enkephalin, leucine has been researched along with ethylketocyclazocine in 155 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 125 (80.65) | 18.7374 |
| 1990's | 30 (19.35) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coale, EH; Hein, DW; Herling, S; Valentino, RJ; Woods, JH | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Besse, D; Besson, JM; Lombard, MC | 1 |
| Chiba, S; Nishida, N; Yasuhara, Y | 1 |
| Bhargava, HN; Gulati, A | 1 |
| Gudehithlu, KP; McDonald, JS; Rattan, AK; Tejwani, GA | 1 |
| Bodnar, R; Pasternak, GW; Paul, D | 1 |
| Kuhar, MJ; Wamsley, JK; Zarbin, MA | 1 |
| Duckles, SP; Li, YJ | 1 |
| Benyhe, S; Borsodi, A; Varga, E; Wollemann, M | 1 |
| Hoss, W; Periyasamy, S | 1 |
| Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN | 1 |
| Hanissian, SH; Tejwani, GA | 1 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| Magnan, J; Tiberi, M | 1 |
| Besse, D; Besson, JM; Lombard, MC; Roques, BP; Zajac, JM | 1 |
| Barnette, MS; Barone, FC; Callahan, JF; Grous, M; Manning, CD | 1 |
| deGroat, WC; Hisamitsu, T; Nagel, J; Roppolo, JR; Thor, KB; Tuttle, P | 1 |
| Fedynyshyn, JP; Kwiat, G; Lee, NM | 1 |
| Bueno, L; Gué, M; Junien, JL | 1 |
| Brantl, V; Liebmann, C; Schrader, U | 1 |
| Bhargava, HN; Gulati, A; Ramarao, P | 2 |
| Bhargava, HN; Ramarao, P | 1 |
| Garzon, J; Landahl, HD; Lee, NM | 1 |
| Rauch, RJ; Stephenson, JD; Stolerman, IP | 1 |
| Frey, EA; Jacobson, AE; Rice, KC; Tocque, B | 1 |
| De Souza, EB; Kuhar, MJ; Schmidt, WK | 1 |
| Imai, T; Kamikubo, K; Miura, K; Miura, Y; Miyashita, T; Murase, H; Nakamura, S; Niwa, M; Satoh, T; Tomita, A | 1 |
| Burks, TF; Fox, DA | 1 |
| Larson, DL; Lipkowski, AW; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Ishizuka, Y; Oka, T | 1 |
| Bertelli, GM; Borea, PA; Gilli, G | 1 |
| Cicero, TJ; Nock, B; O'Connor, LH; Rajpara, A | 1 |
| Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Dougall, IG; Leff, P | 1 |
| Dashwood, MR; Muddle, JR; Spyer, KM | 1 |
| Su, TP | 1 |
| Moises, HC; Walker, JM | 1 |
| Herz, A; Schiller, PW; Schulz, R; Shearman, GT | 1 |
| Bicknell, RJ; Chapman, C; Leng, G | 1 |
| Falke, NE; Fischer, EG; Martin, R | 1 |
| Illes, P; Ramme, D | 1 |
| Geppert, M; Illes, P; Jackisch, R | 1 |
| Buder, M; Fuder, H; Riers, HD; Rothacher, G | 1 |
| Brenner, AS; Geppert, M; Illes, P; Jackisch, R | 1 |
| Kirby, GC; McQueen, DS | 1 |
| Burks, TF; Deupree, D; Hruby, V; Hsiao, S; Mosberg, HI; Porreca, F; Spencer, RL | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Russell, NJ; Schaible, HG; Schmidt, RF | 1 |
| Benyhe, S; Borsodi, A; Hepp, J; Khan, A; Medzihradszky, K; Simon, J; Szücs, M; Wollemann, M | 1 |
| Belisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Lemaire, S; Petit, A | 1 |
| Cruciani, RA; Gainer, H; Lang, MA; Pesce, GO; Rodbard, D; Russell, JT | 1 |
| Alvinerie, M; Bueno, L; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Goodman, SR; McLaughlin, PJ; Zagon, IS | 1 |
| Coscia, CJ; Roth, BL; Spain, JW | 1 |
| Portoghese, PS; Takemori, AE | 2 |
| Boublik, J; Funder, JW; Jefferys, D | 1 |
| Hammonds, RG; Ho, CL; Li, CH | 1 |
| Ensinger, HA | 1 |
| Benyhe, S; Borsodi, A; Simon, J; Szücs, M; Wollemann, M | 1 |
| Neil, A | 2 |
| Brown, SR; Cox, BM; Werling, LL; Zarr, GD | 2 |
| Dewar, D; Jenner, P; Marsden, CD | 2 |
| Bunn, SJ; Hanley, MR; Wilkin, GP | 1 |
| Krall, S; Lynch, WC; Paden, CM; Watt, J | 1 |
| Boudouresque, F; Bourhim, N; Cantau, P; Castanas, E; Giraud, P; Oliver, C | 1 |
| Hirobe, M; Konno, F; Sato, Y; Takayanagi, I; Togashi, K | 1 |
| Bidlack, JM; Denton, RR | 1 |
| Bell, RD; Cicero, TJ | 1 |
| Bettermann, R; Illes, P | 1 |
| Itzhak, Y; Pasternak, GW | 1 |
| Glasel, JA; Myers, WE | 1 |
| Su, TP; Weissman, AD; Yeh, SY | 1 |
| Simon, EJ | 1 |
| Faden, AI; Krumins, SA | 1 |
| Brown, SR; Cote, TE; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Brown, SR; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Goldberg, S; Haertzen, C; Johnson, RE; Kumor, K; Su, TP; Vaupel, B | 1 |
| Liu-Chen, LY; Tam, SW | 1 |
| Bakalkin, GIa; Iarygin, KN; Kobylianskiĭ, AG; Nesterenko, PN; Pivovarov, AS | 1 |
| Bhargava, HN; Das, S | 2 |
| Gardner, EL; Vaysse, PJ; Zukin, RS | 1 |
| Portoghese, PS; Schoenecker, JW; Takemori, AE | 1 |
| Krumins, SA | 1 |
| Delay-Goyet, P; Roques, BP; Zajac, JM | 1 |
| Lovett, JA; Portoghese, PS | 1 |
| Bardon, T; Ruckebusch, Y | 1 |
| Bardon, T; Pairet, M; Ruckebusch, Y | 1 |
| Garzón, J; Lee, NM; Sánchez-Blázquez, P | 1 |
| Loh, HH; Stokes, KB | 1 |
| Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 1 |
| Dawson, G; McLawhon, RW; Miller, RJ; West, RE | 2 |
| Dickinson, SL; Slater, P | 1 |
| Chavkin, C; Goldstein, A; James, IF | 1 |
| Charleson, S; Wood, PL | 1 |
| Ben-Sreti, MM; Sewell, RD | 1 |
| Huidobro-Toro, JP; Lee, NM; Loh, HH; Way, EL; Yoshimura, K | 1 |
| Tung, AS; Yaksh, TL | 1 |
| Goodman, RR; Snyder, SH | 1 |
| Huidobro-Toro, JP; Way, EL; Yoshimura, K | 1 |
| Garzón, J; Jen, MF; Lee, NM | 1 |
| Herz, A | 1 |
| Fujibayashi, K; Iwama, T; Kubota, A; Satoh, M; Takagi, H; Wada, T; Yasui, M | 1 |
| Pairet, M; Ruckebusch, Y | 1 |
| Rezvani, A; Way, EL | 1 |
| Burkard, WP; Flück, N; Müller, PM | 1 |
| Livingston, A; Morris, B | 1 |
| Hylden, JL; Wilcox, GL | 1 |
| Pasternak, GW | 1 |
| Chang, KJ; Cuatrecasas, P; Hazum, E | 1 |
| Gähwiler, BH; Maurer, R | 1 |
| Kosterlitz, HW; Paterson, SJ; Robson, LE | 1 |
| Lajtha, A; Reith, ME; Sershen, H; Vadasz, C | 1 |
| Herz, A; Shearman, GT | 1 |
| Nishimura, S; Pasternak, GW; Wolozin, BL | 1 |
| Ishizuka, Y; Kajiwara, M; Matsumiya, T; Negishi, K; Oka, T; Watanabe, Y | 1 |
| Bajusz, S; Berzétei, IP; Hársing, LG; Rónai, AZ; Vizi, ES | 1 |
| Itzhak, Y; Keren, O; Sarne, Y | 1 |
| Nishimura, S; Pasternak, GW | 1 |
| Guidotti, A; Saiani, L | 1 |
| Bearden, LJ; Snead, OC | 1 |
| Takemori, AE; Ward, SJ | 1 |
| Attali, B; Audigier, Y; Cros, J; Gouardères, C; Mazarguil, H | 1 |
| Kandasamy, SB; Williams, BA | 1 |
| Johnson, N; Pasternak, GW | 1 |
| Tam, SW | 1 |
| Boublik, JH; Clements, JA; Funder, JW; Herington, AC | 1 |
| Killian, A; Mack, KJ; Weyhenmeyer, JA | 1 |
| Goldstein, A; Han, JS; Xie, GX | 1 |
| Chaillet, P; Costentin, J; Marçais-Collado, H | 1 |
| Isaacson, RL; Lanthorn, TH | 1 |
| McCarthy, PS; Sanger, DJ | 1 |
| Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Petit, A | 1 |
| Castanas, E; Gravanis, A; Hatzoglou, A; Margioris, AN; Zoumakis, E | 1 |
| Fukuda, K; Kato, S; Mori, K | 1 |
| Barnard, EA; Benyhe, S; Borsodi, A; Simon, J; Wollemann, M | 1 |
| Cotter, P; Deviche, P; Gulledge, CC | 1 |
| Bhargava, HN; Reddy, PL | 1 |
| Bakogeorgou, E; Castanas, E; Hatzoglou, A | 1 |
| Hanke, J; Jaros, PP; Willig, A | 1 |
| Castanas, E; Hatzoglou, A; Kampa, M; Loukas, S; Martin, P; Martin, PM | 1 |
| Akil, H; Fine, JL; Hoversten, MT; Mansour, A; Mosberg, HI; Taylor, LP; Thompson, RC; Watson, SJ | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Bakogeorgou, E; Castanas, E; Damianaki, A; Hatzoglou, A; Kampa, M; Martin, PM | 1 |
| Castanas, E; Denizot, A; Dermitzaki, I; Gravanis, A; Hatzoglou, A; Henry, JF; Kampa, M; Margioris, AN; Oliver, C | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
3 review(s) available for enkephalin, leucine and ethylketocyclazocine
| Article | Year |
|---|---|
Classification of opioid and 5-hydroxytryptamine receptors by means of discriminative drug effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Conditioning, Classical; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Lysergic Acid Diethylamide; Narcotics; Nicotine; Piperazines; Pyrimidines; Receptors, Opioid; Receptors, Serotonin; Research Design; Tetrahydronaphthalenes | 1987 |
Recent studies on opioid receptors: heterogeneity and purification.
Topics: Alcohols; Animals; Brain Chemistry; Centrifugation, Density Gradient; Chromatography, Affinity; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Ethylmaleimide; Humans; Lectins; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Solubility; Tritium; Wheat Germ Agglutinins | 1986 |
Multiple opiate receptors and their functional significance.
Topics: Animals; beta-Endorphin; Brain; Cyclazocine; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Morphine; Receptors, Opioid; Tissue Distribution | 1983 |
152 other study(ies) available for enkephalin, leucine and ethylketocyclazocine
| Article | Year |
|---|---|
Narcotic drug discriminations by rhesus monkeys and pigeons.
Topics: Animals; Columbidae; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalins; Ethylketocyclazocine; Etorphine; Hormones; Macaca; Macaca mulatta; Naltrexone; Narcotics; Phenazocine | 1979 |
Kappa opioid agonists inhibit transmitter release from guinea pig hippocampal mossy fiber synaptosomes.
Topics: Animals; Azocines; Calcium; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Male; Potassium; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptosomes | 1992 |
Autoradiographic distribution of mu, delta and kappa opioid binding sites in the superficial dorsal horn, over the rostrocaudal axis of the rat spinal cord.
Topics: Animals; Autoradiography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Kinetics; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Tritium | 1991 |
[Evaluation of the discriminative stimulus effect of an enkephalin analog, EK-399, in the rat].
Topics: Animals; Discrimination, Psychological; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
The effect of morphine tolerance-dependence and abstinence on mu, delta, and kappa opiate receptors of discrete brain regions and spinal cord of the rat.
Topics: Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 1990 |
Modulation of mu, kappa and delta opioid receptors in the rat brain by isoflurane and enflurane.
Topics: Analgesics; Animals; Brain Chemistry; Cerebral Cortex; Enflurane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Isoflurane; Male; Mesencephalon; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Synergistic analgesic interactions between the periaqueductal gray and the locus coeruleus.
Topics: Analgesics; Animals; Enkephalin, Leucine; Ethylketocyclazocine; Locus Coeruleus; Male; Microinjections; Morphine; Narcotic Antagonists; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reticular Formation; Stereotaxic Techniques | 1991 |
Anterograde transport of opioid receptors in rat vagus nerves and dorsal roots of spinal nerves: pharmacology and sensitivity to sodium and guanine nucleotides.
Topics: Animals; Axonal Transport; Colchicine; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guanosine Triphosphate; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride; Spinal Nerve Roots; Vagus Nerve | 1990 |
Differential effects of neuropeptide Y and opioids on neurogenic responses of the perfused rat mesentery.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Guanethidine; In Vitro Techniques; Male; Methoxamine; Muscle, Smooth, Vascular; Narcotics; Neuropeptide Y; Rats; Rats, Inbred Strains; Splanchnic Circulation; Vasoconstriction; Vasodilation | 1991 |
The occurrence of different kappa opioid receptors (K1 and K2) in frog (Rana esculenta) brain membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ligands; Morphinans; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Kappa opioid receptors stimulate phosphoinositide turnover in rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Dynorphins; Enkephalins; Ethylketocyclazocine; Male; Phosphatidylinositols; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses.
Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1990 |
Modulation of mu, delta and kappa opioid receptors in rat brain by metal ions and histidine.
Topics: Animals; Brain Chemistry; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Histidine; Kinetics; Male; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfhydryl Reagents; Trace Elements; Zinc | 1990 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
Demonstration of the heterogeneity of the kappa-opioid receptors in guinea-pig cerebellum using selective and nonselective drugs.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cerebellum; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Pre- and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1990 |
Inhibition of neuronally induced relaxation of canine lower esophageal sphincter by opioid peptides.
Topics: Animals; Autonomic Nervous System; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dogs; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Esophagogastric Junction; Ethylketocyclazocine; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Neurons; Phenazocine | 1990 |
Selective inhibitory effects of ethylketocyclazocine on reflex pathways to the external urethral sphincter of the cat.
Topics: Animals; Cats; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Urethra; Urinary Bladder; Urinary Incontinence | 1989 |
Characterization of high affinity opioid binding sites in rat periaqueductal gray P2 membrane.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Membranes; Periaqueductal Gray; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Central and peripheral opioid modulation of gastric relaxation induced by feeding in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Dogs; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Morphine; Muscle Relaxation; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagotomy; Vagus Nerve | 1989 |
Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin.
Topics: Animals; Brain Chemistry; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Guinea Pigs; Hemoglobins; In Vitro Techniques; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Changes in multiple opioid receptors in regions of the brain in rats treated chronically with thyroxine.
Topics: Animals; Blood Pressure; Body Weight; Brain; Chromatography, High Pressure Liquid; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Heart Rate; Hyperthyroidism; Male; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Thyroxine | 1989 |
Antagonism of kappa opioid mediated effects in the rat by cyclo(Leu-Gly).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Cortex; Cyclazocine; Diuresis; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Neuropeptides; Peptides, Cyclic; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1989 |
Computer analysis of the effect of beta-endorphin and dynorphin and related compounds on opioid binding to mouse brain membrane.
Topics: Animals; beta-Endorphin; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Mice; Models, Neurological; Receptors, Opioid | 1989 |
The mu-opioid receptor in the 7315c tumor cell.
Topics: Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1987 |
Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic.
Topics: Analgesia; Animals; Autoradiography; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Haplorhini; Male; Morphinans; Nalbuphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1988 |
Varying expression of opioid receptors and GTP-binding proteins in human pheochromocytomas.
Topics: Adrenal Gland Neoplasms; beta-Endorphin; Cell Membrane; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; GTP-Binding Proteins; Humans; Pheochromocytoma; Receptors, Opioid | 1986 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Molecular; Morphine; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 1988 |
Relation of diltiazem binding sites to opioid receptor subtypes in the guinea-pig brain.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Diltiazem; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Naloxone; Radioligand Assay; Receptors, Opioid | 1987 |
Temperature dependence of the binding of mu, delta and kappa agonists to the opiate receptors in guinea-pig brain.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Temperature | 1988 |
[3H]U-69593 labels a subtype of kappa opiate receptor with characteristics different from that labeled by [3H]ethylketocyclazocine.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride; Temperature; Tritium | 1988 |
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Estimation of opioid receptor agonist dissociation constants with beta-chlornaltrexamine, an irreversible ligand which also displays agonism.
Topics: Animals; Cyclazocine; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Opiate receptor subtypes in the nucleus tractus solitarii of the cat: the effect of vagal section.
Topics: Animals; Autoradiography; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Female; Male; Medulla Oblongata; Naloxone; Receptors, Opioid; Vagotomy | 1988 |
Effect of methimazole-induced hypothyroidism on multiple opioid receptors in rat brain regions.
Topics: Animals; Body Temperature; Body Weight; Brain Chemistry; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Heart Rate; Hypothyroidism; Male; Methimazole; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Triiodothyronine | 1988 |
Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Binding Sites; Brain; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Levallorphan; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1985 |
Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat.
Topics: Animals; Cyclazocine; Dynorphins; Electrophysiology; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; gamma-Aminobutyric Acid; Hippocampus; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Generalization tests with intraventricularly applied pro-enkephalin B-derived peptides in rats trained to discriminate the opioid kappa receptor agonist ethylketocyclazocine.
Topics: Animals; beta-Endorphin; Cyclazocine; Discrimination Learning; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Generalization, Stimulus; Injections, Intraventricular; Male; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Effects of opioid agonists and antagonists on oxytocin and vasopressin release in vitro.
Topics: Animals; Arginine Vasopressin; Benzomorphans; beta-Endorphin; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains | 1985 |
Stereospecific opiate binding in living human polymorphonuclear leucocytes.
Topics: Analgesics, Opioid; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Granulocytes; Humans; Kinetics; Naloxone; Neutrophils; Receptors, Opioid | 1985 |
Differential effect of stimulation strength in mouse vas deferens on inhibition of neuroeffector transmission by receptor type selective opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cyclazocine; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Morphine Derivatives; Muscle, Smooth; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Synaptic Transmission | 1986 |
Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit.
Topics: Animals; Benzomorphans; Clonidine; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hippocampus; Morphine; Norepinephrine; Rabbits; Receptors, Opioid | 1986 |
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Presynaptic opioid receptors modulating acetylcholine release in the hippocampus of the rabbit.
Topics: Acetylcholine; Animals; Benzomorphans; Choline; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Naloxone; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hypercapnia; Hypoxia; Peptide Fragments; Receptors, Opioid | 1986 |
Centrally-administered opioid selective agonists inhibit drinking in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Drinking Behavior; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Haloperidol; Histamine; Histidine Decarboxylase; Ketamine; Male; Methylhistidines; Mice; Naloxone; Pargyline; Phenazocine; Phencyclidine; Receptors, Opioid | 1987 |
Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Arthritis; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Morphine; Naloxone; Nociceptors; Pain; Peripheral Nerves; Pyrrolidines | 1987 |
Purification of a kappa-opioid receptor subtype from frog brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Chromatography, Gel; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Membranes; Molecular Weight; Naloxone; Peptide Fragments; Pyrrolidines; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa; Solubility | 1987 |
Functional opioid receptor sites in human placentas.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gonadotropin-Releasing Hormone; Humans; Kinetics; Placenta; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thyrotropin-Releasing Hormone | 1988 |
Opioid receptors of bovine posterior pituitary neurosecretosomes are exclusively kappa.
Topics: Analgesics, Opioid; Animals; Cattle; Cyclazocine; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Kinetics; Morphinans; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
CNS blockade of acoustic stress-induced gastric motor inhibition by kappa-opiate agonists in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Adrenocorticotropic Hormone; Analgesics; Animals; Cyclazocine; Dogs; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gastrointestinal Motility; Hydrocortisone; Pyrrolidines; Stress, Physiological | 1988 |
Characterization of opioid binding sites in murine neuroblastoma.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Clone Cells; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Kinetics; Ligands; Mice; Neuroblastoma; Receptors, Opioid | 1988 |
Differential ontogeny of multiple opioid receptors (mu, delta, and kappa).
Topics: Animals; Animals, Newborn; Brain; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1985 |
TENA, a selective kappa opioid receptor antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
A kappa-selective opioidergic pathway is involved in the reversal of a behavioural effect of adrenalectomy.
Topics: Adrenalectomy; Animals; Benzomorphans; Cyclazocine; Enkephalins; Ethylketocyclazocine; Immobilization; Male; Memory; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Opiate receptor binding profile in the rabbit cerebellum and brain membranes.
Topics: Animals; beta-Endorphin; Binding Sites; Binding, Competitive; Brain; Cerebellum; Cold Temperature; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Rabbits; Receptors, Opioid; Sodium; Tritium | 1985 |
Differentiating aspects of opioid receptor binding by [3H](-) (1R,5R,9R,2''S)-5,9-dimethyl-2-tetrahydrofurfuryl-2'-hydroxy-6,7- benzomorphan hydrochloride ([3H]Mr 2034), a drug preferentially acting on kappa-receptors.
Topics: Animals; Benzomorphans; Binding, Competitive; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Separation of kappa-opioid receptor subtype from frog brain.
Topics: Animals; Brain Chemistry; Centrifugation, Density Gradient; Chromatography, Gel; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Detection and characterization of four binding sites for opioids in the mouse brain.
Topics: Animals; Binding Sites; Brain Chemistry; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Models, Biological; Naloxone; Receptors, Opioid; Software; Tritium | 1985 |
Opioid binding to rat and guinea-pig neural membranes in the presence of physiological cations at 37 degrees C.
Topics: Animals; Brain; Cations; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Male; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Temperature; Tritium | 1985 |
Behavioural effects in rats of unilateral and bilateral injections of opiate receptor agonists into the globus pallidus.
Topics: Animals; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Globus Pallidus; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Evidence for a kappa-opioid receptor on pituitary astrocytes: an autoradiographic study.
Topics: Animals; Astrocytes; Autoradiography; Binding Sites; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Pituitary Gland; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Corpus Striatum; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Feeding Behavior; Limbic System; Male; Morphine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Taste | 1985 |
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: II. Interaction with kappa sites.
Topics: Adrenal Medulla; Animals; Benzomorphans; Binding Sites; Calcium; Cattle; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Ethylmaleimide; Etorphine; Guinea Pigs; Kinetics; Lithium; Manganese; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, kappa; Sodium; Stereoisomerism | 1985 |
Interactions of codeine-7,8-oxide (codeine-epoxide), as a new metabolite of codeine, with multiple opiate receptors.
Topics: Animals; Brain; Cell Membrane; Codeine; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guanosine Triphosphate; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride | 1985 |
A monoclonal antibody capable of modulating opioid binding to rat neural membranes.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cyclazocine; Dihydromorphine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Flunitrazepam; Immunoglobulin M; Kinetics; Male; Mice; Mice, Inbred BALB C; Molecular Weight; Naloxone; Narcotics; Nerve Tissue; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
A radiolabeled-ligand-binding technique for the characterization of opioid receptors in the intact mouse vas deferens.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Mice; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid; Vas Deferens | 1985 |
Classification of presynaptic opioid receptors in the rabbit ear artery by competitive antagonists.
Topics: Animals; Arteries; Benzomorphans; Binding, Competitive; Biological Assay; Cyclazocine; Ear; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Naloxone; Rabbits; Receptors, Opioid; Synaptic Membranes | 1986 |
Kappa-opiate binding to rat brain and guinea pig cerebellum: sensitivity towards ions and nucleotides.
Topics: Animals; Brain; Cerebellum; Cyclazocine; Electrolytes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guanine Nucleotides; Guinea Pigs; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Subclass specificity of anti-idiotypic anti-opiate receptor antibodies in rat brain, guinea pig cerebellum, & neuroblastoma x glioma (NG 108-15).
Topics: Animals; Antibodies, Anti-Idiotypic; Binding, Competitive; Cell Line; Cerebellum; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Morphine; Neurilemma; Neurons; Rats; Receptors, Opioid | 1986 |
Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): evidence from binding assays.
Topics: Animals; Binding, Competitive; Brain; Chromatography, Gel; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Kinetics; Male; Naloxone; Phenazocine; Phencyclidine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Traumatic injury alters opiate receptor binding in rat spinal cord.
Topics: Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Spinal Cord Injuries | 1986 |
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1986 |
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Guinea Pigs; Male; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1986 |
Opioid ligand binding sites in the spinal cord of the guinea-pig.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1986 |
Studies of kappa agonist.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Humans; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
[Differences in opioid binding in the left and right visual cortex of the turtle].
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Functional Laterality; Receptors, Opioid; Turtles; Visual Cortex | 1986 |
Selective proliferation of brain kappa opiate receptors in spontaneously hypertensive rats.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; Kinetics; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Unidirectional interaction between thyrotropin releasing hormone and opiates at the level of their brain receptors.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; Male; Naltrexone; Oligopeptides; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Thyrotropin-Releasing Hormone | 1987 |
Modulation of rat brain opioid receptors by cannabinoids.
Topics: Animals; Cannabinoids; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spiperone | 1987 |
Nonequilibrium opioid antagonist activity of 6,14-dideoxynaltrexone derivatives.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Opioid receptor binding in rat spinal cord.
Topics: Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1987 |
Differences of binding characteristics of non-selective opiates towards mu and delta receptor types.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebellum; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Oligopeptides; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Synthesis and evaluation of melphalan-containing N,N-dialkylenkephalin analogues as irreversible antagonists of the delta opioid receptor.
Topics: Alkylation; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Melphalan; Mice; Morphine; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1987 |
Effects of opioid agonist drugs on the in vitro release of 3H-GABA, 3H-dopamine and 3H-5HT from slices of rat globus pallidus.
Topics: Animals; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; gamma-Aminobutyric Acid; Globus Pallidus; Potassium Chloride; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Comparative effects of opiate agonists on proximal and distal colonic motility in dogs.
Topics: Animals; Colon; Cyclazocine; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Injections, Intravenous; Injections, Spinal; Narcotics; Time Factors | 1985 |
Opioid control of the ruminant stomach motility: functional importance of mu, kappa and delta receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep; Stomach | 1984 |
[3H]Ethylketocyclazocine binding to mouse brain membranes: evidence for a kappa opioid receptor type.
Topics: Animals; Brain; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1984 |
Altered opiate receptor binding in synaptosomes: implication of phosphorylation.
Topics: Animals; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Phosphorylation; Receptors, Opioid; Synaptosomes | 1984 |
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Radioligands for probing opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1984 |
Distinct high-affinity binding sites for benzomorphan drugs and enkephalin in a neuroblastoma--brain hybrid cell line.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cell Line; Cyclazocine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hybrid Cells; Kinetics; Morphinans; Neuroblastoma; Phenazocine; Rats; Receptors, Opioid | 1981 |
Opiate receptor antagonism by L-prolyl-L-leucyl-glycinamide, MIF-I.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Female; Ileum; In Vitro Techniques; Male; Mice; Morphine; Motor Activity; MSH Release-Inhibiting Hormone; Muscle Contraction; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens | 1980 |
Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Ligands; Morphine Derivatives; Myenteric Plexus; Naloxone; Peptide Fragments; Receptors, Opioid | 1982 |
High affinity [3H]ethylketazocine binding: evidence for specific kappa receptors.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Rats; Receptors, Opioid; Tritium | 1982 |
Stereospecific inhibition of oxotremorine-induced antinociception by (+)-isomers of opioid antagonists: comparison with opioid receptor agonists.
Topics: Animals; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Mice; Morphine; Narcotic Antagonists; Nociceptors; Oxotremorine; Receptors, Opioid; Stereoisomerism | 1982 |
Activation of K-opiate sites by dynorphin in the myenteric plexus.
Topics: Animals; Cyclazocine; Drug Tolerance; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa | 1982 |
In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Injections, Spinal; Male; Naloxone; Pain; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1982 |
Kappa opiate receptors localized by autoradiography to deep layers of cerebral cortex: relation to sedative effects.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Benzomorphans; Brain Stem; Cerebral Cortex; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Morphine; Organ Specificity; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1982 |
Potency of three opiate antagonists to reverse the inhibitory activity of dynorphin, enkephalins and opioid-like alkaloids on the guinea pig ileum.
Topics: Animals; Azocines; Benzomorphans; Cyclazocine; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Muscle, Smooth; Naloxone; Narcotic Antagonists | 1982 |
Differential modification of opiate receptor activity by arylsulfatase treatment.
Topics: Analgesia; Analgesics, Opioid; Animals; Arylsulfatases; beta-Endorphin; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Antagonism; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hormones; Kinetics; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Sulfatases | 1983 |
Comparison of analgesic potencies of mu, delta and kappa agonists locally applied to various CNS regions relevant to analgesia in rats.
Topics: Analgesics, Opioid; Animals; Brain Stem; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Cyclazocine; Dynorphins; Electric Conductivity; Enkephalins; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Dynorphin-(1-13) restores the potency of morphine on the tolerant guinea pig ileum.
Topics: Animals; beta-Endorphin; Cyclazocine; Drug Interactions; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments | 1984 |
Affinities of some common opioid analgesics towards four binding sites in mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding Sites; Brain; Codeine; Cyclazocine; Dextropropoxyphene; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Methionine; Ethylketocyclazocine; In Vitro Techniques; Membranes; Methadone; Mice; Models, Biological; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Characteristics of 3H-tifluadom binding in guinea-pig brain membranes.
Topics: Animals; Benzodiazepines; Benzomorphans; Binding Sites; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Morphine; Receptors, Opioid | 1984 |
Binding of [3H]clonidine to membranes from cow neurohypophysis and cerebral cortex of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Cerebral Cortex; Clonidine; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Membranes; Morphine; Naloxone; Narcotics; Pituitary Gland, Posterior; Rats | 1984 |
Intrathecal opioids block a spinal action of substance P in mice: functional importance of both mu- and delta-receptors.
Topics: Animals; Cyclazocine; Enkephalins; Ethylketocyclazocine; Injections, Spinal; Male; Mice; Morphine; Narcotics; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Synaptic Transmission | 1982 |
Multiple opiate receptors: [3H]ethylketocyclazocine receptor binding and ketocyclazocine analgesia.
Topics: Analgesics; Animals; Brain; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Mice; Morphine; Motor Activity; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1980 |
Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Diprenorphine; Endorphins; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Morphinans; Morphine; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Synaptic Membranes | 1980 |
Involvement of mu-receptors in the opioid-induced generation of bursting discharges in hippocampal pyramidal cells.
Topics: Animals; Benzomorphans; Culture Techniques; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Electrophysiology; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Membrane Potentials; Morphinans; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1981 |
Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.
Topics: Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Naloxone; Naltrexone; Narcotics; Phenoxybenzamine; Receptors, Opioid | 1981 |
Strain differences in opiate receptors in mouse brain.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naloxone; Receptors, Opioid; Species Specificity | 1981 |
D-Ala2,D-Leu5-enkephalin generalizes to a discriminative stimulus produced by fentanyl but not ethylketocyclazocine.
Topics: Animals; Cyclazocine; Discrimination, Psychological; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Fentanyl; Generalization, Stimulus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
The binding of kappa- and sigma-opiates in rat brain.
Topics: Animals; Binding Sites; Brain; Culture Techniques; Cyclazocine; Dihydromorphine; Enkephalins; Ethylketocyclazocine; Ligands; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Tritium | 1982 |
The choice of opiate receptor subtype by neo-endorphins.
Topics: Animals; Benzomorphans; beta-Endorphin; Cyclazocine; Drug Interactions; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid | 1982 |
[Met5]enkephalin-Arg-Phe ACTS on vascular opiate receptors.
Topics: Animals; Cyclazocine; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Receptors, Opioid | 1982 |
Differential effect of humoral endorphin on the binding of opiate agonists and antagonists.
Topics: Animals; Binding Sites; Binding, Competitive; Cyclazocine; Endorphins; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Opioid; Sodium | 1982 |
Opiate and opioid peptide binding in rat goldfish: further evidence for opiate receptor heterogeneity.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Goldfish; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1982 |
Opiate receptor-mediated inhibition of catecholamine release in primary cultures of bovine adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; beta-Endorphin; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Phenazocine; Receptors, Opioid | 1982 |
The epileptogenic spectrum of opiate agonists.
Topics: Animals; Anticonvulsants; beta-Endorphin; Cyclazocine; Electroencephalography; Endorphins; Enkephalin, Leucine; Epilepsy; Ethylketocyclazocine; Injections, Intraventricular; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains | 1982 |
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid | 1983 |
Evidence for multiple "Kappa" binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord.
Topics: Animals; Binding Sites; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1982 |
Peptide and non-peptide opioid-induced hyperthermia in rabbits.
Topics: Animals; beta-Endorphin; Body Temperature; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptides; Phenazocine; Rats | 1983 |
The binding to rat brain homogenates of Mr2034, a universal opiate.
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphinans; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Naloxone-inaccessible sigma receptor in rat central nervous system.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalins; Ethylketocyclazocine; Kinetics; Naloxone; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord; Tissue Distribution | 1983 |
Opiate binding sites in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Binding Sites; Brain; Brain Chemistry; Cattle; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Ligands; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Comparison of mu, delta, and kappa opiate binding sites in rat brain and spinal cord.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1984 |
[3H]ethylketocyclazocine binding to NCB-20 hybrid neurotumor cells.
Topics: Animals; Binding, Competitive; Brain; Cricetinae; Cricetulus; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Hybrid Cells; Kinetics; Neuroblastoma; Trypsin | 1983 |
Analgesia induced by intrathecal injection of dynorphin B in the rat.
Topics: Analgesics; Animals; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Female; Injections, Spinal; Morphine; Naloxone; Rats | 1984 |
Catatonic or hypotonic immobility induced in mice by intracerebroventricular injection of mu or kappa opioid receptor agonists as well as enkephalins or inhibitors of their degradation.
Topics: Animals; Benzomorphans; Catatonia; Cyclazocine; Enkephalins; Ethylketocyclazocine; Fentanyl; Humans; Immobilization; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics | 1983 |
Hippocampal involvement in the pharmacologic induction of withdrawal-like behaviors.
Topics: Animals; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Escape Reaction; Ethylketocyclazocine; Hippocampus; Humans; Injections, Intraventricular; Kainic Acid; Morphine Dependence; Pyrrolidines; Rats; Serotonin; Shivering; Substance Withdrawal Syndrome; Valproic Acid | 1981 |
Increased food and water intake produced in rats by opiate receptor agonists.
Topics: Animals; Cyclazocine; Drinking; Drug Interactions; Eating; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Narcotics; Rats | 1981 |
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella | 1993 |
Identification and characterization of opioid-binding sites present in the Ishikawa human endometrial adenocarcinoma cell line.
Topics: Acids; Adenocarcinoma; Binding Sites; Endometrial Neoplasms; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Humans; Narcotics; Tumor Cells, Cultured | 1995 |
Location of regions of the opioid receptor involved in selective agonist binding.
Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Narcotics; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins | 1995 |
[3H]dynorphin1-8 binding sites in frog (Rana esculenta) brain membranes.
Topics: Amino Acid Sequence; Animals; Brain; Cell Membrane; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Naloxone; Peptide Fragments; Rana esculenta; Receptors, Opioid; Sodium Chloride; Tritium | 1994 |
Identification, partial characterization, and hypothalamic distribution of kappa, mu, and delta opioid receptors in a passerine songbird (Junco hyemalis).
Topics: Animals; Autoradiography; Binding, Competitive; Birds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Feeding Behavior; Hypothalamic Area, Lateral; Hypothalamus; In Vitro Techniques; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thermodynamics; Ventromedial Hypothalamic Nucleus | 1993 |
Effect of low pH treatment on opioid peptides binding to their receptors and functional coupling of G-proteins to adenylyl cyclase in the rat spinal cord.
Topics: Adenylyl Cyclases; Analgesics; Animals; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; GTP-Binding Proteins; Hydrogen-Ion Concentration; Kinetics; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Fluoride; Spinal Cord | 1996 |
The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors.
Topics: Adenocarcinoma; Amino Acid Sequence; Binding Sites; Breast Neoplasms; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Opioid Peptides; Receptors, Opioid; Tumor Cells, Cultured | 1996 |
Opioid receptor types for endogenous enkephalin in the thoracic ganglion of the crab, Carcinus maenas.
Topics: Analgesics, Opioid; Animals; Brachyura; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Ganglia; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide).
Topics: Amino Acid Sequence; Binding, Competitive; Breast Neoplasms; Caseins; Cell Division; Cell Line; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Humans; Kinetics; Peptide Fragments; Receptors, Opioid, kappa | 1996 |
Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study.
Topics: Animals; Binding, Competitive; COS Cells; Drug Residues; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Immunohistochemistry; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Rats; Receptors, Opioid, mu | 1997 |
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum.
Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Opioid alkaloids and casomorphin peptides decrease the proliferation of prostatic cancer cell lines (LNCaP, PC3 and DU145) through a partial interaction with opioid receptors.
Topics: Binding Sites; Caseins; Cell Division; Cell Survival; Enkephalins; Ethylketocyclazocine; Humans; Ligands; Male; Morphinans; Narcotic Antagonists; Narcotics; Prostatic Neoplasms; Receptors, Opioid; Tumor Cells, Cultured | 1997 |
Kappa1-opioid binding sites are the dominant opioid binding sites in surgical specimens of human pheochromocytomas and in a human pheochromocytoma (KAT45) cell line.
Topics: Analgesics, Opioid; Binding Sites; Binding, Competitive; Catecholamines; Cell Membrane; Diprenorphine; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epinephrine; Ethylketocyclazocine; Humans; Narcotic Antagonists; Norepinephrine; Opioid Peptides; Pheochromocytoma; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium; Tumor Cells, Cultured | 1999 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |