enkephalin, leucine and fentanyl

enkephalin, leucine has been researched along with fentanyl in 96 studies

Research

Studies (96)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (51.04)	18.7374
1990's	39 (40.63)	18.2507
2000's	2 (2.08)	29.6817
2010's	6 (6.25)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chung, NN; Guo, J; Lemieux, C; Lu, Y; Schiller, PW; Weltrowska, G; Wilkes, BC	1
Meanwell, NA	1
Colpaert, FC; Janssen, PA; Niemegeers, CJ; Van Ree, JM	1
Galt, RH	1
Laubie, M; Schmitt, H; Vincent, M	1
Colpaert, FC; Smyth, DG; van Ree, JM	1
Costa, EM; Hoffmann, BB; Loew, GH	1
Gintzler, AR; Xu, H	3
Chi, ZQ; Masuo, Y; Pélaprat, D; Rostène, W; Wang, H	1
Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C	1
Brine, GA; Carroll, FI; Jacobson, AE; Rice, KC; Rothman, RB; Seggel, M; Xu, H	1
Chi, ZQ; Pélaprat, D; Roques, BP; Rostène, W; Vanhove, A; Wang, H	1
Mjanger, E; Yaksh, TL	1
Elde, RP; Lacey, CB; Miller, KE; Seybold, VS; Stevens, CW	1
Barnes, NM; Bunce, KT; Naylor, RJ; Rudd, JA	1
Bennett, GJ; Kajander, KC; Seybold, VS; Stevens, CW	1
Cowan, A; Murray, CW	1
Freye, E; Schenk, G; Schnitzler, M	1
Chi, ZQ; Kopp, N; Pélaprat, D; Roques, BP; Rostène, W; Sarrieau, A; Vanhove, A; Wang, H	1
Buydens, P; Finné, E; Govaerts, J; Matton, A; Vanhaelst, L	1
Ayesta, FJ; Flórez, J	1
Donnerer, J; Lembeck, F	1
Yaksh, TL	1
Stevens, CW; Yaksh, TL	2
Bykov, V; George, C; Jacobson, AE; Kim, CH; Klee, WA; Long, JB; Mattson, MV; Rice, KC; Rothman, RB; Streaty, RA	1
Rooney, KF; Sewell, RD	1
Gintzler, AR; Smolens, I; Xu, H	1
De Vries, TJ; Delay-Goyet, P; Mulder, AH; Roques, BP; Schoffelmeer, AN	1
Chiba, S; Fujino, M; Hasegawa, Y; Nishida, N; Wakimasu, M	2
Blancquaert, JP; Lefebvre, RA; Willems, JL	1
Bowen, WD; Jacobson, AE; Rice, KC; Rodrigues, PA; Wanzor, TE	1
Kitchen, I; Yeadon, M	3
Hill, RG; Hughes, J; Johnson, MA	1
Heijna, MH; Hogenboom, F; Mulder, AH; Rice, KC; Schoffelmeer, AN	1
Galzi, JL; Goeldner, M; Hirth, C; Ilien, B; Mejean, A	1
Durant, PA; Yaksh, TL	1
Jensen, TS; Yaksh, TL	1
Carter, BD; Clark, MJ; Medzihradsky, F	1
Brown, DR; Miller, RJ; Vinayek, R	1
Garzón, J; Herz, A; Schulz, R	1
Burke, TR; Danks, JA; Herkenham, M; Jacobson, AE; Rice, KC; Rothman, RB	1
Aceto, MD; Bajwa, BS; Harris, LS; Jacobson, AE; Klee, WA; Lessor, RA; May, EL; Rice, KC; Smith, CB; Streaty, RA	1
Bykov, V; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB	1
Bardon, T; Ruckebusch, Y	1
Bowen, WD; Burke, TR; Bykov, V; Jacobson, AE; Pert, CB; Rice, KC; Rothman, RB; Schumacher, UK	1
Burke, TR; Jacobson, AE; Pert, CB; Rice, KC; Rothman, RB	1
Burke, TR; Danks, JA; Jacobson, AE; Pert, CB; Rice, KC; Rothman, RB	2
Bardon, T; Pairet, M; Ruckebusch, Y	1
Bellet, M; Elghozi, JL; Meyer, P; Pernollet, MG; Schmitt, H	1
Rubini, P; Schulz, R; Wüster, M	1
Day, AR; Freer, RJ; Liao, CS	1
Herz, A; Schulz, R; Wüster, M	1
Pairet, M; Ruckebusch, Y	1
Herz, A; Krenss, H; Schulz, R; Wüster, M	1
Gähwiler, BH	1
Herz, A; Shearman, GT	1
Du, C; Ferré, JP; Ruckebusch, Y	1
Chaillet, P; Costentin, J; Marçais-Collado, H	1
Essawi, MY; Portoghese, PS	1
Burns, P; Combie, JD; Nugent, TE; Tobin, T; Weld, JM	1
Duka, T; Herz, A; Wüster, M	1
Fujinami, T; Nishimura, M; Saeki, T; Sato, N; Watanabe, Y	1
Nahorski, SR; Traynor, JR	1
Chen, CH; Chen, CY; Li, YL; Lian, HS; Sun, YG	1
Atcheson, R; Lambert, DG; Rowbotham, DJ	1
Lambert, DG; Smart, D; Smith, G	1
Brine, GA; Carroll, FI; Ni, Q; Partilla, JS; Rothman, RB; Stark, PA; Xu, H	1
De Vries, TJ; Hogenboom, F; Mulder, AH; Schoffelmeer, AN	1
Davis, T; Duttaroy, A; Shah, S; Yoburn, BC	1
Fitzgerald, LW; Teitler, M	1
Han, JS; Kang, HG; Li, CQ; Liu, NJ; Xu, C; Xu, T; Yu, YX	1
Chan, KW; Duttory, A; Yoburn, BC	1
Bilsky, EJ; Hruby, VJ; Inturrisi, CE; Porreca, F; Sadée, W	1
Albrecht, E; Baeger, I; Berger, H; Fechner, K; Heinrich, N; Lorenz, D; Samovilova, N	1
Rothe, KS; Stevens, CW	1
Brine, GA; Carroll, FI; Chen, C; Lai, J; Liu-Chen, LY; Lu, YF; Partilla, JS; Porreca, F; Rice, KC; Rothman, RB; Sadee, W; Xu, H	1
Schäfer, M; Stein, C; Zhou, L	1
Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB	1
Celver, JP; Chavkin, C; Kovoor, A; Wu, A	1
Cao, XD; Cui, DF; Li, MY; Qi, ZW; Wu, GC; Xu, SF; Zhang, XL; Zhu, CB	1
Garzón, J; Pol, O; Puig, MM; Sánchez-Blázquez, P; Valle, L	1
Chen, ZW; Han, JS; Wang, Y; Yang, K	1
Virk, MS; Williams, JT	1
Lebedev, AA; Shabanov, PD	1
Bilsky, EJ; Cain, JP; Hruby, VJ; Hu, J; Kumirov, VK; Lee, YS; Podolsky, AT; Sandweiss, A; Vanderah, TW; Vardanyan, RS	1
Chen, ZY; Fu, X; Wang, H; Xu, H; Xu, W	1
Abbruscato, TJ; Hruby, VJ; Islam, MR; Karamyan, VT; Lee, YS; Yang, L	1
Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L	1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1

Reviews

1 review(s) available for enkephalin, leucine and fentanyl

Article	Year
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. Journal of medicinal chemistry, 2018, 07-26, Volume: 61, Issue:14 Topics: Alkanes; Animals; Drug Design; Fluorine; Halogenation; Humans	2018

Other Studies

95 other study(ies) available for enkephalin, leucine and fentanyl

Article	Year
"Carba"-analogues of fentanyl are opioid receptor agonists. Journal of medicinal chemistry, 2010, Apr-08, Volume: 53, Issue:7 Topics: Animals; Fentanyl; Guanidine; Guinea Pigs; Male; Mice; Models, Molecular; Molecular Conformation; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens	2010
Narcotic cueing properties of intraventricularly administered sufentanil, fentanyl, morphine and met-enkephalin. European journal of pharmacology, 1978, Jan-01, Volume: 47, Issue:1 Topics: Analgesics, Opioid; Anilides; Animals; Cues; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Fentanyl; Injections, Intraventricular; Morphine; Piperidines; Rats; Time Factors	1978
The opiate anomalies--another possible explanation? The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:11 Topics: Benzomorphans; Chemical Phenomena; Chemistry; Enkephalins; Fentanyl; Narcotics; Piperidines; Receptors, Opioid; Structure-Activity Relationship	1977
Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anaesthetized dogs. European journal of pharmacology, 1979, Nov-16, Volume: 59, Issue:3-4 Topics: Animals; Dogs; Electric Stimulation; Endorphins; Enkephalins; Female; Fentanyl; Heart Rate; Hemodynamics; Injections; Male; Medulla Oblongata; Microinjections; Splanchnic Nerves; Vagus Nerve	1979
Dependence creating properties of lipotropin C-fragment (beta-endorphin): evidence for its internal control of behavior. Life sciences, 1979, Feb-05, Volume: 24, Issue:6 Topics: Animals; Behavior, Animal; Discrimination, Psychological; Endorphins; Enkephalins; Fentanyl; Heroin; Humans; Male; Raphe Nuclei; Rats; Self Administration; Substance-Related Disorders	1979
Opioid agonists binding and responses in SH-SY5Y cells. Life sciences, 1992, Volume: 50, Issue:1 Topics: Alprostadil; Analgesics; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP Phosphohydrolases; Humans; Meperidine; Morphinans; Naloxone; Narcotics; Oxymorphone; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured	1992
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium. Proceedings of the National Academy of Sciences of the United States of America, 1992, Mar-01, Volume: 89, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil	1992
Effect of brain lesions on [3H]ohmefentanyl binding site densities in the rat striatum and substantia nigra. Chemical & pharmaceutical bulletin, 1992, Volume: 40, Issue:9 Topics: Animals; Brain Injuries; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Male; Rats; Rats, Wistar; Receptors, Opioid; Substantia Nigra	1992
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors. European journal of pharmacology, 1992, Mar-24, Volume: 213, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1992
RTI-4614-4: an analog of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites. Life sciences, 1991, Volume: 48, Issue:23 Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; In Vitro Techniques; Kinetics; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1991
[3H]ohmefentanyl preferentially binds to mu-opioid receptors but also labels sigma-sites in rat brain sections. European journal of pharmacology, 1991, Feb-14, Volume: 193, Issue:3 Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding Sites; Brain; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Male; Molecular Sequence Data; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substrate Specificity; Tritium	1991
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2 Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil	1991
Biochemical characterization and regional quantification of mu, delta and kappa opioid binding sites in rat spinal cord. Brain research, 1991, May-31, Volume: 550, Issue:1 Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Kinetics; Male; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sufentanil; Tritium	1991
The actions of fentanyl to inhibit drug-induced emesis. Neuropharmacology, 1991, Volume: 30, Issue:10 Topics: Animals; Antiemetics; Apomorphine; Autoradiography; Brain Stem; Cisplatin; Copper; Copper Sulfate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Fentanyl; Ferrets; Male; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Vomiting	1991
Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy. Pain, 1991, Volume: 46, Issue:3 Topics: Analgesics; Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Ligands; Male; Nervous System Diseases; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Spinal Cord; Sufentanil	1991
Opioids can produce a concentration-dependent naloxone-reversible enhancement of inhibition of evoked enkephalin release. NIDA research monograph, 1990, Volume: 105 Topics: Analgesics; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Naloxone; Narcotics; Parasympatholytics; Sufentanil; Thionucleotides; Virulence Factors, Bordetella	1990
Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release. Proceedings of the National Academy of Sciences of the United States of America, 1991, Jun-01, Volume: 88, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle, Smooth; Myenteric Plexus; Narcotics; Pertussis Toxin; Pyrrolidines; Sufentanil; Virulence Factors, Bordetella	1991
Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil	1991
Opioid-induced respiratory depression and analgesia may be mediated by different subreceptors. Pharmaceutical research, 1991, Volume: 8, Issue:2 Topics: Analgesia; Animals; Dogs; Enkephalin, Leucine; Evoked Potentials, Somatosensory; Fentanyl; Morphinans; Narcotics; Receptors, Opioid; Respiration	1991
Characterization and distribution of [3H]ohmefentanyl binding sites in the human brain. Synapse (New York, N.Y.), 1991, Volume: 8, Issue:3 Topics: Adult; Aged; Autoradiography; Basal Ganglia; Binding Sites; Binding, Competitive; Brain Chemistry; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Fentanyl; Humans; In Vitro Techniques; Kinetics	1991
The growth hormone secretory response to fentanyl in rat: an involvement of mu type receptors. Journal of endocrinological investigation, 1990, Volume: 13, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Leucine; Fentanyl; Growth Hormone; Male; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu	1990
Tolerance to the respiratory actions of opiates: withdrawal tolerance and asymmetrical cross-tolerance. European journal of pharmacology, 1990, Jan-03, Volume: 175, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Narcotics; Rats; Rats, Inbred Strains; Respiratory System; Substance Withdrawal Syndrome; Sufentanil	1990
Opioid control of the function of primary afferent substance P fibres. European journal of pharmacology, 1985, Aug-27, Volume: 114, Issue:3 Topics: Afferent Pathways; Animals; Electric Stimulation; Enkephalins; Fentanyl; In Vitro Techniques; Naloxone; Perfusion; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Vasodilation	1985
Substance P release from knee joint afferent terminals: modulation by opioids. Brain research, 1988, Aug-23, Volume: 458, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Afferent Pathways; Animals; Capsaicin; Cats; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Hindlimb; Joints; Narcotics; Pyrrolidines; Reference Values; Sciatic Nerve; Substance P; Sufentanil	1988
Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:1 Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Infusions, Parenteral; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Reference Values; Sufentanil	1989
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Acylation; Adenylyl Cyclase Inhibitors; Analgesia; Animals; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Glioma; Hybrid Cells; Indicators and Reagents; Ligands; Male; Molecular Structure; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	1989
Magnitude of opioid dependence after continuous intrathecal infusion of mu- and delta-selective opioids in the rat. European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3 Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders; Sufentanil; Time Factors	1989
Evaluation of selective actions of dopamine D-1 and D-2 receptor agonists and antagonists on opioid antinociception. European journal of pharmacology, 1989, Sep-22, Volume: 168, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dopamine Agents; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ergolines; Fentanyl; Injections, Intraventricular; Male; Mice; Narcotics; Nociceptors; Pyrrolidines; Quinpirole; Reaction Time; Receptors, Dopamine; Sufentanil; Sulpiride	1989
Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin. Brain research, 1989, Dec-11, Volume: 504, Issue:1 Topics: Action Potentials; Animals; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Myenteric Plexus; Naloxone; Sufentanil	1989
Selective effects of [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 (O-t-butyl), two new enkephalin analogues, on neurotransmitter release and adenylate cyclase in rat brain slices. European journal of pharmacology, 1989, Nov-07, Volume: 170, Issue:3 Topics: Adenylyl Cyclases; Alkylating Agents; Animals; Brain; Corpus Striatum; Cyclic AMP; Dopamine; Electric Stimulation; Enkephalins; Fentanyl; Isothiocyanates; Male; Neurotransmitter Agents; Oligopeptides; Rats; Rats, Inbred Strains	1989
Discriminative stimulus effects of enkephalin analogs, EK-209 and EK-399, in rats. European journal of pharmacology, 1989, Dec-12, Volume: 174, Issue:1 Topics: Analgesics; Animals; Codeine; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalins; Fentanyl; Generalization, Stimulus; Levallorphan; Male; Morphine; Pentazocine; Rats; Rats, Inbred Strains	1989
Reinforcing effects of the enkephalin analogs, EK-209 and EK-399, in rats. European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3 Topics: Animals; Codeine; Dose-Response Relationship, Drug; Enkephalins; Fentanyl; Levallorphan; Male; Pentazocine; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Administration	1989
Antiaversive properties of opioids in the conditioned taste aversion test in the rat. Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:3 Topics: Animals; Avoidance Learning; Conditioning, Classical; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fentanyl; Male; Methadone; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Taste	1987
Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes. Biochemical pharmacology, 1988, Feb-01, Volume: 37, Issue:3 Topics: Adenylate Cyclase Toxin; Alkylating Agents; Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; GTP-Binding Proteins; Intracellular Membranes; Isothiocyanates; Kinetics; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes; Virulence Factors, Bordetella	1988
Binding characteristics of [D-Ala2-MePhe4-Glyol5] enkephalin and [D-Pen2,D-Pen5] enkephalin in rat brain: inhibition studies with fentanyl-like drugs. NIDA research monograph, 1986, Volume: 75 Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Kinetics; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1986
Comparison of the effects of calcium concentration on mu and kappa agonist actions in the guinea pig ileum. NIDA research monograph, 1986, Volume: 75 Topics: Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1986
Fentanyl isothiocyanate reveals the existence of physically associated mu- and delta-opioid receptors mediating inhibition of adenylate cyclase in rat neostriatum. European journal of pharmacology, 1988, Apr-27, Volume: 149, Issue:1-2 Topics: Adenylyl Cyclase Inhibitors; Animals; Caudate Nucleus; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; In Vitro Techniques; Isothiocyanates; Male; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1988
Comparative binding of mu and delta selective ligands in whole brain and pons/medulla homogenates from rat: affinity profiles of fentanyl derivatives. Neuropharmacology, 1988, Volume: 27, Issue:4 Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Male; Medulla Oblongata; Narcotic Antagonists; Pons; Rats; Rats, Inbred Strains	1988
A mu-opioid receptor-filter assay. Rapid estimation of binding affinity of ligands and reversibility of long-lasting ligand-receptor complexes. Biochemical pharmacology, 1988, Oct-15, Volume: 37, Issue:20 Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Filtration; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sufentanil	1988
Epidural injections of bupivacaine, morphine, fentanyl, lofentanil, and DADL in chronically implanted rats: a pharmacologic and pathologic study. Anesthesiology, 1986, Volume: 64, Issue:1 Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Bupivacaine; Catheterization; Catheters, Indwelling; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epidural Space; Fentanyl; Male; Morphine; Motor Activity; Naloxone; Rats; Rats, Inbred Strains; Reaction Time; Time Factors	1986
Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique. Brain research, 1986, May-07, Volume: 372, Issue:2 Topics: Analgesics, Opioid; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Medulla Oblongata; Morphine; Naloxone; Oligopeptides; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sufentanil	1986
Selectivity of ligand binding to opioid receptors in brain membranes from the rat, monkey and guinea pig. European journal of pharmacology, 1988, Apr-13, Volume: 148, Issue:3 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain Chemistry; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Haplorhini; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Sufentanil; Tritium	1988
Differences in the characteristics of opioid receptor binding in the rat and marmoset. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:10 Topics: Animals; Callitrichinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Male; Rats; Receptors, Opioid; Species Specificity	1988
Tolerance and cross-tolerance to the antisecretory effects of enkephalins on the guinea-pig ileal mucosa. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3 Topics: Animals; Biological Transport; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Guinea Pigs; Ileum; Intestinal Mucosa; Narcotic Antagonists; Receptors, Opioid	1985
Evidence for the epsilon-type of opioid receptor in the rat vas deferens. Molecular pharmacology, 1985, Volume: 28, Issue:1 Topics: Animals; Binding, Competitive; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Synergism; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Fentanyl; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens	1985
Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides, 1985, Volume: 6, Issue:3 Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; In Vitro Techniques; Isothiocyanates; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta	1985
Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry Journal of medicinal chemistry, 1986, Volume: 29, Issue:11 Topics: Animals; Brain; Enkephalin, Leucine; Fentanyl; In Vitro Techniques; Isothiocyanates; Ligands; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Thebaine; Thiocyanates	1986
Intracerebroventricular administration of superFIT and its enantiomer to rats: evidence for in vivo acylation of [3H]DADL binding sites. Neuropeptides, 1987, Volume: 9, Issue:3 Topics: Acylation; Animals; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Indicators and Reagents; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism	1987
Comparative effects of opiate agonists on proximal and distal colonic motility in dogs. European journal of pharmacology, 1985, Apr-16, Volume: 110, Issue:3 Topics: Animals; Colon; Cyclazocine; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Injections, Intravenous; Injections, Spinal; Narcotics; Time Factors	1985
Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: evidence for a two-site allosteric model. Neuropeptides, 1984, Volume: 4, Issue:3 Topics: Alkylating Agents; Allosteric Regulation; Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Isothiocyanates; Kinetics; Male; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates	1984
Morphine noncompetitively inhibits [3H]leucine enkephalin binding to membranes lacking type-II delta binding sites: evidence for a two-site allosteric model. Neuropeptides, 1984, Volume: 4, Issue:3 Topics: Allosteric Regulation; Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Leucine; Fentanyl; Isothiocyanates; Kinetics; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta	1984
Ionic conditions differentially affect 3H-DADL binding to type-I and type-II opiate delta receptors in vitro. Neuropeptides, 1984, Volume: 4, Issue:3 Topics: Animals; Brain; Calcium; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Isothiocyanates; Kinetics; Manganese; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Thiocyanates	1984
Opioid control of the ruminant stomach motility: functional importance of mu, kappa and delta receptors. Life sciences, 1984, Oct-22, Volume: 35, Issue:17 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep; Stomach	1984
Central cardiovascular effects of narcotic analgesics and enkephalins in rats. British journal of pharmacology, 1980, Volume: 71, Issue:2 Topics: Analgesics, Opioid; Animals; Autonomic Nervous System; Blood Pressure; Endorphins; Enkephalins; Fentanyl; Heart Rate; Hemodynamics; Male; Morphine; Oxygen Consumption; Rats	1980
The preference of putative pro-enkephalins for different types of opiate receptors. Life sciences, 1981, Sep-21, Volume: 29, Issue:12 Topics: Animals; Benzomorphans; Brain; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Morphine; Protein Precursors; Rats; Receptors, Opioid; Vas Deferens	1981
Evidence for a single opioid receptor type on the field stimulated rat vas deferens. Life sciences, 1981, Dec-21, Volume: 29, Issue:25 Topics: Animals; Benzimidazoles; beta-Endorphin; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Etorphine; Fentanyl; Male; Morphine; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sufentanil; Vas Deferens	1981
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:1 Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1984
Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies. Life sciences, 1984, Oct-15, Volume: 35, Issue:16 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Cyclazocine; Dynorphins; Electric Conductivity; Enkephalins; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1984
Tritiated-6-beta-fluoro-6-desoxy-oxymorphone: a highly selective ligand for the opiate mu receptor whose binding is characterized by low nonspecific binding. Neuropeptides, 1984, Volume: 4, Issue:4 Topics: Animals; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Hydromorphone; Isothiocyanates; Kinetics; Oxymorphone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Tomography, Emission-Computed	1984
Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens. Nature, 1980, May-22, Volume: 285, Issue:5762 Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electric Stimulation; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Humans; Male; Mice; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Substance-Related Disorders; Sufentanil; Vas Deferens	1980
Excitatory action of opioid peptides and opiates on cultured hippocampal pyramidal cells. Brain research, 1980, Jul-21, Volume: 194, Issue:1 Topics: Animals; Culture Techniques; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Evoked Potentials; Fentanyl; Hippocampus; Morphine; Naloxone; Neurons; Rats; Synaptic Transmission	1980
D-Ala2,D-Leu5-enkephalin generalizes to a discriminative stimulus produced by fentanyl but not ethylketocyclazocine. Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:2 Topics: Animals; Cyclazocine; Discrimination, Psychological; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Fentanyl; Generalization, Stimulus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid	1982
In vivo modulation of intestinal motility and sites of opioid effects in the rat. Regulatory peptides, 1984, Volume: 9, Issue:1-2 Topics: Animals; Electrophysiology; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Gastrointestinal Motility; Intestine, Small; Male; Rats; Rats, Inbred Strains	1984
Catatonic or hypotonic immobility induced in mice by intracerebroventricular injection of mu or kappa opioid receptor agonists as well as enkephalins or inhibitors of their degradation. Life sciences, 1983, Nov-21, Volume: 33, Issue:21 Topics: Animals; Benzomorphans; Catatonia; Cyclazocine; Enkephalins; Ethylketocyclazocine; Fentanyl; Humans; Immobilization; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics	1983
Synthesis and evaluation of 1- and 2-substituted fentanyl analogues for opioid activity. Journal of medicinal chemistry, 1983, Volume: 26, Issue:3 Topics: Animals; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Morphine; Naloxone; Vas Deferens	1983
Effects of enkephalins versus opiates on locomotor activity of the horse. Research communications in chemical pathology and pharmacology, 1982, Volume: 35, Issue:3 Topics: Animals; Blinking; Blood Pressure; Body Temperature; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fentanyl; Horses; Morphine; Motor Activity; Respiration	1982
Benzodiazepines modulate striatal enkephalin levels via a GABAergic mechanism. Life sciences, 1980, Mar-10, Volume: 26, Issue:10 Topics: Aminooxyacetic Acid; Animals; Bicuculline; Corpus Striatum; Diazepam; Endorphins; Enkephalin, Methionine; Enkephalins; Fentanyl; gamma-Aminobutyric Acid; Hypothalamus; Male; Muscimol; Radioimmunoassay; Rats	1980
Electrophysiological demonstration and activation of mu-opioid receptors in the rabbit sinoatrial node. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1 Topics: Action Potentials; Animals; Enkephalin, Leucine; Fentanyl; Microelectrodes; Naltrexone; Narcotic Antagonists; Narcotics; Patch-Clamp Techniques; Rabbits; Receptors, Opioid, mu; Sinoatrial Node	1995
Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Molecular pharmacology, 1995, Volume: 47, Issue:4 Topics: Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Narcotics; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured	1995
[The studies on electronic structure and structure-activity relationships of [Leu5]-enkephalin]. Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:11 Topics: Analgesics, Opioid; Electrochemistry; Enkephalin, Leucine; Fentanyl; Humans; Molecular Conformation; Molecular Structure; Morphine; Structure-Activity Relationship	1993
Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells. British journal of anaesthesia, 1994, Volume: 72, Issue:1 Topics: Atropine; Carbachol; Cell Differentiation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Humans; Morphine; Neuroblastoma; Norepinephrine; Potassium; Receptors, Muscarinic; Tumor Cells, Cultured	1994
mu-Opioid receptor stimulation of inositol (1,4,5)trisphosphate formation via a pertussis toxin-sensitive G protein. Journal of neurochemistry, 1994, Volume: 62, Issue:3 Topics: Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Humans; Inositol 1,4,5-Trisphosphate; Morphine; Narcotic Antagonists; Neuroblastoma; Pertussis Toxin; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella	1994
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains. Synapse (New York, N.Y.), 1993, Volume: 15, Issue:4 Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Ligands; Molecular Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism	1993
Mu- and delta-opioid receptors inhibitorily linked to dopamine-sensitive adenylate cyclase in rat striatum display a selectivity profile toward endogenous opioid peptides different from that of presynaptic mu, delta and kappa receptors. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Acetylcholine; Adenylyl Cyclases; Animals; Corpus Striatum; Dopamine; Endorphins; Enkephalins; Fentanyl; In Vitro Techniques; Isothiocyanates; Male; Naloxone; Norepinephrine; Protease Inhibitors; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, Presynaptic; Sulpiride	1993
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration. Brain research bulletin, 1994, Volume: 33, Issue:2 Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation	1994
Quantitative autoradiographic analysis of [3H]carfentanil binding to mu opiate receptors in the rat brain. Synapse (New York, N.Y.), 1993, Volume: 14, Issue:2 Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tissue Distribution; Tritium	1993
Cholecystokinin octapeptide reverses mu-opioid-receptor-mediated inhibition of calcium current in rat dorsal root ganglion neurons. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3 Topics: Animals; Calcium Channel Blockers; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Ganglia, Spinal; Ion Channel Gating; Male; Neurons; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide	1995
Magnitude of tolerance to fentanyl is independent of mu-opioid receptor density. European journal of pharmacology, 1997, Jan-29, Volume: 319, Issue:2-3 Topics: Analgesics; Animals; Brain Chemistry; Cinnamates; Dose-Response Relationship, Drug; Down-Regulation; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Kinetics; Male; Mice; Morphine Derivatives; Narcotic Antagonists; Narcotics; Pain Measurement; Reaction Time; Receptors, Opioid, mu	1997
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice. Pain, 1996, Volume: 68, Issue:2-3 Topics: Analgesics, Opioid; Animals; Binding, Competitive; Dizocilpine Maleate; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Fentanyl; Isoquinolines; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu	1996
Influence of continuous levels of fentanyl in rats on the mu-opioid receptor in the central nervous system. Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1 Topics: Adenylyl Cyclases; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Guanosine Triphosphate; Male; Membranes; Rats; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord	1997
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians. European journal of pharmacology, 1997, Jul-16, Volume: 331, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor. Synapse (New York, N.Y.), 1998, Volume: 28, Issue:2 Topics: Affinity Labels; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fentanyl; Melphalan; Membrane Proteins; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; Stereoisomerism	1998
Cholecystokinin inhibits peripheral opioid analgesia in inflamed tissue. Neuroscience, 1998, Volume: 82, Issue:2 Topics: Analgesics, Opioid; Animals; Cholecystokinin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Fentanyl; Male; Naphthalenes; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Protein Kinase C; Rats; Rats, Wistar; Receptors, Cholecystokinin	1998
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor. European journal of pharmacology, 1998, Aug-07, Volume: 354, Issue:2-3 Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors	1998
Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Molecular pharmacology, 1998, Volume: 54, Issue:4 Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; G-Protein-Coupled Receptor Kinase 3; G-Protein-Coupled Receptor Kinase 5; Humans; Kinetics; Morphine; Potassium Channels; Protein Serine-Threonine Kinases; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Opioid, mu; Sensitivity and Specificity; Xenopus laevis	1998
Antagonistic effect of orphanin FQ on opioid analgesia in rat. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analgesics, Opioid; Animals; Enkephalin, Leucine; Fentanyl; Injections, Intraventricular; Injections, Spinal; Male; Nociceptin; Opioid Peptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid	1998
Antibodies and antisense oligodeoxynucleotides to mu-opioid receptors, selectively block the effects of mu-opioid agonists on intestinal transit and permeability in mice. British journal of pharmacology, 1999, Volume: 127, Issue:2 Topics: Animals; Antibodies, Blocking; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Gastrointestinal Transit; Injections, Intraventricular; Intestinal Absorption; Male; Mice; Morphine; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Receptors, Opioid, mu	1999
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans. Neuroscience letters, 2001, Feb-09, Volume: 298, Issue:3 Topics: Acids; Analgesics; Analgesics, Opioid; Animals; Cell Differentiation; CHO Cells; Cricetinae; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Fentanyl; Humans; Naloxone; Narcotic Antagonists; Neuroblastoma; Neurons; Tumor Cells, Cultured	2001
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization. Molecular pharmacology, 2008, Volume: 73, Issue:4 Topics: Analgesics, Opioid; Animals; Down-Regulation; Electrophysiology; Enkephalins; Etorphine; Fentanyl; In Vitro Techniques; Male; Naltrexone; Oxymorphone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu	2008
[The extended amygdala system and self-stimulation of the lateral hypothalamus in rats: modulation with opiates and opioids]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2011, Volume: 97, Issue:2 Topics: Amphetamine; Amygdala; Analgesics, Opioid; Anesthetics, Local; Animals; Barbiturates; Benzazepines; Corticotropin-Releasing Hormone; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enkephalin, Leucine; Fentanyl; Hypnotics and Sedatives; Hypothalamus; Lidocaine; Male; Neuroprotective Agents; Neurotransmitter Agents; Pentobarbital; Peptide Fragments; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Self Stimulation; Sulpiride	2011
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life sciences, 2013, Dec-18, Volume: 93, Issue:25-26 Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalins; Fentanyl; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu	2013
Effect of intravenous general anaesthesia with epidural block on the expression of pre-endogenous opioid peptide genes. The Journal of international medical research, 2014, Volume: 42, Issue:3 Topics: Abdomen; Adult; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intravenous; beta-Endorphin; Bupivacaine; Dynorphins; Enkephalin, Leucine; Enkephalins; Female; Fentanyl; Gene Expression; Humans; Male; Midazolam; Middle Aged; Pain; Prospective Studies; Protein Precursors; Radioimmunoassay; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vecuronium Bromide	2014
Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment. Current pharmaceutical design, 2016, Volume: 22, Issue:42 Topics: Analgesics, Opioid; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Enkephalins; Fentanyl; Male; Mice; Molecular Conformation; Neurons; Neuroprotective Agents; Stroke; Structure-Activity Relationship	2016
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Molecular pharmacology, 1994, Volume: 45, Issue:2 Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software	1994
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998