enkephalin, leucine has been researched along with n,n-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine in 208 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 71 (34.13) | 18.7374 |
| 1990's | 105 (50.48) | 18.2507 |
| 2000's | 27 (12.98) | 29.6817 |
| 2010's | 4 (1.92) | 24.3611 |
| 2020's | 1 (0.48) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, ZG; North, RA | 1 |
| Bowen, WD; Farmer, SC; Mattia, A; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Bowen, WD; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Vanderah, TW; Wild, KD | 1 |
| Tang, RR; Tseng, LF | 1 |
| Bowen, WD; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Crook, TJ; Hill, RG; Kitchen, I | 1 |
| Cabral, JD; Leedham, JA; Monroe, PJ; Robertson, B; Smith, DJ; Taylor, DA | 1 |
| Ableitner, A; Schulz, R | 1 |
| Levine, JD; Miaskowski, C | 1 |
| Holman, RB; Widdowson, PS | 1 |
| Jhamandas, K; Ruzicka, BB | 1 |
| Froehlich, JC; Harts, J; Li, TK; Lumeng, L; Zweifel, M | 1 |
| Chalmers, J; Drolet, G; Morilak, DA | 2 |
| deCosta, B; Jiang, Q; Porreca, F; Rice, KC | 1 |
| Medzihradsky, F; Remmers, AE | 1 |
| Collins, JG; Kitahata, LM; Nakatani, K; Omote, K | 1 |
| Bilotta, JM; Brackeen, MF; Feldman, PL; James, MK; Leighton, HJ; Schuster, SV | 1 |
| Cagampang, FR; Maeda, K | 1 |
| Lu, CL; Shaikh, MB; Siegel, A | 1 |
| Bramham, CR; Milgram, NW; Srebro, B | 1 |
| Levine, JD; Miaskowski, C; Taiwo, YO | 1 |
| Collins, JG; Kitahata, LM; Nakagawa, I; Nakatani, K; Omote, K | 2 |
| Bauer, AJ; Szurszewski, JH | 1 |
| Shiotsu, G; Stein, L; Stevens, KE | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL | 1 |
| Duckles, SP; Li, YJ | 1 |
| Evans, RG; Ludbrook, J | 1 |
| Freye, E; Schenk, G; Schnitzler, M | 1 |
| Burnstock, G; Hoyle, CH; Kamm, MA; Lennard-Jones, JE | 1 |
| Gramsch, C; Hassan, AH; Herz, A; Parsons, CG; Peter, K; Przewlocki, R; Stein, C | 1 |
| Bals-Kubik, R; Herz, A; Shippenberg, TS | 3 |
| Amerini, S; Ledda, F; Mantelli, L; Rubino, A | 1 |
| Kromer, W | 1 |
| Suh, HH; Tseng, LF | 2 |
| Herz, A; Shippenberg, TS; Spanagel, R | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Martinez, JL; Schulteis, G | 1 |
| Jiang, Q; Mosberg, HI; Porreca, F | 1 |
| Costa, T; Gless, C; Herz, A; Lang, J | 1 |
| Daugé, V; Feger, J; Maldonado, R; Roques, BP | 1 |
| La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 2 |
| Chalmers, J; Drolet, G; Morilak, D | 1 |
| Fuentes, JA; Iglesias, T; Jiménez, I | 1 |
| Mosberg, HI; Porreca, F; Qi, JA | 1 |
| Burks, TF; Malarchik, ME; Moseberg, HI; Porreca, F; Rivière, PJ; Sheldon, RJ | 1 |
| Jiang, Q; Porreca, F; Tallarida, RJ | 1 |
| Chen, HT; Louie, DS; Owyang, C | 1 |
| Costa, T; Passarelli, F | 1 |
| Abbott, FV; Kunos, G; Mastrianni, JA | 1 |
| Alvarado, MC; Bennett, EL; Hruby, VJ; Martinez, JL; Patterson, TA; Rosenzweig, MR; Schulteis, G | 1 |
| Basbaum, AI; Levine, JD; Perry, F; Taiwo, YO | 1 |
| Buckingham, JC; Cover, PO | 1 |
| Costa, T; Herz, A | 1 |
| Kiritsy-Roy, JA; Marson, L; Van Loon, GR | 2 |
| Dickenson, AH; Roques, BP; Sullivan, AF | 1 |
| Cao, XD; He, XP | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Nunan, L; Porreca, F; Sheldon, RJ | 1 |
| Huidobro-Toro, JP; Li, CH; Valenzuela, R | 1 |
| Almeida, OF; Herz, A; Nikolarakis, KE; Yassouridis, A | 1 |
| Garzón, J; Sánchez-Blázquez, P; Ulibarri, I | 1 |
| Jackson, HC; Kitchen, I | 1 |
| de Witte, P; Heidbreder, C; Roques, BP | 1 |
| Starke, K; Szabo, B; Wichmann, T | 1 |
| Berzetei, IP; Duckles, SP; Yamamura, HI | 1 |
| Cunningham, FJ; Stansfield, SC | 1 |
| Kennedy, C; Krier, J | 2 |
| Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F | 1 |
| Widdowson, PS | 1 |
| Kunos, G; Mosqueda-Garcia, R | 1 |
| Browne, JL; Pilcher, CW | 1 |
| Smith, CB | 1 |
| Everitt, BJ; Herbert, J; Hughes, AM | 1 |
| Gesellchen, PD; Leander, JD; Mendelsohn, LG | 1 |
| Burks, TF; Hruby, VJ; Kazmierski, W; Lemcke, PK; Shook, JE; Wire, WS | 1 |
| Janković, BD; Marić, D | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Miller, L; Rance, MJ; Shaw, JS; Traynor, JR | 1 |
| Brenner, AS; Geppert, M; Illes, P; Jackisch, R | 1 |
| Kirby, GC; McQueen, DS | 1 |
| Cohen, ML; Gesellchen, PD; Osborne, JJ; Shuman, RT | 1 |
| Holaday, JW; Long, JB; Mobley, WC | 1 |
| Fujiwara, M; Kurahashi, K; Okamoto, T | 1 |
| Holaday, JW; Long, JB; Petras, JM | 1 |
| Long, JB; Tortella, FC | 1 |
| Cowan, A; Porreca, F; Zhu, XZ | 1 |
| Burks, TF; Hirning, LD; Hruby, VJ; Hurst, R; Mosberg, HI; Porreca, F | 1 |
| Dray, A; Nunan, L; Wire, W | 3 |
| Bicknell, RJ; Chapman, C; Leng, G | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Miller, L; Shaw, JS | 1 |
| Bettermann, R; Illes, P | 1 |
| Hansen, HA; Mulder, AH; Schoffelmeer, AN; Stoof, JC | 1 |
| Richards, ML; Sadeé, W | 1 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Dickenson, AH; Feeney, C; Fournie-Zaluski, MC; Roques, BP; Sullivan, A | 1 |
| Kotlińska, J; Langwiński, R | 1 |
| Carter, A; Smith, CF | 1 |
| Rezvani, A; Rhoads, DL; Stokes, KB; Way, EL | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Barnes, JC; Briggs, I | 1 |
| Clarke, RW; Ford, TW | 1 |
| Hart, SL; Slusarczyk, H; Smith, TW | 1 |
| Jackson, HC; Sewell, RD | 1 |
| Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 1 |
| Illes, P; Starke, K; Weitzell, R | 1 |
| Bennett-Kelly, L; Smith, CB; Woods, JH | 1 |
| Corbett, AD; Kosterlitz, HW; Marcoli, M; McKnight, AT | 1 |
| Glatt, CE; Holaday, JW; Long, JB; Ruvio, BA | 1 |
| Cotton, R; Giles, MG; Miller, L; Shaw, JS; Timms, D | 1 |
| Fujinami, T; Nishimura, M; Saeki, T; Sato, N; Watanabe, Y | 1 |
| Chen, C; Chen, YW; Kim de Riel, J; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Tripathi, A; Welch, SP | 1 |
| Dubrovina, NI | 2 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Janković, BD; Radulović, J | 1 |
| Almeida, OF; Shippenberg, TS; Spanagel, R | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Castro, MA; Garzón, J; Juarros, JL; Martínez-Peña, Y; Sánchez-Blázquez, P | 1 |
| Gozariu, L; Gozariu, MS; Orbai, P; Sandor, V; Schmidt-Gayk, H | 1 |
| Carter, L; Schäfer, M; Stein, C | 1 |
| Connelly, CD; Martinez, RP; Porreca, F; Raffa, RB; Schupsky, JJ | 1 |
| Chang, SL; Ge, LJ; Harrison, LM; Kastin, AJ; Zadina, JE | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Gonzalvez, ML; Milanés, MV; Vargas, ML | 1 |
| Cai, YP; Yu, LC | 2 |
| North, RA; Sugita, S | 1 |
| Hyytiä, P | 1 |
| Adloff, M; Angel, F; Chamouard, P; Klein, A; Martin, E | 1 |
| Castro, MA; Garzón, J; Juarros, JL; Sánchez-Blázquez, P | 1 |
| Ludbrook, J; Ventura, S | 1 |
| Cheĭdo, MA; Idova, GV | 1 |
| Colwell, DD; Kavaliers, M | 1 |
| Chang, KJ; Comer, SD; De Costa, BR; McNutt, RW; Mosberg, HI; Woods, JH | 1 |
| Innes, DG; Kavaliers, M | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Elliott, J; Traynor, JR | 1 |
| Welch, SP | 1 |
| Georgoussi, Z; Zioudrou, C | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Laban, O; Marković, BM; Radulović, J; Stanojević, S; Vasiljević, T | 1 |
| Dubrovina, NI; Ilyutchenok, RY | 1 |
| Carr, IC; Milligan, G; Mullaney, I | 1 |
| Endoh, T; Suzuki, T | 1 |
| Bianchi, M; Panerai, AE; Sacerdote, P | 1 |
| Chen, SF; Ghanta, VK; Hiramoto, RN; Hsueh, CM; Huang, HJ | 1 |
| Kovacević-Jovanović, V; Mancev, Z; Pesić, G; Radulović, J; Stanojević, S; Vasiljević, T | 1 |
| Chiu, TT; Wong, YH; Yung, LY | 1 |
| Chen, HS; Hu, DY; Liu, LM; Lu, RQ; Yan, W | 1 |
| Georgoussi, Z; Merkouris, M; Milligan, G; Mullaney, I | 1 |
| Szekeres, PG; Traynor, JR | 1 |
| Lishmanov, IuB; Maslov, LN; Ugdyzhekova, DS | 1 |
| Fingerman, M; Nagabhushanam, R; Sarojini, R | 1 |
| Bhargava, HN; House, RV; Thomas, PT | 1 |
| MacEwan, DJ; Mercouris, M; Milligan, G; Mullaney, I | 1 |
| Franck, J; Lindholm, S; Raaschou, P | 1 |
| Eriksson, PS; Hansson, E; Rönnbäck, L; Thorlin, T | 1 |
| Liu, H; Mazarati, A; Wasterlain, C | 1 |
| Arcaya, JL; Cano, G; Gómez, G; Maixner, W; Suárez-Roca, H | 1 |
| Lishmanov, IuB; Maĭmeskulova, LA; Maslov, LN; Uskina, EV | 1 |
| Kowalski, J | 1 |
| Ang, KK; Arnolda, LF; Chalmers, JP; Llewellyn-Smith, IJ; McRitchie, RJ; Minson, JB; Pilowsky, PM | 1 |
| Alfaro-Lopez, J; Burkey, TH; Hosohata, K; Hruby, VJ; Roeske, WR; Yamamura, HI | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Cui, RY; Jiang, CL; Liu, XY; Lu, CL; Son, LX; Sun, LY; Wang, YX; You, ZD | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Freeman, FM; Young, IG | 1 |
| Chen, ZW; Han, JS; Wang, Y; Yang, K | 1 |
| Kellett, E; McVey, M; Milligan, G; Pope, AJ; Ramsay, D; Rees, S; Wilson, S | 1 |
| Lishmanov, AY; Maslov, LN; Rebrova, TY; Tam, SV | 1 |
| Lishmanov, IuB; Maslov, LN; Rebrova, TIu; Tam, SV | 1 |
| Li, P; Longhurst, JC; Tjen-A-Looi, S | 1 |
| Carroll, FI; Evans, CJ; Keith, DE; Thomas, JB; Zaki, PA | 1 |
| Azzi, M; Bouvier, M; De Léan, A; Piñeyro, G; Schiller, P | 1 |
| Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB | 1 |
| Hong, X; Lin, B; Wang, C; Zhao, X | 1 |
| Gross, GJ; Krylatov, AV; Lasukova, TV; Lishmanov, YB; Maslov, LN; Stefano, GB | 1 |
| Gross, GJ; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stefano, GB; Tam, SW | 1 |
| Befort, K; Décaillot, FM; Filliol, D; Kieffer, BL; Lazarus, LH; Schiller, PW; Schmidhammer, H; Tryoen-Tóth, P | 1 |
| Audet, N; Landry-Paquet, O; Paquin-Gobeil, M; Piñeyro, G; Schiller, PW | 1 |
| Diao, YF; Li, P; Liao, ZF; Liu, JC; Liu, LM; Tian, KL; Zhou, R; Zhou, XW | 1 |
| Bespalova, ZhD; Lasukova, TV; Maslov, LN; Nagase, H; Oldgen, P; Rice, KK | 1 |
| Bagley, EE; Chieng, BC; Christie, MJ; Hack, SP | 1 |
| Christie, MJ; Connor, M; Marinelli, S; Schnell, SA; Vaughan, CW; Wessendorf, MW | 1 |
| Dan, FJ; Hu, DY; Liu, LM; Lu, RQ; Pan, XK | 1 |
| Hsiao, I; Lin, VW; Longhurst, JC; Zhou Yi Syuu, W | 1 |
| Kang-Park, MH; Kieffer, BL; Moore, SD; Roberts, AJ; Siggins, GR | 1 |
| Bernard, D; Coop, A; MacKerell, AD | 1 |
| Eriksson, S; Frithiof, R; Rundgren, M | 1 |
| Atwood, CS; Gallego, MJ; Kaltcheva, MM; Meethal, SV; Porayette, P | 1 |
| Cline, MA; Hiramatsu, K; Sugahara, K; Tachibana, T; Ueda, H | 1 |
| Balleine, BW; Cely, IC; Maidment, NT; Wassum, KM | 1 |
| Duranteau, J; Le Manach, Y | 1 |
| Ding, X; Li, T; Liu, L; Tian, K; Zhu, Y | 1 |
| Fujii, H; Higashi, E; Hirayama, S; Iihara, Y; Iwai, T; Nagase, H; Nemoto, T | 1 |
| Fujii, H; Hirayama, S | 1 |
3 review(s) available for enkephalin, leucine and n,n-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine
| Article | Year |
|---|---|
delta-Opioid receptor subtypes and cross-talk with mu-receptors.
Topics: Animals; Binding Sites; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Inverse agonism at adrenergic and opioid receptors: studies with wild type and constitutively active mutant receptors.
Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Enkephalin, Leucine; Humans; Mice; Receptors, Opioid, delta; Sotalol | 1997 |
δ Opioid Receptor Inverse Agonists and their In Vivo Pharmacological Effects.
Topics: Analgesics, Opioid; Enkephalin, Leucine; Humans; Receptors, Opioid, delta | 2020 |
205 other study(ies) available for enkephalin, leucine and n,n-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine
| Article | Year |
|---|---|
Pre- and postsynaptic inhibition by opioids in rat striatum.
Topics: Action Potentials; Animals; Corpus Striatum; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Male; Membrane Potentials; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synapses | 1992 |
Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype.
Topics: Affinity Labels; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Spinal Cord; Thiocyanates | 1992 |
Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse.
Topics: Analgesia; Animals; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Physical Exertion; Receptors, Opioid; Receptors, Opioid, delta; Swimming | 1992 |
Pentobarbital attenuates antinociception induced by i.c.v. morphine but not beta-endorphin in the mouse.
Topics: Animals; beta-Endorphin; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pentobarbital; Receptors, Opioid | 1992 |
Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
Opioid receptors mediating antinociception from beta-endorphin and morphine in the periaqueductal gray.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid | 1992 |
Neuroanatomical sites mediating the central actions of beta-endorphin as mapped by changes in glucose utilization: involvement of mu opioid receptors.
Topics: Animals; Autoradiography; Behavior, Animal; beta-Endorphin; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine; Glucose; Injections, Intraventricular; Male; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1992 |
Inhibition of spinal opioid analgesia by supraspinal administration of selective opioid antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Narcotic Antagonists; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Somatostatin | 1992 |
Ethanol-induced increase in endogenous dopamine release may involve endogenous opiates.
Topics: Animals; beta-Endorphin; Dopamine; Endorphins; Enkephalin, Leucine; Ethanol; Levodopa; Male; Naloxone; Narcotic Antagonists; Potassium; Rats; Rats, Inbred Strains | 1992 |
The K(+)-evoked release of [3H]acetylcholine from slices of rat globus pallidus: modulation by delta-opioid receptors.
Topics: Acetylcholine; Animals; Choline O-Acetyltransferase; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Globus Pallidus; In Vitro Techniques; Male; Narcotic Antagonists; Physostigmine; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Importance of delta opioid receptors in maintaining high alcohol drinking.
Topics: Alcohol Drinking; Animals; Drinking Behavior; Enkephalin, Leucine; Male; Naloxone; Narcotic Antagonists; Neprilysin; Phenylpropionates; Rats; Receptors, Opioid; Receptors, Opioid, delta; Thiorphan | 1991 |
Endogenous opioids tonically inhibit the depressor neurones in the caudal ventrolateral medulla of rabbits: mediation through delta- and kappa-receptors.
Topics: Amino Acid Sequence; Animals; Endorphins; Enkephalin, Leucine; Hemodynamics; Male; Medulla Oblongata; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1991 |
Effects of oxymorphindole on morphine induced-antinociception in mice and rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mice; Morphine; Morpholines; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Resolution of biphasic binding of the opioid antagonist naltrexone in brain membranes.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Male; Membranes; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes | 1991 |
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.
Topics: Alkylation; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Vas Deferens | 1991 |
Effects of intracerebroventricular administration of opiate receptor antagonists on the suppressed pulsatile LH release during acute fasting in ovariectomized estradiol-treated rats.
Topics: Animals; Azocines; Enkephalin, Leucine; Estradiol; Fasting; Female; Injections, Intraventricular; Luteinizing Hormone; Naloxone; Narcotic Antagonists; Ovariectomy; Periodicity; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
An enkephalinergic mechanism involved in amygdaloid suppression of affective defence behavior elicited from the midbrain periaqueductal gray in the cat.
Topics: Affect; Aggression; Amygdala; Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalins; Female; Fluorescent Dyes; Homocysteine; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Stilbamidines | 1991 |
Delta opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Evoked Potentials; Hippocampus; Male; Naloxone; Narcotic Antagonists; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, delta; Synapses; Synaptic Transmission; Time Factors | 1991 |
Contribution of supraspinal mu- and delta-opioid receptors to antinociception in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Narcotic Antagonists; Nociceptors; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Interaction between opiate subtype and alpha-2 adrenergic agonists in suppression of noxiously evoked activity of WDR neurons in the spinal dorsal horn.
Topics: Adrenergic alpha-Agonists; Animals; Anterior Horn Cells; Cats; Clonidine; Drug Interactions; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Effect of opioid peptides on circular muscle of canine duodenum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Muscles; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid | 1991 |
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration | 1991 |
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes | 1991 |
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1991 |
Effect of opioid receptor antagonists on vasodilator nerve actions in the perfused rat mesentery.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanethidine; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Vasodilation | 1991 |
Cardiac chemoreceptors: pharmacological curiosities or physiological tools?
Topics: Afferent Pathways; Animals; Biguanides; Chemoreceptor Cells; Enkephalin, Leucine; Heart; Hemodynamics; Mecamylamine; Narcotic Antagonists; Nicotine; Rabbits; Receptors, Opioid, delta; Serotonin Antagonists; Tropanes | 1991 |
Opioid-induced respiratory depression and analgesia may be mediated by different subreceptors.
Topics: Analgesia; Animals; Dogs; Enkephalin, Leucine; Evoked Potentials, Somatosensory; Fentanyl; Morphinans; Narcotics; Receptors, Opioid; Respiration | 1991 |
Enkephalins modulate inhibitory neuromuscular transmission in circular muscle of human colon via delta-opioid receptors.
Topics: Action Potentials; Adenosine Triphosphate; Aged; Aged, 80 and over; Colon; Depression, Chemical; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalins; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle, Smooth; Naloxone; Narcotic Antagonists; Neuromuscular Junction; Receptors, Opioid; Serotonin; Synaptic Transmission; Vasoactive Intestinal Peptide | 1990 |
Local opioid receptors mediating antinociception in inflammation: endogenous ligands.
Topics: Animals; Endorphins; Enkephalin, Leucine; Inflammation; Naloxone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
Involvement of central mu and delta opioid receptors in mediating the reinforcing effects of beta-endorphin in the rat.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Somatostatin | 1990 |
The antinociceptive role of mu- and delta-opiate receptors and their interactions in the spinal dorsal horn of cats.
Topics: Analgesics, Opioid; Animals; Cats; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ganglia, Spinal; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Characterization of opioid receptors modulating the function of capsaicin-sensitive neurons in guinea-pig atria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Benzomorphans; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Male; Morphine; Neurons; Pyrrolidines; Receptors, Opioid; Reserpine | 1990 |
Reflex peristalsis in the guinea pig isolated ileum is endogenously controlled by kappa opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peristalsis; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Somatostatin | 1990 |
Tonic opioid inhibition of the pressor region of the rostral ventrolateral medulla of rabbits is mediated by delta receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Hemodynamics; Male; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Pressoreceptors; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice.
Topics: Analgesia; Animals; beta-Endorphin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Somatostatin | 1990 |
Identification of the opioid receptor types mediating beta-endorphin-induced alterations in dopamine release in the nucleus accumbens.
Topics: Analgesics; Animals; beta-Endorphin; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Somatostatin | 1990 |
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan | 1990 |
ICI 174,864, a selective delta opioid antagonist, reverses the learning impairment produced by [leu]enkephalin.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Electroshock; Enkephalin, Leucine; Learning; Male; Mice; Motor Activity; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Modulation of the analgesic efficacy and potency of morphine by [D-Pen2, D-Pen5]enkephalin in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions.
Topics: Animals; Bradykinin; Cations, Monovalent; Cell Line; Cell Membrane; Cell-Free System; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; In Vitro Techniques; Ligands; Magnesium; Pertussis Toxin; Receptors, Opioid; Signal Transduction; Sodium; Virulence Factors, Bordetella | 1990 |
Chronic blockade of D2 but not D1 dopamine receptors facilitates behavioural responses to endogenous enkephalins, protected by kelatorphan, administered in the accumbens in rats.
Topics: Animals; Behavior, Animal; Benzazepines; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalins; Haloperidol; Injections; Male; Motor Activity; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Sulpiride | 1990 |
Delta but not mu-opioid receptors in the spinal cord are involved in antinociception induced by beta-endorphin given intracerebroventricularly in mice.
Topics: Analgesia; Animals; beta-Endorphin; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Role of peripheral mu, delta and kappa opioid receptors in opioid-induced inhibition of gastrointestinal transit in rats.
Topics: Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; Male; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
A lack of potency for the delta-opioid antagonist naltrindole after microinjection into the rostral ventrolateral medulla of rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Indoles; Male; Medulla Oblongata; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological | 1990 |
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective delta agonist in vivo.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Opioid regulation of mucosal ion transport in the mouse isolated jejunum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Biological Transport; Chlorides; Electrolytes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Intestinal Mucosa; Jejunum; Mice; Morphine; Pyrrolidines; Sodium | 1990 |
Modulation of morphine antinociception by peripheral [Leu5]enkephalin: a synergistic interaction.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists | 1990 |
Inhibition of exocrine pancreatic secretion by opiates is mediated by suppression of cholinergic transmission: characterization of receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Amylases; Animals; Cholinergic Fibers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Narcotics; Pancreas; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptic Transmission | 1988 |
Mu and delta opioid receptors inhibit serotonin release in rat hippocampus.
Topics: Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Hippocampus; In Vitro Techniques; Male; Pertussis Toxin; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin; Virulence Factors, Bordetella | 1989 |
Activation of central mu-opioid receptors is involved in clonidine analgesia in rats.
Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Male; Naloxone; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Species Specificity | 1989 |
Influence of opioid peptides on learning and memory processes in the chick.
Topics: Animals; Attention; beta-Endorphin; Brain Mapping; Chickens; Discrimination Learning; Dominance, Cerebral; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Memory; Mental Recall; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Visual Cortex | 1989 |
Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Male; Morphine; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Effects of selective opioid-receptor blockade on the hypothalamo-pituitary-adrenocortical responses to surgical trauma in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological | 1989 |
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
Topics: Animals; Benzomorphans; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Narcotic Antagonists; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1989 |
mu-Opioid peptide modulation of cardiovascular and sympathoadrenal responses to stress.
Topics: Animals; Blood Pressure; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Restraint, Physical; Stress, Psychological; Time Factors | 1989 |
Delta-opioid mediated inhibitions of acute and prolonged noxious-evoked responses in rat dorsal horn neurones.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Evoked Potentials; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Sympathoadrenal, cardiovascular and blood gas responses to highly selective mu and delta opioid peptides.
Topics: Animals; Blood Pressure; Carbon Dioxide; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Male; Naloxone; Oxygen; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
[Effects of intrahippocampal delta-receptors on inhibition of electroconvulsive shock by electro-acupuncture].
Topics: Animals; Electroacupuncture; Electroshock; Enkephalin, Leucine; Female; Hippocampus; Male; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
Differential modulation by [D-Pen2, D-Pen5]enkephalin and dynorphin A-(1-17) of the inhibitory bladder motility effects of selected mu agonists in vivo.
Topics: Analgesics; Animals; Drug Synergism; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Morphine; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Urinary Bladder | 1989 |
Lack of mixed agonist-antagonist properties of [Gln8-Gly31]-beta h-EP-Gly-Gly-NH2 and [Arg9,19,24,28,29]-beta h-EP in the rat vas deferens neuroeffector junction: studies with naloxone, beta-funaltrexamine and ICI 174,864.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neuroeffector Junction; Rats; Rats, Inbred Strains; Vas Deferens | 1989 |
Evidence that the aversive effects of opioid antagonists and kappa-agonists are centrally mediated.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Conditioning, Operant; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin | 1989 |
Presynaptic auto- and allelo-receptor regulation of hypothalamic opioid peptide release.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Narcotic Antagonists; Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Sulfhydryl Reagents | 1989 |
Swim-stress-induced antinociception in young rats.
Topics: Aging; Animals; Animals, Newborn; Enkephalin, Leucine; Female; Male; Naloxone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Stress, Psychological; Swimming | 1989 |
Kelatorphan, a potent enkephalinases inhibitor, and opioid receptor agonists DAGO and DTLET, differentially modulate self-stimulation behaviour depending on the site of administration.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Dipeptides; Electrodes, Implanted; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Injections; Injections, Intraventricular; Male; Neprilysin; Nucleus Accumbens; Oligopeptides; Rats; Rats, Inbred Strains; Self Stimulation | 1989 |
Presynaptic opioid receptors in the portal vein of the rabbit.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Naloxone; Narcotic Antagonists; Narcotics; Portal Vein; Rabbits; Receptors, Opioid | 1987 |
Characterization of rabbit ear artery opioid receptors using a delta-selective agonist and antagonist.
Topics: Animals; Arteries; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Muscle, Smooth; Muscle, Smooth, Vascular; Naloxone; Narcotic Antagonists; Rabbits; Rats; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1987 |
Involvement of opiate receptor subtypes in the modulation of LHRH secretion by the cockerel (Gallus domesticus) mediobasal hypothalamus in vitro.
Topics: Animals; Benzodiazepines; Chickens; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Naloxone; Oligopeptides; Receptors, Opioid | 1987 |
[Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon.
Topics: Animals; Cats; Colon; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1987 |
Delta-opioid receptors mediate inhibition of fast excitatory postsynaptic potentials in cat parasympathetic colonic ganglia.
Topics: Animals; Cats; Colon; Enkephalin, Leucine; Evoked Potentials; Female; Ganglia, Parasympathetic; In Vitro Techniques; Male; Membrane Potentials; Motor Endplate; Naloxone; Narcotic Antagonists; Receptors, Nicotinic; Receptors, Opioid; Receptors, Opioid, delta; Synapses | 1987 |
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1987 |
The effect of neurotensin, TRH and the delta-opioid receptor antagonist ICI 174864 on alcohol-induced narcosis in rats.
Topics: Animals; Body Temperature; Central Nervous System Diseases; Enkephalin, Leucine; Ethanol; Male; Neurotensin; Rats; Rats, Inbred Strains; Receptors, Opioid; Rectum; Sleep; Thyrotropin-Releasing Hormone; Time Factors | 1987 |
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
Topics: Animals; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Hyperalgesia produced by intrathecal opioid antagonists depends on receptor selectivity and noxious stimulus.
Topics: Analgesia; Animals; Benzomorphans; Enkephalin, Leucine; Hyperalgesia; Hyperesthesia; Injections, Spinal; Male; Morphinans; Naloxone; Narcotic Antagonists; Pain; Rats; Receptors, Opioid | 1986 |
The role of mu- and delta- opioid receptors on the intestinal propulsion in rats.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Gastrointestinal Transit; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Motivational properties of opioids: evidence that an activation of delta-receptors mediates reinforcement processes.
Topics: Animals; Appetitive Behavior; Avoidance Learning; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Morphine; Motivation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Reinforcement, Psychology | 1987 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
Selective effects of beta-endorphin infused into the hypothalamus, preoptic area and bed nucleus of the stria terminalis on the sexual and ingestive behaviour of male rats.
Topics: Animals; beta-Endorphin; Cholecystokinin; Enkephalin, Leucine; Feeding Behavior; Hypothalamus, Anterior; Male; Naloxone; Preoptic Area; Rats; Reaction Time; Receptors, Opioid; Sexual Behavior, Animal; Thiazines | 1987 |
Opioid antinociceptive effects of delta-receptor antagonists.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalin, Leucine; Male; Mice; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Opioid receptor selectivity of beta-endorphin in vitro and in vivo: mu, delta and epsilon receptors.
Topics: Analgesia; Animals; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Gastric Emptying; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1988 |
Enkephalins modulate in vivo immune reactions through delta- and mu-opioid receptors.
Topics: Animals; Antibody Formation; Enkephalin, Leucine; Enkephalins; Mice; Mice, Inbred BALB C; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Involvement of Mu receptors in the opioid-induced increase in the turnover of mouse brain histamine.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Histamine; Male; Methylhistamines; Methylhistidines; Mice; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu; Tetrodotoxin | 1988 |
Conversion of dynorphin-(1-9) to [Leu5]enkephalin by the mouse vas deferens in vitro.
Topics: Animals; Benzomorphans; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Muscle, Smooth; Narcotic Antagonists; Peptide Fragments; Vas Deferens | 1985 |
Presynaptic opioid receptors modulating acetylcholine release in the hippocampus of the rabbit.
Topics: Acetylcholine; Animals; Benzomorphans; Choline; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Naloxone; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hypercapnia; Hypoxia; Peptide Fragments; Receptors, Opioid | 1986 |
Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217.
Topics: Analgesics, Opioid; Animals; Carboxypeptidases; Carboxypeptidases A; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1986 |
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Hindlimb; Injections, Spinal; Male; Motor Activity; Nociceptors; Paralysis; Peptide Fragments; Rats; Rats, Inbred Strains; Spinal Cord | 1988 |
Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats.
Topics: Animals; Cats; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Narcotic Antagonists; Narcotics; Peptide Fragments; Stomach; Vagus Nerve | 1988 |
Neurologic deficits and neuronal injury in rats resulting from nonopioid actions of the delta opioid receptor antagonist ICI 174864.
Topics: Animals; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Male; Narcotic Antagonists; Neurons; Paralysis; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1988 |
Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure.
Topics: Animals; Anticonvulsants; Electroshock; Enkephalin, Leucine; Male; Naloxone; Narcotic Antagonists; Peptide Hydrolases; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures | 1985 |
Studies in vivo with ICI 174864 and [D-Pen2, D-Pen5]enkephalin.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Gastrointestinal Motility; Male; Mice; Motor Activity; Posture; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Studies in vitro with ICI 174,864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO).
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
Central delta-opioid receptor interactions and the inhibition of reflex urinary bladder contractions in the rat.
Topics: Animals; beta-Endorphin; Central Nervous System; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalins; Female; Injections, Intraventricular; Injections, Spinal; Muscle Contraction; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1985 |
Neurohypophysial opioids and oxytocin secretion: source of inhibitory opioids.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalin, Leucine; Female; Lactation; Naloxone; Neural Inhibition; Oxytocin; Pituitary Gland, Posterior; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, delta; Supraoptic Nucleus | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
Proenkephalin A fragments exhibit spinal and supraspinal opioid activity in vivo.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Muscle Contraction; Naloxone; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Urinary Bladder | 1985 |
Characterisation of the delta-opioid receptor on the hamster vas deferens.
Topics: Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Mesocricetus; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1985 |
Centrally administered beta-endorphin produces prolonged changes in delta-opioid ligand activity in vivo.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Intraventricular; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1986 |
Classification of presynaptic opioid receptors in the rabbit ear artery by competitive antagonists.
Topics: Animals; Arteries; Benzomorphans; Binding, Competitive; Biological Assay; Cyclazocine; Ear; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Naloxone; Rabbits; Receptors, Opioid; Synaptic Membranes | 1986 |
Blockade of D-2 dopamine receptors strongly enhances the potency of enkephalins to inhibit dopamine-sensitive adenylate cyclase in rat neostriatum: involvement of delta- and mu-opioid receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclase Inhibitors; Animals; Benzazepines; Corpus Striatum; Cyclic AMP; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ergolines; Male; Morphine; Naloxone; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
In vivo binding of putative delta-selective opioid antagonists to central opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Thebaine | 1986 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Evidence that endogenous enkephalins produce delta-opiate receptor mediated neuronal inhibitions in rat dorsal horn.
Topics: Animals; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Nerve Fibers; Neural Inhibition; Rats; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1986 |
Audiogenic seizures during ethanol withdrawal can be blocked by a delta opioid agonist.
Topics: Acoustic Stimulation; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethanol; Female; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome | 1986 |
Delta receptors in the rat vas deferens.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1986 |
Proglumide exhibits delta opioid agonist properties.
Topics: Animals; Binding, Competitive; Electric Stimulation; Enkephalin, Leucine; Enzyme Inhibitors; Glutamine; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naloxone; Norepinephrine; Proglumide; Receptors, Opioid; Receptors, Opioid, delta; Synaptosomes | 1987 |
Inhibition of dopamine-sensitive adenylate cyclase by opioids: possible involvement of physically associated mu- and delta-opioid receptors.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Corpus Striatum; Cyclic AMP; Dopamine Antagonists; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Isoproterenol; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vasoactive Intestinal Peptide | 1987 |
Actions of opioids on the dorsal root potential of the isolated spinal cord preparation of the neonate rat.
Topics: Animals; Animals, Newborn; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Spinal Nerve Roots | 1987 |
The contributions of mu-, delta- and kappa-opioid receptors to the actions of endogenous opioids on spinal reflexes in the rabbit.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalin, Leucine; Hemodynamics; Naloxone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1987 |
The effects of selective opioid delta-receptor antagonists on stress-induced antinociception and plasma corticosterone levels in mice.
Topics: Analgesia; Animals; Enkephalin, Leucine; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pituitary-Adrenal System; Stress, Physiological | 1985 |
Hyperphagia induced by 2-deoxy-D-glucose in the presence of the delta-opioid antagonist ICI 174,864.
Topics: Animals; Deoxy Sugars; Deoxyglucose; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding and Eating Disorders; Hyperphagia; Male; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1985 |
Radioligands for probing opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1984 |
Inhibition via opioid mu- and delta-receptors of vagal transmission in rabbit isolated heart.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; In Vitro Techniques; Male; Morphine; Naloxone; Parasympathetic Nervous System; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptic Transmission; Vagus Nerve | 1984 |
Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1984 |
Hamster vas deferens contains delta-opioid receptors.
Topics: Animals; Cricetinae; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Male; Mesocricetus; Naloxone; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1984 |
ICI 174864, a putative delta opioid antagonist, reverses endotoxemic hypotension: pretreatment with dynorphin 1-13, A kappa agonist, blocks this action.
Topics: Animals; Blood Pressure; Dynorphins; Enkephalin, Leucine; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Shock, Septic | 1984 |
ICI 174864: a highly selective antagonist for the opioid delta-receptor.
Topics: Animals; Enkephalin, Leucine; Male; Mice; Muscle Contraction; Naloxone; Receptors, Opioid; Vas Deferens | 1984 |
Electrophysiological demonstration and activation of mu-opioid receptors in the rabbit sinoatrial node.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Fentanyl; Microelectrodes; Naltrexone; Narcotic Antagonists; Narcotics; Patch-Clamp Techniques; Rabbits; Receptors, Opioid, mu; Sinoatrial Node | 1995 |
Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Glycosylation; Molecular Sequence Data; Naltrexone; Oligopeptides; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sodium; Tritium | 1995 |
Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine.
Topics: Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Ketorolac Tromethamine; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tolmetin; Tromethamine | 1995 |
[Contribution of dopamine autoreceptors in the reactive effect of opioid antagonists].
Topics: Animals; Avoidance Learning; Dopamine Agonists; Enkephalin, Leucine; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Piperidines; Receptors, Dopamine; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Opposing activities of brain opioid receptors in the regulation of humoral and cell-mediated immune responses in the rat.
Topics: Analysis of Variance; Animals; Antibody Formation; Benzomorphans; Brain; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Hypersensitivity, Delayed; Immunity, Cellular; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Skin | 1994 |
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin | 1994 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Gx/z and Gi2 transducer proteins on mu/delta opioid-mediated supraspinal antinociception.
Topics: Amino Acid Sequence; Analgesics, Opioid; Analysis of Variance; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Immune Sera; Male; Mice; Molecular Sequence Data; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
The mechanism involved in the central effect of 5-leu enkephalin on the calcitonin secretion.
Topics: Animals; Calcitonin; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Naloxone; Narcotic Antagonists; Oxidopamine; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Sympathectomy, Chemical; Thyroid Gland | 1993 |
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
Topics: Analysis of Variance; Animals; Antibodies; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclosporine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Inflammation; Injections; Interleukin-1; Male; Naloxone; Pain; Rats; Rats, Wistar; Recombinant Proteins; Regression Analysis; Somatostatin | 1994 |
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
Topics: Animals; Benzimidazoles; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, mu; Spinal Cord | 1994 |
Differential regulation of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells.
Topics: Amino Acid Sequence; Cell Differentiation; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
Lack of involvement of delta-opioid receptor in mediating physical dependence at the hypothalamus-pituitary-adrenocortical (HPA) axis in the rat.
Topics: Animals; Corticosterone; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Opioid-Related Disorders; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
Effects of opioid receptors antagonists administration to suprachiasmatic nucleus on hibernation of ground squirrels Citellus dauricus.
Topics: Animals; Endorphins; Enkephalin, Leucine; Female; Hibernation; Injections; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sciuridae; Suprachiasmatic Nucleus | 1993 |
Opioid actions on neurons of rat lateral amygdala in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Amino Acids; Amygdala; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; GABA-A Receptor Antagonists; In Vitro Techniques; Molecular Sequence Data; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pyrrolidines; Rats; Somatostatin; Synapses | 1993 |
Involvement of mu-opioid receptors in alcohol drinking by alcohol-preferring AA rats.
Topics: Alcohol Drinking; Amino Acid Sequence; Animals; Body Weight; Drinking Behavior; Eating; Enkephalin, Leucine; Feeding Behavior; Female; Injections, Intraventricular; Male; Molecular Sequence Data; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu; Sex Characteristics; Somatostatin | 1993 |
Regulatory role of enteric kappa opioid receptors in human colonic motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Colon, Sigmoid; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Gastrointestinal Motility; Humans; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Immunoglobulin G; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Morphine; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Protein Binding; Reaction Time; Receptors, Opioid, delta | 1994 |
The decompensatory phase of acute hypovolaemia in rabbits involves a central delta 1-opioid receptor.
Topics: Animals; Benzylidene Compounds; Blood Pressure; Cardiac Output; Enkephalin, Leucine; Hemodynamics; Hemorrhage; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Shock | 1994 |
[The participation of the delta opioid receptors in immunomodulation].
Topics: Animals; Cyproheptadine; Enkephalin, Leucine; Haloperidol; Immunization; Male; Mice; Mice, Inbred CBA; Narcotic Antagonists; Neuroimmunomodulation; Pituitary Gland; Receptors, Opioid, delta; Thymus Gland | 1993 |
Multiple opioid system involvement in the mediation of parasitic-infection induced analgesia.
Topics: Analgesia; Animals; Coccidiosis; Endorphins; Enkephalin, Leucine; Host-Parasite Interactions; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists | 1993 |
Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination Learning; Enkephalin, Leucine; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Arousal following intra-preoptic area administration of naltrexone, ICI 174864 or nor-BNI in hibernating ground squirrels.
Topics: Animals; Arousal; Brain Mapping; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Hibernation; Male; Naltrexone; Narcotic Antagonists; Preoptic Area; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciuridae | 1993 |
Sex differences in the antinociceptive effects of the enkephalinase inhibitor, SCH 34826.
Topics: Analgesia; Analgesics; Animals; Dioxolanes; Dipeptides; Enkephalin, Leucine; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Peromyscus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Sex Characteristics; Stress, Psychological | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1993 |
Effect of delta-opioid antagonists on the functional coupling between opioid receptors and G-proteins in rat brain membranes.
Topics: Adenylate Cyclase Toxin; Amino Acid Sequence; Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Membranes; Molecular Sequence Data; Oligopeptides; Pertussis Toxin; Rats; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1993 |
Effect of Met-enkephalin and opioid antagonists on rat macrophages.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hydrogen Peroxide; Infant, Newborn; Macrophages; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1995 |
Memory retrieval enhancement by kappa opioid agonist and mu, delta antagonists.
Topics: Analysis of Variance; Animals; Dynorphins; Enkephalin, Leucine; Male; Memory; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Analysis of inverse agonism at the delta opioid receptor after expression in Rat 1 fibroblasts.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA, Complementary; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Proteins; Mice; Molecular Sequence Data; Narcotic Antagonists; Pertussis Toxin; Rats; Receptors, Opioid, delta; Sensitivity and Specificity; Transfection; Virulence Factors, Bordetella | 1996 |
The effects of delta-opioid receptor agonists on synaptic transmission in hamster submandibular ganglion.
Topics: Animals; Autonomic Fibers, Preganglionic; Cricetinae; Dimethylphenylpiperazinium Iodide; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; Ganglionic Stimulants; Naloxone; Narcotic Antagonists; Presynaptic Terminals; Receptors, Opioid, delta; Submandibular Gland; Synaptic Transmission | 1995 |
Involvement of beta-endorphin in the modulation of paw inflammatory edema in the rat.
Topics: Animals; Antibodies; Benzomorphans; beta-Endorphin; Edema; Enkephalin, Leucine; Foot; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Yeasts | 1996 |
Dopamine and opioid regulation of the memory retrieval recovery in mice.
Topics: Animals; Avoidance Learning; Dopamine Agonists; Enkephalin, Leucine; Male; Memory; Mice; Mice, Inbred BALB C; Narcotic Antagonists; Piperidines; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid, delta | 1996 |
Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1996 |
Modulation of humoral immune response by central administration of leucine-enkephalin: effects of mu, delta and kappa opioid receptor antagonists.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antibody-Producing Cells; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hemolytic Plaque Technique; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation.
Topics: Cell Line; Colforsin; Cyclic AMP; Drug Interactions; Enkephalin, Leucine; Humans; Narcotic Antagonists; Receptors, Opioid, delta | 1996 |
The importance of delta and kappa opioid receptors in the property of thyrotropin-releasing hormone against hemorrhagic shock.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Female; Heart Rate; Hemodynamics; Kinetics; Male; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Shock, Hemorrhagic; Thyrotropin-Releasing Hormone | 1997 |
Regulation of spontaneous activity of the delta-opioid receptor: studies of inverse agonism in intact cells.
Topics: Adenine; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cholera Toxin; Clone Cells; Colforsin; Cyclic AMP; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Mice; Naloxone; Narcotic Antagonists; Pertussis Toxin; Rats; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1997 |
Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects.
Topics: Animals; Benzylidene Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Sodium | 1997 |
[The use of central administration of the delta1- and delta2-opiate receptor agonists for prevention of the experimental adrenal arrhythmias].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Epinephrine; Injections, Intraventricular; Male; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Vagus Nerve | 1997 |
In vivo assessment of opioid agonists and antagonists on ovarian maturation in the red swamp crayfish, Procambarus clarkii.
Topics: Animals; Astacoidea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Naloxone; Narcotic Antagonists; Ovary; Receptors, Opioid, delta | 1996 |
In vitro exposure to peptidic delta opioid receptor antagonists results in limited immunosuppression.
Topics: Animals; B-Lymphocytes; Cell Division; Enkephalin, Leucine; Female; Immune Tolerance; Interleukin-2; Interleukin-6; Killer Cells, Natural; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; T-Lymphocytes; Tetrahydroisoquinolines | 1997 |
Modulation of volitional ethanol intake in the rat by central delta-opioid receptors.
Topics: Alcohol Drinking; Animals; Enkephalin, Leucine; Male; Naloxone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1998 |
Receptor-activated Ca2+ increases in vibrodissociated cortical astrocytes: a nonenzymatic method for acute isolation of astrocytes.
Topics: Animals; Astrocytes; Calcium; Cell Separation; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glutamic Acid; Immunohistochemistry; Indans; Norepinephrine; Phenylephrine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Serotonin | 1998 |
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus | 1999 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
[Opiatergic mechanisms of cardioprotective and anti-arrhythmic effects of adaptation].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, Leucine; Epinephrine; Heart; Hypoxia; Immobilization; Male; Naltrexone; Narcotic Antagonists; Plant Extracts; Rats; Rats, Wistar | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
Activation of spinal opioid receptors contributes to hypotension after hemorrhage in conscious rats.
Topics: Animals; Blood Pressure; Consciousness; Dynorphins; Endorphins; Enkephalin, Leucine; Heart Rate; Hemorrhage; Hypotension; Male; Naloxone; Narcotic Antagonists; Neural Inhibition; Rats; Rats, Inbred WKY; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Sympathetic Nervous System | 1999 |
(2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor.
Topics: Animals; CHO Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Membranes; Protein Binding; Receptors, Opioid, delta; Sulfur Radioisotopes; Tetrahydroisoquinolines; Tyrosine | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Analgesic effect of interferon-alpha via mu opioid receptor in the rat.
Topics: Analgesia; Animals; Antibodies, Monoclonal; Cell Line; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Injections, Intraventricular; Interferon Type I; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Proteins | 2000 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
Topics: Age Factors; Amnesia; Analgesics, Opioid; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Chickens; Chloramphenicol; Conditioning, Psychological; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Female; Male; Memory; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Protein Synthesis Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 2000 |
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans.
Topics: Acids; Analgesics; Analgesics, Opioid; Animals; Cell Differentiation; CHO Cells; Cricetinae; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Fentanyl; Humans; Naloxone; Narcotic Antagonists; Neuroblastoma; Neurons; Tumor Cells, Cultured | 2001 |
Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human delta -opioid receptor displays constitutive oligomerization at the cell surface, which is not regulate
Topics: Blotting, Western; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalins; Epitopes; Humans; Immunoblotting; Ligands; Luminescent Measurements; Narcotic Antagonists; Plasmids; Precipitin Tests; Protein Binding; Receptors, Adrenergic, beta-2; Receptors, Opioid, delta; Signal Transduction; Spectrometry, Fluorescence; Time Factors; Transfection | 2001 |
Stimulation of mu and delta-Opiate Receptors and Tolerance of Isolated Heart to Oxidative Stress: the Role of NO-Synthase.
Topics: Animals; Creatine Kinase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; In Vitro Techniques; Injections, Intravenous; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Perfusion; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Superoxide Dismutase | 2001 |
[The role of mu- and delta-opiate receptors in resistance of the myocardium to free radical damage].
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Free Radicals; In Vitro Techniques; Lipid Peroxidation; Myocardial Contraction; Myocardium; Oligopeptides; Oxidative Stress; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2001 |
Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.
Topics: Animals; Autonomic Nervous System; Cats; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gallbladder; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Neural Inhibition; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 2001 |
Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation.
Topics: Biotransformation; Cell Line; Cell Membrane; Enkephalin, Leucine; Flow Cytometry; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Narcotic Antagonists; Pertussis Toxin; Receptors, Opioid, delta; Signal Transduction; Virulence Factors, Bordetella | 2001 |
Short-term inverse-agonist treatment induces reciprocal changes in delta-opioid agonist and inverse-agonist binding capacity.
Topics: Analgesics; Benzomorphans; Binding Sites; Cells, Cultured; Cyclic AMP; Enkephalin, Leucine; Humans; Narcotic Antagonists; Protein Conformation; Radioligand Assay; Receptors, Opioid, delta; Tritium | 2001 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
[The postburn change in hypothalamic paraventricular beta-endorphin and the roles of delta-receptor in scalded rats].
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Blood Pressure; Burns; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Heart Rate; Male; Narcotic Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Survival Analysis | 2002 |
Effect of in vivo and in vitro stimulation of delta1-opioid receptors on myocardial resistance to arrhythmogenic action of ischemia and reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta | 2002 |
Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Decanoic Acids; Disease Models, Animal; Drug Antagonism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Hydroxy Acids; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Naloxone; Potassium Channels; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, delta; Sclerosis; Ventricular Fibrillation | 2003 |
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
Topics: Alkaline Phosphatase; Benzamides; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mutation; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Structure-Activity Relationship | 2005 |
Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands.
Topics: Blotting, Western; Cell Line; Cyclic AMP; DNA; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Endocytosis; Enkephalin, Leucine; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Genetic Vectors; Humans; Immunoprecipitation; Kinetics; Ligands; Narcotic Antagonists; Oligopeptides; Phosphorylation; Receptors, Opioid, delta; Signal Transduction; Sucrose; Tetrahydroisoquinolines; Time Factors; Transfection | 2005 |
[Changes in systemic and local vascular reactivity in hemorrhagic shock and the therapeutic effect of delta opioid receptor antagonist ICI174,864].
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Male; Mesenteric Artery, Superior; Norepinephrine; Random Allocation; Rats; Rats, Wistar; Receptors, Opioid, delta; Shock, Hemorrhagic; Vasoconstriction | 2005 |
Delta-opioid receptor antagonists exhibit properties of partial delta-receptor agonists in isolated perfused heart.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Naltrexone; Oligopeptides; Perfusion; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta | 2004 |
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; gamma-Aminobutyric Acid; Glycine Agents; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotic Antagonists; Narcotics; Neurons; Oligopeptides; Patch-Clamp Techniques; Periaqueductal Gray; Protein Kinase Inhibitors; Receptors, Opioid, delta; Receptors, Opioid, mu; Strychnine; Sulfonamides; Synaptic Transmission; Time Factors; Xanthines | 2005 |
delta-opioid receptor-mediated actions on rostral ventromedial medulla neurons.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Calcium Channels; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; In Vitro Techniques; Lysine; Male; Medulla Oblongata; Membrane Potentials; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Serotonin; Substance P; Tryptophan Hydroxylase | 2005 |
Subclass opioid receptors associated with the cardiovascular depression after traumatic shock and the antishock effects of its specific receptor antagonists.
Topics: Animals; Blood Pressure; Cardiovascular System; Enkephalin, Leucine; Femur; Free Radicals; GABA Modulators; Hemodynamics; Models, Statistical; Naltrexone; Narcotic Antagonists; Pentobarbital; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Shock; Time Factors | 2005 |
Modulation of cardiovascular excitatory responses in rats by transcutaneous magnetic stimulation: role of the spinal cord.
Topics: Afferent Pathways; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Electroacupuncture; Enkephalin, Leucine; Magnetics; Male; Median Nerve; Naloxone; Neurotransmitter Agents; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Spinal Cord; Stomach; Sympathetic Nervous System | 2006 |
Presynaptic delta opioid receptors regulate ethanol actions in central amygdala.
Topics: Amygdala; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ethanol; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Receptors, Opioid, delta | 2007 |
Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.
Topics: Animals; Cell Line, Tumor; Enkephalin, Leucine; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Molecular Conformation; Phenylalanine; Quantitative Structure-Activity Relationship; Rats; Receptors, Opioid, delta | 2007 |
Central inhibition of opioid receptor subtypes and its effect on haemorrhagic hypotension in conscious sheep.
Topics: Animals; Bradycardia; Enkephalin, Leucine; Hemorrhage; Hypotension; Injections, Intraventricular; Models, Animal; Naltrexone; Narcotic Antagonists; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regional Blood Flow; Renal Circulation; Sheep | 2007 |
Opioid and progesterone signaling is obligatory for early human embryogenesis.
Topics: Analgesics, Opioid; Animals; Cell Differentiation; Cell Line; Embryo, Mammalian; Embryonic Development; Enkephalin, Leucine; Humans; Mice; Mifepristone; Neural Plate; Progesterone; Signal Transduction; Stem Cells | 2009 |
Central administration of somatostatin stimulates feeding behavior in chicks.
Topics: Alkylating Agents; Animals; Animals, Newborn; Chickens; Eating; Enkephalin, Leucine; Hormones; Male; Naltrexone; Narcotic Antagonists; Neuropeptides; Receptors, Opioid; Somatostatin | 2009 |
Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward.
Topics: Amygdala; Animals; Conditioning, Operant; Drive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Food; Guanidines; Male; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Somatostatin; Sucrose | 2011 |
δ opioid receptor antagonists: do they buy time for traumatic hemorrhagic shock patients?
Topics: Animals; Enkephalin, Leucine; Narcotic Antagonists; Receptors, Opioid, delta; Shock, Hemorrhagic | 2013 |
δ opioid receptor antagonist, ICI 174,864, is suitable for the early treatment of uncontrolled hemorrhagic shock in rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Leucine; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Shock, Hemorrhagic; Survival Analysis | 2013 |
Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.
Topics: Drug Inverse Agonism; Enkephalin, Leucine; Halogenation; Humans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Recombinant Proteins | 2015 |