Isolation of striatal proenkephalin and identification of a novel O-sulphated enkephalin.
Topics: Animals; Corpus Striatum; Enkephalin, Leucine; Enkephalins; Isoelectric Focusing; Molecular Weight; Protein Precursors; Rats; Tyrosine | 1982 |
De novo biosynthesis of enkephalins and their homologues in the human placenta.
Topics: Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; In Vitro Techniques; Peptide Fragments; Placenta; Pregnancy; Radioimmunoassay; Tyrosine | 1981 |
The investigation of [(4'-amino)-PHE]4-enkephalin conformation in water by the spectrofluorimetric procedure.
Topics: Endorphins; Enkephalin, Leucine; Enkephalins; Molecular Conformation; Phenylalanine; Spectrometry, Fluorescence; Tyrosine; Water | 1981 |
Nuclear magnetic resonance study of side-chain conformation of tyrosyl residue in [Met5]-enkephalin. Solvent and temperature dependence.
Topics: Dimethyl Sulfoxide; Endorphins; Enkephalins; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methionine; Methylamines; Molecular Conformation; Solvents; Temperature; Tyrosine; Water | 1980 |
Enkephalin inactivation by N-terminal tyrosine cleavage: purification and partial characterization of a highly specific enzyme from human brain.
Topics: Aminopeptidases; Brain; Corpus Striatum; Electrophoresis, Polyacrylamide Gel; Endorphins; Enkephalins; Humans; Methionine; Molecular Weight; Substrate Specificity; Tyrosine | 1980 |
Conformational analysis of linear peptides by 15N NMR spectroscopy using the enkephalin-related fragment Tyr-Gly-Gly-Phe as a model compound.
Topics: Endorphins; Enkephalins; Glycine; Magnetic Resonance Spectroscopy; Oligopeptides; Phenylalanine; Protein Conformation; Tyrosine | 1980 |
Antibiotics as inhibitors of enkephalin degradation by human brain.
Topics: Anti-Bacterial Agents; Biotransformation; Brain; Corpus Striatum; Depression, Chemical; Endorphins; Enkephalins; Humans; In Vitro Techniques; Time Factors; Tyrosine | 1980 |
Biosynthesis of enkephalins by chromaffin cells of bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; Chromaffin System; Endorphins; Enkephalins; In Vitro Techniques; Tyrosine | 1980 |
Substance P and bradykinin are natural inhibitors of CD13/aminopeptidase N.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Bradykinin; CD13 Antigens; Cell Line; Cell Membrane; Endorphins; Enkephalin, Leucine; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Protease Inhibitors; Substance P; Swine; Tyrosine | 1995 |
Fluorescence anisotropy of tyrosine using one-and two-photon excitation.
Topics: Biophysical Phenomena; Biophysics; Chemical Phenomena; Chemistry, Physical; Enkephalin, Leucine; Fluorescence Polarization; Phenol; Phenols; Photons; Ribonucleases; Spectrometry, Fluorescence; Tyrosine | 1995 |
Tyrosine-iodination converts the delta-opioid peptide antagonist TIPP to an agonist.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain Neoplasms; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Iodine; Mice; Molecular Sequence Data; Molecular Weight; Narcotic Antagonists; Neuroblastoma; Oligopeptides; Receptors, Opioid, delta; Spectrometry, Mass, Fast Atom Bombardment; Tetrahydroisoquinolines; Tumor Cells, Cultured; Tyrosine | 1995 |
Effect of differentiation on hydrolysis and association of Leu-enkephalin to K562(S) cells.
Topics: Amino Acid Sequence; Cell Differentiation; Dipeptides; Endopeptidases; Enkephalin, Leucine; Humans; Hydrolysis; Kinetics; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Tumor Cells, Cultured; Tyrosine | 1994 |
Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13).
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cyclization; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Thermodynamics; Tyrosine; Vas Deferens | 1994 |
Tyrosine phosphorylation of a 58 kDa protein induced by morphine in SK-N-SH cells.
Topics: Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Kinetics; Molecular Weight; Morphine; Naloxone; Nerve Tissue Proteins; Pertussis Toxin; Phosphorylation; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Tyrosine; Virulence Factors, Bordetella | 1994 |
Leucine enkephalin-tyrosinase reaction products--identification and biological activity.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Chromatography; Enkephalin, Leucine; Male; Mass Spectrometry; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Tyrosine; Tyrosine Phenol-Lyase | 1994 |
Mouse brain opioid receptor identification by direct ultraviolet photoaffinity labeling.
Topics: Affinity Labels; Animals; Binding Sites; Dithiothreitol; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Naloxone; Receptors, Opioid; Tritium; Tyrosine; Ultraviolet Rays | 1993 |
Intensity and anisotropy decays of [Leu5] enkephalin tyrosyl fluorescence by 10 GHz frequency-domain fluorometry.
Topics: Acrylamides; Amino Acid Sequence; Enkephalin, Leucine; Kinetics; Molecular Sequence Data; Spectrometry, Fluorescence; Temperature; Thermodynamics; Tyrosine | 1993 |
Synthesis and application of N,N-bis-(1-adamantyloxycarbonyl) amino acids.
Topics: Adamantane; Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Enkephalin, Leucine; Molecular Sequence Data; Tyrosine | 1993 |
Characterization of the aminopeptidase activity of epidermal leukotriene A4 hydrolase against the opioid dynorphin fragment 1-7.
Topics: Amino Acid Sequence; Aminopeptidases; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Epidermis; Epoxide Hydrolases; Humans; Molecular Sequence Data; Neutrophils; Peptide Fragments; Tyrosine | 1995 |
Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology.
Topics: Amino Acid Sequence; Analgesics, Opioid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oligopeptides; Opioid Peptides; Phenylalanine; Protein Binding; Protein Conformation; Receptors, Opioid; Stereoisomerism; Tyrosine | 1996 |
Periventricular penetration and disappearance of ICV Tyr-MIF-1, DAMGO, tyrosine, and albumin.
Topics: Albumins; Analgesics; Animals; Autoradiography; Brain Chemistry; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; MSH Release-Inhibiting Hormone; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Hepatic inactivation of Leu-enkephalin.
Topics: Animals; Biliary Tract; Biotransformation; CD13 Antigens; Cell Membrane; Enkephalin, Leucine; Hydrolysis; Iodine Radioisotopes; Leucine; Liver; Male; Mice; Perfusion; Protease Inhibitors; Rats; Rats, Wistar; Succinimides; Tritium; Tyrosine | 1996 |
Peroxynitrite-mediated nitration of peptides: characterization of the products by electrospray and combined gas chromatography-mass spectrometry.
Topics: Chromatography, Liquid; Enkephalin, Leucine; Gas Chromatography-Mass Spectrometry; Hemoglobins; HIV Envelope Protein gp120; Mass Spectrometry; Nitrates; Peptide Fragments; Trimethylsilyl Compounds; Tyrosine | 1997 |
Delta-opiate DPDPE in magnetically oriented phospholipid micelles: binding and arrangement of aromatic pharmacophores.
Topics: Biophysical Phenomena; Biophysics; Carbon Isotopes; Dimyristoylphosphatidylcholine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydrogen; Lipid Bilayers; Magnetic Resonance Spectroscopy; Magnetics; Micelles; Models, Molecular; Phenylalanine; Phospholipid Ethers; Phospholipids; Protein Conformation; Receptors, Opioid, delta; Tyrosine | 1997 |
Enzymatic reduction of 3-nitrotyrosine generates superoxide.
Topics: Chromatography, High Pressure Liquid; Cytochrome c Group; Electron Spin Resonance Spectroscopy; Enkephalin, Leucine; Kinetics; Mass Spectrometry; Oxidation-Reduction; Peptide Fragments; Superoxides; Trypsin; Tyrosine | 1998 |
Age-induced increase of leucine enkephalin enzyme degradation in human plasma.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aminopeptidases; Analysis of Variance; Chromatography, Gel; Chromatography, Thin Layer; Enkephalin, Leucine; Female; Glycine; Humans; Hydrolysis; Kinetics; Male; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Tyrosine | 1998 |
A high affinity, mu-opioid receptor-selective enkephalin analogue lacking an N-terminal tyrosine.
Topics: Enkephalins; Kinetics; Peptides, Cyclic; Receptors, Opioid, mu; Structure-Activity Relationship; Tyrosine | 1998 |
(2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor.
Topics: Animals; CHO Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Membranes; Protein Binding; Receptors, Opioid, delta; Sulfur Radioisotopes; Tetrahydroisoquinolines; Tyrosine | 1999 |
Peptide transport system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Capillaries; Carrier Proteins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Iodine Radioisotopes; Male; Mice; Mice, Inbred ICR; MSH Release-Inhibiting Hormone; Receptors, Opioid; Thyrotropin-Releasing Hormone; Tyrosine | 1999 |
Biological properties of opioid peptides replacing Tyr at position 1 by 2,6-dimethyl-Tyr.
Topics: Animals; Enkephalin, Leucine; Guinea Pigs; Isomerism; Mice; Opioid Peptides; Rats; Receptors, Opioid; Structure-Activity Relationship; Tyrosine | 1999 |
Effect of lithium treatments on the tyrosine-aminopeptidase activities in the rat brain and the pituitary gland.
Topics: Aminopeptidases; Animals; Brain; Enkephalins; Lithium; Male; Membranes; Nerve Tissue Proteins; Neurotransmitter Agents; Pituitary Gland; Protein Synthesis Inhibitors; Puromycin; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Tyrosine | 1999 |
Mutation of tyrosine 318 (Y318F) in the delta-opioid receptor attenuates tyrosine phosphorylation, agonist-dependent receptor internalization, and mitogen-activated protein kinase activation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Analgesics; Animals; Cell Line; CHO Cells; Conserved Sequence; Cricetinae; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phenylalanine; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Tritium; Tyrosine | 2000 |
Detection of neuropeptides using on-capillary copper complexation and capillary electrophoresis with electrochemical detection.
Topics: Angiotensins; Copper; Electrochemistry; Electrophoresis, Capillary; Enkephalin, Leucine; Humans; Neuropeptides; Oligopeptides; Peptides, Cyclic; Structure-Activity Relationship; Tyrosine | 2000 |
Chloramine-T in radiolabeling techniques. IV. Penta-O-acetyl-N-chloro-N-methylglucamine as an oxidizing agent in radiolabelling techniques.
Topics: Amino Acids, Cyclic; Chloramines; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Enkephalin, Leucine; Iodine Compounds; Iodine Radioisotopes; Meglumine; Oxidants; Tosyl Compounds; Tyrosine | 2001 |
Interaction of enkephalins with oxyradicals.
Topics: Antioxidants; Enkephalins; Free Radical Scavengers; Free Radicals; Hydrogen Peroxide; Iron; Lipid Peroxidation; Melanins; Opioid Peptides; Oxidation-Reduction; Reactive Oxygen Species; Tyrosine | 2001 |
Enkephalins: Raman spectral analysis and comparison as function of pH 1-13.
Topics: Cell Line, Tumor; Circular Dichroism; Enkephalins; Humans; Hydrogen-Ion Concentration; Leucine; Methionine; Models, Chemical; Protein Conformation; Spectrum Analysis, Raman; Tyrosine | 2003 |
2',6'-dimethylphenylalanine (Dmp) can mimic the N-terminal Tyr in opioid peptides.
Topics: Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Molecular Mimicry; Muscle Contraction; Muscle, Smooth; Oligopeptides; Opioid Peptides; Phenylalanine; Radioligand Assay; Receptors, Opioid, delta; Tyrosine; Vas Deferens | 2004 |
Cyclic enkephalin analogs containing various para-substituted phenylalanine derivatives in place of Tyr1 are potent opioid agonists.
Topics: Animals; Enkephalins; Guinea Pigs; Inhibitory Concentration 50; Mice; Narcotics; Phenylalanine; Receptors, Opioid; Tyrosine | 2005 |
Structure-activity relationships of Leu-Enkephalin analog with (4-Carboxamido)phenylalanine substituted for tyrosine: a molecular dynamics study.
Topics: Analgesics, Opioid; Computer Simulation; Enkephalin, Leucine; Hydrogen Bonding; Molecular Conformation; Molecular Structure; Phenylalanine; Receptors, Opioid, delta; Solutions; Structure-Activity Relationship; Tyrosine; Water | 2007 |
Arylation of Phe and Tyr side chains of unprotected peptides by a Suzuki-Miyaura reaction in water.
Topics: Enkephalin, Leucine; Iodoproteins; Onium Compounds; Peptides; Phenylalanine; Pyridines; Tyrosine | 2008 |
Interactions of tyrosine in Leu-enkephalin at a membrane-water interface: an ultrafast two-dimensional infrared study combined with density functional calculations and molecular dynamics simulations.
Topics: Enkephalin, Leucine; Lipid Bilayers; Molecular Dynamics Simulation; Quantum Theory; Spectrophotometry, Infrared; Tyrosine; Water | 2010 |
Stable isotope labeling method targeting terminal tyrosine for relative peptide quantitation using mass spectrometry.
Topics: Amino Acid Sequence; Chromatography, Liquid; Cysteine; Enkephalin, Leucine; Isotope Labeling; Mass Spectrometry; Molecular Sequence Data; Monophenol Monooxygenase; Neuropeptides; Tyrosine | 2010 |
Multi-component signaling complexes of the delta-opioid receptor with STAT5B and G proteins.
Topics: Amino Acid Sequence; Analgesics, Opioid; Cell Line, Transformed; Conserved Sequence; Enkephalin, Leucine; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Immunoprecipitation; Morphine; Mutation; Pertussis Toxin; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Pyrazoles; Pyrimidines; Receptors, Opioid, delta; Signal Transduction; STAT5 Transcription Factor; Transfection; Tyrosine | 2010 |
Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts.
Topics: Animals; Calcitonin; Calcium; Cell Line, Tumor; Cyclic AMP; Diazonium Compounds; Enkephalin, Leucine; Humans; Male; Methacrylates; Models, Molecular; Polyethylene Glycols; Rats; Rats, Wistar; Tyrosine | 2012 |
Superoxide reaction with tyrosyl radicals generates para-hydroperoxy and para-hydroxy derivatives of tyrosine.
Topics: Animals; Armoracia; Cattle; Enkephalin, Leucine; Horseradish Peroxidase; Hydrogen Peroxide; Models, Molecular; Oxidation-Reduction; Peptides; Superoxide Dismutase; Superoxides; Tyrosine; Xanthine Oxidase | 2012 |
Direct identification of tyrosine sulfation by using ultraviolet photodissociation mass spectrometry.
Topics: Amino Acid Sequence; Animals; Cattle; Ceruletide; Chromatography, High Pressure Liquid; Databases, Chemical; Electrochemical Techniques; Enkephalin, Leucine; Fibrinogen; Humans; Lasers; Limit of Detection; Mass Spectrometry; Microchemistry; Neuropeptides; Oligopeptides; Peptide Fragments; Photoelectron Spectroscopy; Protein Processing, Post-Translational; Sulfates; Tandem Mass Spectrometry; Tyrosine | 2014 |
The M1 family of vertebrate aminopeptidases: role of evolutionarily conserved tyrosines in the enzymatic mechanism of aminopeptidase B.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Biocatalysis; Blotting, Western; Conserved Sequence; Enkephalin, Leucine; Evolution, Molecular; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine; Vertebrates | 2015 |
Ultrafast vibrational dynamics of the tyrosine ring mode and its application to enkephalin insertion into phospholipid membranes as probed by two-dimensional infrared spectroscopy.
Topics: Density Functional Theory; Enkephalins; Lipid Bilayers; Molecular Conformation; Phospholipids; Spectroscopy, Fourier Transform Infrared; Temperature; Tyrosine; Vibration | 2021 |