enkephalin, leucine and guanosine 5'-o-(3-thiotriphosphate)

Topics: Animals; Benzomorphans; Binding Sites; Binding, Competitive; Cattle; Cholic Acids; Corpus Striatum; Detergents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Receptors, Opioid; Solubility

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes

Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Male; Membranes; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes

Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Locus Coeruleus; Neuropeptide Y; Norepinephrine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Thionucleotides; Yohimbine

Topics: Adrenergic alpha-Agonists; Animals; Dialysis; Electric Conductivity; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Narcotics; Neurons; Norepinephrine; Pertussis Toxin; Potassium; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, delta; Somatostatin; Submucous Plexus; Thionucleotides; Time Factors; Virulence Factors, Bordetella

Topics: Animals; Barium; Barium Compounds; Cadmium; Cadmium Chloride; Chlorides; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; Narcotics; Neurons; Potassium; Rats; Rats, Inbred Strains

Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fatty Acids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism

Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Thionucleotides

Topics: Animals; Cell Line; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Phosphoric Monoester Hydrolases; Structure-Activity Relationship; Thionucleotides

Topics: Calcium; Calcium Channels; Cholera Toxin; Dihydropyridines; Enkephalin, Leucine; Ganglia, Spinal; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Intracellular Membranes; Narcotics; Neuroblastoma; Osmolar Concentration; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella

Topics: Animals; Autoradiography; Baclofen; Benzoxazines; Brain; Cannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-B Receptor Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Morpholines; Naloxone; Naphthalenes; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu

Topics: Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Narcotics; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured

Topics: Animals; Brain; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Morphine; Radioligand Assay; Rats; Receptors, Opioid, mu; Recombinant Proteins; RNA, Messenger

Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Calcium Channels; Catecholamines; Cattle; Cells, Cultured; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Membrane Potentials; Thionucleotides

Topics: Analgesics; Animals; Baclofen; Calcium Channel Blockers; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley

Topics: Adenylyl Cyclases; Animals; Brain; Cell Membrane; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Naltrexone; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation

Topics: Animals; Bradykinin; Calcium Channels; Electrophysiology; Enkephalin, Leucine; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Kinetics; Models, Biological; Neuroblastoma; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Potassium Channels; Tetrodotoxin; Tumor Cells, Cultured; Virulence Factors, Bordetella

Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tissue Distribution; Tritium

Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Cholic Acids; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Liposomes; Morphine; Naloxone; Narcotics; Receptors, Opioid, mu

Topics: Animals; Calcium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Neurons; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; Signal Transduction; Thionucleotides; Virulence Factors, Bordetella; Xenopus laevis

Topics: Analgesics; Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Membranes; Nociceptin Receptor; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sulfur Radioisotopes

Topics: Analgesics; Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Leucine; Enzyme Inhibitors; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kidney; Kinetics; Naphthalenes; Protein Kinase C; Receptors, Opioid, delta; Recombinant Proteins; Transfection

Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Molecular Sequence Data; Neurons; Patch-Clamp Techniques; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Opioid, mu; Somatostatin; Spinal Cord

Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella

Topics: Animals; Autoradiography; Cell Line; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Signal Transduction; Thalamus

Topics: Analgesics; Analgesics, Opioid; Animals; beta-Endorphin; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Locus Coeruleus; Male; Membrane Proteins; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sulfur Radioisotopes

Topics: Barium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Neuroblastoma; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured

Topics: Adenylyl Cyclases; Analgesics; Animals; Baculoviridae; Binding, Competitive; Blotting, Western; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunoblotting; Membrane Proteins; Mice; Naltrexone; Narcotic Antagonists; Ovary; Receptors, Opioid, delta; Recombinant Proteins; Spodoptera; Tritium; Viral Proteins

Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors

Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunoelectrophoresis; Male; Mice; Molecular Sequence Data; Periaqueductal Gray; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, mu

Topics: Animals; Benzamides; CHO Cells; Cloning, Molecular; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naltrexone; Narcotic Antagonists; Piperazines; Quinolines; Receptors, Opioid, delta; Sulfur Radioisotopes

Topics: Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Animals; Binding Sites; Cell Membrane; CHO Cells; Cholera Toxin; Cloning, Molecular; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Magnesium; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Proteins; Sodium; Sulfur Radioisotopes; Virulence Factors, Bordetella

Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sulfur Radioisotopes

Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Cholera Toxin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Narcotics; Pertussis Toxin; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon

Topics: Animals; Benzylidene Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Sodium

Topics: Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cholera Toxin; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanylyl Imidodiphosphate; Molecular Sequence Data; Oligopeptides; Pertussis Toxin; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Rats; Receptors, Opioid, mu; Virulence Factors, Bordetella

Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sulfur Radioisotopes

Topics: Analgesics, Opioid; Biotransformation; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Microscopy, Confocal; Morphine; Oligopeptides; Receptors, Opioid, mu

Topics: Animals; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Rats; Receptors, Opioid, mu; Signal Transduction; Thalamus

Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Ibogaine; Logistic Models; Male; Naloxone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stimulation, Chemical; Sulfur Radioisotopes

Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Hypothalamus; Neurosecretory Systems; Potassium Channels; Radioligand Assay; Receptors, Opioid, mu; Stimulation, Chemical; Sulfur Radioisotopes

Topics: Cell Membrane; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; MSH Release-Inhibiting Hormone; Narcotic Antagonists; Neuroblastoma; Oligopeptides; Receptors, Opioid; Tumor Cells, Cultured

Topics: Amygdala; Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Male; Mice; Oligopeptides; Receptors, Opioid, mu; Synaptic Membranes

Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morphine; Narcotic Antagonists; Narcotics; Nociceptors; Pain; Peptide Fragments; Peptides; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tritium

Topics: Animals; beta-Endorphin; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Opioid Peptides; Rats; Receptors, Opioid, mu; Recombinant Proteins; Tumor Cells, Cultured

Topics: Analgesics, Opioid; Animals; Brain Chemistry; Buffers; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Male; Membranes; Nociceptin; Nociceptin Receptor; Opioid Peptides; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord

Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Peptide Fragments; Phosphorylation; Polymerase Chain Reaction; Protein Kinase Inhibitors; Receptors, Opioid, delta; Staurosporine; Structure-Activity Relationship; Transfection

Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection

Topics: Animals; Autoradiography; Brain Stem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Narcotics; Pons; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sleep, REM; Sulfur Radioisotopes

Topics: Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Rats; Receptors, Opioid; Tumor Cells, Cultured

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membranes; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Morphine; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Tritium

Topics: Cyclic AMP; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Eye Proteins; Flow Cytometry; Glioma; Green Fluorescent Proteins; GTP Phosphohydrolases; GTP-Binding Protein Regulators; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Luminescent Proteins; Microscopy, Confocal; Nerve Tissue Proteins; Neuroblastoma; Phosphoproteins; Radioligand Assay; Receptors, Opioid; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured

Topics: Analgesics; Analgesics, Opioid; Animals; Benzoxazines; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Male; Morpholines; Naphthalenes; Neostriatum; Protein Precursors; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; RNA, Messenger; Sulfur Radioisotopes; Time Factors

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Brain; Cardiovascular Agents; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Membranes; Middle Aged; Myocardium; Nociceptin; Oligopeptides; Opioid Peptides; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes

Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Mutagenesis, Site-Directed; Naloxone; Peptide Fragments; Peptides; Protein Structure, Secondary; Rats; Receptors, Opioid, mu; Somatostatin; Transfection

Topics: Adrenal Glands; Agonistic Behavior; Analgesia; Animals; Benzamides; Body Temperature; Body Weight; Brain; Catecholamines; Chronic Disease; Corticosterone; Defecation; Dominance-Subordination; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Motor Activity; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Social Environment; Stress, Psychological

Topics: Animals; Cell Line; Cell Membrane; Cholesterol Esters; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Fluidity; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Conformation; Rats; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Tumor Cells, Cultured; Viscosity

Topics: Animals; CHO Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Membranes; Protein Binding; Receptors, Opioid, delta; Sulfur Radioisotopes; Tetrahydroisoquinolines; Tyrosine

Topics: Analgesics, Opioid; Animals; Benzamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membranes; Mice; Mice, Knockout; Oligopeptides; Pain Measurement; Piperazines; Protein Binding; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord

Topics: Amino Acid Sequence; Amino Acid Substitution; Analgesics; Animals; Cell Line; CHO Cells; Conserved Sequence; Cricetinae; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phenylalanine; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Tritium; Tyrosine

Topics: Biotransformation; Cell Line; Cell Membrane; Enkephalin, Leucine; Flow Cytometry; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Narcotic Antagonists; Pertussis Toxin; Receptors, Opioid, delta; Signal Transduction; Virulence Factors, Bordetella

Topics: Animals; Autoradiography; Behavior, Animal; Benzoxazines; Binding, Competitive; Body Temperature; Brain; Cannabinoids; Corticosterone; Cyclohexanols; Disease Models, Animal; Drug Tolerance; Enkephalins; Exploratory Behavior; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morpholines; Motor Activity; Naphthalenes; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger; Substance Withdrawal Syndrome; Transcription, Genetic; Tyrosine 3-Monooxygenase

Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Membrane; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalins; Gene Library; Guanosine 5'-O-(3-Thiotriphosphate); Hormones; Kinetics; Ligands; Molecular Sequence Data; Peptide Hormones; Protein Isoforms; Protein Precursors; Rats; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Tissue Distribution; Xenopus laevis

Topics: Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Inhibitory Concentration 50; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord; Stress, Physiological; Tail; Time Factors; Water

Topics: Alkaline Phosphatase; Benzamides; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mutation; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Structure-Activity Relationship

Topics: Adult; Aged; Aged, 80 and over; Autoradiography; Brain; Brain Chemistry; Catechol O-Methyltransferase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gene Expression; Genotype; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Situ Hybridization; Ligands; Male; Methionine; Middle Aged; Phenotype; Protein Precursors; Radioligand Assay; Receptors, Opioid, mu; RNA, Messenger; Valine

Topics: Animals; Binding, Competitive; Brain; Cholestasis; Dialysis Solutions; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Hypothalamus; Male; Microdialysis; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sulfur Radioisotopes

Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; In Situ Hybridization; Limbic System; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Protein Precursors; Pyrazoles; Radioligand Assay; Rats; Rats, Long-Evans; Reinforcement, Psychology; Rimonabant; Self Administration; Sulfur Isotopes; Tritium

Topics: Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Cannabis; Conditioning, Operant; Dynorphins; Enkephalins; Female; Guanosine 5'-O-(3-Thiotriphosphate); Heroin Dependence; In Situ Hybridization; Limbic System; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Protein Precursors; Rats; Rats, Long-Evans; Reaction Time

Topics: Animals; Binding, Competitive; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Down-Regulation; Dynorphins; Electrophoresis, Polyacrylamide Gel; Endorphins; Enkephalins; Flow Cytometry; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Peptides; Protease Inhibitors; Protein Precursors; Receptors, Opioid, kappa

Topics: Alcohol Drinking; Amidohydrolases; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Benzamides; Benzoxazines; Carbamates; Central Nervous System Depressants; Choice Behavior; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Hypothermia; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Motor Activity; Naphthalenes; Protein Binding; Protein Precursors; Receptor, Cannabinoid, CB1

Topics: Analgesics, Opioid; Animals; Anura; Base Sequence; Brain; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fishes; Guanosine 5'-O-(3-Thiotriphosphate); Naloxone; Narcotic Antagonists; Opioid Peptides; Protein Binding; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium

Topics: Alcohol Drinking; Animals; Autoradiography; Basal Ganglia; Body Temperature; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enkephalins; Ethanol; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Hypothermia; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nucleus Accumbens; Protein Precursors; Receptors, Opioid; Reflex, Righting; Reinforcement, Psychology; Reward; Tyrosine 3-Monooxygenase; Unconsciousness

Topics: Animals; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Neuralgia; Pain Threshold; Protein Precursors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Sciatic Nerve; Spinal Cord; Thalamus