enkephalin, leucine has been researched along with naltrexone in 558 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 140 (25.09) | 18.7374 |
| 1990's | 325 (58.24) | 18.2507 |
| 2000's | 64 (11.47) | 29.6817 |
| 2010's | 26 (4.66) | 24.3611 |
| 2020's | 3 (0.54) | 2.80 |
| Authors | Studies |
|---|---|
| Lipkowski, AW; Portoghese, PS; Tam, SW | 1 |
| Coale, EH; Hein, DW; Herling, S; Valentino, RJ; Woods, JH | 1 |
| Calne, DB; Chase, TN; Eisler, T; Nutt, JG; Rosin, AJ | 1 |
| Costa, E; Dill, RE | 1 |
| Terenius, L | 2 |
| Lin, HK; Simon, EJ | 1 |
| Blume, AJ | 1 |
| Biggio, G; Casu, M; Corda, MG; Gessa, GL | 1 |
| Gibson, A; Ginsburg, M; Hall, M; Hart, SL | 1 |
| Kosterlitz, HW; Leslie, FM | 1 |
| Bhargava, HN | 1 |
| Chance, WT; Krynock, GM; Rosecrans, JA; White, AC | 1 |
| Costa, E; Fratta, W; Hong, J; Yang, HY | 1 |
| Berti, F; Bruno, F; Omini, C; Racagni, G | 1 |
| Berggren, A; Rubenson, A; Sillén, U | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M; Mantelet, S; Mauborgne, A | 1 |
| Di Giulio, AM; Donadoni, ML; Finco, C; Germani, E; Gorio, A; Malosio, ML; Mantegazza, P; Tenconi, B | 1 |
| Bowen, WD; Farmer, SC; Mattia, A; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 6 |
| Akami, T; Arakawa, K; Matsumoto, S; Mitsuo, M; Nagase, H; Nakai, I; Nakajima, H; Oka, T; Okamoto, M | 1 |
| Pinnock, RD | 2 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Kane, K; McIntosh, M; Parratt, J | 1 |
| Giles, A; Landymore, KM; Wilkinson, M | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 2 |
| Tang, RR; Tseng, LF | 1 |
| Cheng, PY; Cheng, Y; Decena, J; McCabe, S; Szeto, HH; Wu, DL | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 3 |
| De Vries, TJ; Hogenboom, F; Hruby, VJ; Mulder, AH; Portoghese, PS; Schoffelmeer, AN | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Crook, TJ; Hill, RG; Kitchen, I | 1 |
| Billings, B; Candido, J; Duttaroy, A; Yoburn, BC | 1 |
| Cabral, JD; Leedham, JA; Monroe, PJ; Robertson, B; Smith, DJ; Taylor, DA | 1 |
| Herz, A; Shippenberg, TS; Spanagel, R | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE | 1 |
| Adler, MW; Geller, EB; Handler, CM | 1 |
| Franklin, TG; Traynor, JR | 1 |
| Bakich, V; Law, S; McIntosh, CH | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY | 1 |
| Bowen, WD; Jiang, Q; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Portoghese, PS | 1 |
| Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP | 1 |
| Kavaliers, M; Teskey, GC | 1 |
| Abdelhamid, EE; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Chalmers, J; Drolet, G; Morilak, DA | 2 |
| Mjanger, E; Yaksh, TL | 1 |
| Kaneto, H; Kawasaki, K; Kobayashi, Y; Maeda, M; Shimokawa, K; Taguchi, T; Takahashi, M; Tokuyama, S; Watanabe, J; Yamamoto, Y | 1 |
| Chang, SC; Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Hoffman, DC; West, TE; Wise, RA | 1 |
| Medzihradsky, F; Remmers, AE | 1 |
| Collins, JG; Kitahata, LM; Nakatani, K; Omote, K | 1 |
| Bilotta, JM; Brackeen, MF; Feldman, PL; James, MK; Leighton, HJ; Schuster, SV | 1 |
| de Costa, BR; Drower, EJ; Hammond, DL; Rafferty, MF; Rice, KC; Stapelfeld, A | 1 |
| Jessop, JJ; Taplits, MS | 1 |
| Billington, CJ; Grace, M; Levine, AS | 1 |
| Lu, CL; Shaikh, MB; Siegel, A | 1 |
| Cowan, A; Li, SX; Liu-Chen, LY; Wheeler-Aceto, H | 1 |
| Adams, JU; Holtzman, SG | 1 |
| Butler, B; Gunion, MW; Miller, S; Moore, RD; Morley, JE; Rosenthal, MJ; Zib, B | 1 |
| Shiotsu, G; Stein, L; Stevens, KE | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Cohen, Y; Jacquot, C; Orosco, M; Robert, JJ; Rouch, C | 1 |
| Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL | 1 |
| Duckles, SP; Li, YJ | 1 |
| Kromer, W | 2 |
| Burks, TF; Davis, TP; Greene, DL; Hersh, LB; Hruby, VJ; Kramer, TH; Sharma, SD; Weber, SJ; Yamamura, HI | 1 |
| Fischbach, PS; McCleskey, EW; Schroeder, JE; Zheng, D | 1 |
| Baamonde, A; Daugé, V; Gacel, G; Roques, BP | 1 |
| Pasternak, GW; Paul, D; Pick, CG | 1 |
| Jin, CB; Rockhold, RW | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 2 |
| Billington, CJ; Grace, M; Levine, AS; Portoghese, PS | 1 |
| Allen, JT; Brostrom, PA; DeHaven-Hudkins, DL; Ferkany, JW; Kaplita, PV; Lesko, LJ; Mavunkel, BJ; Rzeszotarski, WJ; Steranka, LR | 1 |
| Lawrence, AJ; Traynor, JR | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A | 1 |
| Birch, PJ; Hayes, AG; Lawrence, AJ; Rogers, H; Traynor, JR | 1 |
| Dixon, DM; Traynor, JR | 1 |
| Calcagnetti, DJ; Holtzman, SG | 1 |
| Höllt, V; Simantov, R | 1 |
| Froimowitz, M | 1 |
| Cone, EJ; Johnson, RE; Su, TP; Vaupel, DB | 1 |
| Klein, P; Nelson, WL; Olsen, LD; Simon, EJ; Yao, YH | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY; Rohrbach, KW | 1 |
| Suh, HH; Tseng, LF | 1 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Chalmers, J; Drolet, G; Morilak, D | 1 |
| Fuentes, JA; Iglesias, T; Jiménez, I | 1 |
| Mosberg, HI; Porreca, F; Qi, JA | 1 |
| Medzihradsky, F; Nordby, GL; Remmers, AE | 1 |
| Herz, A; Parsons, CG | 1 |
| Delle, M; Hoffmann, P; Thorén, P | 1 |
| Ayres, EA; Burks, TF; Davis, P | 1 |
| Lutfy, K; Sierra, V; Yoburn, BC | 2 |
| Cowan, A; Murray, CW | 1 |
| Akil, H; Trujillo, KA | 1 |
| Kessler, JA; Tempel, A; Zukin, RS | 1 |
| Goodman, RR; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Galetta, S; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Costa, E; Mocchetti, I; Ritter, A | 1 |
| Clark, MJ; Medzihradsky, F; Nordby, GL | 1 |
| Echevarria, E; Holaday, JW; Lipkowski, AW; Portoghese, PS; Takemori, AE; Tortella, FC | 1 |
| McLaughlin, PJ; Zagon, IS | 3 |
| Brady, LS; Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 1 |
| Bardo, MT; Neisewander, JL; Nonneman, AJ; Rowlett, JK | 1 |
| Buckingham, JC; Cover, PO | 1 |
| Kanda, A; Kimura, T; Koyanagawa, H; Musha, T; Satoh, S | 1 |
| Hruby, VJ; Knapp, RJ; Toth, G; Vaughn, LK; Wan, YP; Yamamura, HI | 1 |
| Chavkin, C; Opheim, KE; Wimpey, TL | 1 |
| Coscia, CJ; Laskowski, MB; Moudy, AM | 1 |
| Dickenson, AH; Roques, BP; Sullivan, AF | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Gioannini, TL; Hiller, JM; Liu, YF; Park, YH; Simon, EJ | 1 |
| Garzón, J; Sánchez-Blázquez, P | 2 |
| Huidobro-Toro, JP; Li, CH; Valenzuela, R | 1 |
| Bals-Kubik, R; Herz, A; Shippenberg, TS | 1 |
| Garzón, J; Sánchez-Blázquez, P; Ulibarri, I | 1 |
| Pasternak, GW; Recht, LD | 1 |
| Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F | 1 |
| Christie, MJ; North, RA; Williams, JT | 1 |
| Kunos, G; Mosqueda-Garcia, R | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Lessor, RA; McLean, S; Rice, KC; Rothman, RB | 1 |
| Smith, CB | 1 |
| Burks, TF; Fox, DA | 1 |
| Larson, DL; Lipkowski, AW; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Bhargava, HN; Rapaka, RS; Renugopalakrishnan, V | 1 |
| Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Cox, BM; Frattali, A; Portoghese, PS; Takemori, AE; Werling, LL | 1 |
| Herz, A; Höllt, V; Morris, BJ | 1 |
| Inturrisi, CE; Luke, MC; Pasternak, GW; Yoburn, BC | 1 |
| Costa, T; Herz, A; Klinz, FJ; Vachon, L | 1 |
| Dougall, IG; Leff, P | 1 |
| Landymore, KM; Wilkinson, M | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 2 |
| Griffin, JF; Smith, GD | 1 |
| Katoh, M; Kimura, T; Satoh, S | 1 |
| Baskin, DS; Hosobuchi, Y; Kuroda, H; Lee, NM | 1 |
| Di Chiara, G; Morelli, M | 1 |
| Ding, XZ; Fan, SG; Han, JS | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Gosnell, BA; Grace, M; Levine, AS | 1 |
| McLean, S; Rothman, RB | 1 |
| Baratti, CM; Introini, IB; McGaugh, JL | 1 |
| Eskay, R; Kunos, G; Mosqueda-Garcia, R; Palkovits, M; Zamir, N | 1 |
| Koenig, JI; Krulich, L; Moss, RL; Wiesner, JB | 1 |
| Portoghese, PS; Takemori, AE | 4 |
| Cohen, AH; Goodman, RR; Inturrisi, CE; Pasternak, GW; Yoburn, BC | 1 |
| Holaday, JW; Robles, L; Tortella, FC | 1 |
| Gioannini, T; Hui, KS; Hui, M; Lajtha, A; Simon, EJ | 1 |
| Jackson, HC; Sewell, RD | 2 |
| Laubie, M; Schmitt, H | 1 |
| Bell, RD; Cicero, TJ | 1 |
| Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW | 1 |
| Mayer, DJ; Watkins, LR | 1 |
| Holtzman, SG; Locke, KW | 2 |
| Adler, B; Inturrisi, CE; Nunes, FA; Pasternak, GW; Yoburn, BC | 1 |
| Liu-Chen, LY; Tam, SW | 1 |
| Bhargava, HN; Das, S | 2 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Carter, A; Smith, CF | 1 |
| Portoghese, PS; Schoenecker, JW; Takemori, AE | 1 |
| Coscia, CJ; Spain, JW | 1 |
| Cavicchini, E; Ferri, S; Murari, G; Romualdi, P; Speroni, E | 1 |
| Bruzzone, ME; Marusic, ET | 1 |
| Haddad, GG; Jeng, HJ; Lai, TL | 1 |
| Kavaliers, M | 1 |
| Abhold, R; Kalivas, PW | 1 |
| Elsworth, JD; Redmond, DE; Roth, RH | 1 |
| Asdourian, D; Geula, C | 1 |
| Pert, CB; Rothman, RB; Schumacher, UK | 1 |
| Cicero, TJ; Isenberg, KE | 1 |
| Holaday, JW; Tortella, FC | 1 |
| Bernardini, GL; Clark, WG; Pang, IH | 1 |
| Bennett-Kelly, L; Smith, CB; Woods, JH | 1 |
| Kosterlitz, HW; Lord, JA; Paterson, SJ; Waterfield, AA | 1 |
| Bajusz, S; Berzétei, IP; Rónai, AZ; Székely, JI | 1 |
| Ho, AK; Rossi, N | 1 |
| Takemori, AE; Ward, SJ | 2 |
| Chavkin, C; Cox, BM | 1 |
| Fischli, W; Goldstein, A; James, IF | 1 |
| Herz, A; Schulz, R; Wüster, M | 1 |
| Bakharev, VD; Tikhomirov, SM | 1 |
| Giles, T; Merz, H; Sander, G | 1 |
| Simon, EJ; Smith, JR | 1 |
| Clemens, JA; Shaar, CJ | 1 |
| Fratta, W; Grandison, L; Guidotti, A | 1 |
| Bell, JA; Berry, JN; Sharpe, LG | 1 |
| Kosterlitz, HW | 1 |
| Chavkin, C; Goldstein, A | 1 |
| Carrasco, MA; Dias, RD; Elisabetsky, E; Izquierdo, I; Perry, ML; Souza, DO | 1 |
| Byrne, WL; Codd, EE | 1 |
| Kosterlitz, HW; Paterson, SJ; Robson, LE | 1 |
| Blume, AJ; Fantozzi, R; Mullikin-Kilpatrick, D | 1 |
| Clark, WG | 1 |
| Fitz-Syage, ML; Gardner, EL; Gintzler, AR; Sugarman, JR; Zukin, RS; Zukin, SR | 1 |
| Nof, A; Sarne, Y; Urca, G; Weissman, BA | 1 |
| Kameyama, T; Ukai, M | 1 |
| Belenky, GL; Gelinas-Sorell, D; Holaday, JW; Kenner, JR | 1 |
| D'Amato, RJ; Holaday, JW | 1 |
| Cowan, A; Holaday, JW; Robles, LE; Tortella, FC | 1 |
| D'Amato, R; Holaday, JW | 1 |
| Koenig, JI; Krulich, L; Mayfield, MA; McCann, SM | 1 |
| Castellano, C; Csányl, V; Dóka, A; Oliverio, A; Puglisi-Allegra, S | 1 |
| Cooper, SJ | 2 |
| Jhamandas, K; Sutak, M | 1 |
| Lewis, JW; Liebeskind, JC; Sherman, JE; Tordoff, MG | 1 |
| Deen, K; Keil, LC; Severs, WB; Summy-Long, JY | 1 |
| Olds, ME; Williams, KN | 1 |
| Medzihradsky, F; Yabaluri, N | 2 |
| Laorden, ML; Llobell, F | 1 |
| Fukuda, K; Fukushima, N; Misu, Y; Miyamae, T; Sasaki, Y; Takeshima, H; Ueda, H | 1 |
| Carr, DB; Dorociak, A; Gumulka, SW; Lipkowski, AW; Maszczynska, I; Misterek, K; Szyfelbein, SK | 1 |
| Fukushima, N; Hayashi, C; Katayama, T; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Armstead, WM | 2 |
| Imai, Y; Schäfer, M; Stein, C; Uhl, GR | 1 |
| Hammond, DL; Littell, L; Stewart, PE | 1 |
| Goodman, M; Malmberg, AB; Ro, S; Schiller, P; Yaksh, TL | 1 |
| Fujinami, T; Nishimura, M; Saeki, T; Sato, N; Watanabe, Y | 1 |
| Gong, QZ; Hamm, RJ; Jiang, JY; Lyeth, BG; Young, HF | 1 |
| Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
| Endoh, T; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 2 |
| Knapp, RJ; Li, X; Malatynska, E; Roeske, WR; Santoro, G; Waite, S; Wang, Y; Yamamura, HI | 1 |
| Chen, C; Chen, YW; Kim de Riel, J; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Alsasua, A; Martín, MI; Parra, L; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M; Saitoh, A; Suzuki, T | 1 |
| Tripathi, A; Welch, SP | 1 |
| Shahabi, NA; Sharp, BM | 1 |
| Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Petit, A | 1 |
| Kushner, L; Tamir, M | 1 |
| Devine, DP; Leone, P; Pocock, D; Wise, RA | 1 |
| Gianoulakis, C | 1 |
| Lai, J; Porreca, F; Vanderah, TW; Yamamura, HI | 1 |
| Coupar, IM; Hancock, DL | 1 |
| Randić, M; Wang, RA | 1 |
| Kradel, BK; Monroe, PJ; Smith, DJ; Smith, DL | 1 |
| Crisp, T; Keck, BJ; Stafinsky, JL; Uram, M | 1 |
| Jourd'Heuil, D; Lang, ME; Meddings, JB; Swain, MG | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Corringer, PJ; Dauge, V; Roques, BP | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Noble, F; Roques, BP | 1 |
| Donatini, A; Ferri, S; Lesa, G; Romualdi, P | 1 |
| Coenen, A; Lasoń, W; Machelska, H; Przewłocka, B; Przewłocki, R; van Luijtelaar, G | 1 |
| Adams, JU; Li, S; Liu-Chen, LY; Yang, HH | 1 |
| Elliott, J; Lambert, DG; Smart, D; Traynor, JR | 2 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Almeida, OF; Shippenberg, TS; Spanagel, R | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Kamei, J; Misawa, M; Mizoguchi, H; Nagase, H; Suzuki, T; Yoshiike, M | 1 |
| Gewiss, M; Goldberg, SR; Marley, RJ; Schindler, CW; Shimosato, K; Thorndike, E | 1 |
| Cheng, PY; Soong, Y; Szeto, HH; Wu, DL | 1 |
| Dworkin, SI; Martin, TJ; Smith, JE | 2 |
| Ingenito, AJ; Wong, SC | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Connelly, CD; Martinez, RP; Porreca, F; Raffa, RB; Schupsky, JJ | 1 |
| Guirimand, F; Le Bars, D; Strimbu-Gozariu, M; Willer, JC | 1 |
| Sheiner, LB; Troconiz, IF; Verotta, D | 1 |
| Buéno, L; Gué, M; Junien, JL | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Kameyama, T; Mizutani, M; Ukai, M | 1 |
| Kameyama, T; Mizutani, M; Sasaki, Y; Toyoshi, T; Ukai, M | 1 |
| Rafferty, MF; Tam, L | 1 |
| Burke, TF; Lewis, JW; Medzihradsky, F; Woods, JH | 1 |
| Davis, T; Shah, S; Yoburn, BC | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Kwok, YN; McIntosh, C; Yago, V | 1 |
| Kim, YH; Lim, JS; Song, DK; Suh, HW; Tseng, LF | 1 |
| Noble, F; Roques, BP; Smadja, C | 1 |
| Crook, TJ; Hill, RG; Kitchen, I; Muhammad, BY | 1 |
| Boersma, CJ; Pool, CW; Van Heerikhuize, JJ; Van Leeuwen, FW | 1 |
| Bhargava, HN; Matwyshyn, GA; Reddy, PL; Thorat, SN | 1 |
| Eisenberg, RM | 2 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 1 |
| Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H | 1 |
| Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Venier, I | 1 |
| Callahan, P; Janik, J; Klosterman, S; Parman, R | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Cai, YP; Yu, LC | 2 |
| Adloff, M; Angel, F; Chamouard, P; Klein, A; Martin, E | 1 |
| Bhargava, HN; Matwyshyn, GA; Reddy, PL | 1 |
| D'Alecy, LG; Mayfield, KP | 1 |
| Hammond, DL; Stewart, PE | 2 |
| Fang, L; Haaseth, RC; Horvath, R; Hruby, VJ; Knapp, RJ; Matsunaga, TO; Porreca, F; Yamamura, HI | 1 |
| Ahmed, MS; Cemerikic, B; Zamah, R | 1 |
| Maier, SF; Mooney-Heiberger, K; Watkins, LR; Wiertelak, EP; Yang, HY | 1 |
| Martin, BR; Smith, PB; Welch, SP | 1 |
| Ludbrook, J; Ventura, S | 1 |
| Hirokami, M; Ikeda, T; Matsumoto, M; Saito, H; Smith, CB; Tochihara, M; Togashi, H; Yoshioka, M | 1 |
| Haaseth, RC; Hruby, VJ; Matsunaga, TO; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Vanderah, T | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Babin, E; Fang, L; Hruby, VJ; Knapp, RJ; Li, X; Malatynska, E; Nguyen, M; Roeske, WR; Santoro, G; Varga, EV | 1 |
| Colwell, DD; Kavaliers, M | 1 |
| Fukushima, N; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Mulder, AH; Ronken, E; Schoffelmeer, AN | 1 |
| Côté, TE; Izenwasser, S; Weems, HB | 1 |
| Chang, KJ; Comer, SD; De Costa, BR; McNutt, RW; Mosberg, HI; Woods, JH | 1 |
| Chang, KJ; Comer, SD; De Costa, BR; Hoenicke, EM; McNutt, RW; Mosberg, HI; Sable, AI; Woods, JH | 1 |
| Chakrabarti, S; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Mokhtari, M; Tafani, JA; Zajac, JM | 1 |
| Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 1 |
| Durham, RA; Lookingland, KJ; Manzanares, J; Moore, KE | 1 |
| Búzás, B; Cox, BM; Izenwasser, S; Portoghese, PS | 1 |
| Innes, DG; Kavaliers, M | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H | 1 |
| DeHaven-Hudkins, DL; Komer, KM; Mavunkel, BJ; Peterson, JA; Rzeszotarski, WJ | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Dosaka-Akita, K; Holaday, JW; Long, JB; Tortella, FC | 1 |
| Bowen, WD; Carlisi, VJ; Hruby, VJ; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Wild, KD | 1 |
| Kameyama, T; Mori, E; Ukai, M | 1 |
| Miyamoto, Y; Portoghese, PS; Takemori, AE | 2 |
| Carter, BD; Medzihradsky, F | 1 |
| Mosberg, HI; Porreca, F; Raffa, RB; Wild, KD | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Collins, KA; Portoghese, PS; Tseng, LF | 1 |
| Welch, SP | 1 |
| De Vries, TJ; Mulder, AH; Schoffelmeer, AN; Tjon Tien Ril, GH; Van der Laan, JW | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Desmeules, JA; Gacel, G; Guilbaud, G; Kayser, V; Roques, BP | 1 |
| Matsumoto, M; Saito, H; Smith, CB; Togashi, H; Yoshioka, M | 1 |
| Desmeules, JA; Guilbaud, G; Kayser, V | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Lazar, DF; Medzihradsky, F | 1 |
| Cheng, PY; Decena, JA; McCabe, S; Soong, Y; Szeto, HH; Wu, D | 1 |
| Adams, JU; Adler, MW; Geller, EB; Tallarida, RJ | 1 |
| Ho, IK; Hoskins, B; Jaw, SP | 1 |
| Callahan, P; Janik, J; Kehoe, L; Parman, R | 1 |
| Magyar, A; Medzihradszky, K; Rónai, AZ | 1 |
| Cowan, A; Hunter, JC; Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Wheeler-Aceto, H | 1 |
| Blakely, RD; Cohen, SM; Domin, B; Fremeau, RT; Henzi, VA; Miller, JW; Nadler, JV; Shafqat, S; Velaz-Faircloth, M | 1 |
| Howard, BA; Wilson, JR | 1 |
| Imai, Y; Kreek, MJ; Rubenfeld, JM; Uhl, GR; Unterwald, EM; Wang, JB | 1 |
| Potter, DE; Wang, D | 1 |
| Davenport, KE; Houdi, AA; Marson, L; Van Loon, GR | 1 |
| Honkanen, A; Hyytiä, P; Korpi, ER; Sarviharju, M; Vilamo, L; Wegelius, K | 1 |
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| Chen, SF; Ghanta, VK; Hiramoto, RN; Hsueh, CM; Huang, HJ | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Kübler, W; Mura, RA; Niroomand, F; Piacentini, L | 1 |
| Bates, SL; Davison, JS; Lang, ME; Meddings, JB | 1 |
| Mokha, SS; Wang, XM; Yan, JQ; Zhang, KM | 1 |
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| Chen, HS; Hu, DY; Liu, LM; Lu, RQ; Yan, W | 1 |
| Grupp, LA; Harding, S; Szczepanska, R | 1 |
| Fujimoto, J; Ho, BY; Holmes, BB; Zhao, J | 1 |
| Cai, YC; Cheng, ZJ; Fan, GH; Jiang, LZ; Ma, L; Pei, G | 1 |
| Nelson, WL; Palmer, RB; Upthagrove, AL | 1 |
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| Breivogel, CS; Childers, SR; Selley, DE | 1 |
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| Bombelli, R; Cosentino, M; Ferrari, M; Frigo, G; Giaroni, C; Lecchini, S; Marino, F; Rasini, E | 1 |
| Chao, CC; Gekker, G; Hu, S; Lipovsky, MM; Molitor, TW; Peterson, PK; Sowa, G | 1 |
| Khan, S; Smith, ME | 1 |
| Billington, CJ; Kotz, CM; Levine, AS | 1 |
| Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV | 1 |
| DiGiacomo, B; Larson, DL; Ohkawa, S; Portoghese, PS; Takemori, AE | 1 |
| Burkey, TH; Hosohata, K; Hosohata, Y; Hruby, VJ; Knapp, RJ; Nagase, H; Porreca, F; Quock, RM; Rice, KC; Roeske, WR; Yamamura, HI; Zhang, X | 1 |
| Bauer, L; Bhargava, HN; Bian, JT; Dunn, WJ; Nan, Y; Upadhyaya, SP; Xu, W; Zhao, GM | 1 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Kramer, TH; Porreca, F | 1 |
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| Bodnar, RJ; Leventhal, L; Pasternak, GW; Rossi, GC; Stevens, LB | 1 |
| Childers, SR; deMontis, MG; Martin, TJ; Selley, DE; Sim, LJ | 1 |
| Childers, SR; Sim, LJ | 1 |
| Hammond, DL; Thorat, SN | 1 |
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| Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
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| Appleyard, SM; Davis, TP; Hruby, VJ; Knapp, RJ; Lipkowski, AW; Misicka, A; Slaninova, J; Weber, SJ; Yamamura, HI | 1 |
| Miller, RJ; Simen, AA | 1 |
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| Butelman, ER; Ko, MC; Traynor, JR; Woods, JH | 1 |
| Gosnell, BA; Kelley, AE; Zhang, M | 1 |
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| Butelman, ER; Ko, MC; Woods, JH | 1 |
| Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G | 1 |
| Gilbert-Rahola, J; Maldonado, R; Micó, JA; Roques, BP; Smadja, C; Tejedor-Real, P | 1 |
| Lysle, DT; Schneider, GM | 1 |
| Billington, CJ; Giraudo, SQ; Kotz, CM; Levine, AS | 1 |
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| Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB | 1 |
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| Becker, A; Grecksch, G; Hoellt, V; Schroeder, H; Schroeder, U | 1 |
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| Kowalski, J | 1 |
| Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T | 1 |
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| Clark, MJ; Emmerson, PJ; Medzihradsky, F; Remmers, AE | 1 |
| Carroll, J; Chen, B; Duttaroy, A; Sehba, F; Shah, S; Shen, J; Yoburn, BC | 1 |
| Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L; SanMartín, S | 1 |
| McGinty, JF; Rawls, SM; Terrian, DM | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| McLaughlin, PJ; Wu, Y; Zagon, IS | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Cui, RY; Jiang, CL; Liu, XY; Lu, CL; Son, LX; Sun, LY; Wang, YX; You, ZD | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
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| Freeman, FM; Young, IG | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Miletić, T; Radulović, J; Stanojević, S; Vujić-Redzić, V | 1 |
| Brown, DR; Poonyachoti, S; Portoghese, PS | 1 |
| Hammond, DL; Hurley, RW | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ; Tseng, LF | 1 |
| Fink, DJ; Glorioso, JC; Goins, WF; Goss, JR; Mata, M; Wu, HH | 1 |
| Li, P; Longhurst, JC; Tjen-A-Looi, S | 1 |
| Cowen, MS; Lawrence, AJ | 1 |
| Agashe, GS; Clark, JD; Davies, MF; Kingery, WS; Sawamura, S; Zimmer, A | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE | 1 |
| Hung, KC; Mizoguchi, H; Nagase, H; Tseng, LF; Wu, HE | 1 |
| Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB | 1 |
| Bhalla, S; Bouvier, M; Hogue, M; Laperrière, A; Morello, JP; Petäjä-Repo, UE | 1 |
| Deschamps, JR; Flippen-Anderson, JL; George, C; Hruby, VJ; Lipkowski, AW; Misicka, A | 1 |
| Fiore, P; Gannon, RL; Tierno, A | 1 |
| Gallo, RV; Zhang, Q | 1 |
| Chen, J; Duman, RS; Nestler, EJ; Neve, R; Newton, SS; Sakai, N; Schlesinger, L; Shirayama, Y; Thome, J; Wallace, TL | 1 |
| Chavkin, C; Marton-Popovici, M; McLaughlin, JP | 1 |
| Grillo, CA; Lucas, LR; McEwen, BS | 1 |
| Barlow, M; Caffrey, JL; Deo, S; Farias, M; Jackson, K; Johnson, S; Stanfill, AA | 1 |
| Guth, AN; Holmes, PV; Lelutiu, NB; Primeaux, SD; Wilson, MA; Wilson, SP | 1 |
| Brailoiu, GC; Dun, NJ; Ohtubo, Y; Wu, SY | 1 |
| McLaughlin, PJ; Verderame, MF; Zagon, IS | 1 |
| Jones, T; Laurito, CE; Lu, Y; Wilson, SP; Yeomans, DC | 1 |
| Fujimoto, JM; Leitermann, RJ; Sun, HS; Thompson, J; Tseng, LF; Wu, HE | 1 |
| Cox, ML; Welch, SP | 1 |
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| Befort, K; Décaillot, FM; Filliol, D; Kieffer, BL; Lazarus, LH; Schiller, PW; Schmidhammer, H; Tryoen-Tóth, P | 1 |
| Bespalova, ZhD; Lasukova, TV; Maslov, LN; Nagase, H; Oldgen, P; Rice, KK | 1 |
| Dziwinski, T; Majewski, P; Pawlak, J; Skwarlo-Sonta, K; Waloch, M | 1 |
| Bourgoin, S; Glowinski, J; Godeheu, G; Jabourian, M; Kemel, ML; Ozon, S; Pérez, S; Venance, L | 1 |
| Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K | 1 |
| Guen, SL; Kieffer, BL; Nieto, MM; Noble, F; Roques, BP | 1 |
| Chavkin, C; Chavkin, TA; Li, S; McLaughlin, JP; Valdez, J | 1 |
| Handa, H; Hasegawa, M; Hatakeyama, M; Kawaguchi, H; Ohno, H; Takahashi, T; Tanaka, H | 1 |
| Dan, FJ; Hu, DY; Liu, LM; Lu, RQ; Pan, XK | 1 |
| Bakalkin, G; Kuzmin, A; Madjid, N; Ogren, SO; Terenius, L | 1 |
| Maldonado, R; Mendizábal, V; Zimmer, A | 1 |
| Kamei, J; Miyata, S; Saitoh, A; Takahashi, M | 1 |
| Farrell, PA; Loomis, JL; Rodd, DW | 1 |
| Buxbaum, JD; Cho, J; Jacobson, DA; Landa, LR; Philipson, LH; Roe, MW; Tamarina, NA | 1 |
| Mascagni, F; McDonald, AJ; Primeaux, SD; Wilson, MA; Wilson, SP | 1 |
| Pierzchała-Koziec, K; Rzasa, J; Zubel, J | 1 |
| Herzog, H; Loacker, S; Sayyah, M; Schwarzer, C; Wittmann, W | 1 |
| Eriksson, S; Frithiof, R; Rundgren, M | 1 |
| Alloui, A; Baron, A; Blondeau, N; Cupo, A; Diochot, S; Eschalier, A; Escoubas, P; Gélot, A; Heurteaux, C; Lazdunski, M; Mazzuca, M; Voilley, N; Zimmer, A; Zimmer, AM | 1 |
| Burger, MC; Cramb, DT; Dahms, TE; Massotte, D; Swift, JL | 1 |
| Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A | 1 |
| Chavkin, C; Gendron, L; Pintar, JE | 1 |
| Bonney, I; Carr, DB; Klinowiecka, A; Kosson, D; Kosson, P; Lipkowski, AW; Mayzner-Zawadzka, E | 1 |
| Bruchas, MR; Chavkin, C; Land, BB; Lemos, JC; Melief, EJ; Xu, M | 1 |
| Virk, MS; Williams, JT | 1 |
| Caffrey, JL; Guyton, RA; Jiang, R; Kin, H; Mykytenko, J; Reeves, JG; Vinten-Johansen, J; Wang, N; Yoshishige, D; Zatta, AJ; Zhao, ZQ | 1 |
| Gaburro, S; Herzog, H; Rosskothen, I; Schunk, E; Schwarzer, C; Singewald, N; Wittmann, W | 1 |
| Chen, YS; Huang, HS; Lee, YJ; Ma, MC; Peng, PH | 1 |
| Charron, C; Hakim, AM; Plamondon, H; Proulx, G; Schock, SC; Thompson, CS | 1 |
| Carey, AN; Dunton, O; Lyons, AM; McLaughlin, JP; Shay, CF | 1 |
| Rai, U; Singh, R | 1 |
| Belkaï, E; Marie-Claire, C; Noble, F; Scherrmann, JM | 1 |
| Cline, MA; Hiramatsu, K; Sugahara, K; Tachibana, T; Ueda, H | 1 |
| Bing, G; Jang, CG; Kim, HC; Koo, KH; Nabeshima, T; Oh, CH; Oh, KW; Park, DH; Shin, EJ; Yamada, K | 1 |
| Di Paolo, T; Grégoire, L; Lévesque, D; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P; Tamim, MK | 1 |
| Bishop, VR; Brown, CH; Leng, G; Scott, V | 1 |
| Gieryk, A; Kubik, J; Przewlocki, R; Solecki, W; Ziolkowska, B | 1 |
| Carey, AN; Gomes, SM; McLaughlin, JP; Sperling, RE; Sypek, EI | 1 |
| Balleine, BW; Cely, IC; Maidment, NT; Wassum, KM | 1 |
| Bagosi, Z; Csabafi, K; Jászberényi, M; Telegdy, G; Tóth, G; Wollemann, M | 1 |
| Donahue, RN; McLaughlin, PJ; Zagon, IS | 2 |
| Beresewicz, M; Kawalec, M; Kowalczyk, JE; Lipkowski, AW; Zablocka, B | 1 |
| Hamid, A; Lutfy, K; Marquez, P; Nguyen, K; Tseng, A | 1 |
| Lipkowski, AW; Szereda-Przestaszewska, M; Wojciechowski, P | 1 |
| Chai, W; Gao, CJ; Li, YQ; Niu, L; Ren, PC; Sun, XD; Wang, W; Zhu, C | 1 |
| Dunlop, SA; Farid, WO; Hulse, GK; Krstew, EV; Lawrence, AJ; Tait, RJ | 1 |
| Bilsky, EJ; Cain, JP; Hruby, VJ; Hu, J; Kumirov, VK; Lee, YS; Podolsky, AT; Sandweiss, A; Vanderah, TW; Vardanyan, RS | 1 |
| Bilkei-Gorzo, A; Mauer, D; Michel, K; Zimmer, A | 1 |
| Crawford, EF; George, O; Koob, GF; Park, PE; Schlosburg, JE; Vendruscolo, LF; Whitfield, TW | 1 |
| Katsuyama, S; Komatsu, T; Mizoguchi, H; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M | 1 |
| Williams, JT | 1 |
| Dehe, L; Feldheiser, A; Habazettl, H; Mousa, SA; Röpke, TK; Schäfer, M; Shakibaei, M; Shaqura, M; Spies, CD; Treskatsch, S | 1 |
| Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Marszalek-Grabska, M; Witkowska, E | 1 |
| Crawford, E; Edwards, S; George, O; Gould, A; Grant, Y; Koob, GF; Schlosburg, JE; Vendruscolo, LF; Wee, S; Whitfield, TW; Zamora-Martinez, ER | 1 |
| Booth, FW; Ruegsegger, GN; Toedebusch, RG; Will, MJ | 1 |
| Fujii, H; Higashi, E; Hirayama, S; Iihara, Y; Iwai, T; Nagase, H; Nemoto, T | 1 |
| Hang, A; Liu, JG; Liu, Y; Shu, XH; Wang, Q; Wang, YJ; Zan, GY | 1 |
| Cieslak, PE; Korostynski, M; Przewlocki, R; Szklarczyk, K; Wawrzczak-Bargiela, A | 1 |
| Lesniak, A; Lipkowski, AW; Misicka, A; Pick, CG; Sacharczuk, M | 1 |
| Katsuyama, S; Komatsu, T; Mizoguchi, H; Nagase, H; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M | 1 |
| Alazzani, M; Alhusban, AY; Alzoubi, KH; Bawaane, A; Khabour, OF; Nuseir, KQ | 1 |
| McLaughlin, PJ; Purushothaman, I; Sassani, JW; Zagon, IS | 1 |
| Graham, DP; Hamon, SC; Hillhouse, M; Kosten, TR; Lawson, WB; Ling, W; Nielsen, DA; Nielsen, EM; Rotrosen, J; Saxon, AJ; Settles-Reaves, BD; Shmueli-Blumberg, D; Shores-Wilson, K; Trivedi, MH; Walker, R | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
8 review(s) available for enkephalin, leucine and naltrexone
| Article | Year |
|---|---|
X-ray diffraction studies of enkephalins and opiates.
Topics: Enkephalins; Molecular Conformation; Naltrexone; Narcotics; Protein Conformation; Receptors, Opioid; X-Ray Diffraction | 1988 |
[Enkephalinergic regulation of cardiovascular centers].
Topics: Animals; Blood Pressure; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Dextromoramide; Dogs; Enkephalin, Methionine; Enkephalins; Heart Rate; Medulla Oblongata; Naloxone; Naltrexone; Nervous System Physiological Phenomena; Pressoreceptors; Rats; Receptors, Opioid; Reflex; Reticular Formation; Sympathetic Nervous System; Vagus Nerve; Vasomotor System | 1985 |
Multiple endogenous opiate and non-opiate analgesia systems: evidence of their existence and clinical implications.
Topics: Acupuncture Therapy; Analgesia; Animals; Cholecystokinin; Conditioning, Classical; Desipramine; Dimethyl Sulfoxide; Drug Interactions; Electroshock; Endorphins; Enkephalin, Leucine; Mecamylamine; Morphine; N-Methylscopolamine; Naloxone; Naltrexone; Norepinephrine; Proglumide; Rats; Receptors, Cell Surface; Receptors, Cholecystokinin; Scopolamine; Scopolamine Derivatives; Serotonin; Spinal Cord | 1986 |
[Neuropeptide role in the etiology, pathogenesis and clinical aspects of mental diseases].
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Depressive Disorder; Drug Therapy, Combination; Endorphins; Enkephalins; Humans; Mental Disorders; Naloxone; Naltrexone; Nerve Tissue Proteins; Pituitary Hormones; Psychotropic Drugs; Schizophrenia; Substance-Related Disorders; Vasopressins | 1984 |
The role of opioid peptides in memory and learning.
Topics: Amnesia; Animals; beta-Endorphin; Brain; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Learning; Memory; Naloxone; Naltrexone; Norepinephrine; Rats | 1980 |
Minireview. Benzodiazepine-opiate antagonist interactions in relation to feeding and drinking behavior.
Topics: Animals; Benzodiazepines; Corpus Striatum; Drinking Behavior; Enkephalins; Feeding Behavior; Food Deprivation; Humans; Hyperphagia; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Reward; Thirst | 1983 |
Endogenous opioids and excessive alcohol consumption.
Topics: Alcohol Drinking; Animals; Brain; Endorphins; Enkephalins; Ethanol; Hypothalamus; In Vitro Techniques; Naltrexone; Pituitary Gland; RNA; Substance-Related Disorders | 1993 |
Ocular surface complications in diabetes: The interrelationship between insulin and enkephalin.
Topics: Animals; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Dry Eye Syndromes; Enkephalins; Humans; Insulin; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 2021 |
3 trial(s) available for enkephalin, leucine and naltrexone
| Article | Year |
|---|---|
Effect of an opiate antagonist on movement disorders.
Topics: Adult; Aged; Clinical Trials as Topic; Enkephalins; Humans; Huntington Disease; Middle Aged; Naloxone; Naltrexone; Parkinson Disease | 1978 |
Influence of opioids in hypothalamic nuclei on cold thermogenesis of lean and obese LA/N-cp rats.
Topics: Animals; Cold Temperature; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity; Opioid Peptides; Oxygen Consumption; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Stress, Physiological; Thermogenesis | 1994 |
Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Enkephalins; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Protein Precursors | 2022 |
547 other study(ies) available for enkephalin, leucine and naltrexone
| Article | Year |
|---|---|
Peptides as receptor selectivity modulators of opiate pharmacophores.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Indicators and Reagents; Kinetics; Oligopeptides; Receptors, Opioid; Structure-Activity Relationship | 1986 |
Narcotic drug discriminations by rhesus monkeys and pigeons.
Topics: Animals; Columbidae; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalins; Ethylketocyclazocine; Etorphine; Hormones; Macaca; Macaca mulatta; Naltrexone; Narcotics; Phenazocine | 1979 |
Behavioural dissociation of the enkephalinergic systems of nucleus accumbens and nucleus caudatus.
Topics: Animals; Brain; Caudate Nucleus; Enkephalins; Globus Pallidus; Male; Morphine; Naloxone; Naltrexone; Olfactory Bulb; Oligopeptides; Rats; Receptors, Opioid; Stereotaxic Techniques | 1977 |
Opioid peptides and opiates differ in receptor selectivity.
Topics: Animals; Brain; Dextrorphan; Endorphins; Enkephalins; Isomerism; Levorphanol; Methadone; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1977 |
Phospholipase A inhibition of opiate receptor binding can be reversed by albumin.
Topics: Animals; Brain; Enkephalins; Etorphine; In Vitro Techniques; Male; Naltrexone; Phospholipases; Rats; Receptors, Opioid; Serum Albumin, Bovine | 1978 |
Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides.
Topics: Animals; Brain; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Ligands; Male; Manganese; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Opioid; Ribonucleotides; Sodium | 1978 |
Decrease of cyclic GMP in cerebellum by intrastriatal D-Ala2-met-enkephalinamide.
Topics: Animals; Catalepsy; Cerebellum; Corpus Striatum; Cyclic GMP; Endorphins; Enkephalins; Humans; Injections; Male; Naltrexone; Rats | 1978 |
The effect of intracerebroventricular administration of methionine-enkephalin on the stress-induced secretion of corticosterone in mice.
Topics: Animals; Corticosterone; Endorphins; Enkephalins; Ether; Kinetics; Male; Mice; Naltrexone; Stress, Physiological | 1979 |
Comparison of binding of [3H]-methionine-enkephalin, [3H]-naltrexone and [3H]-dihydromorphine in the mouse vas deferens and the myenteric plexus and brain of the ginea pig.
Topics: Animals; Brain; Dihydromorphine; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine Derivatives; Myenteric Plexus; Naloxone; Naltrexone; Organ Specificity; Stereoisomerism; Vas Deferens | 1979 |
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine | 1979 |
Autoanalgesia: acquisition, blockade and relationship to opiate binding.
Topics: Analgesia; Animals; Brain; Conditioning, Classical; Diazepam; Enkephalins; Etorphine; In Vitro Techniques; Male; Naltrexone; Narcotics; Rats; Reaction Time; Spinal Cord | 1979 |
Stability of Met-enkephalin content in brain structures of morphine-dependent or foot shock-stressed rats.
Topics: Animals; Brain; Corpus Striatum; Enkephalins; Humans; Hypothalamus; Male; Morphine Dependence; Naltrexone; Oligopeptides; Rats; Stress, Psychological; Substance Withdrawal Syndrome | 1977 |
Genotype dependent response of morphine and methionine-enkephalin on the electrically induced contractions of the mouse vas deferens.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Vas Deferens | 1978 |
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics | 1992 |
Kappa-/mu-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Male; Models, Neurological; Naloxone; Naltrexone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 1992 |
Perinatal morphine exposure alters peptidergic development in the striatum.
Topics: Animals; Blotting, Northern; Body Weight; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Growth; Immunohistochemistry; In Situ Hybridization; Morphine; Naloxone; Naltrexone; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P | 1992 |
Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype.
Topics: Affinity Labels; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Spinal Cord; Thiocyanates | 1992 |
Effects of [D-Ala2, D-Leu5]enkephalin and [D-Pen2, L-Pen5]enkephalin on apomorphine-induced motor activity in the mouse.
Topics: Analgesics; Animals; Apomorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Grooming; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1992 |
Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.
Topics: Analgesics; beta-Endorphin; Cell Survival; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; Indoles; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro.
Topics: Amino Acids; Analgesics; Animals; Benzofurans; Benzomorphans; Bicuculline; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Ligands; Locus Coeruleus; Membrane Potentials; Naloxone; Naltrexone; Picrotoxin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Effects of selective opioid receptor agonists and antagonists during myocardial ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Ex vivo determination of opiate antagonist binding at mu-opioid ([3H]-DAGO) receptors in hypothalamic micropunches from maturing female rats: comparison between SDZ 210-096 and nalmefene.
Topics: Age Factors; Animals; Animals, Newborn; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hypothalamus; Morphinans; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation; Vagina | 1992 |
Modulation of kappa-mediated antitussive activity in rats by a delta-agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Cough; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reflex | 1992 |
Pentobarbital attenuates antinociception induced by i.c.v. morphine but not beta-endorphin in the mouse.
Topics: Animals; beta-Endorphin; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pentobarbital; Receptors, Opioid | 1992 |
Central opioid modulation of breathing dynamics in the fetal lamb: effects of [D-Pen2,D-Pen5]-enkephalin and partial antagonism by naltrindole.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetus; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Sheep | 1992 |
delta-Opioid receptor binding in mouse brain: evidence for heterogeneous binding sites.
Topics: Animals; Binding, Competitive; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Membranes; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1992 |
Opioid receptor antagonists discriminate between presynaptic mu and delta receptors and the adenylate cyclase-coupled opioid receptor complex in the brain.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
Chronic d-amphetamine inhibits opioid receptor antagonist-induced supersensitivity.
Topics: Animals; Dextroamphetamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Up-Regulation | 1992 |
Opioid receptors mediating antinociception from beta-endorphin and morphine in the periaqueductal gray.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid | 1992 |
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Infusions, Parenteral; Limbic System; Male; Microinjections; Models, Neurological; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Somatostatin; Tegmentum Mesencephali | 1992 |
Combination of a delta opioid receptor agonist but not a mu opioid receptor agonist with the D1-selective dopamine receptor agonist SKF 38393 markedly potentiates different behaviors in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Grooming; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Motor Activity; Naltrexone; Sulpiride | 1992 |
Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Benzofurans; Bicuculline; Bombesin; Cholecystokinin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Naloxone; Naltrexone; Neurons; Picrotoxin; Prazosin; Pyrrolidines; Quinoxalines; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Synapses; Tetrodotoxin | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Effect of mu-, kappa-, and delta-selective opioid agonists on thermoregulation in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Molecular Sequence Data; Morphinans; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Alkylation with beta-funaltrexamine suggests differences between mu-opioid receptor systems in guinea-pig brain and myenteric-plexus.
Topics: Alkylating Agents; Alkylation; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Naltrexone; Receptors, Opioid, mu | 1991 |
Chronic naltrexone treatment of rats: effects on gastrointestinal opioid peptide content.
Topics: Animals; beta-Endorphin; Digestive System; Duodenum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Jejunum; Male; Naltrexone; Pyloric Antrum; Radioimmunoassay; Radioligand Assay; Rats; Rats, Wistar | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Autoradiographic study of irreversible binding of [3H]beta-funaltrexamine to opioid receptors in the rat forebrain: comparison with mu and delta receptor distribution.
Topics: Animals; Autoradiography; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Telencephalon; Tritium | 1991 |
Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates | 1991 |
An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.
Topics: Amino Acid Sequence; Drug Design; Enkephalins; Indoles; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1991 |
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Modifications of social conflict-induced analgesic and activity responses in male mice receiving chronic opioid agonist and antagonist treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Conflict, Psychological; Enkephalin, Leucine; Infusion Pumps, Implantable; Levorphanol; Male; Mice; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Receptors, Opioid; Social Behavior; Sodium Chloride | 1991 |
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
Topics: Animals; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Isothiocyanates; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates | 1991 |
Endogenous opioids tonically inhibit the depressor neurones in the caudal ventrolateral medulla of rabbits: mediation through delta- and kappa-receptors.
Topics: Amino Acid Sequence; Animals; Endorphins; Enkephalin, Leucine; Hemodynamics; Male; Medulla Oblongata; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1991 |
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil | 1991 |
The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo.
Topics: Analgesics; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Dissociation of opioid receptor upregulation and functional supersensitivity.
Topics: Analgesia; Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naltrexone; Pertussis Toxin; Receptors, Opioid; Up-Regulation; Virulence Factors, Bordetella | 1991 |
Ventral pallidal microinjections of receptor-selective opioid agonists produce differential effects on circling and locomotor activity in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Functional Laterality; Globus Pallidus; Male; Microinjections; Motor Activity; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior; Time Factors | 1991 |
Resolution of biphasic binding of the opioid antagonist naltrexone in brain membranes.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Male; Membranes; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes | 1991 |
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.
Topics: Alkylation; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Vas Deferens | 1991 |
Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Cross-tolerance studies in the spinal cord of beta-FNA-treated mice provides further evidence for delta opioid receptor subtypes.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
In vitro effect of high doses of morphine on Con A induced lymphokine production.
Topics: Animals; beta-Endorphin; Cell Survival; Cells, Cultured; Clone Cells; Colforsin; Concanavalin A; Cyclic AMP; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Enkephalins; Female; Lymphocyte Activation; Lymphokines; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Protein Biosynthesis; Receptors, Opioid; Spleen; T-Lymphocytes, Helper-Inducer | 1991 |
DAGO ([D-Ala2,N-Me-Phe4,Gly-ol]enkephalin) specifically reverses apomorphine-induced increase in rearing and grooming behaviors in the mouse.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Grooming; Injections, Intraventricular; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Beta-funaltrexamine (beta-FNA) decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Feeding Behavior; Food Deprivation; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
An enkephalinergic mechanism involved in amygdaloid suppression of affective defence behavior elicited from the midbrain periaqueductal gray in the cat.
Topics: Affect; Aggression; Amygdala; Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalins; Female; Fluorescent Dyes; Homocysteine; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Stilbamidines | 1991 |
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Time Factors; Tritium | 1991 |
Naltrexone-sensitizing effects of centrally administered morphine and opioid peptides.
Topics: Animals; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
mu-receptor mediates elevated glucose and corticosterone after third ventricle injection of opioid peptides.
Topics: Animals; beta-Endorphin; Blood Glucose; Cerebral Ventricles; Corticosterone; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fatty Acids, Nonesterified; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration | 1991 |
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes | 1991 |
Effects of dexfenfluramine and opioid peptides, alone or in combination, on food intake and brain serotonin turnover in rats.
Topics: Animals; beta-Endorphin; Brain; Drug Interactions; Dynorphins; Eating; Endorphins; Enkephalin, Leucine; Female; Fenfluramine; Naltrexone; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1991 |
Effect of opioid receptor antagonists on vasodilator nerve actions in the perfused rat mesentery.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanethidine; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Vasodilation | 1991 |
[D-Ala2,NMePhe4,Gly-ol5]enkephalin, but not [D-Pen2,L-Pen5]enkephalin, specifically inhibits behaviors induced by the dopamine D2 agonist RU 24213.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Motor Activity; Naltrexone; Phenethylamines | 1991 |
Voltage-clamp experiments reveal receptor type-dependent modulation of chloride secretion in the guinea pig colonic mucosa by intestinal opioids.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alprostadil; Amiloride; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gluconates; Guinea Pigs; Intestinal Mucosa; Male; Membrane Potentials; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin; Theophylline | 1991 |
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
Topics: Analgesics; Animals; Binding, Competitive; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Neprilysin; Tissue Distribution; Tritium | 1991 |
Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Mollusk Venoms; Naltrexone; Narcotic Antagonists; omega-Conotoxin GVIA; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
Topics: Animals; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Sympathoadrenal control by paraventricular hypothalamic beta-endorphin in hypertension.
Topics: Animals; Behavior, Animal; beta-Endorphin; Blood Glucose; Blood Pressure; Catecholamines; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heart Rate; Hypertension; Male; Naltrexone; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1991 |
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Up-Regulation | 1990 |
Nor-binaltorphimine decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Food Deprivation; Male; Naltrexone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Reference Values | 1990 |
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors.
Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Food Deprivation; Guinea Pigs; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule | 1990 |
Characterisation of opioid binding sites using selective antagonists.
Topics: Animals; Binding, Competitive; Brain; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Morphinans; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
Reflex peristalsis in the guinea pig isolated ileum is endogenously controlled by kappa opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peristalsis; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Somatostatin | 1990 |
Tonic opioid inhibition of the pressor region of the rostral ventrolateral medulla of rabbits is mediated by delta receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Hemodynamics; Male; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Pressoreceptors; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Local enkephalins tonically modulate dopamine release in the striatum: a microdialysis study.
Topics: Amino Acid Sequence; Aminopeptidases; Analgesics; Animals; CD13 Antigens; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dipeptides; Dopamine; Enkephalins; Male; Molecular Sequence Data; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Substrate Specificity | 1990 |
The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors.
Topics: Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium; Vas Deferens | 1990 |
Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid | 1990 |
Delta opioid antagonist, naltrindole, selectively blocks analgesia induced by DPDPE but not DAGO or morphine.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Restraint, Physical; Stress, Psychological | 1991 |
Regulation of proenkephalin A gene expression in aggregating fetal rat brain cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Brain; Cell Aggregation; Dexamethasone; Enkephalins; Etorphine; Gene Expression Regulation; Naltrexone; Neurons; Potassium Chloride; Protein Precursors; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Veratridine | 1991 |
Conformational search in enkephalin analogues containing a disulfide bond.
Topics: Amino Acid Sequence; Disulfides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Models, Molecular; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Thermodynamics | 1990 |
Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amino Acid Sequence; Animals; Diuresis; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Naltrexone; Oligopeptides; Phenazocine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens | 1990 |
Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.
Topics: Animals; Benzomorphans; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Esters; Ethers; In Vitro Techniques; Ligands; Methacrylates; Naltrexone; Receptors, Opioid; Structure-Activity Relationship | 1990 |
[3H] beta-funaltrexamine ([3H] beta-FNA) binds irreversibly to mu opioid receptors in the rat brain: autoradiographic study.
Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Delta but not mu-opioid receptors in the spinal cord are involved in antinociception induced by beta-endorphin given intracerebroventricularly in mice.
Topics: Analgesia; Animals; beta-Endorphin; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
A lack of potency for the delta-opioid antagonist naltrindole after microinjection into the rostral ventrolateral medulla of rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Indoles; Male; Medulla Oblongata; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological | 1990 |
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective delta agonist in vivo.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Modulation of opioid receptor binding by cis and trans fatty acids.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fatty Acids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism | 1990 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming; Thiorphan | 1990 |
Role of opioid receptors in the long-lasting blood pressure depression after electric muscle stimulation in the hind leg of the rat.
Topics: Animals; Benzomorphans; Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart Rate; Hindlimb; Male; Naloxone; Naltrexone; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Receptors, Opioid; Regional Blood Flow | 1990 |
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1990 |
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation | 1990 |
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior | 1990 |
Pharmacological regulation of striatal prodynorphin peptides.
Topics: Amphetamine; Animals; Corpus Striatum; Drug Interactions; Enkephalins; Haloperidol; Male; Morphine; Naltrexone; Protein Precursors; Rats; Rats, Inbred Strains; Substantia Nigra | 1990 |
Chronic naltrexone treatment increases expression of preproenkephalin and preprotachykinin mRNA in discrete brain regions.
Topics: Animals; Brain; Enkephalins; Male; Naltrexone; Protein Precursors; Rats; RNA, Messenger; Tachykinins; Time Factors; Tissue Distribution | 1990 |
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
Topics: Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1985 |
Oxymorphone-naltrexonazine, a mixed opiate agonist-antagonist.
Topics: Analgesia; Animals; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; Male; Mice; Mice, Inbred ICR; Naltrexone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1987 |
Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats.
Topics: Animals; beta-Endorphin; Corpus Striatum; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Morphine; Naltrexone; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Substance Withdrawal Syndrome | 1989 |
Relationship between opioid-receptor occupancy and stimulation of low-Km GTPase in brain membranes.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; Guanosine Triphosphate; Magnesium; Membranes; Naltrexone; Oligopeptides; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1989 |
Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Seizures | 1989 |
Opioid antagonist modulation of murine neuroblastoma: a profile of cell proliferation and opioid peptides and receptors.
Topics: Animals; Cell Division; Cell Line; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Receptors, Opioid | 1989 |
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
Topics: Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Up-regulation of opiate receptors following chronic naltrexone treatment in mature and aged male and female rats.
Topics: Aging; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid | 1989 |
Effects of selective opioid-receptor blockade on the hypothalamo-pituitary-adrenocortical responses to surgical trauma in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological | 1989 |
Inhibition of vagal transmission by cardiac sympathetic nerve stimulation in the dog: possible involvement of opioid receptor.
Topics: Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart; Heart Rate; Methacholine Chloride; Methacholine Compounds; Naloxone; Naltrexone; Norepinephrine; Prazosin; Receptors, Opioid; Sympathetic Nervous System; Synaptic Transmission; Vagus Nerve; Yohimbine | 1989 |
A high affinity, highly selective ligand for the delta opioid receptor: [3H]-[D-Pen2, pCl-Phe4, d-Pen5]enkephalin.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus.
Topics: Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphine; Naltrexone; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
A mu-specific opioid peptide agonist increases excitability of pyramidal neurons in untreated and receptor up-regulated hippocampus.
Topics: Action Potentials; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Up-Regulation | 1989 |
Delta-opioid mediated inhibitions of acute and prolonged noxious-evoked responses in rat dorsal horn neurones.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Evoked Potentials; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Chronic opioid antagonist treatment: assessment of receptor upregulation.
Topics: Animals; Binding, Competitive; Brain Chemistry; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Up-Regulation | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
Evidence for the presence of disulfide bridges in opioid receptors essential for ligand binding. Possible role in receptor activation.
Topics: Animals; Brain; Cattle; Cell Membrane; Chemical Phenomena; Chemistry; Disulfides; Dithiothreitol; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ligands; Molecular Weight; Naltrexone; Receptors, Opioid | 1989 |
Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Lack of mixed agonist-antagonist properties of [Gln8-Gly31]-beta h-EP-Gly-Gly-NH2 and [Arg9,19,24,28,29]-beta h-EP in the rat vas deferens neuroeffector junction: studies with naloxone, beta-funaltrexamine and ICI 174,864.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neuroeffector Junction; Rats; Rats, Inbred Strains; Vas Deferens | 1989 |
Evidence that the aversive effects of opioid antagonists and kappa-agonists are centrally mediated.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Conditioning, Operant; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin | 1989 |
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Sulfhydryl Reagents | 1989 |
Effects of beta-funaltrexamine on radiolabeled opioid binding.
Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1987 |
Cellular mechanisms of opioid tolerance: studies in single brain neurons.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Derivatives; Naltrexone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
Topics: Animals; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Chronic morphine upregulates a mu-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography.
Topics: Alkylating Agents; Animals; Binding, Competitive; Drug Tolerance; Enkephalin, Leucine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tomography, Emission-Computed | 1987 |
Opioid analgesia in the mouse: evidence for multiple receptors using beta-FNA.
Topics: Analgesia; Animals; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid | 1986 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Molecular; Morphine; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 1988 |
Effect of ethanol on the binding of conformationally rigid and labile ligands of opioid receptors to rat brain membranes.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; In Vitro Techniques; Male; Naltrexone; Oligopeptides; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Opioid gene expression in rat striatum is modulated via opioid receptors: evidence from localized receptor inactivation.
Topics: Animals; Corpus Striatum; Enkephalins; Gene Expression Regulation; Male; Naltrexone; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; RNA, Messenger | 1988 |
Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
Topics: Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Naltrexone; Pertussis Toxin; Protein Binding; Receptors, Opioid; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1988 |
Estimation of opioid receptor agonist dissociation constants with beta-chlornaltrexamine, an irreversible ligand which also displays agonism.
Topics: Animals; Cyclazocine; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Influence of neonatal opioid blockade or injections of gonadotrophin-releasing hormone on the timing of puberty in female rats: correlation of opioid effects with occupation of hypothalamic mu-opioid receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hypothalamus; Naloxone; Naltrexone; Pituitary Hormone-Releasing Hormones; Rats; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation; Time Factors | 1988 |
Lack of evidence for epsilon-opioid receptors in the rat vas deferens.
Topics: Animals; Calcium; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1988 |
Inhibition by opioid agonists and enhancement by antagonists of the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation: evidence for the functional role of opioid receptors.
Topics: Adrenal Glands; Animals; Catecholamines; Dogs; Electric Stimulation; Enkephalin, Leucine; Female; Male; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Splanchnic Nerves | 1988 |
Treatment of stroke with opiate antagonists--effects of exogenous antagonists and dynorphin 1-13.
Topics: Acute Disease; Animals; Brain Ischemia; Cats; Dynorphins; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments | 1985 |
Non-dopaminergic mechanisms in the turning behavior evoked by intranigral opiates.
Topics: Animals; Dynorphins; Enkephalins; Hydroxydopamines; Male; Medial Forebrain Bundle; Morphine; Movement; Naltrexone; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
[Frequency as the cardinal determinant for electroacupuncture analgesia to be reversed by opioid antagonists].
Topics: Acupuncture Therapy; Animals; beta-Endorphin; Dynorphins; Electric Stimulation Therapy; Endorphins; Enkephalins; Naloxone; Naltrexone; Pain; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Effects of beta-chlornaltrexamine on food intake, body weight and opioid-induced feeding.
Topics: Animals; Body Weight; Dynorphins; Eating; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
Topics: Animals; Autoradiography; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Membranes; Tomography, Emission-Computed | 1988 |
Pharmacological evidence of a central effect of naltrexone, morphine, and beta-endorphin and a peripheral effect of met- and leu-enkephalin on retention of an inhibitory response in mice.
Topics: Adrenal Medulla; Animals; Avoidance Learning; beta-Endorphin; Brain; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Memory; Mice; Morphine; Naltrexone; Quaternary Ammonium Compounds; Retention, Psychology | 1985 |
Opioid-mediated cardiovascular effects of clonidine in spontaneously hypertensive rats: elimination by neonatal treatment with monosodium glutamate.
Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Glutamates; Heart Rate; Hemodynamics; Hypertension; Medulla Oblongata; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Glutamate | 1986 |
Possible delta receptor mediation of the effect of beta-endorphin on luteinizing hormone (LH) release, but not on prolactin (PRL) release, in the ovariectomized rat.
Topics: Animals; beta-Endorphin; Castration; Endorphins; Enkephalin, Leucine; Female; Kinetics; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
TENA, a selective kappa opioid receptor antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment.
Topics: Animals; Binding, Competitive; Brain; Drug Implants; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Time Factors | 1985 |
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
An opiate receptor-associated aminopeptidase that degrades enkephalins.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Brain; Chromatography, Affinity; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naltrexone; Oligopeptides; Peptides; Rats; Receptors, Opioid | 1985 |
Are delta-opioid receptors involved in the regulation of food and water intake?
Topics: Animals; Benzomorphans; Drinking Behavior; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Injections, Intraperitoneal; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
A radiolabeled-ligand-binding technique for the characterization of opioid receptors in the intact mouse vas deferens.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Mice; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid; Vas Deferens | 1985 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. I. Morphine-like discriminative stimulus effects.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine Dependence; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Lethal Dose 50; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Time Factors | 1986 |
Irreversible selective blockade of kappa-opioid receptors in the guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Selective proliferation of brain kappa opiate receptors in spontaneously hypertensive rats.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; Kinetics; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Delta receptors in the rat vas deferens.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1986 |
Unidirectional interaction between thyrotropin releasing hormone and opiates at the level of their brain receptors.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; Male; Naltrexone; Oligopeptides; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Thyrotropin-Releasing Hormone | 1987 |
Nonequilibrium opioid antagonist activity of 6,14-dideoxynaltrexone derivatives.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Multiple interconvertible affinity states for the delta opioid agonist-receptor complex.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes | 1987 |
Modulation of human neuroblastoma transplanted into nude mice by endogenous opioid systems.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Naltrexone; Neoplasm Transplantation; Neuroblastoma; Receptors, Opioid; Transplantation, Heterologous | 1987 |
Possible mediation of catecholaminergic pathways in the antinociceptive effect of an extract of Cannabis sativa L.
Topics: Analgesics; Animals; Benzomorphans; Cannabis; Dose-Response Relationship, Drug; Enkephalin, Leucine; Haplorhini; Hydroxydopamines; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oxidopamine; Plant Extracts; Rats; Rats, Inbred Strains | 1986 |
Effects of opioid peptides on aldosterone production: stimulatory effect of leu-enkephalin.
Topics: Adrenal Cortex; Aldosterone; Animals; Cattle; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Perfusion | 1988 |
Effect of endorphins on heart rate and blood pressure in adult dogs.
Topics: Animals; Atropine; Blood Pressure; Consciousness; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; Heart Rate; Naloxone; Naltrexone | 1986 |
Evidence for opioid and non-opioid forms of stress-induced analgesia in the snail, Cepaea nemoralis.
Topics: Animals; Cold Temperature; Endorphins; Enkephalin, Leucine; Hot Temperature; Naloxone; Naltrexone; Pain; Reaction Time; Snails; Stress, Physiological | 1987 |
Enkephalin release into the ventral tegmental area in response to stress: modulation of mesocorticolimbic dopamine.
Topics: Animals; Dopamine; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Septal Nuclei; Stress, Physiological; Tegmentum Mesencephali | 1987 |
Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain.
Topics: Animals; Brain Chemistry; Chlorocebus aethiops; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Morphine; Naltrexone; Substance Withdrawal Syndrome | 1986 |
Asymmetric behavior induced by enkephalinergic agents in the basal ganglia.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains | 1985 |
Effect of beta-FNA on opiate delta receptor binding.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Oligopeptides; Protein Conformation; Rats; Receptors, Opioid | 1984 |
Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds.
Topics: Animals; Antidepressive Agents; Binding, Competitive; Cerebellum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Kinetics; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Mu and delta opioid receptor interactions in a rat model of drug induced seizures.
Topics: Animals; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1984 |
Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin.
Topics: Animals; Body Temperature; Body Temperature Regulation; Cats; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1984 |
Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with mu- and delta-receptors.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Naltrexone; Receptors, Opioid; Structure-Activity Relationship | 1980 |
The in vitro pharmacology of D-Met2,Pro5-enkephalinamide.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotics; Nictitating Membrane; Rats; Receptors, Opioid; Vas Deferens | 1981 |
Suppression of ethanol consumption by MET-enkephalin in rats.
Topics: Alcohol Drinking; Animals; Depression, Chemical; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Naltrexone; Rats | 1982 |
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Opioid receptor selectivity of dynorphin gene products.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Peptide Fragments; Protein Precursors; Receptors, Opioid | 1984 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
The role of opioid receptor sub-types in tifluadom-induced feeding.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Convulsants; Eating; Enkephalin, Leucine; Flumazenil; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1984 |
Quaternary opiate antagonists lower blood pressure and inhibit leucine-enkephalin responses.
Topics: Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Heart Rate; Hydromorphone; Naloxone; Naltrexone; Oxymorphone; Quaternary Ammonium Compounds | 1983 |
Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Ethylmaleimide; Kinetics; Ligands; Male; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1980 |
Opiate receptors: problems of definition and characterization.
Topics: Animals; Binding Sites; Brain; Caudate Nucleus; Cyclazocine; Endorphins; Enkephalins; Hippocampus; Humans; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1980 |
The effects of opiate agonists on growth hormone and prolactin release in rats.
Topics: Animals; Apomorphine; Enkephalins; Growth Hormone; Male; Methadone; Morphine; Naloxone; Naltrexone; Parasympathomimetics; Prolactin; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Opioid; Secretory Rate | 1980 |
Location and characterization of opiate receptors regulating pituitary secretion.
Topics: Animals; Apomorphine; Chromatography, Gel; Corpus Striatum; Endorphins; Enkephalins; Female; Growth Hormone; Hypothalamus; Luteinizing Hormone; Morphine; Naltrexone; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Opioid; Thyrotropin | 1980 |
Depressant and excitant effects of intraspinal microinjections of morphine and methionine-enkephalin in the cat.
Topics: Animals; Cats; Endorphins; Enkephalins; Evoked Potentials; Female; Ganglia, Spinal; Male; Morphine; Motor Neurons; Naltrexone; Nerve Fibers; Nociceptors; Reflex; Spinal Cord; Synapses; Synaptic Transmission | 1980 |
Opioid peptides and their receptors.
Topics: Animals; Brain; Dogs; Endorphins; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Receptors, Opioid; Vas Deferens | 1980 |
Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus.
Topics: Animals; Binding, Competitive; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Peptide Fragments; Receptors, Opioid | 1981 |
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons | 1981 |
Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.
Topics: Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Naloxone; Naltrexone; Narcotics; Phenoxybenzamine; Receptors, Opioid | 1981 |
Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.
Topics: Animals; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Nitrogen Mustard Compounds; Prostaglandins E, Synthetic; Rats; Receptors, Opioid | 1981 |
Effects of opioid peptides on thermoregulation.
Topics: Animals; beta-Endorphin; Body Temperature Regulation; Cats; Cattle; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Naloxone; Naltrexone; Narcotics; Rats; Structure-Activity Relationship | 1981 |
Naltrexone-induced opiate receptor supersensitivity.
Topics: Animals; Brain; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Female; Guanosine Triphosphate; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid | 1983 |
Analgesia induced by electroconvulsive shock: brain enkephalins may mediate tolerance but not the induction of analgesia.
Topics: Animals; Brain; Drug Tolerance; Electroshock; Enkephalins; Male; Morphine; Muridae; Naltrexone; Nociceptors; Receptors, Opioid; Sensory Thresholds; Synaptic Transmission | 1983 |
Multi-dimensional analyses of behavior in mice treated with morphine, endorphins and [des-tyrosine1]-gamma-endorphin.
Topics: Animals; Behavior, Animal; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Peptide Fragments | 1983 |
Evidence for delta-receptor involvement in the post-ictal antinociceptive responses to electroconvulsive shock in rats.
Topics: Animals; Electroshock; Enkephalin, Leucine; Escape Reaction; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Multiple opioid receptors: evidence for mu-delta binding site interactions in endotoxic shock.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Heart Rate; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pulse; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Shock, Septic | 1983 |
ICI 154,129, a delta-opioid receptor antagonist raises seizure threshold in rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Multiple opioid receptors in endotoxic shock: evidence for delta involvement and mu-delta interactions in vivo.
Topics: Allosteric Regulation; Animals; Blood Pressure; Enkephalin, Leucine; Macromolecular Substances; Male; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Shock, Septic | 1984 |
Differential role of the opioid mu and delta receptors in the activation of prolactin (PRL) and growth hormone (GH) secretion by morphine in the male rat.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Growth Hormone; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Opioid antagonism of electroshock-induced seizures.
Topics: Animals; beta-Endorphin; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Seizures; Time Factors | 1984 |
Stereospecific enhancement of evoked release of brain acetylcholine by narcotic antagonists.
Topics: Acetylcholine; Animals; Brain; Electric Stimulation; Enkephalins; Hypophysectomy; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Stereoisomerism | 1983 |
Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat.
Topics: Animals; Choice Behavior; Drinking Behavior; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Saccharin | 1983 |
Adrenal medullary enkephalin-like peptides may mediate opioid stress analgesia.
Topics: Adrenal Medulla; Analgesia; Animals; Electroshock; Endorphins; Enkephalins; Male; Morphine; Naltrexone; Rats; Reserpine; Sodium Chloride; Stress, Physiological; Time Factors | 1982 |
Opiate regulation of angiotensin-induced drinking and vasopressin release.
Topics: Angiotensin II; Animals; Drinking; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Saralasin; Vasopressins | 1981 |
Self-administration of D-Ala2-Met-enkephalinamide at hypothalamic self-stimulation sites.
Topics: Animals; Dextrorphan; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Hypothalamus; Levallorphan; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Rats; Self Stimulation | 1980 |
Reversible modulation of opioid receptor binding in intact neural cells by endogenous guanosine triphosphate.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Kinetics; Molecular Sequence Data; Mycophenolic Acid; Naltrexone; Narcotic Antagonists; Neuroblastoma; Neurons; Receptors, Opioid, mu; Tritium; Tumor Cells, Cultured | 1995 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Female; GTP-Binding Proteins; Naltrexone; Oocytes; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases; Xenopus laevis | 1995 |
Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin.
Topics: Analgesics; Animals; Drug Synergism; Enkephalins; Injections, Spinal; Male; Naltrexone; Pain; Pain Measurement; Rats; Rats, Wistar; Substance P | 1994 |
Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes.
Topics: Aging; Analgesics; Animals; Carbazoles; Cell Membrane; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guinea Pigs; Indoles; Kinetics; Male; Naltrexone; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Species Specificity | 1994 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia.
Topics: Amino Acid Sequence; Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Foot; Ganglia, Spinal; Inflammation; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu; Ribonucleases; RNA, Messenger | 1995 |
Antinociception and delta-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1995 |
Characterization of the spinal antinociceptive activity of constrained peptidomimetic opioids.
Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Injections, Spinal; Male; Mice; Molecular Sequence Data; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Structure-Activity Relationship; Vas Deferens | 1995 |
Electrophysiological demonstration and activation of mu-opioid receptors in the rabbit sinoatrial node.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Fentanyl; Microelectrodes; Naltrexone; Narcotic Antagonists; Narcotics; Patch-Clamp Techniques; Rabbits; Receptors, Opioid, mu; Sinoatrial Node | 1995 |
Effects of mu opioid agonist and antagonist on neurological outcome following traumatic brain injury in the rat.
Topics: Animals; Brain Injuries; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Treatment Outcome | 1995 |
Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Amino Acid Sequence; Cell Line; Colforsin; Culture Media, Conditioned; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Receptors, Opioid, delta | 1995 |
Effects of a highly selective nonpeptide delta opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice.
Topics: Analgesics; Animals; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Nociceptors; Oligopeptides; Quinolines; Receptors, Opioid, delta | 1995 |
Human delta opioid receptor: a stable cell line for functional studies of opioids.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins | 1995 |
Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Glycosylation; Molecular Sequence Data; Naltrexone; Oligopeptides; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sodium; Tritium | 1995 |
mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle.
Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Aorta; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin | 1995 |
Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine.
Topics: Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Ketorolac Tromethamine; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tolmetin; Tromethamine | 1995 |
Delta opioid agonists inhibit proliferation of highlypurified murine CD4+ and CD8+ T-cells.
Topics: Analgesics; Animals; CD4 Antigens; CD8 Antigens; Cell Division; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; T-Lymphocytes | 1995 |
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella | 1993 |
Expression of functional delta opioid receptors in Xenopus oocytes.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Glioma; Hybrid Cells; Isoproterenol; Mice; Naltrexone; Neuroblastoma; Oocytes; Poly A; Rats; Receptors, Opioid, delta; RNA; RNA, Messenger; Xenopus laevis | 1993 |
Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Analgesics; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homovanillic Acid; Hydroxyindoleacetic Acid; Limbic System; Male; Microinjections; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali | 1993 |
Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception.
Topics: Animals; Drug Synergism; Enkephalin, Leucine; Immune Sera; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Oligonucleotides, Antisense; Receptors, Cholecystokinin | 1994 |
Evidence for functional delta-opiate receptors in the rat intestine.
Topics: Acetylcholine; Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Jejunum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 1994 |
Activation of mu-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons.
Topics: Action Potentials; Amino Acid Sequence; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Sequence Data; Muscimol; Naloxone; Naltrexone; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Spinal Cord | 1994 |
Opioid effects on spinal [3H]5-hydroxytryptamine release are not related to their antinociceptive action.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Isotope Labeling; Male; Molecular Sequence Data; Naltrexone; Narcotics; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin; Somatostatin; Spinal Cord; Synaptic Transmission; Synaptosomes | 1995 |
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Species Specificity; Spinal Cord | 1995 |
The contribution of delta 1- and delta 2-opioid receptors to hypoxia-induced pial artery dilation in the newborn pig.
Topics: Animals; Animals, Newborn; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypoxia; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pia Mater; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Increased opioid binding to peripheral white blood cells in a rat model of acute cholestasis.
Topics: Acute Disease; Animals; Cholestasis; Disease Models, Animal; Enkephalins; Flow Cytometry; Leukocytes; Lymphocytes; Male; Monocytes; Naltrexone; Neutrophils; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101.
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalins; Enzyme Inhibitors; Male; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Phenylalanine; Receptors, Cholecystokinin | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu | 1995 |
Long-term exposure to opioid antagonists up-regulates prodynorphin gene expression in rat brain.
Topics: Animals; Brain; Enkephalins; Gene Expression; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Precursors; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Absence; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Naltrexone; Pyrroles; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1995 |
Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium | 1995 |
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
Topics: Amino Acid Sequence; Animals; Brain Neoplasms; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured | 1994 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin | 1994 |
The effect of chronic treatment with naltrindole, a selective delta-opioid antagonist, on mu-opioid receptor-mediated antinociception in diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spleen | 1993 |
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice.
Topics: Analgesics; Animals; Benzylidene Compounds; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Long-term sensitization to the behavioral effects of naltrexone is associated with regionally specific changes in the number of mu and delta opioid receptors in rat brain.
Topics: Animals; Behavior, Animal; Brain; Cerebral Cortex; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mesencephalon; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Rhombencephalon; Salivation; Tritium | 1995 |
Effects of the delta-opioid agonist, [D-Pen2,D-Pen5]-enkephalin, on fetal lamb EEG.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Fetus; Injections, Intraventricular; Naltrexone; Narcotic Antagonists; Pregnancy; Receptors, Opioid, delta; Sheep | 1994 |
Alkylation of mu opioid receptors by beta-funaltrexamine in vivo: comparison of the effects on in situ binding and heroin self-administration in rats.
Topics: Alkylation; Animals; Behavior, Animal; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; In Vitro Techniques; Injections, Intraventricular; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Self Administration | 1995 |
Influence of hypertension development on rat tail artery responses to opioid peptides.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Tail; Vasoconstriction | 1995 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
Topics: Animals; Benzimidazoles; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, mu; Spinal Cord | 1994 |
Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 1994 |
Semiparametric models for antagonistic drug interactions.
Topics: Animals; Binding, Competitive; Drug Antagonism; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Models, Biological; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1994 |
The kappa agonist fedotozine modulates colonic distention-induced inhibition of gastric motility and emptying in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzyl Compounds; Bretylium Compounds; Catheterization; Colon; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Emptying; Gastrointestinal Motility; Granisetron; Hexamethonium; Male; Naltrexone; Narcotic Antagonists; Propylamines; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Stomach | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides | 1994 |
Differential modulation of behavioral responses by [D-Ala2, NMePhe4, Gly-ol]enkephalin, [D-Ala2] deltorphin II and [D-Pen2, L-Pen5]enkephalin in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Naltrexone; Oligopeptides | 1994 |
Evidence for chemical differentiation of delta opioid receptor subtypes by the sulfhydryl reagent N-ethylmaleimide.
Topics: Affinity Labels; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Isothiocyanates; Male; Mice; Naltrexone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice.
Topics: Analgesia; Animals; Benzimidazoles; Cinnamates; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1994 |
The effect of naltrindole on spinal and supraspinal delta opioid receptors and analgesia.
Topics: Analgesia; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Kinetics; Male; Mice; Naltrexone; Pain Measurement; Receptors, Opioid, delta; Spinal Cord | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Beta-funaltrexamine blockade of opioid-induced inhibition of somatostatin secretion from rat stomach.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Radioimmunoassay; Rats; Rats, Wistar; Somatostatin | 1994 |
The effects of protection by D-Pen2-D-Pen5-enkephalin or D-Ala2-NMePhe4-Gly-ol-enkephalin against beta-chlornaltrexamine in the spinal cord on the antinociception induced by beta-endorphin administered intracerebroventricularly in the mouse.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Spinal Cord | 1994 |
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1994 |
Evidence that weaning stimulates the developmental expression of a delta-opioid receptor subtype in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Weaning | 1994 |
Characterization of opioid binding sites in the neural and intermediate lobe of the rat pituitary gland by quantitative receptor autoradiography.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Densitometry; Enkephalins; Ligands; Male; Molecular Sequence Data; Naloxone; Naltrexone; Pituitary Gland; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, kappa | 1994 |
Effect of morphine tolerance and abstinence on the binding of [3H]naltrexone to discrete brain regions and spinal cord of the rat.
Topics: Analgesics; Animals; Brain; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Membranes; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 1994 |
TRIMU-5, a mu 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis.
Topics: Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Kinetics; Male; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1994 |
Streptozotocin-induced diabetes selectively enhances antinociception mediated by delta 1- but not delta 2-opioid receptors.
Topics: Analgesia; Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin | 1994 |
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 1994 |
Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cerebral Ventricles; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression; GTP-Binding Proteins; In Situ Hybridization; Infusions, Parenteral; Male; Naltrexone; Narcotics; Oligonucleotide Probes; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Multiple opiate receptor subtypes are involved in the stimulation of growth hormone release by beta-endorphin in female rats.
Topics: Animals; beta-Endorphin; Diestrus; Enkephalin, Leucine; Female; Growth Hormone; Kinetics; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Effects of opioid receptors antagonists administration to suprachiasmatic nucleus on hibernation of ground squirrels Citellus dauricus.
Topics: Animals; Endorphins; Enkephalin, Leucine; Female; Hibernation; Injections; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sciuridae; Suprachiasmatic Nucleus | 1993 |
Regulatory role of enteric kappa opioid receptors in human colonic motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Colon, Sigmoid; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Gastrointestinal Motility; Humans; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Effects of naltrexone on the binding of [3H]D-Ala2, MePhe4, Gly-ol5-enkephalin to brain regions and spinal cord and pharmacological responses to morphine in the rat.
Topics: Analgesics; Animals; Body Temperature; Brain; Drug Implants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Up-Regulation | 1993 |
Delta-1 opioid agonist acutely increases hypoxic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Benzylidene Compounds; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypoxia; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid, delta | 1994 |
Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Characterization of [3H]naltrindole binding to delta opioid receptors in mouse brain and mouse vas deferens: evidence for delta opioid receptor heterogeneity.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Vas Deferens | 1994 |
Opioids regulation of human chorionic gonadotropin release from trophoblast tissue is mediated by gonadotropin releasing hormone.
Topics: Chorionic Gonadotropin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gonadotropin-Releasing Hormone; Humans; In Vitro Techniques; Naltrexone; Narcotics; Pregnancy; Receptors, Opioid, kappa; Trophoblasts | 1994 |
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry.
Topics: Analgesia; Analgesics; Animals; Conditioning, Classical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immune Sera; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 1994 |
Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine.
Topics: Analgesics; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1994 |
The decompensatory phase of acute hypovolaemia in rabbits involves a central delta 1-opioid receptor.
Topics: Animals; Benzylidene Compounds; Blood Pressure; Cardiac Output; Enkephalin, Leucine; Hemodynamics; Hemorrhage; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Shock | 1994 |
mu-Opioid receptors modulate noradrenaline release from the rat hippocampus as measured by brain microdialysis.
Topics: Analgesics; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extracellular Space; GTP-Binding Proteins; Hippocampus; Male; Microdialysis; Morphine; Naltrexone; Nerve Endings; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1994 |
Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid, delta | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Identification of a human delta opioid receptor: cloning and expression.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Consensus Sequence; Enkephalins; Humans; Mice; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Oligopeptides; Open Reading Frames; Receptors, Opioid, delta; Sequence Alignment; Transfection | 1994 |
Multiple opioid system involvement in the mediation of parasitic-infection induced analgesia.
Topics: Analgesia; Animals; Coccidiosis; Endorphins; Enkephalin, Leucine; Host-Parasite Interactions; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists | 1993 |
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.
Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis | 1993 |
Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Bicuculline; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naltrexone; Narcotics; Oligopeptides; Picrotoxin; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, kappa; Synaptosomes | 1993 |
Naltrexone-induced upregulation of mu opioid receptors on 7315c cell and brain membranes: enhancement of opioid efficacy in inhibiting adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Membrane; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Naltrexone; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation | 1993 |
Effects of intracerebroventricular administration of beta-funaltrexamine on [3H]DAMGO binding to rat brain sections.
Topics: Animals; Autoradiography; Brain Mapping; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu | 1993 |
Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination Learning; Enkephalin, Leucine; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Midazolam; Molecular Sequence Data; Naltrexone; Pentylenetetrazole; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1993 |
Differential antagonism by naltrindole-5'-isothiocyanate on [3H]DSLET and [3H]DPDPE binding to striatal slices of mice.
Topics: Analgesics; Animals; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Male; Mice; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Tritium | 1993 |
Binding in vivo of selective mu and delta opioid agonists: localization by autoradiography.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding, Competitive; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord | 1993 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
delta-Opioid receptor-mediated regulation of central dopaminergic neurons in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurons; Rats; Receptors, Opioid, delta | 1993 |
Arousal following intra-preoptic area administration of naltrexone, ICI 174864 or nor-BNI in hibernating ground squirrels.
Topics: Animals; Arousal; Brain Mapping; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Hibernation; Male; Naltrexone; Narcotic Antagonists; Preoptic Area; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciuridae | 1993 |
DAMGO ([D-Ala2,NMePhe4,Gly-ol]enkephalin), but not DPLPE ([D-Pen2,L- Pen5]enkephalin), specifically inhibits methamphetamine-induced behavioral responses in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Methamphetamine; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists | 1993 |
Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Benzylidene Compounds; Caudate Nucleus; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
Sex differences in the antinociceptive effects of the enkephalinase inhibitor, SCH 34826.
Topics: Analgesia; Analgesics; Animals; Dioxolanes; Dipeptides; Enkephalin, Leucine; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Peromyscus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Sex Characteristics; Stress, Psychological | 1993 |
Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice.
Topics: Analgesics; Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Time Factors; Virulence Factors, Bordetella | 1993 |
Effect of diabetes on the antinociceptive effect of beta-endorphin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Reference Values | 1993 |
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Analgesics; Animals; Binding, Competitive; Bombesin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Naltrexone; Oximes; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration | 1993 |
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens.
Topics: Animals; Benzylidene Compounds; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Thiocyanates; Vas Deferens | 1993 |
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat.
Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord.
Topics: Analgesics; Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Spinal Cord | 1993 |
Involvement of delta 2 opioid receptors in the development of morphine dependence in mice.
Topics: Animals; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Thiocyanates | 1993 |
Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Cyclic AMP; Down-Regulation; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; Humans; Levorphanol; Molecular Sequence Data; Naltrexone; Narcotics; Neuroblastoma; Neurons; Receptors, Opioid; Signal Transduction; Tumor Cells, Cultured | 1993 |
Thermodynamic parameters for [D-Pen2,5]enkephalin at delta-opioid receptors in the mouse isolated vas deferens.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Naltrexone; Receptors, Opioid, delta; Temperature; Thermodynamics; Vas Deferens | 1993 |
Differential modulation of mu-opioid receptor-mediated antitussive activity by delta-opioid receptor agonists in mice.
Topics: Animals; Antitussive Agents; Cough; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord | 1993 |
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1993 |
Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering mu-opioid receptor sensitivity.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Brain; Catecholamines; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Norepinephrine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Opioid, mu | 1993 |
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1993 |
Involvement of delta 2 opioid receptors in acute dependence on morphine in mice.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphine; Naltrexone; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal | 1993 |
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis.
Topics: Analgesics; Animals; Benzeneacetamides; Dialysis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; Male; Micromanipulation; Morphine; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin | 1993 |
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal | 1993 |
Evidence for delta opioid receptor subtypes in rat spinal cord: studies with intrathecal naltriben, cyclic[D-Pen2, D-Pen5] enkephalin and [D-Ala2, Glu4]deltorphin.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Reflex; Spinal Cord | 1993 |
DAMGO stimulates the hypothalamo-pituitary-adrenal axis through a mu-2 opioid receptor.
Topics: Analgesics; Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Altered transition between agonist- and antagonist-favoring states of mu-opioid receptor in brain membranes with modified microviscosity.
Topics: Animals; Brain; Cholesterol Esters; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Male; Membrane Fluidity; Membranes; Naltrexone; Oleic Acid; Oleic Acids; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Viscosity | 1993 |
Role of mu 1- and delta-opioid receptors in modulation of fetal EEG and respiratory activity.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetal Movement; Fetus; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep | 1993 |
Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Involvement of delta-opioid receptors in physical dependence on butorphanol.
Topics: Animals; Butorphanol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance-Related Disorders | 1993 |
Opiate receptor subtype involvement in the stimulation of prolactin release by beta-endorphin in female rats.
Topics: Animals; beta-Endorphin; Diestrus; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Lactation; Male; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1993 |
Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens.
Topics: Analgesics; Animals; Anticonvulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Naltrexone; Oligopeptides; Pyrroles; Receptors, Opioid, delta; Thiophenes; Vas Deferens | 1993 |
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter.
Topics: Amino Acid Transport Systems, Neutral; Animals; Brain; Enkephalins; HeLa Cells; Humans; Male; Membrane Transport Modulators; Membrane Transport Proteins; Naltrexone; Proline; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1996 |
Effects of cold acclimation and central opioid processes on thermoregulation in rats.
Topics: Acclimatization; Analgesics; Animals; Body Temperature; Body Temperature Regulation; Cold Temperature; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Grooming; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Salivary Glands; Telemetry | 1996 |
Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Oxidopamine; Peptide Fragments; Receptors, Opioid | 1995 |
Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Kinetics; Male; Naltrexone; Narcotic Antagonists; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reference Values; RNA, Messenger; Up-Regulation | 1995 |
Ocular action of an opioid peptide, DPDPE.
Topics: Administration, Topical; Analgesics; Animals; Ciliary Body; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Intraocular Pressure; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits | 1996 |
Gene-peptide relationships in the developing rat brain: the response of preproenkephalin mRNA and [Met5]-enkephalin to acute opioid antagonist (naltrexone) exposure.
Topics: Animals; Caudate Nucleus; Cerebellum; Enkephalin, Methionine; Enkephalins; Female; Male; Naltrexone; Narcotic Antagonists; Protein Precursors; Putamen; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1995 |
Effects of beta-FNA on sympathoadrenal, cardiovascular, and analgesic responses to DAMPGO at rest and during stress.
Topics: Adrenal Glands; Analgesics; Animals; Blood Pressure; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heart Rate; Hemodynamics; Male; Naltrexone; Narcotic Antagonists; Organ Size; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stress, Psychological; Sympathetic Nervous System | 1996 |
Alcohol drinking is reduced by a mu 1- but not by a delta-opioid receptor antagonist in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 1996 |
Involvement of beta-endorphin in the modulation of paw inflammatory edema in the rat.
Topics: Animals; Antibodies; Benzomorphans; beta-Endorphin; Edema; Enkephalin, Leucine; Foot; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Yeasts | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
Effect of the highly selective and nonpeptide delta opioid receptor agonist TAN-67 on the morphine-induced place preference in mice.
Topics: Analgesics; Animals; Benzylidene Compounds; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Limbic System; Male; Mice; Morphine; Naltrexone; Quinolines; Receptors, Opioid, delta; Reward | 1996 |
Reductions in locomotor activity following central opioid receptor subtype antagonists in rats.
Topics: Animals; Enkephalins; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley | 1996 |
Comparison of cyclic delta-opioid peptides with non-peptide delta-agonist spiroindanyloxymorphone (SIOM) using the message-address concept: a molecular modeling study.
Topics: Drug Design; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Naltrexone; Narcotic Antagonists; Oxymorphone; Peptides, Cyclic; Protein Binding; Protein Conformation; Receptors, Opioid, delta; Spiro Compounds; Structure-Activity Relationship | 1996 |
Induction of Fos-like immunoreactivity by opioids in guinea-pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Telencephalon | 1996 |
Effects of chronic administration of 7-benzylidene-7-dehydronaltrexone and naltriben on the antinociceptive actions of delta 1- and delta 2-opioid receptor agonists.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Enkephalins; Female; Membranes; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1996 |
Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.
Topics: Analgesics; Animals; Binding Sites; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Kidney; Kinetics; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Sensitivity and Specificity; Stimulation, Chemical; Transfection | 1996 |
Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1996 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Diprenorphine; Dogs; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Myocardium; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Sarcolemma; Virulence Factors, Bordetella | 1996 |
Opioid receptors on guinea-pig intestinal crypt epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding, Competitive; Cells, Cultured; Cyclic AMP; Endorphins; Enkephalins; Flow Cytometry; Guinea Pigs; Immunohistochemistry; Intestinal Absorption; Intestinal Mucosa; Intestines; Levorphanol; Male; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Stereoisomerism; Vasoactive Intestinal Peptide | 1996 |
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons; Nociceptors; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus | 1996 |
Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Brain Stem; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Solitary Nucleus; Stomach | 1996 |
Modulation of humoral immune response by central administration of leucine-enkephalin: effects of mu, delta and kappa opioid receptor antagonists.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antibody-Producing Cells; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hemolytic Plaque Technique; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
The importance of delta and kappa opioid receptors in the property of thyrotropin-releasing hormone against hemorrhagic shock.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Female; Heart Rate; Hemodynamics; Kinetics; Male; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Shock, Hemorrhagic; Thyrotropin-Releasing Hormone | 1997 |
Characterization of the decline in alcohol consumption by aminopeptidase inhibition.
Topics: Alcohol Drinking; Aminopeptidases; Angiotensin II; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drinking Behavior; Enkephalins; Imidazoles; Leucine; Losartan; Male; Naltrexone; Rats; Rats, Wistar; Tetrazoles | 1996 |
Determination of delta-opioid in NG108-15 cells.
Topics: Animals; Benzylidene Compounds; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured | 1997 |
Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Naltrexone; Narcotic Antagonists; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1997 |
Regulation of mu-opioid receptor in neural cells by extracellular sodium.
Topics: Adenylyl Cyclase Inhibitors; Amiloride; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extracellular Space; Humans; Intracellular Membranes; Monensin; Naltrexone; Neurons; Osmolar Concentration; Ouabain; Receptors, Opioid, mu; Sodium; Tumor Cells, Cultured | 1997 |
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.
Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared | 1997 |
Overexpression of delta-opioid receptors in recombinant baculovirus-infected Trichoplusia ni "High 5" insect cells.
Topics: Adenylyl Cyclases; Analgesics; Animals; Baculoviridae; Binding, Competitive; Blotting, Western; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunoblotting; Membrane Proteins; Mice; Naltrexone; Narcotic Antagonists; Ovary; Receptors, Opioid, delta; Recombinant Proteins; Spodoptera; Tritium; Viral Proteins | 1997 |
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors | 1997 |
Chronic morphine and naltrexone fail to modify mu-opioid receptor mRNA levels in the rat brain.
Topics: Animals; Brain; Corpus Striatum; DNA Primers; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome | 1997 |
Modulation of neurotransmitter release by opioid mu- and kappa-receptors from adrenergic terminals in the myenteric plexus of the guinea-pig colon: effect of alpha 2-autoreceptor blockade.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yohimbine | 1997 |
Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine.
Topics: Animals; Cryptococcus neoformans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Microglia; Morphine; Naltrexone; Narcotics; Phagocytosis; Swine | 1997 |
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Mice; Mice, Inbred C57BL; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neostigmine; Oligopeptides; Peptide Fragments | 1997 |
Opioids in the nucleus of the solitary tract are involved in feeding in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Male; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
[Cardioprotective effects of stimulation of peripheral mu-opiate receptors, and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage].
Topics: Animals; Cardiomyopathies; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immobilization; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu; Stress, Physiological | 1997 |
7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.
Topics: Analgesia; Analgesics; Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Ligands; Male; Mice; Mice, Inbred ICR; Molecular Structure; Muscle, Smooth; Naltrexone; Oxymorphone; Receptors, Opioid, delta; Spiro Compounds; Vas Deferens | 1997 |
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.
Topics: Animals; Benzamides; CHO Cells; Cloning, Molecular; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naltrexone; Narcotic Antagonists; Piperazines; Quinolines; Receptors, Opioid, delta; Sulfur Radioisotopes | 1997 |
Effects of some 7-arylidene and 7-heteroarylidene morphinan-6-ones on the antinociceptive activity of [D-Pen2, D-Pen5]enkephalin and [D-Ala2, Glu4]deltorphin II and on multiple opioid receptors.
Topics: Analgesics; Animals; Brain Chemistry; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Tissue Distribution; Vas Deferens | 1997 |
Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Vas Deferens | 1997 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalins; Iodine Radioisotopes; Kinetics; Models, Chemical; Naloxone; Naltrexone; Narcotic Antagonists; Organ Specificity; Peptides; Radioisotope Dilution Technique; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tissue Distribution | 1997 |
Antisense mapping of the MOR-1 opioid receptor clone: modulation of hyperphagia induced by DAMGO.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperphagia; Male; Naltrexone; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Effects of intracerebroventricular administration of beta-funaltrexamine on DAMGO-stimulated [35S]GTP-gamma-S binding in rat brain sections.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sulfur Radioisotopes | 1997 |
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon | 1997 |
Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Medulla Oblongata; Microinjections; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1997 |
Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects.
Topics: Animals; Benzylidene Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Sodium | 1997 |
Mutagenesis of the mouse delta opioid receptor converts (-)-buprenorphine from a partial agonist to an antagonist.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cells, Cultured; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Mice; Mutagenesis; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1998 |
Enkephalins modulate differentiation of normal human keratinocytes in vitro.
Topics: beta-Endorphin; Cell Differentiation; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Humans; Keratinocytes; Keratins; Melphalan; Naltrexone; Narcotic Antagonists; Skin; Transglutaminases | 1997 |
Proenkephalin gene regulation in the paraventricular nucleus by GABA: interactions with opioid systems in a transgenic model.
Topics: Aminooxyacetic Acid; Animals; beta-Galactosidase; Cells, Cultured; Enkephalins; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Humans; Hypothalamus; Mice; Mice, Transgenic; Muscimol; Naltrexone; Narcotic Antagonists; Organ Culture Techniques; Paraventricular Hypothalamic Nucleus; Protein Precursors; Recombinant Fusion Proteins; Saline Solution, Hypertonic; Stress, Physiological | 1998 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the central nucleus of the amygdala and in the paraventricular nucleus in the rat.
Topics: Amygdala; Animals; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections; Male; Naltrexone; Narcotic Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.
Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalins; Iodine Radioisotopes; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid | 1998 |
Structural features determining differential receptor regulation of neuronal Ca channels.
Topics: Analgesics; Barium; Benzeneacetamides; Calcium Channels; Cell Line; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Channel Gating; Mutagenesis; Naltrexone; Narcotic Antagonists; Neurons; Protein Structure, Tertiary; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Transfection | 1998 |
Estrogen-induced alteration of mu-opioid receptor immunoreactivity in the medial preoptic nucleus and medial amygdala.
Topics: Amygdala; Analgesics, Opioid; Animals; Antibody Specificity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Female; GTP-Binding Proteins; Naltrexone; Narcotic Antagonists; Opioid Peptides; Ovariectomy; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, Opioid, mu; Tritium | 1998 |
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice.
Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Macaca mulatta; Male; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa | 1998 |
Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens.
Topics: Animals; Dietary Carbohydrates; Dietary Fats; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Food Deprivation; Male; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
Chronic naltrexone differentially affects supraspinal delta-opioid receptor-mediated antinociception.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid, delta; Spinal Cord; Up-Regulation | 1998 |
The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats.
Topics: Aging; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1998 |
Role of central opioid receptor subtypes in morphine-induced alterations in peripheral lymphocyte activity.
Topics: Analgesics, Opioid; Animals; Brain; Cell Division; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Lymphocytes; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Quantitative immunolocalization of mu opioid receptors: regulation by naltrexone.
Topics: Analgesics, Opioid; Animals; Autoradiography; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium; Up-Regulation | 1998 |
The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys.
Topics: Animals; Azocines; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hot Temperature; Macaca mulatta; Male; Naltrexone; Pain; Receptors, Opioid, mu | 1998 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model.
Topics: Analgesics; Animals; Behavior, Animal; Disulfides; Drug Interactions; Enkephalins; Helplessness, Learned; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta | 1998 |
Role of central mu-opioid receptors in the modulation of nitric oxide production by splenocytes.
Topics: Analgesics; Analgesics, Opioid; Animals; Bacterial Toxins; Benzeneacetamides; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enterotoxins; Enzyme Inhibitors; Injections, Intraventricular; Lymphocytes; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Spleen; Superantigens | 1998 |
Association between the amygdala and nucleus of the solitary tract in mu-opioid induced feeding in the rat.
Topics: Amygdala; Animals; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Solitary Nucleus | 1998 |
Relationship between inhibitory effect of endogenous opioid via mu-receptors and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors | 1998 |
Contribution of the opioid system to alcohol aversion and alcohol drinking behavior.
Topics: Alcohol Drinking; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Ethanol; Female; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections.
Topics: Analgesics, Opioid; Animals; Brain; Caudate Nucleus; Cocaine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Heroin Dependence; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Opioid, mu; Self Administration | 1998 |
The effect of pentylenetetrazol kindling on synaptic mechanisms of interacting glutamatergic and opioid system in the hippocampus of rats.
Topics: Animals; Convulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Opioid; Seizures; Synapses | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence.
Topics: Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Dynamins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; Immunohistochemistry; Microscopy, Confocal; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Signal Transduction; Stimulation, Chemical | 1999 |
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 1998 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus | 1999 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
[Opiatergic mechanisms of cardioprotective and anti-arrhythmic effects of adaptation].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, Leucine; Epinephrine; Heart; Hypoxia; Immobilization; Male; Naltrexone; Narcotic Antagonists; Plant Extracts; Rats; Rats, Wistar | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection | 1998 |
Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ion Channel Gating; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1999 |
Growth inhibitory effects of a mu opioid on cultured cholinergic neurons from fetal rat ventral forebrain, brainstem, and spinal cord.
Topics: Analgesics, Opioid; Animals; Brain Stem; Cell Division; Cells, Cultured; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Prosencephalon; Rats; Rats, Wistar; Receptors, Opioid, mu; Respiration; Spinal Cord; Tritium | 1999 |
Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Solitary Nucleus; Stomach; Vagus Nerve | 1999 |
Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Pain; Receptors, Opioid, mu; Time Factors | 1999 |
Membrane microviscosity modulates mu-opioid receptor conformational transitions and agonist efficacy.
Topics: Animals; Cell Line; Cell Membrane; Cholesterol Esters; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Fluidity; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Conformation; Rats; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Tumor Cells, Cultured; Viscosity | 1999 |
Opioid receptor upregulation in mu-opioid receptor deficient CXBK and outbred Swiss Webster mice.
Topics: Analgesics; Animals; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Expression; Male; Mice; Mice, Mutant Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Up-Regulation | 1999 |
Effects of diethylstilbestrol on mouse hippocampal evoked potentials in vitro.
Topics: Animals; Binding, Competitive; Dactinomycin; Diethylstilbestrol; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Excitatory Postsynaptic Potentials; Hippocampus; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Pyramidal Cells; Receptors, Opioid; Receptors, Opioid, mu | 1999 |
Presynaptic kappa-opioid and muscarinic receptors inhibit the calcium-dependent component of evoked glutamate release from striatal synaptosomes.
Topics: 4-Aminopyridine; Animals; Calcium; Chelating Agents; Dicarboxylic Acids; Egtazic Acid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Neostriatum; Nerve Endings; Neurotransmitter Uptake Inhibitors; Potassium Channel Blockers; Potassium Channels; Pyrrolidines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Opioid, kappa; Receptors, Presynaptic; Synaptosomes | 1999 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
Opioid growth factor and organ development in rat and human embryos.
Topics: Animals; Brain; Brain Chemistry; DNA; Ectoderm; Embryonic and Fetal Development; Endoderm; Enkephalin, Methionine; Enkephalins; Female; Fetus; Gene Expression Regulation, Developmental; Heart; Humans; Immunohistochemistry; In Situ Hybridization; Intestines; Male; Mesoderm; Muscles; Myocardium; Naltrexone; Narcotic Antagonists; Pregnancy; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Ribs; RNA, Messenger; Skin; Tongue | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Analgesic effect of interferon-alpha via mu opioid receptor in the rat.
Topics: Analgesia; Animals; Antibodies, Monoclonal; Cell Line; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Injections, Intraventricular; Interferon Type I; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Proteins | 2000 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Cholera Toxin; Cyclic AMP; Dextrorphan; Enkephalin, Leucine-2-Alanine; Enkephalins; Epithelial Cells; Excitatory Amino Acid Antagonists; Fetus; Intestinal Secretions; Intestines; Kinetics; Levorphanol; Naltrexone; Narcotic Antagonists; Neprilysin; Protease Inhibitors; Rats; Receptors, Opioid, delta; Stereoisomerism; Thiorphan; Tritium | 2000 |
Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
Topics: Age Factors; Amnesia; Analgesics, Opioid; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Chickens; Chloramphenicol; Conditioning, Psychological; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Female; Male; Memory; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Protein Synthesis Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 2000 |
Modulation of humoral immune responses in the rat by centrally applied Met-Enk and opioid receptor antagonists: functional interactions of brain OP1, OP2 and OP3 receptors.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Hemolytic Plaque Technique; Immunoglobulins; Immunosuppressive Agents; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Characterization of opioid receptors modulating neurogenic contractions of circular muscle from porcine ileum and evidence that delta- and kappa-opioid receptors are coexpressed in myenteric neurons.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine; Goats; Ileum; In Vitro Techniques; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naltrexone; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Swine | 2001 |
Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Inflammation; Male; Microinjections; Naltrexone; Pain; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2001 |
Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cholecystokinin; Drug Tolerance; Enkephalin, Leucine; Excitatory Amino Acid Agonists; Male; Mice; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Spinal Cord | 2001 |
Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion.
Topics: Analgesia; Animals; Enkephalins; Formaldehyde; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Humans; Male; Naltrexone; Pain Measurement; Protein Precursors; Rats; Rats, Wistar; Simplexvirus; Transfection | 2001 |
Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.
Topics: Animals; Autonomic Nervous System; Cats; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gallbladder; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Neural Inhibition; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 2001 |
Alterations in central preproenkephalin mRNA expression after chronic free-choice ethanol consumption by fawn-hooded rats.
Topics: Amygdala; Animals; Brain; Dynorphins; Enkephalins; Ethanol; Gene Expression; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Olfactory Pathways; Protein Precursors; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Self Administration | 2001 |
Enkephalin release and opioid receptor activation does not mediate the antinociceptive or sedative/hypnotic effects of nitrous oxide.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalins; Genotype; Hypnotics and Sedatives; Immunohistochemistry; Male; Medulla Oblongata; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Neurons; Nitrous Oxide; Pain; Pain Measurement; Protein Precursors; Proto-Oncogene Proteins c-fos; Receptors, Opioid | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Roles of endogenous opioid peptides in modulation of nocifensive response to formalin.
Topics: Animals; Antibodies, Blocking; Dynorphins; Endorphins; Enkephalins; Formaldehyde; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Somatostatin; Spinal Cord | 2002 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation.
Topics: Brefeldin A; Cell Line; Endoplasmic Reticulum; Enkephalin, Leucine; Humans; Ligands; Molecular Chaperones; Naltrexone; Narcotic Antagonists; Protein Precursors; Protein Synthesis Inhibitors; Receptors, Opioid, delta | 2002 |
Crystal structure of biphalin sulfate: a multireceptor opioid peptide.
Topics: Binding Sites; Crystallography, X-Ray; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen Bonding; Naltrexone; Narcotics; Oligopeptides; Pliability; Protein Conformation; Protein Folding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Substrate Specificity; Tetrahydroisoquinolines | 2002 |
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus | 2002 |
Effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Dynorphins; Enkephalins; Female; Luteinizing Hormone; Naltrexone; Ovulation; Peptide Fragments; Proestrus; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cyclic AMP Response Element-Binding Protein; Depression; Dynorphins; Enkephalins; Helplessness, Learned; Immunohistochemistry; Male; Mice; Mice, Transgenic; Mutation; Naltrexone; Nucleus Accumbens; Prosencephalon; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.
Topics: Analgesia; Animals; Behavior, Animal; Cocaine; Drug Synergism; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Threshold; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Reward; Spatial Behavior; Stress, Physiological; Swimming | 2003 |
Involvement of mesolimbic structures in short-term sodium depletion: in situ hybridization and ligand-binding analyses.
Topics: Animals; Autoradiography; Corpus Striatum; Desoxycorticosterone; Diuresis; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Drinking; Dynorphins; Enkephalins; Furosemide; In Situ Hybridization; Limbic System; Male; Membrane Glycoproteins; Membrane Transport Proteins; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Nucleus Accumbens; Raclopride; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Sodium Chloride, Dietary; Sodium, Dietary; Thirst; Water | 2003 |
Leucine-enkephalin interrupts sympathetically mediated tachycardia prejunctionally in the canine sinoatrial node.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Bradycardia; Dogs; Enkephalin, Leucine; Female; Heart Rate; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Norepinephrine; Receptors, Opioid; Sinoatrial Node; Sympathetic Nervous System; Tachycardia; Vagus Nerve | 2003 |
Herpes virus-mediated preproenkephalin gene transfer in the ventral striatum mimics behavioral changes produced by olfactory bulbectomy in rats.
Topics: Animals; Basal Ganglia; Behavior, Animal; DNA, Complementary; Enkephalins; Gene Transfer Techniques; Herpesviridae; Male; Naltrexone; Narcotic Antagonists; Olfactory Bulb; Olfactory Pathways; Protein Precursors; Psychomotor Agitation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2003 |
Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices.
Topics: Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; Female; Male; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Tetrodotoxin; Time Factors | 2003 |
The expression and function of the OGF-OGFr axis - a tonically active negative regulator of growth - in COS cells.
Topics: Animals; Cell Division; COS Cells; Enkephalins; Gene Expression; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Protein Precursors; Receptors, Opioid | 2003 |
Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin.
Topics: Administration, Cutaneous; Animals; Enkephalins; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herpesviridae; Hyperalgesia; Immunohistochemistry; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Pertussis Toxin; Protein Precursors; Receptors, Opioid, mu; Receptors, sigma; Somatostatin | 2004 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Opioid receptors and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
Topics: Alkaline Phosphatase; Benzamides; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mutation; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Structure-Activity Relationship | 2005 |
Delta-opioid receptor antagonists exhibit properties of partial delta-receptor agonists in isolated perfused heart.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Naltrexone; Oligopeptides; Perfusion; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta | 2004 |
Anti-inflammatory and opioid-mediated effects of melatonin on experimental peritonitis in chickens.
Topics: Adjuvants, Immunologic; Animals; beta-Endorphin; Cell Proliferation; Chickens; Disease Models, Animal; Enkephalins; Gene Expression; Macrophages, Peritoneal; Male; Melatonin; Naltrexone; Narcotic Antagonists; Opioid Peptides; Peritonitis; Pro-Opiomelanocortin; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen; Thioglycolates | 2005 |
Functional mu opioid receptors are expressed in cholinergic interneurons of the rat dorsal striatum: territorial specificity and diurnal variation.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Blotting, Northern; Choline O-Acetyltransferase; Circadian Rhythm; Corpus Striatum; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; Immunohistochemistry; In Vitro Techniques; Interneurons; Limbic System; Membrane Potentials; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Potassium; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptosomes; Tritium | 2005 |
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin | 2005 |
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors | 2005 |
Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Enkephalins; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Social Behavior; Stress, Psychological | 2006 |
Affinity identification of delta-opioid receptors using latex nanoparticles.
Topics: Animals; Chemistry, Pharmaceutical; CHO Cells; Cricetinae; Cytosol; Enkephalins; Latex; Models, Chemical; Naltrexone; Nanostructures; Protein Binding; Receptors, Opioid; Receptors, Opioid, delta; Recombinant Proteins | 2006 |
Subclass opioid receptors associated with the cardiovascular depression after traumatic shock and the antishock effects of its specific receptor antagonists.
Topics: Animals; Blood Pressure; Cardiovascular System; Enkephalin, Leucine; Femur; Free Radicals; GABA Modulators; Hemodynamics; Models, Statistical; Naltrexone; Narcotic Antagonists; Pentobarbital; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Shock; Time Factors | 2005 |
Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Hot Temperature; Male; Memory; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Pain Measurement; Protein Precursors; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2006 |
Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Male; Mice; Mice, Knockout; Morpholines; Naltrexone; Naphthalenes; Protein Precursors; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Self Administration | 2006 |
Involvement of delta1-opioid receptors in the spatial learning impairment in streptozotocin-induced diabetic mice.
Topics: Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Enkephalins; Escape Reaction; Mice; Naltrexone; Reaction Time; Receptors, Opioid, delta; Space Perception | 2005 |
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cell Line; Cell Nucleus; DNA; Dynorphins; Electrophoretic Mobility Shift Assay; Enkephalins; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Insulin-Secreting Cells; Islets of Langerhans; Kv Channel-Interacting Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Binding; Protein Precursors; Receptors, Opioid, kappa; Repressor Proteins | 2006 |
The role of delta opioid receptors in the anxiolytic actions of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Enkephalins; Male; Maze Learning; Naltrexone; Rats; Rats, Long-Evans; Receptors, GABA-A; Receptors, Opioid, delta | 2006 |
Effect of prolonged progesterone treatment on the proenkephalin mRNA gene expression and enkephalins concentration in the sheep brain.
Topics: Animals; Enkephalins; Estrous Cycle; Female; Gene Expression Regulation; Hypothalamus; Naltrexone; Opioid Peptides; Pituitary Gland; Poland; Progesterone; Protein Precursors; RNA, Messenger; Sheep | 2006 |
Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzamides; Cell Count; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Temporal Lobe; Guanidines; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Nerve Degeneration; Piperazines; Protein Precursors; Receptors, Opioid, kappa; Synaptic Transmission; Time Factors | 2007 |
Central inhibition of opioid receptor subtypes and its effect on haemorrhagic hypotension in conscious sheep.
Topics: Animals; Bradycardia; Enkephalin, Leucine; Hemorrhage; Hypotension; Injections, Intraventricular; Models, Animal; Naltrexone; Narcotic Antagonists; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regional Blood Flow; Renal Circulation; Sheep | 2007 |
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
Topics: Acid Sensing Ion Channels; Analgesics; Animals; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Membrane Proteins; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Pain; Pain Measurement; Peptides; Protein Precursors; Reaction Time; Sodium Channels; Spider Venoms; Spinal Cord; Time Factors | 2007 |
Two-photon excitation fluorescence cross-correlation assay for ligand-receptor binding: cell membrane nanopatches containing the human micro-opioid receptor.
Topics: Animals; Cell Line; Cell Membrane; Cross-Linking Reagents; Enkephalin, Leucine; Fluorescein; Humans; Ligands; Molecular Structure; Naloxone; Naltrexone; Nanostructures; Narcotic Antagonists; Photons; Quantum Dots; Receptors, Opioid; Solutions; Spodoptera; Titrimetry | 2007 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2007 |
Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Drug Synergism; Drug Therapy, Combination; Drug Tolerance; Enkephalins; Excitatory Amino Acid Antagonists; Hot Temperature; Injections, Spinal; Ketamine; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Tail | 2008 |
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Conditioning, Operant; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Odorants; Phosphorylation; Protein Precursors; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Urocortins | 2008 |
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.
Topics: Analgesics, Opioid; Animals; Down-Regulation; Electrophysiology; Enkephalins; Etorphine; Fentanyl; In Vitro Techniques; Male; Naltrexone; Oxymorphone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2008 |
Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation.
Topics: Analgesics, Opioid; Animals; Endorphins; Enkephalins; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardium; Naltrexone; Norepinephrine; Peptide Fragments; Peptides; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Somatostatin | 2008 |
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Brain Stem; Corticosterone; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Exploratory Behavior; Female; Guanidines; Hypothalamus; Male; Maze Learning; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Neuropeptide Y; Neuropeptides; Protein Precursors; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Novel role for the delta-opioid receptor in hypoxic preconditioning in rat retinas.
Topics: Animals; Antioxidants; Blotting, Western; Dinoprost; Enkephalin, Leucine; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Intraocular Pressure; Ischemic Preconditioning; Lipid Peroxidation; Male; Naltrexone; Narcotic Antagonists; Oxidative Stress; Rats; Rats, Wistar; Receptors, Opioid, delta; Retina; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Spectrometry, Fluorescence; Superoxides | 2009 |
Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Indoles; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Opioid, delta; Receptors, Opioid, kappa; RNA, Messenger | 2009 |
Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Enkephalins; Gene Expression Regulation; Immobility Response, Tonic; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, kappa; Recognition, Psychology; Stress, Psychological; Swimming; Time Factors | 2009 |
Delta opioid receptor-mediated immunoregulatory role of methionine-enkephalin in freshwater teleost Channa punctatus (Bloch.).
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Fishes; Fresh Water; Male; Methionine; Naltrexone; Nitrites; Phagocytes; Phagocytosis; Receptors, Opioid, delta; Spleen; Superoxides | 2009 |
Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.
Topics: Amphetamine-Related Disorders; Animals; Behavior, Animal; Brain; Choice Behavior; Conditioning, Classical; Enkephalins; Gene Expression; Hallucinogens; Mice; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Narcotic Antagonists; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, delta; RNA, Messenger; Social Environment; Transcription, Genetic | 2009 |
Central administration of somatostatin stimulates feeding behavior in chicks.
Topics: Alkylating Agents; Animals; Animals, Newborn; Chickens; Eating; Enkephalin, Leucine; Hormones; Male; Naltrexone; Narcotic Antagonists; Neuropeptides; Receptors, Opioid; Somatostatin | 2009 |
Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Area Under Curve; Blotting, Western; Dopamine; Enkephalins; Gene Expression; Genes, fos; Mice; Mice, Knockout; Microdialysis; Motor Activity; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Substance Withdrawal Syndrome | 2009 |
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors | 2010 |
Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity.
Topics: Action Potentials; Animals; Cholecystokinin; Dehydration; Electrophysiology; Enkephalins; Female; Hypernatremia; Hyponatremia; Immunohistochemistry; In Situ Hybridization; Naltrexone; Narcotic Antagonists; Neurons; Oxytocin; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger; Vasopressins | 2009 |
Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Psychological; Cues; Enkephalins; Gene Expression Regulation; Genotype; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phenotype; Protein Precursors; Receptors, Opioid, kappa; Reward; RNA, Messenger; Species Specificity | 2010 |
Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Conditioning, Psychological; Enkephalins; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Precursors; Receptors, Opioid, kappa; Reward; Self Administration; Signal Transduction; Stress, Physiological | 2010 |
Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward.
Topics: Amygdala; Animals; Conditioning, Operant; Drive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Food; Guanidines; Male; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Somatostatin; Sucrose | 2011 |
The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.
Topics: Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System | 2011 |
Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model.
Topics: Apoptosis; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Enkephalins; Humans; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2011 |
Neuroprotective potential of biphalin, multireceptor opioid peptide, against excitotoxic injury in hippocampal organotypic culture.
Topics: Animals; Enkephalins; Excitatory Amino Acid Agents; Hippocampus; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Opioid, delta | 2011 |
The role of endogenous dynorphin in ethanol-induced state-dependent CPP.
Topics: Animals; Central Nervous System Depressants; Conditioning, Operant; Drug Administration Schedule; Dynorphins; Enkephalins; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Protein Precursors; Sex Factors; Time Factors | 2012 |
Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats.
Topics: Analgesics; Animals; Cardiovascular System; Enkephalins; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Respiratory System | 2011 |
Hypoxic preconditioning attenuates global cerebral ischemic injury following asphyxial cardiac arrest through regulation of delta opioid receptor system.
Topics: Animals; Apoptosis; Arousal; Asphyxia; Behavior, Animal; Blotting, Western; Brain Ischemia; Brain Stem; Enkephalin, Leucine; Fluorescent Antibody Technique; Heart Arrest; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; In Situ Nick-End Labeling; Ischemic Preconditioning; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Postural Balance; Rats; Real-Time Polymerase Chain Reaction; Receptors, Opioid, delta; RNA, Small Interfering; Seizures; Survival Analysis | 2012 |
Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enkephalins; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Mice; Mice, Nude; Naltrexone; Neoplasm Transplantation; Ovarian Neoplasms; Receptors, Opioid; Time Factors | 2012 |
Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood.
Topics: Animals; Behavior, Animal; Brain; Delayed-Action Preparations; Dynorphins; Enkephalins; Female; Gene Expression; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neostriatum; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration | 2012 |
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalins; Fentanyl; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Dynorphins regulate the strength of social memory.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Enkephalins; Hippocampus; Memory; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, kappa; Recognition, Psychology; Social Behavior | 2014 |
Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.
Topics: Animals; Anxiety; Catheterization; Conditioning, Operant; Enkephalins; Heroin Dependence; Immunohistochemistry; Male; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome | 2013 |
Spinal ERK2 activation through δ2-opioid receptors contributes to nociceptive behavior induced by intrathecal injection of leucine-enkephalin.
Topics: Animals; Arginine; Behavior, Animal; Butadienes; Enkephalin, Leucine; Enzyme Activation; Glycopeptides; Injections, Spinal; Leucine; Male; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Nociception; Protease Inhibitors; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Spinal Cord | 2014 |
Desensitization of functional µ-opioid receptors increases agonist off-rate.
Topics: Analgesics, Opioid; Animals; Brain; Enkephalins; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kinetics; Ligands; Naloxone; Naltrexone; Photolysis; Potassium; Rats; Receptors, Opioid, mu | 2014 |
Cellular localization and adaptive changes of the cardiac delta opioid receptor system in an experimental model of heart failure in rats.
Topics: Adaptation, Physiological; Animals; Binding, Competitive; Calcium Channels, L-Type; Disease Models, Animal; Enkephalins; Heart Failure; Ligands; Male; Myocardium; Naltrexone; Protein Binding; Protein Precursors; Radioligand Assay; Rats, Wistar; Receptors, Opioid, delta; Ryanodine Receptor Calcium Release Channel; Stroke Volume; Ventricular Function, Left | 2016 |
Enkephalin analog, cyclo[N(ε),N(β)-carbonyl-D-Lys(2),Dap(5)] enkephalinamide (cUENK6), inhibits the ethanol withdrawal-induced anxiety-like behavior in rats.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Enkephalin, Leucine; Enkephalins; Ethanol; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2015 |
κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake.
Topics: Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, Operant; Enkephalins; Male; Methamphetamine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration | 2015 |
Mu opioid receptor modulation in the nucleus accumbens lowers voluntary wheel running in rats bred for high running motivation.
Topics: Analgesics, Opioid; Animals; Animals, Outbred Strains; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Motivation; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Rats, Wistar; Receptors, Opioid, mu; RNA, Messenger; Running; Species Specificity | 2015 |
Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.
Topics: Drug Inverse Agonism; Enkephalin, Leucine; Halogenation; Humans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Recombinant Proteins | 2015 |
Antagonism of κ opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Male; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; RNA, Messenger; Substance Withdrawal Syndrome | 2015 |
Opioid-dependent regulation of high and low fear responses in two inbred mouse strains.
Topics: Amygdala; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Enkephalins; Fear; Gene Expression; Genetic Association Studies; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Protein Precursors; Random Allocation; Receptors, Opioid; Stress, Psychological | 2015 |
Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI).
Topics: Analgesics; Analysis of Variance; Animals; Anxiety; Brain Injuries; Cognition Disorders; Disease Models, Animal; Enkephalins; Exploratory Behavior; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Recognition, Psychology; Silver Staining | 2016 |
Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Nociception; Receptors, Opioid, delta; Spinal Cord | 2016 |
Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin.
Topics: Analgesics; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Enkephalins; Hippocampus; Male; Maze Learning; Memory, Long-Term; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Rats, Wistar; Saccharin | 2021 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |