enkephalin, leucine and phenylalanine

enkephalin, leucine has been researched along with phenylalanine in 94 studies

Research

Studies (94)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (32.98)	18.7374
1990's	36 (38.30)	18.2507
2000's	24 (25.53)	29.6817
2010's	2 (2.13)	24.3611
2020's	1 (1.06)	2.80

Authors

Authors	Studies
Higashijima, T; Kobayashi, J; Miyazawa, T; Nagai, U	1
Akil, H; Barchas, JD; Sullivan, S	1
Cabassi, F; Guarneri, M; Tomatis, R; Zetta, L	1
Fournie-Zaluski, MC; Gacel, G; Lecomte, JM; Roques, BP; Senault, B	1
Bhargava, HN	1
Baamonde, A; Fournie-Zaluski, MC; Roques, BP; Ruiz-Gayo, M; Turcaud, S	1
Anthony, E; Beardsley, PM; Chandrakumar, NS; Drury, B; Lopez, OT; Reichman, M; Savage, MA; Stapelfeld, A; Williamson, LN	1
Baamonde, A; Daugé, V; Fournié-Zaluski, MC; Fulga, IG; Roques, BP; Ruiz-Gayo, M; Turcaud, S	1
Durieux, C; Fournié-Zaluski, MC; Roques, BP; Ruiz-Gayo, M	1
Guerin, MC; Slaoui-Hasnaoui, A; Torreilles, J	1
Fournie-Zaluski, MC; Noble, F; Roques, BP; Soleilhac, JM; Soroca-Lucas, E; Turcaud, S	1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP	1
Golbraikh, AA; Nikiforovich, GV; Shenderovich, MD	1
Fournié-Zaluski, MC; Noble, F; Peyroux, J; Roques, BP; Schmidt, C	1
Feger, J; Maldonado, R; Roques, BP; Waksman, G	1
Balodis, J; Golbraikh, AA; Nikiforovich, GV; Shenderovich, MD	1
Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP	1
Dygai, AM; Goldberg, ED; Shakhov, VP; Zakharova, O	1
Hobbs, RN	1
Gasparík, J	1
Delay-Goyet, P; Meucci, E; Roques, BP; Zajac, JM	1
Gintzler, AR; Jacobson, AR; Sayre, LM	1
Herblin, WF; Kauer, JC; Tam, SW	1
Nurmikko, T; Pertovaara, A; Pöntinen, PJ	1
Goodman, M; Nguyen, TM; Richman, SJ; Schiller, PW	1
Kimura, H; Mapelli, C; Stammer, CH	1
Millinger, GS	1
Hoffman, J; Ramamurthy, S; Schoenfeld, L; Walsh, NE	1
D'Alagni, M; Roda, LG; Vita, F	1
Han, JS; Yuan, H	1
Dhingra, MM; Gupta, G; Sarma, MH; Sarma, RH	1
Johnston, MV; Singer, HS	1
Ehrenpreis, S	2
Coy, DH; Kastin, AJ	1
Costa, T; Shimohigashi, Y; Stammer, CH; Vonvoigtlander, PF	1
Izumiya, N; Shimohigashi, Y; Waki, M	1
Adelstein, SJ; Carr, SA; Kim, HJ; Mee, LK; Reinhold, VN; Taub, IA	1
Laubie, M; Schmitt, H	1
Barre, M; Bernard, L; Deumier, R; Donzelle, G; Lacome, M; Lanier, M; Mourtada, MB	1
Bodnar, RJ; Lattner, M; Wallace, MM	1
Jankowski, A; Siemion, IZ; Szewczuk, Z	1
Eshel, Y; Keren, O; Korczyn, AD	1
Baudet, J; Florentin, D; Garbay-Jaureguiberry, C; Roques, BP	1
Gibert-Rahola, J; Maldonado, R; Mico, JA; Roques, BP; Tejedor-Real, P	1
Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP	1
Corringer, PJ; Dauge, V; Roques, BP	1
Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O	1
Bouzit, H; Hepp, AM; Heyl, DL; Johnson, TW; Kurtz, KR; Mousigian, C; Schmitter, SJ	1
Fournié-Zaluski, MC; Noble, F; Roques, BP	2
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O	1
Noble, F; Roques, BP; Smadja, C	1
Davis, P; Heyl, DL; Lomize, A; Mosberg, HI; Mousigian, C; Nordan, I; Omnaas, JR; Porreca, F	1
Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O	1
Derrien, M; Noble, F; Roques, BP	1
Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Smadja, C; Turcaud, S	1
Davis, P; Frycia, A; Hruby, VJ; Jaspers, H; Porreca, F; Toth, G; Tourwé, D; Van Binst, G; Verheyden, P; Verschueren, K	1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F	1
Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P	1
Coric, P; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F; Smadja, C	1
Chuman, Y; Costa, T; Shimohigashi, Y; Yasunaga, T	1
Davis, P; Haaseth, RC; Hruby, VJ; Porreca, F; Yamamura, HI; Zalewska, T	1
Abumrad, NN; Dorton, S; Garlick, PJ; Hashiguchi, Y; McNurlan, MA; Molina, PE; Reddy, D	1
Lin, M; Petersheim, M; Rinaldi, F; Shapiro, MJ	1
Liupina, IuV; Maldonado, R; Medvedeva, OF; Sudakov, SK; Tiurina, IV	1
Gilbert-Rahola, J; Maldonado, R; Micó, JA; Roques, BP; Smadja, C; Tejedor-Real, P	1
Andria, ML; Esposito, DH; Hiller, JM; Kramer, HK; Kushner, SA; Simon, EJ	1
Boudinot, E; Denavit-Saubié, M; Fournié-Zaluski, M; Foutz, AS; Morin-Surun, M; Roques, BP	1
Ambo, A; Hirabuki, M; Ouchi, H; Sasaki, Y; Yamamoto, Y	1
Han, H; Liu, G; Shangguan, D; Zhao, R; Zhao, Y	1
Benavides, J; Fournié-Zaluski, MC; Nieto, MM; Noble, F; Roques, BP; Walker, J; Wilson, J	1
Brodzik-Bienkowska, A; Hruby, VJ; Kosson, D; Kosson, P; Lachwa-From, M; Lipkowski, AW; Misicka, A	1
Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Noble, F; Roques, BP	1
Fowler, CB; Mosberg, HI	1
Besson, JM; Buritova, J; Catheline, G; Fournié-Zaluski, MC; Le Guen, S; Roques, BP	1
Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP	1
Ambo, A; Ariizumi, T; Igari, Y; Kohara, H; Niizuma, H; Sasaki, A; Sasaki, Y; Sato, K	1
Chung, NN; Lemieux, C; Schiller, PW; Weltrowska, G	1
Cordonnier, L; Noble, F; Roques, BP; Sanchez, M	1
Guen, SL; Kieffer, BL; Nieto, MM; Noble, F; Roques, BP	1
Canestrelli, C; Crété, D; Jardinaud, F; Ledent, C; Noble, F; Roques, BP	1
Bernard, D; Coop, A; MacKerell, AD	1
Bilkei-Gorzo, A; Michel, K; Noble, F; Roques, BP; Zimmer, A	1
Hwang, CC; Wang, YC; Wu, YC; Yeh, CC	1
Jutkiewicz, EM	1
Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A	1
Arsequell, G; Ballesteros, A; Barluenga, J; Valencia, G; Vilaró, M	1
Merz, K; Neundorf, I; Peindy N'Dongo, HW; Schatzschneider, U	1
Cabañero, D; Célérier, E; García-Nogales, P; Maldonado, R; Mata, M; Puig, MM; Roques, BP	1
Girault, HH; Méndez, MA; Prudent, M; Su, B	1
Davis, P; Feliciani, F; Hruby, VJ; Lai, J; Lucente, G; Ma, SW; Mollica, A; Pinnen, F; Porreca, F; Stefanucci, A	1
Altman, RA; Blaine, AT; Cassell, RJ; Cui, H; Cummins, BR; Mores, KL; Sharma, KK; Su, H; van Rijn, RM	1
Bansal, N; Fonseca, A; Gillis, J; Gulati, A; Horine, SV; Kuppalli, S; Mendelson, A; Southerland, WA	1

Reviews

6 review(s) available for enkephalin, leucine and phenylalanine

Article	Year
Neutral amino acid therapy for the management of chronic pain. Cranio : the journal of craniomandibular practice, 1986, Volume: 4, Issue:2 Topics: Animals; Chronic Disease; Enkephalins; Humans; Pain; Phenylalanine; Serotonin; Transcutaneous Electric Nerve Stimulation; Tryptophan	1986
Brain neurotransmitters and neuromodulators in pediatrics. Pediatrics, 1982, Volume: 70, Issue:1 Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Brain; Child; Endorphins; Enkephalins; Epilepsy; Humans; Movement Disorders; Neurotransmitter Agents; Pain; Phenylalanine; Psychotic Disorders; Receptors, Neurotransmitter	1982
Structure-CNS activity studies with the enkephalins. Pharmacology & therapeutics, 1980, Volume: 10, Issue:3 Topics: Analgesia; Animals; Brain; Endorphins; Enkephalins; Glycine; Methionine; Phenylalanine; Receptors, Opioid; Structure-Activity Relationship; Tyrosine	1980
[Synthetic enkephalins and multiple opiate receptors]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1983, Volume: 28, Issue:12 Topics: Animals; Enkephalins; Guinea Pigs; Mice; Phenylalanine; Rats; Receptors, Opioid; Structure-Activity Relationship; Swine; Tyrosine	1983
RB101-mediated protection of endogenous opioids: potential therapeutic utility? CNS drug reviews, 2007,Summer, Volume: 13, Issue:2 Topics: Aminopeptidases; Animals; Cholecystokinin; Disulfides; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Mice; Phenylalanine; Prodrugs; Rats	2007
Dual Enkephalinase Inhibitors and Their Role in Chronic Pain Management. Current pain and headache reports, 2021, Mar-24, Volume: 25, Issue:5 Topics: CD13 Antigens; Chronic Pain; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Humans; Neprilysin; Phenylalanine; Propionates; Propylamines	2021

Trials

1 trial(s) available for enkephalin, leucine and phenylalanine

Article	Year
Analgesic effectiveness of D-phenylalanine in chronic pain patients. Archives of physical medicine and rehabilitation, 1986, Volume: 67, Issue:7 Topics: Animals; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Enkephalins; Female; Humans; Male; Mice; Middle Aged; Nociceptors; Pain; Phenylalanine; Random Allocation; Rats	1986

Other Studies

87 other study(ies) available for enkephalin, leucine and phenylalanine

Article	Year
Nuclear magnetic resonance study of side-chain conformation of phenylalanine residue in [Met5]-enkephalin: solvent, pH, and temperature dependence. Biochimica et biophysica acta, 1979, Mar-27, Volume: 577, Issue:1 Topics: Amino Acid Sequence; Enkephalins; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Conformation; Phenylalanine; Protein Conformation; Solvents; Temperature	1979
In vitro degradation of enkephalin: evidence for cleavage at the Gly-Phe bond. Communications in psychopharmacology, 1978, Volume: 2, Issue:6 Topics: Animals; Biodegradation, Environmental; Brain; Cattle; Endorphins; Enkephalins; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Phenylalanine; Rats	1978
270-MHz 1H nuclear-magnetic-resonance study of Met-enkephalin in water. Conformational behaviour as a function of pH. European journal of biochemistry, 1979, Apr-02, Volume: 95, Issue:2 Topics: Amides; Endorphins; Enkephalins; Glycine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methionine; Molecular Conformation; Phenylalanine; Protons; Tyrosine; Water	1979
Demonstration of the crucial role of the phenylalanine moiety in enkephalin analogues for differential recognition of the mu- and delta-receptors. European journal of pharmacology, 1979, Nov-23, Volume: 60, Issue:1 Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phenylalanine; Receptors, Opioid; Vas Deferens	1979
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice. Anesthesiology, 1979, Volume: 51, Issue:5 Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine	1979
In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding. Brain research, 1992, Feb-07, Volume: 571, Issue:2 Topics: Analgesics; Animals; Brain; Cell Membrane; Diprenorphine; Disulfides; Enkephalins; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylalanine; Receptors, Opioid; Stress, Psychological; Tritium	1992
Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. Journal of medicinal chemistry, 1992, Aug-07, Volume: 35, Issue:16 Topics: Amides; Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glycine; Male; Mice; Molecular Sequence Data; Muscle Contraction; Neuroblastoma; Peptides, Cyclic; Phenylalanine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured; Tyrosine; Vas Deferens	1992
Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation. European journal of pharmacology, 1992, Jun-05, Volume: 216, Issue:2 Topics: Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Disulfides; Dopamine; Enkephalins; Male; Mice; Motor Activity; Phenylalanine; Prodrugs; Receptors, Dopamine D1; Receptors, Opioid, delta; Swimming	1992
Stimulation of delta-opioid receptors reduces the in vivo binding of the cholecystokinin (CCK)-B-selective agonist [3H]pBC 264: evidence for a physiological regulation of CCKergic systems by endogenous enkephalins. Journal of neurochemistry, 1992, Volume: 59, Issue:5 Topics: Analgesics; Analgesics, Opioid; Animals; Cholecystokinin; Dipeptides; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Narcotic Antagonists; Peptide Fragments; Phenylalanine; Prodrugs; Receptors, Cholecystokinin; Receptors, Opioid	1992
Reciprocal effects between opioid peptides and human polymorphonuclear leukocytes--I. Chemical modifications of Leu-enkephalin by phorbol myristate acetate-stimulated polymorphonuclear leukocytes. Biochemical pharmacology, 1992, Feb-04, Volume: 43, Issue:3 Topics: Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Humans; Hydroxylation; Luminescent Measurements; Mass Spectrometry; Neutrophils; Peptides; Phenylalanine; Tetradecanoylphorbol Acetate; Tyrosine	1992
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:1 Topics: Aminopeptidases; Analgesia; Analgesics; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Disulfides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Neprilysin; Phenylalanine; Prodrugs; Rats; Rats, Inbred Strains	1992
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:4 Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan	1992
Conformational features responsible for the binding of cyclic analogues of enkephalin to opioid receptors. III. Probable binding conformations of mu-agonists with phenylalanine in position 3. International journal of peptide and protein research, 1991, Volume: 37, Issue:4 Topics: Amino Acid Sequence; Endorphins; Enkephalins; Molecular Sequence Data; Molecular Structure; Oligopeptides; Opioid Peptides; Phenylalanine; Protein Conformation; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship	1991
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests. European journal of pharmacology, 1991, Jan-10, Volume: 192, Issue:2 Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Hydroxamic Acids; Male; Mice; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains	1991
Naloxone-induced withdrawal syndrome after administration of selective opioid agonists or after activation of the endogenous enkephalinergic system. Progress in clinical and biological research, 1990, Volume: 328 Topics: Animals; Behavior, Animal; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Weight Loss	1990
Conformational features responsible for binding of cyclic analogues of enkephalin to opioid receptors. I. Low-energy peptide backbone conformers of analogues containing Phe4. International journal of peptide and protein research, 1990, Volume: 36, Issue:1 Topics: Amino Acid Sequence; Animals; Enkephalins; Molecular Sequence Data; Molecular Structure; Phenylalanine; Protein Conformation; Rats; Receptors, Opioid; Thermodynamics	1990
Differences in physical dependence induced by selective mu or delta opioid agonists and by endogenous enkephalins protected by peptidase inhibitors. Brain research, 1990, Jun-18, Volume: 520, Issue:1-2 Topics: Animals; Cerebral Ventricles; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Injections, Intraventricular; Male; Naloxone; Neprilysin; Oligopeptides; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values; Substance Withdrawal Syndrome; Substance-Related Disorders	1990
The modulating influence of enkephalins on the bone marrow haemopoiesis in stress. Folia biologica, 1990, Volume: 36, Issue:6 Topics: Animals; Bone Marrow; Cell Count; Cell Differentiation; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hematopoiesis; Male; Mice; Naloxone; Phenylalanine; Restraint, Physical; Stress, Physiological; Time Factors	1990
Solid-phase immunoassay of serum antibodies to peptides. Covalent antigen binding to adsorbed phenylalanine-lysine copolymers. Journal of immunological methods, 1989, Feb-24, Volume: 117, Issue:2 Topics: Adsorption; Animals; Antibodies; Enkephalins; Enzyme-Linked Immunosorbent Assay; Glucagon; Immunoassay; Lysine; Peptides; Phenylalanine; Rabbits	1989
Biologically active conformation of [Met5]- and [Leu5]enkephalin on delta opioid receptor. European journal of pharmacology, 1989, Dec-05, Volume: 172, Issue:6 Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Models, Molecular; Molecular Sequence Data; Muscle, Smooth; Phenylalanine; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta	1989
Binding in vivo of selective mu and delta opioid receptor agonists: opioid receptor occupancy by endogenous enkephalins. European journal of pharmacology, 1989, Nov-21, Volume: 171, Issue:2-3 Topics: Animals; Brain; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; In Vitro Techniques; Injections; Kinetics; Male; Mice; Morphine; Oligopeptides; Phenylalanine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan	1989
Minimum-structure enkephalin analogues incorporating L-tyrosine, D(or L)-phenylalanine, and a diamine spacer. Journal of medicinal chemistry, 1989, Volume: 32, Issue:8 Topics: Animals; Chemical Phenomena; Chemistry; Diamines; Enkephalins; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Phenylalanine; Structure-Activity Relationship; Tyrosine	1989
Photoinactivation of the mu opioid receptor using a novel synthetic morphiceptin analog. European journal of pharmacology, 1987, Jul-23, Volume: 139, Issue:3 Topics: Affinity Labels; Animals; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Light; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu	1987
Attenuation of tourniquet-induced pain in man by D-phenylalanine, a putative inhibitor of enkephalin degradation. Acupuncture & electro-therapeutics research, 1987, Volume: 12, Issue:3-4 Topics: Adult; Arm; Double-Blind Method; Enkephalins; Female; Humans; Ischemia; Male; Middle Aged; Pain; Phenylalanine; Pressure; Tourniquets	1987
Synthesis and biological activity of linear and cyclic enkephalins modified at the Gly3-Phe4 amide bond. International journal of peptide and protein research, 1985, Volume: 25, Issue:6 Topics: Animals; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalins; Glycine; Guinea Pigs; Ileum; Indicators and Reagents; Magnetic Resonance Spectroscopy; Optical Rotation; Phenylalanine; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship	1985
Synthesis of four diastereomeric enkephalins incorporating cyclopropyl phenylalanine. International journal of peptide and protein research, 1986, Volume: 28, Issue:4 Topics: Animals; Binding, Competitive; Brain; Circular Dichroism; Cyclopropanes; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Male; Naloxone; Phenylalanine; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship	1986
In vitro interactions of opioid peptides with phospholipids. II. Additional spectral evidence. International journal of peptide and protein research, 1986, Volume: 28, Issue:3 Topics: Binding Sites; Circular Dichroism; Enkephalin, Leucine; Fluorescence Polarization; Liposomes; Phenylalanine; Phosphatidylserines; Spectrophotometry, Ultraviolet; Tyrosine	1986
[Electroacupuncture accelerates the biogenesis of central enkephalins in the rat]. Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:3 Topics: Acupuncture Therapy; Aminopeptidases; Animals; Brain; Electric Stimulation Therapy; Enkephalin, Leucine; Enkephalin, Methionine; Female; Leucine; Male; Phenylalanine; Radioimmunoassay; Rats; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation	1985
NOE data at 500 MHz reveal the proximity of phenyl and tyrosine rings in enkephalin. FEBS letters, 1986, Mar-31, Volume: 198, Issue:2 Topics: Enkephalins; Glycine; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Phenylalanine; Protein Conformation; Tyrosine	1986
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Acupuncture & electro-therapeutics research, 1982, Volume: 7, Issue:2-3 Topics: Acupuncture Therapy; Analgesia; Anti-Inflammatory Agents; Biotransformation; Endorphins; Enkephalins; Forecasting; Humans; Neprilysin; Pain, Intractable; Phenylalanine; Protease Inhibitors	1982
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:4 Topics: Acupuncture Therapy; Animals; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Morphine Dependence; Neprilysin; Nociceptors; Pain; Phenylalanine; Protease Inhibitors; Receptors, Opioid	1982
Synthesis and biological activity of delta Phe4-enkephalins. International journal of peptide and protein research, 1983, Volume: 22, Issue:4 Topics: Analgesia; Animals; Biological Assay; Brain; Cell Membrane; Enkephalins; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Phenylalanine; Rats; Receptors, Opioid; Structure-Activity Relationship	1983
Binding site specificity of gamma-radiation-induced crosslinking between phenylalanine and a phenylalanine-containing tetrapeptide. Radiation research, 1984, Volume: 100, Issue:1 Topics: Amino Acids; Binding Sites; Cobalt Radioisotopes; Enkephalin, Leucine; Gamma Rays; Gas Chromatography-Mass Spectrometry; Phenylalanine	1984
Indication for central vagal endorphinergic control of heart rate in dogs. European journal of pharmacology, 1981, May-22, Volume: 71, Issue:4 Topics: Analgesia; Animals; Brain; Captopril; Dipeptides; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Heart Rate; Male; Oligopeptides; Phenylalanine; Physostigmine; Potassium; Puromycin; Vagus Nerve; Veratridine	1981
[Curing trial of complicated oncologic pain by D-phenylalanine (author's transl)]. Anesthesie, analgesie, reanimation, 1981, Volume: 38, Issue:11-12 Topics: Affect; Aged; Analgesics; Drug Evaluation; Enkephalins; Female; Humans; Male; Middle Aged; Neoplasms; Pain, Intractable; Phenylalanine	1981
Antagonism of stress-induced analgesia by D-phenylalanine, an anti-enkephalinase. Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:6 Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Morphine; Phenylalanine; Physical Exertion; Rats	1980
The investigation of [(4'-amino)-PHE]4-enkephalin conformation in water by the spectrofluorimetric procedure. Acta biochimica Polonica, 1981, Volume: 28, Issue:1 Topics: Endorphins; Enkephalin, Leucine; Enkephalins; Molecular Conformation; Phenylalanine; Spectrometry, Fluorescence; Tyrosine; Water	1981
Enkephalin mydriasis in mice. European journal of pharmacology, 1980, Jul-25, Volume: 65, Issue:2-3 Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Mydriatics; Naloxone; Phenylalanine	1980
Conformational analysis of linear peptides by 15N NMR spectroscopy using the enkephalin-related fragment Tyr-Gly-Gly-Phe as a model compound. FEBS letters, 1980, Jun-30, Volume: 115, Issue:2 Topics: Endorphins; Enkephalins; Glycine; Magnetic Resonance Spectroscopy; Oligopeptides; Phenylalanine; Protein Conformation; Tyrosine	1980
Implication of endogenous opioid system in the learned helplessness model of depression. Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:1 Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Depression; Electroshock; Endorphins; Enkephalins; Helplessness, Learned; Hydroxamic Acids; Imipramine; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar	1995
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test. European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2 Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu	1995
CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101. Pharmacology, biochemistry, and behavior, 1995, Volume: 50, Issue:2 Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalins; Enzyme Inhibitors; Male; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Phenylalanine; Receptors, Cholecystokinin	1995
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308. British journal of pharmacology, 1995, Volume: 114, Issue:5 Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss	1995
Substitution of aromatic and nonaromatic amino acids for the Phe3 residue in the delta-selective opioid peptide deltorphin I: effects on binding affinity and selectivity. International journal of peptide and protein research, 1994, Volume: 44, Issue:5 Topics: Amino Acid Sequence; Analgesics; Enkephalins; Kinetics; Molecular Sequence Data; Oligopeptides; Phenylalanine; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Tritium	1994
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation. Neuropharmacology, 1994, Volume: 33, Issue:1 Topics: Abdominal Muscles; Aminopeptidases; Analgesics; Animals; CD13 Antigens; Disulfides; Enkephalins; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Phenylalanine	1994
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation. Pain, 1994, Volume: 58, Issue:1 Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley	1994
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3 Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide	1994
Development of a model for the delta opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). Journal of medicinal chemistry, 1994, Dec-09, Volume: 37, Issue:25 Topics: Amino Acid Sequence; Aminobutyrates; Animals; Cyclization; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Molecular Sequence Data; Muscle Contraction; Phenylalanine; Protein Conformation; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Vas Deferens	1994
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:1 Topics: Adamantane; Analgesics; Animals; Benzodiazepinones; Dipeptides; Disulfides; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Nociceptors; Pain Measurement; Phenylalanine; Phenylurea Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Regression Analysis; Tail	1994
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain. British journal of pharmacology, 1993, Volume: 109, Issue:4 Topics: Amino Acid Sequence; Analgesics; Animals; Cholecystokinin; Disulfides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Oligopeptides; Pain; Pain Measurement; Peptide Fragments; Phenylalanine; Sincalide; Spinal Cord	1993
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice. European journal of pharmacology, 1993, Jan-12, Volume: 230, Issue:2 Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders	1993
Opposite role of CCKA and CCKB receptors in the modulation of endogenous enkephalin antidepressant-like effects. Psychopharmacology, 1995, Volume: 120, Issue:4 Topics: Analgesics; Animals; Antidepressive Agents; Benzodiazepinones; Cholecystokinin; Disulfides; Enkephalins; Male; Mice; Mice, Inbred Strains; Motor Activity; Peptide Fragments; Phenylalanine; Phenylurea Compounds; Receptors, Cholecystokinin	1995
Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology. Biopolymers, 1996, Volume: 38, Issue:1 Topics: Amino Acid Sequence; Analgesics, Opioid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oligopeptides; Opioid Peptides; Phenylalanine; Protein Binding; Protein Conformation; Receptors, Opioid; Stereoisomerism; Tyrosine	1996
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism. British journal of pharmacology, 1996, Volume: 119, Issue:1 Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome	1996
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice. Anesthesia and analgesia, 1997, Volume: 84, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration	1997
CCK-B receptors in the limbic system modulate the antidepressant-like effects induced by endogenous enkephalins. Psychopharmacology, 1997, Volume: 132, Issue:3 Topics: Amygdala; Animals; Caudate Nucleus; Disulfides; Enkephalins; Enzyme Inhibitors; Hormone Antagonists; Indoles; Injections, Intraventricular; Limbic System; Male; Meglumine; Mice; Motor Activity; Neprilysin; Nucleus Accumbens; Phenylalanine; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin	1997
Discrimination of a novel type of rat brain delta opioid receptors by enkephalin analog containing structurally constrained cyclopropylphenylalanine (inverted delta Phe). Biochemistry and molecular biology international, 1997, Volume: 42, Issue:6 Topics: Animals; Brain; Cyclopropanes; Dose-Response Relationship, Drug; Enkephalins; Isomerism; Phenylalanine; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship	1997
Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands. The journal of peptide research : official journal of the American Peptide Society, 1997, Volume: 50, Issue:3 Topics: Animals; Binding, Competitive; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mass Spectrometry; Mice; Muscle Contraction; Muscle, Smooth; Phenylalanine; Rats; Receptors, Opioid, delta; Vas Deferens	1997
Central opiate mu-receptor-mediated suppression of tissue protein synthesis. The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2 Topics: Adenosine Triphosphate; Animals; Bicarbonates; Carbon Dioxide; Cerebral Ventricles; Deuterium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydrogen-Ion Concentration; Injections, Intraventricular; Intestinal Mucosa; Kidney; Liver; Male; Muscle, Skeletal; Organ Specificity; Oxygen; Oxyhemoglobins; Partial Pressure; Phenylalanine; Phosphocreatine; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Regression Analysis; Respiration; Spleen	1997
Delta-opiate DPDPE in magnetically oriented phospholipid micelles: binding and arrangement of aromatic pharmacophores. Biophysical journal, 1997, Volume: 73, Issue:6 Topics: Biophysical Phenomena; Biophysics; Carbon Isotopes; Dimyristoylphosphatidylcholine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydrogen; Lipid Bilayers; Magnetic Resonance Spectroscopy; Magnetics; Micelles; Models, Molecular; Phenylalanine; Phospholipid Ethers; Phospholipids; Protein Conformation; Receptors, Opioid, delta; Tyrosine	1997
[Characteristics of effects of mu-, delta-, and kappa-opioid agonists and enkephalinase inhibitor RB101 in rats of two inbred strains]. Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 125, Issue:5 Topics: Analgesics; Animals; Depression, Chemical; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Male; Motor Activity; Neprilysin; Oligopeptides; Pain Measurement; Peptides; Phenylalanine; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1998
Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model. European journal of pharmacology, 1998, Jul-31, Volume: 354, Issue:1 Topics: Analgesics; Animals; Behavior, Animal; Disulfides; Drug Interactions; Enkephalins; Helplessness, Learned; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta	1998
Mutation of tyrosine 318 (Y318F) in the delta-opioid receptor attenuates tyrosine phosphorylation, agonist-dependent receptor internalization, and mitogen-activated protein kinase activation. Brain research. Molecular brain research, 2000, Jun-23, Volume: 79, Issue:1-2 Topics: Amino Acid Sequence; Amino Acid Substitution; Analgesics; Animals; Cell Line; CHO Cells; Conserved Sequence; Cricetinae; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phenylalanine; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Tritium; Tyrosine	2000
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration. Pain, 2001, Feb-01, Volume: 90, Issue:1-2 Topics: Analgesics; Animals; Cats; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Mice; Naloxone; Narcotic Antagonists; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiration	2001
Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4. Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3 Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Ileum; Inhibitory Concentration 50; Male; Muscle Contraction; Phenylalanine; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptosomes; Vas Deferens	2001
Derivatization and fluorescence detection of amino acids and peptides with 9-fluorenylmethyl chloroformate on the surface of a solid adsorbent. Analytical chemistry, 2001, May-01, Volume: 73, Issue:9 Topics: Amino Acids; Chromatography; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Fluorenes; gamma-Aminobutyric Acid; Glutamic Acid; Indicators and Reagents; Lysine; Peptides; Phenylalanine; Reproducibility of Results; Serine; Spectrometry, Fluorescence; Substance P; Valine	2001
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management. Neuropharmacology, 2001, Volume: 41, Issue:4 Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disulfides; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Morphine; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time	2001
Biological properties of a new fluorescent biphalin fragment analogue. Life sciences, 2002, Jan-11, Volume: 70, Issue:8 Topics: Analgesia; Analgesics; Animals; Dansyl Compounds; Enkephalins; Fluorescent Dyes; Male; Pain; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu	2002
RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level. European journal of pharmacology, 2002, Apr-26, Volume: 441, Issue:3 Topics: Analgesics; Animals; Disulfides; Drug Tolerance; Enkephalins; Enzyme Inhibitors; Male; Morphine; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord	2002
Development and validation of opioid ligand-receptor interaction models: the structural basis of mu vs delta selectivity. The journal of peptide research : official journal of the American Peptide Society, 2002, Volume: 60, Issue:6 Topics: Binding Sites; Binding, Competitive; Enkephalins; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Peptides, Cyclic; Phenylalanine; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Substrate Specificity	2002
Further evidence for the interaction of mu- and delta-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S). A spinal c-Fos protein study in the rat under carrageenin inflammation. Brain research, 2003, Mar-28, Volume: 967, Issue:1-2 Topics: Analgesics; Animals; Carrageenan; Disulfides; Edema; Enkephalins; Gene Expression Regulation; Inflammation; Male; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord	2003
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord. European journal of pain (London, England), 2003, Volume: 7, Issue:3 Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord	2003
2',6'-dimethylphenylalanine (Dmp) can mimic the N-terminal Tyr in opioid peptides. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:2 Topics: Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Molecular Mimicry; Muscle Contraction; Muscle, Smooth; Oligopeptides; Opioid Peptides; Phenylalanine; Radioligand Assay; Receptors, Opioid, delta; Tyrosine; Vas Deferens	2004
Cyclic enkephalin analogs containing various para-substituted phenylalanine derivatives in place of Tyr1 are potent opioid agonists. The journal of peptide research : official journal of the American Peptide Society, 2005, Volume: 65, Issue:1 Topics: Animals; Enkephalins; Guinea Pigs; Inhibitory Concentration 50; Mice; Narcotics; Phenylalanine; Receptors, Opioid; Tyrosine	2005
Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment. Neuroscience, 2005, Volume: 135, Issue:1 Topics: Amisulpride; Animals; Behavior, Animal; Disulfides; Dopamine Antagonists; Enkephalins; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Sulpiride; Swimming	2005
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors. Neuroscience, 2005, Volume: 135, Issue:2 Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors	2005
CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited. Brain research, 2005, Nov-23, Volume: 1063, Issue:1 Topics: Analysis of Variance; Animals; Anxiety; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Female; Immobility Response, Tonic; Male; Mice; Mice, Knockout; Motor Activity; Pain Threshold; Phenylalanine; Receptor, Cannabinoid, CB1	2005
Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity. Journal of medicinal chemistry, 2007, Apr-19, Volume: 50, Issue:8 Topics: Animals; Cell Line, Tumor; Enkephalin, Leucine; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Molecular Conformation; Phenylalanine; Quantitative Structure-Activity Relationship; Rats; Receptors, Opioid, delta	2007
Preproenkephalin knockout mice show no depression-related phenotype. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:11 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Hindlimb Suspension; Immobility Response, Tonic; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Motor Activity; Nialamide; Phenotype; Phenylalanine; Protein Precursors; Swimming; Vocalization, Animal	2007
Structure-activity relationships of Leu-Enkephalin analog with (4-Carboxamido)phenylalanine substituted for tyrosine: a molecular dynamics study. Biopolymers, 2007, Jun-15, Volume: 86, Issue:3 Topics: Analgesics, Opioid; Computer Simulation; Enkephalin, Leucine; Hydrogen Bonding; Molecular Conformation; Molecular Structure; Phenylalanine; Receptors, Opioid, delta; Solutions; Structure-Activity Relationship; Tyrosine; Water	2007
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours. Psychopharmacology, 2008, Volume: 196, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming	2008
Arylation of Phe and Tyr side chains of unprotected peptides by a Suzuki-Miyaura reaction in water. Organic letters, 2008, Aug-07, Volume: 10, Issue:15 Topics: Enkephalin, Leucine; Iodoproteins; Onium Compounds; Peptides; Phenylalanine; Pyridines; Tyrosine	2008
Synthesis, characterization, X-ray crystallography, and cytotoxicity of a cymantrene keto carboxylic acid for IR labelling of bioactive peptides on a solid support. Journal of inorganic biochemistry, 2008, Volume: 102, Issue:12 Topics: Carboxylic Acids; Cell Line, Tumor; Enkephalins; Humans; Organometallic Compounds; Peptides; Phenylalanine; Spectrophotometry, Infrared	2008
The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. Pain, 2009, Volume: 141, Issue:1-2 Topics: Analgesics; Animals; Disease Models, Animal; Disulfides; Down-Regulation; Enkephalins; Ganglia, Spinal; Male; Methyl Ethers; Mice; Pain Measurement; Pain Threshold; Pain, Postoperative; Phenylalanine; Piperidines; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Remifentanil; RNA, Messenger; Sevoflurane; Spinal Cord; Time Factors	2009
Peptide-phospholipid complex formation at liquid-liquid interfaces. Analytical chemistry, 2008, Dec-15, Volume: 80, Issue:24 Topics: 1,2-Dipalmitoylphosphatidylcholine; Angiotensin III; Dipeptides; Electrochemistry; Enkephalin, Leucine; Lithium; Lysine; Peptide Fragments; Phenylalanine; Spectrometry, Mass, Electrospray Ionization	2008
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers. Amino acids, 2011, Volume: 40, Issue:5 Topics: Enkephalins; Hydrazines; Molecular Structure; Phenylalanine; Stereoisomerism	2011
The Meta-Position of Phe Molecules (Basel, Switzerland), 2019, Dec-12, Volume: 24, Issue:24 Topics: Animals; CHO Cells; Cricetulus; Enkephalin, Leucine; Humans; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction	2019