enkephalin, leucine has been researched along with morphinans in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (38.46) | 18.7374 |
| 1990's | 52 (57.14) | 18.2507 |
| 2000's | 2 (2.20) | 29.6817 |
| 2010's | 2 (2.20) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keane, PE; Neal, H | 1 |
| Clarke, FH; Jaggi, H; Lovell, RA | 1 |
| Champagnat, J; Denavit-Saubié, M; Zieglgänsberger, W | 1 |
| Makman, MH; Walczak, SA; Wilkening, D | 1 |
| Akera, T; Brody, TM; Davis, ME | 1 |
| Arrigo-Reina, R; Ferri, S; Santagostino, A; Scoto, GM; Spadaro, C | 1 |
| Berggren, A; Rubenson, A; Sillén, U | 1 |
| Costa, EM; Hoffmann, BB; Loew, GH | 1 |
| Bowen, WD; Farmer, SC; Mattia, A; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Akami, T; Arakawa, K; Matsumoto, S; Mitsuo, M; Nagase, H; Nakai, I; Nakajima, H; Oka, T; Okamoto, M | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Kane, K; McIntosh, M; Parratt, J | 1 |
| Giles, A; Landymore, KM; Wilkinson, M | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 2 |
| Cheng, PY; Cheng, Y; Decena, J; McCabe, S; Szeto, HH; Wu, DL | 1 |
| De Vries, TJ; Hogenboom, F; Hruby, VJ; Mulder, AH; Portoghese, PS; Schoffelmeer, AN | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Crook, TJ; Hill, RG; Kitchen, I | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 1 |
| Adler, MW; Geller, EB; Handler, CM | 1 |
| Archer, S; Emmerson, PJ; Medzihradsky, F; Seyed-Mozaffari, A | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Bowen, WD; Jiang, Q; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Portoghese, PS | 1 |
| Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP | 1 |
| Abdelhamid, EE; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Kaneto, H; Kawasaki, K; Kobayashi, Y; Maeda, M; Shimokawa, K; Taguchi, T; Takahashi, M; Tokuyama, S; Watanabe, J; Yamamoto, Y | 1 |
| de Costa, BR; Drower, EJ; Hammond, DL; Rafferty, MF; Rice, KC; Stapelfeld, A | 1 |
| Burks, TF; Davis, TP; Greene, DL; Hersh, LB; Hruby, VJ; Kramer, TH; Sharma, SD; Weber, SJ; Yamamura, HI | 1 |
| Freye, E; Schenk, G; Schnitzler, M | 1 |
| Baamonde, A; Daugé, V; Gacel, G; Roques, BP | 1 |
| Benyhe, S; Borsodi, A; Varga, E; Wollemann, M | 1 |
| Lawrence, AJ; Traynor, JR | 1 |
| Birch, PJ; Hayes, AG; Lawrence, AJ; Rogers, H; Traynor, JR | 1 |
| Calcagnetti, DJ; Holtzman, SG | 1 |
| Froimowitz, M | 1 |
| Berzetei-Gurske, I; Loew, GH | 1 |
| Biswas, R; Maneckjee, R; Vonderhaar, BK | 1 |
| Baumann, NA; Cabon, F; Cupo, A; Ruiz-Gayo, M; Zalc, B | 1 |
| Klein, P; Nelson, WL; Simon, EJ; Yao, YH | 1 |
| Mosberg, HI; Porreca, F; Qi, JN | 1 |
| Chalmers, J; Drolet, G; Morilak, D | 1 |
| Ayres, EA; Burks, TF; Davis, P | 1 |
| Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ | 1 |
| Ayres, EA; Burks, TF; Kramer, TH; Lemcke, PK | 1 |
| Kamikubo, K; Miura, K; Murase, H; Murayama, M; Tsurumi, K; Yasuda, K | 1 |
| Almeida, OF; Herz, A; Pfeiffer, A; Pfeiffer, DG | 1 |
| De Souza, EB; Kuhar, MJ; Schmidt, WK | 1 |
| Browne, JL; Pilcher, CW | 1 |
| Crema, G; Gioannini, TL; Hiller, JM; Simon, EJ | 1 |
| Chang, LR; Law, PY; Loh, HH; Tao, PL | 1 |
| Dougall, IG; Leff, P | 1 |
| De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A | 1 |
| Cruciani, RA; Gainer, H; Lang, MA; Pesce, GO; Rodbard, D; Russell, JT | 1 |
| Ensinger, HA | 1 |
| Greenspan, DL; Musacchio, JM | 1 |
| Herz, A; Morris, BJ | 1 |
| Dunwiddie, TV; Johnson, KJ; Proctor, WR | 1 |
| Schwartz, JP | 1 |
| Bueno, L; Fioramonti, J; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Aktories, K; Costa, T; Jakobs, KH; Wüster, M | 1 |
| Dawson, G; McLawhon, RW; Miller, RJ; West, RE | 1 |
| Blanchard, SG; Chang, KJ; Cuatrecasas, P | 1 |
| Chang, KJ; Cuatrecasas, P; Hazum, E | 2 |
| Gähwiler, BH; Maurer, R | 1 |
| Byrne, WL; Codd, EE | 1 |
| Adler, MW; Cowan, A; Tortella, FC | 1 |
| Catapane, EJ; Kream, RM; Stefano, GB | 1 |
| Faden, AI; Feuerstein, G; Kopin, IJ; Pfeiffer, A | 1 |
| Johnson, N; Pasternak, GW | 1 |
| Gambino, MC; Petrillo, P; Tavani, A | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Bowen, WD; Carlisi, VJ; Hruby, VJ; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Wild, KD | 1 |
| Kameyama, T; Mori, E; Ukai, M | 1 |
| Miyamoto, Y; Portoghese, PS; Takemori, AE | 1 |
| de Costa, BR; Kayakiri, H; Ni, Q; Partilla, JS; Rice, KC; Rothman, RB; Xu, H | 1 |
| Chen, SF; Ghanta, VK; Hiramoto, RN; Hsueh, CM; Huang, HJ | 1 |
| Archer, S; Bidlack, JM; McLaughlin, JP; Sebastian, A | 1 |
| Berkmiller, G; Falk, W; Frauenholz, T; Herrmann, M; Lang, B; Schölmerich, J; Straub, RH | 1 |
| Eckhoff, B; Frenzen, G; Höfner, G; Klindert, T; Seitz, G; Stroetmann, I; Wanner, KT | 1 |
| Bakogeorgou, E; Castanas, E; Damianaki, A; Hatzoglou, A; Kampa, M; Martin, PM | 1 |
| Lomize, AL; Mosberg, HI; Pogozheva, ID | 1 |
| Hata, F; Nishio, H; Nishiwaki, H; Saitoh, N; Takeuchi, T | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| Herzog, H; Loacker, S; Sayyah, M; Schwarzer, C; Wittmann, W | 1 |
| Gaburro, S; Herzog, H; Rosskothen, I; Schunk, E; Schwarzer, C; Singewald, N; Wittmann, W | 1 |
| Balleine, BW; Cely, IC; Maidment, NT; Wassum, KM | 1 |
| Aigner, C; Herzog, H; Schunk, E; Schwarzer, C; Stefanova, N; Wenning, G | 1 |
91 other study(ies) available for enkephalin, leucine and morphinans
| Article | Year |
|---|---|
The effects of local micro injections of opiates and enkephalins into the forebrain on the electrocorticogram of the rat.
Topics: Animals; Brain; Codeine; Electroencephalography; Endorphins; Enkephalins; Etorphine; Male; Morphinans; Morphine; Naloxone; Rats; Receptors, Dopamine; Thebaine | 1978 |
Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin.
Topics: Analgesia; Analgesics; Animals; Brain; Computers; Crystallography; Endorphins; Enkephalins; In Vitro Techniques; Male; Mice; Models, Biological; Models, Molecular; Molecular Conformation; Morphinans; Quinones; Rats; Receptors, Opioid; Structure-Activity Relationship | 1978 |
Effects of opiates and methionine-enkephalin on pontine and bulbar respiratory neurones of the cat.
Topics: Action Potentials; Animals; Cats; Cerebellum; Dextrorphan; Endorphins; Enkephalins; Glutamates; Levorphanol; Morphinans; Morphine; Naloxone; Neurons; Phrenic Nerve; Pons; Receptors, Opioid; Respiration; Respiratory Center | 1978 |
Interaction of morphine, etorphine and enkephalins with dopamine-stimulated adenylate cyclase of monkey amygdala.
Topics: Adenylyl Cyclases; Amygdala; Animals; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Etorphine; Freezing; Haplorhini; Macaca mulatta; Morphinans; Morphine; Naloxone; Receptors, Opioid; Stimulation, Chemical | 1979 |
[D-Alanine2]-methionine enkephalinamide binding to rat brain slices: differences from opiate alkaloid binding and reduction by chronic morphine treatment.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; In Vitro Techniques; Male; Morphinans; Morphine; Naloxone; Rats; Time Factors | 1978 |
[Pharmacological characterization of a pituitary extract with a morphine-like effect].
Topics: Animals; Endorphins; Enkephalins; Female; Guinea Pigs; Ileum; Morphinans; Muscle Contraction; Muscle, Smooth; Pituitary Gland; Rats; Tissue Extracts | 1977 |
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics | 1992 |
Opioid agonists binding and responses in SH-SY5Y cells.
Topics: Alprostadil; Analgesics; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP Phosphohydrolases; Humans; Meperidine; Morphinans; Naloxone; Narcotics; Oxymorphone; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1992 |
Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype.
Topics: Affinity Labels; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Spinal Cord; Thiocyanates | 1992 |
Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.
Topics: Analgesics; beta-Endorphin; Cell Survival; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; Indoles; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Effects of selective opioid receptor agonists and antagonists during myocardial ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Ex vivo determination of opiate antagonist binding at mu-opioid ([3H]-DAGO) receptors in hypothalamic micropunches from maturing female rats: comparison between SDZ 210-096 and nalmefene.
Topics: Age Factors; Animals; Animals, Newborn; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hypothalamus; Morphinans; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation; Vagina | 1992 |
Modulation of kappa-mediated antitussive activity in rats by a delta-agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Cough; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reflex | 1992 |
Central opioid modulation of breathing dynamics in the fetal lamb: effects of [D-Pen2,D-Pen5]-enkephalin and partial antagonism by naltrindole.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetus; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Sheep | 1992 |
Opioid receptor antagonists discriminate between presynaptic mu and delta receptors and the adenylate cyclase-coupled opioid receptor complex in the brain.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
Combination of a delta opioid receptor agonist but not a mu opioid receptor agonist with the D1-selective dopamine receptor agonist SKF 38393 markedly potentiates different behaviors in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Grooming; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Motor Activity; Naltrexone; Sulpiride | 1992 |
Effect of mu-, kappa-, and delta-selective opioid agonists on thermoregulation in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Molecular Sequence Data; Morphinans; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Synthesis and characterization of 7-nitrobenzo-2-oxa-1,3-diazole (NBD)-labeled fluorescent opioids.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Binding Sites; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fluorescent Dyes; Macaca mulatta; Morphinans; Morphine Derivatives; Receptors, Opioid; Sarcosine; Thebaine | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates | 1991 |
An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.
Topics: Amino Acid Sequence; Drug Design; Enkephalins; Indoles; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1991 |
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
Topics: Animals; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Isothiocyanates; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates | 1991 |
The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo.
Topics: Analgesics; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
Topics: Analgesics; Animals; Binding, Competitive; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Neprilysin; Tissue Distribution; Tritium | 1991 |
Opioid-induced respiratory depression and analgesia may be mediated by different subreceptors.
Topics: Analgesia; Animals; Dogs; Enkephalin, Leucine; Evoked Potentials, Somatosensory; Fentanyl; Morphinans; Narcotics; Receptors, Opioid; Respiration | 1991 |
Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
The occurrence of different kappa opioid receptors (K1 and K2) in frog (Rana esculenta) brain membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ligands; Morphinans; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Characterisation of opioid binding sites using selective antagonists.
Topics: Animals; Binding, Competitive; Brain; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Morphinans; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors.
Topics: Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium; Vas Deferens | 1990 |
Delta opioid antagonist, naltrindole, selectively blocks analgesia induced by DPDPE but not DAGO or morphine.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Restraint, Physical; Stress, Psychological | 1991 |
Conformational search in enkephalin analogues containing a disulfide bond.
Topics: Amino Acid Sequence; Disulfides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Models, Molecular; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Thermodynamics | 1990 |
The novel antagonist profile of (-)metazocine.
Topics: Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphinans; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1990 |
Binding of opioids to human MCF-7 breast cancer cells and their effects on growth.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estradiol; Etorphine; Female; Humans; Kinetics; Morphinans; Morphine; Receptors, Opioid; Tumor Cells, Cultured | 1990 |
Pharmacological and molecular properties of opioid binding sites synthesized in a cell-free translation system.
Topics: Animals; Benzomorphans; Binding, Competitive; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hybridomas; Mice; Molecular Weight; Morphinans; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger | 1990 |
Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine.
Topics: Chemical Phenomena; Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Isothiocyanates; Lactones; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Morphinans; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Spectrophotometry, Infrared; Stereoisomerism; Thebaine; Thiocyanates | 1990 |
Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.
Topics: Analgesics; Animals; Codeine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
A lack of potency for the delta-opioid antagonist naltrindole after microinjection into the rostral ventrolateral medulla of rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Indoles; Male; Medulla Oblongata; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1990 |
Delta opioid antagonist, 16-Me cyprenorphine, selectively attenuates conditional fear- and DPDPE-induced analgesia on the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fear; Female; Formaldehyde; Injections, Intraventricular; Morphinans; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
RX809055AX in vivo: a long lasting opioid antagonist at mu and delta receptors.
Topics: Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
[Characterization of adrenal medullary opioid receptors. I. Binding of opioids to adrenal medullary opioid receptors].
Topics: Adrenal Medulla; Animals; Cattle; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; In Vitro Techniques; Metals; Morphinans; Pheochromocytoma; Receptors, Opioid; Tritium | 1987 |
Opiate suppression of LH secretion involves central receptors different from those mediating opiate effects on prolactin secretion.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Luteinizing Hormone; Morphinans; Narcotic Antagonists; Ovariectomy; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic.
Topics: Analgesia; Animals; Autoradiography; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Haplorhini; Male; Morphinans; Nalbuphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1988 |
Hyperalgesia produced by intrathecal opioid antagonists depends on receptor selectivity and noxious stimulus.
Topics: Analgesia; Animals; Benzomorphans; Enkephalin, Leucine; Hyperalgesia; Hyperesthesia; Injections, Spinal; Male; Morphinans; Naloxone; Narcotic Antagonists; Pain; Rats; Receptors, Opioid | 1986 |
The direct demonstration of binding of mu, delta and kappa agonists to digitonin-solubilized opioid receptors from bovine striatum.
Topics: Analgesics; Animals; Benzomorphans; Cattle; Cell Membrane; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Morphinans; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Decrease in delta-opioid receptor density in rat brain after chronic [D-Ala2,D-Leu5]enkephalin treatment.
Topics: Animals; Brain; Diprenorphine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Time Factors | 1988 |
Estimation of opioid receptor agonist dissociation constants with beta-chlornaltrexamine, an irreversible ligand which also displays agonism.
Topics: Animals; Cyclazocine; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Opioid receptors of bovine posterior pituitary neurosecretosomes are exclusively kappa.
Topics: Analgesics, Opioid; Animals; Cattle; Cyclazocine; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Kinetics; Morphinans; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Differentiating aspects of opioid receptor binding by [3H](-) (1R,5R,9R,2''S)-5,9-dimethyl-2-tetrahydrofurfuryl-2'-hydroxy-6,7- benzomorphan hydrochloride ([3H]Mr 2034), a drug preferentially acting on kappa-receptors.
Topics: Animals; Benzomorphans; Binding, Competitive; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1986 |
Autoradiographic localization in rat brain of kappa opiate binding sites labelled by [3H]bremazocine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphinans; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electric Stimulation; Electrodes; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphinans; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Opposite effects of kappa-opioid agonists on gastric emptying of liquids and solids in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Injections, Intravenous; Morphinans; Morphine; Naloxone; Pyrrolidines | 1988 |
Sodium regulation of opioid agonist binding is potentiated by pertussis toxin.
Topics: Animals; Bacterial Toxins; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanine Nucleotides; Hybrid Cells; Mice; Morphinans; Neuroblastoma; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Virulence Factors, Bordetella | 1984 |
Distinct high-affinity binding sites for benzomorphan drugs and enkephalin in a neuroblastoma--brain hybrid cell line.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cell Line; Cyclazocine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hybrid Cells; Kinetics; Morphinans; Neuroblastoma; Phenazocine; Rats; Receptors, Opioid | 1981 |
Benzomorphan sites are ligand recognition sites of putative epsilon-receptors.
Topics: Animals; Benzomorphans; beta-Endorphin; Binding, Competitive; Brain; Cell Membrane; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Guinea Pigs; Humans; Kinetics; Morphinans; Peptide Fragments; Placenta; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Diprenorphine; Endorphins; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Morphinans; Morphine; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Synaptic Membranes | 1980 |
Involvement of mu-receptors in the opioid-induced generation of bursting discharges in hippocampal pyramidal cells.
Topics: Animals; Benzomorphans; Culture Techniques; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Electrophysiology; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Membrane Potentials; Morphinans; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1981 |
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons | 1981 |
Comparison of the anticonvulsant effects of opioid peptides and etorphine in rats after icv administration.
Topics: Animals; Anticonvulsants; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Flurothyl; Male; Morphinans; Naloxone; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1981 |
Novel opiate binding sites selective for benzomorphan drugs.
Topics: Animals; Benzomorphans; Binding, Competitive; Brain; Brain Mapping; Diprenorphine; Endorphins; Enkephalins; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1981 |
Characterization of the dopamine stimulated adenylate cyclase in the pedal ganglia of Mytilus edulis: interactions with etorphine, beta-endorphin, DALA, and methionine enkephalin.
Topics: Adenylyl Cyclases; Animals; beta-Endorphin; Bivalvia; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Ganglia; Kinetics; Morphinans | 1981 |
Cardiovascular and respiratory effects of mu-, delta- and kappa-opiate agonists microinjected into the anterior hypothalamic brain area of awake rats.
Topics: Animals; Anterior Hypothalamic Nucleus; Benzomorphans; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Male; Microinjections; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Wakefulness | 1983 |
The binding to rat brain homogenates of Mr2034, a universal opiate.
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphinans; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats.
Topics: Analgesics; Animals; Benzomorphans; Catatonia; Constipation; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Gastrointestinal Motility; Humans; Male; Morphinans; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens.
Topics: Animals; Benzylidene Compounds; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Thiocyanates; Vas Deferens | 1993 |
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat.
Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Involvement of delta 2 opioid receptors in the development of morphine dependence in mice.
Topics: Animals; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Thiocyanates | 1993 |
Opioid peptide receptor studies. 3. Interaction of opioid peptides and other drugs with four subtypes of the kappa 2 receptor in guinea pig brain.
Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Ligands; Models, Biological; Molecular Sequence Data; Morphinans; Opioid Peptides; Protein Precursors; Rats; Receptors, Opioid, kappa; Swine | 1995 |
Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1996 |
14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists.
Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Cattle; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, mu; Tritium | 1997 |
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analgesics; Animals; beta-Endorphin; Clonidine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Interleukin-6; Isoproterenol; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Narcotic Antagonists; Neurons; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid; Spleen | 1997 |
Syntheses of novel pyridazinomorphinans by inverse electron demand cycloaddition and their binding to mu and kappa receptors.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Cattle; Cell Membrane; Corpus Striatum; Crystallography, X-Ray; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indicators and Reagents; Models, Molecular; Molecular Structure; Morphinans; Pyrazines; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Opioid alkaloids and casomorphin peptides decrease the proliferation of prostatic cancer cell lines (LNCaP, PC3 and DU145) through a partial interaction with opioid receptors.
Topics: Binding Sites; Caseins; Cell Division; Cell Survival; Enkephalins; Ethylketocyclazocine; Humans; Ligands; Male; Morphinans; Narcotic Antagonists; Narcotics; Prostatic Neoplasms; Receptors, Opioid; Tumor Cells, Cultured | 1997 |
Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints.
Topics: Algorithms; Amino Acid Sequence; Benzomorphans; Binding Sites; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Hydrogen Bonding; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; Morphinans; Peptides, Cyclic; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rhodopsin; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity | 1998 |
Relationship between inhibitory effect of endogenous opioid via mu-receptors and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzamides; Cell Count; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Temporal Lobe; Guanidines; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Nerve Degeneration; Piperazines; Protein Precursors; Receptors, Opioid, kappa; Synaptic Transmission; Time Factors | 2007 |
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Brain Stem; Corticosterone; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Exploratory Behavior; Female; Guanidines; Hypothalamus; Male; Maze Learning; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Neuropeptide Y; Neuropeptides; Protein Precursors; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward.
Topics: Amygdala; Animals; Conditioning, Operant; Drive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Food; Guanidines; Male; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Somatostatin; Sucrose | 2011 |
Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; CA1 Region, Hippocampal; Enkephalins; Guanidines; Humans; Interneurons; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Neurodegenerative Diseases; Protein Precursors; Pyramidal Cells; Receptors, Opioid, kappa; Seizures | 2011 |