enkephalin, leucine has been researched along with morphiceptin, n-me-phe(3)- in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (28.85) | 18.7374 |
| 1990's | 36 (69.23) | 18.2507 |
| 2000's | 1 (1.92) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, EM; Hoffmann, BB; Loew, GH | 1 |
| Chavkin, C; Wimpey, TL | 2 |
| Olianas, MC; Onali, P | 1 |
| Adler, MW; Geller, EB; Handler, CM | 1 |
| Golbraikh, AA; Nikiforovich, GV; Shenderovich, MD | 1 |
| Burks, TF; Davis, P; Delaet, N; Kramer, TH; Tourwe, D | 1 |
| Bauer, AJ; Szurszewski, JH | 1 |
| Caudle, RM; Chavkin, C | 1 |
| Han, JS; Wang, XH; Wang, XJ | 1 |
| Han, JS; Wang, XJ; Zhang, LJ | 1 |
| Burks, TF; Lemcke, PK; Shook, JE | 1 |
| Han, JS; Mei, L | 1 |
| Caudle, RM; Chavkin, C; Wagner, JJ | 1 |
| Knapp, RJ; Yamamura, HI | 1 |
| Ayres, EA; Burks, TF; Davis, P | 1 |
| Burks, TF; Gehrig, CA; Hruby, VJ; Lemcke, PK; Shook, JE | 1 |
| Ayres, EA; Burks, TF; Hruby, VJ; Kramer, TH; Lemcke, PK; Toth, G | 1 |
| Ayres, EA; Burks, TF; Kramer, TH; Lemcke, PK | 1 |
| Ayres, EA; Burks, TF; Hruby, VJ; Kazmierski, W; Kramer, TH; Shook, JE; Wire, WS | 1 |
| Burks, TF; Hruby, VJ; Pelton, JT; Shook, JE | 1 |
| Chang, KJ; Leslie, JB; Russell, RD; Su, YF; Watkins, WD | 2 |
| Burks, TF; Fox, DA | 1 |
| Nunan, L; Porreca, F; Sheldon, RJ | 1 |
| Burks, TF; Hruby, VJ; Lemcke, PK; Pelton, JT; Porreca, F; Shook, JE | 1 |
| Chavkin, C; Mailheau, S; Neumaier, JF | 1 |
| Haddad, GG; Schaeffer, JI | 1 |
| Burks, TF; Shook, JE | 1 |
| Blanchard, SG; Chang, KJ; Hong, JS; Lee, PH; Pugh, WW | 1 |
| Chang, KJ; Haddad, GG; Schaeffer, JI | 1 |
| Chen, C; de Riel, JK; Kunapuli, SP; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Bidlack, JM; Chung, NN; Dooley, CT; Houghten, RA; Pasternak, GW; Schiller, PW; Wilkes, BC | 1 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Ge, LJ; Hackler, L; Kastin, AJ; Zadina, JE | 1 |
| Law, PY; Prather, PL; Tsai, AW | 1 |
| Christinck, F; Cipris, S; Daniel, EE; Fox-Threlkeld, JE; Hruby, VJ; Woskowska, Z | 1 |
| Adler, MW; Geller, EB; Handler, CM; Piliero, TC | 1 |
| De Lander, GE; Keil, GJ | 1 |
| Hasegawa, A; Nagamatsu, K; Tagawa, Y; Uchida, S | 1 |
| Meyer, ME | 1 |
| Adams, JU; Adler, MW; Geller, EB; Tallarida, RJ | 1 |
| Chang, LR; Lee, CR; Lue, WM; Tao, PL | 1 |
| Cahill, CM; Sawynok, J; White, TD | 1 |
| Kolaj, M; Randic, M | 1 |
| Hauser, KF; Stiene-Martin, A; Zhou, R | 1 |
| Carney, JM; Harris-White, ME; Hauser, KF; Jackson, JA; Opanashuk, LA | 1 |
| Bivalacqua, TJ; Champion, HC; Friedman, DE; Kadowitz, PJ; Kastin, AJ; Zadina, JE | 1 |
| Garzón, J; Pol, O; Puig, MM; Sánchez-Blázquez, P; Valle, L | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
52 other study(ies) available for enkephalin, leucine and morphiceptin, n-me-phe(3)-
| Article | Year |
|---|---|
Opioid agonists binding and responses in SH-SY5Y cells.
Topics: Alprostadil; Analgesics; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP Phosphohydrolases; Humans; Meperidine; Morphinans; Naloxone; Narcotics; Oxymorphone; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1992 |
8-Bromo-cAMP blocks opioid activation of a voltage-gated potassium current in isolated hippocampal neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic GMP; Depression, Chemical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Ion Channel Gating; Male; Membrane Potentials; Neurons; Phosphorylation; Potassium; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1992 |
Characterization of opioid receptors mediating stimulation of adenylate cyclase activity in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; Male; Narcotic Antagonists; Olfactory Bulb; Oligopeptides; Opioid Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1992 |
Effect of mu-, kappa-, and delta-selective opioid agonists on thermoregulation in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Molecular Sequence Data; Morphinans; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Conformational features responsible for the binding of cyclic analogues of enkephalin to opioid receptors. III. Probable binding conformations of mu-agonists with phenylalanine in position 3.
Topics: Amino Acid Sequence; Endorphins; Enkephalins; Molecular Sequence Data; Molecular Structure; Oligopeptides; Opioid Peptides; Phenylalanine; Protein Conformation; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1991 |
In vitro evaluation of a casomorphin related pentapeptide, a competitive mu opioid receptor antagonist.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Receptors, Opioid, mu; Vas Deferens | 1991 |
Effect of opioid peptides on circular muscle of canine duodenum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Muscles; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid | 1991 |
Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig.
Topics: Animals; Autoradiography; Dynorphins; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Microelectrodes; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity; Synapses | 1990 |
Cholecystokinin octapeptide antagonized opioid analgesia mediated by mu- and kappa- but not delta-receptors in the spinal cord of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Proglumide; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Spinal Cord | 1990 |
Phorbol ester suppression of opioid analgesia in rats.
Topics: Analgesia; Animals; Calcium; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Peptide Fragments; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Spinal Cord; Tetradecanoylphorbol Acetate | 1990 |
Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation.
Topics: Animals; Barium; Barium Compounds; Cadmium; Cadmium Chloride; Chlorides; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; Narcotics; Neurons; Potassium; Rats; Rats, Inbred Strains | 1991 |
Spinally mediated opioid antidiarrheal effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidiarrheals; Body Weight; Diarrhea; Dinoprostone; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Pyrrolidines; Spinal Cord | 1991 |
[Cholecystokinin-octapeptide antagonizes the central depressive effect of opioid peptides in rats].
Topics: Animals; Blood Pressure; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Injections, Spinal; Male; Rats; Sincalide | 1991 |
Endogenous opioids released from perforant path modulate norepinephrine actions and inhibitory postsynaptic potentials in guinea pig CA3 pyramidal cells.
Topics: Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hippocampus; Male; Membrane Potentials; Naloxone; Norepinephrine; Propranolol; Pyramidal Tracts; Synapses | 1991 |
[3H][D-Pen2, D-Pen5]enkephalin binding to delta opioid receptors on intact neuroblastoma-glioma (NG 108-15) hybrid cells.
Topics: Animals; Binding, Competitive; Cell Survival; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hybrid Cells; Kinetics; Mice; Models, Biological; Morphine; Morphine Derivatives; Receptors, Opioid | 1990 |
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1990 |
Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antidiarrheals; Constipation; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
A comparison among antinociceptive bioassays for mu and delta agonists.
Topics: Analgesics; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
RX809055AX in vivo: a long lasting opioid antagonist at mu and delta receptors.
Topics: Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Oligopeptides; Rabbits; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1989 |
Peptide opioid antagonist separates peripheral and central opioid antitransit effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Interaction between highly selective mu and delta opioids in vivo at the rat spinal cord.
Topics: Analgesics; Animals; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1986 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
U50,488H differentially antagonizes the bladder effects of mu agonists at spinal sites.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Morphine Derivatives; Muscle Contraction; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1988 |
Mu opioid antagonist properties of a cyclic somatostatin octapeptide in vivo: identification of mu receptor-related functions.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred ICR; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1987 |
Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GABA Antagonists; Hippocampus; Interneurons; Naloxone; Oligopeptides; Rats; Receptors, Opioid | 1988 |
Regulation of ventilation and oxygen consumption by delta- and mu-opioid receptor agonists.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Naloxone; Oxygen; Oxygen Consumption; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration | 1985 |
Comparison of the antinociceptive and antitransit effects of DAGO and PLO17 in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastrointestinal Motility; Male; Mice; Mice, Inbred ICR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Continuous intrathecal opioid analgesia: tolerance and cross-tolerance of mu and delta spinal opioid receptors.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1987 |
Characterization of the binding of a morphine (mu) receptor-specific ligand: Tyr-Pro-NMePhe-D-Pro-NH2, [3H]-PL17.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Guanylyl Imidodiphosphate; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Substrate Specificity; Time Factors | 1987 |
Opposite effects of the delta- and mu-opioid receptor agonists on ventilation in conscious adult dogs.
Topics: Animals; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Respiratory Center | 1984 |
The third extracellular loop of the mu opioid receptor is important for agonist selectivity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Diprenorphine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Molecular Sequence Data; Morphine; Protein Conformation; Rats; Receptors, Opioid, mu; Sufentanil | 1995 |
An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Injections, Intraventricular; Male; Mice; Models, Molecular; Molecular Sequence Data; Naloxone; Opioid Peptides; Pain Measurement; Protein Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism | 1994 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Mu, delta, and kappa opiate receptor binding of Tyr-MIF-1 and of Tyr-W-MIF-1, its active fragments, and two potent analogs.
Topics: Amino Acid Sequence; Animals; Brain; Cerebellum; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Peptide Fragments; Peptides, Cyclic; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptic Membranes | 1994 |
Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Cell Differentiation; Colforsin; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Neuroblastoma; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Tumor Cells, Cultured | 1994 |
Identification of mechanisms and sites of actions of mu and delta opioid receptor activation in the canine intestine.
Topics: Amino Acid Sequence; Animals; Dogs; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Nitric Oxide; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Vasoactive Intestinal Peptide | 1994 |
Effect of ambient temperature on the ability of mu-, kappa- and delta-selective opioid agonists to modulate thermoregulatory mechanisms in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature Regulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Narcotics; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Temperature | 1994 |
Antinociception induced by intrathecal coadministration of selective adenosine receptor and selective opioid receptor agonists in mice.
Topics: Adenosine; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Narcotics; Phenethylamines; Receptors, Opioid; Receptors, Purinergic P1 | 1994 |
Mouse brain opioid receptor identification by direct ultraviolet photoaffinity labeling.
Topics: Affinity Labels; Animals; Binding Sites; Dithiothreitol; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Naloxone; Receptors, Opioid; Tritium; Tyrosine; Ultraviolet Rays | 1993 |
Behavioral effects of the mu-opioid peptide agonists DAMGO, DALDA, and PL017 on locomotor activities.
Topics: Amino Acid Sequence; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Motor Activity; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1993 |
Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Alteration of the interaction of mu-opioid receptor and G protein after chronic PL017 treatment in rats.
Topics: Analgesics; Animals; Drug Tolerance; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Male; Mesencephalon; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1995 |
Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes.
Topics: Adenosine; Animals; Drug Synergism; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Synaptosomes | 1996 |
mu-Opioid receptor-mediated reduction of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-activated current in dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Molecular Sequence Data; Neurons; Patch-Clamp Techniques; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 1996 |
Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Animals; Antibody Specificity; Astrocytes; Brain Chemistry; Calcium; Cell Cycle; Cell Division; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Flow Cytometry; Hippocampus; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Opioids disrupt Ca2+ homeostasis and induce carbonyl oxyradical production in mouse astrocytes in vitro: transient increases and adaptation to sustained exposure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Astrocytes; Calcium; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homeostasis; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Narcotics; Oxidative Stress; Reactive Oxygen Species; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat.
Topics: Adamantane; Animals; Blood Vessels; Endorphins; Endothelium, Vascular; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Meclofenamic Acid; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptin; Oligopeptides; Opioid Peptides; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Regional Blood Flow; Vasodilation; Vasodilator Agents | 1998 |
Antibodies and antisense oligodeoxynucleotides to mu-opioid receptors, selectively block the effects of mu-opioid agonists on intestinal transit and permeability in mice.
Topics: Animals; Antibodies, Blocking; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Gastrointestinal Transit; Injections, Intraventricular; Intestinal Absorption; Male; Mice; Morphine; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Receptors, Opioid, mu | 1999 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |