enkephalin, leucine has been researched along with naloxone in 1559 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1014 (65.04) | 18.7374 |
| 1990's | 442 (28.35) | 18.2507 |
| 2000's | 72 (4.62) | 29.6817 |
| 2010's | 25 (1.60) | 24.3611 |
| 2020's | 6 (0.38) | 2.80 |
| Authors | Studies |
|---|---|
| Kullmann, W | 1 |
| Aguzzi, A; Benke, D; Gao, B; Hagenbuch, B; Kullak-Ublick, GA; Meier, PJ | 1 |
| Cassel, JA; Chung, NN; Daubert, JD; DeHaven, RN; Goodman, M; Schiller, PW; Schlechtingen, G; Taulane, JP | 1 |
| Henderson, RS | 1 |
| Henderson, G; Hughes, J; Kosterlitz, HW; Smokcum, RW; Waterfield, AA | 1 |
| Gardier, RW | 1 |
| Cieszkowski, M; Coy, DH; Jaworek, J; Konturek, SJ; Schally, AV; Tasler, J | 1 |
| Klee, WA; Knight, M | 1 |
| Besson, JM; Le Bars, D; Oliveras, JL | 1 |
| Brown, B; Dettmar, PW; Dobson, PR; Lynn, AG; Metcalf, G; Morgan, BA | 1 |
| Segal, DS | 1 |
| Browne, RG; Derrington, DC; Segal, DS | 1 |
| Neuhoff, V; Osborne, NN | 1 |
| Belluzzi, JD; Stein, L | 4 |
| Kromer, W | 2 |
| Keane, PE; Neal, H | 1 |
| Leslie, RD; Pyke, DA; Stubbs, WA | 1 |
| Arrigo Reina, R; Ferri, S; Santagostino, A; Scoto, GM; Spadaro, C | 1 |
| Ertel, N; Manougian, A; May, P; Mittler, J | 1 |
| Dunai-Kovács, Z; Miglécz, E; Székely, JI | 1 |
| Dzoljic, MR; van der Lely, AJ; von Mourik, JB | 1 |
| Calne, DB; Chase, TN; Eisler, T; Nutt, JG; Rosin, AJ | 1 |
| Costa, E; Dill, RE | 1 |
| Hughes, J; Kosterlitz, HW; Lord, JA; Waterfield, AA | 1 |
| Bauer, W; Buescher, HH; Cardinaux, F; Closse, A; Hauser, D; Hill, RC; Huguenin, R; Pless, J; Roemer, D | 1 |
| Simantov, R; Snyder, SH | 1 |
| Terenius, L | 3 |
| Duncalf, D; Fishman, J; Foldes, FF; Hahn, EF; Nagashima, H; Shiwaku, Y | 1 |
| Eberle, A; Fauchère, JL; Leukart, O; Schiller, P; Schwyzer, R | 1 |
| Pert, A; Simantov, R; Snyder, SH | 1 |
| Brandt, M; Glaser, T; Hamprecht, B; Klebensberger, W; Traber, J | 1 |
| Chau-Pham, TT; Dewey, WL | 1 |
| Blume, AJ; Finberg, JP; Shorr, J; Spector, S | 1 |
| Guillemin, R | 1 |
| Burgis, V; Edwards, JD; Frederickson, RC; Harrell, CE | 1 |
| Barker, JL; Macdonald, RL; Neale, JH; Smith, TG | 1 |
| Childers, SR; Simantov, R; Snyder, SH | 1 |
| Frenk, H; Liebeskind, JC; McCarty, BC | 1 |
| Biggio, G; Casu, M; Corda, MG; Di Bello, C; Gessa, GL | 1 |
| Childers, SR; Coyle, JT; Schwarcz, R; Snyder, SH | 1 |
| Frenk, H; Liebeskind, JC; Urca, G | 1 |
| Frederickson, RC; Huang, SP; Rudy, TA; Yaksh, TL | 1 |
| Goldstein, A | 1 |
| Blume, AJ | 1 |
| Coy, DH; Konturek, SJ; Pawlik, W; Schally, AV; Waluś, KM | 1 |
| Mashkovskiĭ, MD | 1 |
| Henry, JL; Lal, S; Tan, AT; Tsang, D | 1 |
| Champagnat, J; Denavit-Saubié, M; Zieglgänsberger, W | 1 |
| Ikezono, E; Kumazawa, T; Matsumoto, I; Watanabe, Y | 1 |
| Gumułka, W; Rowerski, W | 1 |
| Hoffer, BJ; Morris, DH; Palmer, MR; Stewart, JM; Taylor, DA | 1 |
| Haigler, HJ; Spring, DD | 1 |
| Dostrovsky, JO; Hu, JW; Sessle, BJ | 1 |
| Borison, RL; Diamond, BI | 1 |
| Makman, MH; Walczak, SA; Wilkening, D | 1 |
| Gallagher, M; Kapp, BS | 1 |
| Basbaum, AI; Fields, HL | 1 |
| Arimura, A; Chihara, K; Coy, DH; Schally, AV | 1 |
| Aghajanian, GK; Guyenet, PG | 1 |
| Fry, JP; Herz, A; Zieglgänsberger, W | 2 |
| Katayama, Y; North, RA; Williams, JT | 1 |
| Stein, L | 1 |
| Ackermann, RF; Engel, J; Frenk, H; Liebeskind, JC; Shavit, Y | 1 |
| Meunier, JC; Zajac, JM | 1 |
| Akaike, A; Satoh, M; Takagi, H | 1 |
| Tulloch, IF; Zieglgänsberger, W | 1 |
| Khazan, N; Moreton, JE; Tortella, FC | 1 |
| Arancibia, S; Enjalbert, A; Kordon, C; Priam, M; Ruberg, M | 1 |
| Aliautdin, RN; Chichenkov, ON; Fisenko, VP | 1 |
| Meldrum, BS; Menini, C; Naquet, R; Stutzmann, JM | 1 |
| Appelboom, T; Famaey, JP; Govaerts, A; Wybran, J | 1 |
| Huidobro, F; Huidobro-Toro, JP; Miranda, H | 1 |
| Davis, LG; Ehrlich, YH | 1 |
| Hiripi, L; Stefano, GB | 1 |
| Kawajiri, SI; Satoh, M; Ukai, Y; Yamamoto, M | 1 |
| Ferreira, SH; Nakamura, M | 3 |
| Coy, DH; Kastin, AJ; Olson, GA; Olson, RD | 1 |
| Satake, N | 2 |
| Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE; Sosa, RP | 1 |
| Extein, I; Goodwin, FK; Lo, C; Schoenfeld, RI | 1 |
| Giagnoni, G; Nirenberg, M; Sabol, SL | 1 |
| Bloom, FE; Guillemin, R; Ling, N; Nicoll, RA; Siggins, GR | 1 |
| Bloom, FE; Guillemin, R; Henriksen, SJ; Ling, N; McCoy, F | 1 |
| Bläsig, J; Cording, C; Emrich, HM; Herz, A; Kölling, A; Pirée, S; von Zerssen, D | 1 |
| Drouva, SV; Kordon, C; Pattou, E; Rotsztejn, WH | 1 |
| Szontágh, L; Telegdy, G; Vermes, I | 1 |
| Duggan, AW | 3 |
| Herz, A | 1 |
| Bunting, PB; Clineschmidt, BV; McGuffin, JC | 1 |
| North, RA; Williams, JT | 1 |
| Elazar, Z; Ely, Y; Motles, E; Simantov, R | 1 |
| Broekkamp, CL; Cools, AR; Phillips, AG | 1 |
| Gessa, GL; Paglietti, E; Quarantotti, BP | 1 |
| den Hertog, A; Huizinga, JD | 1 |
| Croxatto, R; Huidobro, F; Huidobro-Toro, JP | 1 |
| Sastry, BR | 1 |
| Duggan, AW; Griersmith, BT; Hall, JG; Headley, PM | 1 |
| Frederickson, RC; Richter, JA; Wesche, DL | 1 |
| Kosterlitz, HW; Leslie, FM | 1 |
| Catapane, EJ; Stefano, GB | 1 |
| Göthert, M; Pohl, IM; Wehking, E | 1 |
| Huidobro-Toro, JP; Way, EL | 3 |
| Downs, DA; Wiley, JN | 1 |
| Bajusz, S; Gráf, L; Szebeni, A; Wollemann, M | 1 |
| Bhargava, HN | 3 |
| Creager, R; Jensen, RA; Lynch, G; Martinez, JL; McGaugh, JL; Messing, RB; Veliquette, J | 1 |
| Takemori, AE; Vaught, JL | 1 |
| Johansson, P; Josefsson, JO | 1 |
| Beubler, E; Lembeck, F | 1 |
| Broekkamp, CL; Phillips, AG | 1 |
| Gudelsky, GA; Porter, JC | 1 |
| Bajorek, JG; Chesarek, W; Felmar, M; Lomax, P | 1 |
| Battista, AF; Matsumoto, Y; Shigemori, M; Watanabe, M | 1 |
| Bäuerle, U; Bläsig, J; Herz, A | 1 |
| Gurevich, N; Pomeranz, B | 1 |
| Coy, DH; Kastin, AJ; Lahoste, GJ; Olson, GA; Olson, RD | 1 |
| Pert, A; Sivit, C | 1 |
| Feldberg, W; Smyth, DG | 1 |
| Burgis, V; Edwards, JD; Frederickson, RC | 1 |
| Berney, S; Hornykiewicz, O | 1 |
| Ho, WK; Lam, S; Ma, L; Wen, HL | 1 |
| Li, CH; Loh, HH; Tseng, LF | 1 |
| Altstetter, R; Bergmann, F; Weissman, BA | 1 |
| Amano, H; Shiomi, H; Takagi, H; Ueda, H | 1 |
| Duggan, AW; Hall, JG; Headley, PM | 1 |
| Jaques, R | 1 |
| Flórez, J; Mediavilla, A | 1 |
| Childers, SR; Snyder, SH | 1 |
| Bisset, GW; Chowdrey, HS; Feldberg, W | 1 |
| Friesen, H; Havlicek, V; LaBella, FS; Leybin, L; Rezek, M | 1 |
| Agnati, LF; Bolme, P; Bradley, R; Fuxe, K; Smythies, J | 1 |
| Clark, DE; Lien, EL; McGregor, WH | 1 |
| Carney, JM; Rosecrans, JA | 1 |
| Shaw, JS; Turnbull, MJ | 1 |
| Cowie, AT; Hart, IC | 1 |
| Carney, JM; Day, AR; Dewey, WL; Freer, RJ; Rosecrans, JA | 1 |
| Eger, EI; Harper, MH; Johnson, BH; Winter, PM | 1 |
| Baldrighi, G; Carroll, BJ; Katz, RJ | 1 |
| Miletić, V; Randić, M | 1 |
| Abe, H; Imura, H; Iwasaki, Y; Kato, Y; Ohgo, S | 1 |
| Biggio, G; Corda, MG; Gessa, GL; Paglietti, E; Quarantotti, BP | 1 |
| Bradley, PB; Gayton, RJ; Lambert, LA | 1 |
| Bajorek, JG; Chesarek, W; Felmer, M; Lomax, P | 1 |
| Chipkin, RE; Crowley, TJ; Morris, DH; Stewart, JM | 1 |
| Law, PY; Loh, HH | 1 |
| Achilli, G; Algeri, A; Calderini, G; Canas, EP; Consolazione, A; Garattini, S | 1 |
| Kalat, JW | 1 |
| Bajusz, S; Dunai-Kovács, Z; Miglécz, E; Rónai, AZ; Székely, JI | 1 |
| Coy, DH; Kastin, AJ; Meyers, CA; Schally, AV | 1 |
| Chipkin, RE; Morris, DH; Stewart, JM | 1 |
| Akera, T; Brody, TM; Davis, ME | 1 |
| Gelbart, J; Katz, RJ | 1 |
| Huang, JT; Lajtha, A | 1 |
| Clark, WG | 2 |
| Meunier, JC; Moisand, C | 1 |
| Frenk, H; Liebeskind, JC; Taylor, AN; Urca, G | 1 |
| Cocchi, D; Ferri, S; Gil-Ad, I; Müller, EE; Santagostino, A | 1 |
| Bird, SJ; Kuhar, MJ; Young, WS | 1 |
| Li, CH; Loh, HH; Tseng, LF; Wei, ET | 1 |
| Bruni, JF; Marshall, S; Meites, J; Van Vugt, D | 1 |
| Hosein, EA; Lapalme, M; Vadas, EB | 1 |
| Jhamandas, K; Sawynok, J; Sutak, M | 1 |
| Dininger, NB; Frederickson, RC; Jackson, L; Shaar, CJ | 1 |
| Huang, SP; Rudy, TA; Yaksh, TL | 1 |
| Berggren, A; Rubenson, A; Sillén, U | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M; Mantelet, S; Mauborgne, A | 1 |
| Di Giulio, AM; Donadoni, ML; Finco, C; Germani, E; Gorio, A; Malosio, ML; Mantegazza, P; Tenconi, B | 1 |
| Khugaeva, VK | 2 |
| Costa, EM; Hoffmann, BB; Loew, GH | 1 |
| Jivegård, L; Moreau, J; Pollard, H; Schwartz, JC; Svanvik, J; Thune, A | 1 |
| Gintzler, AR; Xu, H | 2 |
| Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L | 1 |
| McDonald, JS; Rattan, AK; Tejwani, GA | 1 |
| Halter, JB; Kiritsy-Roy, JA; Smith, MJ; Terry, LC | 1 |
| Pinnock, RD | 2 |
| Madamba, S; Siggins, GR; Yuan, XR | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Haberstok, H; Hrsak, I; Marotti, T; Sverko, V | 1 |
| Green, PG; Levine, JD | 1 |
| Crook, TJ; Hill, RG; Kitchen, I | 1 |
| Childers, SR; Nijssen, PC; Sexton, T | 1 |
| Chaki, K; Kisara, K; Nakata, N; Sakurada, S; Sakurada, T; Suzuki, K; Watanabe, H | 1 |
| Finberg, RW; Heagy, W; Shipp, MA | 1 |
| Balboa, JL; Belmonte, A; Castaño, MT; Freire-Garabal, M; Núñez, MJ | 1 |
| Mosberg, HI; Porreca, F; Raffa, RB; Wild, KD | 1 |
| Edwards, RH; Evans, CJ; Keith, DE; Magendzo, K; Morrison, H | 1 |
| Armstead, WM; Crofton, JT; Leffler, CW; Mirro, R; Share, L; Zuckerman, SL | 1 |
| Erspamer, GF; Erspamer, V; Melchiorri, P; Negri, L; Potenza, RL; Severini, C | 1 |
| Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE | 1 |
| Baumeister, AA; Hurry, MJ; Richard, AL; Richmond-Landeche, L; Waguespack, AM | 1 |
| Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Hylden, JK; Kitto, K; Lei, S; Roerig, SC; Wilcox, GL | 1 |
| Austin, MC; Churchill, L; Kalivas, PW | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N | 1 |
| Bhattacharya, SK; Saraswati, M; Sen, AP | 1 |
| Dora, E; Hines, K; Kunos, G; McLaughlin, AC | 1 |
| Han, JS; Ren, MF; Sun, XJ; Wang, JF; Yang, HF | 1 |
| Cottrell, GA; Meyer, ME; van Hartesveldt, C | 1 |
| Rabkin, SW | 1 |
| Fournie-Zaluski, MC; Noble, F; Roques, BP; Soleilhac, JM; Soroca-Lucas, E; Turcaud, S | 1 |
| Abe, I; Fujishima, M; Kobayashi, K; Matsumura, K; Tominaga, M; Tsuchihashi, T | 1 |
| Han, JS; Ma, QP; Shi, YS | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Holman, RB; Widdowson, PS | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Froehlich, JC; Harts, J; Li, TK; Lumeng, L; Zweifel, M | 1 |
| Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP | 1 |
| Randić, M; Rusin, KI | 1 |
| Chalmers, J; Drolet, G; Morilak, DA | 1 |
| Gulya, K; Kása, P; Kovács, GL | 1 |
| Abdelhamid, EE; Takemori, AE | 1 |
| Kaneto, H; Kawasaki, K; Kobayashi, Y; Maeda, M; Shimokawa, K; Taguchi, T; Takahashi, M; Tokuyama, S; Watanabe, J; Yamamoto, Y | 1 |
| Drukarch, B; Mulder, AH; Ruuls, SR; Schoffelmeer, AN; Van Vliet, BJ | 1 |
| Chiba, S; Nishida, N; Yasuhara, Y | 1 |
| Campus, MP; Capogrossi, MC; Lakatta, EG; Sisini, A; Ventura, C | 1 |
| Bilotta, JM; Brackeen, MF; Feldman, PL; James, MK; Leighton, HJ; Schuster, SV | 1 |
| Cagampang, FR; Maeda, K | 1 |
| Jessop, JJ; Taplits, MS | 1 |
| Matsuyama, S; Nakayama, S; Sano, I; Takeda, K; Tanaka, C; Taniyama, K; Yoshihara, C | 1 |
| Basbaum, AI; Gogas, KR; Levine, JD; Presley, RW | 1 |
| Fadda, P; Fratta, W; Tortorella, A | 1 |
| Gratton, A; Pentney, RJ | 1 |
| Barnes, NM; Bunce, KT; Naylor, RJ; Rudd, JA | 1 |
| Hawkins, M; Stein, EA | 1 |
| Gromov, LA; Krivorotov, SV | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Schoffelmeer, AN | 1 |
| Lu, CL; Shaikh, MB; Siegel, A | 1 |
| Lishmanov, IuB; Maslov, LN | 1 |
| Schmidt, PF; Schomburg, ED; Steffens, H | 1 |
| Cheng, J; Pasternak, GW; Paul, D; Pick, CG | 1 |
| Bramham, CR; Milgram, NW; Srebro, B | 1 |
| Collins, JG; Kitahata, LM; Nakagawa, I; Nakatani, K; Omote, K | 2 |
| Hattori, Y; Katafuchi, T; Koizumi, K | 1 |
| Olianas, MC; Onali, P | 1 |
| Casellas, AM; Guardiola, H; Renaud, FL | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN; Warden, G | 1 |
| Harrison, NL; Lambert, NA; Teyler, TJ | 1 |
| Shiotsu, G; Stein, L; Stevens, KE | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Michaelson, DM; Oron, L; Sarne, Y | 1 |
| Hammond, C; Henderson, G; Seward, E | 1 |
| Kangrga, I; Randić, M | 1 |
| Bishop, GA | 1 |
| Duckles, SP; Li, YJ | 1 |
| Ida, G | 1 |
| Helme, RD; Khalil, Z | 1 |
| Christofi, FL; Cook, MA; McDonald, TJ | 1 |
| Blais, DP; de Groat, WC; Erdman, S; Kawatani, M; Thor, KB | 1 |
| Jones, AJ; Keen, P; Ray, NJ | 1 |
| Shimada, Y; Yamada, K; Yoshida, S | 1 |
| Janson, VE; Owens, LK; Sastry, BV | 1 |
| Antica, M; Gabrilovac, J; Osmak, M | 1 |
| Azerad, J; Desmonts, JM; Limoge, A; Mantz, J | 1 |
| Burks, TF; Davis, TP; Greene, DL; Hersh, LB; Hruby, VJ; Kramer, TH; Sharma, SD; Weber, SJ; Yamamura, HI | 1 |
| Adler, MW; Eisenstein, TK; Geller, EB; Rogers, TJ; Taub, DD | 1 |
| Barron, BA; Caffrey, JL; Gaugl, JF; Gu, H | 1 |
| Huang, XD; Wong, TM | 1 |
| Butt, W; Cowan, A; Fisher, RS; Krevsky, B; Maurer, AH | 1 |
| Pasternak, GW; Paul, D; Pick, CG | 1 |
| Bagetta, G; De Sarro, GB; Nisticò, G; Rispoli, V; Sakurada, S | 1 |
| Asanuma, M; Ogawa, N; Ota, Z; Takayama, H | 1 |
| Burnstock, G; Hoyle, CH; Kamm, MA; Lennard-Jones, JE | 1 |
| Gramsch, C; Hassan, AH; Herz, A; Parsons, CG; Peter, K; Przewlocki, R; Stein, C | 1 |
| Giuliani, S; Maggi, CA; Meli, A | 2 |
| Alberch, J; Arenas, E; Marsal, J; Sanchez Arroyos, R | 1 |
| Kelly, MJ; Loose, MD; Ronnekleiv, OK | 2 |
| Kawabata, A; Sasa, M; Takaori, S; Ujihara, H | 1 |
| Belcheva, S; Kosteljanetz, N; Kupenova, P; Popova, E; Vitanova, L | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Hishida, F; Igarashi, O; Luo, CP; Takeshige, C | 1 |
| Baldwin, BA; de la Riva, C; Ebenezer, IS | 1 |
| Collins, KA; Tseng, LF | 1 |
| Fournié-Zaluski, MC; Noble, F; Peyroux, J; Roques, BP; Schmidt, C | 1 |
| Burks, TF; Lemcke, PK; Shook, JE | 1 |
| Caudle, RM; Chavkin, C; Wagner, JJ | 1 |
| Janak, PH; Martinez, JL | 1 |
| Olley, JE; Scheer, J; Tiong, GK; von Jenner, NM | 1 |
| Barnard, EA; Demoliou-Mason, CD; Hanley, MR; Wong, YH | 1 |
| Gosnell, BA; Majchrzak, MJ | 2 |
| Katki, AG; Schwarz, S | 1 |
| Mulder, AH; Schoffelmeer, AN; van Vliet, BJ | 1 |
| Bose, R; Glavin, GB; Hall, A; Pinsky, C | 1 |
| Feger, J; Maldonado, R; Roques, BP; Waksman, G | 1 |
| Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN | 1 |
| Hohmann, AG; Matsumoto, RR; Thompson, LA; Walker, JM | 1 |
| Henry, JL; Rochford, J | 1 |
| Apte, RN; Durum, SK; Oppenheim, JJ | 1 |
| Hammer, RP | 1 |
| Donich, SG; Fomchenkov, EP; Grebenchikova, OA; Kuznetsov, AIu; Likhvantsev, VV; Makhmutov, RF; Peretrukin, AI; Shloznikov, BM | 1 |
| Klein, P; Nelson, WL; Simon, EJ; Yao, YH | 1 |
| Hill, RG; Hughes, J; Hunter, JC; Rodriguez, RE; Traynor, JR | 1 |
| Goromaru, N; Kanematsu, K; Koike, K; Konno, F; Mori, T; Takayanagi, I; Yoshida, M | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Evans, RG; Ludbrook, J | 1 |
| Landymore, KM; Wilkinson, M | 2 |
| Fuentes, JA; Iglesias, T; Jiménez, I | 1 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Liebmann, C; Neubert, K; Repke, H; Schnittler, M; Schrader, U; Schulze, HP | 1 |
| Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Hahn, EF; Howard, DH; Levison, JA; Pasternak, GW; Paul, D; Pick, CG | 1 |
| Herz, A; Parsons, CG | 1 |
| Fan, LQ; Hiller, JM; Simon, EJ | 1 |
| Delle, M; Hoffmann, P; Thorén, P | 1 |
| Duan, SM; Fukuda, A; Hori, T; Oomura, Y; Shimizu, N | 1 |
| Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Bach, JF; Dardenne, M; Gagnerault, MC; Savino, W | 1 |
| Nishida, N | 1 |
| Cowan, A; Murray, CW | 1 |
| Dygai, AM; Goldberg, ED; Shakhov, VP; Zakharova, O | 1 |
| Jones, SL; Light, AR; Sedivec, MJ | 1 |
| Andreou, A; Angelopoulos, EK; Koutsoukos, E; Loukas, S; Maillis, A; Stefanis, C; Zioudrou, C | 1 |
| Burks, TF; Hruby, VJ; Spencer, RL | 2 |
| Borrell, J; Guaza, C; Sandi, C | 1 |
| Austin, MC; Kalivas, PW | 1 |
| García Antón, JM; Reig, F; Rodríguez, FD; Rodríguez, RE; Sacristán, MP; Torres, JL; Valencia, G | 1 |
| Grässler, J; Kühne, H; Slepuschkin, VD; Steinke, M; Zoloev, GK | 1 |
| Gonzalez, JP; Patel, A; Sewell, RD; Smith, HJ; Williams, PS; Yu, Z | 1 |
| Leek, BF; Maas, CL | 1 |
| Macdonald, RL; Werz, MA | 5 |
| Cherubini, E; Morita, K; North, RA | 1 |
| Dua, AK; LaBella, FS; Pinsky, C | 1 |
| Donnerer, J; Lembeck, F | 1 |
| Goodman, RR; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Hahn, EF; Itzhak, Y; Johnson, N; Nishimura, S; Pasternak, GW | 1 |
| Hansen, HA; Mulder, AH; Schoffelmeer, AN; Stoof, JC | 2 |
| Kehl, LJ | 1 |
| Laurent, S; Marsh, JD; Smith, TW | 2 |
| Berg, DK; Margiotta, JF | 1 |
| Cesselin, F; Hamon, M; Legrand, JC; Lutz, O; Mauborgne, A | 1 |
| Narahashi, T; Tsunoo, A; Yoshii, M | 1 |
| Kaliner, MA; Logun, C; Lundgren, J; Shelhamer, JH | 1 |
| Drozd, IuV; Iasnetsov, VV; Shashkov, VS | 1 |
| Kavaliers, M | 3 |
| Foster, JS; Moore, RN | 1 |
| Larson, DL; Lemieux, C; Nguyen, TM; Portoghese, PS; Ronsisvalle, G; Schiller, PW; Takemori, AE | 1 |
| Das, N; Gupta, VS; Mediratta, PK; Sen, P | 2 |
| Mihara, S; North, RA; Surprenant, A | 1 |
| Bodnar, RJ; Burks, TF; Clark, JE; Hahn, EF; Pasternak, GW; Williams, CL | 1 |
| Chalazonitis, A; Crain, SM; Shen, KF | 1 |
| Tsou, K; Wang, FS | 1 |
| Ball, AK; Weiler, R | 1 |
| Beitner, DB; Duman, RS; Nestler, EJ | 1 |
| Cote, A; Haddad, GG; Rosen, CL | 1 |
| Lorenz, RG; Roth, KA; Unanue, RA; Weaver, CT | 1 |
| Abbott, FV; Kunos, G; Mastrianni, JA | 1 |
| deGroat, WC; Hisamitsu, T; Nagel, J; Roppolo, JR; Thor, KB; Tuttle, P | 1 |
| Herz, A; Millan, MJ; Peter, K; Shippenberg, TS; Stein, C | 1 |
| Alvarado, MC; Bennett, EL; Hruby, VJ; Martinez, JL; Patterson, TA; Rosenzweig, MR; Schulteis, G | 1 |
| Basbaum, AI; Levine, JD; Perry, F; Taiwo, YO | 1 |
| Kwen-Jen, C; Russell, RD | 1 |
| Kobylyansky, AG; Nesterenko, PN; Pivovarov, AS; Yarygin, KN | 1 |
| Kobylyansky, AG | 1 |
| Masuyama, Y; Tsuda, K | 1 |
| Di Chiara, G; Fenu, S; Morelli, M | 1 |
| Buckingham, JC; Cover, PO | 1 |
| Parratt, JR; Sitsapesan, R | 1 |
| Archer, S; Bidlack, JM; Frey, DK; Seyed-Mozaffari, A | 1 |
| Garcia Antón, JM; Rodriguez, FD; Rodriguez, RE; Sacristán, MP; Torres, JL; Valencia, G | 1 |
| Bueno, L; Gué, M; Junien, JL | 1 |
| Kanda, A; Kimura, T; Koyanagawa, H; Musha, T; Satoh, S | 1 |
| Liang, CS; Sakamoto, S | 1 |
| Kiritsy-Roy, JA; Marson, L; Van Loon, GR | 2 |
| Aleksandrovich, AG; Timoshin, SS; Uchakina, RV; Zhdanova, TF | 1 |
| Stevens, CW; Yaksh, TL | 1 |
| Fuchs, BA; Loveless, SE; Munson, AE; Sikorski, EE; Srisuchart, B | 1 |
| Hong, EK; Takemori, AE | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 1 |
| Bodnar, RJ; Gistrak, MA; Pasternak, GW; Paul, D | 1 |
| Dashwood, MR; Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Kaneto, H; Kawasaki, K; Maeda, M; Takahashi, M; Watanabe, J | 1 |
| Crisp, T; Spanos, LJ; Stafinsky, JL | 1 |
| Edwards, AV; Jones, CT | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Kodama, H; Kondo, M; Koshizaka, T; Kurono, M; Matsueda, R; Ogasawara, T; Shimohigashi, Y; Soejima, K; Yagi, K | 1 |
| Hirooka, Y; Mitsuma, T; Nakada, K; Nogimori, T; Nomura, A | 1 |
| Huidobro-Toro, JP; Li, CH; Valenzuela, R | 1 |
| Laniyonu, AA; Ohia, SE | 1 |
| Bals-Kubik, R; Herz, A; Shippenberg, TS | 1 |
| Algeri, S; Botta, G; Cremaschi, D; Meyer, G; Tavani, A | 1 |
| Moyanova, SG; Rousseva, SP | 1 |
| Kumazawa, T; Minagawa, M; Mizumura, K; Sato, J | 1 |
| Gintzler, AR; Smolens, I; Xu, H | 1 |
| Pencheva, N; Radomirov, R; Venkova, K | 1 |
| de Groat, WC; Kawatani, M | 1 |
| Kaliuzhnyĭ, AE; Mironova, OV; Platonov, ES; Sukhikh, GT | 1 |
| Caline, H; Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Jackson, HC; Kitchen, I | 1 |
| Coghlan, JP; Scoggins, BA; Tresham, JJ; Wang, XM | 1 |
| Rodríguez, RE; Sacristán, MP | 1 |
| Fournie-Zaluski, MC; Guilbaud, G; Kayser, V; Roques, BP | 1 |
| Bernardi, G; Calabresi, P; Mercuri, NB; Stanzione, P; Stefani, A | 1 |
| Starke, K; Szabo, B; Wichmann, T | 1 |
| Berzetei, IP; Duckles, SP; Yamamura, HI | 1 |
| Cunningham, FJ; Stansfield, SC | 3 |
| Brown, SR; Cox, BM; Werling, LL | 1 |
| Herblin, WF; Kauer, JC; Tam, SW | 1 |
| Pasternak, GW; Recht, LD | 1 |
| Kennedy, C; Krier, J | 2 |
| Cross, AJ; Hille, C; Slater, P | 1 |
| Artymyshyn, R; Eckenrode, TC; Murray, M | 1 |
| Kunos, G; Mosqueda-Garcia, R | 1 |
| Moak, CM; Murphy, MG; Rao, BG | 1 |
| Donahoe, RM; Falek, A; Madden, JJ; Shafer, DA; Zwemer-Collins, J | 1 |
| Hill, JM; Ostrowski, NL; Pert, A; Pert, CB | 1 |
| Bockaert, J; Eybalin, M; Pujol, R | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Lessor, RA; McLean, S; Rice, KC; Rothman, RB | 1 |
| Childers, SR | 1 |
| La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 2 |
| Dougall, IG; Leff, P | 1 |
| Browne, JL; Pilcher, CW | 1 |
| Bose, R; Frederickson, RC; Pinsky, C | 1 |
| Everitt, BJ; Herbert, J; Hughes, AM | 1 |
| An, L; Liu, DX; Lou, AL; Lü, ZB; Zuo, HM | 1 |
| Rand, MJ; Wong-Dusting, H | 1 |
| Gramsch, C; Herz, A; Kosin, S; Schulz, R | 1 |
| Cox, BM; Puttfarcken, PS; Werling, LL | 1 |
| Bak, TH; Carr, KD | 1 |
| Henke, PG; Ray, A; Sullivan, RM | 1 |
| Mathiasen, JR; Raffa, RB; Vaught, JL | 1 |
| Burks, TF; Heyman, JS; Mosberg, HI; Porreca, F; Williams, CL | 1 |
| Martinez, JL; Schulteis, G; Weinberger, SB | 1 |
| Bolger, GT; Marcus, KA; Skolnick, P; Thibou, R; Weissman, BA | 1 |
| Krumins, SA | 1 |
| Ishizuka, Y; Oka, T | 1 |
| Keldysh, PL; Kurochkin, IN; Skliankina, OA; Varfolomeev, SD; Zaĭtsev, SV | 1 |
| Dreifuss, JJ; Dubois-Dauphin, M; Raggenbass, M; Wuarin, JP | 1 |
| Barnard, EA; Demoliou-Mason, CD; Wong, YH | 1 |
| Hosomi, H; Morita, H; Motochigawa, H; Nishida, Y; Uemura, N; Vatner, SF | 1 |
| Bolger, GT; Rice, KC; Skolnick, P; Weissman, BA | 1 |
| Brinsfield, KH; Matsumoto, RR; Patrick, RL; Walker, JM | 1 |
| Carroll, JA; Shaw, JS; Wickenden, AD | 1 |
| Martynova, EA; Medvedev, OS | 1 |
| Ahmad, S; Allescher, HD; Daniel, EE; Dent, J; Fox, JE; Kostolanska, F | 1 |
| McLaughlin, P; Zagon, IS | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 1 |
| Herz, A; Millan, MJ; Morris, BJ | 1 |
| Doi, T; Fujino, M; Kuzuna, S | 1 |
| Casellas, AM; De Jesus, S; Guardiola, H; Renaud, FL | 1 |
| Bilibin, DP; Shevelev, OA | 1 |
| Janković, BD; Marić, D | 2 |
| Daugé, V; Roques, BP; Rossignol, P | 1 |
| Jeftinija, S | 1 |
| Baudry, M; Gall, C; Shahi, K | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 1 |
| Belcheva, M; Csanady, G; Medzihradszky, K; Szucs, M; Varga, E; Wollemann, M | 1 |
| Dashwood, MR; Muddle, JR; Spyer, KM | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 2 |
| Katoh, M; Kimura, T; Satoh, S | 1 |
| Goldstein, A; Herman, BH | 1 |
| Duckles, SP; Gulya, K; Hruby, VJ; Pelton, JT; Yamamura, HI | 1 |
| Deguchi, T; Yokoyama, E | 1 |
| Grossman, A; Sutton, JR | 1 |
| Dodson, BA; Miller, KW | 1 |
| Baskin, DS; Hosobuchi, Y; Kuroda, H; Lee, NM | 1 |
| Imura, H; Inoue, T; Kabayama, Y; Kato, Y; Matsushita, N; Ohta, H; Shimatsu, A; Tojo, K; Yanaihara, N | 1 |
| Hirst, M | 1 |
| Bitar, KN; Makhlouf, GM | 2 |
| Bicknell, RJ; Chapman, C; Leng, G | 2 |
| Duckles, S; Gulya, K; Hruby, VJ; Pelton, JT; Yamamura, HI | 1 |
| Kalivas, PW; Miller, JS; Taylor, S | 1 |
| Falke, NE; Fischer, EG; Martin, R | 1 |
| Frances, B; Meunier, JC; Moisand, C | 1 |
| Falke, N; Martin, R | 1 |
| Durant, PA; Yaksh, TL | 1 |
| Illes, P; Starke, K; Von Kügelgen, I; Wolf, D | 1 |
| Chang, SW; Voelkel, NF | 1 |
| Barnard, EA; Demoliou-Mason, CD | 1 |
| Bogaert, MG; De Schaepdryver, AF; Lefebvre, RA | 1 |
| Wahl, M | 2 |
| Buder, M; Fuder, H; Riers, HD; Rothacher, G | 1 |
| Brenner, AS; Geppert, M; Illes, P; Jackisch, R | 1 |
| Jensen, TS; Yaksh, TL | 1 |
| Fukuda, H; Nagano, N; Oka, J; Suzuki, T | 1 |
| Pasternak, GW; Wood, PJ | 1 |
| Gulya, K; Hruby, VJ; Pelton, JT; Yamamura, HI | 1 |
| Demura, H; Nakagami, Y; Shizume, K; Suda, T; Sumitomo, T; Tomori, N; Ushiyama, T; Yajima, F | 1 |
| Colpaert, FC; Członkowski, A; Herz, A; Höllt, V; Millan, MH; Millan, MJ; Pilcher, CW | 1 |
| Lefebvre, RA | 1 |
| Cohen, ML; Gesellchen, PD; Osborne, JJ; Shuman, RT | 1 |
| Burks, TF; Deupree, D; Hruby, V; Hsiao, S; Mosberg, HI; Porreca, F; Spencer, RL | 1 |
| Kastin, AJ; Zadina, JE | 1 |
| Akita, K; Hatanaka, H; Maruyama, M; Sugino, H | 1 |
| Ding, XZ; Fan, SG; Han, JS | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Corti, V; Ledda, F; Mantelli, L | 1 |
| Dickenson, AH; Knox, RJ | 1 |
| Russell, NJ; Schaible, HG; Schmidt, RF | 1 |
| Fukuda, H; Oka, J; Suzuki, T | 1 |
| Han, SP; Xie, GX | 1 |
| Castellano, C; Pavone, F | 1 |
| Anticich, TG; Baumeister, AA; Hawkins, MF; Higgins, TD; Moore, LL | 1 |
| Burks, TF; Hruby, VJ; Lemcke, PK; Pelton, JT; Porreca, F; Shook, JE | 1 |
| Cameron, DJ | 1 |
| Dzoljic, MR; Haffmans, J; van Amsterdam, JC; Walsum, MV | 1 |
| Benyhe, S; Borsodi, A; Hepp, J; Khan, A; Medzihradszky, K; Simon, J; Szücs, M; Wollemann, M | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; McWilliam, JR | 2 |
| Iyengar, S; Kim, HS; Wood, PL | 1 |
| Gulya, K; Hruby, VJ; Kazmierski, W; Lui, GK; Pelton, JT; Yamamura, HI | 1 |
| Holaday, JW; Tortella, FC | 2 |
| McLean, S; Rothman, RB | 1 |
| Chavkin, C; Mailheau, S; Neumaier, JF | 1 |
| Banks, WA; Kastin, AJ; Nager, BJ | 1 |
| Arjune, D; Bodnar, RJ; Hahn, EF; Mann, PE; Pasternak, GW; Romero, MT | 1 |
| Grider, JR; Makhlouf, GM; Severi, C | 1 |
| Moon, TD | 1 |
| Chavkin, C; Neumaier, JF; Swearengen, E | 1 |
| Adler, MW; Geller, EB; Tiseo, PJ | 1 |
| Iwamoto, ET | 1 |
| Clark, JA; Houghten, R; Pasternak, GW | 1 |
| Hedler, L; Schurr, C; Starke, K; Szabo, B | 1 |
| Fujiwara, M; Kurahashi, K; Okamoto, T | 1 |
| Douglas, H; Kitchen, I | 1 |
| Johnson, DR; Oleson, DR | 1 |
| Bueno, L; Fioramonti, J; Gué, M; Junien, JL | 1 |
| Edelman, NH; Santiago, TV | 1 |
| Ehrenreich, H; Goebel, FD | 1 |
| Eskay, R; Kunos, G; Mosqueda-Garcia, R; Palkovits, M; Zamir, N | 1 |
| Dias, RD; Izquierdo, I; Netto, CA | 1 |
| Anderson, JH; Merrill, GA | 1 |
| Brown, MR; Lenz, HJ | 1 |
| Timoshin, SS; Zhdanova, TF | 1 |
| Stojanović, V; Varagić, VM | 1 |
| Koenig, JI; Krulich, L; Moss, RL; Wiesner, JB | 1 |
| Di Gleria, K; Medzihradszky, K; Szücs, M | 1 |
| Almirez, RG; Gilbeau, PM; Holaday, JW; Smith, CG | 1 |
| Ling, GS; Lockhart, SH; Pasternak, GW; Spiegel, K | 1 |
| Portoghese, PS; Takemori, AE | 3 |
| Dua, AK; Pinsky, C | 1 |
| Russell, JA; Simons, EJ | 1 |
| Ensinger, HA | 1 |
| Long, JB; Tortella, FC | 1 |
| Ji, XQ; Liu, S; Zhang, HL; Zou, G | 1 |
| Neil, A | 1 |
| Barber, DJ; Barbour-McMullen, J; Cooper, SJ | 1 |
| Bemis, KG; Hymson, DL; Hynes, MD; Lochner, MA | 2 |
| Cohen, AH; Goodman, RR; Inturrisi, CE; Pasternak, GW; Yoburn, BC | 1 |
| Glasel, JA; Myers, WE | 1 |
| Khalangot, ND; Oleĭnik, VA | 1 |
| Cetel, NS; Quigley, ME; Reid, RL; Ropert, JF; Yen, SS | 1 |
| Cariou, G; Conort, P | 1 |
| Genazzani, AR; Panerai, AE; Petraglia, F; Sacerdote, P | 1 |
| Rand, MJ; Wong-Dusting, HK | 1 |
| Holaday, JW; Robles, L; Tortella, FC | 1 |
| Costa, T; Gramsch, C; Herz, A; Wüster, M | 1 |
| Dray, A; Nunan, L; Wire, W | 3 |
| Ades, EW; Culwell, M; Kerchner, GA; Mendelsohn, LG | 1 |
| Chandra, A; Diliberto, EJ; Dixon, WR; Holaday, JW; Lewis, JW; Long, JB; Tortella, FC; Unsworth, CD; Viveros, OH; Way, EL | 1 |
| Pan, HS; Penney, JB; Young, AB | 1 |
| Burke, TR; Danks, JA; Jacobson, AE; Rice, KC; Rothman, RB | 1 |
| Khachaturian, H; Lewis, ME; Watson, SJ | 1 |
| Haddad, GG; Schaeffer, JI | 1 |
| Hájek, I; Syková, E; Teisinger, J | 1 |
| Besvershenko, IA; Khomjakov, JN; Pschenichkin, SP; Shchurin, MR; Zozulya, AA | 1 |
| Bidlack, JM; Denton, RR | 1 |
| Ayres, EA; Burks, TF; Spencer, RL | 1 |
| Burks, TF; Hirning, LD; Peterson, LJ | 1 |
| Flemström, G; Jedstedt, G; Nylander, O | 1 |
| Laubie, M; Schmitt, H | 1 |
| Chavkin, C; Dana, RC; de Graaf, JS; Martinez, JL | 1 |
| Miller, L; Shaw, JS | 1 |
| Gan'shina, TS; Mirzoian, RS; Ragimov, KhS | 1 |
| Richards, ML; Sadée, W; Yu, VC | 1 |
| Hájek, I; Kríz, N; Syková, E | 1 |
| Donoghue, JP; Herkenham, M | 1 |
| Faden, AI | 1 |
| Charness, ME; Diamond, I; Querimit, LA | 1 |
| Kaneto, H; Kawasaki, K; Maeda, M; Tsuji, T; Watanabe, J | 1 |
| Bettermann, R; Illes, P | 1 |
| Gershow, J; Krames, ES; Wilkie, DJ | 1 |
| Gordon, FJ | 1 |
| Belenky, GL; Hitzemann, RJ; Holaday, JW; Long, JB; Tortella, FC | 1 |
| Howlett, TA; Rees, LH | 1 |
| Peterson, NA; Raghupathy, E; Rhoads, DE; Sankaran, H | 1 |
| Blurton, PA; Broadhurst, AM; Wood, MD; Wyllie, MG | 1 |
| Su, TP; Weissman, AD; Yeh, SY | 1 |
| Hosomi, H; Koyama, S | 1 |
| Moss, RL; Wiesner, JB | 1 |
| Enginar, N; Hatipoğlu, I; Koyuncuoğlu, H | 1 |
| Pasternak, GW | 2 |
| Mayer, DJ; Watkins, LR | 1 |
| Cherkovich, GM; Fufacheva, AA; Golanov, EV | 1 |
| Brown, SR; Cote, TE; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Appel, NM; Kiritsy-Roy, JA; van Loon, GR | 1 |
| Fang, FG; Fields, HL; Lee, NM | 1 |
| Goldberg, S; Haertzen, C; Johnson, RE; Kumor, K; Su, TP; Vaupel, B | 1 |
| Rózsa, KS; Solntseva, EJ | 1 |
| Liu-Chen, LY; Tam, SW | 1 |
| Heyman, JS; Koslo, RJ; Mosberg, HI; Porreca, F; Tallarida, RJ | 1 |
| Greenspan, DL; Musacchio, JM | 1 |
| Han, JS; Shi, YS; Xuan, YT; Zhou, ZF | 1 |
| Fan, JZ; Guan, GX; Lin, SX; Wang, ZH; You, SJ | 1 |
| Kimura, H; Mapelli, C; Stammer, CH | 1 |
| Appel, NM; Bobbitt, FG; Kiritsy-Roy, JA; Van Loon, GR | 1 |
| Itzhak, Y; Pasternak, GW | 1 |
| Iversen, SD; Mucha, RF | 1 |
| Benoist, JM; Gacel, G; Gautron, M; Guilbaud, G; Kayser, V; Roques, B; Zajac, JM | 1 |
| James, MK; Leighton, HJ | 1 |
| Chang, KJ; Leslie, JB; Russell, RD; Su, YF; Watkins, WD | 1 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Kotlińska, J; Langwiński, R | 1 |
| Noble, EP; Noble, L; Ritchie, T; Syapin, PJ | 1 |
| Rezvani, A; Rhoads, DL; Stokes, KB; Way, EL | 1 |
| Bloom, FE; Henriksen, SJ; Wiesner, JB | 1 |
| Bailey, CJ; Flatt, PR | 1 |
| Duffy, P; Kalivas, PW; Latimer, LG | 1 |
| Gardner, EL; Vaysse, PJ; Zukin, RS | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 2 |
| Hazato, T; Kawamuki, K; Shimamura, M | 1 |
| Barnes, JC; Briggs, I | 1 |
| Clarke, RW; Ford, TW | 1 |
| Wienbeck, M | 1 |
| Buéno, L; Fioramonti, J | 1 |
| Cruciani, RA; Lutz, RA; Munson, PJ; Rodbard, D | 1 |
| Kasakov, L; Papasova, M; Velkova, V | 1 |
| Bakalkin, GIa; Pivovarov, AS; Romanenko, OK | 1 |
| Aliab'eva, TN; Balashov, AM; Malinovskaia, VV; Panchenko, LF | 1 |
| Iarygin, KN; Korobov, NV; Solov'eva, AI; Spevak, SE; Vinogradov, VA | 1 |
| Barchas, JD; Evans, CJ; Hurlbut, DE; Leslie, FM | 1 |
| Madamba, SG; Moore, SD; Siggins, GR; Zieglgänsberger, W | 1 |
| Grossman, A | 2 |
| Grässler, J; Kühne, H; Scheuch, DW; Slepuschkin, VD; Zoloev, GK | 1 |
| Cavicchini, E; Ferri, S; Murari, G; Romualdi, P; Speroni, E | 1 |
| Atchison, SR; Durant, PA; Yaksh, TL | 1 |
| Haddad, GG; Lasala, PA | 1 |
| Costentin, J; Giros, B; Michael-Titus, A; Preterre, P | 1 |
| Wang, XT; Wu, JL | 1 |
| Giles, TD; Given, MB; Lowe, RF; Sander, GE | 1 |
| Arai, H; Hosoda, K; Itoh, H; Morii, N; Mukoyama, M; Nakao, K; Saito, Y; Shirakami, G; Sugawara, A; Yamada, T | 1 |
| Kavaliers, M; Teskey, GC | 1 |
| Chen, YY; Hu, GY; Zou, G | 1 |
| Bruzzone, ME; Marusic, ET | 1 |
| Dzhumbaev, SU; Egamov, IuS; Polonskiĭ, VM; Vinogradov, VA | 1 |
| Del Rio, J; Fernandez-Tome, MP; Gonzalez, Y | 1 |
| Bortolotto, ZA; Cavalheiro, EA; Ikonomidou-Turski, C; Turski, L; Turski, WA | 1 |
| Michaelson, DM; Wien-Naor, D | 1 |
| Zoloev, GK | 1 |
| Faermark, IF; Shvarts, GIa | 1 |
| Jivegård, L; Svanvik, J | 1 |
| Arai, H; Itoh, H; Morii, N; Mukoyama, M; Nakao, K; Saito, Y; Sakamoto, M; Shiono, S; Sugawara, A; Yamada, T | 2 |
| Corbett, AD; Kosterlitz, HW; McKnight, AT | 1 |
| Iasnetsov, VV | 1 |
| Schwartz, JP | 1 |
| Bozarth, M; Jenck, F; Wise, RA | 1 |
| Bastagli, L; Bernardi, P; Caldarera, CM; Muscari, C; Ventura, C | 1 |
| Bueno, L; Fioramonti, J; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T | 1 |
| Dzoljić, E; Varagić, VM | 1 |
| Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF | 1 |
| Gibbons, LC; Rees, WD; Turnberg, LA | 1 |
| Frank, GB; Sudha, TS | 1 |
| Classen, M; Schmid, R; Schusdziarra, V | 1 |
| Cazalis, M; Dayanithi, G; Nordmann, JJ | 1 |
| Geh, SL; Majewski, H; Nott, MW; Rand, MJ | 1 |
| Haddad, GG; Jeng, HJ; Lai, TL | 1 |
| Haglund, U; Holst, JJ; Lind, T; Olbe, L; Rehfeld, JF; Stenquist, B | 1 |
| Bastagli, L; Bernardi, P; Cavazza, M; Fontana, F; Muscari, C; Ventura, C | 1 |
| Begley, DJ; Davson, H; Lipovac, MN; Rakić, L; Zloković, BV | 1 |
| Culkin, DJ; Nemchausky, BA; Robinson, CJ; Wheeler, JS | 1 |
| Pan'kova, TD; Timoshin, SS; Titov, MI | 1 |
| Innes, DG; Kavaliers, M | 2 |
| Il'inskiĭ, OB; Kalenchuk, VU; Kondrikova, ES; Kozlova, MV; Titov, MI | 1 |
| Bentley, AM; Wallis, M | 1 |
| Chan, YS; Cheung, YM; Hwang, JC; Poon, PW; Wong, CL; Wong, TM | 1 |
| Bouvier, M; Gonella, J; Kirschner, G | 1 |
| Dury, JV; Jadot, G; Mesdjian, E; Tamalet, C; Valli, M | 1 |
| Heinrichs, SC; Martinez, JL | 1 |
| Ewen, M; Gregor, L; Saunders, WS; Thornhill, JA; Wilfong, AA | 1 |
| Chai, SH; Han, JS; Tang, J | 1 |
| Imura, H; Katsuura, G; Nakamura, M; Nakao, K; Yanaihara, N | 1 |
| Bueno, L; Primi, MP | 1 |
| Love, JA; Shu, HD; Szurszewski, JH | 1 |
| Mizutani, M; Nakayama, S; Neya, T; Takaki, M; Yamasato, T | 1 |
| Hart, SL; Slusarczyk, H; Smith, TW | 2 |
| Artal, R; Joffe, S; Sperling, MA; Werther, GA | 1 |
| Finkelstein, JA; Go, VW; Micevych, PE; Yaksh, TL | 1 |
| Havemann, U; Kuschinsky, K | 1 |
| Flórez, J; Hurlé, MA; Mediavilla, A | 1 |
| Law, PY; Loh, HH; Louie, AK | 1 |
| Giles, TD; Given, MB; Sander, GE | 1 |
| Amano, T; Fukuuchi, Y; Gogolak, I; Gotoh, F; Kobari, M; Obara, K; Sándor, P; Suzuki, N; Uematsu, D | 1 |
| Barrett, RJ; Kau, ST; McGuirk, BA; Turpin, JA | 1 |
| Agmo, A; de Avila, N | 1 |
| Iwama, T; Satoh, M; Takagi, H; Wada, T | 1 |
| Asdourian, D; Geula, C | 1 |
| Sarne, Y; Segev, S; Urca, G | 1 |
| Csillag, A; Hajós, F | 1 |
| Fujii, N; Kuno, S; Lee, W; Matsushita, M; Sakurai, M; Satoh, M; Takagi, H; Wang, ZM; Yajima, H; Yamamoto, N | 1 |
| Sun, XY; Yao, T | 1 |
| Kitchen, I; Rowan, KM | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Zajac, JM | 1 |
| Itzhak, Y; Simon, EJ | 1 |
| Bakalkin, GIa; Bespalova, ZhD; Iakovleva, TV; Korobov, KP; Vinogradov, VA | 1 |
| Pert, CB; Rothman, RB; Schumacher, UK | 1 |
| Benyhe, S; Borsodi, A; Simon, J; Szücs, M; Wollemann, M; Zeman, P | 1 |
| Hirobe, M; Konno, F; Shibata, R; Takayanagi, I | 1 |
| Brückner, UB; Ganten, D; Lang, RE | 1 |
| Kurochkin, IN; Sergeeva, MG; Varfolomeev, SD; Zaĭtsev, SV | 1 |
| Barg, J; Levy, R; Simantov, R | 1 |
| Bernardini, GL; Clark, WG; Pang, IH | 1 |
| Dray, A; Metsch, R | 1 |
| Cabib, S; Mele, A; Puglisi-Allegra, S | 1 |
| Benton, D; Brain, PF; Brain, S; Jones, SE | 1 |
| Iasnetsov, VV; Motin, VG; Pravdivtsev, VA | 1 |
| Antkiewicz-Michaluk, L; Rokosz-Pelc, A; Vetulani, J | 1 |
| Chernysheva, ON; Kachalov, IuP; Nozdrachev, AD | 1 |
| Bernier, JL; Carette, B; Hénichart, JP | 1 |
| Dray, A; Nunan, L | 1 |
| Abou-Khalil, B; Penney, JB; Young, AB | 1 |
| Chang, KJ; Haddad, GG; Schaeffer, JI | 1 |
| Beleslin, DB; Mićić, D; Samardzić, R; Terzić, B | 1 |
| Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 1 |
| Aoki, K; Inoue, H; Kajiwara, M; Oka, T; Shinozaki, K; Ueki, M | 1 |
| Illes, P; Starke, K; Weitzell, R | 1 |
| Airaksinen, MM; Gynther, J; Huhtikangas, A; Juvonen, H; Saano, V; Steidel, E | 1 |
| Schulz, R; Wüster, M | 1 |
| Carroll, JA; Downes, CP; Miller, L; Shaw, JS | 1 |
| Corbett, AD; Kosterlitz, HW; Marcoli, M; McKnight, AT | 1 |
| Murphy, MG; Rao, BG | 1 |
| Griffin, MT; Law, PY; Loh, HH | 1 |
| Costa, T; Wüster, M | 1 |
| Browne, RG; Segal, DS | 1 |
| Golembiowska-Nikitin, K; Pilc, A; Vetulani, J | 1 |
| Herz, A; Osborne, H | 1 |
| Hiripi, L; Rózsa, KS; Stefano, GB | 1 |
| Elliott, J; Jhamandas, K | 1 |
| Kitabgi, P; Monier, S | 1 |
| Kageyama, T; Kiso, Y; Matsumoto, K; Moritoki, H | 1 |
| Berzas, MC; Coy, DH; Ibanez, ML; Kastin, AJ; King, BM; Olson, GA; Olson, RD; Von Almen, TK | 1 |
| Pert, A | 1 |
| Coy, DH; Kastin, AJ; Luciano, MG; Zadina, JE | 1 |
| Hollander, CS; Moldow, RL | 1 |
| Chavkin, C; Goldstein, A; James, IF | 1 |
| Groves, PM; Ling, N; Nakamura, S; Tepper, JM; Young, SJ | 1 |
| Berger, T; Bloom, FE; French, ED; Shier, T; Siggins, GR | 1 |
| Fujino, M; Imura, H; Katakami, H; Kato, Y; Matsuo, H; Matsushita, N; Shimatsu, A | 1 |
| Tung, AS; Yaksh, TL | 1 |
| Huidobro-Toro, JP; Way, EL; Yoshimura, K | 1 |
| Beleslin, DB; Terzić, B | 1 |
| Bloom, FE; Chouvet, G; Henriksen, SJ; McGinty, J | 1 |
| Takemori, AE; Ward, SJ | 1 |
| Giles, TD; Kastin, AJ; Sander, GE | 1 |
| Brien, J; Jhamandas, K; Marien, M | 1 |
| Green, IC; Perrin, D; Ray, K | 1 |
| Ikeda, Y; Imura, H; Nakao, K; Numa, S; Sakamoto, M; Suda, M; Yanaihara, N; Yoshimasa, T | 1 |
| Garzón, J; Jen, MF; Lee, NM | 1 |
| Chavkin, C; Cox, BM | 1 |
| Hermansen, K | 1 |
| Brown, JC; Kwok, YN; McIntosh, CH; Mordhorst, T; Nishimura, E; Pederson, RA | 1 |
| de la Fuente, A; Holland, A; Pfeiffer, EF; Schick, R; Schusdziarra, V; Specht, J | 1 |
| Kiang, JG; Wei, ET | 1 |
| Lypka, A; Szczudlik, A | 1 |
| Fischli, W; Goldstein, A; James, IF | 1 |
| Chavkin, C; Gruol, DL; Siggins, GR; Valentino, RJ | 1 |
| Champagnat, J; Denavit-Saubie, M; Gacel, G; Morin-Surun, MP; Roques, BP | 1 |
| Hagan, RM; Hughes, IE | 1 |
| Herz, A; Schulz, R; Wüster, M | 2 |
| Bakharev, VD; Tikhomirov, SM | 1 |
| Franklin, PH; Hoss, W | 1 |
| Pairet, M; Ruckebusch, Y | 1 |
| Rezvani, A; Way, EL | 1 |
| Ikeda, Y; Imura, H; Morii, N; Nakao, K; Numa, S; Sakamoto, M; Suda, M; Yanaihara, C; Yanaihara, N; Yoshimasa, T | 1 |
| Jackson, HC; Sewell, RD | 1 |
| Brunello, N; Cagiano, R; Cuomo, V; Racagni, G; Volterra, A | 1 |
| Gramsch, C; Herz, A; Höllt, V; Maysinger, D; Seizinger, BR; Tilders, F; Vermes, I | 1 |
| Livingston, A; Morris, B | 1 |
| Murakoshi, T; Otsuka, M; Tamai, S; Yanagisawa, M | 1 |
| Akil, H; Khachaturian, H; Lewis, ME; Watson, SJ | 1 |
| Yaksh, TL | 1 |
| Sun, FY; Yu, GH; Zhang, AZ; Zhang, LM | 1 |
| Ercan, ZS; Ilhan, M; Türker, RK | 1 |
| Zieglgänsberger, W | 1 |
| Davies, J; Dray, A | 1 |
| Herkenham, M; Pert, CB | 2 |
| McQueen, DS; Ribeiro, JA | 2 |
| del Río, J; Garzón, J; Naranjo, JR; Sánchez-Franco, F | 1 |
| Giles, T; Merz, H; Sander, G | 1 |
| Go, VL; Micevych, PE; Yaksh, TL | 1 |
| Chung, JM; Hori, Y; Lee, KH; Willcockson, WS; Willis, WD | 1 |
| Dun, NJ; Jiang, ZG; Simmons, MA | 1 |
| Allen, J; Kay, N; Morley, JE | 1 |
| Furuta, H; Sugiyama, K | 1 |
| De Graef, J; Kostritsky-Pereira, A; Woussen-Colle, MC | 1 |
| Wen, XL | 1 |
| Cieszkowski, M; Coy, DH; Konturek, SJ; Mikoś, E; Schally, AV; Tasler, J | 1 |
| Kream, RM; Stefano, GB; Zukin, RS | 1 |
| Costa, E; Guidotti, A; Karoum, F; Kumakura, K | 1 |
| Segal, M; Simantov, R; Zamir, N | 1 |
| Makman, MH; Walczak, S; Zukin, RS | 1 |
| Ofuji, T; Ogawa, N; Yamawaki, Y | 1 |
| Simon, EJ; Smith, JR | 1 |
| Adler, MW | 1 |
| Ng, SC; Tsang, D | 1 |
| Bourgoin, S; Cesselin, F; Gros, C; Hamon, M; Montastruc, JL | 1 |
| Gähwiler, BH | 1 |
| Meites, J; Van Vugt, DA | 1 |
| Clemens, JA; Shaar, CJ | 1 |
| Chang, KJ; Cuatrecasas, P; Hazum, E | 2 |
| Chavkin, C; Cox, BM; Leslie, FM | 1 |
| Herkenham, MA; Kent, JL; Pert, A; Pert, CB; Taylor, DP | 1 |
| Herz, A; Illes, P; Zieglgänsberger, W | 1 |
| Dreifuss, JJ; Gaehwiler, BH; Muehlethaler, M | 1 |
| Imura, H; Ling, N; Nakai, Y; Nakao, K; Oki, S | 1 |
| Binder, HJ; Dobbins, J; Racusen, L | 1 |
| Baptiste, EJ; Rizack, MA | 1 |
| Bakalkin, GIa; Iarygin, KN; Smirnov, VN; Titov, MI; Trushina, ED | 1 |
| Chariot, J; Dubrasquet, M; Rozé, C; Vaille, C | 1 |
| Hiripi, L; Stefano, GB; Vadasz, I | 1 |
| Balasubramanian, TM; Cicero, TJ; Gorin, FA; Marshall, GR; Schwietzer, J | 1 |
| Fondacaro, JD; Pawlik, WW; Walus, KM | 1 |
| Brownell, J; del Pozo, E; Donatsch, P | 1 |
| Bloom, FE; Hatton, JD; Pittman, QJ | 1 |
| Kosterlitz, HW | 1 |
| Anokhina, IP; Balashov, AM; Morozov, GV; Panchenko, LF; Vekshina, NL | 1 |
| Linaker, BD; McKay, JS; Turnberg, LA | 1 |
| Groth, J; Hiller, JM; Howells, RD; Simon, EJ | 1 |
| Davila, K; Jensen, RA; Lynch, GS; McGaugh, JL; Oliver, MW | 1 |
| Bragin, E; Brown, RM; Lewis, ME; Mishkin, M; Pert, A; Pert, CB | 1 |
| Audigier, Y; Cros, J; Mazarguil, H; Rossier, J | 1 |
| Chang, JK; Chang, KJ; Cuatrecasas, P; Hazum, E; Lillian, A | 1 |
| Besson, JM; Kraus, E; Le Bars, D | 1 |
| Gramsch, C; Herz, A; Höllt, V; Jerlicz, M; Millan, MJ; Przewłocki, R | 1 |
| Williams, J; Zieglgänsberger, W | 1 |
| Larsson, LI; Stengaard-Pedersen, K | 1 |
| Huidobro, F; Huidobro-Toro, JP | 1 |
| Kitano, T; Takemori, AE; Vaught, JL | 1 |
| Handa, BK; Land, AC; Lord, JA; Morgan, BA; Rance, MJ; Smith, CF | 1 |
| Dal Bello, A; Drago, F; Gorgone, G; Moro, F; Panissidi, G; Scapagnini, U; Spina, F | 1 |
| Dvorkin, B; Hall, B; Makman, MH; Stefano, GB | 1 |
| Carrasco, MA; Dias, RD; Elisabetsky, E; Izquierdo, I; Perry, ML; Souza, DO | 1 |
| Bhargava, KP; Dixit, KS; Gupta, YK | 1 |
| Byrne, WL; Codd, EE | 1 |
| Chang, JK; Pasternak, GW; Zhang, AZ | 1 |
| Chang, KJ; Cuatrecasas, P; Hazum, E; Pasternak, GW | 1 |
| Coghlan, JP; Tregear, GW | 1 |
| Kosterlitz, HW; Paterson, SJ; Robson, LE | 1 |
| Buatti, MC; Pasternak, GW | 1 |
| Rothman, RB; Westfall, TC | 4 |
| Do, KQ; Fauchère, JL; Lemieux, C; Schiller, PW; Schwyzer, R | 1 |
| Coscia, CJ; Laskowski, MB; Roth, BL | 1 |
| Banay-Schwartz, M; Lajtha, A; Manigault, I; Wajda, IJ | 1 |
| Keil, LC; Rosella, LM; Summy-Long, JY | 1 |
| Bonnet, KA; Cortes, M; Gioannini, T; Groth, J; Simon, EJ | 1 |
| Dokas, LA; Kong, A; Lymangrover, JR; Martin, R; Saffran, M | 1 |
| Glaser, T; Hamprecht, B; Hübner, K | 2 |
| Bons, EG; Lamberts, SW; Oosterom, R; Uitterlinden, P; Verleun, T | 1 |
| Adler, MW; Cowan, A; Tortella, FC | 3 |
| Chang, KJ; Cuatrecasas, P; Hazum, E; Killian, A | 1 |
| Blume, AJ; Fantozzi, R; Mullikin-Kilpatrick, D | 1 |
| Konishi, S; Otsuka, M; Tsunoo, A | 1 |
| Appel, NM; Van Loon, GR | 1 |
| Williams, JT; Zieglgänsberger, W | 1 |
| Lajtha, A; Reith, ME; Sershen, H; Vadasz, C | 1 |
| Pasternak, GW; Zhang, AZ | 1 |
| Siggins, GR; Zieglgänsberger, W | 1 |
| Dekker, I; Martinez, JL; Rigter, H | 1 |
| Herkenham, M; Kent, JL; Pert, CB | 1 |
| Besser, GM; Gaillard, RC; Grossman, A; Rees, LH; Smith, R | 1 |
| Pasternak, GW; Wolozin, BL | 1 |
| Cupello, A; Hydén, H | 1 |
| Cowan, A; Tortella, FC | 1 |
| Kuroda, H; Nukina, I; Ofuji, T; Ogawa, N; Yamawaki, Y | 1 |
| Bernardini, GL; Clark, WG | 1 |
| Ishii, T | 1 |
| Borsi, L; Delitala, G; Devilla, L; Giordano, G; Giusti, M; Lotti, G; Mazzochi, G | 1 |
| Gilbert, JA; Knodel, EL; Richelson, E; Stenstrom, SD | 1 |
| Fellion, E; Fournié-Zaluski, MC; Gacel, G; Roques, BP | 1 |
| Corrigall, WA; Linseman, MA | 1 |
| Chang, JK; Jen, MF; Lee, NM; Loh, HH; Tulunay, FC | 1 |
| Cooper, DM; Gill, DL; Londos, C; Rodbell, M | 1 |
| Blanchard, SG; Chang, KJ; Eckel, RW | 1 |
| Hiroto, S; Imura, H; Katakami, H; Kato, Y; Matsushita, N; Shimatsu, A | 1 |
| Carette, B; Poulain, P | 1 |
| Babichev, VN; Ignatkov, VIa; Mironov, SF; Shvachkin, IuP; Smirnova, AP | 1 |
| Gottschaldt, KM; Vahle-Hinz, C | 1 |
| DiMaio, J; Schiller, PW | 1 |
| Herz, A; Shearman, GT | 1 |
| Ho, KP; Ng, SC; Tsang, D | 1 |
| Coscia, CJ; Roth, BL; Wohltmann, M | 1 |
| Allolio, B; Hipp, FX; Kaulen, D; Mies, R; Winkelmann, W | 1 |
| Dixon, WR; Gaddis, RR | 1 |
| Chang, JK; Chang, KJ; Cuatrecasas, P; Wei, ET | 1 |
| Huang, YH; Redmond, DE | 1 |
| Snyder, SH | 2 |
| Nishimura, S; Pasternak, GW; Wolozin, BL | 1 |
| Gayton, RJ | 1 |
| Baker, RJ; McCallum, JA; Sullivan, SN; Wells, G; Worobetz, LJ | 1 |
| Grace, M; Kneip, J; Levine, AS; Morley, JE; Murray, SS | 1 |
| Cox, BM; Ho, WK | 1 |
| Ishizuka, Y; Kajiwara, M; Matsumiya, T; Negishi, K; Oka, T; Watanabe, Y | 1 |
| Chesselet, MF; Glowinski, J; Lubetzki, C | 1 |
| Huhman, M | 1 |
| Hatanaka, H; Inoue, N | 1 |
| Herz, A; Pfeiffer, A | 1 |
| Blalock, JE; Johnson, HM; Smith, EM; Torres, BA | 1 |
| Bloom, FE; Feldman, JD; Gilman, SC; Milner, RJ; Schwartz, JM | 1 |
| Bernardini, GL; Clark, WG; Ponder, SW | 1 |
| Kachur, JF; Miller, RJ | 1 |
| Itzhak, Y; Keren, O; Sarne, Y | 1 |
| Candeletti, S; Cocchi, D; Ferri, S; Giagnoni, G; Rossi, T; Scoto, G; Spampinato, S | 1 |
| Fitz-Syage, ML; Gardner, EL; Gintzler, AR; Sugarman, JR; Zukin, RS; Zukin, SR | 1 |
| Nishimura, S; Pasternak, GW | 1 |
| Gallagher, M; Kapp, BS; Pascoe, JP | 1 |
| Dünzen, RG; Wienbeck, M | 1 |
| Bhanot, R; Wilkinson, M | 1 |
| Costa, T; Krumins, SA; Munson, PJ; Rodbard, D; Shimohigashi, Y | 1 |
| Bearden, LJ; Snead, OC | 1 |
| Faden, AI; Feuerstein, G; Hassen, AH; Pfeiffer, A | 1 |
| Ho, KP; Ho, WK; Ng, SC; Tsang, D | 1 |
| de Jong, W; Petty, MA; Sitsen, JM | 1 |
| Giles, TD; Sander, GE | 1 |
| DiMaio, J; Lemieux, C; Nguyen, TM; Schiller, PW | 1 |
| Simon, EJ | 1 |
| Asmuko, AA; Bespalova, JD; Chetverina, EV; Chichenkov, ON; Korobov, NV; Mestechkina, NM; Miheeva, LM; Rjazhsky, GG; Rogozhin, SV; Zaslavsky, BY | 1 |
| Grossman, A; Rees, LH | 1 |
| Kvaltínová, Z; Machová, J | 1 |
| Flórez, J; Pazos, A | 1 |
| Kamikawa, Y; Shimo, Y | 1 |
| Kandasamy, SB; Williams, BA | 1 |
| Costa, T; Krumins, S; Rodbard, D; Shimohigashi, Y | 1 |
| Holaday, JW | 1 |
| Egawa, M; Imura, H; Katsumaru, Y; Mochizuki, T; Numa, S; Tobe, A; Yamamoto, Y; Yanaihara, C; Yanaihara, N | 1 |
| Garzón, J; Lee, NM; Sánchez-Blázquez, P | 1 |
| Johnson, N; Pasternak, GW | 1 |
| Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 1 |
| Booth, AM; de Groat, WC; Nagel, JR; Ostrowski, NL; Simonds, WF; Thor, KB | 1 |
| Burks, TF; Porreca, F | 1 |
| Tam, SW | 1 |
| Kurochkin, IN; Molokoedov, AS; Sergeeva, MG; Titov, MI; Zaĭtsev, SV | 1 |
| Boublik, JH; Clements, JA; Funder, JW; Herington, AC | 1 |
| Kromer, W; Netz, S; Skowronek, B; Stark, H | 1 |
| Keys, C; Loew, GH; Toll, L | 1 |
| Ikeda, Y; Imura, H; Nakao, K; Numa, S; Sakamoto, M; Suda, M; Yanaihara, C; Yanaihara, N; Yoshimasa, T | 1 |
| Keys, C; Loew, G; Toll, L | 1 |
| Belenky, GL; Gelinas-Sorell, D; Holaday, JW; Kenner, JR | 1 |
| D'Amato, RJ; Holaday, JW | 1 |
| Benton, D; Brain, PF; Brain, S; Dalrymple-Alford, JC; McAllister, KH | 1 |
| Gioannini, TL; Hiller, JM; Itzhak, Y; Simon, EJ | 1 |
| Cowan, A; Holaday, JW; Robles, LE; Tortella, FC | 1 |
| Koskinen, V; Laakso, K; Lönnberg, P; Rinne, JK; Rinne, JO; Rinne, UK; Tenovuo, O | 1 |
| Cotton, R; Giles, MG; Miller, L; Shaw, JS; Timms, D | 1 |
| Akil, H; Khachaturian, H; Lewis, ME; Walker, JM; Watson, SJ; Young, E | 1 |
| Krystal, JH; Redmond, DE | 1 |
| Benton, D; Brain, PF; Brain, S | 1 |
| Bloom, FE | 1 |
| Bock, E; Grynne, BH; Holmen, AT; Slange, K | 1 |
| Fogel, R; Kaplan, RB | 1 |
| Buckingham, JC; Cooper, TA | 1 |
| Faden, AI; Feuerstein, G; Hassen, AH | 1 |
| Duggan, AW; Zhao, ZQ | 1 |
| Fujioka, T; Hayashi, Y; Kanaoka, Y; Kangawa, K; Matsunaga, T; Matsuo, H; Nakayama, H | 1 |
| Koenig, JI; Krulich, L; Mayfield, MA; McCann, SM | 1 |
| Snead, OC; Stephens, H | 1 |
| Costa, T; Cruciani, RA; Lutz, RA; Munson, PJ; Rodbard, D | 1 |
| Brantl, V; de la Fuente, A; Klier, M; Pfeiffer, EF; Schick, A; Schusdziarra, V; Specht, J | 1 |
| Cooper, SJ | 2 |
| Bloom, FE; Koob, GF | 1 |
| Gianoulakis, C | 1 |
| Carratu, MR; Mitolo-Chieppa, D | 1 |
| Awoke, S; Bhathena, SJ; Recant, L; Voyles, N; Wade, A | 1 |
| Petty, MA; Reid, JL; Rubin, PC | 1 |
| Goldstein, A; Han, JS; Xie, GX | 1 |
| Coy, DH; Dobrzańska, M; Gawronek, J; Konturek, SJ; Kwiecień, N; Oleksy, J | 1 |
| Hirst, M; Tepperman, FS | 1 |
| Gambino, MC; Petrillo, P; Tavani, A | 1 |
| Almenoff, J; Glick, SD; Murthy, LR; Orlowski, M; Wilk, S | 1 |
| Kromer, W; Netz, S; Schröder, P | 1 |
| Connor, JD; Drust, EG | 1 |
| Bielański, W; Coy, DH; Konturek, SJ; Kwiecień, N; Obtułowicz, W; Oleksy, J; Swierczek, J | 1 |
| Astier, H; Tapia-Arancibia, L | 1 |
| Mora, F; Shaw, SG; Vives, F | 1 |
| Bo, P; Maurelli, M; Nappi, G; Savoldi, F | 1 |
| Lishmanov, IuB; Prum, IA; Slepushkin, VD | 1 |
| Dlabac, A; Felt, V; Kasafírek, E; Nedvídková, J | 1 |
| Kobayashi, H; Okawara, Y; Tsukahara, T; Uemura, H; Yanaihara, N | 1 |
| Herman, ZS; Kowalski, J; Przewłocki, R; Trzeciak, H | 1 |
| Chung, YH; Kamei, C; Miyake, H; Tasaka, K | 1 |
| Eiden, LE; Ruth, JA | 1 |
| Elhilali, MM; Galeano, C; Jubelin, B; Ladouceur, D; Lemaire, S | 1 |
| Shi, QY; Zhu, LX | 1 |
| Chorev, M; Karmeli, F; Rachmilewitz, D; Selinger, Z | 1 |
| Chaillet, P; Costentin, J; Lecomte, JM; Marçais, H; Natan, LB; Uchida, G | 1 |
| de Groat, WC; Hisamitsu, T | 1 |
| Llorens-Cortes, C; Schwartz, JC | 1 |
| Gataullin, RR | 1 |
| Balderrama, N; Maldonado, H; Miralto, A; Núñez, J | 1 |
| Milanés, MV; Puig, MM; Vargas, ML | 1 |
| Cuizon, JV; Eiden, LE; Ruth, JA | 1 |
| Faden, AI; Jacobs, TP; Zivin, JA | 1 |
| Puig, MM; Vargas, ML | 1 |
| Doi, T; Fujino, M; Ishii, H; Kawai, K; Kuzuna, S; Okanishi, S; Tamura, S | 1 |
| Chaillet, P; Costentin, J; Marçais-Collado, H | 1 |
| Go, VL; Micevychi, PE; Yaksh, TL | 1 |
| Bowdy, BD; Crooks, PA; Gillespie, MN; Iwamoto, ET; Reinsel, CN | 1 |
| Hilston, C; Martinez, JL; Olson, K | 1 |
| Barnett, A; Berger, J; Billard, W; Chipkin, RE; Iorio, LC | 1 |
| Dingledine, R; Valentino, RJ | 1 |
| Alumets, J; Håkanson, R; Sundler, F; Uddman, R; Walles, B | 1 |
| Chen, HT; Meites, J; Sylvester, PW | 1 |
| Gascoigne, AD; Hirst, BH; Reed, JD; Shaw, B | 1 |
| Dzoljic, MR; van der Poel-Heisterkamp, AL | 1 |
| Bjørndal, N; Casey, DE; Gerlach, J | 1 |
| Halász, B; Köves, K; Marton, J; Molnár, J | 1 |
| Besser, GM; Delitala, G; Gaillard, RC; Grossman, A; Moult, PJ; Rees, LH; Toff, WD | 1 |
| Allerton, HW; Isom, GE; Zobrist, RH | 1 |
| Ashcroft, SJ; Pierluissi, J; Pierluissi, R | 1 |
| Katz, RJ; Schmaltz, K | 1 |
| McCarthy, PS; Sanger, DJ | 1 |
| Lahiri, S; Pokorski, M | 1 |
| Emson, PC; Farman, JV; Symons, IE | 1 |
| Delitala, G; Devilla, L; Giordano, G; Giusti, M; Lotti, G; Mazzocchi, G | 1 |
| Anderson, W; Hirschowitz, BI; Molina, E; Rentz, J | 1 |
| Bellet, M; Elghozi, JL; Meyer, P | 1 |
| Belsheim, MR; Howard, JM; Sullivan, SN | 1 |
| Chapman, DB; Way, EL | 1 |
| Dubocovich, ML; Weiner, N | 1 |
| Essawi, MY; Portoghese, PS | 1 |
| Jhamandas, K; Sutak, M | 2 |
| Amosova, AV; Bezrukova, LV; Solntseva, EI | 1 |
| Ewart, WR; Wingate, DL | 1 |
| Dewey, WL; Kiang, JG; Wei, ET | 1 |
| Hedge, GA; Judd, AM | 1 |
| Adams, N; Arnold, J; Dubois, A; Shea-Donohue, PT | 1 |
| Ackermann, RF; Caldecott-Hazard, S; Engel, J; Frederickson, RC; Liebeskind, JC; Shavit, Y | 1 |
| Inturrisi, CE; Lewis, RV; Stein, S; Stern, AS; Udenfriend, S; Umans, JG; Wolff, D | 1 |
| Abram, SE; Cusick, JF; Reynolds, AC | 1 |
| del Río, J; Garzón, J; Rubio, J | 1 |
| Ahlman, H; Dahlström, A; Edin, R; Hökfelt, T; Kewenter, J; Lundberg, J; Terenius, L | 1 |
| Ensinck, JW; Fujimoto, WY; Kanter, RA | 1 |
| Pauser, G | 2 |
| Besser, GM; Delitala, G; Gaillard, RC; Grossman, A; Rees, LH; Stubbs, WA | 1 |
| Brady, LS; Holtzman, SG | 1 |
| Bloom, FE; Iversen, SD; Joyce, EM; Koob, GF; Strecker, R | 1 |
| Dingledine, R | 1 |
| Chiang, Y; Chien, NK; Jenq, LS; Wang, WK | 1 |
| Christiansen, J; Kirkegaard, P; Olsen, PS; Petersen, B | 1 |
| Brückner, UB; Ganten, D; Kempf, B; Lang, RE; Rascher, W; Speck, G; Sturm, V; Unger, T | 1 |
| Coy, D; Giles, T; Kaneish, A; Kastin, A; Sander, G | 1 |
| Edstrom, J; Lukowiak, K; Thornhill, JA | 1 |
| Albert, D; Jaffe, BM; Materia, A; Modlin, IM; Sank, A | 1 |
| LePiane, FG; Phillips, AG | 1 |
| Beani, L; Bianchi, C; Siniscalchi, A | 1 |
| Brückner, UB; Ganten, D; Hermann, K; Kempf, B; Lang, RE; Rascher, W; Sturm, V; Unger, T | 1 |
| Kawamuki, K; Satoh, M; Takagi, H; Yamamoto, M | 1 |
| Dowling, DA; Moore, RH | 2 |
| Belluzzi, JD; Kelsey, JE | 1 |
| Medvedev, OS | 1 |
| Grunstein, JS; Grunstein, MM | 1 |
| Wei, ET | 1 |
| Dias, RD; Izquierdo, I | 1 |
| Hui, KS; Lajtha, A; Tsai, H; Wang, YJ; Wong, KH | 1 |
| Luján, M; Rodríguez, R | 1 |
| Frederickson, RC; Wesche, DL | 1 |
| Flack, HG; Huston, JP; Welzl, H | 1 |
| Schmierer, G; Stacher, G; Steinringer, H | 1 |
| Huston, JP; Oitzl, MS; Ornstein, K; Sprick, U | 1 |
| Clark, SJ; Smith, TW | 1 |
| Deen, K; Keil, LC; Severs, WB; Summy-Long, JY | 1 |
| Chéramy, A; Chesselet, MF; Glowinski, J; Reisine, TD | 1 |
| Bentley, GA; Newton, SH; Starr, J | 1 |
| Koehler, JE; Law, PY; Loh, HH; Wu, J | 1 |
| Bergman, B; Hedner, J; Hedner, T; Lundberg, D | 1 |
| Baile, CA; Della-Fera, MA; Keim, DA; McLaughlin, CL | 1 |
| Imura, H; Katakami, H; Kato, Y; Matsushita, N; Shimatsu, A | 1 |
| Chazov, EI; Smirnov, VN; Titov, MI; Trushina, ED; Yarigin, KN | 1 |
| Nencini, P; Paroli, E | 1 |
| Goldenberg, E; Jhamandas, K; Nakatsu, K; Penning, D | 1 |
| de Jonge, FH; Lopes da Silva, FH; Mollevanger, WJ; Tielen, AM | 1 |
| Castellano, C | 1 |
| Bulgakov, SA; Lebedev, NN; Smagin, VG; Tepliuk, SG; Vinogradov, VA | 1 |
| Dewey, WL; Fu, TC | 1 |
| Frösch, D; Kiehling, C; Martin, R; Schiebe, M; Voigt, KH | 1 |
| Khan, MF | 1 |
| Jacob, J | 1 |
| Dawson, G; McLawhon, R; Miller, RJ | 1 |
| Dunwiddie, T; Hoffer, B; Mueller, A; Palmer, M; Stewart, J | 1 |
| Bellamy, D; Leslie, RD; Pyke, DA | 1 |
| Hedley-Whyte, J; Johnson, EE; Laasberg, LH | 1 |
| Chey, WY; Coy, DH; Konturek, SJ; Schally, AV; Tasler, J | 1 |
| Hannan, TJ; Jensen, RA; Martinez, JL; McGaugh, JL; Messing, RB; Rigter, H; Vasquez, BJ; Veliquette, J | 1 |
| Labella, FS; Pinsky, C; Sawynok, J | 1 |
| Olds, ME; Williams, KN | 1 |
| Celis, ME | 1 |
| Ku, PY; Lee, HK; Yen, MH | 1 |
| Barden, N; Cusan, L; Dupont, A; Labrie, F; Mérand, Y; Vaudry, H | 1 |
| Henderson, G; Pepper, CM | 1 |
| Fukushima, M; Furui, T; Haga, T; Ichiyama, A; Kageyama, N | 1 |
| Chang, JK; Lee, A; Wei, ET | 1 |
| Agnoli, A; D'Urso, R; Del Roscio, S; Falaschi, P; Frajese, G; Mearelli, S; Ruggieri, S | 1 |
| Bär, PR; Gispen, WH; Schotman, P | 1 |
| Eshel, Y; Keren, O; Korczyn, AD | 1 |
| Forman, LJ; Meites, J; Sonntag, WE; Steger, RW; Van Vugt, DA | 1 |
| Blegvad, K; Brandt, NJ; Brandt, S; Jacobsen, BB; Klinken, L; Nordius, A; Terenius, L; Yssing, M | 1 |
| Arancibia, S; Bluet-Pajot, MT; Enjalbert, A; Kordon, C; Priam, M; Rotsztejn, WH; Ruberg, M | 1 |
| Brennan, MJ; Cantrill, RC; Wylie, BA | 1 |
| Forsling, ML; Langdon, N; Lightman, SL | 1 |
| Betti, R; Casanueva, F; Cocchi, D; Müller, EE; Vellani, D | 1 |
| Coy, DH; Dunlap, WP; Harston, CT; Spirtes, MA | 1 |
| Crofton, JT; Rockhold, RW; Share, L | 1 |
| Keresztes-Nagy, P; Rosenfeld, PJ | 1 |
| Ji, XQ; Lu, YX; Wang, FS; Wu, SX; Yi, QC; Yu, YG; Zhang, ZX; Zhao, DD; Zou, G | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Laorden, ML; Llobell, F | 1 |
| Gulya, K; Kása, P; Szikra, J | 1 |
| Bottà, G; Cremaschi, D; Fedele, G; Meyer, G | 1 |
| Childers, SR; Dworkin, SI; Kluttz, BW; Vrana, KE | 1 |
| Chikai, T; Saeki, K | 1 |
| Gibert-Rahola, J; Maldonado, R; Mico, JA; Roques, BP; Tejedor-Real, P | 1 |
| Lishmanov, IuB; Maslov, LN; Székely, JI | 1 |
| Chiappinelli, VA; Feng, C; McMahon, LL; Wolf, KM; Yum, L | 1 |
| Beal, MF; Penney, JB; Wüllner, U; Young, AB | 1 |
| Capasso, A; Carnuccio, R; D'Acquisto, F; Iuvone, T | 1 |
| Nylander, I; Terenius, L; Vlaskovska, M | 2 |
| Cheng, PY; Soong, Y; Szeto, HH; Wu, DL | 1 |
| Goodman, M; Malmberg, AB; Ro, S; Schiller, P; Yaksh, TL | 1 |
| Fan, LQ; Gioannini, TL; Hiller, JM; Simon, EJ; Wolinsky, T | 1 |
| Carr, JA; Gregg, KJ | 1 |
| Cupo, A; Garreau, I; Pejoan, C; Piot, JM; Zhao, Q | 1 |
| Dragatsis, I; Gerozissis, K; Papazafiri, P; Zioudrou, C | 1 |
| Bocheva, A; Dimitrov, E; Ivancheva, C; Pencheva, N; Radomirov, R | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M; Saitoh, A; Suzuki, T | 1 |
| Childers, SR; Selley, DE; Sim, LJ | 1 |
| Pan, JY; Tan, SJ; Tang, EH; Wei, ZY; Zhan, CY | 1 |
| Tripathi, A; Welch, SP | 1 |
| Donahoe, RM; Ketelsen, D; Madden, JJ; Oleson, D; Whaley, WL | 1 |
| Dubrovina, NI | 1 |
| Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Petit, A | 1 |
| Ableitner, A; Hassan, AH; Herz, A; Stein, C | 1 |
| Gabrilovac, J | 1 |
| Randić, M; Wang, RA | 1 |
| He, C; Shi, PT; Song, CY; Wei, YM; You, ZD | 1 |
| Fingerman, M; Nagabhushanam, R; Sarojini, R | 2 |
| Klitenick, MA; Wirtshafter, D | 1 |
| Kelly, MJ; Lagrange, AH; Rønnekleiv, OK | 1 |
| Gear, RW; Levine, JD | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Evans, CJ; Hales, TG; Law, PY; Loh, HH; Piros, ET; Prather, PL | 1 |
| Noble, F; Roques, BP | 1 |
| Donatini, A; Ferri, S; Lesa, G; Romualdi, P | 1 |
| Aoki, Y; Katao, Y; Katsumata, S; Minami, M; Nakagawa, T; Onogi, T; Satoh, M | 1 |
| Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Adams, JU; Li, S; Liu-Chen, LY; Yang, HH | 1 |
| Garzón, J; Martínez-Peña, Y; Sánchez-Blázquez, P | 2 |
| Glick, SD; Herrick-Davis, K; Pearl, SM; Teitler, M | 1 |
| Bidlack, JM; Chung, NN; Dooley, CT; Houghten, RA; Pasternak, GW; Schiller, PW; Wilkes, BC | 1 |
| Elliott, J; Lambert, DG; Smart, D; Traynor, JR | 2 |
| Kalentchuk, V; Kozlova, M | 1 |
| Daddona, MM; Haldar, J | 1 |
| Henriksen, SJ; Mayer, JH; Steffensen, SC | 1 |
| Il'Ina, AD; Klodt, PM; Maisky, AI; Zaitsev, SV | 1 |
| Ichikawa, T; Ikeda, K; Kobayashi, T; Kumanishi, T; Usui, H | 1 |
| Fournié-Zaluski, MC; Guilbaud, G; Kayser, V; Perrot, S; Roques, BP | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Hagi, K; Inaba, K; Muramatsu, S; Uno, K | 1 |
| Madamba, SG; Moore, SD; Schweitzer, P; Siggins, GR | 1 |
| North, RA; Tanaka, E | 1 |
| Ardid, D; Aumaitre, O; Betoin, F; Duchene-Marullaz, P; Eschalier, A; Herbet, A; Kemeny, JL; Lavarenne, J | 1 |
| Gozariu, L; Gozariu, MS; Orbai, P; Sandor, V; Schmidt-Gayk, H | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP | 2 |
| Carter, L; Schäfer, M; Stein, C | 1 |
| Desiraju, T; Nagaraja, TN; Raju, TR; Singh, J | 1 |
| Connelly, CD; Martinez, RP; Porreca, F; Raffa, RB; Schupsky, JJ | 1 |
| Barnard, EA; Benyhe, S; Borsodi, A; Simon, J; Wollemann, M | 1 |
| Jauzac, P; Polastron, J | 1 |
| Richter, JP; Snyman, JR; Sommers, DK | 1 |
| Gintzler, AR; Wang, L | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Laorden, ML; Micol, JA | 1 |
| Billington, D; MacKinnon, KL; Zuzel, KA | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O | 1 |
| Kwok, YN; McIntosh, C; Yago, V | 1 |
| Borsook, D; Comb, M; Falkowski, O; Hyman, SE; Rosen, H | 1 |
| Noble, F; Roques, BP; Smadja, C | 1 |
| Boersma, CJ; Pool, CW; Van Heerikhuize, JJ; Van Leeuwen, FW | 1 |
| Eisenberg, RM | 2 |
| Coenen, A; Lasoń, W; Przewłocka, B; Przewłocki, R; Van Luijtelaar, G | 1 |
| Blaschak, CJ; Johnson, PS; Moriwaki, A; Seidleck, BK; Surratt, CK; Uhl, GR; Wang, JB | 1 |
| Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H | 1 |
| Garty, M; Keren, O; Sarne, Y | 1 |
| Imai, N; Kashiki, M; Liang, CS; Woolf, PD | 1 |
| Benson, B; Dunn, AM; Rodriguez, RE; Wise, ME | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Bicknell, RJ; Douglas, AJ; Dye, S; Leng, G; Russell, JA | 1 |
| North, RA; Sugita, S | 1 |
| Adamo, EB; Di Giovanni, G; Marini, R; Mulè, F; Postorino, A; Serio, R | 1 |
| Coffield, JA; Miletic, V | 1 |
| Hiddinga, HJ; Isaak, DD; Lewis, RV | 1 |
| Jin, W; Lee, NM; Loh, HH; Thayer, SA | 1 |
| Sagratella, S; Scotti de Carolis, A | 1 |
| Higuchi, H; Kuo, CH; Miki, N; Nakano, K; Osugi, T | 1 |
| De Wet, EH; Oosthuizen, JM; Schall, R | 1 |
| Hasegawa, A; Nagamatsu, K; Tagawa, Y; Uchida, S | 1 |
| Colwell, DD; Kavaliers, M | 1 |
| Fu, R; Gaskill, MB; Iwasaki, Y; Robertson, GL; Saper, CB | 1 |
| De Vries, TJ; Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Mantelet, S; Pohl, M | 1 |
| Cui, Y; Kramarova, LI; Lee, TF; Wang, LC | 1 |
| Ishige, K; Ito, Y; Makimura, M; Murakoshi, Y | 1 |
| Lambert, NA; Wilson, WA | 1 |
| Iasnetsov, VV; Novikov, VE | 1 |
| Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 1 |
| Groenewegen, HJ; Jongen-Rĕlo, AL; Voorn, P | 1 |
| Dorow, J; Feller, DJ; Stuart, JF | 1 |
| Aloyo, VJ; Battisi, WP; Pazdalski, PS | 1 |
| Parenti, C; Scoto, GM | 1 |
| Shen, S; Yuan, XR; Zhu, SM | 1 |
| Brotchie, JM; Crossman, AR; Maneuf, YP; Mitchell, IJ | 1 |
| Rattan, AK; Tejwani, GA | 1 |
| Bachoo, M; Polosa, C; Zhang, C | 1 |
| Kondo, Y; Okajima, F; Tomura, H | 1 |
| Bürki, C; Ehrenberger, K; Felix, D | 1 |
| Miyamoto, Y; Portoghese, PS; Takemori, AE | 1 |
| Capron, A; Duvaux-Miret, O; Leung, MK; Stefano, GB | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Welch, SP | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Borsodi, A; Búzás, B; Friedmann, T; Fürst, Z; Schmidhammer, H | 1 |
| Desmeules, JA; Gacel, G; Guilbaud, G; Kayser, V; Roques, BP | 1 |
| Hanke, J; Jaros, PP; Willig, A | 1 |
| Fan, LQ; Gioannini, TL; Hiller, JM; Hyde, L; Ofri, D; Simon, EJ; Yao, YH | 1 |
| Desmeules, JA; Guilbaud, G; Kayser, V | 1 |
| Cheng, PY; Decena, JA; McCabe, S; Soong, Y; Szeto, HH; Wu, D | 1 |
| Aloyo, VJ; Harvey, JA; Romano, AG | 1 |
| Henion, PD; Landis, SC | 1 |
| Capogrossi, MC; Lakatta, EG; Spurgeon, HA; Xiao, RP | 1 |
| Goñalons, E; Jiménez, M; Martínez, V; Vergara, P | 1 |
| Avidor-Reiss, T; Bayewitch, M; Levy, R; Matus-Leibovitch, N; Nevo, I; Vogel, Z | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Laban, O; Marković, BM; Radulović, J; Stanojević, S; Vasiljević, T | 1 |
| Chaplan, SR; Lee, YW; Yaksh, TL | 1 |
| Gratton, A; Noel, MB | 1 |
| Ding, H; Wang, C; Zhang, T; Zheng, X | 1 |
| Dubrovina, NI; Ilyutchenok, RY | 1 |
| Carpenter, DO; Elekes, K; Kemenes, G; Leung, M; Rózsa, KS; Salánki, J; Stefano, G | 1 |
| Pasternak, GW; Rossi, GC; Standifer, KM | 1 |
| Aley, KO; Green, PG; Levine, JD | 1 |
| Howells, RD; Jin, J; Shahrestanifar, M; Wang, WW | 1 |
| Cowan, A; Hunter, JC; Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Wheeler-Aceto, H | 1 |
| Currie, KP; Fox, AP | 1 |
| Capasso, A; Di Giannuario, A; Loizzo, A; Pieretti, S; Sagratella, S; Sorrentino, L | 1 |
| Henriksen, SJ; Mayer, JH | 1 |
| Endoh, T; Suzuki, T | 2 |
| Aristova, VV; Baronets, VIu; Litvinova, SV; Panchenko, LF; Terebilina, NN | 1 |
| Gabrilovac, J; Ikic-Sutlic, M; Knezevic, N; Poljak, L | 1 |
| Ludbrook, J; Ventura, S | 1 |
| Potter, DE; Wang, D | 1 |
| Chieng, B; Christie, MJ; Connor, M | 1 |
| Bailey, EC; Bruce, DS; Hellgren, EC; Horton, ND; Jacobson, D; Oeltgen, PR; Setran, DP; Tramell, MS | 1 |
| Honkanen, A; Hyytiä, P; Korpi, ER; Sarviharju, M; Vilamo, L; Wegelius, K | 1 |
| Hall, TJ; Jagher, B; Schaeublin, M; Wiesenberg, I | 1 |
| Feigenbaum, JJ; Simantov, R | 1 |
| Cox, BM; Noble, F | 1 |
| Basbaum, AI; Botchkina, GI; Cho, HJ; Gogas, KR; Levine, JD | 1 |
| Feldman, PD; Parveen, N; Sezen, S | 1 |
| Etgen, AM; Vathy, I | 1 |
| Giacchino, JL; Henriksen, SJ | 2 |
| Casares, F; Liu, U; Stefano, GB | 1 |
| Audet, RM; Butterworth, RF; de Waele, JP; Leong, DK | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Bodnar, RJ; Cole, JL; Leventhal, L | 1 |
| Fields, HL; Pan, ZZ | 1 |
| Mokha, SS; Wang, XM | 1 |
| Fukunaga, Y; Inoue, N; Kishioka, S; Nishida, S; Yamamoto, H | 1 |
| Kaputlu, I; Oğütman, C; Sadan, G | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Crain, SM; Shen, KF | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Bodor, N; Prokai, L; Prokai-Tatrai, K | 1 |
| Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM | 1 |
| Mokha, SS; Wang, XM; Yan, JQ; Zhang, KM | 1 |
| Aley, KO; Levine, JD | 2 |
| Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P | 1 |
| Peter, Y; Pick, CG; Schreiber, S; Weizman, R | 1 |
| Breivogel, CS; Childers, SR; Nestler, EJ; Selley, DE | 1 |
| Helyes, Z; Pintér, E; Szolcsányi, J | 1 |
| Das, KP; Hong, JS; Sanders, VM | 1 |
| Bodnar, RJ; Ruegg, H; Yu, WZ | 1 |
| Breivogel, CS; Childers, SR; Selley, DE | 1 |
| Berkmiller, G; Falk, W; Frauenholz, T; Herrmann, M; Lang, B; Schölmerich, J; Straub, RH | 1 |
| Boraníc, M; Breljak, D; Gabrilovac, J; Krizanac-Bengez, L; Marotti, T | 1 |
| Chen, JJ; Dymshitz, J; Vasko, MR | 1 |
| Bombelli, R; Cosentino, M; Ferrari, M; Frigo, G; Giaroni, C; Lecchini, S; Marino, F; Rasini, E | 1 |
| Khan, S; Smith, ME | 1 |
| Capogrossi, MC; Lakatta, EG; Pepe, S; Spurgeon, HA; Xiao, RP | 1 |
| Altschuld, R; Hohl, C; Lakatta, EG; Pepe, S; Xiao, RP | 1 |
| Bhatia, SC; Manchanda, SK; Nayar, U; Saha, SN | 1 |
| Andrievskiĭ, AG; Zaporozhchenko, MB | 1 |
| Matsuda, T; Mori, M; Tsushima, H | 1 |
| Kuraishi, Y; Tohda, C; Yamaguchi, T | 1 |
| Kavaliers, M; Ossenkopp, KP; Prato, FS; Thomas, AW | 1 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Kramer, TH; Porreca, F | 1 |
| Hosoki, R; Otsuka, M; Suzuki, H; Yanagisawa, M; Yoshioka, K | 1 |
| Fields, A; Sarne, Y | 1 |
| Bugajski, J; Gadek-Michalska, A | 1 |
| Abbruscato, TJ; Davis, TP; Hruby, VJ; Thomas, SA | 1 |
| Krylatov, AV; Lishmanov, IuB; Maslov, LN | 1 |
| George, SR; O'Dowd, BF; Pak, Y | 1 |
| Hocherman, SD; Randić, M | 1 |
| Bontempi, B; Sharp, FR | 1 |
| Georgoussi, Z; Merkouris, M; Milligan, G; Mullaney, I | 1 |
| Medzihradsky, F; Yabaluri, N | 1 |
| Akil, H; Gutstein, HB; Mansour, A; Rubie, EA; Woodgett, JR | 1 |
| Gauthier, CA; Gonzales, GR; Minor, LD; Paul, D | 1 |
| Childers, SR; Sim, LJ | 1 |
| Kubo, K; Sasaki, T; Torii, M | 1 |
| Beglan, CL; Blaschak, CJ; Hirshbein, LD; Seidleck, BK; Spivak, CE; Surratt, CK; Uhl, GR | 1 |
| Brodin, E; Fried, K; Gustafsson, H; Stiller, CO | 1 |
| Herlenius, EA; Lindahl, SG; Takita, K; Yamamoto, Y | 1 |
| Budai, D; Fields, HL | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Hauser, KF; Stiene-Martin, A; Zhou, R | 1 |
| Gerendai, I | 1 |
| Childers, SR; Liu, Q; Selley, DE; Sim, LJ | 1 |
| Carney, JM; Harris-White, ME; Hauser, KF; Jackson, JA; Opanashuk, LA | 1 |
| Fukunaga, Y; Inoue, N; Kishioka, S; Miyamoto, M; Nishida, S; Yamamoto, H | 1 |
| Mash, DC; Pablo, JP | 1 |
| Bender, MA; Glorioso, JC; Kang, W; Wilson, MA; Wilson, SP | 1 |
| Adeghate, E; Djali, PK; Singh, J | 1 |
| Dichter, MA; Reisine, T; Tallent, M | 1 |
| Moises, HC; Rusin, KI | 1 |
| Carabelli, V; Carbone, E; Carra, I | 1 |
| Brown, GP; Pasternak, GW | 1 |
| Satyapriya, A; Sheu, MJ; Sribanditmongkol, P; Tejwani, GA | 1 |
| Carbone, E; Clementi, F; Codignola, A; Missale, C; Sher, E; Spano, P | 1 |
| Jankowska, E; Schomburg, ED | 1 |
| Fukuda, K; Kato, S; Mima, H; Mori, K; Morikawa, H; Shoda, T | 1 |
| Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G | 1 |
| Behbehani, MM; Hall, CW | 1 |
| Franck, J; Lindholm, S; Raaschou, P | 1 |
| Heder, G; Melzig, MF; Siems, WE; Zipper, J | 1 |
| Osumi, Y; Yokotani, K | 1 |
| Becker, A; Grecksch, G; Hoellt, V; Schroeder, H; Schroeder, U | 1 |
| Capasso, A; Pinto, A; Sorrentino, L | 1 |
| Gilmore, DP; Wilson, CA; Yilmaz, B | 1 |
| Fukaya, Y; Kameoka, H; Shiraiwa, Y; Shishido, K; Yamaguchi, O; Yokota, T | 1 |
| Finberg, RW; Heagy, W; Lopez, P; Teng, E | 1 |
| Chu, X; Li, P; Wang, JQ; Xu, N | 1 |
| Fujimoto, JM; Gorny, JM; Rady, JJ | 1 |
| Fukunaga, Y; Inoue, N; Kishioka, S; Miyamoto, M; Yamamoto, H | 1 |
| Kramer, HK; Simon, EJ | 1 |
| Gioannini, TL; Hiller, JM; Onoprishvili, I; Simon, EJ | 1 |
| Liu, H; Mazarati, A; Wasterlain, C | 1 |
| Joshi, S; Lee, JW; Wong, YH | 1 |
| Arcaya, JL; Cano, G; Gómez, G; Maixner, W; Suárez-Roca, H | 1 |
| Chavkin, C; Jin, W | 1 |
| Fuchs, PN; Raja, SN; Roza, C; Sora, I; Uhl, G | 1 |
| Bhandari, RN; Clarke, RW; Ogilvie, J | 1 |
| Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T | 1 |
| Hallermann, S; Müller, W; Swandulla, D | 1 |
| Chen, C; de Riel, JK; Li, JG; Liu-Chen, LY; Ozdener, F; Weinstein, H; Xu, W | 1 |
| Ang, KK; Arnolda, LF; Chalmers, JP; Llewellyn-Smith, IJ; McRitchie, RJ; Minson, JB; Pilowsky, PM | 1 |
| Környei, JL; Kovács, KA; Oszter, A; Rao, CV; Vértes, M; Vértes, Z | 1 |
| Allouche, S; Jauzac, P; Marie, N; Roussel, M | 1 |
| Gerfen, CR; Steiner, H | 1 |
| Fujimura, T; Kastin, AJ; Katsuyama, S; Murayama, K; Sakurada, S; Sakurada, T; Ueda, H; Yuki, M; Zadina, JE | 1 |
| Chiou, LC; Huang, LY | 1 |
| Kang, W; Wilson, MA; Wilson, SP | 2 |
| Arakawa, K; Furuse, M; Saito, N; Sasaki, T; Shimada, K | 1 |
| Besson, MJ; Mavridis, M | 1 |
| Hamra, M; Kunze, DL; McNeil, RS; Runciman, M | 1 |
| Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L; SanMartín, S | 1 |
| Bakalkin, G; Derjabin, V; Hauser, KF; Nazarevskaja, G; Reznikov, K; Trunova, Y | 1 |
| Colombo, G; Fadda, P; Fratta, W; Tronci, S | 1 |
| Babey, AM; Cavalli, A; Loh, HH | 1 |
| Cavani, F; Mattocks, D; Nieto-Fernandez, FE; Salzet, M; Stefano, GB | 1 |
| Cutler, DJ; Mason, R; Mundey, MK | 1 |
| Chien, GL; Takasaki, Y; van Winkle, DM; Wolff, RA | 1 |
| Cui, RY; Jiang, CL; Liu, XY; Lu, CL; Son, LX; Sun, LY; Wang, YX; You, ZD | 1 |
| Elde, RP; Hauser, KF; Houdi, AA; Maxson, W; Turbek, CS | 1 |
| Endo, K; Yawo, H | 1 |
| Jiang, CL; Liu, XY; Lu, CL; Wang, AJ; Wang, YX; Xu, D; You, ZD | 1 |
| Chen, X; Harris, KH; Jhamandas, JH; Zidichouski, JA | 1 |
| Brené, S; Olson, L; Thorén, P; Werme, M | 1 |
| Chen, ZW; Han, JS; Wang, Y; Yang, K | 1 |
| Boudinot, E; Denavit-Saubié, M; Fournié-Zaluski, M; Foutz, AS; Morin-Surun, M; Roques, BP | 1 |
| Dun, Y; Hao, YB; Wu, YX; Yang, SP; Zhang, Y | 1 |
| Hazato, T; Honda, M; Ono, H; Yamamoto, Y; Yamazaki, T | 1 |
| Lipkowski, AW; Narita, M; Suzuki, T; Yamazaki, M | 1 |
| Aguilar-Santelises, M; Bakalkin, G; Cebers, G; Gileva, I; Hauser, KF; Hoon Goh, B; Reznikov, K; Tan-No, K; Terenius, L; Yakovleva, T | 1 |
| Blehar, DJ; Carraway, RE; Dickson, EW; Heard, SO; Przyklenk, K; Steinberg, G | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE | 1 |
| Hazato, T; Honda, M; Matsuura, T; Miyagi, T; Okutsu, H; Ono, H; Yamamoto, Y | 1 |
| Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB | 1 |
| Ahmad, S; Banville, D; Cao, J; Dray, A; Fortin, Y; Gosselin, M; Grazzini, E; Groblewski, T; Hoffert, C; Labarre, M; Lembo, PM; O'Donnell, D; Payza, K; Pelletier, M; Roy, MO; Schmidt, R; Shen, SH; Ström, P; Walker, P; Zhang, J | 1 |
| Adeghate, E; Ponery, AS | 1 |
| Eguchi, M; Kahn, M; Lee, MS; Shea, JP; Shen, RY | 1 |
| Bowsher, D; Campbell, J; Haggett, C; Haywar, M; Lahuerta, J; Mumford, J; Peach, B; Venn, D | 1 |
| Andrén, PE; Gunne, L; Klintenberg, R; Svenningsson, P | 1 |
| Martin-Kleiner, I | 1 |
| Gabryel, B; Herman, ZS; Kowalski, J; Łabuzek, K | 1 |
| Fink, DJ; Glorioso, JC; Goins, W; Hao, S; Mata, M | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Brecha, NC; Kohlmeier, SE; Minnis, JG; Patierno, S; Sternini, C; Tonini, M | 1 |
| Gross, GJ; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stefano, GB; Tam, SW | 1 |
| Göcze, PM; Környei, JL; Kovács, KA; Vértes, M; Vértes, Z | 1 |
| Kozyrev, SA; Nikitin, VP; Shevelkin, AV | 1 |
| Christie, MJ; Hack, SP; Vaughan, CW | 1 |
| Brailoiu, GC; Dun, NJ; Ohtubo, Y; Wu, SY | 1 |
| Carrión, AM; de los Santos-Arteaga, M; Delgado-García, JM; Fontanella, GH; Sierra-Domínguez, SA | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Miletić, T; Radulović, J; Stanojević, S; Vujić, V | 1 |
| Gomma, M; Osman, AM; Saad, AH | 1 |
| Bhatia, SC; Nayar, U; Saha, SN | 1 |
| Fujimoto, JM; Leitermann, RJ; Sun, HS; Thompson, J; Tseng, LF; Wu, HE | 1 |
| Cox, ML; Welch, SP | 1 |
| Gutkowska, J; Izdebski, J; Jankowski, M; Mukaddam-Daher, S; Pawlak, D | 1 |
| Arend, A; Aunapuu, M; Bourin, M; Kõks, S; Kurrikoff, K; Matsui, T; Vasar, E | 1 |
| Hong, Y; Huang, H; Zeng, X | 1 |
| Clithero, AD; Leitermann, RJ; Sun, HS; Terashvili, M; Tseng, LF; Wu, HE | 1 |
| Brezovec, S; Ferrero, EA; Lorenzon, S | 1 |
| Bansal, V; Fahim, M; Hanif, K; Pasha, S; Pavar, MC | 1 |
| Goldstein, JM; Malick, JB | 1 |
| Bourgoin, S; Cesselin, F; Hamon, M; Kayser, V; Latrémolière, A; Mauborgne, A; Meunier, A; Pohl, M | 1 |
| Lam, HA; Maidment, NT; Narayanan, S; Shoblock, J; Skoubis, PD | 1 |
| Brunton, PJ; Douglas, AJ; Ma, S; Meddle, SL; Ochedalski, T; Russell, JA | 1 |
| Cordonnier, L; Noble, F; Roques, BP; Sanchez, M | 1 |
| Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K | 1 |
| Guen, SL; Kieffer, BL; Nieto, MM; Noble, F; Roques, BP | 1 |
| Hayward, MD; Low, MJ | 1 |
| Hsiao, I; Lin, VW; Longhurst, JC; Zhou Yi Syuu, W | 1 |
| Lin, BC; Liu, WY; Song, CY; Yang, J | 1 |
| Farrell, PA; Loomis, JL; Rodd, DW | 1 |
| Baugh, MM; Bradford, CS; Moore, FL; Stanley, DJ; Walthers, EA | 1 |
| Adrian, R; Baratta, J; Koob, GF; Lauterborn, JC; Solbrig, MV | 1 |
| Bezard, E; Bilbao, A; Chen, JF; Cippitelli, A; Granado, N; Martín, AB; Moratalla, R; Navarro, M; Ortiz, O; Rodríguez de Fonseca, F | 1 |
| Ahmad, T; Ahmed, M; Bergström, J; Kreicbergs, A; Li, J; Spetea, M | 1 |
| Aşkin, A; Camlica, Y; Cömelekoğlu, U | 1 |
| Berridge, KC; Smith, KS | 1 |
| Gabaeva, MV; Kost, NV; Makarenkova, VP; Meshavkin, VK; Sokolov, OIu; Zazulia, AA | 1 |
| Alloui, A; Baron, A; Blondeau, N; Cupo, A; Diochot, S; Eschalier, A; Escoubas, P; Gélot, A; Heurteaux, C; Lazdunski, M; Mazzuca, M; Voilley, N; Zimmer, A; Zimmer, AM | 1 |
| Burger, MC; Cramb, DT; Dahms, TE; Massotte, D; Swift, JL | 1 |
| Maidment, NT; Shoblock, JR | 1 |
| Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A | 1 |
| Kiguchi, N; Kishioka, S; Maeda, T; Ozaki, M; Tsuruga, M; Yamamoto, A; Yamamoto, C | 1 |
| Barontini, M; Cigorraga, SB; Figuerola, Mde L; Levin, G; Pellizzari, EH | 1 |
| Fink, DJ; Hao, S; Hu, J | 1 |
| Bajusz, S; Benyhe, S; Bojnik, E; Borsodi, A; Magyar, A; Tóth, G | 1 |
| Lipkowski, AW; Szereda-Przestaszewska, M; Wojciechowski, P | 1 |
| Bing, G; Jang, CG; Kim, HC; Koo, KH; Nabeshima, T; Oh, CH; Oh, KW; Park, DH; Shin, EJ; Yamada, K | 1 |
| Ionov, ID; Pushinskaya, II | 1 |
| Friedman, TC; Hamid, A; Lutfy, K; Marquez, P; Nguyen, K; Parikh, D; Tseng, A | 1 |
| Dibaj, P; Schomburg, ED; Steffens, H | 1 |
| Hao, F; Li, P; Liang, JY; Pan, YJ; Qiu, PY; Wang, DX; Yang, J; Zhang, J | 1 |
| Kennedy, RT; Li, Q; Mabrouk, OS; Song, P | 1 |
| Bagosi, Z; Csabafi, K; Jászberényi, M; Telegdy, G; Tóth, G; Wollemann, M | 1 |
| Guo, Q; Huang, C; Pan, Y; Yan, J; Yang, Y; Zou, W | 1 |
| Brunetti, L; Chiavaroli, A; Di Nisio, C; Leone, S; Mollica, A; Orlando, G; Vacca, M | 1 |
| Borst, DW; Ganji, PN; Kumar, S; Nagaraju, GP; Song, H; von Kalm, L | 1 |
| de Groat, WC; Glorioso, JC; Goins, WF; Goss, JR; Krisky, DM; Nishizawa, O; Oguchi, T; Wolfe, D; Yokoyama, H; Yoshimura, N | 1 |
| Cordes, MA; Kelm-Nelson, CA; Riters, LV; Stevenson, SA | 1 |
| Garg, M; Hamid, A; Lutfy, K; Marquez, P; Nguyen, K; Tseng, A | 1 |
| Bilsky, EJ; Cain, JP; Hruby, VJ; Hu, J; Kumirov, VK; Lee, YS; Podolsky, AT; Sandweiss, A; Vanderah, TW; Vardanyan, RS | 1 |
| Cepeda, C; Cui, Y; Evans, CJ; Ge, W; James, AS; Jentsch, JD; Kieffer, BL; Levine, MS; Maidment, NT; Mittal, N; Murphy, NP; Ostlund, SB; Park, CS; Roberts, KW; Sun, YE; Walwyn, WM; Yang, XW | 1 |
| Gugusheff, JR; Muhlhausler, BS; Ong, ZY | 1 |
| Williams, JT | 1 |
| Li, G; Li, X; Ma, C; Wan, Q; Wu, S; Yu, D; Zhang, B; Zhou, R | 1 |
| Asai, M; Benítez-King, G; Escobar, C; Solís-Chagoyán, H; Valdés-Tovar, M | 1 |
| Assis, MA; Cancela, LM; García-Keller, C; Mascó, DH; Mongi-Bragato, B; Virgolini, MB; Zamponi, E; Zimmer, A | 1 |
| Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F; Yamamoto, C | 1 |
| Bellinger, LL; Kramer, PR; Umorin, M | 1 |
| Bowman, BR; Goodchild, AK | 1 |
| Chizhmakov, IV; Krishtal, OA; Kulyk, VB; Maximyuk, OP; Volkova, TM | 1 |
| Benhye, S; Bochynska-Czyz, M; Bujalska-Zadrozny, M; Lesniak, A; Lipkowski, AW; Misicka, A; Sacharczuk, M | 1 |
| Li, H; Sun, Q; Sun, Y; Tian, Y; Zhang, D | 1 |
| Cai, H; Cui, L; Dong, J; Li, J; Qian, C; Qu, Y; Sun, F; Wang, H; Wang, Y | 1 |
| Liu, X; Ma, M; Wang, K; Wang, R; Wang, Y; Wei, S; Zhang, X; Zhao, L; Zhou, J | 1 |
| Dincer, S; Güney, Ş; İlhan, AŞ | 1 |
| Al-Madol, M; Khalefa, BI; Li, L; Mousa, SA; Schäfer, M; Shaqura, M; Treskatsch, S | 1 |
| Candeletti, S; Darcq, E; De Gregorio, D; Gobbi, G; He, Q; Kieffer, BL; Lopez-Canul, M; Luongo, L; Pearl-Dowler, L; Posa, L; Romualdi, P; Rullo, L | 1 |
| Asokan, M; Choi, IB; Dobbs, LK; Le, NN; Matsumura, K; Natividad, LA; Nicot, A | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
54 review(s) available for enkephalin, leucine and naloxone
| Article | Year |
|---|---|
[Morphine analgesia: neurobiologic data].
Topics: Analgesia; Animals; Axons; Brain Stem; Cats; Depression, Chemical; Electric Stimulation; Electronarcosis; Enkephalins; Morphine; Naloxone; Neurons; Rats; Receptors, Opioid; Serotonin; Spinal Cord; Substance P; Substantia Gelatinosa; Synaptic Transmission | 1978 |
[Endorphins--endogenous peptides with morphine-like effects. 2. Biological importance, clinical apsects].
Topics: Behavior; Body Temperature Regulation; Drug Tolerance; Endorphins; Enkephalins; Epilepsy; Female; Gastrointestinal Motility; Humans; Learning; Naloxone; Pain Insensitivity, Congenital; Pregnancy; Stress, Psychological | 1978 |
The opiate receptor.
Topics: Animals; Binding, Competitive; Brain; Cattle; Caudate Nucleus; Cell Membrane; Dogs; Enkephalins; Kinetics; Morphine Derivatives; Naloxone; Pituitary Gland; Radioimmunoassay; Radioligand Assay; Receptors, Opioid | 1977 |
[Characteristics of acupuncture analgesia, review of the articles on stimulation produced analgesia and morphine like substance (author's transl)].
Topics: Acupuncture Therapy; Analgesia; Animals; Biogenic Amines; Cats; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; Haplorhini; Humans; Morphine; Naloxone; Raphe Nuclei; Rats; Receptors, Opioid; Spinal Cord | 1978 |
[Enkephalins].
Topics: Animals; Cyclic AMP; Endorphins; Enkephalins; Humans; Naloxone; Receptors, Opioid; Spinal Cord; Synaptic Transmission | 1978 |
Endogenous pain control mechanisms: review and hypothesis.
Topics: Analgesia; Animals; Biogenic Amines; Brain; Brain Stem; Cats; Electric Stimulation; Enkephalins; Humans; Models, Neurological; Naloxone; Narcotics; Neural Inhibition; Neural Pathways; Pain; Raphe Nuclei; Rats; Serotonin; Spinal Cord; Spinal Cord Diseases; Synaptic Transmission | 1978 |
Endogenous opiates: through 1978.
Topics: Animals; Brain; Brain Mapping; Drug Tolerance; Electroencephalography; Endorphins; Enkephalins; Humans; Learning; Mental Disorders; Mental Recall; Morphine; Naloxone; Nociceptors; Receptors, Opioid; Synaptic Transmission | 1979 |
Central pain mechanisms.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Cats; Electric Stimulation; Endorphins; Enkephalins; Humans; Mice; Naloxone; Neural Inhibition; Nociceptors; Pain; Pain, Intractable; Rats; Spinal Cord; Spinothalamic Tracts; Substance P; Substantia Gelatinosa | 1978 |
Endorphins--the first three years.
Topics: Antibodies; Central Nervous System; Circadian Rhythm; Digestive System; Endorphins; Enkephalins; History, 20th Century; Humans; Immunologic Techniques; Limbic System; Naloxone; Pituitary Gland, Anterior; Tissue Distribution | 1979 |
Striatonigral prodynorphin: a model system for understanding opioid peptide function.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Dopamine; Enkephalins; Hydroxydopamines; Locomotion; Motor Neurons; Movement; Naloxone; Neural Pathways; Oxidopamine; Protein Precursors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Substantia Nigra | 1990 |
Enkephalins and learning and memory: a review of evidence for a site of action outside the blood-brain barrier.
Topics: Adrenal Glands; Animals; Conditioning, Classical; Enkephalins; Learning; Memory; Mice; Naloxone; Quaternary Ammonium Compounds; Rats; Receptors, Opioid | 1988 |
Endorphins: what are they? How are they measured? What is their role in exercise?
Topics: Adrenocorticotropic Hormone; Animals; Dynorphins; Endorphins; Enkephalins; Follicle Stimulating Hormone; Growth Hormone; Hemodynamics; Humans; Luteinizing Hormone; Naloxone; Oxygen Consumption; Physical Exertion; Prolactin; Radioimmunoassay; Receptors, Opioid; Thyrotropin | 1985 |
The changing nature of pain control. Clinical aspects of endorphins and enkephalins.
Topics: Acupuncture Therapy; Amino Acids; Analgesics, Opioid; Animals; Differential Threshold; Electric Stimulation; Endorphins; Enkephalins; Humans; Hypnosis; Naloxone; Nitrous Oxide; Pain; Receptors, Opioid | 1985 |
Multiple mu opiate receptors.
Topics: Aging; Analgesia; Animals; Autoradiography; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Morphine; Naloxone; Neurotransmitter Agents; Phylogeny; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Substance-Related Disorders; Tissue Distribution | 1986 |
Functional response of multiple opioid systems to chronic arthritic pain in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arthritis; Arthritis, Experimental; Benzomorphans; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Morphine; Naloxone; Nociceptors; Pain; Pituitary Gland, Anterior; Protein Precursors; Pyrrolidines; Rats; Receptors, Opioid; Sensory Thresholds; Spinal Cord; Thalamus | 1986 |
Opioid receptor mechanisms in the rat hippocampus.
Topics: Animals; Dynorphins; Electrophysiology; Enkephalin, Leucine; gamma-Aminobutyric Acid; Hippocampus; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Opioids and breathing.
Topics: Adult; Anesthesia; Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; GABA Antagonists; Humans; Hypoxia; Morphine; Naloxone; Narcotics; Pulmonary Circulation; Respiration; Smoking | 1985 |
The role of opioids in the endocrine function of the pancreas.
Topics: Animals; beta-Endorphin; Biomechanical Phenomena; Chlorpropamide; Dogs; Eating; Endocrine Glands; Endorphins; Enkephalins; Ethanol; Flushing; Guinea Pigs; Humans; Islets of Langerhans; Male; Morphine; Naloxone; Pancreas; Pancreatic Hormones; Peptides; Protein Precursors; Rats; Sheep | 1986 |
[Endorphins, enkephalins and their antagonists in clinical practice (review of the literature)].
Topics: Adrenal Gland Diseases; Analgesia; Animals; Endorphins; Enkephalins; Humans; Hyperpituitarism; Hypothalamo-Hypophyseal System; Mice; Naloxone; Pituitary-Adrenal System; Rats; Receptors, Opioid | 1985 |
Neuroendocrinology of opioid peptides and their role in the control of gonadotropin and prolactin secretion.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Cushing Syndrome; DNA, Recombinant; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Gonadotropins; Humans; Hypothalamus; Luteinizing Hormone; Menstrual Cycle; Naloxone; Ovary; Pituitary Hormone-Releasing Hormones; Prolactin; Receptors, Opioid | 1985 |
[Enkephalinergic receptors at the level of the lower urinary tract].
Topics: Enkephalins; Humans; Male; Morphine Derivatives; Naloxone; Prostate; Receptors, Opioid; Synaptic Transmission; Urinary Bladder; Urinary Tract; Urinary Tract Physiological Phenomena; Urodynamics | 1985 |
[Enkephalinergic regulation of cardiovascular centers].
Topics: Animals; Blood Pressure; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Dextromoramide; Dogs; Enkephalin, Methionine; Enkephalins; Heart Rate; Medulla Oblongata; Naloxone; Naltrexone; Nervous System Physiological Phenomena; Pressoreceptors; Rats; Receptors, Opioid; Reflex; Reticular Formation; Sympathetic Nervous System; Vagus Nerve; Vasomotor System | 1985 |
Endogenous opioids and their receptors. Evidence for involvement in the postictal effects of electroconvulsive shock.
Topics: Animals; Anticonvulsants; Autonomic Nervous System; Blood Pressure; Brain; Diprenorphine; Drug Tolerance; Electroconvulsive Therapy; Electroencephalography; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Morphine; Naloxone; Pain; Pituitary Gland; Pressoreceptors; Rats; Receptors, Opioid; Sensory Thresholds; Tritium | 1986 |
Endogenous opioid peptides and hypothalamo-pituitary function.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Endorphins; Enkephalins; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Morphine; Naloxone; Prolactin; Rats; Stress, Physiological; Thyrotropin; Vasopressins | 1986 |
Renal opiate receptor mediation of renin secretion to renal nerve stimulation in the dog.
Topics: Animals; Dogs; Electric Stimulation; Enkephalin, Leucine; Female; Kidney; Male; Naloxone; Nervous System Physiological Phenomena; Phentolamine; Propranolol; Receptors, Opioid; Renin | 1986 |
Multiple morphine and enkephalin receptors: biochemical and pharmacological aspects.
Topics: Analgesia; Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Mice; Morphine; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration | 1986 |
Multiple endogenous opiate and non-opiate analgesia systems: evidence of their existence and clinical implications.
Topics: Acupuncture Therapy; Analgesia; Animals; Cholecystokinin; Conditioning, Classical; Desipramine; Dimethyl Sulfoxide; Drug Interactions; Electroshock; Endorphins; Enkephalin, Leucine; Mecamylamine; Morphine; N-Methylscopolamine; Naloxone; Naltrexone; Norepinephrine; Proglumide; Rats; Receptors, Cell Surface; Receptors, Cholecystokinin; Scopolamine; Scopolamine Derivatives; Serotonin; Spinal Cord | 1986 |
Enkephalins, other endogenous opioids and colonic motility in dog and man.
Topics: Animals; Central Nervous System; Colon; Dogs; Endorphins; Enkephalins; Gastrointestinal Motility; Humans; In Vitro Techniques; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Species Specificity; Thiorphan; Tiopronin | 1987 |
Opioids and stress in man.
Topics: Endorphins; Enkephalins; Humans; Naloxone; Stress, Physiological | 1988 |
The opioid-induced desensitization (tolerance) in neuroblastoma x glioma NG 108-15 hybrid cells: results from receptor uncoupling.
Topics: Animals; Bacterial Toxins; Carbachol; Cell Membrane; Cyclic AMP; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Mice; Naloxone; Narcotics; Neuroblastoma; Norepinephrine; Prostaglandins E; Rats; Receptors, Opioid; Virulence Factors, Bordetella | 1984 |
Enkephalins as transmitters in the central nervous system.
Topics: Animals; Brain; Cats; Electric Stimulation; Endorphins; Enkephalins; Humans; Immune Sera; Naloxone; Neurons; Neurotransmitter Agents; Rats; Skin; Spinal Cord | 1980 |
Mechanisms of opiate analgesia and the role of endorphins in pain suppression.
Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Endorphins; Enkephalins; Humans; Migraine Disorders; Naloxone; Neural Pathways; Norepinephrine; Pain; Receptors, Opioid; Sensory Thresholds; Serotonin; Spinal Cord | 1982 |
[Neuropeptide role in the etiology, pathogenesis and clinical aspects of mental diseases].
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Depressive Disorder; Drug Therapy, Combination; Endorphins; Enkephalins; Humans; Mental Disorders; Naloxone; Naltrexone; Nerve Tissue Proteins; Pituitary Hormones; Psychotropic Drugs; Schizophrenia; Substance-Related Disorders; Vasopressins | 1984 |
Multiple opioid receptor systems in brain and spinal cord: Part I.
Topics: Animals; Autoradiography; Bacterial Outer Membrane Proteins; beta-Endorphin; Binding Sites; Binding, Competitive; Biological Assay; Brain Chemistry; Dynorphins; Endorphins; Enkephalins; Humans; In Vitro Techniques; Ligands; Magnesium; Naloxone; Narcotics; Porins; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Receptors, Virus; Spinal Cord; Structure-Activity Relationship | 1984 |
An enkephalinergic gating system involved in nociception?
Topics: Animals; Endorphins; Enkephalins; Glutamates; Naloxone; Neurons; Pain; Spinal Cord; Substance P; Substantia Gelatinosa | 1980 |
Opioid peptides.
Topics: Analgesics; Animals; beta-Lipotropin; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Digestive System; Electroencephalography; Endorphins; Enkephalins; Humans; Morphine; Naloxone; Peptides; Receptors, Opioid; Spinal Cord; Substance-Related Disorders | 1980 |
Influence of endogenous opiates on anterior pituitary function.
Topics: Adrenocorticotropic Hormone; Animals; Endorphins; Enkephalins; Gonadotropins, Pituitary; Growth Hormone; Male; Naloxone; Pituitary Gland, Anterior; Pituitary Hormones, Anterior; Pituitary Hormones, Posterior; Prolactin; Rats; Secretory Rate; Thyrotropin | 1980 |
Characteristics of peptide and alkaloid opiate binding sites in brain and peripheral tissues.
Topics: Adrenal Medulla; Animals; Brain; Corpus Striatum; Dihydromorphine; Endorphins; Enkephalins; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Receptors, Opioid; Vas Deferens | 1980 |
The role of opioid peptides in memory and learning.
Topics: Amnesia; Animals; beta-Endorphin; Brain; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Learning; Memory; Naloxone; Naltrexone; Norepinephrine; Rats | 1980 |
The neuroendocrinology of opioid peptides.
Topics: Adrenocorticotropic Hormone; Animals; Dogs; Endorphins; Enkephalins; Gonadotropins, Pituitary; Growth Hormone; Humans; Naloxone; Pituitary Hormones; Pituitary Hormones, Posterior; Prolactin; Rats; Thyrotropin | 1983 |
Cardiovascular effects of endogenous opiate systems.
Topics: Animals; Brain; Brain Ischemia; Cardiovascular Physiological Phenomena; Cardiovascular System; Endorphins; Enkephalins; Humans; Hypertension; Hypotension; Morphine; Naloxone; Pressoreceptors; Receptors, Opioid; Reflex; Shock; Shock, Hemorrhagic; Shock, Septic; Spinal Cord Injuries; Thyrotropin-Releasing Hormone | 1983 |
Endogenous opioids: biology and function.
Topics: Adrenal Medulla; Analgesia; Animals; Behavior; Blood Pressure; Brain; Cardiovascular Physiological Phenomena; Drug Tolerance; Endocrine Glands; Endorphins; Enkephalins; Female; Humans; Morphine; Naloxone; Pain; Pituitary Gland; Pituitary Hormones, Anterior; Pregnancy; Pro-Opiomelanocortin; Protein Precursors; Protein Processing, Post-Translational; Receptors, Opioid; Shock; Spinal Cord; Stress, Physiological; Tissue Distribution | 1984 |
Multiple mechanisms of withdrawal from opioid drugs.
Topics: Acetylcholine; Adenine Nucleotides; Animals; Benzodiazepines; Calcium; Calmodulin; Clonidine; Conditioning, Psychological; Cyclic GMP; Dopamine; Drug Tolerance; Enkephalins; Fear; gamma-Aminobutyric Acid; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Norepinephrine; Protein Conformation; Receptors, Opioid; Serotonin; Substance Withdrawal Syndrome | 1984 |
Endorphins and psychiatry: pre-clinical perspectives.
Topics: Animals; Brain Chemistry; Depression, Chemical; Endorphins; Enkephalins; Hippocampus; Humans; Naloxone; Neurons; Pituitary Hormones, Anterior; Pro-Opiomelanocortin; Protein Precursors; Psychotic Disorders; Pyramidal Tracts; Rats; Receptors, Opioid | 1984 |
Minireview. Benzodiazepine-opiate antagonist interactions in relation to feeding and drinking behavior.
Topics: Animals; Benzodiazepines; Corpus Striatum; Drinking Behavior; Enkephalins; Feeding Behavior; Food Deprivation; Humans; Hyperphagia; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Reward; Thirst | 1983 |
Electrophysiology of opioid peptides and sensory systems.
Topics: Action Potentials; Animals; Cats; Electrophysiology; Enkephalins; Hippocampus; Humans; Naloxone; Neural Inhibition; Neurons; Olfactory Bulb; Rats; Reflex; Retina; Spinal Cord | 1983 |
Behavioural effects of opioid peptides.
Topics: Animals; Behavior; Behavior, Animal; Drug Tolerance; Endorphins; Enkephalins; Euphoria; Humans; Learning; Memory; Mood Disorders; Naloxone; Opioid-Related Disorders; Rats; Schizophrenia | 1983 |
Anaesthetic drugs: electrophysiological bases of their conduction blocking effect.
Topics: Anesthetics; Anesthetics, Local; Animals; Barbiturates; Electrophysiology; Enkephalins; Humans; Ketamine; Naloxone; Neural Conduction; Receptors, Drug | 1983 |
Opioid peptides and central control of blood pressure.
Topics: Adolescent; Adult; Animals; Blood Pressure; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Male; Naloxone; Pressoreceptors; Rabbits; Reflex | 1984 |
Endorphins and exercise.
Topics: Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Growth Hormone; Hormones; Humans; Male; Naloxone; Norepinephrine; Physical Exertion; Prolactin; Renin | 1984 |
[Neurophysiological and neuropharmacological studies on (possible) mechanisms of peripheral stimulation analgesia (author's transl)].
Topics: Acupuncture Therapy; Afferent Pathways; Animals; Cats; Electric Stimulation; Enkephalins; Hot Temperature; Humans; Naloxone; Nociceptors; Pain | 1980 |
In vivo and in vitro epileptogenic effects of the enkephalinergic system.
Topics: Animals; Convulsants; Electroencephalography; Enkephalins; Epilepsy; Hippocampus; Naloxone; Narcotics; Neprilysin; Rabbits; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Enkephalins in hematopoiesis.
Topics: Animals; Antibody Formation; Disease Models, Animal; Enkephalins; Hematopoiesis; Hematopoietic System; Immune System; In Vitro Techniques; Mice; Naloxone; Narcotic Antagonists; Neprilysin; Neuropeptides; Opioid Peptides | 1997 |
[Development of physical dependence on nicotine and endogenous opioid system--participation of α7 nicotinic acetylcholine receptor].
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Brain; Dynorphins; Endorphins; Enkephalins; Humans; Hypothalamo-Hypophyseal System; Mice; Naloxone; Narcotic Antagonists; Nicotine; Nociception; Opioid Peptides; Pituitary-Adrenal System; Tobacco Use Disorder | 2014 |
10 trial(s) available for enkephalin, leucine and naloxone
| Article | Year |
|---|---|
Effect of an opiate antagonist on movement disorders.
Topics: Adult; Aged; Clinical Trials as Topic; Enkephalins; Humans; Huntington Disease; Middle Aged; Naloxone; Naltrexone; Parkinson Disease | 1978 |
Is there some indication from behavioral effects of endorphins for their involvement in psychiatric disorders?
Topics: Animals; Behavior, Animal; Catatonia; Clinical Trials as Topic; Double-Blind Method; Endorphins; Enkephalins; Humans; Male; Naloxone; Rats; Schizophrenia; Vocalization, Animal | 1978 |
Involvement of enkephalins and other endogenous opioids in the regulation of esophageal motility.
Topics: Adult; Double-Blind Method; Endorphins; Enkephalins; Esophagogastric Junction; Esophagus; Gastrointestinal Motility; Humans; Male; Naloxone; Receptors, Opioid | 1987 |
Inhibition of vasopressin secretion by a met-enkephalin (FK 33-824) in humans.
Topics: Adult; Body Water; Clinical Trials as Topic; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Kidney; Lypressin; Male; Middle Aged; Naloxone; Prolactin; Receptors, Opioid; Vasopressins | 1980 |
Enkephalin, morphine, and naloxone in tardive dyskinesia.
Topics: Aged; Clinical Trials as Topic; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Double-Blind Method; Dyskinesia, Drug-Induced; Endorphins; Enkephalins; Female; Humans; Male; Middle Aged; Morphine; Naloxone; Parkinson Disease, Secondary | 1980 |
The opioid control of LH and FSH release: effects of a met-enkephalin analogue and naloxone.
Topics: Adolescent; Adult; Aged; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Female; Follicle Stimulating Hormone; Hormones; Humans; Luteinizing Hormone; Male; Menopause; Middle Aged; Naloxone | 1981 |
Enkephalin inhibits relaxation of the lower oesophageal sphincter.
Topics: D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalins; Esophagogastric Junction; Hormones; Humans; Naloxone; Pressure | 1982 |
Stimulatory effects of the synthetic enkephalin analogue FK 33-824 on colonic motor activity antagonized by naloxone.
Topics: Adult; Drug Antagonism; Endorphins; Enkephalins; Gastrointestinal Motility; Humans; Male; Naloxone; Respiration | 1981 |
[Basal secretion of endogenous opioids after intravenous naloxone].
Topics: beta-Endorphin; Enkephalin, Leucine; Humans; Male; Naloxone | 1994 |
Influence of opioids in hypothalamic nuclei on cold thermogenesis of lean and obese LA/N-cp rats.
Topics: Animals; Cold Temperature; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity; Opioid Peptides; Oxygen Consumption; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Stress, Physiological; Thermogenesis | 1994 |
1495 other study(ies) available for enkephalin, leucine and naloxone
| Article | Year |
|---|---|
Design, synthesis, and binding characteristics of an opiate receptor mimetic peptide.
Topics: Binding, Competitive; Chromatography, Gel; Circular Dichroism; Dialysis; Enkephalin, Leucine; Models, Molecular; Protein Conformation; Receptors, Opioid; Spectrophotometry, Ultraviolet; Thermodynamics | 1984 |
Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier.
Topics: Aged; Animals; Anion Transport Proteins; Biological Transport; Blood-Brain Barrier; Carrier Proteins; Enkephalin, D-Penicillamine (2,5)-; Humans; Male; Molecular Weight; Oligopeptides; Opioid Peptides; Rats | 2000 |
Structure-activity relationships of dynorphin a analogues modified in the address sequence.
Topics: Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Oligopeptides; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2003 |
Endogenous opiates-a progress report.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics, Opioid; Animals; Endorphins; Enkephalins; Humans; Naloxone; Oligopeptides; Pain; Peptides; Pituitary Gland; Prostaglandins; Receptors, Opioid | 1977 |
In vitro pharmacology of the opioid peptides, enkephalins and endorphins.
Topics: Animals; beta-Lipotropin; Brain; Depression, Chemical; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Neurotransmitter Agents; Oligopeptides; Peptide Fragments; Peptides; Synaptic Transmission; Time Factors; Vas Deferens | 1977 |
Pharmacotherapy II: narcotic and narcotic-antagonists analgesics.
Topics: Amines; Analgesics; Analgesics, Opioid; Binding Sites; Brain; Brain Chemistry; Codeine; Drug Tolerance; Enkephalins; Humans; Meperidine; Morphine; Naloxone; Narcotic Antagonists; Opium; Pain; Pentazocine; Receptors, Opioid; Sodium; Substance-Related Disorders | 1978 |
Inhibition of pancreatic secretion by enkephalin and morphine in dogs.
Topics: Animals; Bicarbonates; Cholecystokinin; Chronic Disease; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Duodenum; Endorphins; Enkephalins; Hydrogen-Ion Concentration; Morphine; Naloxone; Pancreas; Peptides; Proteins; Receptors, Opioid; Secretin | 1978 |
The relationship between enkephalin degradation and opiate receptor occupancy.
Topics: Aminopeptidases; Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Hydrogen-Ion Concentration; Kinetics; Membranes; Morphine; Naloxone; Puromycin; Rats; Receptors, Opioid | 1978 |
Opiate analgesics: the effect of agonist-antagonist character on prolactin secretion.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cyclazocine; Enkephalins; Male; Morphine; Naloxone; Narcotic Antagonists; Prolactin; Rats | 1978 |
Some considerations regarding the characterization and interpretation of neuropeptide-induced behavioral changes.
Topics: Animals; Behavior, Animal; Benzimidazoles; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Haloperidol; Humans; Injections, Intravenous; Injections, Intraventricular; Methadone; Mice; Morphine; Motor Activity; Naloxone; Peptides; Rats; Time Factors | 1978 |
Comparison of opiate- and opioid-peptide-induced immobility.
Topics: Amygdala; Animals; Benzimidazoles; Brain; Caudate Nucleus; Endorphins; Enkephalins; Globus Pallidus; Injections; Injections, Intraventricular; Injections, Subcutaneous; Male; Methadone; Morphine; Motor Activity; Naloxone; Narcotics; Rats | 1979 |
Are there opiate receptors in the invertebrates?
Topics: Animals; Central Nervous System; Dopamine; Enkephalins; Helix, Snails; Homovanillic Acid; Naloxone; Receptors, Opioid | 1979 |
Brain endorphins: possible role in reward and memory formation.
Topics: Animals; Avoidance Learning; Brain; Electric Stimulation; Endorphins; Enkephalins; Globus Pallidus; Memory; Naloxone; Neurotransmitter Agents; Rats; Receptors, Opioid; Reward; Self Stimulation | 1979 |
Enkephalins: the search for a functional role.
Topics: Bipolar Disorder; Endorphins; Enkephalins; Humans; Naloxone; Nociceptors; Pain; Schizophrenia | 1978 |
The effects of local micro injections of opiates and enkephalins into the forebrain on the electrocorticogram of the rat.
Topics: Animals; Brain; Codeine; Electroencephalography; Endorphins; Enkephalins; Etorphine; Male; Morphinans; Morphine; Naloxone; Rats; Receptors, Dopamine; Thebaine | 1978 |
Sensitivity to enkephalin as a cause of non-insulin dependent diabetes.
Topics: Alcoholic Beverages; Chlorpropamide; Diabetes Mellitus; Drug Antagonism; Endorphins; Enkephalins; Face; Hormones; Humans; Hypersensitivity; Naloxone; Skin Temperature | 1979 |
Effects of Met-enkephalin on body temperature of normal and morphine-tolerant rats.
Topics: Animals; Body Temperature; Drug Tolerance; Endorphins; Enkephalins; Injections, Intraventricular; Male; Morphine; Naloxone; Rats; Time Factors | 1978 |
TSH release-inhibiting activity of leucine-enkephalin.
Topics: Animals; Depression, Chemical; Endorphins; Enkephalins; Male; Naloxone; Pituitary Gland; Rats; Thyrotropin; Thyrotropin-Releasing Hormone | 1979 |
Comparison of tolerance development and dependence capacities of morphine, beta-endorphin, and [D-Met2, Pro5]-enkephalinamide.
Topics: Analgesia; Animals; Drug Tolerance; Endorphins; Enkephalins; Humans; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Rats; Substance-Related Disorders; Time Factors | 1979 |
Enkephalin-induced myoclonic twitches blocked by ergometrine and potentiated by haloperidol.
Topics: Animals; Drug Synergism; Endorphins; Enkephalins; Ergonovine; Female; Haloperidol; Male; Myoclonus; Naloxone; Rats; Time Factors | 1979 |
Enkephalin may mediate euphoria and drive-reduction reward.
Topics: Animals; Brain; Ditiocarb; Drive; Enkephalins; Euphoria; Female; Injections, Intraventricular; Morphine; Naloxone; Oligopeptides; Rats; Self Administration; Self Stimulation; Structure-Activity Relationship | 1977 |
Behavioural dissociation of the enkephalinergic systems of nucleus accumbens and nucleus caudatus.
Topics: Animals; Brain; Caudate Nucleus; Enkephalins; Globus Pallidus; Male; Morphine; Naloxone; Naltrexone; Olfactory Bulb; Oligopeptides; Rats; Receptors, Opioid; Stereotaxic Techniques | 1977 |
Endogenous opioid peptides: multiple agonists and receptors.
Topics: Animals; Benzomorphans; Brain; Endorphins; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Narcotic Antagonists; Narcotics; Oligopeptides; Peptides; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1977 |
A synthetic enkephalin analogue with prolonged parenteral and oral analgesic activity.
Topics: Administration, Oral; Analgesics; Animals; Enkephalins; Haplorhini; In Vitro Techniques; Injections; Mice; Morphine; Naloxone; Oligopeptides; Rats; Receptors, Opioid | 1977 |
Opioid peptides and opiates differ in receptor selectivity.
Topics: Animals; Brain; Dextrorphan; Endorphins; Enkephalins; Isomerism; Levorphanol; Methadone; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1977 |
The agonist and antagonist properties of N-allylenkephalins.
Topics: Allyl Compounds; Animals; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Receptors, Opioid; Tachyphylaxis | 1977 |
Hormone--receptor interactions: [4-carboranylalanine, 5-leucine]-enkephalin as a structural probe for the opiate receptor.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Kinetics; Male; Naloxone; Rats; Receptors, Opioid; Structure-Activity Relationship | 1977 |
A morphine-like factor in mammalian brain: analgesic activity in rats.
Topics: Analgesics; Animals; Brain; Cattle; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Motor Activity; Naloxone; Rats; Receptors, Opioid; Reticular Formation | 1977 |
Different receptors for somatostatin and opioids in neuroblastoma X glioma hybrid cells.
Topics: Animals; Binding, Competitive; Cyclic AMP; Enkephalins; Etorphine; Glioma; Hybrid Cells; Naloxone; Neuroblastoma; Neurons; Prostaglandins E; Rats; Receptors, Cell Surface; Receptors, Opioid; Somatostatin | 1977 |
A comparative study of the effect of methionine enkephalin upon the stereospecific binding of an opiate agonist and an antagonist in mice and rats.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Endorphins; Enkephalins; Mice; Morphine Derivatives; Naloxone; Rats; Receptors, Opioid | 1977 |
Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.
Topics: Animals; Binding, Competitive; Brain Chemistry; Cattle; Cell Line; Cell Membrane; Enkephalins; Etorphine; Humans; In Vitro Techniques; Morphine; Naloxone; Narcotics; Radioimmunoassay; Receptors, Opioid | 1977 |
Biochemical and physiological correlates of hypothalamic peptides. The new endocrinology of the neuron.
Topics: Animals; Behavior, Animal; beta-Lipotropin; Endorphins; Enkephalins; Fluorescent Antibody Technique; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Hypothalamus; Naloxone; Neural Conduction; Neural Inhibition; Neurons; Neurosecretion; Rats; Receptors, Opioid; Somatostatin; Thyrotropin-Releasing Hormone | 1978 |
Dual actions of substance P on nociception: possible role of endogenous opioids.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Mice; Naloxone; Nociceptors; Receptors, Opioid; Structure-Activity Relationship; Substance P | 1978 |
Opiate peptide modulation of amino acid responses suggests novel form of neuronal communication.
Topics: Cells, Cultured; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Glutamates; Iontophoresis; Naloxone; Neurons; Spinal Cord; Synapses; Synaptic Transmission | 1978 |
The opiate receptor binding interactions of 3H-methionine enkephalin, an opioid peptide.
Topics: Animals; Binding, Competitive; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Morphine Derivatives; Naloxone; Rats; Receptors, Opioid; Subcellular Fractions; Tissue Distribution | 1978 |
Different brain areas mediate the analgesic and epileptic properties of enkephalin.
Topics: Analgesia; Animals; Brain; Cerebral Aqueduct; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Naloxone; Rats; Receptors, Opioid; Seizures; Thalamic Nuclei | 1978 |
Stimulation of dopamine synthesis in caudate nucleus by intrastriatal enkephalins and antagonism by naloxone.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Dopamine; Endorphins; Enkephalins; Homovanillic Acid; Kainic Acid; Male; Naloxone; Rats; Receptors, Dopamine; Receptors, Opioid | 1978 |
Radioimmunoassay of enkephalins: levels of methionine- and leucine-enkephalin in morphine-dependent and kainic acid-lesioned rat brains.
Topics: Animals; Antibody Specificity; Brain Chemistry; Endorphins; Enkephalins; Humans; Kainic Acid; Male; Microwaves; Morphine Dependence; Naloxone; Pyrrolidines; Radioimmunoassay; Rats; Receptors, Opioid | 1978 |
Epileptic properties of leucine- and methionine-enkephalin: comparison with morphine and reversibility by naloxone.
Topics: Animals; Dose-Response Relationship, Drug; Electroencephalography; Endorphins; Enkephalins; Injections, Intraventricular; Leucine; Male; Methionine; Morphine; Naloxone; Rats; Receptors, Opioid; Seizures | 1978 |
In vivo comparison of the receptor populations acted upon in the spinal cord by morphine and pentapeptides in the production of analgesia.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Morphine; Naloxone; Nociceptors; Rats; Receptors, Opioid; Spinal Cord | 1978 |
Enkephalins, opiate receptors, and general anesthesia.
Topics: Anesthesia, General; Endorphins; Enkephalins; Humans; Naloxone; Receptors, Opioid | 1978 |
Opiate binding to membrane preparations of neuroblastoma x glioma hybrid cells NG108-15: effects of ions and nucleotides.
Topics: Cell Membrane; Cells, Cultured; Enkephalins; Etorphine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Magnesium; Manganese; Naloxone; Neuroblastoma; Nucleotides; Receptors, Opioid; Sodium | 1978 |
Methionine-enkephalin stimulates gastric secretion and gastric mucosal blood flow.
Topics: Animals; Dogs; Endorphins; Enkephalins; Female; Gastric Mucosa; Histamine; Male; Morphine; Naloxone; Pepsin A; Receptors, Opioid; Regional Blood Flow; Stimulation, Chemical | 1978 |
[Enkephalins and endorphins--a new class of biogenic physiologically active substances].
Topics: Analgesics; Animals; beta-Lipotropin; Brain; Catecholamines; Chemical Phenomena; Chemistry; Cyclic AMP; Drug Tolerance; Endorphins; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Mice; Morphine; Morphine Dependence; Naloxone; Rats; Receptors, Opioid | 1978 |
Effect of opioid peptides on L-noradrenaline-stimulated cyclic AMP formation in homogenates of rat cerebral cortex and hypothalamus.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Hypothalamus; Male; Morphine; Naloxone; Norepinephrine; Rats; Sodium | 1978 |
Effects of opiates and methionine-enkephalin on pontine and bulbar respiratory neurones of the cat.
Topics: Action Potentials; Animals; Cats; Cerebellum; Dextrorphan; Endorphins; Enkephalins; Glutamates; Levorphanol; Morphinans; Morphine; Naloxone; Neurons; Phrenic Nerve; Pons; Receptors, Opioid; Respiration; Respiratory Center | 1978 |
Electrophysiological effects of enkephalin analogs in rat cortex.
Topics: Action Potentials; Animals; Cerebral Cortex; Cyclic AMP; Endorphins; Enkephalins; Evoked Potentials; Female; Male; Naloxone; Rats; Structure-Activity Relationship | 1978 |
A comparison of the analgesic and behavioral effects of [D-Ala2] Met-enkepha-linamide and morphine in the mesencephalic reticular formation of rats.
Topics: Analgesia; Animals; Behavior, Animal; Brain Mapping; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Locomotion; Male; Morphine; Naloxone; Rats; Receptors, Opioid; Reticular Formation | 1978 |
Primary afferent depolarisation of tooth pulp afferents is not affected by naloxone.
Topics: Action Potentials; Afferent Pathways; Animals; Brain Stem; Cats; Conditioning, Psychological; Cuspid; Dental Pulp; Enkephalins; Naloxone; Pain; Receptors, Opioid | 1978 |
Enkephalins and nigrostriatal function.
Topics: Animals; Apomorphine; Behavior, Animal; Dextroamphetamine; Endorphins; Enkephalins; Hydroxydopamines; Levodopa; Male; Naloxone; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Rats; Receptors, Opioid; Reserpine; Substantia Nigra | 1978 |
Interaction of morphine, etorphine and enkephalins with dopamine-stimulated adenylate cyclase of monkey amygdala.
Topics: Adenylyl Cyclases; Amygdala; Animals; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Etorphine; Freezing; Haplorhini; Macaca mulatta; Morphinans; Morphine; Naloxone; Receptors, Opioid; Stimulation, Chemical | 1979 |
Manipulation of opiate activity in the amygdala alters memory processes.
Topics: Amygdala; Animals; Basal Ganglia; Dextrorphan; Enkephalins; Levorphanol; Male; Memory; Naloxone; Rats; Receptors, Opioid | 1978 |
Studies on the interaction of endorphins, substance P. and endogenous somatostatin in growth hormone and prolactin release in rats.
Topics: Animals; Brain; Endorphins; Enkephalins; Growth Hormone; Hypothalamo-Hypophyseal System; Injections, Intraventricular; Male; Morphine; Naloxone; Prolactin; Rats; Receptors, Opioid; Somatostatin; Substance P | 1978 |
ACh, substance P and met-enkephalin in the locus coeruleus: pharmacological evidence for independent sites of action.
Topics: Acetylcholine; Animals; Baclofen; Endorphins; Enkephalins; Locus Coeruleus; Male; Naloxone; Parasympatholytics; Parasympathomimetics; Rats; Receptors, Cholinergic; Substance P; Synaptic Transmission | 1979 |
Specific versus non-specific actions of opioids on hippocampal neurones in the rat brain.
Topics: Action Potentials; Animals; Dextrorphan; Drug Tolerance; Endorphins; Enkephalins; Evoked Potentials; Glutamates; Hippocampus; Levorphanol; Male; Morphine; Naloxone; Neural Inhibition; Neurons; Rats; Receptors, Opioid; Synaptic Transmission | 1979 |
On the mechanism and site of action of enkephalin on single myenteric neurons.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Guinea Pigs; Iontophoresis; Male; Membrane Potentials; Myenteric Plexus; Naloxone; Neurons; Receptors, Opioid | 1979 |
Brain endorphins: possible mediators of pleasure and reward.
Topics: Animals; Brain; Ditiocarb; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Injections, Intraventricular; Memory; Naloxone; Rats; Reinforcement, Psychology; Reward; Self Stimulation; Substance P | 1978 |
Endogenous opioids may mediate post-ictal behavioral depression in amygdaloid-kindled rats.
Topics: Amygdala; Animals; Behavior, Animal; Electric Stimulation; Electroencephalography; Endorphins; Enkephalins; Evoked Potentials; Morphine; Naloxone; Rats; Receptors, Opioid; Seizures | 1979 |
Cerebellar opiate receptors in lagomorphs. Demonstration, characterization and regional distribution.
Topics: Animals; Brain Mapping; Cerebellar Cortex; Cerebellum; Cricetinae; Dextrorphan; Enkephalins; Etorphine; Female; Levorphanol; Male; Mice; Morphine; Naloxone; Rabbits; Rats; Receptors, Opioid; Species Specificity | 1979 |
Excitation by morphine and enkephalin of single neurons of nucleus reticularis paragigantocellularis in the rat: a probable mechanism of analgesic action of opioids.
Topics: Animals; Bradykinin; Endorphins; Enkephalins; Evoked Potentials; Male; Medulla Oblongata; Morphine; Naloxone; Neural Inhibition; Neural Pathways; Neurons; Nociceptors; Rats; Receptors, Opioid; Reticular Formation | 1979 |
The effects of methionine- and leucine-enkephalin on spinal neurones of the cat.
Topics: Animals; Cats; Endorphins; Enkephalins; Female; Ganglia, Spinal; Glutamates; Hindlimb; Male; Mechanoreceptors; Membrane Potentials; Motor Neurons; Naloxone; Neurons; Receptors, Opioid; Spinal Cord | 1979 |
Electroencephalographic and behavioral tolerance to and cross-tolerance between D-Ala2-methionine-enkephalinamide and morphine in the rat.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Electroencephalography; Endorphins; Enkephalins; Female; Humans; Morphine; Morphine Dependence; Naloxone; Rats; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1979 |
Endogenous opiates block dopamine inhibition of prolactin secretion in vitro.
Topics: Animals; Dopamine Antagonists; Dose-Response Relationship, Drug; Endorphins; Enkephalins; In Vitro Techniques; Male; Morphine; Naloxone; Pituitary Gland; Prolactin; Rats; Receptors, Drug; Receptors, Opioid | 1979 |
[Effect of leucine-enkephalin on the interneuronal transmission of excitation].
Topics: Animals; Cats; Central Nervous System; Drug Interactions; Electric Stimulation; Endorphins; Enkephalins; Evoked Potentials; Female; Leucine; Male; Methysergide; Naloxone; Synaptic Transmission | 1979 |
Effects of opiate-like peptides, morphine, and naloxone in the photosensitive baboon, Papio papio.
Topics: Animals; Blood Pressure; Cerebral Cortex; Electroencephalography; Endorphins; Enkephalins; Evoked Potentials; Haplorhini; Injections, Intramuscular; Injections, Intraventricular; Morphine; Myoclonus; Naloxone; Papio; Photic Stimulation; Receptors, Opioid; Respiration; Seizures; Thalamic Nuclei | 1979 |
Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes.
Topics: Binding Sites; Dextromoramide; Endorphins; Enkephalins; Humans; Kinetics; Methionine; Naloxone; Receptors, Drug; Receptors, Opioid; Rosette Formation; Stereoisomerism; T-Lymphocytes | 1979 |
Evidence for morphine and morphine-like alkaloid responses resistant to naloxone blockade in the rat vas deferens.
Topics: Animals; Drug Tolerance; Electric Stimulation; Enkephalins; In Vitro Techniques; Leucine; Male; Morphine; Morphine Derivatives; Muscle Contraction; Naloxone; Narcotics; Placebos; Rats; Receptors, Opioid; Vas Deferens | 1979 |
Opioid peptides and protein phosphorylation.
Topics: Adenylyl Cyclases; Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; beta-Lipotropin; Brain; Endorphins; Enkephalins; Naloxone; Nerve Tissue Proteins; Neurons; Phosphoproteins; Phosphorylation; Receptors, Opioid; Synaptic Membranes; Synaptosomes | 1979 |
Methionine enkephalin and morphine alter monoamine and cyclic nucleotide levels in the cerebral ganglia of the freshwater bivalve Anodonta cygnea.
Topics: Animals; Cyclic AMP; Cyclic GMP; Dopamine; Endorphins; Enkephalins; Ganglia; Mollusca; Morphine; Naloxone | 1979 |
Selective and non-selective inhibition by enkephalins and noradrenaline of nociceptive response of lamina V type neurons in the spinal dorsal horn of the rabbit.
Topics: Animals; Endorphins; Enkephalins; Evoked Potentials; Ganglia, Spinal; Male; Naloxone; Neural Inhibition; Neurons; Nociceptors; Norepinephrine; Rabbits; Receptors, Opioid | 1979 |
II - Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists.
Topics: Analgesics; Animals; Barium; Bucladesine; Endorphins; Enkephalins; Hyperalgesia; Hyperesthesia; Ionophores; Isoproterenol; Lidocaine; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Nociceptors; Pentazocine; Prostaglandins E; Rats | 1979 |
Effect of melatonin and methionine-enkephalin on surfacing responses in goldfish.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Goldfish; Melatonin; Motor Activity; Naloxone; Nociceptors; Peptides; Receptors, Opioid | 1979 |
Biosynthesis of the enkephalins in the myenteric plexus of the guinea pig ileum: further analysis of the interaction of the enkephalins and their analogues with the opiate receptors.
Topics: Animals; Binding Sites; Brain; Cycloheximide; Dihydromorphine; Endorphins; Enkephalins; Guinea Pigs; Ileum; Myenteric Plexus; Naloxone; Receptors, Opioid; Trypsin | 1979 |
Dopamine-mediated behavior produced by the enkephalin analogue FK 33-824.
Topics: Animals; Apomorphine; Chlorpromazine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Haloperidol; Humans; Male; Naloxone; Rats; Receptors, Dopamine; Receptors, Opioid; Stereotyped Behavior | 1979 |
Synthesis of opiate peptides by a clonal pituitary tumor cell line.
Topics: Adenylyl Cyclases; Animals; Biological Assay; Cell Line; Clone Cells; Electric Stimulation; Endorphins; Enkephalins; Enzyme Activation; Guinea Pigs; Ileum; Kinetics; Naloxone; Oligopeptides; Peptide Biosynthesis; Peptide Hydrolases; Pituitary Neoplasms; Prostaglandins E | 1977 |
Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.
Topics: Animals; Brain; Brain Stem; Endorphins; Enkephalins; Hippocampus; Naloxone; Neurons; Oligopeptides; Organ Specificity; Peptides; Rats | 1977 |
beta-Endorphin induces nonconvulsive limbic seizures.
Topics: Animals; Behavior, Animal; Electroencephalography; Endorphins; Enkephalins; Injections, Intraventricular; Limbic System; Morphine; Motor Activity; Naloxone; Rats; Seizures | 1978 |
Met-enkephalin inhibits in vitro dopamine-induced LHRH release from mediobasal hypothalamus of male rats.
Topics: Animals; Dopamine Antagonists; Endorphins; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus; Male; Median Eminence; Naloxone; Nerve Endings; Rats | 1978 |
In vitro effects of a synethetic enkephalin analogue (D-Met2,Pro5)-enkephalinamide on the hypothalamus-pituitary--testis function in rats.
Topics: Animals; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus; Hypothalamus, Middle; In Vitro Techniques; Leydig Cells; Male; Naloxone; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains | 1979 |
[Endorphins: a key to understanding pain, addiction and mental disorders?].
Topics: Endorphins; Enkephalins; Humans; Mental Disorders; Morphine Dependence; Naloxone; Pain; Substance-Related Disorders | 1979 |
Neurotensin: antinocisponsive action in rodents.
Topics: Analgesics; Animals; Anticonvulsants; Body Temperature; Enkephalins; Hot Temperature; Mice; Motor Activity; Naloxone; Neurotensin; Postural Balance; Rats; Reaction Time; Species Specificity; Time Factors | 1979 |
Effects of endorphins on single myenteric neurons.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Evoked Potentials; Guinea Pigs; Male; Myenteric Plexus; Naloxone; Neural Inhibition; Neurons | 1979 |
Acute tolerance to the excitatory effect of enkephalin microinjections into hippocampus.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Electroencephalography; Endorphins; Enkephalins; Hippocampus; Male; Microinjections; Naloxone; Rats | 1979 |
Stimulant effects of enkephalin microinjection into the dopaminergic A10 area.
Topics: Animals; Behavior, Animal; Dopamine; Endorphins; Enkephalins; Male; Microinjections; Motor Activity; Naloxone; Rats; Stimulation, Chemical; Tegmentum Mesencephali | 1979 |
Induction of copulatory behavior in sexually inactive rats by naloxine.
Topics: Animals; Copulation; Endorphins; Enkephalins; Feeding Behavior; Male; Motor Activity; Naloxone; Rats | 1979 |
The effect of enkephalins on the intramural inhibitory non-adrenergic nerve responses of smooth muscle.
Topics: Animals; Colon; Endorphins; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Neural Inhibition; Stomach | 1979 |
Effects of beta-endorphin and D-alanine2 enkephalinamide on urine production and urinary electrolytes in the rat.
Topics: Animals; Diuresis; Electrolytes; Endorphins; Enkephalins; Female; Injections, Intraventricular; Male; Naloxone; Rats | 1979 |
Presynaptic effects of morphine and methionine-enkephalin in feline spinal cord.
Topics: Action Potentials; Animals; Bradykinin; Cats; Electric Stimulation; Endorphins; Enkephalins; Female; gamma-Aminobutyric Acid; Male; Morphine; Naloxone; Spinal Cord; Synapses; Time Factors | 1979 |
Lack of effect by substance P at sites in the substantia gelatinosa where Met-enkephalin reduces the transmission of nociceptive impulses.
Topics: Action Potentials; Animals; Cats; Endorphins; Enkephalins; Hair; Hot Temperature; Naloxone; Nociceptors; Skin; Skin Physiological Phenomena; Spinal Cord; Substance P; Substantia Gelatinosa | 1979 |
K-stimulated release of leu- and met-enkephalin from rat striatal slices: lack of effect of morphine and naloxone.
Topics: Animals; Calcium; Corpus Striatum; Endorphins; Enkephalins; In Vitro Techniques; Leucine; Magnesium; Male; Methionine; Morphine; Naloxone; Potassium; Radioimmunoassay; Rats | 1979 |
Comparison of binding of [3H]-methionine-enkephalin, [3H]-naltrexone and [3H]-dihydromorphine in the mouse vas deferens and the myenteric plexus and brain of the ginea pig.
Topics: Animals; Brain; Dihydromorphine; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine Derivatives; Myenteric Plexus; Naloxone; Naltrexone; Organ Specificity; Stereoisomerism; Vas Deferens | 1979 |
Enkephalins increase dopamine levels in the CNS of a marine mollusc.
Topics: Animals; Bivalvia; Central Nervous System; Dopamine; Endorphins; Enkephalins; Naloxone; Serotonin; Stimulation, Chemical; Time Factors | 1979 |
Effects of presynaptic modulators on Ca2+-induced noradrenaline release from central noradrenergic neurons. Noradrenaline and enkephalin inhibit release by decreasing depolarization-induced Ca2+ influx.
Topics: Animals; Calcium; Central Nervous System; Drug Interactions; Endorphins; Enkephalins; In Vitro Techniques; Male; Naloxone; Neurons; Norepinephrine; Phentolamine; Potassium; Rats | 1979 |
Studies on the hyperthermic response of beta-endorphin in mice.
Topics: Analgesics; Animals; Aspirin; Body Temperature; Cations, Divalent; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalins; Environment; Indomethacin; Mice; Mice, Inbred ICR; Morphine; Naloxone; Time Factors | 1979 |
Naloxone-precipitated jumping in mice pretreated with acute injections of opioids.
Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Enkephalins; Heroin; Male; Methadone; Methadyl Acetate; Mice; Morphine; Naloxone; Narcotics; Pentazocine | 1979 |
Effect of Met-enkephalin and (D-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain.
Topics: Adenylyl Cyclases; Animals; Brain; Endorphins; Enkephalins; Methionine; Naloxone; Rats | 1979 |
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine | 1979 |
Selective effects of enkephalin on electrical activity of the in vitro hippocampal slice.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; Evoked Potentials; Hippocampus; Naloxone; Rats; Synapses | 1979 |
A further characterization of the differential effects of leucine enkephalin, methionine enkephalin and their analogs on morphine-induced analgesia.
Topics: Anesthesia; Animals; Behavior, Animal; Drug Synergism; Endorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Structure-Activity Relationship; Time Factors | 1979 |
Naloxone-reversible effect of opioids on pinocytosis in Amoeba proteus.
Topics: Amoeba; Animals; Calcium; Cations; Endorphins; Enkephalins; Morphine; Naloxone; Pinocytosis; Sodium | 1979 |
Inhibition of PGE1 induced intestinal secretion by the synthetic enkephalin analogue FK 33-824.
Topics: Animals; Endorphins; Enkephalins; Female; Half-Life; Intestinal Mucosa; Intestines; Morphine; Naloxone; Prostaglandins E; Rats | 1979 |
Facilitation of self-stimulation behavior following intracerebral microinjections of opioids into the ventral tegmental area.
Topics: Animals; Brain; Enkephalins; Hypothalamus; Injections, Intraventricular; Male; Microinjections; Morphine; Naloxone; Narcotics; Rats; Self Stimulation; Time Factors | 1979 |
Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons.
Topics: Animals; Castration; Dopamine; Endorphins; Enkephalins; Female; Morphine; Naloxone; Pituitary Gland; Rats | 1979 |
Comparative thermoregulatory effects of opioids in the rat and the Mongolian gerbil.
Topics: Animals; Body Temperature Regulation; Endorphins; Enkephalins; Female; Gerbillinae; Male; Morphine; Naloxone; Narcotics; Rats; Species Specificity | 1979 |
Stimulation produced analgesia and endogenous opiate-like peptides [proceedings].
Topics: Analgesics; Animals; Electric Stimulation; Endorphins; Enkephalins; Mesencephalon; Naloxone; Pain; Rats | 1979 |
Endorphin-induced hyperthermia: characterization of the exogenously and endogenously induced effects.
Topics: Animals; Body Temperature; Cold Temperature; Depression, Chemical; Drug Tolerance; Endorphins; Enkephalins; Injections, Intraventricular; Male; Morphine; Naloxone; Rats; Stress, Physiological | 1979 |
III - Prostaglandin hyperalgesia: relevance of the peripheral effect for the analgesic action of opioid-antagonists.
Topics: Analgesics; Animals; Carrageenan; Enkephalins; Hyperalgesia; Hyperesthesia; Injections, Intraperitoneal; Injections, Intraventricular; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Nociceptors; Pentazocine; Prostaglandins E; Rats | 1979 |
Effects of enkephalin analogue and naloxone on cat spinal cord dorsal root potentials.
Topics: Animals; Cats; Endorphins; Enkephalins; Female; Male; Membrane Potentials; Naloxone; Spinal Nerve Roots; Time Factors | 1979 |
Possible non-narcotic component to action of opiate peptides on tonic immobility.
Topics: Animals; Animals, Newborn; Chickens; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorocarbons; Hormones; Motor Activity; Naloxone | 1979 |
Neuroanatomical focus for morphine and enkephalin-induced hypermotility.
Topics: Animals; Apomorphine; Dopamine; Drug Interactions; Enkephalins; Haloperidol; Humans; Hyperkinesis; Injections; Injections, Intraperitoneal; Male; Morphine; Naloxone; Olfactory Bulb; Oligopeptides; Rats; Stimulation, Chemical; Time Factors | 1977 |
C-fragment of lipotropin--an endogenous potent analgesic peptide.
Topics: Analgesics; Animals; beta-Lipotropin; Blood Glucose; Catalepsy; Cats; Endorphins; Enkephalins; Female; Humans; Male; Naloxone; Peptide Fragments; Peptides; Time Factors | 1977 |
Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli.
Topics: Animals; Circadian Rhythm; Endorphins; Enkephalins; Hot Temperature; Hyperalgesia; Hyperesthesia; Mice; Naloxone; Reaction Time | 1977 |
New in vivo evidence for narcotic agonistic property of leucine-enkephalin.
Topics: Animals; Behavior, Animal; Endorphins; Enkephalins; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotics; Substance Withdrawal Syndrome | 1978 |
The effect of beta-endorphin and met-enkephalin on striatin dopamine metabolism and catalepsy: comparison with morphine.
Topics: Animals; Catalepsy; Corpus Striatum; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Homovanillic Acid; Humans; Injections, Intraventricular; Male; Morphine; Naloxone; Phenylacetates; Rats | 1977 |
The influence of electro-acupuncture on naloxone-induced morphine withdrawal in mice: elevation of brain opiate-like activity.
Topics: Acupuncture Therapy; Animals; Brain Chemistry; Endorphins; Enkephalins; Female; Humans; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome | 1978 |
[D-Thr2, Thz5]-enkephalinamide: a potent analgesic by subcutaneous and oral administration.
Topics: Administration, Oral; Analgesics; Animals; Endorphins; Enkephalins; Humans; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Time Factors | 1978 |
In vivo interaction of morphine and endogenous opiate-like peptides.
Topics: Animals; Drug Interactions; Endorphins; Enkephalins; Humans; Male; Morphine; Naloxone; Radioimmunoassay; Rats; Stereotyped Behavior; Time Factors | 1978 |
Comparison of the analgesic effects of various opioid peptides by a newly devised intracisternal injection technique in conscious mice.
Topics: Animals; Cisterna Magna; Endorphins; Enkephalins; Injections, Spinal; Male; Mice; Morphine; Motor Activity; Naloxone | 1979 |
Enkephalins and dorsal horn neurones of the cat: effects on responses to noxious and innocuous skin stimuli.
Topics: Animals; Cats; Electric Stimulation; Endorphins; Enkephalins; gamma-Aminobutyric Acid; Glycine; Injections; Mechanoreceptors; Naloxone; Neurons; Skin Physiological Phenomena; Spinal Nerve Roots; Substantia Gelatinosa | 1977 |
Inhibitory effect of enkephalins on contractions of the guinea-pig ileum elicited by PGE1.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Prostaglandins E | 1977 |
Respiratory and cardiovascular effects of met-enkephalin applied to the ventral surface of the brain stem.
Topics: Animals; Blood Pressure; Brain Stem; Cats; Endorphins; Enkephalins; Heart Rate; Naloxone; Respiration; Tidal Volume; Time Factors | 1977 |
(3H) Opiate binding: anomalous properties in kidney and liver membranes.
Topics: Animals; Cattle; Enkephalins; Guinea Pigs; In Vitro Techniques; Kidney; Liver; Membranes; Naloxone; Narcotics; Rabbits; Rats; Species Specificity; Tissue Distribution | 1978 |
Release of vasopressin by enkephalin.
Topics: Animals; Endorphins; Enkephalins; Naloxone; Rats; Time Factors; Vasopressins | 1978 |
Opiate-like naloxone-reversible actions of somatostatin given intracerebrally.
Topics: Animals; Enkephalins; Injections, Intraventricular; Male; Naloxone; Narcotics; Rats; Reaction Time; Somatostatin; Time Factors | 1978 |
Cardiovascular effects of morphine and opioid peptides following intracisternal administration in chloralose-anesthetized rats.
Topics: Anesthesia; Animals; Chloralose; Endorphins; Enkephalins; Hemodynamics; Male; Morphine; Naloxone; Rats | 1978 |
Brain endorphins and the sense of well-being: a psychobiological hypothesis.
Topics: Animals; Brain; Brain Chemistry; Conditioning, Operant; Drug Tolerance; Emotions; Endorphins; Enkephalins; Memory; Naloxone; Rats; Self Administration; Self Stimulation; Time Factors | 1978 |
Stimulation of growth hormone and prolactin release by a potent enkephalin analog.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Growth Hormone; Male; Morphine; Naloxone; Prolactin; Rats; Somatostatin; Structure-Activity Relationship | 1978 |
Effects of morphine and two enzyme resistant enkephalins on schedule-controlled responding in the rat.
Topics: Animals; Conditioning, Operant; Endorphins; Enkephalins; Male; Morphine; Naloxone; Rats; Reinforcement Schedule; Time Factors | 1978 |
In vitro profile of some opioid pentapeptide analogues.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Vas Deferens | 1978 |
Effect of morphine, naloxone and an enkephalin analogue on plasma prolactin, growth hormone, insulin and thyroxine in goats [proceedings].
Topics: Animals; Endorphins; Enkephalins; Goats; Growth Hormone; Insulin; Morphine; Naloxone; Prolactin; Thyroxine | 1978 |
Synthesis of two enzyme resistant enkephalin analogs possessing enhanced analgesic activity.
Topics: Analgesics; Animals; Drug Tolerance; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Reaction Time; Time Factors | 1978 |
Naloxone does not antagonize general anesthesia in the rat.
Topics: Anesthesia, Inhalation; Animals; Dose-Response Relationship, Drug; Enkephalins; Halothane; Naloxone; Rats; Seizures; Spirometry | 1978 |
Behavioral activation by enkephalins in mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Mice; Motor Activity; Naloxone | 1978 |
Depressant actions of methionine-enkephalin and somatostatin in cat dorsal horn neurones activated by noxious stimuli.
Topics: Animals; Cats; Endorphins; Enkephalins; Evoked Potentials; Mechanoreceptors; Methionine; Naloxone; Neurons; Nociceptors; Skin; Somatostatin; Spinal Cord | 1978 |
Effects of endorphins on prolactin and growth hormone secretion in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalins; Growth Hormone; Male; Naloxone; Prolactin; Rats | 1978 |
Inhibition of copulatory behavior in male rats by D-Ala2-Met-enkephalinamide.
Topics: Animals; Copulation; Depression, Chemical; Dose-Response Relationship, Drug; Ejaculation; Endorphins; Enkephalins; Male; Motor Activity; Naloxone; Rats; Time Factors | 1978 |
Failure of (+)-naloxone to antagonise responses to opioid peptides.
Topics: Animals; Brain Stem; Drug Interactions; Endorphins; Enkephalins; gamma-Aminobutyric Acid; Male; Naloxone; Neurons; Rats | 1978 |
Effects of met5-enkephalin and naloxone on spontaneous seizures in the Mongolian gerbil.
Topics: Animals; Behavior, Animal; Electroencephalography; Endorphins; Enkephalins; Female; Gerbillinae; Male; Naloxone; Seizures | 1978 |
Brief communication. Generalization of [DAla2]-enkephalinamide but not of substance P to the morphine cue.
Topics: Animals; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Generalization, Stimulus; Injections, Intraperitoneal; Injections, Intraventricular; Male; Morphine; Naloxone; Rats; Substance P | 1978 |
3H-Leu5-enkephalin specific binding to synaptic membrane-comparison with 3H-dihydromorphine and 3H-naloxone.
Topics: Animals; Bacitracin; Dihydromorphine; Drug Interactions; Drug Stability; Endorphins; Enkephalins; In Vitro Techniques; Kinetics; Morphine Derivatives; Naloxone; Protein Binding; Rats; Synaptic Membranes; Temperature | 1978 |
Effects of methionine-enkephalin and morphine on spontaneous locomotor activity: antagonism by naloxone.
Topics: Animals; Endorphins; Enkephalins; Male; Mice; Morphine; Motor Activity; Naloxone; Time Factors | 1978 |
Effect of the administration of (d-Ala) 2methionine-enkephalin on the serotonin metabolism in rat brain.
Topics: Animals; Brain; Endorphins; Enkephalins; Hydroxyindoleacetic Acid; Male; Naloxone; Rats; Serotonin | 1978 |
Speculations on similarities between autism and opiate addiction.
Topics: Autistic Disorder; Endorphins; Enkephalins; Heroin Dependence; Humans; Morphine; Naloxone; Social Behavior | 1978 |
In vivo antagonism by naloxone of morphine, beta-endorphin and a synthetic enkephalin analog.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Rats; Reaction Time | 1978 |
Activity of VIP, somatostatin and other peptides in the mouse vas deferens assay.
Topics: Animals; Enkephalins; Gastrointestinal Hormones; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Peptides; Somatostatin; Vas Deferens; Vasoactive Intestinal Peptide | 1978 |
Substance P and opioid interaction on stimulated and non-stimulated guinea pig ileum.
Topics: Animals; Atropine; Drug Interactions; Electric Stimulation; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Substance P | 1978 |
[D-Alanine2]-methionine enkephalinamide binding to rat brain slices: differences from opiate alkaloid binding and reduction by chronic morphine treatment.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; In Vitro Techniques; Male; Morphinans; Morphine; Naloxone; Rats; Time Factors | 1978 |
Endogenous opiates and behavioral responses to environmental novelty.
Topics: Animals; Endorphins; Enkephalins; Exploratory Behavior; Male; Mice; Naloxone; Stimulation, Chemical | 1978 |
The accumulation of (3H) enkephalinamide (2-D-alanine-5-methioninamide) in rat brain tissues.
Topics: Animals; Biotransformation; Brain; Cerebral Cortex; Choroid Plexus; Endorphins; Enkephalins; Ethylmaleimide; Female; In Vitro Techniques; Naloxone; Rats; Time Factors | 1978 |
Emetic and hyperthermic effects of centrally injected methionine-enkephalin in cats.
Topics: Animals; Body Temperature; Cats; Enkephalins; Injections, Intraventricular; Morphine; Naloxone; Oligopeptides; Vomiting | 1977 |
Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum.
Topics: Animals; Binding, Competitive; Brain; Cations, Divalent; Cations, Monovalent; Dextrorphan; Enkephalins; In Vitro Techniques; Levorphanol; Male; Mitochondria; Naloxone; Oligopeptides; Rats | 1977 |
Morphine and enkephalin: analgesic and epileptic properties.
Topics: Action Potentials; Analgesia; Animals; Brain; Cerebral Aqueduct; Electroencephalography; Enkephalins; Injections, Intraventricular; Male; Morphine; Naloxone; Oligopeptides; Rats; Seizures | 1977 |
Leu-enkephalin-stimulated growth hormone and prolactin release in the rat: comparison with the effect of morphine.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Enkephalins; Female; Growth Hormone; Injections, Intraventricular; Male; Morphine; Naloxone; Oligopeptides; Prolactin; Rats | 1977 |
Iontophoresis of methionine-enkephalin in the locus coeruleus area.
Topics: Animals; Cerebral Ventricles; Enkephalins; Iontophoresis; Male; Membrane Potentials; Methionine; Naloxone; Neural Inhibition; Oligopeptides; Rats; Sodium Glutamate; Stimulation, Chemical | 1977 |
Comparison of the behavioral effects of beta-endorphin and enkephalin analogs.
Topics: Animals; Behavior, Animal; Endorphins; Enkephalins; Etorphine; Male; Mice; Morphine; Motor Activity; Naloxone; Oligopeptides; Peptides; Rats | 1977 |
Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Growth Hormone; Luteinizing Hormone; Male; Morphine; Naloxone; Oligopeptides; Prolactin; Rats; Thyrotropin | 1977 |
Monitoring the stereospecificity of morphine action in vivo and in vitro through brain membrane lipid fluidity.
Topics: Animals; Brain; Calorimetry, Differential Scanning; Dextrorphan; Enkephalins; Levorphanol; Male; Membrane Lipids; Mitochondria; Morphine; Naloxone; Rats; Structure-Activity Relationship | 1977 |
Enkephalin effects on release of brain acetylcholine.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Cerebral Cortex; Depression, Chemical; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Naloxone; Rats | 1977 |
Enkephalin analogues and naloxone modulate the release of growth hormone and prolactin--evidence for regulation by an endogenous opioid peptide in brain.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Female; Growth Hormone; Morphine; Naloxone; Prolactin; Rats; Structure-Activity Relationship | 1977 |
The direct and specific opiate-like effect of met5-enkephalin and analogues on the spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Naloxone; Rats; Spinal Cord; Time Factors | 1977 |
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics | 1992 |
Kappa-/mu-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Male; Models, Neurological; Naloxone; Naltrexone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 1992 |
Perinatal morphine exposure alters peptidergic development in the striatum.
Topics: Animals; Blotting, Northern; Body Weight; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Growth; Immunohistochemistry; In Situ Hybridization; Morphine; Naloxone; Naltrexone; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P | 1992 |
[The contractile activity of the lymphatic microvessels and the role of opioid peptides in its regulation].
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Lymphatic System; Male; Mesentery; Muscle Contraction; Naloxone; Rats | 1992 |
Opioid agonists binding and responses in SH-SY5Y cells.
Topics: Alprostadil; Analgesics; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP Phosphohydrolases; Humans; Meperidine; Morphinans; Naloxone; Narcotics; Oxymorphone; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1992 |
Location of enkephalinase and functional effects of [Leu5]enkephalin and inhibition of enkephalinase in the feline main pancreatic and bile duct sphincters.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Enkephalins; Naloxone; Neprilysin; Sphincter of Oddi; Tetrodotoxin | 1992 |
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil | 1992 |
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach | 1992 |
Role of spinal opioid receptors in the antinociceptive interactions between intrathecal morphine and bupivacaine.
Topics: Analgesics; Animals; Bupivacaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Leucine; Injections, Spinal; Male; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Selective impairment of neuroendocrine and hemodynamic responses to a mu-opioid peptide in aged rats.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Corticotropin-Releasing Hormone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Hemodynamics; Hormones; Naloxone; Norepinephrine; Prolactin; Rats; Rats, Inbred F344 | 1992 |
A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro.
Topics: Amino Acids; Analgesics; Animals; Benzofurans; Benzomorphans; Bicuculline; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Ligands; Locus Coeruleus; Membrane Potentials; Naloxone; Naltrexone; Picrotoxin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Opioid peptides reduce synaptic transmission in the nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Naloxone; Neurons; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synapses; Synaptic Transmission | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Met- and Leu-enkephalin modulate superoxide anion release from human polymorphonuclear cells.
Topics: Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Naloxone; Neutrophils; Respiratory Burst; Superoxides | 1992 |
Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Bradykinin; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Joints; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
Opioid-inhibited adenylyl cyclase in rat brain membranes: lack of correlation with high-affinity opioid receptor binding sites.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding Sites; Brain; Cell Membrane; Colforsin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine Triphosphate; Male; Naloxone; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sodium; Sodium Chloride; Sodium Fluoride | 1992 |
Antinociceptive mechanisms of [D-Arg2]-dermorphin tripeptide analogs.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Mice; Molecular Sequence Data; Naloxone; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu; Synaptosomes | 1992 |
Opioid receptor agonists and Ca2+ modulation in human B cell lines.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; B-Lymphocytes; Benzeneacetamides; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Humans; Naloxone; Pyrrolidines; Receptors, Opioid; Signal Transduction | 1992 |
Autoradiographic evidence of opioid binding sites in the thyroid gland.
Topics: Animals; Autoradiography; Dose-Response Relationship, Drug; Enkephalins; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reference Values; Thyroid Gland; Tritium | 1992 |
Thermodynamic analysis of the temperature dependence of the dissociation constant of naloxone at opioid delta receptors in the mouse isolated vas deferens.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Receptors, Opioid, delta; Temperature; Thermodynamics; Vas Deferens | 1992 |
Cloning of a delta opioid receptor by functional expression.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Blotting, Southern; Cell Line; Cyclic AMP; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Gene Expression; Humans; Kinetics; Models, Structural; Molecular Sequence Data; Naloxone; Narcotics; Protein Structure, Secondary; Receptors, Opioid, delta; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured | 1992 |
Influence of opioids on CSF vasopressin concentration in newborn pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analysis of Variance; Animals; Animals, Newborn; beta-Endorphin; Cerebral Arteries; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Naloxone; Pyrrolidines; Swine; Vasopressins | 1992 |
Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogs activate two mu opioid receptor subtypes that modulate antinociception and catalepsy in the rat.
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Anura; Binding, Competitive; Brain; Catalepsy; Cerebral Ventricles; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Injections, Intraventricular; Kinetics; Molecular Sequence Data; Myenteric Plexus; Naloxone; Nociceptors; Oligopeptides; Opioid Peptides; Pain; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Skin; Skin Physiological Phenomena; Structure-Activity Relationship | 1992 |
Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Benzofurans; Bicuculline; Bombesin; Cholecystokinin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Naloxone; Naltrexone; Neurons; Picrotoxin; Prazosin; Pyrrolidines; Quinoxalines; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Synapses; Tetrodotoxin | 1992 |
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Further studies of the role of opioid receptors in the nigra in the morphine withdrawal syndrome.
Topics: Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Body Temperature; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Morphine Dependence; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Stereotaxic Techniques; Substance Withdrawal Syndrome; Substantia Nigra | 1992 |
The pressor response to central administration of beta-endorphin results from a centrally mediated increase in noradrenaline release and adrenaline secretion.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Injections, Intraventricular; Male; Naloxone; Norepinephrine; Rabbits | 1991 |
Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Behavior, Animal; Clonidine; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1992 |
Dopamine and endogenous opioid regulation of picrotoxin-induced locomotion in the ventral pallidum after dopamine depletion in the nucleus accumbens.
Topics: Animals; Dopamine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Globus Pallidus; Haloperidol; Male; Microinjections; Motor Activity; Naloxone; Nucleus Accumbens; Picrotoxin; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical | 1992 |
Paradoxical analgesia produced by naloxone in diabetic mice is attributable to supersensitivity of delta-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Pain; Pain Measurement; Pyrrolidines; Reaction Time; Time Factors | 1992 |
Effect of centrally administered enkephalins on carrageenin-induced paw oedema in rats.
Topics: Animals; Arthritis, Experimental; Brain; Carrageenan; Edema; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hindlimb; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Injections, Intraventricular; Male; Metyrapone; Morphine; Naloxone; Pituitary-Adrenal System; Rats; Rats, Wistar | 1992 |
Significance of an opiate mechanism in the adjustment of cerebrocortical oxygen consumption and blood flow during hypercapnic stress.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Carbon Dioxide; Cerebral Cortex; Cerebrovascular Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Oxygen Consumption; Rats; Rats, Inbred F344; Reference Values; Regional Blood Flow; Stereoisomerism | 1992 |
Mobilization of calcium from intracellular store as a possible mechanism underlying the anti-opioid effect of angiotensin II.
Topics: Angiotensin II; Calcium; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Neuroblastoma; Potassium Chloride; Saralasin; Tumor Cells, Cultured | 1992 |
Potentiation of the dorsal immobility response following intrastriatal injections of enkephalins.
Topics: Animals; Behavior, Animal; Catalepsy; Corpus Striatum; Enkephalins; Male; Microinjections; Motor Activity; Naloxone; Rats; Reflex | 1992 |
The calcium antagonist diltiazem has antiarrhythmic effects which are mediated in the brain through endogenous opioids.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Blood Pressure; Brain; Diltiazem; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Heart Rate; Injections, Intraventricular; Naloxone; Rats; Rats, Inbred Strains | 1992 |
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
Topics: Aminopeptidases; Analgesia; Analgesics; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Disulfides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Neprilysin; Phenylalanine; Prodrugs; Rats; Rats, Inbred Strains | 1992 |
Differential modulation by mu- and delta-opioids on baroreceptor reflex in conscious rabbits.
Topics: Animals; Blood Pressure; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Injections, Intraventricular; Kidney; Male; Naloxone; Pressoreceptors; Rabbits; Reflex; Sympathetic Nervous System | 1992 |
Naloxone blocks opioid peptide release in N. accumbens and amygdala elicited by morphine injected into periaqueductal gray.
Topics: Amygdala; Animals; beta-Endorphin; Enkephalins; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Perfusion; Periaqueductal Gray; Rabbits; Radioimmunoassay; Stereotaxic Techniques | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Ethanol-induced increase in endogenous dopamine release may involve endogenous opiates.
Topics: Animals; beta-Endorphin; Dopamine; Endorphins; Enkephalin, Leucine; Ethanol; Levodopa; Male; Naloxone; Narcotic Antagonists; Potassium; Rats; Rats, Inbred Strains | 1992 |
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Importance of delta opioid receptors in maintaining high alcohol drinking.
Topics: Alcohol Drinking; Animals; Drinking Behavior; Enkephalin, Leucine; Male; Naloxone; Narcotic Antagonists; Neprilysin; Phenylpropionates; Rats; Receptors, Opioid; Receptors, Opioid, delta; Thiorphan | 1991 |
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Modulation of NMDA-induced currents by mu-opioid receptor agonist DAGO in acutely isolated rat spinal dorsal horn neurons.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; N-Methylaspartate; Naloxone; Neurons; Neurons, Afferent; Rats; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Synaptic Transmission; Tetrodotoxin | 1991 |
Endogenous opioids tonically inhibit the depressor neurones in the caudal ventrolateral medulla of rabbits: mediation through delta- and kappa-receptors.
Topics: Amino Acid Sequence; Animals; Endorphins; Enkephalin, Leucine; Hemodynamics; Male; Medulla Oblongata; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1991 |
Regulation of endogenous calcium and magnesium levels by delta opioid receptors in the rat brain.
Topics: Analgesics; Animals; Brain Chemistry; Calcium; Cations, Divalent; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Magnesium; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spectrophotometry, Atomic | 1991 |
Characteristics of mu and delta opioid binding sites in striatal slices of morphine-tolerant and -dependent mice.
Topics: Analgesics; Animals; Binding Sites; Corpus Striatum; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; Morphine Dependence; Naloxone; Pain; Receptors, Opioid | 1991 |
The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo.
Topics: Analgesics; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Beta-adrenoceptor-sensitive adenylate cyclase is inhibited by activation of mu-opioid receptors in rat striatal neurons.
Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoproterenol; Male; Naloxone; Neuroglia; Neurons; Norepinephrine; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
[Evaluation of the discriminative stimulus effect of an enkephalin analog, EK-399, in the rat].
Topics: Animals; Discrimination, Psychological; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Leucine-enkephalin increases the level of inositol (1,4,5) triphosphate and releases calcium from an intracellular pool in rat ventricular cardiac myocytes.
Topics: Animals; Caffeine; Calcium; Enkephalin, Leucine; Heart; Heart Ventricles; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Myocardium; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Ryanodine; Sarcoplasmic Reticulum; Second Messenger Systems | 1991 |
Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.
Topics: Alkylation; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Vas Deferens | 1991 |
Effects of intracerebroventricular administration of opiate receptor antagonists on the suppressed pulsatile LH release during acute fasting in ovariectomized estradiol-treated rats.
Topics: Animals; Azocines; Enkephalin, Leucine; Estradiol; Fasting; Female; Injections, Intraventricular; Luteinizing Hormone; Naloxone; Narcotic Antagonists; Ovariectomy; Periodicity; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
In vitro effect of high doses of morphine on Con A induced lymphokine production.
Topics: Animals; beta-Endorphin; Cell Survival; Cells, Cultured; Clone Cells; Colforsin; Concanavalin A; Cyclic AMP; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Enkephalins; Female; Lymphocyte Activation; Lymphokines; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Protein Biosynthesis; Receptors, Opioid; Spleen; T-Lymphocytes, Helper-Inducer | 1991 |
Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Norepinephrine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Trimebutine | 1991 |
The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: correlation of nociceptive behavior and c-fos expression.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Foot; Formaldehyde; Gene Expression Regulation; Injections, Intraventricular; Male; Molecular Sequence Data; Naloxone; Neurons; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Single-Blind Method; Spinal Cord | 1991 |
Sleep deprivation decreases mu and delta opioid receptor binding in the rat limbic system.
Topics: Animals; Arousal; Behavior, Animal; beta-Endorphin; Brain Chemistry; Densitometry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Limbic System; Male; Membranes; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sleep Deprivation | 1991 |
Effects of local delta and mu opioid receptor activation on basal and stimulated dopamine release in striatum and nucleus accumbens of rat: an in vivo electrochemical study.
Topics: Action Potentials; Animals; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Nucleus Accumbens; Potassium; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
The actions of fentanyl to inhibit drug-induced emesis.
Topics: Animals; Antiemetics; Apomorphine; Autoradiography; Brain Stem; Cisplatin; Copper; Copper Sulfate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Fentanyl; Ferrets; Male; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Vomiting | 1991 |
Effects of continuous naloxone administration on ventral tegmental self-stimulation.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Naloxone; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Self Stimulation; Tegmentum Mesencephali; Time Factors | 1991 |
[The localization of opiate receptors on the inner surface of the cell membrane].
Topics: Acetylcholine; Animals; Cell Membrane; Enkephalins; Helix, Snails; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Neurons; Receptors, Opioid; Surface Properties | 1991 |
Opioid-receptor-mediated inhibition of [3H]dopamine but not [3H]noradrenaline release from rat mediobasal hypothalamus slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dopamine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ergolines; Hypothalamus, Middle; Male; Naloxone; Narcotic Antagonists; Norepinephrine; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
An enkephalinergic mechanism involved in amygdaloid suppression of affective defence behavior elicited from the midbrain periaqueductal gray in the cat.
Topics: Affect; Aggression; Amygdala; Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalins; Female; Fluorescent Dyes; Homocysteine; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Stilbamidines | 1991 |
[Participation of central and peripheral mu- and delta opiate receptors in anti-arrhythmia action of enkephalins].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Myocardial Infarction; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Ventricular Fibrillation | 1991 |
Limitedly selective action of a delta-agonistic leu-enkephalin on the transmission in spinal motor reflex pathways in cats.
Topics: Afferent Pathways; Analgesics; Animals; Cats; Enkephalin, Leucine; Injections, Intravenous; Naloxone; Neural Inhibition; Nociceptors; Reflex, Monosynaptic; Spinal Cord; Synaptic Transmission | 1991 |
Genetic influences in opioid analgesic sensitivity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1991 |
Delta opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Evoked Potentials; Hippocampus; Male; Naloxone; Narcotic Antagonists; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, delta; Synapses; Synaptic Transmission; Time Factors | 1991 |
Interaction between opiate subtype and alpha-2 adrenergic agonists in suppression of noxiously evoked activity of WDR neurons in the spinal dorsal horn.
Topics: Adrenergic alpha-Agonists; Animals; Anterior Horn Cells; Cats; Clonidine; Drug Interactions; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Characterization of opioid-sensitive neurons in the anteroventral third ventricle region of polydipsic inbred mice in vitro.
Topics: Angiotensin II; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Drinking Behavior; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypothalamus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Neurons; Peptide Fragments; Species Specificity | 1991 |
Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb.
Topics: Adenylyl Cyclases; Alkaloids; Animals; beta-Endorphin; Calcium; Cholera Toxin; Cyclic AMP; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enzyme Activation; Guanosine Triphosphate; Intracellular Fluid; Kinetics; Male; Naloxone; Olfactory Bulb; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Opioid; Staurosporine; Stimulation, Chemical | 1991 |
Inhibition by opioids of phagocytosis in peritoneal macrophages.
Topics: Animals; beta-Endorphin; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Erythrocytes; Macrophages; Mice; Morphine; Naloxone; Peritoneal Cavity; Phagocytosis; Sheep | 1991 |
Beta-endorphin: a highly selective endogenous opioid agonist for presynaptic mu opioid receptors.
Topics: Animals; beta-Endorphin; Brain; Culture Techniques; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Neurotransmitter Agents; Norepinephrine; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Evidence for mu opiate receptors on inhibitory terminals in area CA1 of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Barium; Bicuculline; Dendrites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Ion Channel Gating; Naloxone; Nerve Endings; Potassium Channels; Quinoxalines; Rats; Receptors, GABA-A; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration | 1991 |
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes | 1991 |
Opioids can produce a concentration-dependent naloxone-reversible enhancement of inhibition of evoked enkephalin release.
Topics: Analgesics; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Naloxone; Narcotics; Parasympatholytics; Sufentanil; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Effect of opioid peptides on electrically evoked acetylcholine release from Torpedo electromotor neurons.
Topics: Acclimatization; Acetylcholine; Animals; Dynorphins; Electric Organ; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Motor Neurons; Naloxone; Seasons; Torpedo | 1991 |
Mu-opioid-receptor-mediated inhibition of the N-type calcium-channel current.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Humans; Membrane Potentials; Naloxone; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by mu-opioids.
Topics: Afferent Pathways; Animals; Aspartic Acid; Capsaicin; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kinetics; Naloxone; Nerve Fibers; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1991 |
Physiological interactions between enkephalin and excitatory amino acids in the cerebellar cortex of the opossum Didelphis marsupialis virginiana.
Topics: Animals; Aspartic Acid; Cerebellar Cortex; Drug Interactions; Electrophysiology; Enkephalins; Female; Glutamates; Glutamic Acid; Iontophoresis; Male; Naloxone; Opossums; Purkinje Cells | 1991 |
Effect of opioid receptor antagonists on vasodilator nerve actions in the perfused rat mesentery.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanethidine; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Vasodilation | 1991 |
Neuroendocrine control of the gonads.
Topics: Animals; Brain; Endorphins; Enkephalins; Female; Gonads; Humans; Hypothalamus; Male; Naloxone; Neurosecretory Systems; Neurotransmitter Agents; Ovary; Oxidopamine; Rats; Testis; Testosterone; Vagus Nerve; Vasectomy | 1991 |
Modulation of a peripheral inflammatory response to substance P by locally administered opioid receptor agonists.
Topics: Administration, Topical; Amino Acid Sequence; Animals; Blister; Capillary Permeability; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Inflammation; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Perfusion; Peripheral Nerves; Rats; Skin; Substance P; Vasodilation | 1990 |
Neuropeptide release from isolated myenteric nerve endings derived from the guinea pig myenteric plexus.
Topics: Animals; Atropine; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Myenteric Plexus; Naloxone; Nerve Endings; Neurokinin A; Neuropeptides; Substance P; Xanthines | 1990 |
Postnatal development of opioid regulation of micturition in the kitten.
Topics: Animals; Animals, Newborn; Cats; Endorphins; Enkephalin, Leucine; Ganglia, Parasympathetic; Immunohistochemistry; Morphine; Naloxone; Reflex; Spinal Cord; Staining and Labeling; Urinary Bladder; Urination | 1990 |
Morphine, but not sodium cromoglycate, modulates the release of substance P from capsaicin-sensitive neurones in the rat trachea in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Bradykinin; Capsaicin; Cromolyn Sodium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Neurons; Potassium Chloride; Pyrrolidines; Rats; Rats, Inbred Strains; Substance P; Trachea | 1991 |
Atrial natriuretic polypeptide secretion via selective activation of kappa-opioid receptor: role of dynorphin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzomorphans; Cells, Cultured; Diuretics; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart; Heart Atria; Kinetics; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Significance of substance P- and enkephalin-peptide systems in the male genital tract.
Topics: Animals; Cattle; Enkephalins; Genitalia, Male; Humans; In Vitro Techniques; Male; Naloxone; Prostate; Rats; Semen; Seminal Vesicles; Sperm Motility; Spermatozoa; Substance P; Vas Deferens | 1991 |
In vivo bidirectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-enkephalin: reversibility by naloxone.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Cytotoxicity, Immunologic; Enkephalin, Leucine; G(M1) Ganglioside; Glycosphingolipids; Killer Cells, Natural; Male; Mice; Mice, Inbred CBA; Naloxone; Spleen | 1992 |
Transcranial electrical stimulation with Limoge's currents decreases halothane requirements in rats. Evidence for the involvement of endogenous opioids.
Topics: Anesthesia, Inhalation; Animals; Electric Stimulation; Enkephalins; Halothane; Male; Methysergide; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Ritanserin; Thiorphan; Yohimbine | 1992 |
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
Topics: Analgesics; Animals; Binding, Competitive; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Neprilysin; Tissue Distribution; Tritium | 1991 |
Immunomodulatory activity of mu- and kappa-selective opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibody Formation; Antibody-Producing Cells; Benzeneacetamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunosuppression Therapy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Enkephalin lowers vascular resistance in dog hindlimb via a peripheral nonlimb site.
Topics: Animals; Dogs; Enkephalin, Methionine; Enkephalins; Female; Hindlimb; Injections, Intra-Arterial; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Regional Blood Flow; Vascular Resistance | 1991 |
Morphine and (D-Ala2, NMe-Phe4, Gly-ol)-enkephalin increase the intracellular free calcium in isolated rat myocytes--effect of naloxone or pretreatment with morphine.
Topics: Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Fura-2; Heart; In Vitro Techniques; Morphine; Myocardium; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Effects of selective opioid agonists on feline colonic transit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cattle; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Loperamide; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
Topics: Animals; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Dextromethorphan; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ketamine; Locus Coeruleus; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Opioid Peptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1990 |
Regional responses of rat brain opioid receptors upon castration and testosterone replacement.
Topics: Animals; Brain; Enkephalins; Male; Naloxone; Orchiectomy; Rats; Rats, Inbred Strains; Receptors, Opioid; Testosterone | 1990 |
Enkephalins modulate inhibitory neuromuscular transmission in circular muscle of human colon via delta-opioid receptors.
Topics: Action Potentials; Adenosine Triphosphate; Aged; Aged, 80 and over; Colon; Depression, Chemical; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalins; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle, Smooth; Naloxone; Narcotic Antagonists; Neuromuscular Junction; Receptors, Opioid; Serotonin; Synaptic Transmission; Vasoactive Intestinal Peptide | 1990 |
Local opioid receptors mediating antinociception in inflammation: endogenous ligands.
Topics: Animals; Endorphins; Enkephalin, Leucine; Inflammation; Naloxone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
The antinociceptive role of mu- and delta-opiate receptors and their interactions in the spinal dorsal horn of cats.
Topics: Analgesics, Opioid; Animals; Cats; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ganglia, Spinal; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Reflex peristalsis in the guinea pig isolated ileum is endogenously controlled by kappa opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peristalsis; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Somatostatin | 1990 |
Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Neurons, Afferent; Oligopeptides; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Reserpine | 1990 |
Effect of opioids on acetylcholine release evoked by K+ or glutamic acid from rat neostriatal slices.
Topics: Acetylcholine; Animals; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamates; Glutamic Acid; In Vitro Techniques; Luminescent Measurements; Male; Morphine; Naloxone; Narcotics; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1990 |
Membrane properties and response to opioids of identified dopamine neurons in the guinea pig hypothalamus.
Topics: Action Potentials; Animals; Cell Membrane; Dopamine; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estradiol; Female; Guinea Pigs; Hypothalamus; In Vitro Techniques; Male; Membrane Potentials; Naloxone; Neurons; Ovariectomy; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Tyrosine 3-Monooxygenase | 1990 |
Inhibition by enkephalin of medial vestibular nucleus neurons responding to horizontal pendular rotation.
Topics: Animals; Cats; Electrophysiology; Enkephalins; Glutamates; Glutamic Acid; Iontophoresis; Naloxone; Neurons; Rotation; Vestibular Nuclei | 1990 |
Comparative studies on the effects of some enkephalin agonists on the ERG of frog and turtle.
Topics: Animals; Electroretinography; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Morphine; Naloxone; Rana ridibunda; Receptors, Opioid; Retina; Sympatholytics; Turtles | 1990 |
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan | 1990 |
Differentiation of acupuncture and nonacupuncture points by difference of associated opioids in the spinal cord in production of analgesia by acupuncture and nonacupuncture point stimulation, and relations between sodium and those opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acupuncture Analgesia; Acupuncture Points; Analgesics; Animals; Benzomorphans; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride; Spinal Cord | 1990 |
Effects of intracerebroventricular injection of dynorphin, leumorphin and alpha neo-endorphin on operant feeding in pigs.
Topics: Animals; Appetitive Behavior; Brain; Conditioning, Operant; Dynorphins; Endorphins; Enkephalins; Feeding Behavior; Female; Injections, Intraventricular; Male; Motivation; Naloxone; Peptide Fragments; Protein Precursors; Receptors, Opioid; Swine | 1990 |
Different mechanisms mediating tail-flick inhibition induced by beta-endorphin, DAMGO and morphine from ROb and GiA in anesthetized rats.
Topics: Analgesia; Animals; beta-Endorphin; Brain Stem; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Methysergide; Morphine; Naloxone; Raphe Nuclei; Rats; Rats, Inbred Strains; Yohimbine | 1991 |
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Hydroxamic Acids; Male; Mice; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains | 1991 |
Spinally mediated opioid antidiarrheal effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidiarrheals; Body Weight; Diarrhea; Dinoprostone; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Pyrrolidines; Spinal Cord | 1991 |
Endogenous opioids released from perforant path modulate norepinephrine actions and inhibitory postsynaptic potentials in guinea pig CA3 pyramidal cells.
Topics: Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hippocampus; Male; Membrane Potentials; Naloxone; Norepinephrine; Propranolol; Pyramidal Tracts; Synapses | 1991 |
Only tyrosine-containing metabolites of [Leu]enkephalin impair active avoidance conditioning in mice.
Topics: Amino Acid Sequence; Animals; Avoidance Learning; Enkephalin, Leucine; Male; Mice; Molecular Sequence Data; Motor Activity; Naloxone; Oligopeptides; Tyrosine | 1990 |
Responses of morphine dependent opioid neurones to stressors.
Topics: Animals; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Morphine Dependence; Naloxone; Neurons; Pregnancy; Rats; Stress, Physiological; Tissue Distribution | 1990 |
Agonist-selective protection of the opioid receptor-coupled G proteins from inactivation by 5'-p-fluorosulphonylbenzoyl guanosine.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Brain; Cell Membrane; Dithiothreitol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Guanosine; Guanylyl Imidodiphosphate; Iodoacetamide; Kinetics; Molecular Sequence Data; Naloxone; Rats; Receptors, Opioid | 1990 |
Effects of a selective mu opioid receptor agonist and naloxone on the intake of sodium chloride solutions.
Topics: Animals; Drinking; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, mu; Sodium Chloride; Taste; Water Deprivation | 1990 |
Effects of calcium-channel blockers (CCB) on mu and delta opioid receptors in rat brain membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Mu-opioid receptor-mediated inhibition of D-1 dopamine receptor stimulated adenylate cyclase in primary cultures of rat neostriatal neurons.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Naloxone; Neurons; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Opioid involvement in epileptogenic and neurovisceral activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Digestive System; Enkephalin, Leucine; Enkephalin, Methionine; Epilepsy; Kainic Acid; Male; Mice; Naloxone; Nervous System; Pyrrolidines; Receptors, Opioid | 1990 |
Naloxone-induced withdrawal syndrome after administration of selective opioid agonists or after activation of the endogenous enkephalinergic system.
Topics: Animals; Behavior, Animal; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Weight Loss | 1990 |
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses.
Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1990 |
[Participation of agonists and antagonist of opiate receptors in the regulation of contractile activity of lymphatic microvessels of the rat mesentery].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lymphatic System; Male; Mesentery; Naloxone; Rats; Receptors, Opioid; Sympatholytics | 1990 |
Intrathecal administration of delta receptor agonists in the urethane anesthetized rat provokes an increase in arterial pressure via a non-opioid mechanism.
Topics: Anesthesia; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Injections, Spinal; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord; Urethane | 1990 |
Opioids modulate interleukin-1 production and secretion by bone-marrow macrophages.
Topics: Animals; beta-Endorphin; Bone Marrow Cells; Drug Synergism; Endorphins; Enkephalins; Interleukin-1; Lipopolysaccharides; Macrophages; Mice; Naloxone; Protein Precursors; Silicon Dioxide | 1990 |
Mu-opiate receptor binding in the medial preoptic area is cyclical and sexually dimorphic.
Topics: Animals; Benzomorphans; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrus; Female; Male; Naloxone; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sex Characteristics | 1990 |
[The antinociceptive properties of dalargin as an agent of anesthesiologic protection].
Topics: Analgesics; Androstane-3,17-diol; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hemodynamics; Male; Muscle Relaxants, Central; Muscle Relaxation; Naloxone; Pipecuronium; Piperazines; Rats; Rats, Inbred Strains | 1990 |
Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine.
Topics: Chemical Phenomena; Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Isothiocyanates; Lactones; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Morphinans; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Spectrophotometry, Infrared; Stereoisomerism; Thebaine; Thiocyanates | 1990 |
Delta-opioid receptor binding sites in rodent spinal cord.
Topics: Analgesics; Animals; Autoradiography; Binding, Competitive; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Injections, Spinal; Male; Mesocricetus; Mice; Mice, Inbred Strains; Naloxone; Psychomotor Performance; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Interaction of newly synthesized N-cyclopropylmethyl derivatives of (-)-6 beta-acetylthionormorphine with opioid receptors.
Topics: Analgesics; Animals; Brain; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naloxone; Pain Measurement; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptosomes; Vas Deferens | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
Effects of mu-opioid receptor agonists on circulatory responses to simulated haemorrhage in conscious rabbits.
Topics: Animals; Blood Gas Analysis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hematocrit; Hemodynamics; Hemorrhage; Injections, Intraventricular; Morphine; Naloxone; Narcotics; Rabbits; Receptors, Opioid; Receptors, Opioid, mu; Respiration | 1990 |
Ontogenesis of cell surface mu-opioid ([3H]DAGO) binding sites in rat hypothalamus and ex vivo determination of blood-brain barrier penetration by opioid peptide FK 33-824.
Topics: Aging; Animals; Binding, Competitive; Blood-Brain Barrier; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamus; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
[3H]naloxone as an opioid receptor label: analysis of binding site heterogeneity and use for determination of opioid affinities of casomorphin analogues.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Binding Sites; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Male; Molecular Sequence Data; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1990 |
Differences in physical dependence induced by selective mu or delta opioid agonists and by endogenous enkephalins protected by peptidase inhibitors.
Topics: Animals; Cerebral Ventricles; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Injections, Intraventricular; Male; Naloxone; Neprilysin; Oligopeptides; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Opioids hyperpolarize beta-endorphin neurons via mu-receptor activation of a potassium conductance.
Topics: Action Potentials; Animals; Bacterial Proteins; beta-Endorphin; Cell Membrane; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Antibody Technique; Fluorescent Dyes; Guinea Pigs; Lysine; Membrane Potentials; Microscopy, Fluorescence; Naloxone; Neurons; Potassium Channels; Receptors, Opioid; Receptors, Opioid, mu; Streptavidin; Thiocyanates | 1990 |
Naloxone benzoylhydrazone (NalBzoH) analgesia.
Topics: Analgesia; Analgesics; Animals; Azocines; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming; Thiorphan | 1990 |
Differential effects of cyanogen bromide on ligand binding by mu, delta and kappa opioid receptors.
Topics: Animals; Brain; Cell Membrane; Cyanogen Bromide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ligands; Male; Methionine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Role of opioid receptors in the long-lasting blood pressure depression after electric muscle stimulation in the hind leg of the rat.
Topics: Animals; Benzomorphans; Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart Rate; Hindlimb; Male; Naloxone; Naltrexone; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Receptors, Opioid; Regional Blood Flow | 1990 |
Hyperpolarizing action of enkephalin on neurons in the dorsal motor nucleus of the vagus, in vitro.
Topics: Action Potentials; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Medulla Oblongata; Membrane Potentials; Naloxone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vagus Nerve | 1990 |
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation | 1990 |
Neuroendocrine control of thymic hormonal production. II. Stimulatory effects of endogenous opioids on thymulin production by cultured human and murine thymic epithelial cells.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epithelium; Fluorescent Antibody Technique; Humans; Mice; Mice, Inbred C57BL; Naloxone; Rats; Thymic Factor, Circulating; Thymus Gland; Thymus Hormones | 1990 |
Physical dependence potential of an enkephalin analog, EK-399, in rats.
Topics: Animals; Body Weight; Enkephalins; Infusions, Intravenous; Male; Meperidine; Morphine; Naloxone; Opioid-Related Disorders; Pentazocine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1990 |
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior | 1990 |
The modulating influence of enkephalins on the bone marrow haemopoiesis in stress.
Topics: Animals; Bone Marrow; Cell Count; Cell Differentiation; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hematopoiesis; Male; Mice; Naloxone; Phenylalanine; Restraint, Physical; Stress, Physiological; Time Factors | 1990 |
Effects of iontophoresed opioids on physiologically characterized laminae I and II dorsal horn neurons in the cat spinal cord.
Topics: Animals; Cats; Decerebrate State; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydrogen-Ion Concentration; Iontophoresis; Morphine; Naloxone; Neurons; Spinal Cord | 1990 |
Effects of iontophoretically applied alpha-casein exorphin on CA1 hippocampal field potentials in vivo.
Topics: Amino Acid Sequence; Animals; Caseins; Electric Stimulation; Enkephalin, Leucine; Evoked Potentials; Hippocampus; Iontophoresis; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains | 1990 |
Alteration of thermoregulatory set point with opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature Regulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains | 1990 |
Administration of leu-enkephalin impairs the acquisition of preference for ethanol.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Enkephalin, Leucine; Ethanol; Male; Naloxone; Rats; Rats, Inbred Strains | 1990 |
Enkephalinergic and GABAergic modulation of motor activity in the ventral pallidum.
Topics: Animals; Basal Ganglia; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA Antagonists; Male; Microinjections; Motor Activity; Muscimol; Naloxone; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Innominata | 1990 |
Antinociceptive activity of glycosidic enkephalin analogues.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalins; Injections, Intraventricular; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains | 1990 |
[Effect of enkephalins and naloxone on the activity of the kallikrein-kinin system in experimental hemorrhagic shock].
Topics: Animals; Enkephalins; Kallikreins; Kinins; Male; Naloxone; Rats; Rats, Inbred Strains; Shock, Hemorrhagic | 1990 |
2-substituted-N5-(2'-aminophenyl)-4-thiohydantoic acids as aminopeptidase inhibitors with pro-antinociceptive activity.
Topics: Aminopeptidases; Analgesics; Animals; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydantoins; In Vitro Techniques; Mice; Naloxone; Pain Measurement; Puromycin; Thiohydantoins | 1990 |
Central and local actions of opioids upon reticulo-ruminal motility in sheep.
Topics: Animals; Bradykinin; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Loperamide; Morphine Derivatives; Muscle Contraction; Naloxone; Narcotics; Prostaglandins E; Reticulum; Rumen; Sheep; Substance P | 1985 |
Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration.
Topics: Action Potentials; Animals; beta-Endorphin; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Protein Precursors; Receptors, Opioid; Sodium; Time Factors | 1985 |
Opioid inhibition of synaptic transmission in the guinea-pig myenteric plexus.
Topics: Acetylcholine; Action Potentials; Animals; Barium; Electric Conductivity; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Guinea Pigs; Ileum; Morphine; Myenteric Plexus; Naloxone; Nicotine; Potassium; Substance P; Synaptic Transmission | 1985 |
Mu- and delta-opioid receptor-mediated epileptoid responses in morphine-dependent and non-dependent rats.
Topics: Animals; Electroencephalography; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epilepsy; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome | 1985 |
Opioid control of the function of primary afferent substance P fibres.
Topics: Afferent Pathways; Animals; Electric Stimulation; Enkephalins; Fentanyl; In Vitro Techniques; Naloxone; Perfusion; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Vasodilation | 1985 |
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
Topics: Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1985 |
Irreversible opiate agonists and antagonists. III. Phenylhydrazone derivatives of naloxone and oxymorphone.
Topics: Albumins; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrazones; Hydromorphone; In Vitro Techniques; Male; Naloxone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship; Tritium | 1985 |
Inhibition of dopamine-stimulated cyclic AMP efflux from rat neostriatal slices by activation of mu- and delta-opioid receptors: a permissive role for D-2 dopamine receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Corpus Striatum; Cyclic AMP; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Analgesia after inhibition of enkephalin degradation.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Neprilysin; Protease Inhibitors; Spinal Cord; Substance P; Thiorphan; Tiopronin | 1986 |
Enkephalins increase cyclic adenosine monophosphate content, calcium uptake, and contractile state in cultured chick embryo heart cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Chick Embryo; Cyclic AMP; Enkephalin, Methionine; Enkephalins; GTP-Binding Proteins; Heart; Myocardial Contraction; Myocardium; Naloxone | 1986 |
Enkephalin and substance P modulate synaptic properties of chick ciliary ganglion neurons in cell culture.
Topics: Acetylcholine; Action Potentials; Animals; Calcium; Cells, Cultured; Chick Embryo; Enkephalins; Evoked Potentials, Somatosensory; Ganglia, Parasympathetic; Kinetics; Membrane Potentials; Naloxone; Neurons; Substance P | 1986 |
Opposite effects of delta and mu opioid receptor agonists on the in vitro release of substance P-like material from the rat spinal cord.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Male; Morphine; Naloxone; Oligopeptides; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Tetrodotoxin; Veratridine | 1987 |
Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Dose-Response Relationship, Drug; Electric Conductivity; Enkephalin, Leucine; Glioma; Ion Channels; Naloxone; Neuroblastoma; Rats; Somatostatin | 1986 |
The effects of endorphins on mucous glycoprotein secretion from feline airways in vitro.
Topics: alpha-Endorphin; Animals; beta-Endorphin; Cats; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Endorphin; Glycoproteins; Morphine; Mucus; Naloxone; Organ Culture Techniques; Secretory Rate; Trachea | 1987 |
[Emetic and antiemetic properties of regulatory peptides].
Topics: Adrenocorticotropic Hormone; Animals; Antiemetics; beta-Lipotropin; Cats; Dose-Response Relationship, Drug; Drug Interactions; Emetics; Endorphins; Enkephalins; Injections, Intraventricular; Morphine; Naloxone; Peptides; Substance P; Time Factors | 1987 |
Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Diltiazem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immobilization; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Nifedipine; Pain; Reaction Time; Stress, Physiological; Verapamil | 1987 |
Dynorphin and related opioid peptides enhance tumoricidal activity mediated by murine peritoneal macrophages.
Topics: Animals; Cytotoxicity, Immunologic; Dynorphins; Enkephalin, Leucine; Interferons; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Naloxone; Neoplasms, Experimental; Peptide Fragments; Peritoneal Cavity; Receptors, Opioid | 1987 |
Hybrid bivalent ligands with opiate and enkephalin pharmacophores.
Topics: Analgesics; Animals; Enkephalins; Guinea Pigs; Hydromorphone; Ligands; Male; Mice; Muscle, Smooth; Naloxone; Oxymorphone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Modulation of humoral immune responses by endogenous opioids.
Topics: Anaphylaxis; Animals; Antibody Formation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Histamine Release; Mice; Morphine; Naloxone; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Rats | 1988 |
Somatostatin increases an inwardly rectifying potassium conductance in guinea-pig submucous plexus neurones.
Topics: Action Potentials; Animals; Cesium; Colforsin; Enkephalins; Guinea Pigs; In Vitro Techniques; Ion Channels; Naloxone; Neurons; Norepinephrine; Potassium; Rubidium; Somatostatin; Submucous Plexus; Thionucleotides; Time Factors | 1987 |
Irreversible opiate agonists and antagonists. IV. Analgesic actions of 14-hydroxydihydromorphinone hydrazones.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrazones; Hydromorphone; Male; Mice; Naloxone; Oxymorphone; Receptors, Opioid; Time Factors | 1988 |
Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures.
Topics: Action Potentials; Animals; Barium; Calcium; Cesium; Chlorides; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fetus; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Neurons, Afferent; Organ Culture Techniques; Potassium; Tetraethylammonium; Tetraethylammonium Compounds | 1988 |
Substance P and [leucine]enkephalin release in guinea pig ileum during naloxone-precipitated morphine withdrawal.
Topics: Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Morphine Dependence; Myenteric Plexus; Naloxone; Substance P; Substance Withdrawal Syndrome | 1989 |
Endogenous opioids and immune responses: an experimental study.
Topics: Anaphylaxis; Animals; Antibody Formation; Endorphins; Enkephalin, Leucine; Female; Hemagglutination; Histamine Release; Immunity; Male; Mice; Morphine; Naloxone; Passive Cutaneous Anaphylaxis; Rats; Rats, Inbred Strains | 1988 |
Enkephalinergic modulation of the dopamine system in the turtle retina.
Topics: Animals; Autoradiography; Cell Count; Dopamine; Dopamine Antagonists; Enkephalins; gamma-Aminobutyric Acid; Immunoenzyme Techniques; Naloxone; Neurons; Potassium; Retina; Turtles | 1989 |
A novel action of morphine in the rat locus coeruleus: persistent decrease in adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Locus Coeruleus; Male; Morphine; Naloxone; Opioid-Related Disorders; Rats; Rats, Inbred Strains | 1989 |
Effect of enkephalins on cardiac output and regional blood flow in conscious dogs.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Naloxone; Organ Specificity; Oxygen; Partial Pressure; Reference Values; Regional Blood Flow; Respiration | 1989 |
Nonopiate active proenkephalin-derived peptides are secreted by T helper cells.
Topics: Adrenal Glands; Animals; Brain; Cattle; Chromatography, Gel; Endorphins; Enkephalins; Mice; Mice, Inbred CBA; Naloxone; Peptides; Radioimmunoassay; Rats; T-Lymphocytes, Helper-Inducer | 1989 |
Activation of central mu-opioid receptors is involved in clonidine analgesia in rats.
Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Male; Naloxone; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Species Specificity | 1989 |
Selective inhibitory effects of ethylketocyclazocine on reflex pathways to the external urethral sphincter of the cat.
Topics: Animals; Cats; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Urethra; Urinary Bladder; Urinary Incontinence | 1989 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds | 1989 |
Influence of opioid peptides on learning and memory processes in the chick.
Topics: Animals; Attention; beta-Endorphin; Brain Mapping; Chickens; Discrimination Learning; Dominance, Cerebral; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Memory; Mental Recall; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Visual Cortex | 1989 |
Dermorphin inhibits micturition reflex in rats at a central site of action.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Spinal; Male; Naloxone; Oligopeptides; Opioid Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Urination | 1989 |
Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Male; Morphine; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Alternated delta and mu receptor activation: a stratagem for limiting opioid tolerance.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Infusion Pumps; Injections, Intraperitoneal; Morphine; Naloxone; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 1989 |
Lateralization of opioid receptors in turtle visual cortex.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Evoked Potentials, Visual; Functional Laterality; Morphine; Naloxone; Receptors, Opioid; Turtles; Visual Cortex | 1989 |
Opioids induce postural asymmetry in spinal rat: the side of the flexed limb depends upon the type of opioid agonist.
Topics: Animals; Benzomorphans; Decerebrate State; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Functional Laterality; Male; Muscles; Naloxone; Narcotics; Phenazocine; Posture; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Time Factors | 1989 |
Inhibition of adrenergic transmission by methionine- and leucine-enkephalins is impaired in the mesenteric vasculatures of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Hypertension; Male; Mesenteric Arteries; Naloxone; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Sympathetic Nervous System; Synaptic Transmission | 1989 |
Substantia nigra as a site of origin of dopamine-dependent motor syndromes induced by stimulation of mu and delta opioid receptors.
Topics: Animals; Dopamine; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Substantia Nigra | 1989 |
Effects of selective opioid-receptor blockade on the hypothalamo-pituitary-adrenocortical responses to surgical trauma in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological | 1989 |
The effects of drugs interacting with opioid receptors on the early ventricular arrhythmias arising from myocardial ischaemia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Coronary Vessels; Enkephalin, Leucine; Heart Rate; Heroin; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1989 |
14 beta-(Bromoacetamido)morphine irreversibly labels mu opioid receptors in rat brain membranes.
Topics: Alkylation; Animals; Binding Sites; Brain; Dithiothreitol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Morphine Derivatives; Naloxone; Oxidation-Reduction; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
New glycosylpeptides with high antinociceptive activity.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Naloxone; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Central and peripheral opioid modulation of gastric relaxation induced by feeding in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Dogs; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Morphine; Muscle Relaxation; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagotomy; Vagus Nerve | 1989 |
Inhibition of vagal transmission by cardiac sympathetic nerve stimulation in the dog: possible involvement of opioid receptor.
Topics: Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart; Heart Rate; Methacholine Chloride; Methacholine Compounds; Naloxone; Naltrexone; Norepinephrine; Prazosin; Receptors, Opioid; Sympathetic Nervous System; Synaptic Transmission; Vagus Nerve; Yohimbine | 1989 |
Opiate receptor inhibition improves the blunted baroreflex function in conscious dogs with right-sided congestive heart failure.
Topics: Animals; Blood Pressure; Consciousness; Dogs; Electrocardiography; Enkephalin, Leucine; Heart Failure; Naloxone; Narcotic Antagonists; Oxymorphone; Phenylephrine; Pressoreceptors; Receptors, Opioid; Reflex | 1989 |
mu-Opioid peptide modulation of cardiovascular and sympathoadrenal responses to stress.
Topics: Animals; Blood Pressure; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Restraint, Physical; Stress, Psychological; Time Factors | 1989 |
[Effects of opioid receptor ligands on DNA synthesis and histamine contents in the gastric mucosa and blood of white rats].
Topics: Animals; Anti-Ulcer Agents; Autoradiography; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Histamine; Ligands; Male; Naloxone; Rats; Receptors, Opioid; Spectrometry, Fluorescence | 1989 |
Magnitude of opioid dependence after continuous intrathecal infusion of mu- and delta-selective opioids in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders; Sufentanil; Time Factors | 1989 |
Antitumor activity of enkephalin analogues in inhibiting PYB6 tumor growth in mice and immunological effects of methionine enkephalinamide.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antineoplastic Agents; Enkephalin, Methionine; Enkephalins; Female; Fibrosarcoma; Killer Cells, Natural; Lymphocyte Activation; Mice; Naloxone; Receptors, Opioid; Tumor Cells, Cultured | 1989 |
Indirect involvement of delta opioid receptors in cholecystokinin octapeptide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Sincalide | 1989 |
Multi-dimensional analysis of behavior in mice treated with the delta opioid agonists DADL (D-Ala2-D-Leu5-enkephalin) and DPLPE (D-Pen2-L-Pen5-enkephalin).
Topics: Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Different mu receptor subtypes mediate spinal and supraspinal analgesia in mice.
Topics: Analgesia; Anesthesia, Spinal; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution.
Topics: Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Blood Glucose; Brain Chemistry; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Injections, Intraventricular; Medulla Oblongata; Naloxone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Respiration | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Sympathoadrenal, cardiovascular and blood gas responses to highly selective mu and delta opioid peptides.
Topics: Animals; Blood Pressure; Carbon Dioxide; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Male; Naloxone; Oxygen; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Selectivity for opioid receptor subtypes of enkephalin analogues in isolated smooth muscle and in the analgesic effect in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Electric Stimulation; Enkephalins; Guinea Pigs; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid | 1989 |
A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.
Topics: Anesthetics; Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1989 |
Adrenal responses to splanchnic nerve stimulation in conscious calves given naloxone.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Blood Pressure; Cattle; Corticotropin-Releasing Hormone; Electric Stimulation; Enkephalins; Epinephrine; Naloxone; Norepinephrine; Splanchnic Nerves; Vascular Resistance | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
Interaction of S-activated enkephalin analogs with opiate receptors.
Topics: Animals; Binding Sites; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle, Smooth; Naloxone; Receptors, Opioid; Sulfhydryl Compounds; Vas Deferens | 1989 |
Effect of endogenous opioid peptides on TRH release from rat stomach in vitro.
Topics: Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Gastric Mucosa; In Vitro Techniques; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Stomach; Thyrotropin-Releasing Hormone | 1989 |
Lack of mixed agonist-antagonist properties of [Gln8-Gly31]-beta h-EP-Gly-Gly-NH2 and [Arg9,19,24,28,29]-beta h-EP in the rat vas deferens neuroeffector junction: studies with naloxone, beta-funaltrexamine and ICI 174,864.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neuroeffector Junction; Rats; Rats, Inbred Strains; Vas Deferens | 1989 |
Naloxone-insensitive inhibitory and excitatory effects of opioid agonists in the rat isolated uterus.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Estrus; Female; In Vitro Techniques; Morphine; Naloxone; Narcotics; Potassium Chloride; Rats; Rats, Inbred Strains; Uterine Contraction; Uterus | 1989 |
Evidence that the aversive effects of opioid antagonists and kappa-agonists are centrally mediated.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Conditioning, Operant; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin | 1989 |
Effect of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin on ion and amino acid transport in rabbit ileum.
Topics: Amino Acids; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ileum; In Vitro Techniques; Intestinal Mucosa; Male; Membrane Potentials; Muscle, Smooth; Naloxone; Rabbits; Valine | 1989 |
Amphetamine stereotypy in cats and neurotransmitter interactions in the caudate nucleus. II. Effects of intracaudate injection of leu-enkephalin and naloxone.
Topics: Amphetamine; Animals; Cats; Caudate Nucleus; Enkephalin, Leucine; Injections; Male; Naloxone; Neurotransmitter Agents; Stereotyped Behavior; Time Factors | 1989 |
Facilitatory effects of opioids on the discharges of visceral nociceptors.
Topics: Animals; Bradykinin; Dinoprostone; Dogs; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epididymis; Evoked Potentials; Male; Morphine; Naloxone; Nociceptors; Testis | 1989 |
Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.
Topics: Action Potentials; Animals; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Myenteric Plexus; Naloxone; Sufentanil | 1989 |
Effects of leu-enkephalin on the mechanical activity of longitudinal and circular muscles of the small intestine of the cat.
Topics: Animals; Atropine; Cats; Duodenum; Electric Stimulation; Enkephalin, Leucine; Ileum; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Naloxone | 1989 |
Enkephalinergic inhibition in parasympathetic ganglia of the urinary bladder of the cat.
Topics: Action Potentials; Animals; Cats; Electric Stimulation; Enkephalins; Female; Ganglia, Parasympathetic; Male; Naloxone; Neural Inhibition; Urinary Bladder | 1989 |
Centrally administered opioid peptides stimulate saccharin intake in nondeprived rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Food Preferences; Male; Naloxone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Saccharin; Time Factors | 1989 |
[Effects of opioids on the development of preimplantation mouse embryos].
Topics: Animals; Drug Combinations; Embryonic and Fetal Development; Embryonic Development; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Mice; Mice, Inbred CBA; Naloxone; Pregnancy; Zygote | 1989 |
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Pain; Protease Inhibitors; Reference Values; Species Specificity; Thiorphan | 1989 |
Swim-stress-induced antinociception in young rats.
Topics: Aging; Animals; Animals, Newborn; Enkephalin, Leucine; Female; Male; Naloxone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Stress, Psychological; Swimming | 1989 |
Effects of enkephalins and the analogue FK-33824 on mean arterial pressure and heart rate in conscious sheep.
Topics: Animals; Blood Pressure; Consciousness; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Female; Heart Rate; Injections, Intraventricular; Naloxone; Sheep | 1989 |
In vivo release of CCK-8 from the dorsal horn of the rat: inhibition by DAGOL.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Radioimmunoassay; Rats; Rats, Inbred Strains; Sincalide; Spinal Cord | 1989 |
Potent antinociceptive effects of kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Male; Naloxone; Pain; Rats; Rats, Inbred Strains | 1989 |
Met- and leu-enkephalins inhibit rat cortical neurons intracellularly recorded in vivo while morphine excites them: evidence for naloxone-sensitive and naloxone-insensitive effects.
Topics: Animals; Cerebral Cortex; Electrodes; Enkephalin, Leucine; Enkephalin, Methionine; Male; Membrane Potentials; Morphine; Naloxone; Neurons; Rats; Rats, Inbred Strains | 1989 |
Presynaptic opioid receptors in the portal vein of the rabbit.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Naloxone; Narcotic Antagonists; Narcotics; Portal Vein; Rabbits; Receptors, Opioid | 1987 |
Characterization of rabbit ear artery opioid receptors using a delta-selective agonist and antagonist.
Topics: Animals; Arteries; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Muscle, Smooth; Muscle, Smooth, Vascular; Naloxone; Narcotic Antagonists; Rabbits; Rats; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1987 |
Involvement of opiate receptor subtypes in the modulation of LHRH secretion by the cockerel (Gallus domesticus) mediobasal hypothalamus in vitro.
Topics: Animals; Benzodiazepines; Chickens; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Naloxone; Oligopeptides; Receptors, Opioid | 1987 |
Opioid receptor regulation of the release of norepinephrine in brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Models, Neurological; Naloxone; Norepinephrine; Potassium; Pyrrolidines; Receptors, Opioid | 1987 |
Photoinactivation of the mu opioid receptor using a novel synthetic morphiceptin analog.
Topics: Affinity Labels; Animals; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Light; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Effects of beta-funaltrexamine on radiolabeled opioid binding.
Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
[Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon.
Topics: Animals; Cats; Colon; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1987 |
Delta-opioid receptors mediate inhibition of fast excitatory postsynaptic potentials in cat parasympathetic colonic ganglia.
Topics: Animals; Cats; Colon; Enkephalin, Leucine; Evoked Potentials; Female; Ganglia, Parasympathetic; In Vitro Techniques; Male; Membrane Potentials; Motor Endplate; Naloxone; Narcotic Antagonists; Receptors, Nicotinic; Receptors, Opioid; Receptors, Opioid, delta; Synapses | 1987 |
Subtraction autoradiography of opiate receptor subtypes in human brain.
Topics: Autoradiography; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Humans; Middle Aged; Naloxone; Receptors, Opioid; Subcellular Fractions | 1987 |
Opiate binding sites in the interpeduncular nucleus of the rat: normal distribution and the effects of fasciculus retroflexus lesions.
Topics: Animals; Autoradiography; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Mesencephalon; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Tissue Distribution | 1987 |
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
Topics: Animals; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells.
Topics: Adenylyl Cyclase Inhibitors; Alprostadil; Cell Division; Cell Membrane; Cyclic AMP; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Fatty Acids, Unsaturated; Fluorescence Polarization; Kinetics; Linoleic Acid; Linoleic Acids; Naloxone; Neuroblastoma; Receptors, Opioid; Tumor Cells, Cultured | 1987 |
Binding of naloxone to human T lymphocytes.
Topics: beta-Endorphin; Binding, Competitive; Blood Platelets; Culture Media; Enkephalin, Leucine; Enkephalin, Methionine; Glutathione; Humans; Kinetics; Morphine; Naloxone; Receptors, Opioid; Sonication; T-Lymphocytes | 1987 |
Autoradiographic visualization of sex differences in the pattern and density of opiate receptors in hamster hypothalamus.
Topics: Animals; Autoradiography; Binding Sites; Brain; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estrus; Female; Functional Laterality; Hypothalamus; In Vitro Techniques; Male; Mesocricetus; Naloxone; Receptors, Opioid; Sex Characteristics | 1987 |
Opioid receptors inhibit the adenylate cyclase in guinea pig cochleas.
Topics: Adenylyl Cyclases; Animals; Cochlea; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Naloxone; Oligopeptides; Receptors, Opioid | 1987 |
Chronic morphine upregulates a mu-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography.
Topics: Alkylating Agents; Animals; Binding, Competitive; Drug Tolerance; Enkephalin, Leucine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tomography, Emission-Computed | 1987 |
Opiate-inhibited adenylate cyclase in rat brain membranes depleted of Gs-stimulated adenylate cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Membrane; Cholera Toxin; Colforsin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; Male; Naloxone; Oligopeptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Fluoride; Virulence Factors, Bordetella | 1988 |
Interaction of U-69,593 with mu-, alpha- and kappa-opioid binding sites and its analgesic and intestinal effects in rats.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Male; Naloxone; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid | 1988 |
Pharmacological analysis of the calcium-dependence of mu-receptor agonism.
Topics: Animals; Binding, Competitive; Calcium; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Hyperalgesia produced by intrathecal opioid antagonists depends on receptor selectivity and noxious stimulus.
Topics: Analgesia; Animals; Benzomorphans; Enkephalin, Leucine; Hyperalgesia; Hyperesthesia; Injections, Spinal; Male; Morphinans; Naloxone; Narcotic Antagonists; Pain; Rats; Receptors, Opioid | 1986 |
The role of mu- and delta- opioid receptors on the intestinal propulsion in rats.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Gastrointestinal Transit; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Mu- and delta-opioid modulation of electrically-induced epileptic seizures in mice.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Epilepsy; Mice; Morphine; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1986 |
Selective effects of beta-endorphin infused into the hypothalamus, preoptic area and bed nucleus of the stria terminalis on the sexual and ingestive behaviour of male rats.
Topics: Animals; beta-Endorphin; Cholecystokinin; Enkephalin, Leucine; Feeding Behavior; Hypothalamus, Anterior; Male; Naloxone; Preoptic Area; Rats; Reaction Time; Receptors, Opioid; Sexual Behavior, Animal; Thiazines | 1987 |
[Effect of naloxone on the transmission of acupuncture messages involved in the inhibitory action upon visceral traction reaction--3H-2-deoxyglucose autoradiography].
Topics: Acupuncture Therapy; Animals; Autoradiography; Deoxyglucose; Electric Stimulation Therapy; Enkephalins; Male; Naloxone; Rats; Synaptic Transmission; Transcutaneous Electric Nerve Stimulation | 1987 |
Effects of the opioid peptides [Met5]enkephalin-Arg6-Phe7 and [Met5]enkephalin-Arg6-Gly7-Leu8 on cholinergic neurotransmission in the rabbit isolated atria.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Female; Heart; Heart Rate; In Vitro Techniques; Male; Naloxone; Parasympathetic Nervous System; Propranolol; Rabbits; Synaptic Transmission | 1987 |
Monoclonal anti-idiotypic antibodies to opioid receptors.
Topics: Animals; Antibodies, Monoclonal; Antigens; beta-Endorphin; Brain; Cell Membrane; Cyclic AMP; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybridomas; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin M; Immunosorbent Techniques; Mice; Mice, Inbred BALB C; Naloxone; Rats; Receptors, Opioid; Tumor Cells, Cultured | 1988 |
Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanine Nucleotides; Guinea Pigs; Kinetics; Male; Naloxone; Oligopeptides; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1988 |
Medial thalamic injection of opioid agonists: mu-agonist increases while kappa-agonist decreases stimulus thresholds for pain and reward.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Infusions, Parenteral; Male; Microinjections; Naloxone; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Self Stimulation; Thalamus | 1988 |
Opiate mechanisms in the central amygdala and gastric stress pathology in rats.
Topics: Amygdala; Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Microinjections; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Restraint, Physical; Stomach Ulcer; Stress, Physiological | 1988 |
Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse.
Topics: Analgesia; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Species Specificity | 1988 |
Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: studies with naloxonazine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Enhancement of [3H]DAGO1 binding to rat brain by low concentrations of monovalent cations.
Topics: Animals; Batrachotoxins; Benzomorphans; Brain Chemistry; Cations, Monovalent; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanine Nucleotides; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Naloxone; Rats; Receptors, Opioid; Temperature | 1987 |
Simultaneous modulation of TRH and opioid receptor binding in rat spinal cord after chronic naloxone administration.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Thyrotropin-Releasing Hormone; Spinal Cord; Thyrotropin-Releasing Hormone | 1988 |
Relation of diltiazem binding sites to opioid receptor subtypes in the guinea-pig brain.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Diltiazem; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Naloxone; Radioligand Assay; Receptors, Opioid | 1987 |
[A kinetic model of the interaction of stable GTP analogs with a system of opioid receptors].
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Ligands; Male; Models, Biological; Morphine; Naloxone; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Effect of opioid peptides on the paraventricular nucleus of the guinea pig hypothalamus is mediated by mu-type receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Naloxone; Neurons; Paraventricular Hypothalamic Nucleus; Receptors, Opioid; Receptors, Opioid, mu | 1988 |
ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes.
Topics: Adenosine Diphosphate Ribose; Animals; Brain; Cell Membrane; Digitonin; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Naloxone; Oligopeptides; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Solubility; Virulence Factors, Bordetella | 1988 |
Opiate receptor-mediated decrease in renal nerve activity during hypotensive hemorrhage in conscious rabbits.
Topics: Animals; Consciousness; Enkephalins; Hemorrhage; Hypotension; Kidney; Naloxone; Rabbits; Receptors, Opioid; Sympathetic Nervous System | 1988 |
Differential regulation of mu-opiate receptors in heroin- and morphine-dependent rats.
Topics: Animals; Brain; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sodium; Substance-Related Disorders | 1988 |
Rotational behavior mediated by dopaminergic and nondopaminergic mechanisms after intranigral microinjection of specific mu, delta and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydroxydopamines; Male; Microinjections; Motor Activity; Naloxone; Narcotics; Oxidopamine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rotation | 1988 |
Body temperature response profiles for selective mu, delta and kappa opioid agonists in restrained and unrestrained rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical | 1988 |
The physiological relevance of low agonist affinity binding at opioid mu-receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naloxone; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, mu; Tritium; Vas Deferens | 1988 |
[Effect of opioid peptides on regional hemodynamics in waking rats].
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Injections, Intravenous; Male; Microspheres; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Regional Blood Flow; Wakefulness | 1988 |
Inhibitory opioid receptors in canine pylorus.
Topics: Animals; Diprenorphine; Dogs; Duodenum; Electric Stimulation; Enkephalins; Female; Kinetics; Male; Naloxone; Narcotics; Pressure; Pyloric Antrum; Pylorus; Receptors, Opioid; Saxitoxin | 1988 |
Endogenous opioids and the growth regulation of a neural tumor.
Topics: Animals; Antineoplastic Agents; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Naloxone; Neoplasm Transplantation; Neuroblastoma; Receptors, Opioid | 1988 |
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
Topics: Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Antagonist-induced opioid receptor up-regulation. II. Regionally specific modulation of mu, delta and kappa binding sites in rat brain revealed by quantitative autoradiography.
Topics: Animals; Autoradiography; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substantia Nigra | 1988 |
Study on the receptor subtypes mediating the analgesic action of an enkephalin analog, Tyr-D-Met(O)-Gly-EtPhe-NHNHCOCH3.AcOH (EK-399).
Topics: Analgesics; Animals; Drug Tolerance; Enkephalins; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Rats; Receptors, Opioid | 1988 |
Naloxone-reversible inhibition by opiates of phagocytosis in Tetrahymena thermophila and mouse macrophages.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Macrophages; Mice; Morphine; Naloxone; Narcotics; Pinocytosis; Receptors, Opioid; Tetrahymena | 1988 |
[Participation of the opioid-ergic system in the regulation of afferent reactions of the damaged myocardium].
Topics: Animals; Bradykinin; Butorphanol; Cats; Electrocardiography; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Heart Conduction System; Myocardial Infarction; Naloxone; Neurons, Afferent; Receptors, Opioid | 1988 |
Enkephalins modulate in vivo immune reactions through delta- and mu-opioid receptors.
Topics: Animals; Antibody Formation; Enkephalin, Leucine; Enkephalins; Mice; Mice, Inbred BALB C; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Influence of neonatal opioid blockade or injections of gonadotrophin-releasing hormone on the timing of puberty in female rats: correlation of opioid effects with occupation of hypothalamic mu-opioid receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hypothalamus; Naloxone; Naltrexone; Pituitary Hormone-Releasing Hormones; Rats; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation; Time Factors | 1988 |
Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective mu and delta opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes.
Topics: Animals; Behavior, Animal; Caudate Nucleus; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Motor Activity; Naloxone; Neprilysin; Norepinephrine; Nucleus Accumbens; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Enkephalins modulate excitatory synaptic transmission in the superficial dorsal horn by acting at mu-opioid receptor sites.
Topics: Animals; Enkephalins; In Vitro Techniques; Membrane Potentials; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Spinal Cord; Structure-Activity Relationship; Synapses; Synaptic Transmission | 1988 |
Induction of ornithine decarboxylase in adult rat hippocampal slices.
Topics: Animals; Asparagine; Bucladesine; Cycloheximide; Dactinomycin; Enkephalins; Enzyme Induction; Hippocampus; In Vitro Techniques; Insulin; Kinetics; Naloxone; Ornithine Decarboxylase; Rats; Rats, Inbred Strains | 1988 |
Lack of evidence for epsilon-opioid receptors in the rat vas deferens.
Topics: Animals; Calcium; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1988 |
Enkephalin photoaffinity probes: synthesis and binding properties.
Topics: Affinity Labels; Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Kinetics; Naloxone; Rats; Receptors, Opioid; Structure-Activity Relationship; Ultraviolet Rays | 1988 |
Opiate receptor subtypes in the nucleus tractus solitarii of the cat: the effect of vagal section.
Topics: Animals; Autoradiography; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Female; Male; Medulla Oblongata; Naloxone; Receptors, Opioid; Vagotomy | 1988 |
Involvement of Mu receptors in the opioid-induced increase in the turnover of mouse brain histamine.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Histamine; Male; Methylhistamines; Methylhistidines; Mice; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu; Tetrodotoxin | 1988 |
Inhibition by opioid agonists and enhancement by antagonists of the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation: evidence for the functional role of opioid receptors.
Topics: Adrenal Glands; Animals; Catecholamines; Dogs; Electric Stimulation; Enkephalin, Leucine; Female; Male; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Splanchnic Nerves | 1988 |
Antinociception and paralysis induced by intrathecal dynorphin A.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Motor Activity; Naloxone; Nociceptors; Paralysis; Rats; Rats, Inbred Strains | 1985 |
Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hormones; Naloxone; Protein Conformation; Rats; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin; Structure-Activity Relationship; Synaptosomes | 1985 |
Monoclonal antibody to enkephalins with binding characteristics similar to opiate receptor.
Topics: alpha-Endorphin; Animals; Antibodies, Monoclonal; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Mice; Morphine; Naloxone; Receptors, Opioid | 1985 |
Evidence for a dual mechanism in the anesthetic action of an opioid peptide.
Topics: 1-Octanol; Analgesics, Opioid; Anesthetics; Animals; Atmospheric Pressure; Azocines; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lipids; Naloxone; Narcotic Antagonists; Octanols; Postural Balance; Rana pipiens; Receptors, Opioid; Reflex; Solubility; Time Factors | 1985 |
Treatment of stroke with opiate antagonists--effects of exogenous antagonists and dynorphin 1-13.
Topics: Acute Disease; Animals; Brain Ischemia; Cats; Dynorphins; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments | 1985 |
Stimulation by leumorphin of prolactin secretion from the pituitary in rats.
Topics: Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Male; Naloxone; Pituitary Gland, Anterior; Prolactin; Protein Precursors; Rats; Swine; Thyrotropin-Releasing Hormone | 1985 |
Selective presence of opiate receptors on intestinal circular muscle cells.
Topics: Acetylcholine; Animals; Atropine; Benzomorphans; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Humans; Jejunum; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Proglumide; Receptors, Opioid; Sincalide | 1985 |
Effects of opioid agonists and antagonists on oxytocin and vasopressin release in vitro.
Topics: Animals; Arginine Vasopressin; Benzomorphans; beta-Endorphin; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains | 1985 |
Somatostatin analogs with affinity for opiate receptors in rat brain binding assay.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Somatostatin; Structure-Activity Relationship | 1985 |
Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. I. Behavioral characterization.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Administration Schedule; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Microinjections; Motor Activity; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Tegmentum Mesencephali | 1985 |
Stereospecific opiate binding in living human polymorphonuclear leucocytes.
Topics: Analgesics, Opioid; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Granulocytes; Humans; Kinetics; Naloxone; Neutrophils; Receptors, Opioid | 1985 |
Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at mu- and kappa-opioid receptor sites in rabbit and guinea-pig cerebellum membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1985 |
Opioid binding in a rat neurohypophysial fraction enriched in oxytocin and vasopressin nerve endings.
Topics: Animals; Arginine Vasopressin; Binding Sites; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats | 1985 |
Epidural injections of bupivacaine, morphine, fentanyl, lofentanil, and DADL in chronically implanted rats: a pharmacologic and pathologic study.
Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Bupivacaine; Catheterization; Catheters, Indwelling; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epidural Space; Fentanyl; Male; Morphine; Motor Activity; Naloxone; Rats; Rats, Inbred Strains; Reaction Time; Time Factors | 1986 |
Presynaptic inhibitory opioid delta- and kappa-receptors in a branch of the rabbit ileocolic artery.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Female; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Naloxone; Norepinephrine; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vasoconstriction | 1985 |
Actions of opiate agonists, naloxone, and paraben preservatives in the rat lung circulation.
Topics: Angiotensin II; Animals; Dynorphins; Enkephalin, Leucine; Hypoxia; Male; Morphine; Naloxone; Potassium Chloride; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Characterization of opioid receptor subtypes in solution.
Topics: Animals; Brain; Cations; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Guanylyl Imidodiphosphate; Iodoacetamide; Kinetics; Magnesium; Naloxone; Rats; Receptors, Opioid; Sodium; Solutions | 1986 |
In-vitro study of the enkephalinergic hypothesis for non-adrenergic, non-cholinergic innervation in the cat stomach.
Topics: Animals; Atropine; Cats; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; In Vitro Techniques; Male; Morphine; Naloxone; Neurotransmitter Agents; Serotonin; Stomach; Synaptic Transmission | 1986 |
The effect of peptides on cerebrovascular resistance in cats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Cats; Cerebral Arteries; Enkephalins; Morphine; Naloxone; Neurotensin; Peptides; Receptors, Bradykinin; Receptors, Neurotransmitter; Receptors, Opioid; Vascular Resistance | 1985 |
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Presynaptic opioid receptors modulating acetylcholine release in the hippocampus of the rabbit.
Topics: Acetylcholine; Animals; Benzomorphans; Choline; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Naloxone; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique.
Topics: Analgesics, Opioid; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Medulla Oblongata; Morphine; Naloxone; Oligopeptides; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sufentanil | 1986 |
Enkephalin but not morphine modulates the motor activity in the frog spinal cord in vitro.
Topics: Animals; Dynorphins; Electric Stimulation; Electrophysiology; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Histocytochemistry; In Vitro Techniques; Morphine; Motor Activity; Naloxone; Rana catesbeiana; Reflex; Spinal Cord | 1986 |
Cyclic somatostatin octapeptide analogues with high affinity and selectivity toward mu opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, Somatostatin; Somatostatin; Structure-Activity Relationship | 1986 |
Effects of opioid peptides on immunoreactive corticotropin-releasing factor release from the rat hypothalamus in vitro.
Topics: Animals; Corticotropin-Releasing Hormone; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dynorphins; Endorphins; Enkephalins; Hypothalamus; In Vitro Techniques; Male; Naloxone; Radioimmunoassay; Rats; Secretory Rate | 1986 |
Study on the possible neurotransmitter of the non-adrenergic non-cholinergic innervation of the rat gastric fundus.
Topics: Adenosine Triphosphate; Animals; Autonomic Nervous System; Electric Stimulation; Enkephalins; Female; Gastric Fundus; In Vitro Techniques; Male; Naloxone; Neurotensin; Neurotransmitter Agents; Rats; Somatostatin; Synaptic Transmission; Vasoactive Intestinal Peptide | 1986 |
Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217.
Topics: Analgesics, Opioid; Animals; Carboxypeptidases; Carboxypeptidases A; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1986 |
Centrally-administered opioid selective agonists inhibit drinking in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Drinking Behavior; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid | 1986 |
Interactions of Tyr-MIF-1 at opiate receptor sites.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Binding characteristics of [3H]opioid ligands to active opioid binding sites solubilized from rat brain membranes by glycodeoxycholate and NaCl: the recovery of binding activity by dilution.
Topics: Animals; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Glycodeoxycholic Acid; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride; Solutions | 1987 |
[Frequency as the cardinal determinant for electroacupuncture analgesia to be reversed by opioid antagonists].
Topics: Acupuncture Therapy; Animals; beta-Endorphin; Dynorphins; Electric Stimulation Therapy; Endorphins; Enkephalins; Naloxone; Naltrexone; Pain; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
On the presence of opioid receptors in guinea-pig ventricular tissue.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Heart; Hydroxydopamines; In Vitro Techniques; Myocardium; Naloxone; Narcotics; Norepinephrine; Oxidopamine; Peptide Fragments; Protease Inhibitors; Receptors, Opioid; Sympathetic Nervous System | 1987 |
Antagonism of mu-opioid receptor-mediated inhibitions of nociceptive neurones by U50488H and dynorphin A1-13 in the rat dorsal horn.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Naloxone; Neural Inhibition; Nociceptors; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1987 |
Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Haloperidol; Histamine; Histidine Decarboxylase; Ketamine; Male; Methylhistidines; Mice; Naloxone; Pargyline; Phenazocine; Phencyclidine; Receptors, Opioid | 1987 |
Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Arthritis; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Morphine; Naloxone; Nociceptors; Pain; Peripheral Nerves; Pyrrolidines | 1987 |
In vitro studies of the effects of naloxone on the root potentials in the frog spinal cord: enkephalin-like effect on the recurrent presynaptic inhibition.
Topics: Animals; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Membrane Potentials; Naloxone; Rana catesbeiana; Receptors, Opioid; Reflex; Spinal Cord; Synapses; Synaptic Membranes | 1987 |
[Involvement of dynorphin in the antinociception induced by intrathecal injection of neurotensin in the rat].
Topics: Analgesia; Animals; Dynorphins; Enkephalins; Female; Immunoglobulin G; Injections, Spinal; Naloxone; Neurotensin; Protease Inhibitors; Rats | 1987 |
Dose- and strain-dependent effects of dermorphin and [D-Ala2-D-Leu5]enkephalin on passive avoidance behavior in mice.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Opioid; Species Specificity | 1985 |
Bilateral intranigral microinjection of morphine and opioid peptides produces antinociception in rats.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Microinjections; Morphine; Naloxone; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time; Substantia Nigra | 1987 |
Mu opioid antagonist properties of a cyclic somatostatin octapeptide in vivo: identification of mu receptor-related functions.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred ICR; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1987 |
Effect of neuropeptides on macrophage mediated cytotoxicity in normal donors and cancer patients.
Topics: alpha-Endorphin; Breast Neoplasms; Cell Line; Cytotoxicity, Immunologic; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hodgkin Disease; Humans; Macrophages; Naloxone; Neoplasms; Neuropeptides | 1987 |
Phelorphan, an inhibitor of enzymes involved in the biodegradation of enkephalins, affected the withdrawal symptoms in chronic morphine-dependent rats.
Topics: Aminopeptidases; Animals; Brain; CD13 Antigens; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Male; Morphine Dependence; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1987 |
Purification of a kappa-opioid receptor subtype from frog brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Chromatography, Gel; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Membranes; Molecular Weight; Naloxone; Peptide Fragments; Pyrrolidines; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa; Solubility | 1987 |
Synaptosomal free [Ca2+] is reduced by clonidine and dynorphin A-(1-13) and increased by idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Calcium; Clonidine; Dioxanes; Dioxins; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; In Vitro Techniques; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Synaptosomes | 1987 |
Mutual antagonism of kappa-opiate and alpha 2-adrenoceptor agonist effects on intrasynaptosomal free [Ca2+]i.
Topics: Aminoquinolines; Animals; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fluorescent Dyes; Idazoxan; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes | 1988 |
Mu-, delta-, kappa- and epsilon-opioid receptor modulation of the hypothalamic-pituitary-adrenocortical (HPA) axis: subchronic tolerance studies of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2: a potent and selective antagonist opioid receptors.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1986 |
Dynorphin A (1-13): in vivo opioid antagonist actions and non-opioid anticonvulsant effects in the rat flurothyl test.
Topics: Animals; Anticonvulsants; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Flurothyl; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Seizures | 1986 |
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
Topics: Animals; Autoradiography; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Membranes; Tomography, Emission-Computed | 1988 |
Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GABA Antagonists; Hippocampus; Interneurons; Naloxone; Oligopeptides; Rats; Receptors, Opioid | 1988 |
Analgesia and the blood-brain barrier transport system for Tyr-MIF-1/enkephalins: evidence for a dissociation.
Topics: Animals; Blood-Brain Barrier; Enkephalins; Food Deprivation; Male; Mice; Mice, Inbred ICR; Morphine; MSH Release-Inhibiting Hormone; Naloxone; Pain; Restraint, Physical; Stereoisomerism; Stress, Physiological; Time Factors; Water Deprivation | 1988 |
Differential sensitivity of opioid-induced feeding to naloxone and naloxonazine.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Eating; Electroshock; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains | 1988 |
Characterization of opioid receptors on isolated canine gallbladder smooth muscle cells.
Topics: Animals; Benzomorphans; Dogs; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gallbladder; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Receptors, Opioid | 1988 |
The effect of opiates upon prostatic carcinoma cell growth.
Topics: beta-Endorphin; Cell Division; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Male; Morphine; Naloxone; Narcotics; Prostatic Neoplasms; Receptors, Opioid; Tumor Cells, Cultured | 1988 |
Antinociceptive action of intracerebroventricularly administered dynorphin and other opioid peptides in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Cold Temperature; Drug Interactions; Dynorphins; Enkephalins; Injections, Intraventricular; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1988 |
Dynorphin A [1-17] induces "reward" in rats in the place conditioning paradigm.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Rats; Rats, Inbred Strains; Reward | 1988 |
Opiate binding in calf thalamic membranes: a selective mu 1 binding assay.
Topics: Animals; Cattle; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus | 1988 |
Peripheral sympatho-inhibitory cardiovascular effects of opioid peptides in anaesthetized rabbits.
Topics: Animals; Decerebrate State; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hemodynamics; Levallorphan; Male; Naloxone; Norepinephrine; Pentobarbital; Quaternary Ammonium Compounds; Rabbits; Sympathetic Nervous System | 1988 |
Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats.
Topics: Animals; Cats; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Narcotic Antagonists; Narcotics; Peptide Fragments; Stomach; Vagus Nerve | 1988 |
Effects of proenkephalin products on rat cardiac and vascular tissue in-vitro.
Topics: Animals; Enkephalins; Heart; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Naloxone; Norepinephrine; Perfusion; Protein Precursors; Rats; Rats, Inbred Strains | 1988 |
Regulation of human natural cytotoxicity by enkephalins and selective opiate agonists.
Topics: Adult; Cell Division; Cytotoxicity, Immunologic; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Humans; Killer Cells, Natural; Lymphocytes; Naloxone; Oligopeptides; Receptors, Opioid; T-Lymphocytes | 1988 |
Orally administered kappa but not mu opiate agonists enhance gastric emptying of a solid canned food meal in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Diuretics; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Opioid-mediated cardiovascular effects of clonidine in spontaneously hypertensive rats: elimination by neonatal treatment with monosodium glutamate.
Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Glutamates; Heart Rate; Hemodynamics; Hypertension; Medulla Oblongata; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Glutamate | 1986 |
Differential effect of posttraining naloxone, beta-endorphin, leu-enkephalin and electroconvulsive shock administration upon memory of an open-field habituation and of a water-finding task.
Topics: Animals; beta-Endorphin; Drinking Behavior; Electroshock; Endorphins; Enkephalin, Leucine; Female; Habituation, Psychophysiologic; Hypothalamus; Memory; Naloxone; Rats; Rats, Inbred Strains; Water Deprivation | 1986 |
Involvement of endogenous opiates in glucose-stimulated hyperinsulinism of canine endotoxin shock. Inhibition by naloxone.
Topics: Animals; beta-Endorphin; Blood Glucose; Dogs; Endorphins; Endotoxins; Enkephalin, Leucine; Enkephalin, Methionine; Escherichia coli; Glucose; Hyperinsulinism; Insulin; Kinetics; Male; Naloxone; Shock, Septic | 1987 |
Central nervous system actions of beta-endorphin on gastric acid secretion.
Topics: Animals; Autonomic Nervous System; beta-Endorphin; Brain; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gastric Acid; Injections, Intraventricular; Male; Naloxone; Pentagastrin; Vagus Nerve | 1987 |
Modulation by endogenous opioid peptides of the secretion of LHRH from cockerel (Gallus domesticus) mediobasal hypothalamic tissue.
Topics: Animals; beta-Endorphin; Chickens; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Naloxone | 1987 |
[Comparative effect of opioid receptor ligands on cell division in the epithelium of the tongue in white rats].
Topics: Animals; beta-Endorphin; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Rats; Tongue | 1987 |
The effect of enkephalins and of beta-endorphin on the hypertensive response to physostigmine in the rat.
Topics: Animals; beta-Endorphin; Blood Pressure; Catecholamines; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Physostigmine; Rats; Rats, Inbred Strains | 1987 |
Possible delta receptor mediation of the effect of beta-endorphin on luteinizing hormone (LH) release, but not on prolactin (PRL) release, in the ovariectomized rat.
Topics: Animals; beta-Endorphin; Castration; Endorphins; Enkephalin, Leucine; Female; Kinetics; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Melphalan potently substitutes the N-terminal Tyr of D-Ala2-Leu5-enkephalin methyl ester.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Melphalan; Naloxone; Rats; Receptors, Opioid | 1985 |
Opioid effects on plasma concentrations of luteinizing hormone and prolactin in the adult male rhesus monkey.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Macaca mulatta; Male; Morphine; Naloxone; Prolactin; Receptors, Opioid | 1985 |
Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms.
Topics: Analgesia; Animals; Blood Gas Analysis; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Respiration | 1985 |
TENA, a selective kappa opioid receptor antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
delta-Opioid modulation of striatal dopaminergic activity in mice.
Topics: Animals; Corpus Striatum; Dopamine; Enkephalin, Leucine; Male; Mice; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptic Transmission | 1985 |
Modulation of cholinergic neurotransmission in airways by enkephalin.
Topics: Acetylcholine; Animals; Depression, Chemical; Dogs; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Propranolol; Receptors, Opioid; Synaptic Transmission; Trachea | 1985 |
Differentiating aspects of opioid receptor binding by [3H](-) (1R,5R,9R,2''S)-5,9-dimethyl-2-tetrahydrofurfuryl-2'-hydroxy-6,7- benzomorphan hydrochloride ([3H]Mr 2034), a drug preferentially acting on kappa-receptors.
Topics: Animals; Benzomorphans; Binding, Competitive; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure.
Topics: Animals; Anticonvulsants; Electroshock; Enkephalin, Leucine; Male; Naloxone; Narcotic Antagonists; Peptide Hydrolases; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures | 1985 |
[Selectivity of [D-Ala2-O-benzyl-Ser5]-enkephalin on mu and delta opiate receptor subtypes].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Detection and characterization of four binding sites for opioids in the mouse brain.
Topics: Animals; Binding Sites; Brain Chemistry; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Models, Biological; Naloxone; Receptors, Opioid; Software; Tritium | 1985 |
Selective attenuation of sweetened milk consumption by opiate receptor antagonists in male and female rats of the Roman strains.
Topics: Animals; Appetite Depressants; Azocines; Benzomorphans; Diprenorphine; Enkephalin, Leucine; Feeding Behavior; Female; Male; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid; Sex Factors; Species Specificity | 1985 |
Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Discrimination, Psychological; Drug Synergism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Fluoxetine; Male; Morphine; Naloxone; Pain; Propylamines; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin | 1985 |
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment.
Topics: Animals; Binding, Competitive; Brain; Drug Implants; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Time Factors | 1985 |
Rabbit anti-idiotypic antibodies raised against monoclonal anti-morphine IgG block mu & delta opiate receptor sites.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Guinea Pigs; Immune Sera; Immunoglobulin G; Immunoglobulin Idiotypes; Mice; Morphine; Naloxone; Rabbits; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Mainly mu-opiate receptors are involved in luteinizing hormone and prolactin secretion.
Topics: Animals; Animals, Suckling; Benzomorphans; Castration; Enkephalin, Leucine; Estradiol; Female; Luteinizing Hormone; Male; Naloxone; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation | 1985 |
Effect of [D-Ala2,Met5]enkephalinamide and [D-Ala2,D-Leu5]enkephalin on cholinergic and noradrenergic neurotransmission in isolated atria.
Topics: Acetylcholine; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Naloxone; Norepinephrine; Rabbits; Rats; Synaptic Transmission; Tetrodotoxin | 1985 |
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1985 |
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Hybrid Cells; Kinetics; Ligands; Morphine; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Central delta-opioid receptor interactions and the inhibition of reflex urinary bladder contractions in the rat.
Topics: Animals; beta-Endorphin; Central Nervous System; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalins; Female; Injections, Intraventricular; Injections, Spinal; Muscle Contraction; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1985 |
Immunoregulation by opioid peptides: I. Absence of classical opioid receptor on human mononuclear cells.
Topics: B-Lymphocytes; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Ligands; Monocytes; Naloxone; Receptors, Opioid; T-Lymphocytes | 1985 |
Enkephalins have a direct positive inotropic effect on cultured cardiac myocytes.
Topics: Animals; Brain; Calcium; Chick Embryo; Enkephalins; Isoproterenol; Myocardial Contraction; Myocardium; Naloxone; Propranolol; Receptors, Opioid | 1985 |
Neurohypophysial opioids and oxytocin secretion: source of inhibitory opioids.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalin, Leucine; Female; Lactation; Naloxone; Neural Inhibition; Oxytocin; Pituitary Gland, Posterior; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, delta; Supraoptic Nucleus | 1985 |
Multiple opiate receptors: functional implications.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Azocines; Behavior, Animal; Binding Sites; Blood Pressure; Clonidine; Corticosterone; Enkephalins; Naloxone; Receptors, Opioid; Stress, Physiological; Sympathetic Nervous System | 1985 |
Gamma-aminobutyric acid and benzodiazepine receptor changes induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle.
Topics: Animals; Autoradiography; Benzodiazepines; Brain; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Flunitrazepam; Hydroxydopamines; Kinetics; Muscimol; Naloxone; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spiperone; Tritium | 1985 |
Leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to the opiate mu-recognition site: evidence for delta----mu binding site interactions in vitro.
Topics: Animals; Bacitracin; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Combined autoradiographic-immunocytochemical analysis of opioid receptors and opioid peptide neuronal systems in brain.
Topics: Animals; Autoradiography; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Histocytochemistry; Male; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tissue Distribution; Tritium | 1985 |
Regulation of ventilation and oxygen consumption by delta- and mu-opioid receptor agonists.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Naloxone; Oxygen; Oxygen Consumption; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
The effect of opioids and of naloxone on Na+,K+-adenosine triphosphatase activity in frog spinal cord membrane fractions.
Topics: Animals; Captopril; Cell Membrane; Endorphins; Enkephalins; Glycopeptides; Morphine; Naloxone; Rana temporaria; Sodium-Potassium-Exchanging ATPase; Spinal Cord | 1985 |
Thymus peptides interacting with opiate receptors.
Topics: Animals; Brain; Enkephalins; Hemoglobins; Male; Morphine; Naloxone; Peptides; Proteins; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Thymus Gland | 1985 |
A monoclonal antibody capable of modulating opioid binding to rat neural membranes.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cyclazocine; Dihydromorphine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Flunitrazepam; Immunoglobulin M; Kinetics; Male; Mice; Mice, Inbred BALB C; Molecular Weight; Naloxone; Narcotics; Nerve Tissue; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Temperature responses in restrained and unrestrained rats to the selective mu opioid agonist, DAGO.
Topics: Animals; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Restraint, Physical; Stress, Physiological | 1985 |
Comparison of mu opioid agonists in vitro.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naloxone; Receptors, Opioid; Receptors, Opioid, mu | 1985 |
beta-Endorphin and enkephalins stimulate duodenal mucosal alkaline secretion in the rat in vivo.
Topics: Animals; beta-Endorphin; Bicarbonates; Duodenum; Endorphins; Enkephalins; Intestinal Mucosa; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Stimulation, Chemical | 1986 |
Proenkephalin A fragments exhibit spinal and supraspinal opioid activity in vivo.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Muscle Contraction; Naloxone; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Urinary Bladder | 1985 |
Leu-enkephalin actions on avoidance conditioning are mediated by a peripheral opioid mechanism.
Topics: Animals; Avoidance Learning; Enkephalin, Leucine; Immune Sera; Immunization, Passive; Male; Mice; Naloxone; Quaternary Ammonium Compounds; Receptors, Opioid | 1985 |
Characterisation of the delta-opioid receptor on the hamster vas deferens.
Topics: Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Mesocricetus; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1985 |
[Cerebrovascular effects of met- and leu-enkephalins].
Topics: Animals; Blood Pressure; Cats; Cerebrovascular Circulation; Enkephalin, Leucine; Enkephalin, Methionine; Naloxone; Rabbits; Receptors, Opioid; Reflex; Sympathetic Nervous System; Vasoconstriction | 1986 |
A human neuroblastoma cell line expresses mu and delta opioid receptor sites.
Topics: Bone Neoplasms; Cell Line; Child, Preschool; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Guanylyl Imidodiphosphate; Humans; Kinetics; Naloxone; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Role of endogenous opiates and extracellular K+ accumulation in the inhibition of frog spinal reflexes by electrical skin stimulation.
Topics: Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Extracellular Space; Hindlimb; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Neural Inhibition; Neurons, Afferent; Potassium; Rana temporaria; Reflex; Skin Physiological Phenomena; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1985 |
Neostriatal projections from individual cortical fields conform to histochemically distinct striatal compartments in the rat.
Topics: Animals; Autoradiography; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gyrus Cinguli; Male; Naloxone; Neural Pathways; Rats; Receptors, Opioid | 1986 |
New pharmacologic approaches to spinal cord injury: opiate antagonists and thyrotropin-releasing hormone.
Topics: Animals; Azocines; Cats; Endorphins; Enkephalin, Leucine; Humans; Naloxone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Spinal Cord Injuries; Thiazolidines; Thyrotropin-Releasing Hormone | 1985 |
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Diprenorphine; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Etorphine; Glioma; Hybridomas; Naloxone; Neuroblastoma; Phenylisopropyladenosine; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Transcription, Genetic | 1986 |
Involvement of different receptor subtypes for the production of in vitro and in vivo effects in a series of synthetic enkephalin analogues.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Time Factors | 1985 |
Classification of presynaptic opioid receptors in the rabbit ear artery by competitive antagonists.
Topics: Animals; Arteries; Benzomorphans; Binding, Competitive; Biological Assay; Cyclazocine; Ear; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Naloxone; Rabbits; Receptors, Opioid; Synaptic Membranes | 1986 |
Intrathecal D-Ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate.
Topics: Aged; Carcinoma; Clonidine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Injections, Spinal; Male; Morphine; Naloxone; Pain, Intractable; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Skull Neoplasms; Spinal Neoplasms; Substance Withdrawal Syndrome; Thyroid Neoplasms | 1986 |
Central opioid receptors and baroreflex control of sympathetic and cardiovascular function.
Topics: Animals; Blood Pressure; Brain; Cardiovascular Physiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Heart Rate; Naloxone; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Sympathetic Nervous System | 1986 |
Interaction of enkephalins and des-tyrosyl-enkephalins with synaptosomal plasma membrane vesicles: enkephalin binding and inhibition of proline transport.
Topics: Amino Acids; Animals; Biological Transport; Cell Membrane; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kinetics; Naloxone; Proline; Receptors, Opioid; Structure-Activity Relationship; Synaptosomes | 1986 |
Is there a common, high-affinity opioid binding site in rat brain?
Topics: Animals; Binding, Competitive; Brain Chemistry; Buprenorphine; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Pentazocine; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): evidence from binding assays.
Topics: Animals; Binding, Competitive; Brain; Chromatography, Gel; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Kinetics; Male; Naloxone; Phenazocine; Phencyclidine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Behavioral specificity of beta-endorphin suppression of sexual behavior: differential receptor antagonism.
Topics: Animals; Behavior, Animal; beta-Endorphin; Endorphins; Enkephalin, Leucine; Estrogens; Female; Naloxone; Narcotic Antagonists; Ovariectomy; Progesterone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sexual Behavior, Animal | 1986 |
The in vitro and in vivo effects of enkephalins and beta-endorphin on ACE activity in mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; beta-Endorphin; Brain; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Lung; Mice; Mice, Inbred Strains; Naloxone; Peptidyl-Dipeptidase A | 1986 |
[Participation of the endogenous opioid system in the formation of the body's response to stress].
Topics: Animals; Blood Pressure; Electroshock; Enkephalins; Hypothalamus; Macaca mulatta; Medulla Oblongata; Morphine; Naloxone; Papio; Receptors, Opioid; Restraint, Physical; Stress, Psychological | 1986 |
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1986 |
Mu receptors at discrete hypothalamic and brainstem sites mediate opioid peptide-induced increases in central sympathetic outflow.
Topics: Animals; beta-Endorphin; Brain Stem; Catecholamines; Cerebral Cortex; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sympathetic Nervous System; Trigeminal Nucleus, Spinal | 1986 |
Blockade of D-2 dopamine receptors strongly enhances the potency of enkephalins to inhibit dopamine-sensitive adenylate cyclase in rat neostriatum: involvement of delta- and mu-opioid receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclase Inhibitors; Animals; Benzazepines; Corpus Striatum; Cyclic AMP; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ergolines; Male; Morphine; Naloxone; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Action at the mu receptor is sufficient to explain the supraspinal analgesic effect of opiates.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Protein Precursors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1986 |
Studies of kappa agonist.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Humans; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Modulation of cholinergic transmission by opiate peptide and FMRFamide on identified neurons of Helix pomatia L. (Gastropoda, Mollusca).
Topics: Animals; Cholinergic Fibers; Enkephalin, Leucine; FMRFamide; Helix, Snails; Morphine; Naloxone; Oligopeptides; Synaptic Transmission | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: studies with receptor selective agonists.
Topics: Analgesia; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Spinal Cord | 1986 |
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1986 |
Studies on the mesolimbic loop of antinociception--II. A serotonin-enkephalin interaction in the nucleus accumbens.
Topics: Animals; Brain Mapping; Enkephalins; Morphine; Naloxone; Neural Pathways; Nucleus Accumbens; Pain; Periaqueductal Gray; Rabbits; Septal Nuclei; Serotonin; Synaptic Transmission | 1986 |
[Studies on the content and effects of opiate-like substances in rabbit ear artery strips].
Topics: Animals; Arteries; Biological Assay; Ear; Endorphins; Enkephalin, Leucine; Female; In Vitro Techniques; Male; Naloxone; Pronase; Rabbits; Radioimmunoassay; Receptors, Opioid | 1986 |
Synthesis of four diastereomeric enkephalins incorporating cyclopropyl phenylalanine.
Topics: Animals; Binding, Competitive; Brain; Circular Dichroism; Cyclopropanes; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Male; Naloxone; Phenylalanine; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 1986 |
Effects of mu-opioid receptor stimulation in the hypothalamic paraventricular nucleus on basal and stress-induced catecholamine secretion and cardiovascular responses.
Topics: Animals; Blood Pressure; Cardiovascular System; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Heart Rate; Male; Microinjections; Naloxone; Norepinephrine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Restraint, Physical; Stress, Physiological | 1986 |
Interaction of [D-Ser2,Leu5]enkephalin-Thr6 (DSLET), a relatively selective delta ligand, with mu1 opioid binding sites.
Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Male; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Increased food intake after opioid microinjections into nucleus accumbens and ventral tegmental area of rat.
Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Enkephalin, Methionine; Enkephalins; Feeding Behavior; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei; Tegmentum Mesencephali | 1986 |
Differential depressive action of two mu and delta opioid ligands on neuronal responses to noxious stimuli in the thalamic ventrobasal complex of rat.
Topics: Action Potentials; Animals; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hot Temperature; Male; Naloxone; Neurons; Oligopeptides; Pain; Physical Stimulation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus | 1986 |
Naloxazone treatment in the guinea pig ileum in vitro reveals second functional opioid receptor site.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Male; Mathematics; Naloxone; Receptors, Opioid; Time Factors | 1987 |
Continuous intrathecal opioid analgesia: tolerance and cross-tolerance of mu and delta spinal opioid receptors.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1987 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Audiogenic seizures during ethanol withdrawal can be blocked by a delta opioid agonist.
Topics: Acoustic Stimulation; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethanol; Female; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome | 1986 |
Postmortem changes in rat brain: studies on membrane-bound enzymes and receptors.
Topics: Animals; Brain; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Cell Membrane; Diazepam; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Male; Naloxone; Postmortem Changes; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Receptors, Opioid; Sodium-Potassium-Exchanging ATPase; Succinates | 1987 |
Proglumide exhibits delta opioid agonist properties.
Topics: Animals; Binding, Competitive; Electric Stimulation; Enkephalin, Leucine; Enzyme Inhibitors; Glutamine; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naloxone; Norepinephrine; Proglumide; Receptors, Opioid; Receptors, Opioid, delta; Synaptosomes | 1987 |
Opioid enhancement of perforant path transmission: effect of an enkephalin analog on inhibition and facilitation in the dentate gyrus.
Topics: Action Potentials; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hippocampus; Male; Naloxone; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptic Transmission | 1986 |
Naloxonazine and opioid-induced inhibition of reflex urinary bladder contractions.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Muscle Contraction; Naloxone; Rats; Receptors, Opioid; Reflex; Urinary Bladder | 1987 |
Increased responsiveness to glucoregulatory effect of opiates in obese-diabetic ob/ob mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enkephalins; Insulin; Mice; Mice, Obese; Naloxone; Receptors, Opioid | 1987 |
Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Motor Activity; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tegmentum Mesencephali | 1987 |
Modulation of rat brain opioid receptors by cannabinoids.
Topics: Animals; Cannabinoids; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spiperone | 1987 |
Inhibition of dopamine-sensitive adenylate cyclase by opioids: possible involvement of physically associated mu- and delta-opioid receptors.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Corpus Striatum; Cyclic AMP; Dopamine Antagonists; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Isoproterenol; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vasoactive Intestinal Peptide | 1987 |
Angiotensin III: a potent inhibitor of enkephalin-degrading enzymes and an analgesic agent.
Topics: Acetylcholinesterase; Aminopeptidases; Analgesics; Angiotensin II; Angiotensin III; Angiotensin-Converting Enzyme Inhibitors; Animals; Cell Membrane; Cholinesterase Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Kidney; Mice; Mice, Inbred ICR; Naloxone; Neprilysin; Protease Inhibitors | 1987 |
Actions of opioids on the dorsal root potential of the isolated spinal cord preparation of the neonate rat.
Topics: Animals; Animals, Newborn; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Spinal Nerve Roots | 1987 |
The contributions of mu-, delta- and kappa-opioid receptors to the actions of endogenous opioids on spinal reflexes in the rabbit.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalin, Leucine; Hemodynamics; Naloxone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1987 |
Naloxonazine effects on the interaction of enkephalin analogs with mu-1, mu and delta opioid binding sites in rat brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Leucine-enkephalin as a modulator of neurotransmission in cat lower esophageal sphincter.
Topics: Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Esophagogastric Junction; Morphine; Muscle Contraction; Naloxone; Synaptic Transmission | 1987 |
[Effect of the opiate antagonist naloxone on the electrical activity of identified neurons in the edible snail].
Topics: Animals; Benzomorphans; beta-Endorphin; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Helix, Snails; Membrane Potentials; Morphine; Naloxone; Neurons; Receptors, Opioid | 1987 |
[Alpha interferon interaction with opiate receptors in the rat brain].
Topics: Animals; Bacitracin; Brain; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Interferon Type I; Naloxone; Protein Binding; Rats; Receptors, Opioid; Tritium | 1987 |
[Opioid activity of peptides and wound healing of the skin].
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Skin; Wound Healing | 1987 |
Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Naloxone; Protein Precursors; Radioligand Assay; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hippocampus; In Vitro Techniques; Male; Naloxone; Rats; Rats, Inbred Strains | 1988 |
Effect of intravenous enkephalin administration on kallikrein-kinin system in experimental hemorrhagic shock. Evidence for activation of kallikrein-kinin system by naloxone.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemorrhage; Injections, Intravenous; Kallikreins; Kinins; Male; Naloxone; Rats; Rats, Inbred Strains; Shock, Hemorrhagic | 1988 |
Possible mediation of catecholaminergic pathways in the antinociceptive effect of an extract of Cannabis sativa L.
Topics: Analgesics; Animals; Benzomorphans; Cannabis; Dose-Response Relationship, Drug; Enkephalin, Leucine; Haplorhini; Hydroxydopamines; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oxidopamine; Plant Extracts; Rats; Rats, Inbred Strains | 1986 |
Cardiorespiratory effects and kinetics of intrathecally injected D-Ala2-D-Leu5-enkephalin and morphine in unanesthetized dogs.
Topics: Animals; Behavior, Animal; Carbon Dioxide; Cardiovascular System; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Spinal; Kinetics; Male; Morphine; Naloxone; Respiration | 1986 |
Effect of parasympathetic blockade on ventilatory and cardiac depression induced by opioids.
Topics: Animals; Arteries; Atropine; Carbon Dioxide; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart; Heart Rate; Naloxone; Nerve Block; Parasympathetic Nervous System; Partial Pressure; Respiration | 1987 |
Role of endogenous enkephalins in locomotion evidenced by acetorphan, an "enkephalinase" inhibitor.
Topics: Amino Acids, Sulfur; Animals; Dose-Response Relationship, Drug; Enkephalins; Hydroxydopamines; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thiorphan; Tiopronin | 1987 |
[Influence of electroacupuncture and antagonism of electroacupuncture analgesia by naloxone on enkephalin-like immunoreactivity in guinea pig's adrenal and spinal cord].
Topics: Acupuncture Therapy; Adrenal Glands; Analgesia; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Immunohistochemistry; Male; Naloxone; Pain; Sensory Thresholds; Spinal Cord | 1988 |
Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances.
Topics: Analgesics; Animals; Carrageenan; Clonidine; Dinoprostone; Drug Tolerance; Enkephalins; Male; Morphine; Naloxone; Peripheral Nerves; Prostaglandins E; Rats; Rats, Inbred Strains; Yohimbine | 1988 |
N-allylnormetazocine: hemodynamic actions and inhibition of leucine-enkephalin hemodynamic activity in conscious dogs.
Topics: Animals; Blood Pressure; Dogs; Enkephalin, Leucine; Female; Heart Rate; Hemodynamics; Male; Naloxone; Phenazocine; Stereoisomerism | 1988 |
Opioid modulation of vasopressin secretion in conscious rats.
Topics: Animals; Blood Pressure; Carbachol; Endorphins; Enkephalins; Heart Rate; Male; Naloxone; Nicotine; Protein Precursors; Rats; Rats, Inbred Strains; Vasopressins | 1988 |
Effects of opiate agonists and antagonists on aggressive encounters and subsequent opioid-induced analgesia, activity and feeding responses in male mice.
Topics: Aggression; Agonistic Behavior; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Feeding Behavior; Homing Behavior; Injections, Intramuscular; Levorphanol; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics | 1988 |
Effects of [D-Ala2-O-benzyl-Ser5]-enkephalin on CA1 field potentials in rat hippocampal slices.
Topics: Animals; Electrophysiology; Enkephalins; Hippocampus; In Vitro Techniques; Naloxone; Rats | 1988 |
Effects of opioid peptides on aldosterone production: stimulatory effect of leu-enkephalin.
Topics: Adrenal Cortex; Aldosterone; Animals; Cattle; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Perfusion | 1988 |
[Effect of opioid peptides on the lymphatic drainage of the pancreas in the rat and dog].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Evans Blue; Female; Lymph; Male; Naloxone; Pancreas; Phenazocine; Rats; Rats, Inbred Strains | 1988 |
Interaction between opioid agonists or naloxone and 5-HTP on feeding behavior in food-deprived rats.
Topics: 5-Hydroxytryptophan; Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Feeding Behavior; Food Deprivation; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains | 1988 |
Attenuation of endogenous opioid peptide inhibition of [Gln8]luteinizing hormone-releasing hormone secretion during sexual maturation in the cockerel.
Topics: Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Male; Naloxone; Oligopeptides; Pyrrolidonecarboxylic Acid; Sexual Maturation; Testosterone | 1988 |
Convulsant action of morphine, [D-Ala2, D-Leu5]-enkephalin and naloxone in the rat amygdala: electroencephalographic, morphological and behavioural sequelae.
Topics: Amygdala; Animals; Brain; Convulsants; Diazepam; Drug Interactions; Electroencephalography; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Microinjections; Morphine; Naloxone; Rats; Rats, Inbred Strains | 1987 |
Enkephalin uptake into cholinergic synaptic vesicles and nerve terminals.
Topics: Acetylcholine; Animals; Electric Organ; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Morphine; Naloxone; Nerve Endings; Synaptic Vesicles; Synaptosomes; Torpedo | 1987 |
[Participation of leu-enkephalin in regulating carbohydrate metabolism].
Topics: Animals; Blood Glucose; C-Peptide; Carbohydrate Metabolism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Insulin; Liver Glycogen; Male; Naloxone; Parathyroid Hormone; Rats | 1987 |
[Influence of captopril on the in vitro and in vivo effects of leu- and met-enkephalins].
Topics: Animals; Captopril; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Enkephalin, Leucine; Enkephalin, Methionine; Female; Guinea Pigs; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Pain; Time Factors | 1987 |
Enkephalins and immunity. I: In vivo suppression and potentiation of humoral immune response.
Topics: Adjuvants, Immunologic; Anaphylaxis; Animals; Antibody Formation; Enkephalin, Leucine; Enkephalin, Methionine; Hemolytic Plaque Technique; Immunosuppression Therapy; Male; Mice; Mice, Inbred BALB C; Naloxone; Rats; Rats, Inbred Strains | 1987 |
Naloxone increases mucosal fluid secretion in the inflamed and distended feline gall bladder: evidence for a possible protective mechanism by endogenous opioids.
Topics: Animals; Body Fluids; Cats; Cholecystitis; Endorphins; Enkephalins; Gallbladder; Hydrostatic Pressure; Mucous Membrane; Naloxone | 1988 |
Inhibitory action of leumorphin on vasopressin secretion in conscious rats.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Brain; Carbachol; Dehydration; Enkephalins; Injections, Intraventricular; Male; Naloxone; Protein Precursors; Rats; Rats, Inbred Strains | 1988 |
Implication of leumorphin in inhibitory control of vasopressin secretion in conscious rats.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Consciousness; Enkephalins; Male; Naloxone; Protein Precursors; Rats | 1988 |
Tissue content of opioid peptides in the myenteric plexus-longitudinal muscle of guinea-pig small intestine.
Topics: Animals; Biological Assay; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Intestine, Small; Male; Mice; Muscle Contraction; Myenteric Plexus; Naloxone; Protein Precursors; Tissue Distribution; Vas Deferens | 1988 |
[Delayed antihypoxic effect of leu enkephalin in mice].
Topics: Animals; Enkephalin, Leucine; Hypoxia; Male; Mice; Morphine; Naloxone; Time Factors | 1988 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Contraversive circling induced by ventral tegmental microinjections of moderate doses of morphine and [D-Pen2, D-Pen5]enkephalin.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Morphine; Naloxone; Rats; Stereotyped Behavior; Tegmentum Mesencephali; Time Factors | 1988 |
[Reduction of the rate of mitochondrial respiration in the rat heart perfused with opioids and naloxone].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Male; Mitochondria, Heart; Morphine; Naloxone; Oxygen Consumption; Perfusion; Rats; Rats, Inbred Strains | 1988 |
Opposite effects of kappa-opioid agonists on gastric emptying of liquids and solids in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Injections, Intravenous; Morphinans; Morphine; Naloxone; Pyrrolidines | 1988 |
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility).
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin | 1988 |
Effects of bestatin and phosphoramidon on the hypertensive response to physostigmine in the rat.
Topics: Animals; Antibiotics, Antineoplastic; Blood Pressure; Carotid Arteries; Catecholamines; Enkephalin, Leucine; Female; Glycopeptides; Injections, Intra-Arterial; Leucine; Male; Naloxone; Physostigmine; Rats; Rats, Inbred Strains | 1987 |
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1987 |
Influence of opiates on alkali secretion by amphibian gastric and duodenal mucosa in vitro.
Topics: Alkalies; Animals; Duodenum; Enkephalin, Leucine; Enkephalin, Methionine; Gastric Acid; Gastric Mucosa; Intestinal Mucosa; Morphine; Naloxone; Narcotics; Rana catesbeiana; Rana temporaria; Stimulation, Chemical | 1986 |
Effects of enkephalin, applied intracellularly, on action potentials in vertebrate A and C nerve fibre axons.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; In Vitro Techniques; Naloxone; Nerve Fibers; Nerve Fibers, Myelinated; Rabbits; Rana pipiens; Sciatic Nerve; Vagus Nerve | 1987 |
Effect of insulin on secretion of bombesin-like immunoreactivity and gastrin from the isolated rat stomach in response to acetylcholine, VIP and leucine-enkephalin.
Topics: Acetylcholine; Animals; Bombesin; Drug Interactions; Enkephalin, Leucine; Gastric Mucosa; Gastrins; Insulin; Naloxone; Rats; Vasoactive Intestinal Peptide | 1986 |
Do opioid peptides modulate, at the level of the nerve endings, the release of neurohypophysial hormones?
Topics: Animals; Biomechanical Phenomena; Calcium; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dopamine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Naloxone; Nerve Endings; Oxytocin; Pituitary Gland, Posterior; Potassium; Rats; Rats, Inbred Strains; Stimulation, Chemical; Vasopressins | 1986 |
Effect of captopril on blood pressure responses to enkephalins in chloralose-anaesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Captopril; Chloralose; Enkephalins; Heart Rate; Hydralazine; Male; Naloxone; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Effect of endorphins on heart rate and blood pressure in adult dogs.
Topics: Animals; Atropine; Blood Pressure; Consciousness; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; Heart Rate; Naloxone; Naltrexone | 1986 |
Do enkephalins participate in vagal activation of gastric acid secretion in man?
Topics: Adult; Duodenal Ulcer; Enkephalins; Gastric Juice; Gastrin-Releasing Peptide; Gastrins; Humans; Male; Middle Aged; Naloxone; Peptides; Pyrrolidines; Stomach; Vagus Nerve | 1987 |
Evidence for opioid and non-opioid forms of stress-induced analgesia in the snail, Cepaea nemoralis.
Topics: Animals; Cold Temperature; Endorphins; Enkephalin, Leucine; Hot Temperature; Naloxone; Naltrexone; Pain; Reaction Time; Snails; Stress, Physiological | 1987 |
[Effects of morphine and endogenous opioids on mechanical activity of isolated and perfused rat hearts ].
Topics: Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Heart Rate; In Vitro Techniques; Morphine; Naloxone; Perfusion; Rats; Rats, Inbred Strains; Sarcolemma | 1987 |
Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain.
Topics: Bacitracin; Blood-Brain Barrier; Brain; Caudate Nucleus; Enkephalin, Leucine; Female; Hippocampus; Kinetics; Male; Naloxone; Parietal Lobe; Tyrosine | 1987 |
Naloxone efficacy in bladder rehabilitation of spinal cord injury patients.
Topics: Adult; Aged; Electromyography; Enkephalins; Humans; Male; Middle Aged; Naloxone; Pressure; Spinal Cord Injuries; Urinary Bladder; Urinary Bladder, Neurogenic; Urinary Catheterization; Urodynamics | 1987 |
[Effect of opioid receptor ligands on cell division processes in the corneal epithelium of the white rat].
Topics: Animals; Cell Division; Cornea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epithelium; Male; Naloxone; Rats | 1987 |
Sex and day-night differences in opiate-induced responses of insular wild deer mice, Peromyscus maniculatus triangularis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Circadian Rhythm; Enkephalin, Leucine; Feeding Behavior; Female; Male; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Pain; Peromyscus; Pyrrolidines; Sex Characteristics | 1987 |
[Features of the action of opioid peptides and naloxone on the tissues of the central and peripheral nervous system during cultivation].
Topics: Animals; Culture Techniques; Drug Interactions; Embryo, Mammalian; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Naloxone; Organ Specificity; Rats; Rats, Inbred Strains; Spinal Cord | 1986 |
Effects of two enkephalin analogues, morphine sulphate, dopamine and naloxone on prolactin secretion from rat anterior pituitary glands in vitro.
Topics: Animals; Depression, Chemical; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Female; Morphine; Naloxone; Narcotics; Organ Culture Techniques; Perfusion; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Effects of superfusion of morphine and enkephalins on the activity of single units in the spinal trigeminal nucleus and cuneate nucleus of cat.
Topics: Action Potentials; Animals; Cats; Electrophysiology; Enkephalin, Methionine; Enkephalins; Female; Male; Medulla Oblongata; Morphine; Naloxone; Trigeminal Nucleus, Spinal | 1986 |
Actions of morphine and enkephalins on the internal anal sphincter of the cat: relevance for the physiological role of opiates.
Topics: Action Potentials; Anal Canal; Animals; Axons; Cats; Electric Stimulation; Electromyography; Enkephalins; Female; Hypogastric Plexus; Male; Morphine; Muscle, Smooth; Naloxone | 1986 |
Antinociceptive action of picrotoxin in the mouse.
Topics: Analgesics; Animals; Atropine; Enkephalins; GABA Antagonists; gamma-Aminobutyric Acid; Male; Methysergide; Mice; Naloxone; Picrotoxin | 1986 |
Modification of place preference conditioning in mice by systemically administered [Leu]enkephalin.
Topics: Animals; Choice Behavior; Conditioning, Psychological; Enkephalin, Leucine; Injections, Intraperitoneal; Male; Mice; Naloxone; Quaternary Ammonium Compounds | 1986 |
Pressor effects of systemic administration of methionine and leucine enkephalin in the conscious rat.
Topics: Animals; Atropine; Blood Pressure; Diprenorphine; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guanethidine; Heart Rate; Naloxone; Norepinephrine; Phentolamine; Propranolol; Rats | 1986 |
Antiopioid activity of the cardioexcitatory peptide in central modulation of cardiovascular functions.
Topics: Animals; Blood Pressure; Cardiovascular System; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; FMRFamide; Heart Rate; Injections, Intraventricular; Male; Naloxone; Nerve Tissue Proteins; Rats; Shock, Hemorrhagic | 1986 |
Potent action of leumorphin on consummatory behaviors in rats: comparison with other opioid peptides.
Topics: Angiotensin II; Animals; Carbachol; Drinking Behavior; Endorphins; Enkephalins; Feeding Behavior; Injections, Intraventricular; Male; Motor Activity; Naloxone; Protein Precursors; Rats; Rats, Inbred Strains | 1986 |
Effects of centrally administered naloxone on gastrointestinal myoelectrical activity in morphine-dependent rats.
Topics: Animals; Atropine; Clonidine; Digestive System; Electrophysiology; Enkephalin, Leucine; Gastrointestinal Motility; Indomethacin; Injections, Intraventricular; Injections, Subcutaneous; Male; Methysergide; Morphine; Naloxone; Phentolamine; Rats; Substance-Related Disorders; Tolazoline | 1987 |
Effect of enkephalins on colonic mechanoreceptor synaptic input to inferior mesenteric ganglion.
Topics: Animals; Colon; Enkephalin, Leucine; Evoked Potentials; Ganglia, Autonomic; Guinea Pigs; In Vitro Techniques; Mechanoreceptors; Naloxone; Neurons; Synapses | 1987 |
Action of enkephalinergic neurons on the gastrointestinal motility.
Topics: Animals; Digestive System Physiological Phenomena; Electric Stimulation; Enkephalins; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Neurons; Peristalsis; Vagus Nerve | 1985 |
The effects of selective opioid delta-receptor antagonists on stress-induced antinociception and plasma corticosterone levels in mice.
Topics: Analgesia; Animals; Enkephalin, Leucine; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pituitary-Adrenal System; Stress, Physiological | 1985 |
Opiate modulation of glucose turnover in dogs.
Topics: Animals; Blood Glucose; Dogs; Enkephalins; Female; Glucagon; Glucose; Hydrocortisone; Insulin; Naloxone; Narcotics; Time Factors | 1985 |
Effect of opiates on the release of cholecystokinin from in vitro hypothalamus and frontal cortex of Zucker lean (Fa/-) and obese (fa/fa) rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Hypothalamus; Morphine; Naloxone; Obesity; Potassium; Rats; Rats, Zucker; Sincalide | 1985 |
Locomotor activity of rats after injection of various opioids into the nucleus accumbens and the septum mediale.
Topics: Animals; Benzomorphans; Drug Synergism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections; Male; Morphine; Motor Activity; Naloxone; Narcotics; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Septum Pellucidum | 1985 |
Differential respiratory patterns induced by opioids applied to the ventral medullary and dorsal pontine surfaces of cats.
Topics: Animals; Carbon Dioxide; Cats; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Male; Medulla Oblongata; Morphine; Naloxone; Narcotics; Pons; Respiration; Tidal Volume; Time Factors | 1985 |
Molecular mechanisms of opiate tolerance and dependence in a clonal cell line.
Topics: Adenosine; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Naloxone; Narcotics; Nerve Tissue Proteins; Substance-Related Disorders | 1985 |
Non-opiate and peripheral-opiate cardiovascular effects of morphine in conscious dogs.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Dogs; Enkephalin, Leucine; Female; Heart Rate; Kinetics; Male; Morphine; Naloxone; Oxymorphone | 1986 |
Effects of (D-Met2,Pro5)-enkephalinamide and naloxone on pial vessels in cats.
Topics: Animals; Cats; Cerebral Arteries; Cerebrovascular Circulation; Enkephalins; Female; Male; Naloxone; Pia Mater; Sympathetic Nervous System; Vasoconstriction; Vasodilation | 1985 |
Lack of renal tubular and hemodynamic effects of non-selective and delta-opioid receptor antagonism.
Topics: Animals; Body Water; Dogs; Electrolytes; Enkephalin, Leucine; Female; Glomerular Filtration Rate; Hemodynamics; Kidney Tubules; Naloxone; Narcotic Antagonists | 1985 |
Interactions between enkephalin and dopamine in the control of locomotor activity in the rat: a new hypothesis.
Topics: Amphetamine; Animals; Dopamine; Drug Interactions; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Motor Activity; Naloxone; Pimozide; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Sites of analgesic actions of kyotorphin and D-kyotorphin in the central nervous system of rats.
Topics: Analgesics; Animals; Central Nervous System; Endorphins; Enkephalins; Leucine; Male; Naloxone; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord | 1985 |
Effects of enkephalins, morphine, and naloxone on pial arteries during perivascular microapplication.
Topics: Animals; Cats; Cerebral Arteries; Dose-Response Relationship, Drug; Enkephalins; Female; Male; Morphine; Naloxone; Pia Mater; Vascular Resistance; Vasodilation | 1985 |
Asymmetric behavior induced by enkephalinergic agents in the basal ganglia.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains | 1985 |
Footshock-induced analgesia: neurochemical correlates and pharmacological profile.
Topics: Age Factors; Analgesia; Animals; Brain; Electroshock; Endorphins; Enkephalins; Naloxone; Rats; Reserpine; Species Specificity | 1985 |
The EM autoradiographic distribution of label in tissue blocks of pallidum incorporating [3H]-Leu-enkephalin and [3H]-naloxone in vitro.
Topics: Animals; Autoradiography; Axons; Dendrites; Enkephalin, Leucine; Globus Pallidus; Microscopy, Electron; Naloxone; Neurons; Rats; Synapses | 1985 |
Studies on peptides. CXXXI. Synthesis of adrenorphin and enkephalin analogs.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Enkephalin, Methionine; Enkephalins; Male; Mice; Naloxone | 1985 |
[Inhibitory effect of electric needling on the defence reaction produced by hypothalamic stimulation in awake rabbits].
Topics: Acupuncture Therapy; Animals; Arcuate Nucleus of Hypothalamus; Blood Pressure; Defense Mechanisms; Electric Stimulation; Enkephalins; Female; Heart Rate; Hypothalamus, Middle; Kidney; Male; Naloxone; Rabbits; Sympathetic Nervous System | 1985 |
Differences in the effects of mu- and delta-opioid receptor antagonists upon plasma corticosterone levels in stressed mice.
Topics: Animals; Corticosterone; Enkephalin, Leucine; Ether; Male; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Physiological | 1984 |
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia.
Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1984 |
A novel phencyclidine analog interacts selectively with mu opioid receptors.
Topics: Analgesia; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Dihydromorphine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Naloxone; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, mu; Vas Deferens | 1984 |
[Binding sites of opiates and endogenous opioids in the oocytes of the toad Bufo viridis].
Topics: Animals; Benzomorphans; Binding Sites; Bufonidae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Kinetics; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Oocytes; Rabbits; Receptors, Opioid; Vas Deferens | 1984 |
Effect of beta-FNA on opiate delta receptor binding.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Oligopeptides; Protein Conformation; Rats; Receptors, Opioid | 1984 |
Solubilization and characterization of opioid binding sites from frog (Rana esculenta) brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Cell Membrane; Digitonin; Enkephalins; Kinetics; Naloxone; Rana esculenta; Rats; Receptors, Opioid; Solubility | 1984 |
Interaction of morphine-epoxide with multiple opiate receptors.
Topics: Analgesics; Animals; Brain; Dihydromorphine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Muscle Contraction; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Release of opioid peptides in canine hemorrhagic hypotension: effects of naloxone.
Topics: Adrenal Glands; Animals; beta-Endorphin; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hemorrhage; Hypotension; Male; Naloxone | 1984 |
[Stability of opiate receptors of wet and lyophilized preparations of rat brain membranes].
Topics: Animals; Binding Sites; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Freeze Drying; In Vitro Techniques; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Up-regulation of opiate receptors by opiate antagonists in neuroblastoma-glioma cell culture: the possibility of interaction with guanosine triphosphate-binding proteins.
Topics: Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Mu and delta opioid receptor interactions in a rat model of drug induced seizures.
Topics: Animals; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1984 |
Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin.
Topics: Animals; Body Temperature; Body Temperature Regulation; Cats; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Opioid receptor subtypes involved in the central inhibition of urinary bladder motility.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Morphine; Muscle Contraction; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1984 |
Involvement of endogenous opioid systems in social behavior of individually-housed mice.
Topics: Aggression; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Methadone; Mice; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Receptors, Opioid; Social Behavior; Social Isolation | 1984 |
Sequence analysis of social behaviour illustrating the actions of two antagonists of endogenous opioids.
Topics: Aggression; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Humans; Male; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Social Behavior | 1984 |
[Effect of beta-endorphin, enkephalins and their synthetic analogs on the neuronal electrical activity of the respiratory center in the medulla oblongata].
Topics: Animals; beta-Endorphin; Cats; Endorphins; Enkephalins; Iontophoresis; Medulla Oblongata; Microelectrodes; Morphine; Naloxone; Neurons; Rabbits; Respiration; Respiratory Center | 1984 |
Effect of electroconvulsive treatment on cerebral opioid receptors in the rat: changes in delta but not mu receptors.
Topics: Animals; Brain; Corpus Striatum; Electroshock; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Membranes; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1984 |
[Action of enkephalins on synaptic processes in the metasympathetic nervous system].
Topics: Animals; Electric Stimulation; Enkephalins; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Neuromuscular Junction; Receptors, Opioid; Sympathetic Nervous System; Sympatholytics; Synapses; Tetrodotoxin | 1984 |
Preferential binding to delta-receptors of the enkephalin-like tetrapeptide Tyr-Ile-Phe-Val. Electrophysiological and conformation studies.
Topics: Animals; Chemical Phenomena; Chemistry; Electrophysiology; Enkephalins; Evoked Potentials; Female; Guinea Pigs; Hypothalamus; In Vitro Techniques; Magnetic Resonance Spectroscopy; Naloxone; Neurons; Oligopeptides; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Evidence that naloxonazine produces prolonged antagonism of central delta opioid receptor activity in vivo.
Topics: Animals; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Naloxone; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1984 |
Evidence for the presynaptic localization of opiate binding sites on striatal efferent fibers.
Topics: Animals; Autoradiography; Corpus Striatum; Efferent Pathways; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Globus Pallidus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Substantia Nigra; Synaptic Membranes | 1984 |
Opposite effects of the delta- and mu-opioid receptor agonists on ventilation in conscious adult dogs.
Topics: Animals; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Respiratory Center | 1984 |
[Differences in the action of enkephalins, beta-endorphin, and morphine on spontaneous rhythmic movements of the isolated rabbit ileum].
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Gastrointestinal Motility; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Rabbits; Receptors, Opioid | 1984 |
Radioligands for probing opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1984 |
Two new opioid delta-receptor ligands: a highly selective agonist and a potent selective antagonist in in vitro isolated preparations.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Ligands; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1984 |
Inhibition via opioid mu- and delta-receptors of vagal transmission in rabbit isolated heart.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; In Vitro Techniques; Male; Morphine; Naloxone; Parasympathetic Nervous System; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptic Transmission; Vagus Nerve | 1984 |
Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Dihydromorphine; Enkephalin, Leucine; In Vitro Techniques; Indoles; Isoquinolines; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Synaptosomes | 1984 |
Mechanisms of opioid tolerance and dependence.
Topics: Animals; Drug Tolerance; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Humans; Hybrid Cells; Ileum; In Vitro Techniques; Male; Mice; Naloxone; Neurons; Receptors, Opioid; Substance-Related Disorders; Vas Deferens | 1984 |
Mu-receptor binding in physiological media: comparison with isolated tissue data.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Naloxone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, mu; Vas Deferens | 1984 |
Hamster vas deferens contains delta-opioid receptors.
Topics: Animals; Cricetinae; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Male; Mesocricetus; Naloxone; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1984 |
Opiate peptide receptors on intact NIE-115 neuroblastoma: radioligand binding properties, intracellular response, and effects of increasing membrane cholesterol.
Topics: Animals; Cholesterol; Clone Cells; Enkephalin, Leucine; Enkephalin, Methionine; Membrane Lipids; Mice; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1984 |
Mechanisms of multiple cellular adaptation processes in clonal cell lines during chronic opiate treatment.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanylyl Imidodiphosphate; Lanthanum; Mice; Naloxone; Narcotics; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Time Factors | 1984 |
Behavioral activating effects of opiates and opioid peptides.
Topics: Animals; Benzimidazoles; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Exploratory Behavior; Male; Methadone; Mice; Morphine; Motor Activity; Naloxone; Narcotics; Rats | 1980 |
Opiates and specific receptor binding of [3H]clonidine.
Topics: Animals; Binding, Competitive; Clonidine; Enkephalins; In Vitro Techniques; Morphine; Naloxone; Narcotics; Rats; Receptors, Drug | 1980 |
K+-evoked release of met-enkephalin from rat striatum in vitro: effect of putative neurotransmitters and morphine.
Topics: Animals; Corpus Striatum; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Haloperidol; Hydroxydopamines; Male; Morphine; Naloxone; Neurotransmitter Agents; Potassium; Radioimmunoassay; Rats | 1980 |
Actions of methionine enkephalin and morphine on single neuronal activity in Helix pomatia l.
Topics: Animals; Dopamine; Dopamine Antagonists; Endorphins; Enkephalin, Methionine; Enkephalins; Helix, Snails; Morphine; Naloxone; Neurons; Receptors, Opioid | 1980 |
Comparative effects of somatostatin and enkephalins on the guinea pig ileum and the rat vas deferens.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Rats; Somatostatin; Time Factors; Vas Deferens | 1980 |
Effects of beta-endorphin, met-enkephalin and somatostatin on the neurotensin-induced neurogenic contraction in the guinea-pig ileum.
Topics: Animals; Atropine; beta-Endorphin; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Neurotensin; Somatostatin | 1981 |
Morphine-like activities of synthetic enkephalin analogues.
Topics: Analgesia; Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Naloxone; Rats; Structure-Activity Relationship | 1981 |
MIF-I suppresses deprivation-induced fluid consumption in rats.
Topics: Animals; Drinking; Dynorphins; Endorphins; Enkephalins; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1980 |
Mu and delta opiate receptors in rat brain are affected by GTP but not by MIF-1.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanosine Triphosphate; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium; Temperature | 1981 |
Opiate peptides modulate somatostatin release from dispersed hypothalamic cells.
Topics: Animals; beta-Endorphin; Cold Temperature; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamus; In Vitro Techniques; Male; Naloxone; Rats; Rats, Inbred Strains; Somatostatin | 1981 |
Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Ligands; Morphine Derivatives; Myenteric Plexus; Naloxone; Peptide Fragments; Receptors, Opioid | 1982 |
Specific opiate receptors on isolated mammalian gastric smooth muscle cells.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalins; Gastric Mucosa; Guinea Pigs; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Neurotransmitter Agents; Receptors, Opioid | 1982 |
Noradrenergic terminal excitability: effects of opioids.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Locus Coeruleus; Male; Morphine; Naloxone; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1982 |
Ethanol, salsolinol and tetrahydropapaveroline alter the discharge of neurons in several brain regions: comparison to opioid effects.
Topics: Animals; Brain; Electric Conductivity; Enkephalin, Methionine; Enkephalins; Ethanol; Glutamates; Glutamic Acid; Hippocampus; Isoquinolines; Male; Naloxone; Narcotics; Neurons; Organ Specificity; Papaverine; Rats; Rats, Inbred Strains; Salsoline Alkaloids; Tetrahydropapaveroline | 1982 |
Stimulation of prolactin secretion in the rat by alpha-neo-endorphin, beta-neo-endorphin and dynorphin.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalins; Gonadotropin-Releasing Hormone; Injections, Intraventricular; Male; Naloxone; Pituitary Gland; Prolactin; Protein Precursors; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1982 |
In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Injections, Spinal; Male; Naloxone; Pain; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1982 |
Potency of three opiate antagonists to reverse the inhibitory activity of dynorphin, enkephalins and opioid-like alkaloids on the guinea pig ileum.
Topics: Animals; Azocines; Benzomorphans; Cyclazocine; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Muscle, Smooth; Naloxone; Narcotic Antagonists | 1982 |
Inhibition by enkephalins of peristaltic activity of the rabbit ileum and its reversal by naloxone.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Ileum; In Vitro Techniques; Male; Naloxone; Peristalsis; Rabbits | 1982 |
Opioid peptides in the hippocampus: anatomical and physiological considerations.
Topics: Animals; Dynorphins; Electroencephalography; Endorphins; Enkephalins; Hippocampus; Magnesium; Male; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
MIF-1 does not act like naloxone in antagonizing the cardiovascular activity of leucine-enkephalin in the conscious dog.
Topics: Animals; Blood Pressure; Dogs; Enkephalin, Leucine; Heart Rate; Hypothalamic Hormones; MSH Release-Inhibiting Hormone; Naloxone; Pentobarbital; Peptides; Receptors, Opioid | 1982 |
Regional release of [3H]dopamine from rat brain in vitro: effects of opioids on release induced by potassium, nicotine, and L-glutamic acid.
Topics: Animals; Brain; Dopamine; Endorphins; Enkephalins; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Morphine; Naloxone; Narcotics; Nicotine; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin; Tritium | 1983 |
Opioid peptide effects on insulin release and c-AMP in islets of Langerhans.
Topics: Animals; Cyclic AMP; Dynorphins; Endorphins; Enkephalins; Female; Insulin; Insulin Secretion; Islets of Langerhans; Naloxone; Rats; Rats, Inbred Strains | 1983 |
A novel opioid peptide, leumorphin, acts as an agonist at the kappa opiate receptor.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Naloxone; Neuromuscular Junction; Protein Precursors; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Swine; Vas Deferens | 1983 |
Differential modification of opiate receptor activity by arylsulfatase treatment.
Topics: Analgesia; Analgesics, Opioid; Animals; Arylsulfatases; beta-Endorphin; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Antagonism; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hormones; Kinetics; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Sulfatases | 1983 |
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Morphine; Naloxone; Somatostatin | 1983 |
Enkephalinergic control of somatostatin secretion from the perfused rat stomach.
Topics: Animals; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Male; Naloxone; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Stomach; Vagus Nerve | 1983 |
Effect of morphine, leu-enkephalin and beta-casomorphins on basal somatostatin release in dogs.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Morphine; Naloxone; Somatostatin | 1983 |
Inhibition of an opioid-evoked vagal reflex in rats by naloxone, SMS 201-995 and ICI 154, 129.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Kinetics; Male; Morphine; Naloxone; Octreotide; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Somatostatin; Vagus Nerve | 1983 |
Plasma immunoreactive beta-endorphin and enkephalin concentration in healthy subjects before and after electroacupuncture.
Topics: Acupuncture Therapy; Adrenocorticotropic Hormone; Adult; beta-Endorphin; Electric Stimulation Therapy; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Naloxone; Radioimmunoassay | 1983 |
Opioid receptor selectivity of dynorphin gene products.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Peptide Fragments; Protein Precursors; Receptors, Opioid | 1984 |
Dynorphin-A alters the excitability of pyramidal neurons of the rat hippocampus in vitro.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Evoked Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Naloxone; Neurons; Peptide Fragments; Pyramidal Tracts; Rats | 1983 |
Pharmacological identification of delta and mu opiate receptors on bulbar respiratory neurons.
Topics: Animals; Cats; Enkephalin, Leucine; Glutamates; Glutamic Acid; Medulla Oblongata; Naloxone; Neurons; Oligopeptides; Receptors, Opioid; Respiratory Center; Respiratory Function Tests | 1984 |
Opioid receptor sub-types involved in the control of transmitter release in cortex of the brain of the rat.
Topics: Animals; beta-Lipotropin; Cerebral Cortex; Clomipramine; Edetic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estradiol; In Vitro Techniques; Male; Morphine; Morphine Derivatives; Naloxone; Narcotics; Neurotransmitter Agents; Norepinephrine; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin | 1984 |
Dynorphin reduces calcium-dependent action potential duration by decreasing voltage-dependent calcium conductance.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Dynorphins; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Peptide Fragments; Receptors, Opioid | 1984 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Opiates stimulate low Km GTPase in brain.
Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; GTP Phosphohydrolases; Guanosine Triphosphate; Male; Naloxone; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Cyclazocine; Dynorphins; Electric Conductivity; Enkephalins; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Dynorphin-(1-13) restores the potency of morphine on the tolerant guinea pig ileum.
Topics: Animals; beta-Endorphin; Cyclazocine; Drug Interactions; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments | 1984 |
Human leumorphin is a potent, kappa opioid receptor agonist.
Topics: Animals; Benzomorphans; Depression, Chemical; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Humans; Ileum; Male; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Swine; Vas Deferens | 1984 |
The role of opioid receptor sub-types in tifluadom-induced feeding.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Convulsants; Eating; Enkephalin, Leucine; Flumazenil; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1984 |
Behavioural and biochemical effects in C57BL/6J mice after a prolonged treatment with the delta-opiate antagonist ICI 154129.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain Chemistry; Brain Stem; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Levorphanol; Male; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Differential effects of various opioid peptides on vasopressin and oxytocin release from the rat pituitary in vitro.
Topics: Animals; beta-Endorphin; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Female; In Vitro Techniques; Naloxone; Oxytocin; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains; Vasopressins | 1984 |
Binding of [3H]clonidine to membranes from cow neurohypophysis and cerebral cortex of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Cerebral Cortex; Clonidine; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Membranes; Morphine; Naloxone; Narcotics; Pituitary Gland, Posterior; Rats | 1984 |
Tail-pinch method in vitro and the effects of some antinociceptive compounds.
Topics: Analgesics; Animals; Animals, Newborn; Baclofen; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Stereotyped Behavior; Tail | 1984 |
Anatomical relationship between opioid peptides and receptors in rhesus monkey brain.
Topics: Animals; Benzomorphans; Brain; Brain Mapping; Dynorphins; Endorphins; Enkephalins; Macaca mulatta; Naloxone; Pro-Opiomelanocortin; Radioligand Assay; Receptors, Opioid; Synaptic Transmission | 1984 |
[Inhibitory effects of dynorphin on electric field stimulation induced contraction of blood vessels in vitro].
Topics: Animals; Dogs; Dynorphins; Ear; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; In Vitro Techniques; Mesenteric Arteries; Naloxone; Rabbits; Receptors, Opioid; Vasoconstriction | 1984 |
Alterations by captopril of pain reactions due to thermal stimulation of the mouse foot: interactions with morphine, naloxone and aprotinin.
Topics: Animals; Aprotinin; Behavior, Animal; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Enkephalins; Female; Hot Temperature; Kinins; Male; Mice; Morphine; Naloxone; Nociceptors; Proline; Prostaglandins; Reaction Time; Time Factors | 1980 |
Depression and facilitation of synaptic responses in cat dorsal horn by substance P administered into substantia gelatinosa.
Topics: Action Potentials; Animals; Cats; Electrophoresis; Enkephalin, Leucine; Enkephalins; Hot Temperature; Naloxone; Neurons, Afferent; Spinal Cord; Substance P; Substantia Gelatinosa; Synapses | 1980 |
Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum.
Topics: Acetylcholinesterase; Animals; Axonal Transport; Caudate Nucleus; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Leucine; Naloxone; Proline; Rats; Receptors, Opioid | 1981 |
Effects of beta-endorphin, vasoactive intestinal polypeptide and cholecystokinin octapeptide on cat carotid chemoreceptor activity.
Topics: Animals; beta-Endorphin; Carotid Body; Cats; Cholecystokinin; Endorphins; Enkephalin, Methionine; Enkephalins; Gastrointestinal Hormones; Naloxone; Sincalide; Substance P; Vasoactive Intestinal Peptide | 1981 |
Contractile effect of morphine and related opioid alkaloids, beta-endorphin and methionine enkephalin on the isolated colon from Long Evans rats.
Topics: Animals; beta-Endorphin; Calcium; Colon; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Hexamethonium Compounds; Histamine Release; Humans; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Narcotics; Opioid-Related Disorders; Rats; Rats, Inbred Strains; Tetrodotoxin | 1981 |
Analgesic activity of substance P in rats: apparent mediation by met-enkephalin release.
Topics: Analgesia; Animals; Bacitracin; beta-Endorphin; Cerebral Ventricles; Endorphins; Enkephalin, Methionine; Enkephalins; Immunologic Techniques; Male; Naloxone; Protease Inhibitors; Rats; Substance P; Vocalization, Animal | 1982 |
Quaternary opiate antagonists lower blood pressure and inhibit leucine-enkephalin responses.
Topics: Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Heart Rate; Hydromorphone; Naloxone; Naltrexone; Oxymorphone; Quaternary Ammonium Compounds | 1983 |
Studies on the opiate receptor-mediated inhibition of K+-stimulated cholecystokinin and substance P release from cat hypothalamus in vitro.
Topics: Animals; Cats; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamus; Morphine; Naloxone; Potassium; Receptors, Opioid; Substance P | 1984 |
Effects of iontophoretically released peptides on primate spinothalamic tract cells.
Topics: Action Potentials; Animals; Cholecystokinin; Drug Interactions; Enkephalin, Leucine; Enkephalin, Methionine; Iontophoresis; Macaca fascicularis; Naloxone; Neurons; Neurotransmitter Agents; Spinothalamic Tracts; Substance P | 1984 |
Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Sympathetic; Guinea Pigs; Male; Naloxone; Neurotransmitter Agents; Substance P; Synaptic Transmission | 1982 |
Endorphins stimulate normal human peripheral blood lymphocyte natural killer activity.
Topics: alpha-Endorphin; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; gamma-Endorphin; Humans; Interferons; Killer Cells, Natural; Morphine; Naloxone | 1984 |
Histamine release induced by dynorphin-(1-13) from rat mast cells.
Topics: Animals; Calcium Chloride; Cromolyn Sodium; Dynorphins; Enkephalin, Leucine; Histamine Release; Hydrogen-Ion Concentration; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mast Cells; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Temperature; Time Factors | 1984 |
Effects of morphine, enkephalins and naloxone on postprandial gastric acid secretion, gastric emptying and gastrin release in dogs.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Food; Gastric Acid; Gastric Emptying; Gastrins; Morphine; Naloxone | 1984 |
[The effects of hemicholinum-3 and naloxone on the pressor response caused by central vagal stimulation].
Topics: Animals; Blood Pressure; Brain; Cats; Enkephalins; Hemicholinium 3; Naloxone; Vagus Nerve | 1982 |
Comparison of methionine-enkephalin and morphine in the stimulation of gastric acid secretion in the dog.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Gastric Juice; Gastric Mucosa; Gastrins; Morphine; Naloxone; Pentagastrin; Receptors, Cholinergic; Receptors, Histamine H2; Receptors, Opioid; Regional Blood Flow | 1980 |
Demonstration of stereospecific opiate binding in the nervous tissue of the marine mollusc Mytilus edulis.
Topics: Animals; Dextrorphan; Dopamine; Enkephalins; Ganglia; Levallorphan; Mollusca; Naloxone; Receptors, Opioid | 1980 |
Modulation of nicotinic receptors by opiate receptor agonists in cultured adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Catecholamines; Cattle; Cells, Cultured; Endorphins; Enkephalins; Kinetics; Morphine; Naloxone; Nicotine; Receptors, Cholinergic; Receptors, Nicotinic; Receptors, Opioid | 1980 |
Pain sensitivity and opioid activity in genetically and experimentally hypertensive rats.
Topics: Animals; Blood Pressure; Brain; Desoxycorticosterone; Enkephalins; Hypertension; Hypertension, Renal; Male; Naloxone; Pain; Pituitary Gland; Rats; Receptors, Opioid; Spinal Cord | 1980 |
GTP modulation of opiate receptors in regions of rat brain and possible mechanism of GTP action.
Topics: Amygdala; Animals; Brain; Corpus Striatum; Enkephalins; Frontal Lobe; Guanosine Triphosphate; Hippocampus; Male; Naloxone; Rats; Receptors, Opioid | 1980 |
[Properties of opioid receptor binding in the rat brain (author's transl)].
Topics: Animals; Brain; Cations, Divalent; Endorphins; Enkephalins; Male; Naloxone; Radioligand Assay; Rats; Receptors, Opioid | 1980 |
Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Ethylmaleimide; Kinetics; Ligands; Male; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1980 |
Effect of antenatal exposure to opiates on the development of opiate receptors in rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Enkephalin, Methionine; Enkephalins; Female; Fetus; Maternal-Fetal Exchange; Morphine; Naloxone; Pregnancy; Rats; Receptors, Opioid | 1980 |
Opiate receptors: problems of definition and characterization.
Topics: Animals; Binding Sites; Brain; Caudate Nucleus; Cyclazocine; Endorphins; Enkephalins; Hippocampus; Humans; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1980 |
Met-enkephalin levels and opiate receptors in the spinal cord of chronic suffering rats.
Topics: Animals; Arthritis, Experimental; Endorphins; Enkephalins; Naloxone; Pain, Intractable; Rats; Receptors, Opioid; Spinal Cord | 1980 |
Excitatory action of opioid peptides and opiates on cultured hippocampal pyramidal cells.
Topics: Animals; Culture Techniques; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Evoked Potentials; Fentanyl; Hippocampus; Morphine; Naloxone; Neurons; Rats; Synaptic Transmission | 1980 |
The effects of opiate agonists on growth hormone and prolactin release in rats.
Topics: Animals; Apomorphine; Enkephalins; Growth Hormone; Male; Methadone; Morphine; Naloxone; Naltrexone; Parasympathomimetics; Prolactin; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Opioid; Secretory Rate | 1980 |
Cluster formation of opiate (enkephalin) receptors in neuroblastoma cells: differences between agonists and antagonists and possible relationships to biological functions.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Enkephalins; Enzyme Activation; Membrane Fluidity; Morphine; Naloxone; Neoplasms, Experimental; Neuroblastoma; Prostaglandins E; Receptors, Opioid; Sulfhydryl Reagents | 1980 |
Biochemical and autoradiographic evidence for type 1 and type 2 opiate receptors.
Topics: Animals; Autoradiography; Brain; Enkephalins; Guanosine Triphosphate; Ligands; Naloxone; Rats; Receptors, Opioid | 1980 |
Lack of cross-tolerance between morphine and Leu-enkephalin in the mouse vas deferens.
Topics: Animals; Drug Tolerance; Electric Stimulation; Endorphins; Enkephalins; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Neuromuscular Junction; Receptors, Opioid; Vas Deferens | 1980 |
Enkephalin-induced inhibition of hypothalmaic paraventricular neurons.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Evoked Potentials; Hypothalamus; Male; Morphine; Naloxone; Neural Inhibition; Paraventricular Hypothalamic Nucleus; Rats; Receptors, Opioid | 1980 |
'gamma-MSH' fragments from ACTH-beta-LPH precursor have an affinity for opiate receptors.
Topics: Adrenocorticotropic Hormone; Animals; beta-Lipotropin; Brain; Enkephalins; In Vitro Techniques; Male; Melanocyte-Stimulating Hormones; Naloxone; Rats; Receptors, Opioid; Sodium | 1980 |
Rapid development of tolerance to the hyperthermic effect of beta-endorphin, and cross-tolerance between the enkephalins and beta-endorphin.
Topics: Animals; beta-Endorphin; Body Temperature; Drug Tolerance; Endorphins; Enkephalins; Humans; Mice; Mice, Inbred ICR; Naloxone; Temperature; Time Factors | 1980 |
Effect of D-alanine methionine enkephalin amide on ion transport in rabbit ileum.
Topics: Animals; Chlorides; Cyclic AMP; Endorphins; Enkephalin, Methionine; Enkephalins; Epinephrine; Hydroxydopamines; Ileum; In Vitro Techniques; Male; Naloxone; Phentolamine; Rabbits; Sodium | 1980 |
In vitro cyclic AMP-mediated lipolytic activity of endorphins, enkephalins and naloxone.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Cyclic AMP; Endorphins; Enkephalins; Fatty Acids; In Vitro Techniques; Lipolysis; Male; Naloxone; Rabbits | 1980 |
[Preferential development of flexion of the left or right hindlimb as a result of treatment with methionine-enkephalin or leucine-enkephalin, respectively].
Topics: Animals; Dominance, Cerebral; Endorphins; Enkephalins; Hindlimb; Leucine; Methionine; Naloxone; Posture; Rats; Receptors, Opioid; Structure-Activity Relationship | 1980 |
Central inhibition of basal pancreatic and gastric secretions by beta-endorphin in rats.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalins; Gastric Juice; Gastrointestinal Motility; Male; Morphine; Naloxone; Pancreatic Juice; Rats | 1980 |
Multiple opiate receptors: [3H]ethylketocyclazocine receptor binding and ketocyclazocine analgesia.
Topics: Analgesics; Animals; Brain; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Mice; Morphine; Motor Activity; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1980 |
Methionine enkephalin inhibits the bursting activity of the Br-type neuron in Helix pomatia L.
Topics: Animals; Electrophysiology; Endorphins; Enkephalin, Methionine; Enkephalins; Helix, Snails; Naloxone; Neurons; Receptors, Opioid | 1980 |
Novel analogues of enkephalin: indentification of functional groups required for biological activity.
Topics: Animals; Bacitracin; Binding, Competitive; Brain; Chromatography, High Pressure Liquid; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Receptors, Opioid; Structure-Activity Relationship | 1980 |
Effects of methionine-enkephalin on intestinal circulation and oxygen consumption.
Topics: Animals; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Female; Ileum; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Oxygen Consumption; Receptors, Opioid; Regional Blood Flow | 1980 |
Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Diprenorphine; Endorphins; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Morphinans; Morphine; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Synaptic Membranes | 1980 |
Morphine and opioid peptides reduce paraventricular neuronal activity: studies on the rat hypothalamic slice preparation.
Topics: Animals; beta-Endorphin; Depression, Chemical; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; In Vitro Techniques; Male; Morphine; Naloxone; Neurons; Paraventricular Hypothalamic Nucleus; Rats | 1980 |
Opioid peptides and their receptors.
Topics: Animals; Brain; Dogs; Endorphins; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Receptors, Opioid; Vas Deferens | 1980 |
[Effect of apomorphine on rat brain opiate receptors].
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Enkephalins; Male; Naloxone; Rats; Receptors, Opioid; Sodium Chloride | 1980 |
Influence of opiates on ion transport across rabbit ileal mucosa.
Topics: Animals; Biological Transport; Dose-Response Relationship, Drug; Electrolytes; Enkephalins; Ileum; In Vitro Techniques; Intestinal Mucosa; Male; Morphine; Naloxone; Narcotics; Rabbits; Receptors, Opioid | 1981 |
Opiate binding sites in the retina: properties and distribution.
Topics: Animals; Binding Sites; Bufo marinus; Cattle; Cell Membrane; Enkephalin, Methionine; Enkephalins; Etorphine; Fishes; Male; Naloxone; Rats; Receptors, Opioid; Retina | 1980 |
Effects of enkephalin, morphine, and naloxone on the electrical activity of the in vitro hippocampal slice preparation.
Topics: Action Potentials; Animals; Culture Techniques; Dendrites; Endorphins; Enkephalins; Hippocampus; Male; Morphine; Naloxone; Neural Inhibition; Pyramidal Tracts; Rats; Synapses; Synaptic Transmission | 1981 |
Opiate receptor gradients in monkey cerebral cortex: correspondence with sensory processing hierarchies.
Topics: Animals; Auditory Cortex; Brain Mapping; Cerebral Cortex; Enkephalins; Female; Macaca mulatta; Male; Naloxone; Receptors, Opioid; Visual Cortex | 1981 |
Met-enkephalin[Arg6,Phe7] interacts with the kappa-receptors on guinea-pig ileum.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Naloxone; Receptors, Opioid | 1980 |
Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors.
Topics: Animals; Binding, Competitive; Caseins; Dihydromorphine; Endorphins; Enkephalins; Guanosine Triphosphate; Guinea Pigs; Ileum; Male; Mice; Naloxone; Rats; Receptors, Opioid; Sodium; Vas Deferens | 1981 |
Behavioral confirmation of "diffuse noxious inhibitory controls" (DNIC) and evidence for a role of endogenous opiates.
Topics: Animals; Behavior, Animal; Benzoquinones; Endorphins; Enkephalins; Ganglia, Spinal; Male; Naloxone; Neural Inhibition; Nociceptors; Quinones; Rats; Receptors, Opioid | 1981 |
Stress-induced release of brain and pituitary beta-endorphin: major role of endorphins in generation of hyperthermia, not analgesia.
Topics: Animals; beta-Endorphin; Body Temperature Regulation; Electroshock; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Morphine; Naloxone; Nociceptors; Pituitary Gland; Rats; Stress, Physiological | 1981 |
Mature spinal ganglion cells are not sensitive to opiate receptor mediated actions.
Topics: Action Potentials; Aminopyridines; Animals; Barium; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Ganglia, Spinal; Iontophoresis; Morphine; Morphine Derivatives; Naloxone; Narcotics; Rats; Receptors, Opioid | 1981 |
Interaction of putative opioid peptides with opiate receptors.
Topics: Adrenocorticotropic Hormone; Animals; Binding, Competitive; Cholecystokinin; Endorphins; Enkephalins; Male; Naloxone; Radioligand Assay; Rats; Receptors, Opioid | 1981 |
Central effects of morphine, levorphanol, (-)-methadone and the opioid-like peptides beta-endorphin and D-alanine2- methionine enkephalinamide on urine volume outflow and electrolytes.
Topics: Animals; beta-Endorphin; Brain; Diuresis; Electrolytes; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Levorphanol; Male; Methadone; Morphine; Naloxone; Narcotics; Rats; Vasopressins | 1981 |
Interactions of leucine enkephalin and narcotics with opioid receptors.
Topics: Analgesics; Animals; Corpus Striatum; Drug Tolerance; Endorphins; Enkephalin, Leucine; Enkephalins; Humans; In Vitro Techniques; Male; Mice; Morphine; Naloxone; Narcotics; Receptors, Opioid; Substance-Related Disorders | 1981 |
Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors.
Topics: Animals; Behavior, Animal; beta-Lipotropin; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Naloxone; Pain; Peptide Fragments; Radioligand Assay; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1981 |
Opiate receptors in the rabbit iris.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Iris; Male; Morphine; Naloxone; Pupil; Rabbits; Receptors, Opioid | 1980 |
Opioid inhibition of dopamine release from nervous tissue of Mytilus edulis and Octopus bimaculatus.
Topics: Animals; Brain; Dopamine; Enkephalins; Ganglia; Mollusca; Morphine; Naloxone; Narcotics; Octopodiformes; Receptors, Opioid; Snails; Synaptic Transmission | 1981 |
Enkephalin receptors in the emetic chemoreceptor trigger zone of the dog.
Topics: Animals; Apomorphine; Chemoreceptor Cells; Dogs; Emetics; Enkephalins; Female; Injections, Intraventricular; Male; Morphine; Naloxone; Receptors, Opioid | 1981 |
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons | 1981 |
The actions of naloxazone on the binding and analgesic properties of morphiceptin (NH2Tyr-Pro-Phe-Pro-CONH2), a selective mu-receptor ligand.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; In Vitro Techniques; Kinetics; Ligands; Naloxone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1981 |
Naloxazone irreversibly inhibits the high affinity binding of [125I]D-ala2-D-leu5-enkephalin.
Topics: Animals; Binding, Competitive; Brain; Cells, Cultured; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Kinetics; Membranes; Morphine; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid | 1981 |
Alcohol addiction: are the endogenous opioids involved?
Topics: Acetaldehyde; Alcoholism; Animals; Endorphins; Enkephalins; Humans; Isoquinolines; Mice; Naloxone; Rats; Receptors, Opioid; Tetrahydroisoquinolines | 1981 |
Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.
Topics: Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Naloxone; Naltrexone; Narcotics; Phenoxybenzamine; Receptors, Opioid | 1981 |
Multiple opiate receptors: phylogenetic differences.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Goldfish; Male; Naloxone; Rats; Receptors, Opioid; Species Specificity; Turtles; Xenopus laevis | 1981 |
Allosteric modulation by leucine-enkephalin of [3H]naloxone binding in rat brain.
Topics: Allosteric Site; Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Electronic, steric, and hydrophobic factors influencing the action of enkephalin-like peptides on opiate receptors.
Topics: Animals; Brain; Endopeptidases; Endorphins; Enkephalins; Guinea Pigs; Ileum; Naloxone; Protein Conformation; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Evidence for distinct subcellular sites of opiate receptors. Demonstration of opiate receptors in smooth microsomal fractions isolated from rat brain.
Topics: Animals; Binding, Competitive; Brain; Cell Fractionation; Enkephalin, Methionine; Enkephalins; Guanylyl Imidodiphosphate; Kinetics; Microscopy, Electron; Microsomes; Naloxone; Rats; Receptors, Opioid; Subcellular Fractions | 1981 |
Effect of lithium and sodium ions on opiate- and dopamine-receptor binding.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Lithium; Naloxone; Rats; Receptors, Dopamine; Receptors, Opioid; Sodium; Spiperone | 1981 |
Effects of centrally administered endogenous opioid peptides on drinking behavior, increased plasma vasopressin concentration and pressor response to hypertonic sodium chloride.
Topics: Animals; beta-Endorphin; Blood Pressure; Drinking Behavior; Endorphins; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Kinetics; Male; Naloxone; Polyethylene Glycols; Rats; Sodium Chloride; Vasopressins | 1981 |
Opiate receptor heterogeneity in human brain regions.
Topics: Binding, Competitive; Brain; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Kinetics; Naloxone; Organ Specificity; Receptors, Opioid | 1981 |
Naloxone has a direct effect on the adrenal cortex.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Naloxone; Rats | 1981 |
Glucocorticoids elevate the level of enkephalin-like peptides in neuroblastoma x glioma hybrid cells.
Topics: Alprostadil; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Dexamethasone; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Glucocorticoids; Hybrid Cells; Naloxone; Neuroblastoma; Prostaglandins E | 1981 |
A met-enkephalin analog inhibits adrenocorticotropin secretion by cultured pituitary cells from a patient with Nelson's syndrome.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cells, Cultured; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Female; Hormones; Humans; Naloxone; Nelson Syndrome; Pituitary Neoplasms | 1981 |
Comparison of the anticonvulsant effects of opioid peptides and etorphine in rats after icv administration.
Topics: Animals; Anticonvulsants; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Flurothyl; Male; Morphinans; Naloxone; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1981 |
Interactions of ligands with morphine and enkephalin receptors are differentially affected by guanine nucleotide.
Topics: Animals; Brain; Cells, Cultured; Diprenorphine; Endorphins; Enkephalins; Guanosine Triphosphate; In Vitro Techniques; Magnesium; Naloxone; Neoplasms, Experimental; Neuroblastoma; Rats; Receptors, Opioid; Sodium | 1981 |
Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.
Topics: Animals; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Nitrogen Mustard Compounds; Prostaglandins E, Synthetic; Rats; Receptors, Opioid | 1981 |
Enkephalin as a transmitter for presynaptic inhibition in sympathetic ganglia.
Topics: Acetylcholine; Animals; Endorphins; Enkephalins; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Mesentery; Naloxone; Neural Inhibition; Synapses; Synaptic Transmission | 1981 |
Plasma norepinephrine, epinephrine and dopamine responses to intracerebral administration of a met-enkephalin analog, D-ala2-met-enkephalinamide, in rats.
Topics: Animals; beta-Endorphin; Cisterna Magna; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Epinephrine; Injections; Injections, Intra-Arterial; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains | 1981 |
Neurons in the frontal cortex of the rat carry multiple opiate receptors.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Frontal Lobe; gamma-Aminobutyric Acid; Male; Morphine; Naloxone; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Strain differences in opiate receptors in mouse brain.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naloxone; Receptors, Opioid; Species Specificity | 1981 |
Effects of opioid peptides on thermoregulation.
Topics: Animals; beta-Endorphin; Body Temperature Regulation; Cats; Cattle; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Naloxone; Naltrexone; Narcotics; Rats; Structure-Activity Relationship | 1981 |
Opiates and enkephalins: a common binding site mediates their analgesic actions in rats.
Topics: Analgesics; Animals; Binding, Competitive; Endorphins; Enkephalins; Morphine; Naloxone; Narcotics; Rats; Receptors, Opioid; Time Factors | 1981 |
Morphine and opioid peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells in vitro without alteration of membrane potential.
Topics: Animals; Endorphins; Enkephalins; Hippocampus; Male; Membrane Potentials; Morphine; Naloxone; Neural Inhibition; Rats; Receptors, Opioid | 1981 |
A comparison of the ability of opioid peptides and opiates to affect active avoidance conditioning in rats.
Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Diprenorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Narcotics; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Ontogeny of opiate receptors in rat forebrain: visualization by in vitro autoradiography.
Topics: Aging; Animals; Autoradiography; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Naloxone; Neurons; Olfactory Pathways; Pregnancy; Rats; Receptors, Opioid; Septum Pellucidum; Telencephalon | 1981 |
The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease.
Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; Adult; beta-Endorphin; beta-Lipotropin; Cushing Syndrome; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Hormones; Humans; Male; Middle Aged; Naloxone | 1981 |
Classification of multiple morphine and enkephalin binding sites in the central nervous system.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Morphine; Naloxone; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
On the presence of met 5-enkephalin receptors on the plasma membrane of Deiters' neurons and their modulation of GABA transport.
Topics: Animals; Biological Transport; Cell Membrane; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Naloxone; Neurons; Rabbits; Receptors, Opioid; Vestibular Nuclei; Vestibular Nucleus, Lateral | 1981 |
A quantitative analysis of the shaking behavior induced in rats by beta-endorphin and [D-Ala2, Met5]enkephalinamide.
Topics: Animals; Behavior, Animal; beta-Endorphin; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Differentiation of agonist conformation and antagonist conformation in multiple opioid receptors.
Topics: Animals; Brain; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Molecular Weight; Naloxone; Protein Conformation; Rats; Receptors, Opioid | 1981 |
Morphine-induced hyperthermia: lack of cross-tolerance with enkephalin analogs.
Topics: Animals; Body Temperature Regulation; Cats; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Morphine; Naloxone; Pentazocine; Receptors, Opioid | 1982 |
[Modulation by endogenous opioid peptides of non-adrenergic neurotransmission in the guinea-pig taenia coli (author's transl)].
Topics: Animals; Colon; Depression, Chemical; Endorphins; Enkephalins; Fluorescent Antibody Technique; Guinea Pigs; Male; Muscle Tonus; Naloxone; Parasympathetic Nervous System; Sympathetic Nervous System; Synaptic Transmission | 1981 |
Effects of a Met-enkephalin analogue and naloxone infusion on anterior pituitary hormone secretion in acromegaly.
Topics: Acromegaly; Adult; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Female; Follicle Stimulating Hormone; Growth Hormone; Hormones; Humans; Hydrocortisone; Luteinizing Hormone; Male; Middle Aged; Naloxone; Pituitary Hormones, Anterior; Prolactin; Receptors, Opioid; Thyrotropin | 1981 |
Function and regulation of methionine5-enkephalin and its receptors in murine neuroblastoma cells.
Topics: Alprostadil; Animals; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Cyclic AMP; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Mice; Naloxone; Neoplasms, Experimental; Neuroblastoma; Prostaglandins E; Receptors, Opioid | 1982 |
Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.
Topics: Analgesia; Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Naloxone; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1981 |
Are endogenous opiates involved in potentiation of field potentials in the hippocampus of the rat?
Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; Evoked Potentials; Hippocampus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptic Transmission | 1981 |
Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy.
Topics: Analgesia; Analgesics; Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mice; Morphine; Naloxone; Peptide Fragments; Receptors, Opioid | 1981 |
Opiate receptor-mediated inhibition of adenylate cyclase in rat striatal plasma membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Membrane; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Guanosine Triphosphate; Kinetics; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Opioid peptides induce reduction of enkephalin receptors in cultured neuroblastoma cells.
Topics: Animals; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Kinetics; Mice; Naloxone; Narcotics; Neuroblastoma; Neurons; Rats; Receptors, Opioid; Structure-Activity Relationship | 1982 |
Effects of a synthetic Met5-enkephalin analog on plasma luteinizing hormone and prolactin levels in conscious orchiectomized rats.
Topics: 5,6-Dihydroxytryptamine; Animals; beta-Endorphin; Castration; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Fenclonine; Humans; Luteinizing Hormone; Male; Naloxone; Pimozide; Prolactin; Rats; Rats, Inbred Strains | 1982 |
Postsynaptic inhibitory effects of Met- and Leu-enkephalin on endocrine and adjacent neurones in the preoptic-septal region of the guinea pig.
Topics: Animals; Brain; Electric Stimulation; Endocrine Glands; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Guinea Pigs; Hypothalamus; Magnesium; Naloxone; Neurons; Preoptic Area; Receptors, Opioid | 1982 |
[Sensitivity of hypothalamic neurons to beta-endomorphin, met-enkephalin, and thyroliberin].
Topics: Animals; beta-Endorphin; Depression, Chemical; Electrophysiology; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Naloxone; Rats; Stimulation, Chemical; Thyrotropin-Releasing Hormone | 1982 |
Evidence against transmitter function of met-enkephalin and chemosynaptic impulse generation in "Merkel cell" mechanoreceptors.
Topics: Afferent Pathways; Animals; Axons; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials, Somatosensory; Mechanoreceptors; Naloxone; Nerve Fibers; Skin; Synapses; Synaptic Transmission | 1982 |
Opiate receptor subclasses differ in their conformational requirements.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalins; Ligands; Naloxone; Protein Conformation; Rats; Receptors, Opioid; Structure-Activity Relationship | 1982 |
D-Ala2,D-Leu5-enkephalin generalizes to a discriminative stimulus produced by fentanyl but not ethylketocyclazocine.
Topics: Animals; Cyclazocine; Discrimination, Psychological; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Fentanyl; Generalization, Stimulus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Development of methionine-enkephalin and naloxone binding sites in regions of rat brain.
Topics: Aging; Animals; Binding, Competitive; Brain; Brain Stem; Cerebellum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Tissue Distribution | 1982 |
Differential postnatal development of mu and delta opiate receptors.
Topics: Aging; Animals; Brain; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1982 |
Effects of a met-enkephalin analog on adrenocorticotropin (ACTH), growth hormone, and prolactin in patients with ACTH hypersecretion.
Topics: Addison Disease; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Cushing Syndrome; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Female; Follicle Stimulating Hormone; Growth Hormone; Humans; Hydrocortisone; Luteinizing Hormone; Male; Middle Aged; Naloxone; Prolactin | 1982 |
Modulation of peripheral adrenergic neurotransmission by methionine-enkephalin.
Topics: Animals; Cats; Dopamine beta-Hydroxylase; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Morphine; Naloxone; Norepinephrine; Peripheral Nerves; Receptors, Opioid; Spleen; Sympathetic Nervous System; Synaptic Transmission | 1982 |
Analgesic activity of intracerebroventricular administration of morphiceptin and beta-casomorphins: correlation with the morphine (micro) receptor binding affinity.
Topics: Analgesia; Animals; Binding, Competitive; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Rats; Receptors, Opioid | 1982 |
The primate locus coeruleus and effects of clonidine on opiate withdrawal.
Topics: Animals; Behavior, Animal; Clonidine; Electric Stimulation; Enkephalins; Fear; Humans; Locus Coeruleus; Macaca; Morphine; Naloxone; Norepinephrine; Opioid-Related Disorders; Receptors, Opioid; Substance Withdrawal Syndrome | 1982 |
A multiplicity of opiate receptors and enkephalin neuronal systems.
Topics: Animals; Binding, Competitive; Brain; Brain Mapping; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Naloxone; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1982 |
Neuroblastoma X glioma hybrid cells synthesize enkephalin-like opioid peptides.
Topics: Alprostadil; Animals; Cell Line; Cyclic AMP; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Neuroblastoma; Oxidation-Reduction; Prostaglandins E; Rats | 1982 |
The binding of kappa- and sigma-opiates in rat brain.
Topics: Animals; Binding Sites; Brain; Culture Techniques; Cyclazocine; Dihydromorphine; Enkephalins; Ethylketocyclazocine; Ligands; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Tritium | 1982 |
Mammalian neuronal actions of FMRFamide and the structurally related opioid Met-enkephalin-Arg6-Phe7.
Topics: Action Potentials; Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; FMRFamide; Male; Medulla Oblongata; Naloxone; Neurons, Efferent; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
The effect of naloxone, morphine, and an enkephalin analogue on cholecystokinin octapeptide-stimulated gallbladder emptying.
Topics: Adult; Cholecystokinin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Gallbladder; Humans; Male; Morphine; Muscle Contraction; Naloxone; Peptide Fragments; Sincalide; Stimulation, Chemical; Ultrasonics | 1982 |
Peptidergic regulation of stress-induced eating.
Topics: Animals; Appetite Depressants; Atropine; Bombesin; Carbachol; Cholecystokinin; Enkephalin, Methionine; Enkephalins; Feeding Behavior; Haloperidol; Humans; Isoproterenol; Male; Muscimol; Naloxone; Norepinephrine; Peptide Fragments; Peptides; Phentolamine; Quipazine; Rats; Rats, Inbred Strains; Sincalide; Stress, Psychological | 1982 |
Reduction of opioid binding in neuroblastoma x glioma cells grown in medium containing unsaturated fatty acids.
Topics: Animals; Cell Line; Dihydromorphine; Enkephalins; Fatty Acids, Unsaturated; Kinetics; Membrane Fluidity; Membrane Lipids; Naloxone; Neurons; Rats; Receptors, Opioid | 1982 |
The choice of opiate receptor subtype by neo-endorphins.
Topics: Animals; Benzomorphans; beta-Endorphin; Cyclazocine; Drug Interactions; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid | 1982 |
Modulation of dopamine release in rat striatal slices by delta opiate agonists.
Topics: Animals; Corpus Striatum; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Tetrodotoxin | 1982 |
Endogenous opiates and pain.
Topics: Animals; Chemical Phenomena; Chemistry; Endorphins; Enkephalins; Guinea Pigs; Haplorhini; Humans; Mice; Naloxone; Pain; Pain Management; Rats; Receptors, Opioid | 1982 |
Nerve growth factor induces specific enkephalin binding sites in a nerve cell line.
Topics: Animals; beta-Endorphin; Cell Line; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Morphine; Naloxone; Nerve Growth Factors; Pheochromocytoma; Rats; Receptors, Opioid | 1982 |
Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Endorphins; Enkephalins; Histocytochemistry; Kinetics; Naloxone; Rats; Receptors, Opioid; Tissue Distribution; Tritium | 1982 |
Enhancement of delta- but not mu-opiate agonist binding by calcium.
Topics: Animals; Binding Sites; Brain; Calcium; Enkephalins; In Vitro Techniques; Kinetics; Magnesium; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Regulation of the in vitro antibody response by neuroendocrine hormones.
Topics: Adrenocorticotropic Hormone; Animals; Antibody Formation; beta-Endorphin; Cells, Cultured; Endorphins; Enkephalins; Female; Interferon Inducers; Kinetics; Lymphocytes; Mercaptoethanol; Mice; Mice, Inbred C57BL; Naloxone | 1982 |
beta-Endorphin enhances lymphocyte proliferative responses.
Topics: Analgesics; Animals; beta-Endorphin; Concanavalin A; DNA Replication; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Lymphocyte Activation; Lymphocytes; Male; Naloxone; Rats; Rats, Inbred Lew | 1982 |
Extreme hyperthermia induced in cats by the enkephalin analog FK 33-824.
Topics: Animals; Body Temperature Regulation; Cats; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Motor Activity; Naloxone; Receptors, Opioid; Shivering | 1982 |
Characterization of the opiate receptor in the guinea-pig ileal mucosa.
Topics: Animals; Diprenorphine; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Naloxone; Narcotics; Receptors, Opioid | 1982 |
Differential effect of humoral endorphin on the binding of opiate agonists and antagonists.
Topics: Animals; Binding Sites; Binding, Competitive; Cyclazocine; Endorphins; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Opioid; Sodium | 1982 |
Interplay between opioid peptides and pituitary hormones.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Cold Temperature; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Ether; Male; Naloxone; Pituitary Hormones; Pituitary-Adrenal System; Prolactin; Rats; Rats, Inbred Strains | 1982 |
Naltrexone-induced opiate receptor supersensitivity.
Topics: Animals; Brain; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Female; Guanosine Triphosphate; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Opiate and opioid peptide binding in rat goldfish: further evidence for opiate receptor heterogeneity.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Goldfish; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1982 |
Enkephalin analogue effects in the amygdala central nucleus on conditioned heart rate.
Topics: Amygdala; Animals; Conditioning, Classical; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Heart Rate; Naloxone; Rabbits; Receptors, Opioid | 1982 |
The effects of leucine-enkephalin on the spontaneous motility of the circular muscle of the cat colon.
Topics: Animals; Atropine; Cats; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Phentolamine; Receptors, Opioid; Tetrodotoxin | 1982 |
Opiatergic control of LH secretion is eliminated by gonadectomy.
Topics: Animals; Castration; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalins; Estradiol; Female; Hypothalamus; Luteinizing Hormone; Male; Naloxone; Organ Size; Rats; Rats, Inbred Strains; Receptors, Opioid; Testosterone; Time Factors | 1983 |
Dimeric pentapeptide enkephalin: a novel probe of delta opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Manganese; Naloxone; Radioligand Assay; Rats; Receptors, Opioid; Sodium | 1982 |
The epileptogenic spectrum of opiate agonists.
Topics: Animals; Anticonvulsants; beta-Endorphin; Cyclazocine; Electroencephalography; Endorphins; Enkephalin, Leucine; Epilepsy; Ethylketocyclazocine; Injections, Intraventricular; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains | 1982 |
Delta versus mu receptors: cardiovascular and respiratory effects of opiate agonists microinjected into nucleus tractus solitarius of cats.
Topics: Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Heart Rate; Injections, Intraventricular; Microinjections; Naloxone; Receptors, Opioid; Respiration | 1982 |
Ontogenesis of opiate binding sites and radioimmunoassayable beta-endorphin and enkephalin in regions of rat brain.
Topics: Aging; Animals; Animals, Newborn; beta-Endorphin; Brain; Endorphins; Enkephalins; Female; Kinetics; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Role of opioid peptides in brain mechanisms regulating blood pressure.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain; Endorphins; Enkephalins; Heart Rate; Hypertension; Male; Medulla Oblongata; Naloxone; Nociceptors; Pain; Rats; Sensory Thresholds | 1983 |
Interactions of leucine-enkephalin with alpha-adrenoceptors in the conscious dog.
Topics: Animals; Blood Pressure; Chemoreceptor Cells; Clonidine; Consciousness; Dogs; Enkephalin, Leucine; Heart Rate; Naloxone; Prazosin; Pressoreceptors; Propranolol; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Stimulation, Chemical | 1983 |
Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Enkephalins; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Naloxone; Protein Conformation; Rats; Receptors, Opioid; Vas Deferens | 1982 |
Opiate receptors and opioid peptides: an overview.
Topics: Animals; Brain; Dogs; Endorphins; Enkephalins; Guinea Pigs; Naloxone; Rats; Receptors, Opioid | 1982 |
Correlation of hydrophobic character of opioid peptides with their biological activity measured in various bioassay systems.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Solubility; Structure-Activity Relationship | 1982 |
The actions of [Leu5]enkephalin and morphine in cat sympathetic ganglion.
Topics: Animals; Cats; Enkephalin, Leucine; Female; Ganglia, Sympathetic; Male; Morphine; Naloxone; Synaptic Transmission | 1983 |
Interaction of naloxone with mu- and delta-opioid agonists on the respiration of rats.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotics; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Time Factors | 1983 |
Interaction of naloxone with the opioid receptor complex in vitro.
Topics: Animals; Brain; Enkephalin, Leucine; Kinetics; Male; Mathematics; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Pharmacological characterization of the opioid receptor in the submucous plexus of the guinea-pig oesophagus.
Topics: Acetylcholine; Animals; Electric Stimulation; Endorphins; Enkephalins; Esophagus; Guinea Pigs; In Vitro Techniques; Male; Morphine; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Naloxone; Receptors, Opioid | 1983 |
Peptide and non-peptide opioid-induced hyperthermia in rabbits.
Topics: Animals; beta-Endorphin; Body Temperature; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptides; Phenazocine; Rats | 1983 |
Dimeric pentapeptide and tetrapeptide enkephalins: new tools for the study of delta opioid receptors.
Topics: Animals; Cyclic AMP; Enkephalins; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Synthesis of porcine leumorphin and some of its biological activities.
Topics: Analgesia; Animals; beta-Endorphin; Biological Assay; Dynorphins; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; Ileum; Indicators and Reagents; Mice; Muscle Contraction; Naloxone; Narcotics; Peptide Fragments; Protein Precursors; Swine | 1983 |
Functional opiate receptor in mouse vas deferens: evidence for a complex interaction.
Topics: Animals; Arylsulfatases; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Sulfatases; Vas Deferens | 1983 |
The binding to rat brain homogenates of Mr2034, a universal opiate.
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphinans; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isomerism; Kinetics; Muscle Contraction; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1983 |
Parasympathetic ganglia: naloxone antagonizes inhibition by leucine-enkephalin and GABA.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Leucine; Evoked Potentials; Female; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Parasympathetic; Male; Naloxone; Neural Inhibition; Synaptic Transmission; Urinary Bladder | 1983 |
The spinal cord as a site of opioid effects on gastrointestinal transit in the mouse.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Stimulation, Chemical | 1983 |
Interaction of leucine enkephalin with (3H)naloxone binding in rat brain: evidence for an opioid receptor complex.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Leucine; Kinetics; Male; Naloxone; Osmolar Concentration; Protein Binding; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Opioid peptides with differential affinity for mu and delta receptors decrease sensory neuron calcium-dependent action potentials.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; In Vitro Techniques; Mice; Naloxone; Neurons, Afferent; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 1983 |
Naloxone-inaccessible sigma receptor in rat central nervous system.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalins; Ethylketocyclazocine; Kinetics; Naloxone; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord; Tissue Distribution | 1983 |
[Effect of brain membrane lyophilization on the properties of opiate receptors].
Topics: Animals; Enkephalin, Leucine; Free Radicals; Freeze Drying; Ligands; Male; Meninges; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Opiate binding sites in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Binding Sites; Brain; Brain Chemistry; Cattle; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Ligands; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Chronic ethanol alters the receptor binding characteristics of the delta opioid receptor ligand, D-Ala2-D-Leu5 enkephalin in mouse brain.
Topics: Alcoholism; Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Humans; Male; Mice; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1983 |
The involvement of opioid delta-receptors in stress induced antinociception in mice.
Topics: Animals; Enkephalin, Leucine; Escape Reaction; Male; Mice; Naloxone; Pain; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Swimming | 1983 |
Modulation of acid secretion from enriched guinea pig parietal cells by opioid receptors.
Topics: Animals; Binding Sites; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Acid; Guinea Pigs; In Vitro Techniques; Male; Naloxone; Parietal Cells, Gastric; Receptors, Opioid; Tritium | 1983 |
Computer-assisted analysis of receptor-binding studies of [3H]-naloxone and [3H]-DADL: a reinterpretation of the Na+ effect.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Naloxone; Rats; Receptors, Opioid; Sodium | 1983 |
Comparison of the action of putative endogenous kappa-agonists, leumorphin and rimorphin in vitro.
Topics: Animals; Biological Assay; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Vas Deferens | 1983 |
Detailed receptor binding studies of a series of N-substituted ethyl 3-arylnipecotates.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Naloxone; Nipecotic Acids; Rats; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1983 |
Evidence for delta-receptor involvement in the post-ictal antinociceptive responses to electroconvulsive shock in rats.
Topics: Animals; Electroshock; Enkephalin, Leucine; Escape Reaction; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Multiple opioid receptors: evidence for mu-delta binding site interactions in endotoxic shock.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Heart Rate; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pulse; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Shock, Septic | 1983 |
Comparison in the mouse of the effect of the opiate delta receptor antagonist ICI 154129 and naloxone in tests of extinction, passive avoidance and food intake.
Topics: Animals; Avoidance Learning; Enkephalin, Leucine; Extinction, Psychological; Feeding Behavior; Female; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Effect of digitonin on the binding of opiate agonists and antagonists to membrane-bound and soluble opioid binding sites.
Topics: Animals; Brain; Bufo marinus; Digitonin; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Species Specificity | 1984 |
ICI 154,129, a delta-opioid receptor antagonist raises seizure threshold in rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Brain enkephalin receptors in Parkinson's disease.
Topics: Aged; Brain; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Kinetics; Levodopa; Male; Naloxone; Nucleus Accumbens; Parkinson Disease; Receptors, Dopamine; Receptors, Opioid; Substantia Nigra | 1983 |
ICI 174864: a highly selective antagonist for the opioid delta-receptor.
Topics: Animals; Enkephalin, Leucine; Male; Mice; Muscle Contraction; Naloxone; Receptors, Opioid; Vas Deferens | 1984 |
Comparison of the influence of the opiate delta receptor antagonist, ICI 154,129, and naloxone on social interaction and behaviour in an open field.
Topics: Animals; Behavior, Animal; Enkephalin, Leucine; Interpersonal Relations; Male; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Detergent extraction from rat synaptosomal plasma membranes reveals difference in mu and delta opioid receptor binding.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Detergents; Enkephalins; In Vitro Techniques; Male; Naloxone; Proteins; Rats; Receptors, Opioid; Solubility; Surface-Active Agents; Synaptosomes | 1984 |
Role of enkephalins in regulation of basal intestinal water and ion absorption in the rat.
Topics: Animals; Atropine; Colon; Diprenorphine; Enkephalins; Intestine, Small; Male; Morphine; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Water-Electrolyte Balance | 1984 |
Differences in hypothalamo-pituitary-adrenocortical activity in the rat after acute and prolonged treatment with morphine.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Corticotropin-Releasing Hormone; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Morphine Dependence; Naloxone; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Stress, Physiological | 1984 |
Selective cardiorespiratory effects mediated by mu opioid receptors in the nucleus ambiguus.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Male; Medulla Oblongata; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Respiration, Artificial | 1984 |
Microelectrophoretic administration of naloxone near motoneurones fails to reproduce the effects of systemic naloxone in anaesthetized cats.
Topics: Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hindlimb; Membrane Potentials; Motor Neurons; Muscles; Naloxone; Neural Inhibition; Reflex, Stretch; Spinal Cord; Synaptic Transmission | 1984 |
A photoaffinity reagent to label the opiate receptors of guinea pig ileum and mouse vas deferens.
Topics: Affinity Labels; Animals; Azides; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Photochemistry; Receptors, Opioid; Vas Deferens | 1984 |
Differential role of the opioid mu and delta receptors in the activation of prolactin (PRL) and growth hormone (GH) secretion by morphine in the male rat.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Growth Hormone; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
The ontogeny of seizures induced by leucine-enkephalin and beta-endorphin.
Topics: Aging; Animals; beta-Endorphin; Brain; Electroencephalography; Endorphins; Enkephalin, Leucine; Evoked Potentials; Male; Naloxone; Rats; Rats, Inbred Strains; Seizures | 1984 |
A very high affinity opioid binding site in rat brain: demonstration by computer modeling.
Topics: Animals; Binding, Competitive; Brain Chemistry; Computers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Mathematics; Models, Chemical; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Effect of beta-casomorphins and analogs on insulin release in dogs.
Topics: Animals; Blood Glucose; Dogs; Endorphins; Enkephalins; Infusions, Parenteral; Insulin; Insulin Secretion; Kinetics; Naloxone; Structure-Activity Relationship | 1983 |
Long-term ethanol alters the binding of 3H-opiates to brain membranes.
Topics: Animals; Brain; Cell Membrane; Dihydromorphine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Male; Morphine Derivatives; Naloxone; Rats; Rats, Inbred Strains | 1983 |
Studies on the role of opiate peptides in two forms of genetic obesity: ob/ob mouse and fa/fa rat.
Topics: Animals; Chromatography; Digestive System; Endorphins; Enkephalin, Leucine; Fasting; In Vitro Techniques; Insulin; Insulin Secretion; Male; Mice; Mice, Obese; Naloxone; Obesity; Pancreas; Radioimmunoassay; Radioligand Assay; Rats; Rats, Zucker; Tissue Distribution; Tissue Extracts | 1983 |
Analgesia induced by intrathecal injection of dynorphin B in the rat.
Topics: Analgesics; Animals; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Female; Injections, Spinal; Morphine; Naloxone; Rats | 1984 |
Effect of enkephalin and naloxone on vagal and hormonal stimulation of pancreatic secretion in man.
Topics: Adult; Bicarbonates; Enkephalin, Leucine-2-Alanine; Enkephalins; Food; Gastric Acid; Gastrins; Humans; Male; Naloxone; Pancreas; Proteins; Secretin | 1983 |
Effect of intrahypothalamic injection of [D-Ala2,D-Leu5]enkephalin on feeding and temperature in the rat.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Hypothalamus; Injections, Intraventricular; Male; Morphine; Naloxone; Phentolamine; Rats; Rats, Inbred Strains | 1983 |
Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats.
Topics: Analgesics; Animals; Benzomorphans; Catatonia; Constipation; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Gastrointestinal Motility; Humans; Male; Morphinans; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Inhibitors of an enkephalin degrading membrane-bound metalloendopeptidase: analgesic properties and effects on striatal enkephalin levels.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Analgesics; Animals; Corpus Striatum; Dipeptides; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Membranes; Naloxone; Neprilysin; para-Aminobenzoates; Protease Inhibitors; Radioimmunoassay; Rats; Rats, Inbred Strains | 1984 |
Stereospecific inhibition by naloxone of histamine-stimulated acid secretion in isolated guinea pig parietal cells.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Acid; Guinea Pigs; Histamine; In Vitro Techniques; Male; Naloxone; Parietal Cells, Gastric; Stereoisomerism | 1984 |
Pharmacological analysis of shaking behavior induced by enkephalins, thyrotropin-releasing hormone or serotonin in rats: evidence for different mechanisms.
Topics: Animals; Behavior, Animal; Brain Chemistry; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Thyrotropin-Releasing Hormone | 1983 |
Effect of enkephalin and naloxone on gastric acid and serum gastrin and pancreatic polypeptide concentrations in humans.
Topics: Adult; Dose-Response Relationship, Drug; Enkephalins; Food; Gastric Acid; Gastrins; Histamine; Humans; Male; Naloxone; Pancreatic Polypeptide; Pentagastrin; Pepsin A; Secretory Rate; Vagus Nerve | 1983 |
Opiate inhibition of K+-induced TRH release from superfused mediobasal hypothalami in rats.
Topics: Animals; Enkephalin, Leucine; Hypothalamus; In Vitro Techniques; Male; Morphine; Naloxone; Potassium; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1983 |
Opioid peptides and self-stimulation of the medial prefrontal cortex in the rat.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Injections, Intraventricular; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Self Stimulation | 1984 |
Behavioral and EEG effects of synthetic enkephalin analogue (FK 33-824).
Topics: Amygdala; Animals; Behavior, Animal; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electroencephalography; Endorphins; Enkephalins; Fenclonine; Hypnotics and Sedatives; Naloxone; Rabbits | 1980 |
[Effect of enkephalins on vasopressin and aldosterone levels in acute experimental myocardial ischemia].
Topics: Aldosterone; Animals; Coronary Disease; Diuresis; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Rats; Vasopressins | 1984 |
[Levels of prolactin and growth hormone after administration enkephalin analogs in rats].
Topics: Animals; Enkephalins; Growth Hormone; Male; Morphine; Naloxone; Prolactin; Rats | 1984 |
Effects of Leu5-enkephalin on natural and angiotensin II-induced drinking in the Japanese quail (Coturnix coturnix japonica).
Topics: Angiotensin II; Animals; Brain; Coturnix; Drinking; Enkephalin, Leucine; Injections; Injections, Intravenous; Male; Naloxone; Quail | 1984 |
Enkephalin content in rat striatum during prolonged treatment with fluphenazine.
Topics: Animals; Apomorphine; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fluphenazine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1984 |
Analgesic effect of histamine induced by intracerebral injection into mice.
Topics: Analgesics; Animals; Benzoquinones; Cimetidine; Diphenhydramine; Electric Stimulation; Enkephalin, Leucine; Histamine; Histamine Antagonists; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Promethazine; Pyrilamine; Quinones; Reaction Time | 1984 |
Leucine-enkephalin modulation of catecholamine positive chronotropy in rat atria is receptor-specific and calcium-dependent.
Topics: Animals; Calcium; Catecholamines; Colforsin; Diterpenes; Enkephalin, Leucine; Heart; Heart Rate; Isoproterenol; Male; Naloxone; Norepinephrine; Rats; Receptors, Adrenergic | 1984 |
Effect of enkephalin on the micturition cycle of the cat.
Topics: Animals; Brain Stem; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Spinal Cord; Urinary Bladder; Urination | 1984 |
Activation of nucleus raphe magnus by acupuncture and enkephalinergic mechanism.
Topics: Acupuncture Therapy; Animals; Endorphins; Enkephalins; Iontophoresis; Male; Naloxone; Neurons; Periaqueductal Gray; Raphe Nuclei; Rats | 1984 |
Effect of opiates on human colonic adenylate cyclase activity.
Topics: Adenylyl Cyclases; Calcium; Colon; Dinoprostone; Enkephalins; Humans; In Vitro Techniques; Morphine; Muscle, Smooth; Naloxone; Narcotics; Prostaglandins E; Sodium Fluoride; Vasopressins | 1983 |
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test.
Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
The inhibitory effect of opioid peptides and morphine applied intrathecally and intracerebroventricularly on the micturition reflex in the cat.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Morphine; Naloxone; Oligopeptides; Reflex; Thiorphan; Tiopronin; Urination | 1984 |
Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin.
Topics: alpha-Methyltyrosine; Amino Acids, Sulfur; Aminopeptidases; Animals; Biogenic Amines; Brain; Enkephalins; Leucine; Male; Methyltyrosines; Mice; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
Effect of morphine and leucine-enkephalin on the electrophysiological responses of Pacinian corpuscles of the cat.
Topics: Animals; Cats; Electrophysiology; Enkephalin, Leucine; Mechanoreceptors; Morphine; Naloxone; Pacinian Corpuscles | 1983 |
The stinging response of the honeybee: effects of morphine, naloxone and some opioid peptides.
Topics: Animals; Bees; Behavior, Animal; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Insect Bites and Stings; Morphine; Naloxone | 1983 |
[Effects of haloperidol pretreatment on the release of enkephalins by electrical stimulation in the isolated guinea pig ileum].
Topics: Animals; Electric Stimulation; Enkephalins; Female; Guinea Pigs; Haloperidol; Ileum; Male; Naloxone | 1983 |
Leucine enkephalin antagonizes norepinephrine-induced 45Ca++ accumulation in rat atria.
Topics: Animals; Calcium; Enkephalin, Leucine; Female; Heart; Heart Atria; Male; Myocardium; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Comparison of naloxone and a delta-selective antagonist in experimental spinal stroke.
Topics: Animals; Cerebrovascular Disorders; Disease Models, Animal; Enkephalin, Leucine; Male; Motor Activity; Naloxone; Rabbits; Spinal Cord | 1983 |
[Effect of opiates on the rat vas deferens].
Topics: Animals; Cyclazocine; Enkephalins; Male; Morphine; Muscle Contraction; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Vas Deferens | 1983 |
Physical dependence-producing properties of tetrapeptide acylhydrazide analogs of enkephalin in rats.
Topics: Animals; Body Weight; Enkephalins; Humans; Male; Morphine; Naloxone; Pentazocine; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1983 |
Catatonic or hypotonic immobility induced in mice by intracerebroventricular injection of mu or kappa opioid receptor agonists as well as enkephalins or inhibitors of their degradation.
Topics: Animals; Benzomorphans; Catatonia; Cyclazocine; Enkephalins; Ethylketocyclazocine; Fentanyl; Humans; Immobilization; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics | 1983 |
Simultaneous measurement of cholecystokinin- and vasoactive intestinal polypeptide-like immunoreactivity from cat frontal cortex in vitro: effect of morphine and D-Ala2-D-Leu5-enkephalin.
Topics: Animals; Cats; Cholecystokinin; Dextrorphan; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Levorphanol; Morphine; Naloxone; Potassium; Vasoactive Intestinal Peptide | 1984 |
Leu-enkephalin provokes naloxone-insensitive pulmonary vasoconstriction.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Lung; Male; Methysergide; Morphine; Naloxone; Pyrilamine; Rats; Rats, Inbred Strains; Vasoconstriction | 1984 |
Opposite effects of Met-enkephalin and Leu-enkephalin on a discriminated shock-escape task.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Escape Reaction; Male; Mice; Motor Activity; Naloxone | 1984 |
In vitro and in vivo effects of thiorphan: an inhibitor of enkephalinase A.
Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesics; Animals; Captopril; Drug Synergism; Enkephalins; In Vitro Techniques; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin | 1982 |
Pharmacological characterization of opioid effects in the rat hippocampal slice.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Hippocampus; In Vitro Techniques; Morphine; Naloxone; Narcotics; Pyramidal Tracts; Rats; Synapses | 1982 |
Peptidergic (enkephalin) innervation of the mammalian esophagus.
Topics: Adrenergic Fibers; Animals; Autonomic Agents; Cats; Cholinergic Fibers; Endorphins; Enkephalins; Esophagus; Fetus; Guinea Pigs; Haplorhini; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Opossums; Swine; Tetrodotoxin | 1980 |
Effects of morphine and naloxone on phasic release of luteinizing hormone and follicle-stimulating hormone.
Topics: Animals; Castration; Enkephalins; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Hypothalamus, Anterior; Luteinizing Hormone; Morphine; Naloxone; Neurons; Ovulation; Pituitary Gland; Preoptic Area; Progesterone; Rats | 1980 |
Effects of thyrotrophin-releasing hormone, and methionine-enkephalin on gastric acid and pepsin secretion in the cat.
Topics: Animals; Blood Glucose; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Gastric Juice; Insulin; Naloxone; Pentagastrin; Pepsin A; Thyrotropin-Releasing Hormone; Time Factors | 1980 |
The role of the nucleus accumbens and nigrostriatum in enkephalin-induced myoclonus.
Topics: Animals; Brain; Corpus Striatum; Electroencephalography; Electromyography; Enkephalins; Epilepsies, Myoclonic; Haloperidol; Male; Naloxone; Nucleus Accumbens; Rats; Septal Nuclei; Substantia Nigra | 1980 |
Inhibitory actions of methionine-enkephalin and morphine on the cat carotid chemoreceptors.
Topics: Acetylcholine; Animals; Carbon Dioxide; Carotid Sinus; Cats; Chemoreceptor Cells; Cyanides; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Morphine; Naloxone | 1980 |
(D-Met2,Pro5)-enkephalinamide-induced blockade of ovulation and its reversal by naloxone in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Estrus; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Naloxone; Ovulation; Pregnancy; Rats | 1981 |
Characterization of the respiratory activity of (D-Ala2)methionine-enkephalinamide.
Topics: Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Rats; Respiration; Respiratory Center; Time Factors | 1981 |
Effects of an enkephalin analogue (DAMME) on insulin release from cultured rat islets of Langerhans.
Topics: Animals; Cells, Cultured; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Glucose; Growth Hormone-Releasing Hormone; Insulin; Islets of Langerhans; Naloxone; Rats; Trifluoperazine | 1981 |
Y-maze behavior in the mouse after morphine or an enkephalin analog.
Topics: Animals; Endorphins; Enkephalins; Male; Mice; Morphine; Motor Activity; Naloxone | 1981 |
Increased food and water intake produced in rats by opiate receptor agonists.
Topics: Animals; Cyclazocine; Drinking; Drug Interactions; Eating; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Narcotics; Rats | 1981 |
Effects of naloxone on carotid body chemoreception and ventilation in the cat.
Topics: Animals; Carbon Dioxide; Carotid Body; Cats; Chemoreceptor Cells; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Oxygen; Respiration; Tidal Volume | 1981 |
Endogenous opioid poisoning?
Topics: Aged; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Naloxone; Respiratory Insufficiency | 1982 |
Effect of a met-enkephalin analogue and naloxone infusion on gonadotrophin secretion in man.
Topics: Adult; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Female; Follicle Stimulating Hormone; Hormones; Humans; Luteinizing Hormone; Male; Menopause; Middle Aged; Naloxone | 1981 |
Analysis of the 2-deoxy-D-glucose-induced vagal stimulation of gastric secretion and gastrin release in dogs using methionine-enkephalin, morphine and naloxone.
Topics: Animals; Bethanechol Compounds; Deoxy Sugars; Deoxyglucose; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Gastric Acid; Gastrins; Male; Morphine; Naloxone; Pepsin A; Stimulation, Chemical; Vagus Nerve | 1982 |
Peptides, the pineal gland and thermoregulation.
Topics: Animals; Body Temperature Regulation; Cyprinidae; Endorphins; Enkephalin, Methionine; Enkephalins; Goldfish; Naloxone; Peptides; Pineal Gland; Thyrotropin-Releasing Hormone | 1982 |
[Implication of enkephalins in central cardiovascular regulation in the rat].
Topics: Animals; Autonomic Nervous System; Blood Pressure; Diprenorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Heart Rate; Hypertension; Injections, Spinal; Naloxone; Oxygen; Rats; Rats, Inbred Strains; Respiration | 1982 |
Modification of endorphin/enkephalin analgesia and stress-induced analgesia by divalent cations, a cation chelator and an ionophore.
Topics: Acetates; Analgesia; Animals; Calcimycin; Calcium; Egtazic Acid; Endorphins; Enkephalins; Ethylene Glycols; Male; Manganese; Mice; Mice, Inbred ICR; Naloxone; Stress, Physiological | 1982 |
Enkephalins modulate [3H]dopamine release from rabbit retina in vitro.
Topics: Animals; Calcium; Dopamine; Enkephalins; In Vitro Techniques; Morphine; Naloxone; Rabbits; Retina | 1983 |
Synthesis and evaluation of 1- and 2-substituted fentanyl analogues for opioid activity.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Morphine; Naloxone; Vas Deferens | 1983 |
Stereospecific enhancement of evoked release of brain acetylcholine by narcotic antagonists.
Topics: Acetylcholine; Animals; Brain; Electric Stimulation; Enkephalins; Hypophysectomy; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Stereoisomerism | 1983 |
[Selective reduction by morphine and enkephalins of depolarization induced by application of dopamine to Helix pomatia neurons].
Topics: Acetylcholine; Animals; Dopamine Antagonists; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia; Helix, Snails; In Vitro Techniques; Morphine; Naloxone; Neurons | 1983 |
Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat.
Topics: Animals; Choice Behavior; Drinking Behavior; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Saccharin | 1983 |
Central representation and opioid modulation of gastric mechanoreceptor activity in the rat.
Topics: Action Potentials; Animals; Brain; Enkephalin, Leucine; Iontophoresis; Mechanoreceptors; Naloxone; Rats; Stomach; Vagus Nerve | 1983 |
Tolerance to morphine bradycardia in the rat.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains | 1983 |
Direct pituitary stimulation of thyrotropin secretion by opioid peptides.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; In Vitro Techniques; Kinetics; Male; Naloxone; Narcotics; Peptide Fragments; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thyrotropin | 1983 |
Effects of Met-enkephalin and naloxone on gastric emptying and secretion in rhesus monkeys.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gastric Emptying; Gastric Juice; Hydrogen-Ion Concentration; Macaca mulatta; Male; Naloxone | 1983 |
Behavioral and electrographic effects of opioids on kindled seizures in rats.
Topics: Animals; Behavior, Animal; Drug Tolerance; Enkephalins; Guinea Pigs; Humans; Kindling, Neurologic; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Seizures; Substance Withdrawal Syndrome; Vas Deferens | 1982 |
Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7.
Topics: Analgesics; Animals; Diarrhea; Diuresis; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Naloxone; Rats | 1980 |
Brain endorphins: possible role in long-term memory.
Topics: Animals; Avoidance Learning; Endorphins; Enkephalins; Male; Memory; Morphine; Naloxone; Rats; Retention, Psychology | 1982 |
Opiate peptides, analgesia, and the neuroendocrine system.
Topics: Acupuncture Therapy; Analgesia; Animals; Carcinoid Tumor; Electric Stimulation Therapy; Endorphins; Enkephalins; Humans; Mental Disorders; Naloxone; Rats; Substance Withdrawal Syndrome | 1980 |
Failure of naloxone to reverse analgesia from transcutaneous electrical stimulation in patients with chronic pain.
Topics: Adult; Analgesia; Double-Blind Method; Electric Stimulation Therapy; Endorphins; Enkephalins; Female; Humans; Male; Middle Aged; Naloxone; Pain, Intractable | 1981 |
Naloxone blocks the effect of 5-hydroxy-tryptophan on passive avoidance learning in rats: implication of endogenous opiod peptides.
Topics: 5-Hydroxytryptophan; Animals; Avoidance Learning; Behavior, Animal; Clorgyline; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Rats; Serotonin | 1981 |
Evidence for vagal enkephalinergic neural control of the feline pylorus and stomach.
Topics: Animals; Atropine; Blood Pressure; Cats; Electric Stimulation; Endorphins; Enkephalins; Female; Fluorescent Antibody Technique; Gastrointestinal Motility; Male; Morphine; Naloxone; Pyloric Antrum; Pylorus; Stomach; Vagus Nerve | 1980 |
Disparate effects of enkephalin and morphine upon insulin and glucagon secretion by islet cell cultures.
Topics: Animals; Animals, Newborn; Cells, Cultured; Depression, Chemical; Endorphins; Enkephalins; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Morphine; Naloxone; Rats | 1980 |
Studies off the opiate control of prolactin, GH and TSH.
Topics: Adolescent; Adult; Blood Glucose; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Female; Growth Hormone; Hormones; Humans; Insulin; Male; Naloxone; Prolactin; Thyrotropin | 1981 |
Effects of intraventricular morphine and enkephalins on locomotor activity in nondependent, morphine-dependent and postdependent rats.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Rats; Time Factors | 1981 |
The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.
Topics: Animals; Behavior, Animal; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flupenthixol; Globus Pallidus; Male; Motor Activity; Naloxone; Organ Specificity; Rats; Tegmentum Mesencephali | 1981 |
Possible mechanisms of enkephalin action on hippocampal CA1 pyramidal neurons.
Topics: Animals; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Naloxone; Neurons; Pyramidal Tracts; Rats; Synapses | 1981 |
Inhibition of dopamine biosynthesis by gonadotropin-releasing hormone in rat.
Topics: Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Gonadotropin-Releasing Hormone; Naloxone; Rats; Synaptosomes | 1982 |
Effect of naloxone on met-enkephalin-induced gastric acid secretion and serum gastrin in man.
Topics: Adult; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Gastric Acid; Gastrins; Humans; Male; Middle Aged; Naloxone; Pentagastrin | 1982 |
Opiate alkaloids antagonize postsynaptic glycine and GABA responses: correlation with convulsant action.
Topics: Animals; Cells, Cultured; Dextrorphan; Enkephalin, Methionine; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Levorphanol; Mice; Morphine; Naloxone; Narcotics; Neural Inhibition; Neurons; Seizures; Spinal Cord; Synapses | 1982 |
Opioid peptides and blood pressure regulation.
Topics: Animals; Blood Pressure; Brain; Endorphins; Enkephalins; Humans; Naloxone; Shock, Hemorrhagic | 1982 |
Leucine-enkephalin: reversal of intrinsic cardiovascular stimulation by pentobarbital.
Topics: Anesthesia; Animals; Dogs; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalins; Hemodynamics; Naloxone; Pentobarbital; Respiration | 1982 |
Methionine enkephalin increases CNS suppressive control exerted over gill reflex behaviours and associated neural activity in Aplysia california.
Topics: Action Potentials; Animals; Aplysia; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Gills; Motor Neurons; Naloxone; Reflex | 1982 |
Effect of methionine-enkephalin and naloxone on bombesin-stimulated gastric acid secretion, gastrin, and pancreatic polypeptide release in the dog.
Topics: Animals; Bombesin; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Gastric Acid; Gastrins; Infusions, Parenteral; Naloxone; Pancreatic Polypeptide; Peptides; Stimulation, Chemical; Time Factors | 1982 |
Opioid peptides decrease calcium-dependent action potential duration of mouse dorsal root ganglion neurons in cell culture.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Endorphins; Enkephalin, Leucine; Enkephalins; Fetus; Ganglia, Spinal; Kinetics; Mice; Naloxone; Neurons | 1982 |
Reward produced by microinjection of (D-Ala2),Met5-enkephalinamide into the ventral tegmental area.
Topics: Animals; Conditioning, Operant; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Rats; Reward; Tegmentum Mesencephali | 1982 |
The effect of naloxone on opioid-induced inhibition and facilitation of acetylcholine release in brain slices.
Topics: Acetylcholine; Animals; Brain; Calcium; Caudate Nucleus; Cerebral Cortex; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Naloxone; Narcotics; Thalamus | 1982 |
Morphine allosterically modulates the binding of [3H]leucine enkephalin to a particulate fraction of rat brain.
Topics: Allosteric Site; Animals; Brain; Buffers; Diprenorphine; Endorphins; Enkephalin, Leucine; Enkephalins; Female; In Vitro Techniques; Kinetics; Models, Biological; Morphine; Naloxone; Rats; Rats, Inbred Strains; Subcellular Fractions; Time Factors | 1982 |
Effect of hemorrhagic shock on the concomitant release of endorphin and enkephalin-like peptides from the pituitary and adrenal gland in the dog.
Topics: Adrenal Glands; Animals; Dogs; Endorphins; Enkephalins; Naloxone; Pituitary Gland; Shock; Shock, Hemorrhagic | 1982 |
Kyotorphin (L-Tyr-L-Arg) inhibits extinction of pole-jumping avoidance response in the rat.
Topics: Animals; Avoidance Learning; Endorphins; Enkephalin, Leucine; Extinction, Psychological; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Effects of enkephalins on perfusion pressure in isolated hindlimb preparations.
Topics: Animals; Blood Pressure; Cats; Diphenhydramine; Dose-Response Relationship, Drug; Drug Antagonism; Enkephalin, Leucine; Enkephalin, Methionine; Female; Femoral Artery; In Vitro Techniques; Injections, Intra-Arterial; Male; Naloxone; Perfusion; Propranolol; Vasodilation | 1982 |
Endorphin mediation of post-ictal effects of kindled seizures in rats.
Topics: Amygdala; Animals; Enkephalins; Globus Pallidus; Kindling, Neurologic; Male; Naloxone; Rats; Rats, Inbred Strains; Reflex; Seizures | 1982 |
Opiate mechanisms in the regulation of the cardiovascular system.
Topics: Animals; Cats; Clonidine; Enkephalins; Hemodynamics; Hypertension; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Maturational effect of enkephalin on respiratory control in newborn rabbits.
Topics: Animals; Animals, Newborn; Enkephalins; Naloxone; Rabbits; Respiration; Respiratory System; Vagus Nerve | 1982 |
Development of acute opioid tolerance and dependence in rat striatal neurones.
Topics: Animals; Corpus Striatum; Drug Tolerance; Enkephalins; Glutamates; Humans; Male; Naloxone; Narcotics; Neurons; Opioid-Related Disorders; Rats | 1980 |
Enkephalin analogs and physical dependence.
Topics: Animals; Avoidance Learning; Drug Implants; Endorphins; Enkephalins; Heart Rate; Humans; Male; Naloxone; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1981 |
Retrograde amnesia caused by Met-, Leu- and des-Try-Met-enkephalin in the rat and its reversal by naloxone.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Drug Antagonism; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; Kinetics; Naloxone; Rats | 1981 |
The effect of naloxone on enkephalin catabolism.
Topics: Aminopeptidases; Animals; Biotransformation; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Male; Mice; Morphine Dependence; Naloxone; Protease Inhibitors | 1981 |
Pharmacological characterization of opiate physical dependence in the isolated ileum of the guinea-pig.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Levorphanol; Male; Morphine; Nalorphine; Naloxone; Narcotics; Pentazocine; Substance-Related Disorders; Time Factors | 1981 |
The role of the pituitary in the diurnal variation in tolerance to painful stimuli and brain enkephalin levels.
Topics: Animals; Brain; Circadian Rhythm; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Hypophysectomy; Male; Mice; Naloxone; Pain; Pituitary Gland; Prolactin; Rats; Stress, Psychological | 1981 |
Contraversive circling and facilitation of the perioral biting reflex by injection of substance P or D-Ala2-Met-encephalinamide into the substantia nigra.
Topics: Animals; Appetitive Behavior; Dominance, Cerebral; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Male; Muscimol; Naloxone; Predatory Behavior; Rats; Rats, Inbred Strains; Reflex; Stereotyped Behavior; Substantia Nigra | 1982 |
Spreading depression induced by microinjection of enkephalins into the hippocampus and neocortex.
Topics: Animals; Cerebral Cortex; Cortical Spreading Depression; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hippocampus; Male; Membrane Potentials; Naloxone; Rats | 1981 |
Peristalsis abolishes the release of methionine-enkephalin from guinea-pig ileum in vitro.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Naloxone; Peristalsis | 1981 |
Opiate regulation of angiotensin-induced drinking and vasopressin release.
Topics: Angiotensin II; Animals; Drinking; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Saralasin; Vasopressins | 1981 |
Morphine and delta-opiate agonists locally stimulate in vivo dopamine release in cat caudate nucleus.
Topics: Animals; Cats; Caudate Nucleus; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Morphine; Naloxone | 1981 |
Pupillary effects of leucine and methionine enkephalin in rats after intraperitoneal administration.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Morphine; Naloxone; Pupil; Rats; Structure-Activity Relationship | 1980 |
Evidence for an action of morphine and the enkephalins on sensory nerve endings in the mouse peritoneum.
Topics: Analgesics; Animals; Atropine; Drug Interactions; Drug Tolerance; Endorphins; Enkephalins; Female; Male; Mice; Morphine; Naloxone; Nerve Endings; Neurons, Afferent; Papaverine; Peritoneum | 1981 |
A comparison of the anticonvulsant effects of two systemically active enkephalin analogues in rats.
Topics: Animals; Anticonvulsants; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Flurothyl; Male; Naloxone; Rats; Seizures | 1981 |
Demonstration and characterization of opiate inhibition of the striatal adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Animals; Chlorides; Corpus Striatum; Endorphins; Enkephalin, Leucine; Enkephalins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Male; Manganese; Manganese Compounds; Naloxone; Rats; Sodium Chloride; Sodium Fluoride; Stereoisomerism | 1981 |
Effect of methionine-enkephalin on xanthopore aggregation.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Goldfish; Melatonin; Naloxone; Skin; Skin Physiological Phenomena | 1980 |
Effects of intravenously administered Leu- or Met-enkephalin on arterial blood pressure.
Topics: Animals; Blood Pressure; Cats; Diphenhydramine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Injections, Intravenous; Male; Naloxone; Propranolol | 1980 |
Transient apnea after an enkephalin analogue in the preterm rabbit.
Topics: Animals; Animals, Newborn; Apnea; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Female; Naloxone; Pregnancy; Rabbits | 1981 |
Opiate antagonists and agonists and feeding in sheep.
Topics: Animals; Dipeptides; Drinking; Drug Interactions; Endorphins; Enkephalins; Feeding Behavior; Male; Naloxone; Narcotic Antagonists; Sheep; Water Deprivation | 1981 |
Possible involvement of gamma-aminobutyric acid in growth hormone release induced by a Met5-enkephalin analog in conscious rats.
Topics: Animals; Bicuculline; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; gamma-Aminobutyric Acid; Growth Hormone; Hormones; Kinetics; Male; Naloxone; Picrotoxin; Rats; Rats, Inbred Strains | 1981 |
Enkephalins induce asymmetrical effects on posture in the rat.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Functional Laterality; Hindlimb; Male; Naloxone; Phosphorylases; Posture; Rats; Spinal Cord | 1981 |
The lipolytic activity of met-enkephalin, leu-enkephalin, morphine, methadone and naloxone in human adipose tissue.
Topics: Adipose Tissue; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fatty Acids, Nonesterified; Female; Humans; Lipolysis; Male; Methadone; Naloxone | 1981 |
Enkephalin-induced inhibition of the isolated rat ileum is not blocked by naloxone.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Rats, Inbred Strains | 1981 |
[Possible mechanisms of peripheral stimulation analgesia. Neurophysiologic and neuropharmacologic studies].
Topics: Acupuncture Therapy; Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Naloxone; Nociceptors | 1981 |
Differential effects of enkephalin within hippocampal areas.
Topics: Animals; Bicuculline; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hippocampus; In Vitro Techniques; Naloxone; Neurons; Rats | 1981 |
Strain dependent effects of the enkephalin analogue FK 33-824 on locomotor activity in mice.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Interactions; Drug Tolerance; Endorphins; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Species Specificity | 1981 |
[Inhibitory effect of methionine enkephalin and morphine on pentagastrin-stimulated gastric secretion in dogs].
Topics: Animals; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Gastric Mucosa; Morphine; Naloxone; Pentagastrin | 1981 |
A new technique for the in vivo bioassay of opiates and other drugs on mouse spinal cord.
Topics: Animals; Biological Assay; Endorphins; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Spinal Cord | 1981 |
Enkephalin-related peptides: direct action on the octopus heart.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Heart; Heart Rate; Male; Naloxone; Octopodiformes | 1981 |
Enhanced analgesic activity of liposomised Met-enkephalin analogue.
Topics: Analgesia; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Liposomes; Mice; Naloxone | 1981 |
Endogenous morphines and pain.
Topics: Animals; Behavior, Animal; Brain; Endorphins; Enkephalins; Morphine; Naloxone; Pain; Rats | 1981 |
Inhibition of sialoglycosphingolipid (ganglioside) biosynthesis in mouse clonal lines N4TG1 and NG108-15 by beta-endorphin, enkephalins, and opiates.
Topics: Animals; Cell Line; Endorphins; Enkephalins; Galactosamine; Galactose; Gangliosides; Glioma; Glucosamine; Glycosphingolipids; Hybrid Cells; Kinetics; Mice; Morphine; Naloxone; Narcotics; Neuroblastoma | 1980 |
Electrophysiological interactions of enkephalins with neuronal circuitry in the rat hippocampus. I. Effects on pyramidal cell activity.
Topics: Animals; Endorphins; Enkephalins; Evoked Potentials; Hippocampus; Hypoxia; In Vitro Techniques; Male; Naloxone; Neurons; Picrotoxin; Pyramidal Tracts; Rats | 1980 |
Asthma induced by enkephalin.
Topics: Asthma; Chlorpropamide; Drug Synergism; Enkephalins; Ethanol; Forced Expiratory Volume; Humans; Male; Middle Aged; Naloxone | 1980 |
Effect of morphine and naloxone on leu-enkephalin-like immunoreactivity in dogs.
Topics: Animals; Chromatography, Thin Layer; Cross Reactions; Dogs; Enkephalin, Leucine; Enkephalins; Femoral Artery; Hepatic Veins; Jugular Veins; Morphine; Naloxone; Portal Vein; Radioimmunoassay | 1980 |
Enkephalin inhibits the release and action of secretin on pancreatic secretion in the dog.
Topics: Animals; Bicarbonates; Cholecystokinin; Dogs; Endorphins; Enkephalins; Methionine; Naloxone; Pancreas; Proteins; Secretin; Secretory Rate | 1980 |
Enkephalins interfere with acquisition of an active avoidance response.
Topics: Animals; Avoidance Learning; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalins; Male; Mice; Naloxone; Time Factors | 1980 |
Effects of morphine and naloxone on the K+-stimulated release of methionine-enkephalin from slices of rat corpus striatum.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Feedback; Male; Morphine; Naloxone; Potassium; Rats | 1980 |
Self-administration of D-Ala2-Met-enkephalinamide at hypothalamic self-stimulation sites.
Topics: Animals; Dextrorphan; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Hypothalamus; Levallorphan; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Rats; Self Stimulation | 1980 |
Effects of different opiate agonists on melanocyte-stimulating hormone release: in vivo and in vitro studies.
Topics: Animals; Endorphins; Enkephalins; In Vitro Techniques; Male; Melanocyte-Stimulating Hormones; Naloxone; Pituitary Gland; Rats | 1980 |
The effect of (D-Ala2)-Met-enkephalin on the contraction of nictitating membrane in cats.
Topics: Animals; Cats; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Morphine; Muscle Contraction; Naloxone; Nictitating Membrane; Norepinephrine; Sympathetic Nervous System | 1980 |
beta-Endorphin and met-enkephalins: their distribution, modulation by estrogens and haloperidol, and role in neuroendocrine control.
Topics: Animals; Brain; Brain Chemistry; Castration; Endorphins; Enkephalins; Estrogens; Female; Growth Hormone; Haloperidol; Male; Naloxone; Prolactin; Rats; Secretory Rate | 1980 |
Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Locus Coeruleus; Membrane Potentials; Morphine Derivatives; Naloxone; Neurons | 1980 |
Interaction of amphetamine and naloxone in feeding behavior in guinea pigs.
Topics: Amphetamine; Animals; Brain Chemistry; Drinking; Drug Implants; Drug Interactions; Drug Tolerance; Endorphins; Enkephalins; Feeding Behavior; Guinea Pigs; Male; Naloxone | 1980 |
[A radioreceptor-assay of a methionine-enkephalin-like substance in human CSF (author's transl)].
Topics: Animals; Dihydromorphine; Endorphins; Enkephalins; Humans; Male; Methionine; Naloxone; Radioligand Assay; Rats | 1980 |
Cardiovascular effects of peptides related to the enkephalins and beta-casomorphin.
Topics: Animals; Atropine; Blood Pressure; Caseins; Endorphins; Enkephalins; Heart Rate; Humans; Male; Naloxone; Peptides; Rats; Structure-Activity Relationship | 1980 |
Are the enkephalins involved in Parkinson's disease? Clinical and neuroendocrine response to naloxone administration.
Topics: Aged; Endorphins; Enkephalins; Female; Humans; Male; Middle Aged; Naloxone; Parkinson Disease; Prolactin; Time Factors | 1980 |
Enkephalins affect hippocampal membrane phosphorylation.
Topics: Animals; Cell Membrane; Endorphins; Enkephalins; Etorphine; Hippocampus; In Vitro Techniques; Male; Membranes; Mitochondria; Molecular Weight; Naloxone; Phosphorylation; Rats; Synaptosomes | 1980 |
Enkephalin mydriasis in mice.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Mydriatics; Naloxone; Phenylalanine | 1980 |
Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin.
Topics: Aging; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Luteinizing Hormone; Male; Morphine; Naloxone; Rats; Testosterone | 1980 |
Hyper-endorphin syndrome in a child with necrotizing encephalomyelopathy.
Topics: Ataxia; Brain; Brain Chemistry; Brain Diseases; Cerebrospinal Fluid; Diagnosis, Differential; Endorphins; Enkephalins; Humans; Infant; Injections, Intravenous; Intellectual Disability; Male; Morphine; Naloxone; Necrosis; Spinal Cord Diseases; Syndrome | 1980 |
Endorphins in necrotizing encephalomyelopathy.
Topics: Brain Chemistry; Brain Diseases; Cerebrospinal Fluid; Endorphins; Enkephalins; Humans; Infant; Injections, Intravenous; Male; Naloxone; Necrosis; Spinal Cord Diseases | 1980 |
Stimulation of in vitro prolactin release by vasoactive intestinal peptide.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Gastrointestinal Hormones; Male; Naloxone; Prolactin; Rats; Vasoactive Intestinal Peptide | 1980 |
Modulation of synaptosomal GABA release by enkephalin.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naloxone; Potassium; Rats; Synaptosomes | 1980 |
Effects of the opiate antagonist naloxone and the enkephalin analog DAMME on the vasopressin response to a hypertonic stimulus in man.
Topics: Adult; Arginine Vasopressin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Humans; Kidney; Male; Naloxone; Osmolar Concentration; Saline Solution, Hypertonic; Sodium; Sodium Chloride | 1980 |
Enkephalin-induced growth hormone release in the dog.
Topics: Animals; Atropine; Brain; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalins; Female; Growth Hormone; Injections, Intravenous; Male; Naloxone; Stimulation, Chemical | 1980 |
Naloxone-reversible effects of d-Ala2-Met5-enkephalinamide-induced behavioral activity in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Male; Morphine; Motor Activity; Naloxone; Rats | 1980 |
Increased pressor responsiveness to enkephalin in spontaneously hypertensive rats: the role of vasopressin.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Endorphins; Enkephalins; Female; Heart Rate; Hypertension; Injections, Intraventricular; Male; Naloxone; Rats; Stimulation, Chemical | 1980 |
Differential effects of intracerebrally microinjected enkephalin analogs on centrally versus peripherally induced pain, and evidence for a facial versus lower body analgesic effect.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Endorphins; Enkephalins; Face; Injections, Intraventricular; Male; Microinjections; Naloxone; Nociceptors; Pain; Rats | 1980 |
Enkephalin involvement in acupuncture analgesia-radioimmunoassay.
Topics: Acupuncture Therapy; Analgesia; Animals; Bacitracin; Brain Chemistry; Endorphins; Enkephalins; Female; Hypothalamus; Male; Maximum Allowable Concentration; Naloxone; Rabbits; Radioimmunoassay; Rats | 1980 |
Action of enkephalin analogues and morphine on brain acetylcholine release: differential reversal by naloxone and an opiate pentapeptide.
Topics: Acetylcholine; Animals; Brain; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Morphine; Naloxone; Rats | 1980 |
In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice.
Topics: Amino Acid Sequence; Analgesia; Animals; Antibodies; Benzeneacetamides; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunization, Passive; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
[D-Pen2,D-Pen5]enkephalin, a delta opioid agonist reduces endogenous aluminum content in the rat central nervous system.
Topics: Aluminum; Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Time Factors | 1995 |
Regulation of L-valine absorption by opioids interacting with mu-receptors in rabbit ileum.
Topics: Analgesics; Animals; Body Water; Chlorides; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ileum; In Vitro Techniques; Intestinal Absorption; Kinetics; Male; Membrane Potentials; Morphine; Muscle, Smooth; Naloxone; Rabbits; Receptors, Opioid, mu; Sodium; Time Factors; Valine | 1995 |
Effects of morphine on forskolin-stimulated pro-enkephalin mRNA levels in rat striatum: a model for acute and chronic opioid actions in brain.
Topics: Analgesics; Animals; Colforsin; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Male; Models, Molecular; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1995 |
Effect of minute amounts of [D-Ala2,MePhe4,Gly(ol)5]enkephalin injected into the tuberomammillary nucleus of rats on histamine release from the cerebral cortex.
Topics: Animals; Cerebral Cortex; Enkephalins; Histamine Release; Male; Naloxone; Rats; Rats, Wistar; Time Factors | 1995 |
Implication of endogenous opioid system in the learned helplessness model of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Depression; Electroshock; Endorphins; Enkephalins; Helplessness, Learned; Hydroxamic Acids; Imipramine; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar | 1995 |
[The mechanism of the anti-arrhythmia action of opioid receptor agonists and antagonists].
Topics: Animals; Anti-Arrhythmia Agents; Calcium Chloride; Cardiac Complexes, Premature; Drug Evaluation, Preclinical; Enkephalins; Epinephrine; Ligands; Male; Naloxone; Rats; Rats, Wistar; Receptors, Opioid; Time Factors | 1993 |
Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons.
Topics: Amino Acid Sequence; Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; GTP-Binding Proteins; In Vitro Techniques; Molecular Sequence Data; Naloxone; Nerve Endings; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Reticular Formation; Substance P | 1993 |
3-Nitropropionic acid toxicity in the striatum.
Topics: Animals; Antihypertensive Agents; Base Sequence; Corpus Striatum; Dizocilpine Maleate; DNA; Dose-Response Relationship, Drug; Enkephalins; Gene Expression; Glial Fibrillary Acidic Protein; Histocytochemistry; In Situ Hybridization; Ligands; Male; Molecular Sequence Data; Naloxone; Neurons; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin; Substance P; Tritium | 1994 |
Opioids inhibit the induction of nitric oxide synthase in J774 macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Induction; Lipopolysaccharides; Macrophages; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Pyrrolidines; Receptors, Opioid | 1995 |
Brain dynorphin and enkephalin systems in Fischer and Lewis rats: effects of morphine tolerance and withdrawal.
Topics: Amino Acid Sequence; Animals; Body Weight; Brain Chemistry; Drug Tolerance; Dynorphins; Enkephalins; Female; Male; Molecular Sequence Data; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred F344; Rats, Inbred Lew; Species Specificity; Substance Withdrawal Syndrome | 1995 |
Opioid modulation of fetal glucose homeostasis: role of receptor subtypes.
Topics: Analgesics, Opioid; Animals; Blood Glucose; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Fetus; Glucose; Homeostasis; Lactates; Lactic Acid; Morphine; Naloxone; Narcotic Antagonists; Opioid Peptides; Pregnancy; Receptors, Opioid; Sheep | 1995 |
Characterization of the spinal antinociceptive activity of constrained peptidomimetic opioids.
Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Injections, Spinal; Male; Mice; Molecular Sequence Data; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Structure-Activity Relationship; Vas Deferens | 1995 |
The effects of morphine treatment and morphine withdrawal on the dynorphin and enkephalin systems in Sprague-Dawley rats.
Topics: Analysis of Variance; Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Male; Morphine; Naloxone; Peptides; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1995 |
Functional reconstitution of a highly purified mu-opioid receptor protein with purified G proteins in liposomes.
Topics: Animals; Brain; Cattle; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Liposomes; Naloxone; Narcotics; Receptors, Opioid, mu | 1995 |
Opioid peptide inhibition of endogenous norepinephrine release from the A2 noradrenergic cell group in vitro.
Topics: alpha-MSH; Animals; beta-Endorphin; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Medulla Oblongata; Melanocyte-Stimulating Hormones; Naloxone; Norepinephrine; Opioid Peptides; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1995 |
VV-hemorphin-7 and LVV-hemorphin-7 released during in vitro peptic hemoglobin hydrolysis are morphinomimetic peptides.
Topics: Animals; Binding, Competitive; Cattle; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Hemoglobins; Hydrolysis; Ileum; Male; Morphine; Naloxone; Pepsin A; Peptide Fragments; Rats; Rats, Wistar; Receptors, Opioid; Sensitivity and Specificity | 1995 |
Opioids modify the release of LH at the pituitary level: in vitro studies with entire rat pituitaries.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Naloxone; Narcotics; Oligopeptides; Organ Culture Techniques; Pituitary Gland; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Dalargin and [Cys-(O2NH2)]2 analogues of enkephalins and their selectivity for mu opioid receptors.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Naloxone; Receptors, Opioid, mu; Sympatholytics; Tetrodotoxin | 1995 |
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin | 1995 |
In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding.
Topics: Animals; Autoradiography; Baclofen; Benzoxazines; Brain; Cannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-B Receptor Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Morpholines; Naloxone; Naphthalenes; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu | 1995 |
[The role of G protein in Leu-enkephalin induced Ca2+ release from intracellular pool in myocytes].
Topics: Animals; Biological Transport, Active; Calcium; Enkephalin, Leucine; Female; GTP-Binding Proteins; Heart Ventricles; Male; Myocardium; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1995 |
Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine.
Topics: Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Ketorolac Tromethamine; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tolmetin; Tromethamine | 1995 |
Mitogenic activation of human T lymphocytes induces a high affinity morphine binding site.
Topics: Analgesics; beta-Endorphin; Cells, Cultured; Culture Media; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Interleukin-2; Ligands; Lymphocyte Activation; Mitogens; Morphine; Naloxone; Phytohemagglutinins; Receptors, Opioid; T-Lymphocytes | 1995 |
[Contribution of dopamine autoreceptors in the reactive effect of opioid antagonists].
Topics: Animals; Avoidance Learning; Dopamine Agonists; Enkephalin, Leucine; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Piperidines; Receptors, Dopamine; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella | 1993 |
Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Axonal Transport; beta-Endorphin; Biological Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Ligation; Male; Naloxone; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve | 1993 |
Leu-enkephalin modulates the migration inhibition of mouse splenocytes induced by cAMP-elevating agents.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Migration Inhibition; Cell Movement; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; In Vitro Techniques; Mice; Mice, Inbred CBA; Naloxone; Spleen; Theophylline | 1993 |
Activation of mu-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons.
Topics: Action Potentials; Amino Acid Sequence; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Sequence Data; Muscimol; Naloxone; Naltrexone; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Spinal Cord | 1994 |
Antinociceptive effect of intracerebroventricular injection of a tetrapeptide Asn-Ala-Gly-Ala in rats.
Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Intraventricular; Male; Naloxone; Oligopeptides; Pain Threshold; Rats; Rats, Sprague-Dawley | 1994 |
Dopaminergic and enkephalinergic involvement in the regulation of blood glucose in the red swamp crayfish, Procambarus clarkii.
Topics: Animals; Arthropod Proteins; Astacoidea; Blood Glucose; Dopamine; Dopamine Antagonists; Enkephalin, Leucine; Eye; Hemolymph; Invertebrate Hormones; Naloxone; Nerve Tissue Proteins; Neurosecretory Systems; Spiperone | 1995 |
Behavioral and neurochemical effects of opioids in the paramedian midbrain tegmentum including the median raphe nucleus and ventral tegmental area.
Topics: Animals; Brain Chemistry; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Male; Morphine; Motor Activity; Naloxone; Neurotransmitter Agents; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Tegmental Area | 1995 |
Estradiol-17 beta and mu-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback?
Topics: Animals; Arcuate Nucleus of Hypothalamus; Baclofen; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estradiol; Feedback; Female; Gonadotropin-Releasing Hormone; Guinea Pigs; Membrane Potentials; Naloxone; Neurons; Ovariectomy; Potassium Channels; Receptors, Opioid, mu; Tetrodotoxin | 1995 |
Antinociception produced by an ascending spino-supraspinal pathway.
Topics: Analgesics; Animals; Brain Stem; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Lidocaine; Male; Mice; Microinjections; Models, Neurological; Naloxone; Pain; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Synapses; Trigeminal Nerve | 1995 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Barium; Calcium Channels; Cell Line; Cloning, Molecular; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Transport; Membrane Potentials; Morphine; Naloxone; Pertussis Toxin; Pituitary Gland; Rats; Receptors, Opioid, mu; Somatostatin; Transfection; Virulence Factors, Bordetella | 1995 |
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu | 1995 |
Long-term exposure to opioid antagonists up-regulates prodynorphin gene expression in rat brain.
Topics: Animals; Brain; Enkephalins; Gene Expression; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Precursors; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
DAMGO, a mu-opioid receptor selective ligand, distinguishes between mu-and kappa-opioid receptors at a different region from that for the distinction between mu- and delta-opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Cells, Cultured; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ligands; Molecular Sequence Data; Morphine; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Somatostatin; Structure-Activity Relationship | 1995 |
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss | 1995 |
Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium | 1995 |
G-receptor antagonists increased the activating effect of mastoparan on low Km GTPase of mouse PAG.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Kinetics; Male; Mice; Naloxone; Peptides; Periaqueductal Gray; Receptors, Cell Surface; Somatostatin; Wasp Venoms | 1995 |
Radioligand-binding study of noribogaine, a likely metabolite of ibogaine.
Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; In Vitro Techniques; Kinetics; Naloxone; Pyrrolidines; Radioligand Assay; Receptors, Opioid | 1995 |
An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Injections, Intraventricular; Male; Mice; Models, Molecular; Molecular Sequence Data; Naloxone; Opioid Peptides; Pain Measurement; Protein Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism | 1994 |
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
Topics: Amino Acid Sequence; Animals; Brain Neoplasms; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured | 1994 |
Stimulatory effect of opioid peptides and naloxone on rat spinal cord cells in primary dissociated culture.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Molecular Sequence Data; Naloxone; Nerve Growth Factors; Rats; Rats, Wistar; Spinal Cord; Stimulation, Chemical | 1994 |
Opioid modulation of oxytocin release from spinal cord synaptosomes.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Naloxone; Nerve Endings; Oxytocin; Potassium Chloride; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord; Synaptosomes | 1994 |
Electrophysiological effects of selective opioid agonists on spontaneous and evoked neuronal activity in the dentate gyrus of the hippocampus in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Hippocampus; Interneurons; Male; Morphine; Naloxone; Neurons; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Opiate withdrawal intensity correlates with the presence of DSLET high-affinity binding.
Topics: Amino Acid Sequence; Analgesics; Animals; Drug Implants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Morphine; Morphine Dependence; Naloxone; Narcotics; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1994 |
Functional couplings of the delta- and the kappa-opioid receptors with the G-protein-activated K+ channel.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Base Sequence; Cloning, Molecular; Codon; DNA Primers; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kinetics; Membrane Potentials; Mice; Molecular Sequence Data; Naloxone; Oocytes; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Xenopus laevis | 1995 |
Antinociceptive effect of systemic PC 12, a prodrug mixed inhibitor of enkephalin-degrading enzymes, in normal and arthritic rats.
Topics: Aminopeptidases; Analgesics; Animals; Arthritis, Experimental; CD13 Antigens; Dose-Response Relationship, Drug; Enkephalins; Glycine; Male; Naloxone; Neprilysin; Pain; Pain Measurement; Prodrugs; Rats; Rats, Sprague-Dawley; Vocalization, Animal | 1993 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Augmenting effect of opioid peptides on murine macrophage activation.
Topics: Animals; beta-Endorphin; Cells, Cultured; Dynorphins; Endorphins; Enkephalins; Female; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Naloxone | 1994 |
Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Barium Compounds; Cadmium; Carbachol; Chlorides; Computer Simulation; Dynorphins; Electrophysiology; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Models, Neurological; Naloxone; Narcotics; Neurons; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Opioid actions on rat anterior cingulate cortex neurons in vitro.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glutamates; Glutamic Acid; Gyrus Cinguli; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Neurotransmitter Agents; Rats; Receptors, Opioid; Somatostatin; Synapses; Synaptic Transmission | 1994 |
Evidence for a central long-lasting antinociceptive effect of vapreotide, an analog of somatostatin, involving an opioidergic mechanism.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Disease Models, Animal; Edema; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Inflammation; Male; Membranes; Mice; Molecular Sequence Data; Morphine; Motor Activity; Naloxone; Necrosis; Nociceptors; Octreotide; Pain Measurement; Rats; Rats, Sprague-Dawley; Somatostatin; Spinal Cord; Time Factors; Tritium | 1994 |
The mechanism involved in the central effect of 5-leu enkephalin on the calcitonin secretion.
Topics: Animals; Calcitonin; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Naloxone; Narcotic Antagonists; Oxidopamine; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Sympathectomy, Chemical; Thyroid Gland | 1993 |
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation.
Topics: Abdominal Muscles; Aminopeptidases; Analgesics; Animals; CD13 Antigens; Disulfides; Enkephalins; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Phenylalanine | 1994 |
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
Topics: Analysis of Variance; Animals; Antibodies; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclosporine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Inflammation; Injections; Interleukin-1; Male; Naloxone; Pain; Rats; Rats, Wistar; Recombinant Proteins; Regression Analysis; Somatostatin | 1994 |
Facilitation of self-stimulation of ventral tegmentum by microinjection of opioid receptor subtype agonists.
Topics: Analgesics; Animals; Brain Mapping; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Hypothalamic Area, Lateral; Male; Medial Forebrain Bundle; Motivation; Naloxone; Neural Pathways; Rats; Rats, Wistar; Receptors, Opioid; Self Stimulation; Substantia Nigra; Tegmentum Mesencephali; Ventral Tegmental Area | 1994 |
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
Topics: Animals; Benzimidazoles; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, mu; Spinal Cord | 1994 |
[3H]dynorphin1-8 binding sites in frog (Rana esculenta) brain membranes.
Topics: Amino Acid Sequence; Animals; Brain; Cell Membrane; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Naloxone; Peptide Fragments; Rana esculenta; Receptors, Opioid; Sodium Chloride; Tritium | 1994 |
Dissimilar efficacy of opioids to produce mu-mediated analgesia: role of Gx/z and Gi2 transducer proteins.
Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Cell Membrane; Cerebral Ventricles; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Immunoglobulin G; Injections, Intraventricular; Kinetics; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Pain; Peptide Fragments; Receptors, Opioid, mu; Signal Transduction | 1994 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
The influence of captopril and naloxone on the Valsalva manoeuvre and systolic time intervals in healthy volunteers.
Topics: Adult; Blood Pressure; Captopril; Enkephalins; Heart Rate; Humans; Male; Myocardial Contraction; Naloxone; Reference Values; Systole; Valsalva Maneuver | 1994 |
Bimodal opioid regulation of cyclic AMP formation: implications for positive and negative coupling of opiate receptors to adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enkephalins; Humans; Muscles; Myenteric Plexus; Naloxone; Narcotics; Radioimmunoassay; Receptors, Opioid; Sufentanil | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Effects of mu-, delta- and kappa-agonists on isolated right atria of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Propranolol; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Hepatic uptake and intracellular processing of opioid pentapeptides.
Topics: Animals; Enkephalin, Leucine; Humans; Liver; Male; Naloxone; Rats; Rats, Wistar | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1994 |
Beta-funaltrexamine blockade of opioid-induced inhibition of somatostatin secretion from rat stomach.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Radioimmunoassay; Rats; Rats, Wistar; Somatostatin | 1994 |
Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids.
Topics: Animals; beta-Galactosidase; Enkephalins; Gene Expression Regulation; Hypothalamus; Male; Mice; Mice, Transgenic; Naloxone; Narcotic Antagonists; Narcotics; Paraventricular Hypothalamic Nucleus; Protein Precursors; Proto-Oncogene Proteins c-fos; Stress, Physiological; Supraoptic Nucleus | 1994 |
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1994 |
Characterization of opioid binding sites in the neural and intermediate lobe of the rat pituitary gland by quantitative receptor autoradiography.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Densitometry; Enkephalins; Ligands; Male; Molecular Sequence Data; Naloxone; Naltrexone; Pituitary Gland; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, kappa | 1994 |
TRIMU-5, a mu 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis.
Topics: Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Kinetics; Male; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1994 |
Effects of mu and delta opioid receptor agonists and antagonists on absence epilepsy in WAG/Rij rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epilepsy, Absence; Male; Naloxone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity.
Topics: Amino Acids; Animals; Cell Membrane; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Morphine; Mutagenesis, Site-Directed; Naloxone; Rats; Receptors, Opioid, mu; Sequence Deletion; Structure-Activity Relationship | 1994 |
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 1994 |
Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH.
Topics: Cell Line; Dextrorphan; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Levorphanol; Morphine; Naloxone; Narcotics; Neuroblastoma; Norepinephrine; Receptors, Opioid; Tritium; Tumor Cells, Cultured | 1994 |
Comparison of cardiovascular effects of mu- and delta-opioid receptor antagonists in dogs with congestive heart failure.
Topics: Animals; Blood Circulation; Cardiovascular System; Dogs; Enkephalin, Leucine; Heart Failure; Hemodynamics; Naloxone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu; Regional Blood Flow; Ventricular Function, Right | 1994 |
Age-related changes in biogenic amines, opiate, and steroid receptors in the prepubertal bull calf.
Topics: Aging; alpha-Methyltyrosine; Analysis of Variance; Animals; Biogenic Amines; Cattle; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamus; Luteinizing Hormone; Male; Methyltyrosines; Naloxone; Pituitary Gland; Radioimmunoassay; Receptors, Opioid; Receptors, Steroid; Tyrosine 3-Monooxygenase | 1993 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Endogenous opioid regulation of oxytocin secretion through pregnancy in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Pregnancy; Pregnancy, Animal; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Vasopressins | 1993 |
Opioid actions on neurons of rat lateral amygdala in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Amino Acids; Amygdala; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; GABA-A Receptor Antagonists; In Vitro Techniques; Molecular Sequence Data; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pyrrolidines; Rats; Somatostatin; Synapses | 1993 |
Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum: role of opiates and 5-hydroxytryptamine.
Topics: Analgesics; Animals; Atropine; Autonomic Nervous System; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Rats; Rats, Wistar; Serotonin; Synaptic Transmission; Tetrodotoxin | 1993 |
Responses of rat nucleus submedius neurons to enkephalins applied with micropressure.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Membrane Potentials; Micromanipulation; Naloxone; Neurons; Pain; Pressure; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Thalamic Nuclei | 1993 |
Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine.
Topics: Analgesics; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Enkephalin-containing peptides processed from proenkephalin significantly enhance the antibody-forming cell responses to antigens.
Topics: Amino Acid Sequence; Animals; Antibody Formation; Antibody-Producing Cells; B-Lymphocytes; Cattle; Dose-Response Relationship, Immunologic; Enkephalins; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Naloxone; Peptide Fragments; Protein Precursors; Protein Processing, Post-Translational; T-Lymphocytes | 1994 |
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Fura-2; Glioma; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Microscopy, Fluorescence; Naloxone; Narcotics; Neuroblastoma; Pyrrolidines; Rats; Tumor Cells, Cultured | 1994 |
Tyrosine phosphorylation of a 58 kDa protein induced by morphine in SK-N-SH cells.
Topics: Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Kinetics; Molecular Weight; Morphine; Naloxone; Nerve Tissue Proteins; Pertussis Toxin; Phosphorylation; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Tyrosine; Virulence Factors, Bordetella | 1994 |
Mouse brain opioid receptor identification by direct ultraviolet photoaffinity labeling.
Topics: Affinity Labels; Animals; Binding Sites; Dithiothreitol; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Naloxone; Receptors, Opioid; Tritium; Tyrosine; Ultraviolet Rays | 1993 |
Multiple opioid system involvement in the mediation of parasitic-infection induced analgesia.
Topics: Analgesia; Animals; Coccidiosis; Endorphins; Enkephalin, Leucine; Host-Parasite Interactions; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists | 1993 |
Opioid antagonist diprenorphine microinjected into parabrachial nucleus selectively inhibits vasopressin response to hypovolemic stimuli in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Disease; Animals; Antihypertensive Agents; Brain; Cerebral Ventricles; Diprenorphine; Enkephalin, Leucine; Hemodynamics; Male; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Shock; Solitary Nucleus; Stimulation, Chemical; Vasopressins | 1993 |
Mu- and delta-opioid receptors inhibitorily linked to dopamine-sensitive adenylate cyclase in rat striatum display a selectivity profile toward endogenous opioid peptides different from that of presynaptic mu, delta and kappa receptors.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Corpus Striatum; Dopamine; Endorphins; Enkephalins; Fentanyl; In Vitro Techniques; Isothiocyanates; Male; Naloxone; Norepinephrine; Protease Inhibitors; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, Presynaptic; Sulpiride | 1993 |
Increased in vivo release of calcitonin gene-related peptide-like material from the spinal cord in arthritic rats.
Topics: Analgesics; Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Injections, Spinal; Iodine Radioisotopes; Male; Naloxone; Perfusion; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord | 1993 |
The modulatory effects of mu and kappa opioid agonists on 5-HT release from hippocampal and hypothalamic slices of euthermic and hibernating ground squirrels.
Topics: Amino Acid Sequence; Analgesics; Animals; Body Temperature; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hibernation; Hippocampus; Hypothalamus; Male; Molecular Sequence Data; Naloxone; Narcotics; Potassium; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciuridae; Serotonin; Stimulation, Chemical; Tetrodotoxin | 1993 |
Inhibitory effects of NaCl and guanyl-5'yl-imidodiphosphate (GppNHp) on [3H]naloxone binding to kappa-opioid receptors in guinea pig cerebellum.
Topics: Animals; Benzeneacetamides; Binding Sites; Cerebellum; Cerebral Cortex; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Guanylyl Imidodiphosphate; Guinea Pigs; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sodium Chloride | 1993 |
Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons.
Topics: Analgesics; Animals; Baclofen; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Homeostasis; In Vitro Techniques; Male; Naloxone; Nerve Fibers; Neurons; Phosphinic Acids; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Opioid, mu; Synapses | 1993 |
[The effect of synthetic enkephalin analogs on the development of traumatic brain edema].
Topics: Animals; Brain Edema; Brain Injuries; Dose-Response Relationship, Drug; Enkephalins; Female; Male; Naloxone; Rats; Receptors, Opioid; Time Factors | 1993 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
Evidence for a multi-compartmental histochemical organization of the nucleus accumbens in the rat.
Topics: Animals; Autoradiography; Basal Ganglia; Caudate Nucleus; Enkephalins; Immunohistochemistry; Naloxone; Nucleus Accumbens; Putamen; Rats; Receptors, Opioid | 1993 |
Mu-opiate receptor binding and function in HOT and COLD selected lines of mice.
Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Body Temperature; Brain; Brain Chemistry; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethanol; Female; Levorphanol; Male; Mice; Mice, Inbred Strains; Naloxone; Nerve Tissue Proteins; Receptors, Opioid, mu | 1993 |
Characterization and localization of delta opioid binding sites in the bovine pineal gland.
Topics: Animals; Autoradiography; Binding Sites; Cattle; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Naloxone; Pineal Gland; Receptors, Opioid, delta | 1993 |
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Restraint, Physical; Stomach Ulcer; Stress, Physiological | 1993 |
[Role of nucleus accumbens in cardiovascular activities and its relationship with opioid peptides in rats].
Topics: Animals; Blood Pressure; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heart Rate; Kainic Acid; Locus Coeruleus; Microinjections; Naloxone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
On the role of enkephalin cotransmission in the GABAergic striatal efferents to the globus pallidus.
Topics: Animals; Bicuculline; Corpus Striatum; Drug Combinations; Efferent Pathways; Enkephalins; gamma-Aminobutyric Acid; Globus Pallidus; Male; Motor Activity; Naloxone; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Reserpine; Synaptic Transmission | 1994 |
Sex differences in the antinociceptive effects of the enkephalinase inhibitor, SCH 34826.
Topics: Analgesia; Analgesics; Animals; Dioxolanes; Dipeptides; Enkephalin, Leucine; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Peromyscus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Sex Characteristics; Stress, Psychological | 1993 |
Sodium ions modulate differentially the effect of a benzodiazepine agonist on rat spinal mu-, delta- and kappa-opioid receptors.
Topics: Animals; Enkephalins; Ligands; Male; Midazolam; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium; Spinal Cord | 1994 |
Use-dependent fade and two-rate recovery of a naloxone-sensitive inhibition in the cat superior cervical ganglion.
Topics: Action Potentials; Animals; Cats; Colchicine; Conditioning, Psychological; Drug Interactions; Electric Stimulation; Enkephalin, Leucine; Female; Ganglia, Sympathetic; Male; Naloxone; Time Factors | 1993 |
Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Glioma; GTP-Binding Proteins; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Naloxone; Neuroblastoma; Pertussis Toxin; Receptors, Bradykinin; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Purinergic; Terpenes; Thapsigargin; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
Enkephalin suppresses afferent cochlear neurotransmission.
Topics: Animals; Cochlea; Dendrites; Enkephalins; Guinea Pigs; Hair Cells, Auditory, Inner; Kainic Acid; N-Methylaspartate; Naloxone; Neurons, Afferent; Neurons, Efferent; Quisqualic Acid; Synaptic Transmission | 1993 |
Involvement of delta 2 opioid receptors in the development of morphine dependence in mice.
Topics: Animals; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Thiocyanates | 1993 |
Schistosoma mansoni: an enkephalinergic system that may participate in internal and host-parasite signaling.
Topics: Animals; beta-Endorphin; Binding, Competitive; Biomphalaria; Cell Communication; Cricetinae; Enkephalin, Methionine; Enkephalins; Host-Parasite Interactions; Naloxone; Radioimmunoassay; Receptors, Opioid; Schistosoma mansoni; Signal Transduction; Trypsin; Trypsin Inhibitors | 1993 |
Possible involvement of mu 2-mediated mechanisms in mu-mediated antitussive activity in the mouse.
Topics: Analgesics; Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Reaction Time; Receptors, Opioid, mu | 1993 |
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1993 |
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
Highly potent novel opioid receptor agonist in the 14-alkoxymetopon series.
Topics: Analgesics; Animals; Behavior, Animal; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Male; Mice; Morphine Derivatives; Naloxone; Oxymorphone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Species Specificity; Substance-Related Disorders | 1993 |
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal | 1993 |
Autoradiographic localization of opioid binding sites combined with immunogold detection of Leu-enkephalin, crustacean hyperglycaemic hormone and moult inhibiting hormone at the electron microscopic level in the sinus gland of the shore crab, Carcinus mae
Topics: Animals; Arthropod Proteins; Autoradiography; Axons; Brachyura; Cytoplasmic Granules; Enkephalin, Leucine; Exocrine Glands; Immunohistochemistry; Invertebrate Hormones; Microscopy, Electron; Naloxone; Nerve Endings; Nerve Tissue Proteins; Receptors, Opioid | 1993 |
Reconstitution of a purified mu-opioid binding protein in liposomes: selective, high affinity, GTP gamma S-sensitive mu-opioid agonist binding is restored.
Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Cholic Acids; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Liposomes; Morphine; Naloxone; Narcotics; Receptors, Opioid, mu | 1993 |
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal | 1993 |
DAMGO stimulates the hypothalamo-pituitary-adrenal axis through a mu-2 opioid receptor.
Topics: Analgesics; Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
Role of mu 1- and delta-opioid receptors in modulation of fetal EEG and respiratory activity.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetal Movement; Fetus; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep | 1993 |
Evidence for an involvement of the mu-type of opioid receptor in the modulation of learning.
Topics: Animals; Autoradiography; Blinking; Brain; Cerebral Ventricles; Conditioning, Classical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intraventricular; Learning; Male; Naloxone; Nictitating Membrane; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1993 |
Modulation of the enkephalinergic phenotype of rat sympathetic neurons by hormonal and transsynaptic mechanisms.
Topics: Adrenalectomy; Animals; Autonomic Fibers, Preganglionic; Denervation; Dexamethasone; Enkephalin, Leucine; Female; Glucocorticoids; Immunohistochemistry; Naloxone; Neurons; Neuropeptides; Phenotype; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Sympathetic Nervous System; Synapses | 1993 |
Stimulation of opioid receptors on cardiac ventricular myocytes reduces L type Ca2+ channel current.
Topics: Animals; Calcium Channels; Enkephalin, Leucine; Male; Membrane Potentials; Myocardium; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid | 1993 |
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders | 1993 |
In vivo modulation of gastrointestinal motor activity by Met-enkephalin, morphine and enkephalin analogs in chickens.
Topics: Amino Acid Sequence; Animals; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Immunohistochemistry; Male; Molecular Sequence Data; Morphine; Motor Activity; Naloxone; Nerve Fibers; Vagotomy; Vagus Nerve | 1993 |
Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics; Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Morphine; Naloxone; Pertussis Toxin; Phosphodiesterase Inhibitors; Rats; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1995 |
Effect of Met-enkephalin and opioid antagonists on rat macrophages.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hydrogen Peroxide; Infant, Newborn; Macrophages; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1995 |
Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Peripheral Nerve Injuries; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1995 |
Electrochemical evidence of increased dopamine transmission in prefrontal cortex and nucleus accumbens elicited by ventral tegmental mu-opioid receptor activation in freely behaving rats.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine; Electrochemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Microinjections; Naloxone; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Inbred Strains; Receptors, Opioid, mu; Stereotyped Behavior; Synaptic Transmission; Tegmentum Mesencephali | 1995 |
Plasma levels of beta-endorphin, leucine enkephalin and arginine vasopressin in patients with essential hypertension and the effects of clonidine.
Topics: Angiotensin II; Antihypertensive Agents; Arginine Vasopressin; beta-Endorphin; Blood Pressure; Clonidine; Enkephalin, Leucine; Female; Heart Rate; Humans; Hypertension; Injections, Intravenous; Male; Middle Aged; Naloxone; Narcotic Antagonists; Neurotensin; Renin; Time Factors | 1995 |
Memory retrieval enhancement by kappa opioid agonist and mu, delta antagonists.
Topics: Analysis of Variance; Animals; Dynorphins; Enkephalin, Leucine; Male; Memory; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Opioid peptides in the nervous system of Aplysia: a combined biochemical, immunocytochemical, and electrophysiological study.
Topics: Analgesics, Opioid; Animals; Aplysia; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ganglia, Invertebrate; Immunohistochemistry; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Organ Specificity; Patch-Clamp Techniques; Receptors, Opioid | 1995 |
Differential blockade of morphine and morphine-6 beta-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Base Sequence; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Male; Microinjections; Molecular Sequence Data; Morphine; Morphine Derivatives; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1995 |
Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal.
Topics: Adenosine; Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Rats; Rats, Sprague-Dawley; Xanthines | 1995 |
Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors.
Topics: Amino Acid Sequence; Analgesics; Base Sequence; Benzomorphans; Binding, Competitive; Cell Line; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Kidney; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Substrate Specificity; Transfection | 1995 |
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
ATP serves as a negative feedback inhibitor of voltage-gated Ca2+ channel currents in cultured bovine adrenal chromaffin cells.
Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ion Channel Gating; Membrane Potentials; Naloxone; Triazines | 1996 |
Dexamethasone selective inhibition of acute opioid physical dependence in isolated tissues.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mifepristone; Muscle Contraction; Naloxone; Opioid-Related Disorders; Pyrrolidines; Rabbits; Substance Withdrawal Syndrome | 1996 |
Electrophysiological effects of Mu-selective opioids on hilar neurons in the hippocampus in vivo.
Topics: Action Potentials; Analgesics, Opioid; Animals; Dentate Gyrus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naloxone; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1995 |
The effects of delta-opioid receptor agonists on synaptic transmission in hamster submandibular ganglion.
Topics: Animals; Autonomic Fibers, Preganglionic; Cricetinae; Dimethylphenylpiperazinium Iodide; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; Ganglionic Stimulants; Naloxone; Narcotic Antagonists; Presynaptic Terminals; Receptors, Opioid, delta; Submandibular Gland; Synaptic Transmission | 1995 |
[Change in activity of enkephalinase from various structures of the rat brain during administration of naloxone and in morphine tolerance].
Topics: Aminopeptidases; Analgesics, Opioid; Animals; Brain; Drug Resistance; Enkephalins; Male; Morphine; Naloxone; Rats; Rats, Wistar | 1995 |
Leu-enkephalin enhances interferon secretion in mice.
Topics: Animals; Enkephalin, Leucine; Interferon Inducers; Interferons; Killer Cells, Natural; Male; Mice; Mice, Inbred CBA; Naloxone; Narcotic Antagonists; Poly I-C; Spleen | 1996 |
L-Arginine reverses the abolition of hypovolaemic decompensation by N-nitro-L-arginine methyl ester and naloxone in conscious rabbits.
Topics: Animals; Arginine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Shock, Hemorrhagic | 1995 |
Ocular action of an opioid peptide, DPDPE.
Topics: Administration, Topical; Analgesics; Animals; Ciliary Body; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Intraocular Pressure; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits | 1996 |
The mu-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a nonopioid receptor-mediated increase in K+ conductance of rat locus ceruleus neurons.
Topics: Animals; Brimonidine Tartrate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Locus Coeruleus; Male; Naloxone; Narcotics; Neurons; Nociceptin; Opioid Peptides; Peptide Fragments; Peptides; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 1996 |
Circannual variations in bear plasma albumin and its opioid-like effects on guinea pig ileum.
Topics: Analgesics; Animals; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hibernation; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Seasons; Serum Albumin; Ursidae | 1996 |
Alcohol drinking is reduced by a mu 1- but not by a delta-opioid receptor antagonist in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
The analgesic drug buprenorphine inhibits osteoclastic bone resorption in vitro, but is proinflammatory in rat adjuvant arthritis.
Topics: Analgesics; Analgesics, Opioid; Animals; Arthritis, Experimental; Arthrography; Bone Resorption; Buprenorphine; Cells, Cultured; Disease Models, Animal; Edema; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Femur; Lethal Dose 50; Naloxone; Narcotic Antagonists; Osteoclasts; Rats | 1996 |
Lack of effect of gamma-hydroxybutyrate on mu, delta and kappa opioid receptor binding.
Topics: Adjuvants, Anesthesia; Analgesics; Animals; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Glioma; Guinea Pigs; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Oxybate; Tritium; Tumor Cells, Cultured | 1996 |
Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aminobutyrates; Analgesics; Animals; Brain; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Thalamus | 1996 |
Inhibition of noxious stimulus-evoked pain behaviors and neuronal fos-like immunoreactivity in the spinal cord of the rat by supraspinal morphine.
Topics: Analgesics; Analgesics, Opioid; Animals; Area Under Curve; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunohistochemistry; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 1996 |
Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat.
Topics: Animals; Blood Pressure; Cardiovascular System; Enkephalin, Leucine; Heart Rate; Male; Microinjections; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Solitary Nucleus; Vagus Nerve | 1996 |
Effects of prenatal morphine and adult estrogen administration on mu-opioid inhibition of norepinephrine release from hypothalamic slices.
Topics: Amino Acid Sequence; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estradiol; Female; Hypothalamus; Male; Molecular Sequence Data; Morphine; Naloxone; Norepinephrine; Ovariectomy; Potassium Chloride; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1996 |
Systemic morphine and local opioid effects on neuronal activity in the medial prefrontal cortex.
Topics: Acetylcholine; Animals; Electrophoresis; Enkephalins; Male; Morphine; Naloxone; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
Portacaval anastomosis induces region-selective alterations of the endogenous opioid system in the rat brain.
Topics: Alcohol Drinking; Analysis of Variance; Animals; beta-Endorphin; Brain; Brain Chemistry; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Narcotic Antagonists; Pituitary Gland; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
Reductions in locomotor activity following central opioid receptor subtype antagonists in rats.
Topics: Animals; Enkephalins; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley | 1996 |
Endogenous opioid-mediated inhibition of putative pain-modulating neurons in rat rostral ventromedial medulla.
Topics: Animals; Bicuculline; Brain Mapping; Enkephalins; Evoked Potentials; Male; Medulla Oblongata; Morphine; Naloxone; Nerve Endings; Neurons; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reflex | 1996 |
Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of trigeminothalamic neurons.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microelectrodes; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Trigeminal Nuclei | 1996 |
Increase of preproenkephalin mRNA in the caudal part of periaqueductal gray by morphine withdrawal in rats: a quantitative in situ hybridization study.
Topics: Animals; Enkephalins; In Situ Hybridization; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome | 1996 |
Cardiovascular effects of intrathecally injected mu, delta and kappa opioid receptor agonists in rabbits.
Topics: Animals; Baroreflex; Benzomorphans; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Naloxone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
Role of kappa opioid receptors in modulating cholinergic twitches in the circular muscle of guinea-pig colon.
Topics: Acetylcholine; Animals; Colon; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Cholinergic; Receptors, Opioid, kappa | 1996 |
Biphalin, an enkephalin analog with unexpectedly high antinociceptive potency and low dependence liability in vivo, selectively antagonizes excitatory opioid receptor functions of sensory neurons in culture.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Cells, Cultured; Culture Techniques; Drug Tolerance; Electrophysiology; Enkephalins; Ganglia, Spinal; Mice; Molecular Sequence Data; Morphine; Naloxone; Narcotic Antagonists; Neurons, Afferent | 1995 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design.
Topics: Analgesia; Analgesics; Blood-Brain Barrier; Brain; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Delivery Systems; Drug Design; Enkephalin, Leucine; Esterases; Lipase; Naloxone; Nicotine; Peptides; Prodrugs; Receptors, Opioid | 1996 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Haloperidol; Humans; Kinetics; Morphine; Naloxone; Neuroblastoma; Pentazocine; Phosphatidylinositols; Receptors, Opioid; Receptors, sigma; Trypsin; Tumor Cells, Cultured | 1996 |
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons; Nociceptors; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus | 1996 |
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Dinoprostone; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Models, Biological; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Receptors, Purinergic P1; Second Messenger Systems; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthines; Yohimbine | 1997 |
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration | 1997 |
Pharmacological characterization of buprenorphine, a mixed agonist-antagonist with kappa 3 analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Buprenorphine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sensitivity and Specificity | 1997 |
Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: decrease in activity after chronic morphine treatment.
Topics: Analgesics; Analgesics, Opioid; Animals; beta-Endorphin; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Locus Coeruleus; Male; Membrane Proteins; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sulfur Radioisotopes | 1997 |
Neurotransmitter background of the anti-inflammatory effect evoked by activation of sensory nerve fibers.
Topics: Animals; Edema; Enkephalins; Evoked Potentials; Inflammation; Mustard Plant; Naloxone; Nerve Fibers; Neurons, Afferent; Neuropeptides; Neurotransmitter Agents; Paraffin; Plant Extracts; Plant Oils; Plants, Medicinal; Rats; Skin | 1996 |
Ultralow concentrations of proenkephalin and [met5]-enkephalin differentially affect IgM and IgG production by B cells.
Topics: Animals; B-Lymphocytes; Cell Division; Dextran Sulfate; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Female; Immunoglobulin G; Immunoglobulin M; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Osmolar Concentration; Protein Precursors | 1997 |
Delta and kappa opioid receptor subtypes and ingestion: antagonist and glucoprivic effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Ventricles; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperphagia; Infusions, Parenteral; Male; Naloxone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regression Analysis | 1997 |
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors | 1997 |
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analgesics; Animals; beta-Endorphin; Clonidine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Interleukin-6; Isoproterenol; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Narcotic Antagonists; Neurons; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid; Spleen | 1997 |
Regulation of opioid receptors in rat sensory neurons in culture.
Topics: Analgesics; Animals; Cells, Cultured; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Kinetics; Naloxone; Narcotic Antagonists; Neurons, Afferent; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium; Up-Regulation | 1997 |
Modulation of neurotransmitter release by opioid mu- and kappa-receptors from adrenergic terminals in the myenteric plexus of the guinea-pig colon: effect of alpha 2-autoreceptor blockade.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yohimbine | 1997 |
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Mice; Mice, Inbred C57BL; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neostigmine; Oligopeptides; Peptide Fragments | 1997 |
Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cyclic AMP; Cytosol; Electric Conductivity; Enkephalin, Leucine; Heart Ventricles; Myocardial Contraction; Myocardium; Naloxone; Narcotic Antagonists; Norepinephrine; Pertussis Toxin; Rats; Receptors, Adrenergic, beta; Receptors, Opioid, delta; Sarcolemma; Thionucleotides; Virulence Factors, Bordetella | 1997 |
Dissociation of tolerance and dependence for opioid peripheral antinociception in rats.
Topics: Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Oxytocics; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Second Messenger Systems; Substance-Related Disorders | 1997 |
'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart.
Topics: Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Animals; Blood Pressure; Colforsin; Cyclic AMP; Enkephalin, Leucine; Ethanolamines; GTP-Binding Proteins; Heart; Male; Myocardium; Naloxone; Narcotic Antagonists; Norepinephrine; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Opioid, delta; Sarcolemma; Second Messenger Systems; Systole; Thionucleotides; Ventricular Function, Left; Virulence Factors, Bordetella | 1997 |
Role of midbrain ventro-lateral tegmental area (VTA) enkephalinergic mechanisms in the facilitation of hypothalamically-induced predatory attack behaviour.
Topics: Animals; Cats; Drug Interactions; Electric Stimulation; Electrodes, Implanted; Enkephalin, Methionine; Enkephalins; Female; Hypothalamus; Male; Microinjections; Naloxone; Narcotic Antagonists; Predatory Behavior; Rats; Staining and Labeling; Ventral Tegmental Area | 1997 |
[The effect of naloxone and leu-enkephalin on the atretic changes in the ovarian follicles of hypophysectomized rats].
Topics: Analysis of Variance; Animals; Diethylstilbestrol; Enkephalin, Leucine; Estrogens, Non-Steroidal; Female; Follicular Atresia; Hypophysectomy; Naloxone; Narcotic Antagonists; Pituitary Gland; Rats; Rats, Wistar; Receptors, Opioid; Time Factors | 1996 |
Central regulation of urine production by a selective mu-opioid agonist, [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin, in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Blood Pressure; Diuresis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heart Rate; Male; Microinjections; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Phenoxybenzamine; Rats; Rats, Wistar; Receptors, Opioid, mu; Supraoptic Nucleus; Timolol; Urine | 1997 |
Intracisternal injection of opioids induces itch-associated response through mu-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cisterna Magna; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Pruritus; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Pulsed magnetic field induced "analgesia" in the land snail, Cepaea nemoralis, and the effects of mu, delta, and kappa opioid receptor agonists/antagonists.
Topics: Analgesia; Animals; Electromagnetic Fields; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Snails | 1997 |
Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Vas Deferens | 1997 |
Enzymatic inactivation of enkephalin neurotransmitters in the spinal cord of the neonatal rat.
Topics: Animals; Animals, Newborn; Electric Stimulation; Electrophysiology; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Membrane Potentials; Naloxone; Narcotic Antagonists; Neprilysin; Neurotransmitter Agents; Protease Inhibitors; Rats; Spinal Cord; Spinal Nerve Roots; Synaptic Membranes | 1997 |
The stimulatory effect of opioids on cyclic AMP production in SK-N-SH cells is mediated by calcium ions.
Topics: Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Cyclic AMP; Egtazic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Naloxone; Narcotic Antagonists; Neuroblastoma; Opioid Peptides; Sulfonamides | 1997 |
Stimulatory effect of intracerebroventricular met- and leu-enkephalin on corticosterone secretion in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Ventricles; Corticosterone; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Adrenergic; Yohimbine | 1996 |
Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalins; Iodine Radioisotopes; Kinetics; Models, Chemical; Naloxone; Naltrexone; Narcotic Antagonists; Organ Specificity; Peptides; Radioisotope Dilution Technique; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tissue Distribution | 1997 |
[The anti-arrhythmic effect of the mu-opiate receptor agonists in adrenal arrhythmia: the role of the autonomic nervous system].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Autonomic Nervous System; Electrocardiography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Ganglionic Blockers; Hexamethonium; Male; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu | 1996 |
Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail.
Topics: Alanine; Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Point Mutation; Rats; Receptors, Opioid, mu; Recombinant Proteins; Serine; Threonine; Transfection | 1997 |
Reduction of NMDA-induced Ca2+ transients by a mu-opioid receptor agonist in dorsal horn neurons.
Topics: Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Naloxone; Narcotic Antagonists; Neurons; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 1997 |
Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area.
Topics: Afferent Pathways; Analgesics, Opioid; Animals; Behavior, Animal; Benzazepines; Bicuculline; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Injections; Injections, Intraperitoneal; Interneurons; Morphine; Motor Activity; Naloxone; Nerve Tissue Proteins; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Substantia Nigra; Tegmentum Mesencephali | 1997 |
Regulation of spontaneous activity of the delta-opioid receptor: studies of inverse agonism in intact cells.
Topics: Adenine; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cholera Toxin; Clone Cells; Colforsin; Cyclic AMP; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Mice; Naloxone; Narcotic Antagonists; Pertussis Toxin; Rats; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1997 |
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum.
Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling.
Topics: Adenylyl Cyclases; Analgesics; Animals; Binding, Competitive; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Ligands; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid, mu | 1997 |
Opioid effects on mitogen-activated protein kinase signaling cascades.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Mitogen-Activated Protein Kinase 1; Naloxone; Narcotics; Signal Transduction | 1997 |
The effects of postmortem delay on mu, delta and kappa opioid receptor subtypes in rat brain and guinea pig cerebellum evaluated by radioligand receptor binding.
Topics: Animals; Benzeneacetamides; Brain; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Kinetics; Male; Naloxone; Postmortem Changes; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1997 |
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon | 1997 |
Differential effects of beta-endorphin and Met- and Leu-enkephalin on steroid hormone-induced lordosis in ovariectomized female rats.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Female; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Ovariectomy; Posture; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Steroids | 1997 |
Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.
Topics: Alkaloids; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Histidine; Mutation; Naloxone; Narcotic Antagonists; Narcotics; Opioid Peptides; Rats; Receptors, Opioid, mu; Tritium; Xenopus laevis | 1997 |
Opioid-induced release of neurotensin in the periaqueductal gray matter of freely moving rats.
Topics: Analgesics, Opioid; Animals; Bicuculline; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA Agonists; GABA Antagonists; Male; Morphine; Muscimol; Naloxone; Narcotic Antagonists; Narcotics; Neurotensin; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 1997 |
Actions of opioids on respiratory activity via activation of brainstem mu-, delta- and kappa-receptors; an in vitro study.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Medulla Oblongata; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiratory System | 1997 |
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bicuculline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GABA Antagonists; Hot Temperature; Iontophoresis; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Peptide Fragments; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1998 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Animals; Antibody Specificity; Astrocytes; Brain Chemistry; Calcium; Cell Cycle; Cell Division; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Flow Cytometry; Hippocampus; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Fine-tuning control of testicular functions.
Topics: Animals; beta-Endorphin; Corticotropin-Releasing Hormone; Enkephalins; Immune Sera; Injections; Male; Naloxone; Narcotic Antagonists; Oxidopamine; Oxytocin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Somatostatin; Sympathectomy; Testis; Vasectomy | 1997 |
Endomorphin-stimulated [35S]GTPgammaS binding in rat brain: evidence for partial agonist activity at mu-opioid receptors.
Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sulfur Radioisotopes | 1998 |
In vivo assessment of opioid agonists and antagonists on ovarian maturation in the red swamp crayfish, Procambarus clarkii.
Topics: Animals; Astacoidea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Naloxone; Narcotic Antagonists; Ovary; Receptors, Opioid, delta | 1996 |
Opioids disrupt Ca2+ homeostasis and induce carbonyl oxyradical production in mouse astrocytes in vitro: transient increases and adaptation to sustained exposure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Astrocytes; Calcium; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homeostasis; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Narcotics; Oxidative Stress; Reactive Oxygen Species; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Time course of morphine withdrawal and preproenkephalin gene expression in the periaqueductal gray of rats.
Topics: Animals; Body Weight; Corticosterone; Enkephalins; Gene Expression Regulation; Injections, Subcutaneous; Male; Morphine; Naloxone; Periaqueductal Gray; Protein Precursors; Rats; Rats, Sprague-Dawley; Stress, Physiological; Substance Withdrawal Syndrome; Time Factors | 1998 |
Noribogaine stimulates naloxone-sensitive [35S]GTPgammaS binding.
Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Ibogaine; Logistic Models; Male; Naloxone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stimulation, Chemical; Sulfur Radioisotopes | 1998 |
Herpes virus-mediated preproenkephalin gene transfer to the amygdala is antinociceptive.
Topics: Amygdala; Animals; beta-Galactosidase; Enkephalins; Gene Transfer Techniques; Herpesviridae; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Protein Precursors; Rats | 1998 |
The regulating manner of opioid receptors on distinct types of calcium channels in hamster submandibular ganglion cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium Channels; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Parasympathetic; Male; Naloxone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Submandibular Gland; Synaptic Transmission | 1998 |
Immunohistochemistry and secretory effects of leucine enkephalin in the isolated pig lacrimal gland.
Topics: Animals; Atropine; Enkephalin, Leucine; Eye Proteins; Female; Immunohistochemistry; In Vitro Techniques; Lacrimal Apparatus; Male; Naloxone; Neurons; Perfusion; Phentolamine; Propranolol; Swine; Theophylline | 1998 |
Differential regulation of the cloned kappa and mu opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cell Line; Cloning, Molecular; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Hormone Antagonists; Ion Channel Gating; Mice; Naloxone; Narcotic Antagonists; Peptides, Cyclic; Pituitary Gland; Potassium; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Somatostatin | 1998 |
Mu-opioid and GABA(B) receptors modulate different types of Ca2+ currents in rat nodose ganglion neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics, Opioid; Animals; Baclofen; Cadmium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA Agonists; GABA Antagonists; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Nifedipine; Nodose Ganglion; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Opioid, mu; Spider Venoms | 1998 |
Localized secretion of ATP and opioids revealed through single Ca2+ channel modulation in bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Antineoplastic Agents; Autocrine Communication; Barium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Cattle; Chromaffin Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exocytosis; Ion Channel Gating; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Opioid Peptides; Patch-Clamp Techniques; Peptides; Receptors, Opioid; Receptors, Purinergic; Spider Venoms; Suramin; Virulence Factors, Bordetella | 1998 |
3H-naloxone benzoylhydrazone binding in MOR-1-transfected Chinese hamster ovary cells: evidence for G-protein-dependent antagonist binding.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; CHO Cells; Cholera Toxin; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Naloxone; Narcotic Antagonists; Pertussis Toxin; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella | 1998 |
Inhibition of morphine tolerance and dependence by diazepam and its relation to mu-opioid receptors in the rat brain and spinal cord.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain Chemistry; Central Nervous System; Diazepam; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypnotics and Sedatives; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tritium | 1998 |
Activation of opioid receptors inhibits neuronal-like calcium channels, distal steps of secretion, and cell proliferation in human small cell lung carcinoma cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Bucladesine; Calcium Channels; Carcinoma, Small Cell; Cell Division; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Lung Neoplasms; Naloxone; Neurons; Receptors, Opioid, delta; Serotonin; Thapsigargin; Time Factors; Tumor Cells, Cultured | 1998 |
A leu-enkephalin depresses transmission from muscle and skin non-nociceptors to first-order feline spinal neurones.
Topics: Analgesics; Animals; Cats; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Leucine; Interneurons; Membrane Potentials; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Spinal Cord; Synaptic Transmission | 1998 |
Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Naloxone; Receptors, Cell Surface; Receptors, Opioid; Transfection | 1998 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
Synaptic effects of nitric oxide on enkephalinergic, GABAergic, and glutamatergic networks of the rat periaqueductal gray.
Topics: Animals; Bicuculline; Blood Pressure; Enkephalins; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Hydroxylamine; Imidazoles; Male; Membrane Potentials; Naloxone; Nerve Net; Neural Inhibition; Nitric Oxide; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Synapses | 1998 |
Modulation of volitional ethanol intake in the rat by central delta-opioid receptors.
Topics: Alcohol Drinking; Animals; Enkephalin, Leucine; Male; Naloxone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1998 |
Stimulation of endothelial angiotensin-converting enzyme by morphine via non-opioid receptor mediated processes.
Topics: Cells, Cultured; Endothelium, Vascular; Enkephalins; Humans; Ligands; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Peptidyl-Dipeptidase A; Receptors, Opioid; Stimulation, Chemical | 1998 |
Involvement of mu-receptor in endogenous opioid peptide-mediated inhibition of acetylcholine release from the rat stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; beta-Endorphin; Electric Stimulation; Enkephalins; Gastric Mucosa; In Vitro Techniques; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid, mu; Stomach; Vagus Nerve | 1998 |
The effect of pentylenetetrazol kindling on synaptic mechanisms of interacting glutamatergic and opioid system in the hippocampus of rats.
Topics: Animals; Convulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Opioid; Seizures; Synapses | 1998 |
Opioid effects on activation of neurons in the medial prefrontal cortex.
Topics: Acetylcholine; Amygdala; Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamic Acid; Hippocampus; Male; Morphine; Naloxone; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Thalamus | 1998 |
The role of nitric oxide in the development of opioid withdrawal induced by naloxone after acute treatment with mu- and kappa-opioid receptor agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Narcotic Antagonists; Narcotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Vasodilator Agents | 1998 |
Effects of DPDPE (a specific delta-opioid receptor agonist) and naloxone on hypothalamic monoamine concentrations during the pre-ovulatory LH surge in the rat.
Topics: Animals; Biogenic Monoamines; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Follicular Phase; Hypothalamus; Luteinizing Hormone; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1998 |
Effect of naloxone on the bladder activity of rabbits with acute spinal injury.
Topics: Animals; Disease Models, Animal; Electromyography; Enkephalins; Injections, Intravenous; Injections, Spinal; Male; Naloxone; Prospective Studies; Rabbits; Spinal Cord Injuries; Time Factors; Urinary Bladder; Urodynamics | 1998 |
Enkephalin receptors and receptor-mediated signal transduction in cultured human lymphocytes.
Topics: Calcium; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Lymphocytes; Naloxone; Receptors, Opioid; Signal Transduction | 1999 |
The nociceptin receptor-mediated inhibition of the rat rostral ventrolateral medulla neurons in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; In Vitro Techniques; Male; Medulla Oblongata; Naloxone; Narcotic Antagonists; Neural Pathways; Neurons; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1999 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Effects of peptidase inhibitors, [D-Ala2, Met5]-enkephalinamide and antiserum to methionine-enkephalin microinjected into the caudal periaqueductal gray on morphine withdrawal in rats.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Immune Sera; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Periaqueductal Gray; Protease Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome | 1998 |
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists.
Topics: Analgesics; Analgesics, Opioid; Binding, Competitive; Biological Transport; Carcinogens; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Humans; Kinetics; Membrane Proteins; Morphine; Naloxone; Narcotic Antagonists; Neuroblastoma; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Opioid, mu; Second Messenger Systems; Time Factors; Tritium; Tumor Cells, Cultured | 1999 |
Inactivation of the purified bovine mu opioid receptor by sulfhydryl reagents.
Topics: Animals; Benzomorphans; Cattle; Cell Membrane; Corpus Striatum; Cysteine; Dithionitrobenzoic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylmaleimide; Kinetics; Ligands; Naloxone; Radioligand Assay; Receptors, Opioid, mu; Sulfhydryl Reagents; Tritium | 1999 |
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus | 1999 |
Stimulation of phospholipase C by the cloned mu, delta and kappa opioid receptors via chimeric G alpha(q) mutants.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cloning, Molecular; COS Cells; DNA, Complementary; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Type C Phospholipases | 1999 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
Mu opioids enhance mossy fiber synaptic transmission indirectly by reducing GABAB receptor activation.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA Antagonists; Long-Term Potentiation; Male; Membrane Potentials; Mossy Fibers, Hippocampal; Naloxone; Narcotic Antagonists; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Opioid, mu; Somatostatin; Synaptic Transmission | 1999 |
Characterization of mechanical withdrawal responses and effects of mu-, delta- and kappa-opioid agonists in normal and mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Physical Stimulation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Substance Withdrawal Syndrome | 1999 |
Differences in opioidergic inhibition of spinal reflexes and Fos expression evoked by mechanical and chemical noxious stimuli in the decerebrated rabbit.
Topics: Animals; Colchicine; Decerebrate State; Electric Stimulation; Enkephalins; Female; Gene Expression Regulation; Genes, fos; Image Processing, Computer-Assisted; Irritants; Male; Motor Neurons; Muscle Contraction; Muscle, Skeletal; Mustard Plant; Naloxone; Narcotic Antagonists; Nerve Crush; Nerve Tissue Proteins; Nociceptors; Plant Extracts; Plant Oils; Proto-Oncogene Proteins c-fos; Rabbits; Receptors, Opioid; Reflex; Stress, Mechanical; Toes | 1999 |
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection | 1998 |
Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ion Channel Gating; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1999 |
Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Mutagenesis, Site-Directed; Naloxone; Peptide Fragments; Peptides; Protein Structure, Secondary; Rats; Receptors, Opioid, mu; Somatostatin; Transfection | 1999 |
Activation of spinal opioid receptors contributes to hypotension after hemorrhage in conscious rats.
Topics: Animals; Blood Pressure; Consciousness; Dynorphins; Endorphins; Enkephalin, Leucine; Heart Rate; Hemorrhage; Hypotension; Male; Naloxone; Narcotic Antagonists; Neural Inhibition; Rats; Rats, Inbred WKY; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Sympathetic Nervous System | 1999 |
Opioid peptides inhibit the action of oestradiol on human myometrial cells in culture.
Topics: Adult; Cell Division; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Estradiol; Female; Humans; Inhibitory Concentration 50; Muscle, Smooth; Myometrium; Naloxone; Narcotic Antagonists; Progesterone | 1999 |
Differential desensitization of human delta-opioid receptors by peptide and alkaloid agonists.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Analgesics; Analgesics, Opioid; Cyclic AMP; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Humans; Naloxone; Neuroblastoma; Oligopeptides; Peptides; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Enkephalin regulates acute D2 dopamine receptor antagonist-induced immediate-early gene expression in striatal neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Corpus Striatum; DNA Primers; DNA-Binding Proteins; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Early Growth Response Protein 1; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; In Situ Hybridization; Male; Molecular Sequence Data; Naloxone; Neurons; Oligopeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Salicylamides; Transcription Factors; Transcriptional Activation | 1999 |
Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Pain; Receptors, Opioid, mu; Time Factors | 1999 |
Mechanism underlying increased neuronal activity in the rat ventrolateral periaqueductal grey by a mu-opioid.
Topics: Analgesics, Opioid; Animals; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; In Vitro Techniques; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Long-Evans; Rats, Wistar; Receptors, Opioid, mu | 1999 |
Changes in nociceptive and anxiolytic responses following herpes virus-mediated preproenkephalin overexpression in rat amygdala are naloxone-reversible and transient.
Topics: Amygdala; Animals; Anti-Anxiety Agents; beta-Galactosidase; Diazepam; Enkephalins; Gene Expression Regulation; Genetic Vectors; Herpesviridae; Humans; Male; Maze Learning; Naloxone; Pain; Pain Measurement; Protein Precursors; Rats; Recombinant Proteins; RNA, Messenger; Transcription, Genetic | 1999 |
Effects of naloxone on neurohypophyseal peptide release by hypertonic stimulation in chicks.
Topics: Analgesics, Opioid; Animals; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypertonic Solutions; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Osmolar Concentration; Oxytocin; Pituitary Gland, Posterior; Stimulation, Chemical; Vasotocin | 1999 |
Dopamine-opiate interaction in the regulation of neostriatal and pallidal neuronal activity as assessed by opioid precursor peptides and glutamate decarboxylase messenger RNA expression.
Topics: Animals; Dopamine; Dopamine Antagonists; Dynorphins; Enkephalins; Globus Pallidus; Glutamate Decarboxylase; Haloperidol; Male; Naloxone; Narcotic Antagonists; Neostriatum; Neurons; Opioid Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, mu; RNA, Messenger | 1999 |
Opioid modulation of calcium current in cultured sensory neurons: mu-modulation of baroreceptor input.
Topics: Aging; Analgesics, Opioid; Animals; Animals, Newborn; Calcium; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Naloxone; Narcotic Antagonists; Narcotics; Neurons, Afferent; Nodose Ganglion; Pressoreceptors; Rats; Receptors, Opioid, mu | 1999 |
Effects of diethylstilbestrol on mouse hippocampal evoked potentials in vitro.
Topics: Animals; Binding, Competitive; Dactinomycin; Diethylstilbestrol; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Excitatory Postsynaptic Potentials; Hippocampus; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Pyramidal Cells; Receptors, Opioid; Receptors, Opioid, mu | 1999 |
Opioids modulate cell division in the germinal zone of the late embryonic neocortex.
Topics: Animals; Benzomorphans; Cell Division; Cerebral Ventricles; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Mice; Mice, Inbred CBA; Mitotic Index; Naloxone; Narcotic Antagonists; Narcotics; Neocortex; Pregnancy; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Differences in the opioid system in selected brain regions of alcohol-preferring and alcohol-nonpreferring rats.
Topics: Alcoholism; Animals; Basal Ganglia; Brain Mapping; Breeding; Enkephalins; Genetic Markers; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Rats; Receptors, Opioid; RNA, Messenger | 1999 |
Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the delta-opioid receptor.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Substitution; Animals; Aspartic Acid; Binding, Competitive; Chlorocebus aethiops; Codon; Colforsin; COS Cells; Cyclic AMP; Diprenorphine; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ligands; Mice; Mutagenesis, Site-Directed; Naloxone; Pertussis Toxin; Point Mutation; Protein Binding; Receptors, Opioid, delta; Recombinant Fusion Proteins; Second Messenger Systems; Transfection; Virulence Factors, Bordetella | 1999 |
Morphine coupling to invertebrate immunocyte nitric oxide release is dependent on intracellular calcium transients.
Topics: Animals; Bivalvia; Calcium; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fura-2; Hemocytes; Kinetics; Morphine; Naloxone; Narcotic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Signal Transduction | 1999 |
Electrophysiological effects of opioid receptor activation on Syrian hamster suprachiasmatic nucleus neurones in vitro.
Topics: Action Potentials; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Cricetinae; Enkephalin, Leucine; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Suprachiasmatic Nucleus; Time Factors | 1999 |
Met5-enkephalin protects isolated adult rabbit cardiomyocytes via delta-opioid receptors.
Topics: Animals; beta-Endorphin; Cell Hypoxia; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Ischemic Preconditioning; Male; Models, Cardiovascular; Morphine; Myocardial Ischemia; Myocardium; Naloxone; Rabbits; Rats; Receptors, Opioid, delta | 1999 |
Overexpression of proenkephalin in the amygdala potentiates the anxiolytic effects of benzodiazepines.
Topics: Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents; beta-Galactosidase; Defective Viruses; Diazepam; DNA, Complementary; Enkephalins; Gene Transfer Techniques; Herpesvirus 4, Human; Humans; In Situ Hybridization; Maze Learning; Naloxone; Protein Precursors; Rats; Rats, Long-Evans; RNA, Messenger | 2000 |
Analgesic effect of interferon-alpha via mu opioid receptor in the rat.
Topics: Analgesia; Animals; Antibodies, Monoclonal; Cell Line; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Injections, Intraventricular; Interferon Type I; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Proteins | 2000 |
Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.
Topics: Analgesics, Opioid; Animals; Antimetabolites; Apoptosis; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Mice; Microscopy, Electron; Morphine; Naloxone; Narcotic Antagonists; Neurites; Neurons; Oligopeptides; Opioid-Related Disorders; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Stem Cells | 2000 |
mu-Opioid receptor inhibits N-type Ca2+ channels in the calyx presynaptic terminal of the embryonic chick ciliary ganglion.
Topics: Analgesics, Opioid; Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Chick Embryo; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Excitatory Postsynaptic Potentials; Ganglia, Parasympathetic; Naloxone; Narcotic Antagonists; Neural Inhibition; omega-Conotoxin GVIA; Patch-Clamp Techniques; Presynaptic Terminals; Receptors, Opioid, mu; Synaptic Transmission | 2000 |
Leu-enkephalin induced by IL-2 administration mediates analgesic effect of IL-2.
Topics: Analgesics; Animals; Enkephalin, Leucine; Humans; Injections, Intraventricular; Interleukin-2; Lateral Ventricles; Male; Naloxone; Narcotic Antagonists; Neuroimmunomodulation; Pain Threshold; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2000 |
Synaptic actions of neuropeptide FF in the rat parabrachial nucleus: interactions with opioid receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Ligands; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Patch-Clamp Techniques; Peptides; Picrotoxin; Pons; Potassium; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Tetrahydroisoquinolines; Tetrodotoxin | 2000 |
Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Gene Expression; In Situ Hybridization; Male; Morphine; Naloxone; Narcotic Antagonists; Neostriatum; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Running; Species Specificity; Substance P | 2000 |
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans.
Topics: Acids; Analgesics; Analgesics, Opioid; Animals; Cell Differentiation; CHO Cells; Cricetinae; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Fentanyl; Humans; Naloxone; Narcotic Antagonists; Neuroblastoma; Neurons; Tumor Cells, Cultured | 2001 |
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration.
Topics: Analgesics; Animals; Cats; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Mice; Naloxone; Narcotic Antagonists; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiration | 2001 |
Role of endogenous opioid peptides in protection of ischemic preconditioning in rat small intestine.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Edema; Enkephalin, Leucine; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Ischemia; Ischemic Preconditioning; L-Lactate Dehydrogenase; Male; Malondialdehyde; Morphine; Naloxone; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Wistar; Receptors, Opioid; Reperfusion Injury | 2001 |
Effects of spinorphin and tynorphin on synaptic transmission in rat hippocampal slices.
Topics: Animals; Enkephalins; Hippocampus; Long-Term Potentiation; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Protease Inhibitors; Rats; Rats, Wistar; Synaptic Transmission | 2001 |
The opioid peptide analogue biphalin induces less physical dependence than morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Enkephalins; Infusions, Intravenous; Male; Morphine; Morphine Dependence; Naloxone; Pentazocine; Rats; Rats, Sprague-Dawley; Substance-Related Disorders; Weight Loss | 2001 |
Cytotoxic effects of dynorphins through nonopioid intracellular mechanisms.
Topics: Apoptosis; Cation Exchange Resins; Cell Compartmentation; Cell Survival; Central Nervous System; Cytoplasm; Cytotoxins; Dynorphins; Enkephalins; Immunohistochemistry; Lipids; Naloxone; Narcotic Antagonists; Nerve Degeneration; Peptide Fragments; Protein Precursors; Protein Structure, Tertiary; Receptors, Opioid; Receptors, Opioid, kappa; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Naloxone blocks transferred preconditioning in isolated rabbit hearts.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Hemodynamics; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardium; Naloxone; Rabbits; Radioimmunoassay; Random Allocation | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice.
Topics: Analgesics; Animals; Drug Synergism; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Naloxone; Neprilysin; Nociceptors; Oligopeptides; Opioid Peptides; Pain Measurement; Pain Threshold; Protease Inhibitors | 2001 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Calcium; Embryo, Mammalian; Enkephalins; Ganglia, Spinal; GTP-Binding Proteins; Humans; In Situ Hybridization; Ligands; Molecular Sequence Data; Naloxone; Narcotic Antagonists; Neurons, Afferent; Nociceptors; Opioid Peptides; Phylogeny; Protein Binding; Protein Precursors; Rats; Receptors, Cell Surface; Sequence Alignment; Tissue Distribution | 2002 |
The role of leucine-enkephalin on insulin and glucagon secretion from pancreatic tissue fragments of normal and diabetic rats.
Topics: Animals; Atropine; Diabetes Mellitus, Experimental; Enkephalin, Leucine; Glucagon; Insulin; Insulin Secretion; Naloxone; Pancreas; Rats; Yohimbine | 2001 |
Design, synthesis, and evaluation of opioid analogues with non-peptidic beta-turn scaffold: enkephalin and endomorphin mimetics.
Topics: Enkephalins; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Naloxone; Narcotics; Oligopeptides; Peptide Biosynthesis; Peptide Library; Peptides; Protein Conformation; Protein Structure, Secondary; Receptors, Opioid; Time Factors | 2002 |
[Familial indifference to pain with somatosensory asymmetry: possible central anomaly].
Topics: Adolescent; Adult; Child; Cold Temperature; Dental Pulp; Dominance, Cerebral; Electric Stimulation; Electrophysiology; Enkephalins; Evoked Potentials, Somatosensory; Female; Hand; Hot Temperature; Humans; Laser-Doppler Flowmetry; Male; Middle Aged; Motor Neurons; Myelin Sheath; Naloxone; Neural Conduction; Neurons, Afferent; Pain Insensitivity, Congenital; Reflex; Sensory Thresholds; Skin Temperature; Substantia Gelatinosa; Ulnar Nerve | 2002 |
Naloxone reduces levodopa-induced dyskinesias and apomorphine-induced rotations in primate models of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benserazide; Callithrix; Dopamine; Dopamine Agents; Dopamine Antagonists; Dyskinesia, Drug-Induced; Enkephalins; Female; In Situ Hybridization; Levodopa; Male; Motor Activity; Naloxone; Narcotic Antagonists; Oxidopamine; Parkinson Disease, Secondary; Protein Precursors; RNA; Rotation; Stereotyped Behavior; Sympathectomy, Chemical | 2002 |
The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells.
Topics: Benzeneacetamides; Cell Division; Cell Survival; Colorimetry; DNA Fragmentation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Humans; Leukemia; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2002 |
Methionine-enkephalin and leucine-enkephalin increase interleukin-1 beta release in mixed glia cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Enkephalin, Leucine; Enkephalin, Methionine; Interleukin-1; Lipopolysaccharides; Naloxone; Narcotic Antagonists; Neuroglia; Rats; Rats, Wistar | 2002 |
Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain.
Topics: Animals; Area Under Curve; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalins; Ganglia, Spinal; Genetic Vectors; Immunohistochemistry; Ligation; Male; Morphine; Naloxone; Narcotic Antagonists; Oncogene Proteins v-fos; Pain; Pain Measurement; Pain Threshold; Protein Precursors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Simplexvirus; Spinal Cord Diseases; Time Factors; Transgenes | 2003 |
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2003 |
Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons.
Topics: Analgesics, Opioid; Animals; Arsenicals; Dose-Response Relationship, Drug; Drug Interactions; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Guinea Pigs; Ileum; Immunohistochemistry; Ligands; Microscopy, Confocal; Naloxone; Narcotic Antagonists; Neurons; Organ Culture Techniques; Potassium; Receptors, Opioid, mu; Somatostatin; Sucrose; Time Factors | 2003 |
Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Decanoic Acids; Disease Models, Animal; Drug Antagonism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Hydroxy Acids; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Naloxone; Potassium Channels; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, delta; Sclerosis; Ventricular Fibrillation | 2003 |
Developmental changes in the inhibition of cultured rat uterine cell proliferation by opioid peptides.
Topics: Aging; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Epidermal Growth Factor; Estradiol; Female; Inhibitory Concentration 50; Naloxone; Narcotic Antagonists; Opioid Peptides; Ovariectomy; Rats; Rats, Inbred Strains; Rats, Wistar; Uterus | 2003 |
The selective action of opioid peptides on excitability and the various sensory inputs of defensive behavior command neurons LPl1 and RPl1 of the common snail.
Topics: Action Potentials; Animals; Cell Membrane; Enkephalin, Leucine; Enkephalin, Methionine; Escape Reaction; Helix, Snails; Naloxone; Narcotic Antagonists; Neuronal Plasticity; Neurons; Opioid Peptides; Physical Stimulation; Quinine | 2003 |
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro.
Topics: Action Potentials; Adenosine; Affinity Labels; Animals; Colforsin; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Enkephalins; Enzyme Inhibitors; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Probenecid; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Substance Withdrawal Syndrome; Sulfonamides; Synaptic Transmission; Thioinosine; Time Factors; Uricosuric Agents; Vasodilator Agents; Xanthines | 2003 |
Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices.
Topics: Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; Female; Male; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Tetrodotoxin; Time Factors | 2003 |
Analgesia induced by dietary restriction is mediated by the kappa-opioid system.
Topics: Analgesia; Animals; Behavior, Animal; Body Weight; Enkephalins; Fasting; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Spinal Cord | 2003 |
Stress applied during primary immunization affects the secondary humoral immune response in the rat: involvement of opioid peptides.
Topics: Animals; Antibodies; Antibody Formation; Cattle; Electroshock; Enkephalin, Leucine; Enkephalin, Methionine; Immunity; Immunization; Immunization, Secondary; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Wistar; Serum Albumin, Bovine; Stress, Physiological; Stress, Psychological | 2003 |
A possible role for an enkephalinergic system in the internal defense mechanism of Biomphalaria alexandrina exposed to Schistosoma mansoni.
Topics: Animals; Biomphalaria; Blood Cell Count; Disease Susceptibility; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hemocytes; Host-Parasite Interactions; Naloxone; Narcotic Antagonists; Phagocytosis; Receptors, Opioid; Schistosoma mansoni | 2003 |
Enkephalinergic involvement in substantia nigra in the modulation of hypothalamically-induced predatory attack behavior.
Topics: Aggression; Animals; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Enkephalin, Methionine; Enkephalins; Female; Hypothalamus; Male; Microinjections; Naloxone; Narcotic Antagonists; Predatory Behavior; Substantia Nigra | 2003 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
The cardiovascular and renal effects of a highly potent mu-opioid receptor agonist, cyclo[N epsilon,N beta-carbonyl-D-Lys2,Dap5]enkephalinamide.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalins; Heart Rate; Kidney; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2004 |
Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice.
Topics: Animals; Benzodiazepinones; Disease Models, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Gene Expression; Hyperalgesia; Inflammation; Ligation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Phenylurea Compounds; Pro-Opiomelanocortin; Protein Precursors; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Neuropathy; Time Factors | 2004 |
Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn.
Topics: Animals; Cattle; Cell Count; Drug Interactions; Enkephalin, Methionine; Enkephalins; Formaldehyde; Gene Expression Regulation; Hot Temperature; Immunohistochemistry; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pain; Pain Measurement; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2004 |
Differential mechanisms of antianalgesia induced by endomorphin-1 and endomorphin-2 in the ventral periaqueductal gray of the rat.
Topics: Analgesia; Animals; beta-Endorphin; Cholecystokinin; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Morphine; Naloxone; Oligopeptides; Periaqueductal Gray; Rats; Receptors, Opioid, mu; Substance P | 2005 |
Species-specific effects on hemolymph glucose control by serotonin, dopamine, and L-enkephalin and their inhibitors in Squilla mantis and Astacus leptodactylus (crustacea).
Topics: Analysis of Variance; Animals; Blood Glucose; Decapoda; Domperidone; Dopamine; Dopamine Antagonists; Enkephalins; Hemolymph; Naloxone; Serotonin; Serotonin Antagonists; Species Specificity | 2004 |
Hypotensive effect of novel chimeric peptides of met-enkephalin and FMRFa.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; FMRFamide; Heart Rate; Hypotension; Male; Naloxone; Neuropeptides; Peptides; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Opioid; Vasodilator Agents | 2005 |
Analgesic activity of enkephalins following intracerebral administration in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Antagonism; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Tail | 1977 |
Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons.
Topics: Animals; Disease Models, Animal; Enkephalins; Genetic Therapy; Male; Naloxone; Narcotic Antagonists; Neurons; Pain Threshold; Protein Precursors; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simplexvirus; Transcriptional Activation; Trigeminal Ganglion; Trigeminal Neuralgia | 2005 |
Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; beta-Endorphin; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalins; Lithium Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Protein Precursors; Reaction Time | 2005 |
Endogenous opioids and attenuated hypothalamic-pituitary-adrenal axis responses to immune challenge in pregnant rats.
Topics: Adrenocorticotropic Hormone; Age Factors; Analysis of Variance; Animals; Cell Count; Chromatography, High Pressure Liquid; Corticotropin-Releasing Hormone; Drug Interactions; Enkephalins; Female; Gene Expression Regulation, Developmental; Hypothalamo-Hypophyseal System; Immunohistochemistry; In Situ Hybridization; Interleukin-1; Lipopolysaccharides; Microdialysis; Naloxone; Narcotic Antagonists; Narcotics; Oncogene Proteins v-fos; Pituitary-Adrenal System; Pregnancy; Pro-Opiomelanocortin; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Solitary Nucleus; Time Factors | 2005 |
Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.
Topics: Amisulpride; Animals; Behavior, Animal; Disulfides; Dopamine Antagonists; Enkephalins; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Sulpiride; Swimming | 2005 |
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin | 2005 |
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors | 2005 |
Naloxone's suppression of spontaneous and food-conditioned locomotor activity is diminished in mice lacking either the dopamine D(2) receptor or enkephalin.
Topics: Animals; Conditioning, Classical; Crosses, Genetic; Enkephalins; Feeding Behavior; Genotype; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Naloxone; Receptors, Dopamine D2 | 2005 |
Modulation of cardiovascular excitatory responses in rats by transcutaneous magnetic stimulation: role of the spinal cord.
Topics: Afferent Pathways; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Electroacupuncture; Enkephalin, Leucine; Magnetics; Male; Median Nerve; Naloxone; Neurotransmitter Agents; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Spinal Cord; Stomach; Sympathetic Nervous System | 2006 |
Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing acupuncture analgesia in the rat.
Topics: Acupuncture Analgesia; Animals; Arginine Vasopressin; Dynorphins; Electroacupuncture; Enkephalin, Leucine; Glutamic Acid; Injections, Intraventricular; Male; Microinjections; Naloxone; Narcotic Antagonists; Neurons; Opioid Peptides; Oxytocin; Pain Threshold; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2006 |
Delta and mu opioid receptors from the brain of a urodele amphibian, the rough-skinned newt Taricha granulosa: cloning, heterologous expression, and pharmacological characterization.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Endorphin; Brain Chemistry; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Molecular Sequence Data; Naloxone; Phylogeny; Receptors, Opioid, delta; Receptors, Opioid, mu; Salamandridae; Sequence Alignment | 2006 |
Kappa opioid control of seizures produced by a virus in an animal model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blotting, Northern; Borna Disease; Cell Survival; Disease Models, Animal; Dynorphins; Electroencephalography; Encephalitis, Viral; Enkephalins; Hippocampus; Male; Naloxone; Narcotic Antagonists; Neurons; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa; Seizures | 2006 |
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Corpus Striatum; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Exploratory Behavior; Male; Mice; Mice, Knockout; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Receptor, Adenosine A2A; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome | 2006 |
Opioid peptides and receptors in joint tissues: study in the rat.
Topics: Analgesics, Opioid; Animals; Brain; Dextrorphan; Dynorphins; Enkephalins; Joints; Levorphanol; Microscopy, Fluorescence; Naloxone; Periosteum; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Opioid; Stifle; Synovial Membrane; Tritium | 2006 |
Opioid peptides as possible neuromodulators in the frog peripheral nerve system.
Topics: Action Potentials; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Rana ridibunda; Sciatic Nerve | 2007 |
Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Feeding Behavior; Gene Expression Regulation; Globus Pallidus; Immunohistochemistry; Male; Naloxone; Narcotic Antagonists; Neural Pathways; Nucleus Accumbens; Oncogene Proteins v-fos; Rats; Rats, Sprague-Dawley; Reward; Taste | 2007 |
[Biological mechanisms of the individual variability of the anxiolytic action of opioids].
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain Chemistry; Disease Models, Animal; Enkephalins; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid | 2007 |
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
Topics: Acid Sensing Ion Channels; Analgesics; Animals; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Membrane Proteins; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Pain; Pain Measurement; Peptides; Protein Precursors; Reaction Time; Sodium Channels; Spider Venoms; Spinal Cord; Time Factors | 2007 |
Two-photon excitation fluorescence cross-correlation assay for ligand-receptor binding: cell membrane nanopatches containing the human micro-opioid receptor.
Topics: Animals; Cell Line; Cell Membrane; Cross-Linking Reagents; Enkephalin, Leucine; Fluorescein; Humans; Ligands; Molecular Structure; Naloxone; Naltrexone; Nanostructures; Narcotic Antagonists; Photons; Quantum Dots; Receptors, Opioid; Solutions; Spodoptera; Titrimetry | 2007 |
Enkephalin release promotes homeostatic increases in constitutively active mu opioid receptors during morphine withdrawal.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Operant; Data Interpretation, Statistical; Enkephalins; Homeostasis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2007 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger | 2008 |
Possible autocrine enkephalin regulation of catecholamine release in human pheochromocytoma cells.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Anti-Inflammatory Agents; Autocrine Communication; Catecholamines; Cell Separation; Cell Survival; Cells, Cultured; Child; Culture Media; Dexamethasone; Enkephalin, Methionine; Enkephalins; Female; Humans; Indicators and Reagents; Male; Middle Aged; Naloxone; Narcotic Antagonists; Pheochromocytoma | 2008 |
Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Enkephalins; Ganglia, Spinal; Gene Transfer Techniques; Genetic Vectors; Ligation; Lumbar Vertebrae; Male; Morphine; Morphine Dependence; Naloxone; Pain Threshold; Peripheral Nervous System Diseases; Protein Precursors; Rats; Rats, Sprague-Dawley; Simplexvirus; Spinal Nerve Roots; Substance Withdrawal Syndrome; Transgenes | 2009 |
Binding studies of novel, non-mammalian enkephalins, structures predicted from frog and lungfish brain cDNA sequences.
Topics: Analgesics, Opioid; Animals; Anura; Base Sequence; Brain; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fishes; Guanosine 5'-O-(3-Thiotriphosphate); Naloxone; Narcotic Antagonists; Opioid Peptides; Protein Binding; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 2009 |
Respiratory and cardiovascular effects of biphalin in anaesthetized rats.
Topics: Analgesics; Animals; Blood Pressure; Bradycardia; Cardiovascular System; Chloralose; Enkephalins; Heart Rate; Male; Naloxone; Rats; Rats, Wistar; Receptors, Opioid; Respiratory System; Time Factors; Urethane; Vagotomy | 2009 |
Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Area Under Curve; Blotting, Western; Dopamine; Enkephalins; Gene Expression; Genes, fos; Mice; Mice, Knockout; Microdialysis; Motor Activity; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Substance Withdrawal Syndrome | 2009 |
Amyloid-beta production in aged guinea pigs: atropine-induced enhancement is reversed by naloxone.
Topics: Aging; Amyloid beta-Peptides; Animals; Atropine; Cerebral Cortex; Enkephalins; Guinea Pigs; Male; Muscarinic Antagonists; Naloxone; Narcotic Antagonists | 2010 |
Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration.
Topics: Analgesia; Analgesics, Opioid; Animals; beta-Endorphin; Dynorphins; Enkephalins; Female; Hot Temperature; Mice; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Nociceptors; Opioid Peptides; Pain Measurement; Stress, Psychological; Swimming; Time Factors | 2011 |
Differentiation between Aδ and C fibre evoked nociceptive reflexes by TTX resistance and opioid sensitivity in the cat.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Excitatory Postsynaptic Potentials; Female; Foot; Male; Naloxone; Narcotic Antagonists; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Reflex; Spinal Cord; Tetrodotoxin | 2011 |
Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides.
Topics: Animals; beta-Endorphin; Catheterization; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Microinjections; Naloxone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Periaqueductal Gray; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 2011 |
Microdialysis and mass spectrometric monitoring of dopamine and enkephalins in the globus pallidus reveal reciprocal interactions that regulate movement.
Topics: Amino Acids; Amphetamine; Animals; Benzazepines; Central Nervous System Stimulants; Dopamine; Dopamine Antagonists; Drug Interactions; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Globus Pallidus; Male; Mass Spectrometry; Microdialysis; Motor Activity; Naloxone; Narcotic Antagonists; Raclopride; Rats; Rats, Sprague-Dawley | 2011 |
The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.
Topics: Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System | 2011 |
Microinjection of HSV-1 amplicon vector-mediated human proenkephalin into the periaqueductal grey attenuates neuropathic pain in rats.
Topics: Animals; Constriction, Pathologic; Enkephalin, Leucine; Enkephalins; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Humans; Hyperalgesia; Male; Microinjections; Naloxone; Narcotic Antagonists; Neuralgia; Pain Measurement; Pain Threshold; Periaqueductal Gray; Protein Precursors; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recombination, Genetic | 2012 |
The analgesic activity of biphalin and its analog AM 94 in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Pain; Piperazines; Rats; Rats, Wistar; Time Factors | 2012 |
Exposure to exogenous enkephalins disrupts reproductive development in the Eastern lubber grasshopper, Romalea microptera (Insecta: Orthoptera).
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Grasshoppers; Male; Naloxone; Oocytes; Ovary; Reproduction; Testis | 2012 |
Effects of herpes simplex virus vector-mediated enkephalin gene therapy on bladder overactivity and nociception.
Topics: Analgesics; Animals; Diterpenes; Enkephalins; Female; Ganglia, Spinal; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Interleukin-1beta; Interleukin-6; Naloxone; Nociception; Protein Precursors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simplexvirus; Urinary Bladder; Urinary Bladder, Overactive; Urinary Catheterization; Virus Replication; Visceral Pain | 2013 |
Modulation of male song by naloxone in the medial preoptic nucleus.
Topics: Analysis of Variance; Androgens; Animals; Enkephalins; Female; Male; Naloxone; Narcotic Antagonists; Photoperiod; Preoptic Area; Sexual Behavior, Animal; Starlings; Testosterone; Vocalization, Animal | 2013 |
The role of endogenous beta-endorphin and enkephalins in ethanol reward.
Topics: Animals; beta-Endorphin; Choice Behavior; Conditioning, Psychological; Dose-Response Relationship, Drug; Enkephalins; Ethanol; Female; Mice; Mice, Knockout; Naloxone; Narcotic Antagonists; Protein Precursors; Reward | 2013 |
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalins; Fentanyl; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward.
Topics: Analysis of Variance; Animals; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Dopamine; Enkephalins; Exploratory Behavior; Flow Cytometry; Green Fluorescent Proteins; Mice; Mice, Transgenic; Microdialysis; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neural Pathways; Neurons; Pain; Pain Measurement; Protein Precursors; Receptors, Opioid, mu; Reward; Substance Withdrawal Syndrome | 2014 |
Naloxone treatment alters gene expression in the mesolimbic reward system in 'junk food' exposed offspring in a sex-specific manner but does not affect food preferences in adulthood.
Topics: Animals; Diet, High-Fat; Dietary Sucrose; Dopamine Plasma Membrane Transport Proteins; Eating; Enkephalins; Feeding Behavior; Female; Food Preferences; Gene Expression Regulation; Male; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine; Reward; RNA, Messenger; Sex Characteristics; Ventral Tegmental Area | 2014 |
Desensitization of functional µ-opioid receptors increases agonist off-rate.
Topics: Analgesics, Opioid; Animals; Brain; Enkephalins; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kinetics; Ligands; Naloxone; Naltrexone; Photolysis; Potassium; Rats; Receptors, Opioid, mu | 2014 |
Antinociceptive effect of intrathecal microencapsulated human pheochromocytoma cell in a rat model of bone cancer pain.
Topics: Adrenal Gland Neoplasms; Alginates; Animals; Biocompatible Materials; Bone Neoplasms; Cell Transplantation; Enkephalins; Female; Humans; Naloxone; Nociceptive Pain; Norepinephrine; Pheochromocytoma; Polylysine; Rats; Rats, Sprague-Dawley; Spinal Cord; Yohimbine | 2014 |
Constant light suppresses production of Met-enkephalin-containing peptides in cultured splenic macrophages and impairs primary immune response in rats.
Topics: Animals; Circadian Rhythm; Cytokines; Down-Regulation; Enkephalin, Methionine; Enkephalins; Immunoglobulin M; Immunohistochemistry; Interleukin-2; Light; Macrophages; Male; Melatonin; Naloxone; Phenotype; Photoperiod; Protein Precursors; Rats; Rats, Wistar; Spleen | 2015 |
Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Enkephalins; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Nucleus Accumbens; Phosphorylation | 2016 |
Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral mediated enkephalin overproduction in male and female rats.
Topics: Animals; Disease Models, Animal; Enkephalins; Female; Herpesviridae; Herpesviridae Infections; Hyperalgesia; Male; Masseter Muscle; Naloxone; Narcotic Antagonists; Nociception; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Nuclei | 2015 |
GABA and enkephalin tonically alter sympathetic outflows in the rat spinal cord.
Topics: Adipose Tissue, Brown; Animals; Bicuculline; Blood Pressure; Body Temperature; Enkephalins; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Heart Rate; Male; Naloxone; Narcotic Antagonists; Protein Precursors; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger; Spinal Cord; Sympathetic Nervous System | 2015 |
[ROLE PHOSPHOINOSITID SIGNALING PATHWAY IN OPIOIDS CONTROL OF P2X3 RECEPTORS IN THE PRIMARY SENSORY NEURONS].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Enkephalins; Enzyme Inhibitors; Estrenes; Ganglia, Spinal; Gene Expression; Naloxone; Nociception; Nociceptors; Pain; Patch-Clamp Techniques; Pertussis Toxin; Phosphatidylinositols; Primary Cell Culture; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Purinergic P2X3; Signal Transduction; Staurosporine; Type C Phospholipases | 2015 |
Biphalin preferentially recruits peripheral opioid receptors to facilitate analgesia in a mouse model of cancer pain - A comparison with morphine.
Topics: Analgesia; Analgesics, Opioid; Animals; Blood-Brain Barrier; Cancer Pain; Cell Line, Tumor; Disease Models, Animal; Drug Tolerance; Enkephalins; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Opioid Peptides; Permeability; Quaternary Ammonium Compounds; Receptors, Opioid; Skin Neoplasms | 2016 |
Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain.
Topics: Analgesics; Animals; Bone Marrow Cells; Bone Neoplasms; Cancer Pain; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Enkephalins; Female; Genetic Therapy; Genetic Vectors; Humans; Hyperalgesia; Injections, Spinal; Naloxone; Pain Threshold; Protein Precursors; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation | 2017 |
Beta-endorphin inhibits the inflammatory response of bovine endometrial cells through δ opioid receptor in vitro.
Topics: Animal Husbandry; Animals; beta-Endorphin; Cattle; Cells, Cultured; Endometritis; Endometrium; Enkephalin, Leucine; Epithelial Cells; Escherichia coli; Female; Inflammation; Lipopolysaccharides; Naloxone; Narcotic Antagonists; NF-kappa B; Primary Cell Culture; Puerperal Infection; Receptors, Opioid, delta; Signal Transduction | 2021 |
Contribution of the μ opioid receptor and enkephalin to the antinociceptive actions of endomorphin-1 analogs with unnatural amino acid modifications in the spinal cord.
Topics: Analgesics; Animals; Chronic Pain; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Mice; Naloxone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu; Spinal Cord | 2021 |
Effects of intracerebroventricularly administered opioid peptide antagonists on tissue glycogen levels in rats after exercise
Topics: Animals; Enkephalins; Glycogen; Infusions, Intraventricular; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Opioid Peptides; Physical Conditioning, Animal; Rats; Receptors, Opioid, delta | 2021 |
Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief.
Topics: Acenaphthenes; Amphibian Proteins; Animals; Arthritis, Experimental; Corticotropin-Releasing Hormone; Enkephalins; Hyperalgesia; Interneurons; Male; Naloxone; Nociception; Pain; Peptide Hormones; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Spinal Cord; Urocortins | 2021 |
Supraspinal melatonin MT
Topics: Analgesics, Opioid; Animals; Enkephalins; Melatonin; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 2022 |
Endogenous opioid system modulates conditioned cocaine reward in a sex-dependent manner.
Topics: Analgesics, Opioid; Animals; Cocaine; Enkephalins; Female; Male; Mice; Naloxone; Narcotic Antagonists; Opioid Peptides; Reward | 2023 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |