enkephalin, leucine has been researched along with enkephalin-leu, ala(2)-arg(6)- in 128 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 90 (70.31) | 18.7374 |
1990's | 32 (25.00) | 18.2507 |
2000's | 5 (3.91) | 29.6817 |
2010's | 1 (0.78) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Afanas'ev, SA; Kravchenko, AI; Lishmanov, IuB; Rebrova, TIu | 1 |
Khugaeva, VK | 3 |
Barbarash, NA; Khaliulin, IG; Lishmanov, IuB; Maslov, LN | 1 |
Kalenchuk, VU; Kozlova, MV | 1 |
Gressler, Iu; Slepushkin, VD | 1 |
Lishmanov, IuB; Maslov, LN | 1 |
Izykenova, GA; Taranova, NP | 1 |
Belcheva, S; Kosteljanetz, N; Kupenova, P; Popova, E; Vitanova, L | 1 |
Donich, SG; Grebenchikov, OA; Karelin, AA; Korotkina, RN; Shloznikov, BM; Sitnikov, AV | 1 |
Likhvantsev, VM; Shloznikov, BM; Titov, MI; Vinogradov, AV | 1 |
Donich, SG; Fomchenkov, EP; Grebenchikova, OA; Kuznetsov, AIu; Likhvantsev, VV; Makhmutov, RF; Peretrukin, AI; Shloznikov, BM | 1 |
Lasukova, TV | 1 |
Didenko, VA; Dudko, VA; Fedorova, NA; Zoloev, GK | 1 |
Bulgakov, SA; Fedenko, VV; Fomin, VB; Georgadze, AK | 1 |
Golikov, AP; Riabinin, VA | 1 |
Berezhnova, NI; Shvets, SI; Timoshin, SS | 1 |
Afonskaia, NI; Anikin, AIu; Kargina-Terent'eva, RA | 1 |
Bikmulina, FS; Fomchenko, EP; Petrov, OV; Shloznikov, BM; Smol'nikov, PV; Vinogradov, VL | 1 |
Andreev, AI; Grebenchikov, OA; Karelin, AA; Kuzin, MI; Likhvantsev, BV; Shloznikov, BM; Sitnikov, AV; Tverskoĭ, AL | 1 |
Anisimov, VN; Bortkevich, SM | 1 |
Bulgakov, SA; Shcherbakova, NV; Smagin, VG; Vinogradov, VA; Zverkov, IV | 1 |
Istranov, LP; Khulup, GIa; Medvedev, OS; Spevak, SE; Titov, MI | 1 |
Filippovich, IuB; Fomina, GG; Lapteva, TI; Mikodona, EV | 1 |
Fedotova, TV; Lishmanov, IuB; Titov, MI | 1 |
Bogdanov, AN; Iarygin, KN; Pavlov, SA; Shugurov, VA; Vinogradov, VA | 1 |
Aleksandrovich, AG; Timoshin, SS; Uchakina, RV; Zhdanova, TF | 1 |
Gordeev, VF; Grigorevskiĭ, VP; Pashutin, SB; Priĭmak, SA; Satrapinskiĭ, VIu; Shatalov, VN; Vinogradov, VA | 1 |
Bocharova, VS; Botsmanov, KV; Grigorevskiĭ, VP; Tsvirkun, VV | 1 |
Adrian, K; Buntrock, P; Diezel, W; Kohl, A; Titov, MI; Werner, A | 1 |
Dvortsin, GF | 1 |
Grigorevskiĭ, VP; Karelin, AA; Korotkina, RN | 1 |
Argintaev, ES; Prum, IA; Slepushkin, VD; Sokolovich, GE; Zoloev, GK | 1 |
Pashutin, SB | 1 |
Grigorevskiĭ, VP; Karelin, AA; Korotkina, RN; Pomelov, VS; Shloznikov, BM | 1 |
Buiavykh, AG; Ezhov, VA | 1 |
Poiarkov, VD; Savitskiĭ, GG; Slepushkin, VD; Sokolovich, GE; Zoloev, GK | 1 |
Dygaĭ, AM; Gol'dberg, ED; Shakhov, VP; Zakharova, OIu | 1 |
Arefolov, VA; Khaĭsman, EB; Malikova, LA | 1 |
Bilibin, DP; Shevelev, OA | 1 |
Arndt, IP; Shcherbakova, NV; Smagin, VG; Zverkov, IV | 1 |
Akoev, GN; Il'inskiì, OB; Kolosova, LI; Titov, MI; Trofimova, OG | 1 |
Timoshin, SS; Zhdanova, TF | 1 |
Chikin, AV; Khamitov, KhS; Poletaev, GI; Urazaev, AKh; Volkov, EM | 1 |
Lishmanov, IuB; Maslov, LN; Titov, MI | 1 |
Bespalova, ZhD; Titov, MI; Vinogradov, VA | 1 |
Zoloev, GK | 3 |
Bobkov, AI; Demina, DG; Polonskiĭ, VM; Smagin, VG; Vinogradov, VA | 1 |
Korobov, NV; Polonskiĭ, VM | 1 |
Bespalova, ZhD; Isakova, OL; Ruuge, EK; Sakharov, IIu; Sepetov, NF | 1 |
Iarygin, KN; Krivosheev, OG; Moskovkin, GN; Polonskiĭ, VM; Vinogradov, VA | 1 |
Iarygin, KN; Korobov, NV; Solov'eva, AI; Spevak, SE; Vinogradov, VA | 1 |
Polonskiĭ, VM; Vinogradov, VA | 2 |
Buglak, NP; Vinogradov, VA | 1 |
Khlystov, VV; Lisachenko, GV; Pavlenko, VS; Slepushkin, VD; Usynin, AF | 1 |
Ananyeva, NM; Bespalova, JD; Pekelis, BL; Rokhlin, OV; Tischenko, VA; Titov, MI; Vinogradov, VA; Yakubov, LZ | 1 |
Shekhter, AB; Solov'eva, AI; Spevak, SE; Titov, MI | 1 |
Forner, K; Grosse, G; Jentzsch, KD; Lindner, G; Oehme, P; Wenzel, M | 1 |
Babkina, NV; Karelin, AA; Korotkina, RN; Kuzin, MI; Shloznikov, BM | 1 |
Dzhumbaev, SU; Egamov, IuS; Polonskiĭ, VM; Vinogradov, VA | 1 |
Bogdanov, AN; Bogdanov, NN; Buglak, NP; Lukash, SN; Vinogradov, VA | 1 |
Bulgakov, SA; El'bov, PV; Vinogradov, VA | 1 |
Khlystov, VV; Pavlenko, VS; Slepushkin, VD; Usynin, AF | 1 |
Aleksandrova, EN; Nasonov, EL; Titov, MI; Vinogradov, VA | 1 |
Aleĭnik, VA; Gerasimov, NF; Kurzanov, AN; Titova, GP; Vinogradov, VA | 1 |
Gabrielian, NA; Kanaian, AS; Permiakov, NK; Titova, GP; Voskanian, LO | 1 |
Dygaĭ, AM; Gol'dberg, ED; Zakharova, OIu | 1 |
Kalenikova, EI; Sokolov, AS; Vinogradov, VA | 1 |
Pan'kova, TD; Radivoz, MI; Timoshin, SS; Titov, MI | 1 |
Aĭrapetiants, MG; Kolomeĭtseva, IA; Levina, OL; Nozdracheva, LV | 1 |
Adigamov, MM; Beliaeva, VV; Belkin, AI; Moskovichiute, LI | 1 |
Afonin, BV; Drozd, IuV; Iasnetsov, VV; Karsanova, SK; Shashkov, VS | 1 |
Bulgakov, SA; Propisnova, EP; Smagin, VG; Titov, MI | 1 |
Bulgakov, SA; Propisnova, EP; Smagin, VG; Titov, MI; Vinogradov, VA | 1 |
Slepushkin, VD; Titov, MI; Vasil'tsev, IaS; Zoloev, GK | 1 |
Beĭko, VA; Karpov, RS; Vasil'chenko, EM | 1 |
Pan'kova, TD; Timoshin, SS; Titov, MI | 1 |
Arabadzhian, KP; Golovleva, GM; Kanaian, AS; Permiakov, NK; Titova, GP | 1 |
Fedotova, TV; Lishmanov, IuB; Mirza, VG; Slepushkin, VD; Zoloev, GK | 1 |
Il'inskiĭ, OB; Kalenchuk, VU; Kondrikova, ES; Kozlova, MV; Titov, MI | 1 |
Akhmetshina, AG; Slepushkin, VD; Zoloev, GK | 1 |
Dmitrieva, OF; Ivanikov, IO; Sergeeva, MG; Vinogradov, VA; Zaĭtsev, SV | 1 |
Iarygin, KN; Khokhlov, AP; Shitin, AG | 1 |
Gutsol, AA; Kondrat'ev, BIu | 1 |
Bobkov, AI; Semenova, VV | 1 |
Argintaev, ES; Slepushkin, VD; Zoloev, GK | 1 |
El'bov, PV | 1 |
Tepliuk, SG | 1 |
Dmitrieva, OF; Sokolov, AS; Tishchenko, VA | 1 |
Bogdanov, AN; Bulgakov, SA; Ovtrakht, N; Pavlov, SA | 1 |
Aleĭnik, VA; Kurzanov, AN; Vinogradov, VA | 1 |
Iarygin, KN; Moskovkin, GN; Polonskiĭ, VM; Shitin, AG | 1 |
Shekhter, AB; Solov'eva, AI; Spevak, SE | 1 |
Bespalova, ZhD; Dmitrieva, OF; Sergeeva, MG; Zaĭtsev, SV | 1 |
Isakova, OL; Pekelis, BL; Sepetov, NF; Suraeva, NM | 1 |
Afonskaia, NI; Cherpachenko, NM; Il'inskiĭ, OB; Kondalenko, VF; Spevak, SE | 1 |
Iarygin, KN; Polonskiĭ, VM; Shitin, AG; Vinogradov, VA | 1 |
Bespalova, ZhD; Bushuev, VN; Isakova, OL; Sepetov, NF; Vinogradov, VA | 1 |
Slepushkin, VD; Zoloev, GK | 1 |
Alekminskaia, LA; Lishmanov, IuB; Slepushkin, VD; Titov, MI | 1 |
Slepushkin, VD; Titov, MI; Zoloev, GK | 1 |
Lishmanov, IuB; Pavlenko, VS; Slepushkin, VD; Titov, MI; Zoloev, GK | 1 |
Lishmanov, IuB; Slepushkin, VD; Zoloev, GK | 1 |
Lishmanov, IuB; Prum, IA; Slepushkin, VD | 1 |
Amosova, EN; Iremenko, KV; Lishmanov, IuB; Slepushkin, VD | 1 |
Mazneva, LM; Nasonov, EL; Titov, MI; Vasil'eva, EV; Vinogradov, VA | 1 |
Karpov, IuA; Samarenko, MB | 1 |
Bocheva, A; Dimitrov, E; Ivancheva, C; Pencheva, N; Radomirov, R | 2 |
Kozloba, MV; Slepko, NG | 1 |
Kalentchuk, V; Kozlova, M | 1 |
Kentroti, S; Kozlova, M; Vernadakis, A | 1 |
Pacáková, V; Stulík, K; Suchánková, J | 1 |
Iakimovskiĭ, AF | 1 |
Kalinskaia, LN; Kononenko, VIa | 1 |
Makarenko, TG; Sitdikov, FG | 1 |
Gurevich, KG; Meshavkin, VK; Toropov, AV; Zozulia, AA | 1 |
Bebiakova, NA; Mikhaĭlova, SD; Semushkina, TM; Sokolov, AV; Storozhakov, GI | 1 |
Fedorova, NA; Karpov, RS; Lishmanov, IuB; Maslov, LN; Sokolov, AA | 1 |
Bocharov, EV; Borisov, YA; Dadayan, AK; Dorokhova, EM; Myasoedov, NF; Vaskovsky, BV; Zolotarev, YA | 1 |
Bespalova, ZhD; Lasukova, TV; Maslov, LN; Nagase, H; Oldgen, P; Rice, KK | 1 |
Barth, T; Fanali, S; Hauzerová, L; Kasicka, V; Solínová, V | 1 |
Fleishman, MU; Lebedko, OA; Sazonova, EN; Timoshin, SS; Zivotova, EU | 1 |
Abbood, A; Herrenknecht, C; Smadja, C; Taverna, M | 1 |
3 review(s) available for enkephalin, leucine and enkephalin-leu, ala(2)-arg(6)-
Article | Year |
---|---|
[Synthetic neuropeptides--a new direction in anesthesiology (possible mechanisms of action)].
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Neuroleptanalgesia; Neuropeptides; Receptors, Opioid | 1990 |
[Dalargin--the first enkephalin analog, used in gastroenterology].
Topics: Acute Disease; Animals; Dogs; Duodenum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Humans; Intestinal Mucosa; Pancreas; Pancreatitis; Peptic Ulcer; Rats; Wound Healing | 1988 |
[Opioid hexapeptide dalargin in the pathogenetic therapy of diseases of the digestive organs].
Topics: Animals; Digestive System Diseases; Digestive System Physiological Phenomena; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Rats | 1988 |
10 trial(s) available for enkephalin, leucine and enkephalin-leu, ala(2)-arg(6)-
Article | Year |
---|---|
[Dalargin in the treatment of arteriosclerosis obliterans of the lower extremities].
Topics: Adult; Arteriosclerosis Obliterans; Clinical Trials as Topic; Drug Evaluation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Leg; Middle Aged; Placebos; Sympatholytics | 1990 |
[Treatment of peptic ulcer hemorrhage with leucine enkephalin analog dalargin].
Topics: Adult; Aged; Anti-Ulcer Agents; Clinical Trials as Topic; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Middle Aged; Peptic Ulcer Hemorrhage; Stomach Ulcer; Wound Healing | 1990 |
[The effect of various types of stress-limiting therapy on the outcome of myocardial infarction].
Topics: Aged; Antioxidants; Clinical Trials as Topic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Male; Myocardial Infarction; Phosphocreatine; Piracetam; Propranolol; Sodium Oxybate; Stress, Physiological; Verapamil | 1990 |
[Receptor characteristics of the duodenal mucosa in peptic ulcer: a new approach to the individual selection of the therapy].
Topics: Adolescent; Adult; Anti-Ulcer Agents; Clinical Trials as Topic; Duodenal Ulcer; Duodenum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Intestinal Mucosa; Male; Middle Aged; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Receptors, Opioid | 1989 |
[Dalargin electrophoresis as a method of treatment in duodenal ulcer].
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Iontophoresis; Male; Middle Aged; Wound Healing | 1988 |
[Evaluation of the effectiveness of anti-ulcer preparations (dalargin, gastrocepin, solcoseryl) in the ambulatory treatment of peptic ulcer].
Topics: Actihaemyl; Adult; Aged; Ambulatory Care; Anti-Ulcer Agents; Clinical Trials as Topic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Male; Middle Aged; Parasympatholytics; Peptic Ulcer; Tissue Extracts | 1988 |
[Functioning of the pituitary-adrenal system during the vestibulo-vegetative syndrome and administration of dalargin and nalorphine].
Topics: Autonomic Nervous System Diseases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Labyrinth Diseases; Male; Nalorphine; Pituitary-Adrenal System; Syndrome; Vestibule, Labyrinth | 1987 |
[Clinical approval of dalargin--a new agent for treating peptic ulcer].
Topics: Adolescent; Adult; Anti-Ulcer Agents; Cimetidine; Clinical Trials as Topic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Injections, Intramuscular; Male; Middle Aged; Peptic Ulcer; Recurrence | 1986 |
[The synthetic peptide preparation dalargin in the treatment of peptic ulcer].
Topics: Adolescent; Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Middle Aged | 1987 |
[Clinical response to agonists of mu and beta opiate receptors in patients with ischemic heart disease: effects of D-Ala2-Leu5-Arg6-enkephalin on hemodynamics, oxygen balance and lipid spectrum of blood].
Topics: Adrenergic beta-Agonists; Anti-Arrhythmia Agents; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Hemodynamics; Humans; Injections, Intravenous; Lipoproteins; Male; Middle Aged; Myocardial Ischemia; Receptors, Opioid; Receptors, Opioid, mu | 2002 |
115 other study(ies) available for enkephalin, leucine and enkephalin-leu, ala(2)-arg(6)-
Article | Year |
---|---|
[The effect of synthetic enkephalins on prostaglandin synthesis and lipid peroxidation in the isolated heart during the activation of free-radical processes].
Topics: Animals; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Free Radicals; Heart; In Vitro Techniques; Lipid Peroxidation; Myocardium; Prostaglandins; Rats; Thromboxanes | 1992 |
[The contractile activity of the lymphatic microvessels and the role of opioid peptides in its regulation].
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Lymphatic System; Male; Mesentery; Muscle Contraction; Naloxone; Rats | 1992 |
[Role of enkephalins in the mechanism of anti-arrhythmia effects of adaptation in acute myocardial ischemia].
Topics: Acute Disease; Adaptation, Physiological; Animals; Cold Temperature; Enkephalin, Leucine-2-Alanine; Enkephalins; Exercise; Heart; Male; Myocardial Ischemia; Myocardium; Nucleotides, Cyclic; Rats; Rats, Wistar; Sympatholytics; Ventricular Fibrillation | 1992 |
[The effect of opioid peptides on the size of the cellular aggregates in a cell culture of rat embryonic spinal cord].
Topics: Animals; Cell Aggregation; Cell Survival; Cells, Cultured; Embryo, Mammalian; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Rats; Rats, Wistar; Spinal Cord; Time Factors | 1992 |
[Effects of agonists of opiate receptors on myocardial energetics of rats with hemorrhagic shock].
Topics: Adenine Nucleotides; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Myocardium; Rats; Rats, Inbred Strains; Receptors, Opioid; Shock, Hemorrhagic | 1991 |
[Participation of central and peripheral mu- and delta opiate receptors in anti-arrhythmia action of enkephalins].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Myocardial Infarction; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Ventricular Fibrillation | 1991 |
[The opiate-binding proteins of the synaptic membranes in the rat brain].
Topics: Animals; Brain; Carrier Proteins; Cell Adhesion Molecules; Chemical Phenomena; Chemistry, Physical; Chromatography, Affinity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GPI-Linked Proteins; Indicators and Reagents; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Rats; Rats, Inbred Strains; Receptors, Opioid; Sepharose; Synaptic Membranes | 1991 |
Comparative studies on the effects of some enkephalin agonists on the ERG of frog and turtle.
Topics: Animals; Electroretinography; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Morphine; Naloxone; Rana ridibunda; Receptors, Opioid; Retina; Sympatholytics; Turtles | 1990 |
[Participation of agonists and antagonist of opiate receptors in the regulation of contractile activity of lymphatic microvessels of the rat mesentery].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lymphatic System; Male; Mesentery; Naloxone; Rats; Receptors, Opioid; Sympatholytics | 1990 |
[Study of xanthine oxidase activity in the brain tissue after administration of dalargin during myoplegia].
Topics: Androstane-3,17-diol; Androstanols; Anesthesia, Inhalation; Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Neuromuscular Blocking Agents; Neuromuscular Nondepolarizing Agents; Pipecuronium; Piperazines; Rats; Respiration, Artificial; Sympatholytics; Xanthine Oxidase | 1990 |
[The antinociceptive properties of dalargin as an agent of anesthesiologic protection].
Topics: Analgesics; Androstane-3,17-diol; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hemodynamics; Male; Muscle Relaxants, Central; Muscle Relaxation; Naloxone; Pipecuronium; Piperazines; Rats; Rats, Inbred Strains | 1990 |
[Enkephalin blockade of the stimulating effect of parathormone on adrenal cortex function].
Topics: Adrenal Cortex; Aldosterone; Animals; Calcium; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrocortisone; Male; Parathyroid Hormone; Rats | 1990 |
[Effects of dalargin on proliferative processes and vertical migration of cells of the corneal epithelium during stress].
Topics: Animals; Cell Division; Cell Movement; Cornea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epithelium; Male; Rats; Stress, Physiological; Sympatholytics | 1990 |
[Effect of the leucine enkephalin analog dalargin on the components of the sympathetico-adrenal system in experimental myocardial infarction].
Topics: Adrenal Medulla; Adrenergic Fibers; Animals; Catecholamines; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Male; Myocardial Infarction; Rabbits | 1990 |
[The possibility of predicting the antinociceptive effect of dalargin in the preoperative period].
Topics: Adult; Analgesics; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials, Somatosensory; Humans; Middle Aged; Pain; Preanesthetic Medication; Sensory Thresholds | 1990 |
[A new method of general anesthesia in pulmonary surgery using dalargin instead of narcotic analgesics].
Topics: Adult; Analgesics; Anesthesia, General; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Lung; Male; Middle Aged; Neuroleptanalgesia | 1990 |
[The inhibitory effect of the synthetic leu-enkephalin analog dalargin on carcinogenesis].
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Methylnitrosourea; Neoplasms, Experimental; Rats; Sympatholytics; Time Factors | 1990 |
[Gastrin, gamma-endorphin and somatostatin cells of the stomach and duodenum in patients with duodenal ulcer treated with dalargin].
Topics: Adult; Chromaffin System; Duodenal Ulcer; Duodenum; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enterochromaffin Cells; gamma-Endorphin; Gastrins; Gastrointestinal Hormones; Humans; Male; Pyloric Antrum; Somatostatin | 1987 |
[Blood flow in skin wound tissue and systemic hemodynamics as affected by a collagen-dalargin complex].
Topics: Animals; Collagen; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Granulation Tissue; Hemodynamics; Male; Neovascularization, Pathologic; Rats; Wound Healing | 1987 |
[Effect of the synthetic Leu enkephalin dalargin on the protein and nucleic acid content of the muscles in the rainbow trout].
Topics: Animals; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Muscle Proteins; Ovum; RNA; Salmonidae; Time Factors; Trout | 1989 |
[The action of an enzymatically stable Leu-enkephalin analog on the prostanoid content in the myocardium under stress- and adrenaline-induced damage].
Topics: Animals; Avoidance Learning; Conditioning, Classical; Conflict, Psychological; Drug Evaluation, Preclinical; Drug Stability; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Epoprostenol; Heart; Myocardium; Prostaglandins; Rats; Stress, Psychological; Thromboxanes | 1989 |
[Effects of opioid receptor ligands on DNA synthesis and histamine contents in the gastric mucosa and blood of white rats].
Topics: Animals; Anti-Ulcer Agents; Autoradiography; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Histamine; Ligands; Male; Naloxone; Rats; Receptors, Opioid; Spectrometry, Fluorescence | 1989 |
[A comparative study of the effectiveness of regulatory peptides in acute experimental pancreatitis].
Topics: Acute Disease; Animals; Calcitonin; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Mononuclear Phagocyte System; Pancreatitis; Phagocytosis; Radionuclide Imaging; Somatostatin; Sympatholytics | 1989 |
[The effect of regulator peptides on pancreatic endocrine function in experimental acute pancreatitis].
Topics: Acute Disease; Animals; Calcitonin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Pancreas; Pancreatitis; Peptides; Rats; Somatostatin; Time Factors | 1989 |
[The effect of the peptide dalargin on wound healing].
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Rats, Inbred Strains; Wound Healing | 1989 |
[Use of a synthetic opioid for the reversal of stress-induced damage of the myocardium and gastric mucosa in severe thermal trauma].
Topics: Animals; Burns; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Heart; Heart Failure; In Vitro Techniques; Male; Models, Cardiovascular; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological | 1989 |
[Effects of several regulatory peptides on the functional activity of the pancreas in acute experimental pancreatitis].
Topics: Acute Disease; alpha-Amylases; Amidinotransferases; Animals; Calcitonin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lipase; Lipid Peroxidation; Male; Pancreas; Pancreatitis; Rats; Somatostatin; Sympatholytics; Trypsin; Xanthine Oxidase | 1989 |
[Use of synthetic analogs of enkephalins as antiatherogenic means].
Topics: Adult; Animals; Arteriosclerosis Obliterans; Cholesterol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Lactates; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Parathyroid Hormone; Rats; Rats, Inbred Strains; Sympatholytics | 1989 |
[Effects of dalargin, a synthetic analog of endogenous opioids, on functional indices of isolated rat heart in experimental toxemia in vitro].
Topics: Animals; Bacterial Toxins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Hemodynamics; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Staphylococcus aureus; Sympatholytics; Toxemia | 1989 |
[Dalargin in the prevention of acute postoperative pancreatitis].
Topics: Acute Disease; Adult; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Intraoperative Care; Male; Middle Aged; Pancreatic Diseases; Pancreatitis; Postoperative Complications; Rats; Sympatholytics | 1989 |
[Results of the use of dalargin electrophoresis to correct mental disorders in patients with hypertension grades I and II].
Topics: Adult; Anxiety Disorders; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Hypertension; Iontophoresis; Male; Memory Disorders; Middle Aged; Neurocognitive Disorders; Psychomotor Performance | 1989 |
[Anti-ischemic effect of the new Soviet drug dalargin].
Topics: Adult; Coronary Disease; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Extremities; Humans; Ischemia; Male; Microcirculation; Middle Aged; Sympatholytics | 1989 |
[Regulatory effects of opioid peptides on bone marrow hematopoiesis in stress].
Topics: Animals; Bone Marrow; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hematopoiesis; Hematopoietic Stem Cells; Immobilization; Male; Mice; Stress, Physiological; Sympatholytics | 1989 |
[Role of the peripheral catecholaminergic systems in the antistress action of neuropeptides].
Topics: Adrenal Medulla; Adrenergic Fibers; Animals; Catecholamines; Drug Evaluation, Preclinical; Dura Mater; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Neuropeptides; Rats; Receptors, Adrenergic; Receptors, Catecholamine; Restraint, Physical; Stress, Psychological; Time Factors | 1988 |
[Participation of the opioid-ergic system in the regulation of afferent reactions of the damaged myocardium].
Topics: Animals; Bradykinin; Butorphanol; Cats; Electrocardiography; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Heart Conduction System; Myocardial Infarction; Naloxone; Neurons, Afferent; Receptors, Opioid | 1988 |
[Gastrointestinal endocrine cells during the treatment of duodenal ulcer patients with the new peptide preparation dalargin].
Topics: Anti-Ulcer Agents; APUD Cells; Biopsy; Digestive System; Drug Evaluation; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans | 1986 |
[The effect of the opioid peptide dalargin on the regeneration of the rat sciatic nerve].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Nerve Regeneration; Rats; Sciatic Nerve | 1989 |
[Comparative effect of opioid receptor ligands on cell division in the epithelium of the tongue in white rats].
Topics: Animals; beta-Endorphin; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Rats; Tongue | 1987 |
[Role of opioid peptides in the neurotrophic control of the acetylcholine-sensitive membrane of rat skeletal muscle fibers].
Topics: Acetylcholine; Animals; beta-Endorphin; Diaphragm; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Muscle Denervation; Muscles; Rats; Synaptic Membranes | 1987 |
[Mechanism of the antistressor effect of D-Ala(2)-Leu(5)-Arg(6)-enkephalin].
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Crush Syndrome; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrocortisone; Male; Rats; Stress, Physiological; Thymus Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1985 |
[Dalargin--a peptide preparation with cytoprotective action].
Topics: Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hemorrhage; Humans; Lymphocytes; Mice; Necrosis; Pancreas; Rats; Receptors, Opioid; Stomach Ulcer | 1985 |
[Effect of enkephalins on the peripheral effects of adrenalin].
Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Glycogen; Heart Rate; Liver Glycogen; Male; Myocardium; Parathyroid Hormone; Rats | 1985 |
[Effect of dalargin on the content of endorphins, leucine-enkephalin ACTH and corticosterone of the blood of stressed rats].
Topics: Acute Disease; Adrenocorticotropic Hormone; Animals; Ascitic Fluid; Corticosterone; Drug Evaluation, Preclinical; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Peritonitis; Rats; Rats, Inbred Strains; Stress, Physiological; Time Factors; Toxins, Biological | 1985 |
[Anti-ulcer action and peripheral opioid activity of the products of dalargin degradation].
Topics: Animals; Anti-Ulcer Agents; Biotransformation; Drug Evaluation, Preclinical; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Hydrolysis; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1986 |
[The use of 1H-NMR-spectroscopy for the study of peptide degradation by angiotensin-converting enzyme].
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Hydrolysis; In Vitro Techniques; Kidney; Kinetics; Magnetic Resonance Spectroscopy; Peptides; Peptidyl-Dipeptidase A | 1987 |
[The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats].
Topics: Animals; Anti-Ulcer Agents; Brain; Cysteamine; Disease Models, Animal; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Subcutaneous; Male; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
[Opioid activity of peptides and wound healing of the skin].
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Skin; Wound Healing | 1987 |
[Effect of dalargin on morphologic and functional indices in experimental myocardial infarct].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Myocardial Infarction; Nitroglycerin; Propranolol; Rats | 1986 |
Monoclonal antibodies to dalargin--a synthetic analog of enkephalins.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptide Fragments | 1988 |
[Effects of opioid peptide dalargin on reparative processes in wound healing].
Topics: Administration, Topical; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fibroblasts; Granulation Tissue; Injections, Intraperitoneal; Macrophages; Male; Mitotic Index; Rats; Skin; Wound Healing | 1988 |
[The effect of methionine enkephalin, leucine enkephalin and the hexapeptide, dalargin on the morphology of cultured neurons].
Topics: Animals; Brain; Cell Division; Cells, Cultured; Chick Embryo; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Microscopy, Electron, Scanning; Neurons; Rats; Retina | 1988 |
[Experimental study of the hepatoprotective effect of transcranial transcutaneous electrostimulation and the synthetic analog of leu-enkephalin dalargin].
Topics: Animals; Brain; Electric Stimulation Therapy; Electronarcosis; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Histidine Ammonia-Lyase; Liver; Liver Diseases; Male; Rats; Transcutaneous Electric Nerve Stimulation; Urokinase-Type Plasminogen Activator | 1988 |
[Effect of opioid peptides on the lymphatic drainage of the pancreas in the rat and dog].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Evans Blue; Female; Lymph; Male; Naloxone; Pancreas; Phenazocine; Rats; Rats, Inbred Strains | 1988 |
[Participation of leu-enkephalin in regulating carbohydrate metabolism].
Topics: Animals; Blood Glucose; C-Peptide; Carbohydrate Metabolism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Insulin; Liver Glycogen; Male; Naloxone; Parathyroid Hormone; Rats | 1987 |
[Effect of dalargin on blood and lymph microcirculation].
Topics: Animals; Blood Cells; Cell Movement; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lymph; Lymphatic System; Male; Mesentery; Microcirculation; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Time Factors | 1988 |
[Ultrastructure of cardiomyocytes in the peri-infarct zone during the treatment of experimental myocardial infarct in rats using the hexapeptide dalargin].
Topics: Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Microscopy, Electron; Mitochondria, Heart; Myocardial Infarction; Myocardium; Rats | 1988 |
[Effect of the synthetic endogenous opioid analog dalargin on the natural cytotoxicity of human lymphocytes].
Topics: Cytotoxicity, Immunologic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; In Vitro Techniques; Lymphocytes | 1988 |
[Morphofunctional changes in the pancreas in response to dalargin under normal conditions and in experimental pancreatitis].
Topics: Acute Disease; Animals; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Pancreas; Pancreatic Juice; Pancreatitis; Rats | 1988 |
[Effect of synthetic analogs of L-enkephalin on viable areas of the pancreas in experimental pancreatitis].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Pancreas; Pancreatitis; Rats | 1988 |
[Modulating effect of opioid peptides on hemopoiesis in stress].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hematopoiesis; Immobilization; Male; Mice; Stress, Psychological | 1988 |
[Bioavailability of dalargin and its metabolism during intranasal administration to rats].
Topics: Administration, Intranasal; Animals; Anti-Ulcer Agents; Biological Availability; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Rats, Inbred Strains | 1988 |
[Effect of a stable analog of leu-enkephalin, dalargin, on the cell division of the corneal epithelium in white rats].
Topics: Animals; Cell Division; Cornea; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mitotic Index; Rats | 1988 |
[Pharmacological correction of experimental alcoholic embryopathy].
Topics: Animals; Avoidance Learning; Conditioning, Classical; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Fetal Alcohol Spectrum Disorders; Motor Cortex; Photic Stimulation; Pregnancy; Rats; Succinate Dehydrogenase; Visual Cortex | 1988 |
[Effect of a synthetic analog of leu enkephalin on the status of higher mental functions in alcoholism].
Topics: Adult; Alcoholism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Higher Nervous Activity; Humans; Memory; Middle Aged; Neuropsychological Tests; Verbal Learning | 1987 |
[Effect of the synthetic enkephalin dalargin on metabolic indices in myocardial infarct patients].
Topics: Adult; Aged; Blood Glucose; Calcium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Lactates; Magnesium; Male; Metabolism; Middle Aged; Myocardial Infarction; Triglycerides; Urea | 1987 |
[Immunomodulating action of neuropeptides in in vitro systems].
Topics: Adjuvants, Immunologic; Cell Migration Inhibition; Cells, Cultured; Coronary Disease; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Lymphocytes; Neuropeptides; Rosette Formation | 1987 |
[Effect of enkephalins on the adenine nucleotide concentrations of the liver and heart in experimental myocardial infarct].
Topics: Adenine Nucleotides; Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Liver; Male; Myocardial Infarction; Myocardium; Rats | 1987 |
[Effect of opioid receptor ligands on cell division processes in the corneal epithelium of the white rat].
Topics: Animals; Cell Division; Cornea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epithelium; Male; Naloxone; Rats | 1987 |
[Effect of tageflar, a synthetic analog of L-enkephalin, on the morphogenesis of experimental pancreatitis].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Pancreatitis; Rats | 1987 |
[Levels of hypophyseal-adrenal system hormones in the blood of acute myocardial infarct patients under treatment with the Soviet hexapeptide dalargin].
Topics: Adrenal Cortex Hormones; Adult; Aged; Drug Evaluation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Middle Aged; Myocardial Infarction; Pituitary Hormones | 1987 |
[Features of the action of opioid peptides and naloxone on the tissues of the central and peripheral nervous system during cultivation].
Topics: Animals; Culture Techniques; Drug Interactions; Embryo, Mammalian; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Naloxone; Organ Specificity; Rats; Rats, Inbred Strains; Spinal Cord | 1986 |
[Effect of enkephalins on the energy potential of the rat liver and cerebral cortex during an early period of traumatic shock].
Topics: Adenine Nucleotides; Animals; Cerebral Cortex; Energy Metabolism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Liver; Male; Rats; Shock, Traumatic; Time Factors | 1986 |
[Radioimmunologic and radioreceptor studies of the pharmacokinetics of the enkephalin analog dalargin in man].
Topics: Adult; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Male; Middle Aged; Radioimmunoassay; Radioligand Assay | 1986 |
[In vitro modulation using a synthetic antioxidant of the stimulus-induced formation of cyclic AMP].
Topics: Adenylyl Cyclases; Animals; Antioxidants; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Induction; Glucagon; In Vitro Techniques; Isoproterenol; Phenylpropionates; Rats | 1986 |
[Effect of dalargin on systolic pressure in chronic experimental disorders of cardiovascular regulation].
Topics: Animals; Blood Pressure; Chronic Disease; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypertension, Renovascular; Male; Myocardial Contraction; Rats; Renal Artery Obstruction; Stress, Psychological; Systole | 1986 |
[Effect of dalargin on the glucocorticoid activity of the adrenals in stress].
Topics: Adrenal Glands; Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glucocorticoids; Rats; Stress, Physiological | 1986 |
[Effect of dalargin on the course of stress and shock in an experiment].
Topics: Animals; Crush Syndrome; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Shock, Traumatic; Stress, Psychological | 1986 |
[Dalargin--the most active synthetic analog of endogenous opioids for treating peptic ulcer (the results of a 5-year search)].
Topics: Animals; Anti-Ulcer Agents; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Peptic Ulcer | 1986 |
[Evaluation of the effectiveness of dalargin in treating exacerbated peptic ulcer under outpatient conditions at medical health units].
Topics: Adult; Ambulatory Care; Anti-Ulcer Agents; Drug Evaluation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Peptic Ulcer; Time Factors | 1986 |
[Effect of dalargin on the level of gastric secretion].
Topics: Animals; Anti-Ulcer Agents; Dogs; Drug Evaluation; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Acid; Humans; Peptic Ulcer | 1986 |
[Effect of the intravenous infusion of dalargin on biochemical and hormonal indices in the blood of patients with duodenal peptic ulcer].
Topics: Adult; Anti-Ulcer Agents; Drug Evaluation; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hormones; Humans; Infusions, Intravenous; Male; Middle Aged | 1986 |
[Assessment of the endocrine status of peptic ulcer patients being treated with dalargin].
Topics: Anti-Ulcer Agents; Drug Evaluation; Duodenal Ulcer; Endocrine Glands; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Time Factors | 1986 |
[Effect of dalargin on pancreatic secretion].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Pancreas; Pancreatic Juice; Rats; Time Factors | 1986 |
[Effect of the peripheral administration of dalargin on ornithine decarboxylase activity in the duodenal mucosa of rats with experimental duodenal ulcers].
Topics: Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Duodenal Ulcer; Duodenum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraperitoneal; Intestinal Mucosa; Male; Ornithine Decarboxylase; Rats; Rats, Inbred Strains | 1986 |
[Dalargin--a regulator of reparative tissue regeneration].
Topics: Animals; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Rats, Inbred Strains; Regeneration; Swine; Swine, Miniature; Time Factors; Wound Healing | 1986 |
[Comparative study by a radioreceptor method of the pharmacokinetics of opiate ligands: morphine and dalargin].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Ligands; Morphine; Radioligand Assay; Time Factors | 1986 |
[Degradation of dalargin and its analogs in the brush border membranes of rat enterocytes studied by 1H-NMR spectroscopy].
Topics: Animals; Biotransformation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrolysis; Intestines; Magnetic Resonance Spectroscopy; Microvilli; Rats | 1986 |
[Effect of an opioid peptide on the healing of experimental myocardial infarct].
Topics: Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Microscopy, Electron; Myocardial Infarction; Myocardium; Necrosis; Rabbits; Time Factors; Wound Healing | 1986 |
[Effect of the hexapeptide dalargin on ornithine decarboxylase activity in the duodenal mucosa of rats in experimental duodenal ulcer].
Topics: Animals; Anti-Ulcer Agents; Cysteamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Duodenal Ulcer; Duodenum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Intestinal Mucosa; Male; Ornithine Decarboxylase; Rats; Rats, Inbred Strains | 1987 |
[Study of peptide degradation in the serum by 1H-NMR].
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Oligopeptides | 1986 |
[Effect of enkephalins on the function of the calcium-regulating endocrine glands in shock].
Topics: Animals; Calcitonin; Calcium; Drug Evaluation, Preclinical; Endocrine Glands; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Parathyroid Hormone; Rats; Shock, Hemorrhagic; Shock, Traumatic; Time Factors | 1986 |
[Enkephalins and the function of the sympathetic-adrenal system in acute myocardial ischemia].
Topics: Adrenal Glands; Animals; Catecholamines; Coronary Disease; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Sympathetic Nervous System; Time Factors | 1985 |
[Effect of enkephalins on metabolic indices in experimental myocardial infarct in rats].
Topics: Animals; Blood Glucose; Calcium; Diuresis; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lactates; Liver Glycogen; Magnesium; Male; Myocardial Infarction; Rats | 1985 |
[Biochemical aspects of enkephalin participation in the regulation of adrenergic effects on myocardium].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Creatine Kinase; Cyclic AMP; Cyclic GMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Isoenzymes; Isoproterenol; Magnesium; Male; Myocardium; Rabbits; Rats | 1984 |
[Mechanism of the hypotensive effect of parathyroid hormone].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Cyclic AMP; Depression, Chemical; Droperidol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Muscle, Smooth, Vascular; Parathyroid Hormone; Rats; Verapamil | 1984 |
[Effect of enkephalins on vasopressin and aldosterone levels in acute experimental myocardial ischemia].
Topics: Aldosterone; Animals; Coronary Disease; Diuresis; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Rats; Vasopressins | 1984 |
[Anti-stress effect of D-Ala2-Leu5-Arg6-enkephalin].
Topics: Adrenal Glands; Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Organ Size; Plant Extracts; Rats; Spleen; Stress, Physiological; Thymus Gland | 1984 |
[Modulation of the proliferative response of lymphocytes with a new enkephalin analog--dalargin].
Topics: Arthritis, Rheumatoid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Lupus Erythematosus, Systemic; Lymphocyte Activation; Lymphopenia; Oligopeptides | 1984 |
[1st experiment in the clinical use of the Soviet synthetic peptide, dalargin in patients with ischemic heart disease].
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Dose-Response Relationship, Drug; Drug Evaluation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Hemodynamics; Humans; Middle Aged; Myocardial Contraction; Stroke Volume | 1983 |
Dalargin and [Cys-(O2NH2)]2 analogues of enkephalins and their selectivity for mu opioid receptors.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Naloxone; Receptors, Opioid, mu; Sympatholytics; Tetrodotoxin | 1995 |
[The effect of opioid peptides on a decreased proliferation and on an increased maturation rate of glioma C-6 cells manifested by enhanced marker enzyme activity].
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Glutamate-Ammonia Ligase; Phenotype; Rats; Time Factors; Tumor Cells, Cultured | 1994 |
Stimulatory effect of opioid peptides and naloxone on rat spinal cord cells in primary dissociated culture.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Molecular Sequence Data; Naloxone; Nerve Growth Factors; Rats; Rats, Wistar; Spinal Cord; Stimulation, Chemical | 1994 |
Maintenance of glial plasticity with aging in C-6 glial cells and normal astrocytes in culture: responsiveness to opioid peptides.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amino Acid Sequence; Animals; Astrocytes; Cellular Senescence; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Glutamate-Ammonia Ligase; Mice; Mice, Inbred C3H; Molecular Sequence Data; Nerve Tissue Proteins; Neuroglia; Neuronal Plasticity; Oligodendroglia; Tumor Cells, Cultured | 1993 |
Separation of biologically active peptides by capillary electrophoresis and high-performance liquid chromatography.
Topics: Amino Acid Sequence; Buffers; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Oligopeptides | 1996 |
[Cys(O2NH2)2]enkephalin analogues and dalargin: selectivity for delta-opioid receptors.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Norepinephrine; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1996 |
[The realization of food-acquisition behavior in rats against a background of multiple injections of enkephalin-like peptides into the neostriatum].
Topics: Animals; Conditioning, Classical; Enkephalin, Leucine-2-Alanine; Enkephalins; Feeding Behavior; Male; Microinjections; Neostriatum; Rats; Rats, Wistar; Time Factors | 1996 |
[The interaction of the renin-angiotensin and enkephalinergic systems of the brain and hypophysis in normal rats and in experimental pathology of the hypothalamo-hypophyseal-adrenal complex].
Topics: Adrenalectomy; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Brain Chemistry; Captopril; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamo-Hypophyseal System; Male; Pituitary Gland; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Opioid; Renin-Angiotensin System; Time Factors | 1996 |
[Effects leu-enkephalin and dalargin on the cardiac activity in rats during stimulation of postganglionic sympathetic fibers with low frequency impulses].
Topics: Animals; Autonomic Fibers, Postganglionic; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Myocardial Contraction; Rats; Stroke Volume | 1999 |
[Anxiolytic effect of dalargin on rat behavior in the Vogel conflict test and the raised cross-like labyrinth].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Conflict, Psychological; Drinking Behavior; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Motor Activity; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Water Deprivation | 1999 |
[Effects of opioid peptides on ischemic myocardial arrhythmias during laser irradiation and disturbed heart sympathetic innervation].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Heart; Lasers; Male; Myocardial Ischemia; Myocardium; Opioid Peptides; Receptors, Opioid; Sympathectomy | 1999 |
New development in the tritium labelling of peptides and proteins using solid catalytic isotopic exchange with spillover-tritium.
Topics: Amino Acid Sequence; Animals; Brain; Catalysis; Conotoxins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Galactosidases; Hydrogen; Isotope Labeling; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Peptaibols; Peptides; Proteins; Radioligand Assay; Rats; Receptors, Opioid; Temperature; Tritium | 2003 |
Delta-opioid receptor antagonists exhibit properties of partial delta-receptor agonists in isolated perfused heart.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Naltrexone; Oligopeptides; Perfusion; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta | 2004 |
Analysis and separation of enkephalin and dalargin analogues and fragments by capillary zone electrophoresis.
Topics: Electrolytes; Electrophoresis, Capillary; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; Microchemistry; Molecular Weight; Peptide Fragments; Sensitivity and Specificity | 2005 |
Effect of dalargin on DNA synthesis in the gastric mucosa of albino rats.
Topics: Animals; Cell Proliferation; DNA; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Inhibitors; Gastric Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats | 2007 |
Hydrophilic interaction liquid chromatography for dalargin separation from its structural analogues and side products.
Topics: Ammonium Compounds; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Ions; Osmolar Concentration; Peptides; Silicon Dioxide; Spectrometry, Mass, Electrospray Ionization | 2017 |