enkephalin, leucine has been researched along with enkephalin, methionine in 1497 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 959 (64.06) | 18.7374 |
| 1990's | 402 (26.85) | 18.2507 |
| 2000's | 96 (6.41) | 29.6817 |
| 2010's | 35 (2.34) | 24.3611 |
| 2020's | 5 (0.33) | 2.80 |
| Authors | Studies |
|---|---|
| Higashijima, T; Kobayashi, J; Miyazawa, T; Nagai, U | 1 |
| Nomoto, T; Tonoue, T | 1 |
| Coy, DH; Kastin, AJ; Lahoste, GJ; Olson, GA; Olson, RD | 1 |
| del Río, J; Garzón, J; Moratalla, R | 2 |
| Hua, JS; Ji, RY; Yin, DX; Zong, RS | 1 |
| Tang, F; Vacca-Galloway, LL; Yung, KK | 2 |
| Di Giulio, AM; Donadoni, ML; Finco, C; Germani, E; Gorio, A; Malosio, ML; Mantegazza, P; Tenconi, B | 1 |
| Afanas'ev, SA; Kravchenko, AI; Lishmanov, IuB; Rebrova, TIu | 1 |
| Fedulova, SA; Rózsa, KS; Valasek, Z | 1 |
| Jiang, ZG; North, RA | 1 |
| Lotz, M; Villiger, PM | 1 |
| Gintzler, AR; Xu, H | 3 |
| Akami, T; Arakawa, K; Matsumoto, S; Mitsuo, M; Nagase, H; Nakai, I; Nakajima, H; Oka, T; Okamoto, M | 1 |
| Haaseth, RC; Horan, P; Hruby, VJ; Matsunaga, TO; Porreca, F; Tallarida, RJ | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Carpenter, DO; Kemenes, G; Rózsa, KS; Stefano, G | 1 |
| Haberstok, H; Hrsak, I; Marotti, T; Sverko, V | 1 |
| Edwards, AV; Jones, CT; Tindell, D | 1 |
| Browne, CA; Coulter, CL; McMillen, IC; Young, IR | 1 |
| Finberg, RW; Heagy, W; Shipp, MA | 1 |
| Arany, I; Lee, NM; Loh, HH; Zhang, X | 1 |
| Ishikawa, K; Martinez, JL; Schulteis, G; Shibanoki, S; Weinberger, SB | 1 |
| Johnson, SW; North, RA | 1 |
| Armstead, WM; Crofton, JT; Leffler, CW; Mirro, R; Share, L; Zuckerman, SL | 1 |
| Goriacheva, TV; Karganov, MIu; Khlebnikova, NN; Kryzhanovskiĭ, GN; Lutsenko, VK | 1 |
| Armstead, WM; Busija, DW; Leffler, CW; Mirro, R; Zuckerman, S | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T; Wada, M | 1 |
| Cechetto, DF; Oppenheimer, SM; Saleh, T | 1 |
| Marini, AM; Schwartz, JP; Shinoda, H | 1 |
| Eiden, LE; Hsu, CM; Iacangelo, AL; MacArthur, L | 1 |
| Aloyz, R; Finkielman, S; Kleid, MC; Nahmod, VE; Rodríguez Vida, MI; Vindrola, O | 1 |
| Geffard, M; Gouy, D; Marlier, L; Passagia, JG; Pellas, F; Poulat, P; Privat, A; Rajaofetra, N; Sandillon, F; Verschuere, B | 1 |
| Halperin, N; Nevo, Z; Robinson, D; Segal, M | 1 |
| Beckstead, RM; Somers, DL | 1 |
| Monger, LS; Olliff, CJ | 1 |
| Du, YH; Fielding, R; Tang, F; Vacca-Galloway, LL; Yung, KK | 1 |
| De Ceballos, ML; Jenner, P; Marsden, CD; Rose, S; Taylor, MD | 1 |
| Chiverton, JA; Holtsclaw, LI; Williams, CA | 1 |
| Kovács, GL; Kriván, M; Sarnyai, Z; Szabó, G; Telegdy, G | 1 |
| Cheng Chew, SB; Leung, PY | 1 |
| Arai, Y; Ghoda, K; Kajita, T; Liu, XF; Matsumiya, T; Ohgiya, N; Oka, T; Taniguchi, T | 1 |
| Boulom, K; Fannin, R; Hong, JS; Hudson, P; McMillian, MK; Poisner, AM; Suh, HH | 1 |
| Beauvillain, JC; Mazzuca, M; Mitchell, V | 3 |
| Bakich, V; Law, S; McIntosh, CH | 1 |
| Dores, RM; McDonald, LK | 1 |
| Bhattacharya, SK; Saraswati, M; Sen, AP | 1 |
| Hong, JS; Hudson, PM; Mar, EC; McMillian, MK; Suh, HH | 1 |
| Chiou, GC; Li, BH; Shen, ZF; Zheng, YQ | 1 |
| Nakamura, H; Suzuki, N; Yoshino, S | 1 |
| Bennett, DJ; Cripps, MM | 1 |
| Baba, M; Iishi, H; Okuda, S; Taniguchi, H; Tatsuta, M | 1 |
| Mpitsos, GJ; Soinila, J; Soinila, S | 1 |
| Carnevali, O; Facchinetti, F; Mosconi, G; Pestarino, M; Polzonetti-Magni, A; Vallarino, M | 1 |
| Cornish, T; Cotter, RJ | 1 |
| De Marco, C; Mosca, L; Rosei, MA | 1 |
| Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Hook, VY; Krieger, TJ; Mende-Mueller, L | 1 |
| Coenen, AM; Lasoń, W; Przewłocka, B; Przewłocki, R; Van Luijtelaar, EL | 1 |
| Bergasa, NV; Jones, EA; Rothman, RB; Swain, MG; Vergalla, J; Xu, H | 1 |
| Jones, CT | 1 |
| Agoston, DV; Brenneman, DE; Eiden, LE | 1 |
| deCosta, B; Jiang, Q; Porreca, F; Rice, KC | 1 |
| Blarzino, C; Coccia, R; De Marco, C; Foppoli, C; Rosei, MA | 1 |
| Branch, AD; Franklin, SO; Inturrisi, CE; Robertson, HD; Yoburn, BC; Zhu, YS | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Chantrel, D; Collin, E; Hamon, M; Mauborgne, A; Pohl, M | 1 |
| Gibo, DM; McLaughlin, PJ; Zagon, IS | 1 |
| Barthel, F; Becquet, D; Boudouresque, F; Giraud, P; Grino, M; Kowalski, C; Loeffler, JP; Renard, M | 1 |
| Frank, C; Proietti, ML; Sagratella, S; Scotti De Carolis, A; Trampus, M | 2 |
| al-Obeidi, F; Pettitt, BM; Smith, PE | 1 |
| Hauser, KF; Stiene-Martin, A | 1 |
| Grider, JR; Makhlouf, GM | 1 |
| Adams, ML; Brase, DA; Dewey, WL; Morris, DL | 1 |
| Bunn, SJ; Dunkley, PR | 1 |
| Gros, C; Llorens-Cortes, C; Schwartz, JC; Zini, S | 1 |
| Armstead, WM; Busija, DW; Desiderio, DM; Leffler, CW; Mirro, R | 1 |
| de Ceballos, ML; Jenner, P; Marsden, CD; Taylor, MD | 1 |
| Bauer, AJ; Szurszewski, JH | 1 |
| Bayon, A; Leon-Olea, M; Piña, AL; Sanchez-Alvarez, M | 1 |
| Casellas, AM; Guardiola, H; Renaud, FL | 1 |
| Ishikawa, K; Martinez, JL; Shibanoki, S; Weinberger, SB | 3 |
| Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL | 1 |
| Michaelson, DM; Oron, L; Sarne, Y | 1 |
| Bunnett, NW; Gu, ZF; Maton, PN; Menozzi, D | 1 |
| Bruno, JA; Carvalho, KM; de Souza, AN | 1 |
| Asai, M; Gutiérrez, R | 1 |
| Coleman, DL; Powell, AM; Recant, L; Rökaeus, A; Timmers, K; Voyles, NR | 1 |
| Cheung, A; Tang, F; Vacca-Galloway, LL | 1 |
| Polakiewicz, RD; Rosen, H; Simantov, R | 1 |
| Kew, D; Kilpatrick, DL; Muffly, KE | 1 |
| Christofi, FL; Cook, MA; McDonald, TJ | 1 |
| Chipkin, RE; Lucas, D; Mjanger, E; Sabbe, MB; Yaksh, TL | 1 |
| Capelli, A; Larocca, LM; Lauriola, L; Maggiano, N; Piantelli, M; Ranelletti, FO; Ricci, R | 1 |
| Shimada, Y; Yamada, K; Yoshida, S | 1 |
| Chong, PN; de Ceballos, ML; Jenner, P; Marsden, CD; Rose, S; Taylor, MD | 1 |
| Man, WS; Tang, F | 1 |
| Burnstock, G; Chapple, CR; Crowe, R; Gilpin, SA; Gosling, J | 1 |
| De Ceballos, ML; Jenner, P; Taylor, MD | 1 |
| Aloyo, VJ | 1 |
| Agarwal, SK; Calaresu, FR | 1 |
| Kachidian, P; Marlier, L; Poulat, P; Privat, A | 1 |
| Lindberg, I; Shaw, E | 1 |
| Elofsson, R; Sakharov, DA | 1 |
| Dores, RM; Joss, JM; McDonald, LK | 1 |
| Batter, DK; Kessler, J; Vilijn, MH | 1 |
| Brakier-Gingras, L; Dumont, M; Lemaire, S; Ouellette, M | 2 |
| Day, R; Jhamandas, K; Ruzicka, BB | 1 |
| Anderson, KD; Reiner, A | 1 |
| Barron, BA; Caffrey, JL; Gaugl, JF; Gu, H | 1 |
| Baamonde, A; Delay-Goyet, P; Gacel, G; Morgat, JL; Roques, BP; Ruiz-Gayo, M | 1 |
| Nakamura, A; Sakai, K; Shiomi, H; Takahashi, Y | 1 |
| Corcoran, JJ; Kirshner, N; Wilson, SP | 1 |
| Wilson, SP | 3 |
| Beauvillain, JC; Mazzuca, M; Mitchell, V; Tramu, G | 1 |
| Herman, ZS; Huzarska, M; Kmieciak-Kolada, K; Kowalski, J | 1 |
| Kuis, W; Leser, HG; Lotz, M; Villiger, PM | 1 |
| Houdi, AA; Pierzchala, K; Van Loon, GR | 1 |
| Duchemin, AM; Gudehithlu, KP; Hadjiconstantinou, M; Neff, NH; Tejwani, GA | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T | 2 |
| Xie, X | 1 |
| Henke, PG; Ray, A | 1 |
| Arluison, M; Bourgoin, S; Boyer, PA; Quignon, M; Vankova, M | 1 |
| Boer, HH; Leung, MK; Lundy, J; Stefano, GB; van Minnen, J | 1 |
| Desiderio, DM; Liu, DX; Wood, GW | 1 |
| Burg-Poveda, D; Slama, A; Tramu, G | 1 |
| Erdö, F; Máté, I; Polgár, K; Székely, JI | 1 |
| Biguet, NF; Chaminade, M; Fayada, C; Guibert, B; Leviel, V; Machek, G; Mallet, J | 1 |
| Pittman, QJ; Thornhill, JA | 1 |
| Green, IC; Khawaja, XZ; Thorpe, JR; Titheradge, MA | 1 |
| Osborne, PB; Pan, ZZ; Williams, JT | 1 |
| Jia, X; Kowk, YN; McIntosh, CH | 1 |
| Armstead, WM; Busija, DW; Leffler, CW; Mirro, R | 1 |
| Hishida, F; Igarashi, O; Luo, CP; Takeshige, C | 1 |
| Carretero, OA; Mindroiu, T; Scicli, AG; Walz, D | 1 |
| Hook, VY; Krieger, TJ | 1 |
| Garduño-Juárez, R; Morales, LB; Romero, D | 1 |
| Beliaev, NA; Kelesheva, LF; Kolesanova, EF; Panchenko, LF; Rotanova, TV | 1 |
| Burks, TF; Davis, P; Davis, TP; Hoyer, GL | 1 |
| Charnay, Y; Cupo, A; Fourrier, O; Jarry, T; Leger, L; Masmejean, F | 1 |
| Jiang, G; Lin, J; Lu, G | 1 |
| Sheng, J | 1 |
| George, SR; Haas, DA; Roldan, L | 1 |
| Olley, JE; Scheer, J; Tiong, GK; von Jenner, NM | 1 |
| Nakamura, H; Yoshino, S | 1 |
| Cheng, JG; Xie, XK | 1 |
| Lin, J | 1 |
| Cone, EJ; Johnson, RE; Su, TP; Vaupel, DB | 1 |
| Gibo, D; McLaughlin, PJ; Zagon, IS | 1 |
| Bose, R; Glavin, GB; Hall, A; Pinsky, C | 1 |
| Hrsak, I; Marotti, T; Sverko, V | 2 |
| Chen, S | 1 |
| Bach, JF; Dardenne, M; Gagnerault, MC; Savino, W | 1 |
| Arluison, M; Cesselin, F; Leviel, V; Vankova, M | 1 |
| Allen, RG; Low, KG; Melner, MH | 1 |
| Aloyz, R; Ase, A; Finkielman, S; Nahmod, VE; Saravia, F; Vindrola, O | 1 |
| Heath, D; Khan, Q; Smith, P | 1 |
| Iasnetsov, VV; Pravdivtsev, VA | 1 |
| Dygai, AM; Goldberg, ED; Shakhov, VP; Zakharova, O | 1 |
| Janković, BD; Marić, D | 7 |
| Houdi, AA; Van Loon, GR | 1 |
| Cohen, E; Finberg, R; Heagy, W; Laurance, M | 1 |
| Dores, RM; Gorbman, A | 1 |
| D'Alagni, M; Gullá, P; Roda, LG; Roscetti, G | 1 |
| Browne, CA; Coulter, CL; McMillen, IC | 1 |
| Hill, JM; Kaufman, MP | 1 |
| Hiddinga, HJ; Katzenstein, GE; Lewis, RV; Middaugh, CR | 1 |
| Holm, A; Lauritzen, E; Masson, M; Rubin, I | 1 |
| Himmelfarb, GN; Schumilowa, IJ | 1 |
| Mosley, C; O'Connor, DT; Parmer, RJ | 1 |
| Ekblad, E; Ekelund, M; Graffner, H; Håkanson, R; Sundler, F | 1 |
| Fingerman, M; Hanumante, MM; Ikeda, R; Kulkarni, GK; Vacca, LL | 1 |
| Karten, HJ; Krause, JE; McKelvy, JF; White, JD | 1 |
| Cherubini, E; Morita, K; North, RA | 1 |
| Bespalova, ZhD; Il'inskiĭ, OB; Kondrikova, ES; Kozlova, MV; Titov, MI | 1 |
| Cameron, AA; Kelly, WL; Leah, JD; Snow, PJ | 1 |
| Delwaide, PJ; Reznik, M; Schoenen, J; Vanderhaeghen, JJ | 1 |
| Laurent, S; Marsh, JD; Smith, TW | 1 |
| Afsharpour, S; Kitai, ST; Penny, GR | 1 |
| Aloyo, VJ; Mousa, SA; Van Loon, GR | 1 |
| Ahlenius, S; Groenewegen, HJ; Haber, SN; Kowall, NW; Nauta, WJ | 1 |
| Bannon, MJ; Deutch, AY; Eskay, RL; Lee, JM; Maggio, JE; Roth, RH; Tam, SY; Zamir, N | 1 |
| Agid, Y; Benoliel, JT; Cesselin, F; Javoy-Agid, F; Jenner, P; Marsden, CD; Mauborgne, A; Rose, S; Taquet, H | 1 |
| ten Donkelaar, HJ; Verhofstad, AA; Wolters, JG | 1 |
| Christensson-Nylander, I; Cuello, C; Goldstein, M; Herrera-Marschitz, M; Hökfelt, T; Oertel, WH; Staines, W; Terenius, L; Ungerstedt, U | 1 |
| Agid, Y; Cesselin, F; Epelbaum, J; Javoy-Agid, F; Taquet, H | 1 |
| Finesso, M; Gorio, A; Prosdocimi, M | 1 |
| Piemontesi, F | 1 |
| Bouras, C; Magistretti, PJ; Morrison, JH | 1 |
| Lkhider, M; Marcel, R; Tramu, G | 1 |
| Adams, M; Boarder, MR; Marriott, D | 1 |
| Kaliner, MA; Logun, C; Lundgren, J; Shelhamer, JH | 1 |
| Christie, MJ; North, RA; Surprenant, A; Williams, JT | 1 |
| Agid, Y; Benoliel, JJ; Cesselin, F; Hamon, M; Javoy-Agid, F; Legrand, JC; Mauborgne, A; Taquet, H | 1 |
| Bouras, C; Constantinidis, J; Schulz, P; Tissot, R | 1 |
| Barnes, PJ; Frossard, N | 1 |
| Han, JS; Jiang, NC; Wang, JP; Yu, YX | 1 |
| Berschneider, HM; Martens, H; Powell, DW | 1 |
| Das, N; Gupta, VS; Mediratta, PK; Sen, P | 1 |
| Chen, HT; Louie, DS; Owyang, C | 1 |
| Barnett, W; Brooks, BD; Christofi, FL; Cook, MA; McDonald, TJ | 1 |
| Bunnett, NW; Hryszko, J; Kobayashi, R; Turner, AJ; Walsh, JH | 1 |
| Pruss, RM; Stauderman, KA | 1 |
| Haarmann, I; Herz, A; Höllt, V; Nikolarakis, K; Przewłocki, R | 1 |
| Bourgoin, S; Cesselin, F; Fattaccini, CM; Gozlan, H; Hamon, M; Montastruc, JL; Rascol, A; Tran, MA | 1 |
| Agid, Y; Benoliel, JJ; Javoy-Agid, F; Jenner, P; Legrand, JC; Marsden, CD; Mauborgne, A; Nomoto, M; Rose, S; Taquet, H | 1 |
| Cador, M; Kelley, AE; Le Moal, M; Stinus, L | 1 |
| Arnbjörnsson, E; Ekblad, E; Ekman, R; Håkanson, R; Sundler, F | 1 |
| Gaskell, SJ; Thorne, GC | 1 |
| Iadarola, MJ; Mouradian, MM | 1 |
| Zoloev, GK | 1 |
| Bhathena, SJ; Michaelis, OE; Recant, L; Timmers, K; Voyles, NR; Wilkins, S | 1 |
| Shafer, NP | 1 |
| Costa, E; Mocchetti, I; Ritter, A | 1 |
| Lindberg, I; Shen, FS | 2 |
| Burks, TF; Gehrig, CA; Hruby, VJ; Lemcke, PK; Shook, JE | 1 |
| DeLeon-Jones, FA; Fields, JZ; Lee, JM; Ritzmann, RF; Steece, KA | 1 |
| Masuyama, Y; Tsuda, K | 1 |
| Cadet, P; Scharrer, B; Stefano, GB | 1 |
| Kimura, T; Koyanagawa, H; Musha, T; Satoh, E; Satoh, S | 1 |
| Fuchs, BA; Loveless, SE; Munson, AE; Sikorski, EE; Srisuchart, B | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Gasparík, J | 1 |
| Laniyonu, AA; Ohia, SE | 1 |
| Cosi, C; Marini, AM; Schwartz, JP; Shinoda, H | 1 |
| Almeida, OF; Herz, A; Nikolarakis, KE; Yassouridis, A | 1 |
| Lu, ZH | 1 |
| Drasner, K; Fang, FG; Fields, HL; Haws, CM; Williamson, A | 1 |
| Gintzler, AR; Smolens, I; Xu, H | 1 |
| Maley, BE | 1 |
| Ali, SF; Hong, JS; Hudson, PM; Mason, GA; Yoshikawa, K | 1 |
| Lotstra, F; Reznik, M; Schoenen, J; Vanderhaeghen, JJ; Vierendeels, G | 1 |
| Itin, A; Keshet, E; Ornoy, A; Polakiewicz, RD; Rosen, H | 1 |
| Cheng, R; George, SR; Kim, C | 1 |
| Krehbiel, DK; Mifune, M; Riley, CM; Stobaugh, JF | 1 |
| Fainboin, L; Finkielman, S; Nahmod, VE; Padrós, MR; Vindrola, O; Zunszain, P | 1 |
| Henion, JD; Mück, WM | 1 |
| Wang, SK; Wang, YJ | 2 |
| Caverson, MM; Ciriello, J | 1 |
| Kato, Y | 4 |
| Brumbaugh, DR; Erdelyi, E; Evans, CJ; Maidment, NT; Rudolph, VD | 1 |
| Häppölä, O; Lakomy, M; Yanaihara, N | 1 |
| Lehtosalo, J; Mahrberg, T; Palkama, A; Panula, P; Uusitalo, H | 1 |
| Olley, JE; Tiong, GK | 1 |
| Asai, M; Condés-Lara, M; Omaña-Zapata, I; Talavera, E | 1 |
| Aumüller, G; Jungblut, T; Konrad, S; Malek, B; Weihe, E | 1 |
| Coghlan, JP; Scoggins, BA; Tresham, JJ; Wang, XM | 1 |
| Mize, RR | 1 |
| Foda, HD; Said, SI; Shimosegawa, T | 1 |
| Senba, E; Tohyama, M; Yanaihara, C; Yanaihara, N | 1 |
| Fan, JZ; Lin, SX; Wang, FZ | 1 |
| Eberwine, JH; Evans, CJ; Paxinos, G; Rubenstein, JL; Tecott, LH; Valentino, KL | 1 |
| Bernardi, G; Calabresi, P; Mercuri, NB; Stanzione, P; Stefani, A | 1 |
| Bhathena, SJ; Kennedy, BW; Recant, L; Smith, PM; Voyles, NR | 1 |
| Messiha, FS | 1 |
| Kuno, Y; Oka, T | 1 |
| Blancquaert, JP; Lefebvre, RA; Willems, JL | 1 |
| Kennedy, C; Krier, J | 1 |
| Moak, CM; Murphy, MG; Rao, BG | 1 |
| Donahoe, RM; Falek, A; Madden, JJ; Shafer, DA; Zwemer-Collins, J | 1 |
| Frey, EA; Jacobson, AE; Rice, KC; Tocque, B | 1 |
| Childers, SR | 1 |
| Castiglione-Morelli, MA; Pastore, A; Tancredi, T; Temussi, PA | 1 |
| Delay-Goyet, P; Gacel, G; Roques, BP; Seguin, C | 1 |
| Rand, MJ; Wong-Dusting, H | 1 |
| Henke, PG; Ray, A; Sullivan, RM | 1 |
| Aliab'eva, TN; Balashov, AM; Bumialis, VV; Panchenko, LF; Petrichenko, OB | 1 |
| McLaughlin, P; Zagon, IS | 1 |
| Casellas, AM; De Jesus, S; Guardiola, H; Renaud, FL | 1 |
| Conde, E; Lavandero, S; Puente, J; Sapag-Hagar, M | 1 |
| Magee, AI; Milligan, G; Mullaney, I; Unson, CG | 1 |
| Deguchi, T; Yokoyama, E | 1 |
| Brownstein, MJ; Eiden, LE; Eskay, RL; Faden, AI; Feuerstein, G; Palkovits, M; Weber, E; Zamir, D; Zamir, N | 1 |
| Gaudreau, P; Martel, JC; Quirion, R; St-Pierre, S; Zamir, N | 1 |
| Altschuler, RA; Fex, J; Hoffman, DW; Rubio, JA; Zamir, N | 1 |
| Mergenhagen, S; Pert, CB; Ruff, MR; Wahl, SM | 1 |
| Hoffman, DW; Zamir, N | 1 |
| Costa, M; Cuello, AC; Furness, JB | 1 |
| Zamir, N | 1 |
| Agid, Y; Cesselin, F; Giraud, P; Javoy-Agid, F; Legrand, JC; Taquet, H | 1 |
| Fujimoto, JM; Higgins, MJ; Hong, JS; Hudson, PM; Tseng, LF | 1 |
| Bitar, KN; Makhlouf, GM | 1 |
| Kalivas, PW; Miller, JS; Taylor, S | 1 |
| Livett, BG; Marley, PD; Mitchelhill, KI | 1 |
| Gray, TS; Moga, MM | 1 |
| Falke, N; Martin, R | 1 |
| Bogaert, MG; De Schaepdryver, AF; Lefebvre, RA | 1 |
| Nyberg, F; Nylander, I; Terenius, L | 1 |
| Geppert, M; Illes, P; Jackisch, R | 1 |
| Fukuda, H; Nagano, N; Oka, J; Suzuki, T | 1 |
| Di Marzo, V; Howlett, TA; Marino, G; Morris, HR; Palmisano, A; Tomlin, S | 1 |
| Colpaert, FC; Członkowski, A; Herz, A; Höllt, V; Millan, MH; Millan, MJ; Pilcher, CW | 1 |
| Mihara, S; North, RA | 1 |
| Borson-Chazot, F; Jordan, D; Mornex, R; Veisseire, M | 1 |
| Kirby, GC; McQueen, DS | 1 |
| Sabol, SL; Yoshikawa, K | 2 |
| Grimes, L; Hong, JS; Kanamatsu, T; McGinty, JF; Obie, J; Sabol, S; Yoshikawa, K | 1 |
| Kwok, YN; McIntosh, HS; Nishimura, E | 1 |
| Cheng, CH; Hon, WK; Ng, TB; Su, BX | 1 |
| Castanas, E; Cazalis, M; Dayanithi, G; Giraud, P; Legros, JJ; Louis, F; Nordmann, JJ | 1 |
| Assanah, P; Ford, R; Harper, J; Jackson, DM; Leung, MK; Stefano, GB; Tetrault, L; Torres, JC | 1 |
| Dyer, RS; Hong, JS; Kanamatsu, T; McGinty, JF; Mitchell, CL; Obie, J | 1 |
| Acker, GR; Molineaux, C; Orlowski, M | 1 |
| Akita, K; Hatanaka, H; Maruyama, M; Sugino, H | 1 |
| Camargo, AC; Metters, KM; Oliveira, EB; Rossier, J; Toffoletto, O | 2 |
| Członkowski, A; Herz, A; Millan, MH; Millan, MJ | 1 |
| Fukuda, H; Oka, J; Suzuki, T | 1 |
| Gaymann, W; Martin, R | 1 |
| Ahmad, S; Allescher, HD; Daniel, EE; Fox, JE; Kostolanska, F | 1 |
| Cameron, DJ | 1 |
| Jenner, P; Marsden, CD | 1 |
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| Camberis, M; Hook, S; Konig, M; Le Gros, G; Prout, M; Van Heeke, G; Zimmer, A | 1 |
| Hook, VY; Hwang, SR; Rattan, J; Sei, CA; Steineckert, B; Toneff, T; Yasothornsrikul, S | 1 |
| Azuma, M; Houchi, H; Ikehara, T; Minakuchi, K; Shono, F; Tamaki, T; Umeda, T; Yoshizumi, M | 1 |
| Chien, GL; Takasaki, Y; van Winkle, DM; Wolff, RA | 1 |
| Kawabata, K | 1 |
| Haq, W; Katti, SB; Madhusudanan, KP; Misra, PK | 1 |
| Ibuki, T; Pappas, GD; Unnerstall, JR; Wang, H; Wang, XT | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Elde, RP; Hauser, KF; Houdi, AA; Maxson, W; Turbek, CS | 1 |
| Callahan, P; Janik, J; Klosterman, S; Prunty, D; Tompkins, J | 1 |
| Bogomaz, SA; Lishmanov, IuB; Maslov, LN; Tam, SV | 1 |
| Jiang, CL; Liu, XY; Lu, CL; Wang, YX; Xu, D; You, ZD | 1 |
| Danielson, P; Dores, RM; Joss, JM; Sollars, C | 1 |
| Huh, SO; Kim, YH; Song, DK; Suh, HW | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Miletić, T; Radulović, J; Stanojević, S; Vujić-Redzić, V | 1 |
| Aunis, D; Benson, H; Bilfinger, TV; Fricchione, GL; Goumon, Y; Metz-Boutigue, MH; Salzet, M; Stefano, GB; Tasiemski, A | 1 |
| Barron, BA; Caffrey, JL; Lakatta, EG; Pepe, S; Spurgeon, HA; Younès, A | 1 |
| Gustavsson, L; Nylander, I; Ploj, K; Roman, E | 1 |
| Danielson, P; Dores, RM; Lee, J; Lihrmann, I; Sollars, C; Vallarino, M; Vaudry, H | 1 |
| Drolet, G; McHugh, K; Menko, AS; Peoples, J; Van Bockstaele, EJ | 1 |
| Bornstein, SR; Böttner, A; Chrousos, GP; Eisenhofer, G; Haidan, A; Hiroi, N; McCann, SM; Roffler-Tarlov, S; Tian, H | 1 |
| Salzet, M; Tasiemski, A | 1 |
| Reddy, PS | 1 |
| Gollub, RL; Hui, KK; Stefano, GB | 1 |
| Caffrey, JL; Farias, M; Jackson, K; Stanfill, A | 1 |
| Antunes bras, J; Becker, C; Bourgoin, S; Cesselin, F; Hamon, M; Lombard, M; Pohl, M | 1 |
| Banks, WA; Cohn, CS; Kastin, AJ; Plotkin, SR | 1 |
| Hung, K; Mizoguchi, H; Ohsawa, M; Tseng, LF; Wu, H | 1 |
| Kozicz, T; Lázár, G | 1 |
| Abe, K; Chikuma, T; Chyuma, T; Kato, M; Kushida, K; Shigenaga, T; Taguchi, K | 1 |
| Blehar, DJ; Carraway, RE; Dickson, EW; Heard, SO; Przyklenk, K; Steinberg, G | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE | 1 |
| Asai, T; Kaneko, A; Sakane, T; Suzuki, N; Takeba, Y | 1 |
| Caffrey, JL; Farias, M; Jackson, KE; Stanfill, AS | 1 |
| Dircksen, H; Ollivaux, C; Soyez, D; Toullec, JY | 1 |
| Asai, M; Fernández-Guasti, A; Rodríguez-Manzo, G | 1 |
| Kozyrev, SA; Nikitin, VP; Shevelkin, AV | 2 |
| Caffrey, JL; Farias, M; Jackson, KE; Stanfill, A | 1 |
| Dlaboga, D; Dziedzicka-Wasylewska, M; Pierzchała-Koziec, K; Rogóz, Z | 1 |
| Duchemin, AM; Hadjiconstantinou, M; Isola, R; Neff, NH; Tejwani, GA; Zhang, H | 1 |
| Brehmer, A; Neuhuber, W; Schrödl, F | 1 |
| Bergeron, JJ; Bonneil, E; Li, J; Thibault, P; Tremblay, TL | 1 |
| Diamond, S; Mosnaim, AD; Puente, J; Saavedra, R; Wolf, ME | 1 |
| Gabryel, B; Herman, ZS; Kowalski, J; Łabuzek, K | 1 |
| Psurek, A; Scriba, GK | 1 |
| Fürtös-Matei, A; Hémond, C; Waldron, KC | 1 |
| Bogacka, I; Kaminski, T; Okrasa, S; Przala, J; Siawrys, G | 1 |
| Göcze, PM; Környei, JL; Kovács, KA; Vértes, M; Vértes, Z | 1 |
| Garduño-Juárez, R; Morales, LB | 1 |
| Nylander, I; Ploj, K; Roman, E | 1 |
| Bohr, HG; Jensen, MØ; Nielsen, BG | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Miletić, T; Radulović, J; Stanojević, S; Vujić, V | 1 |
| Bhatia, SC; Nayar, U; Saha, SN | 1 |
| Alrubaian, J; Danielson, P; Dores, RM; Joss, JM; Lecaude, S; Lee, J; Lihrman, I; Sollars, C; Vaudry, H | 1 |
| Cox, ML; Welch, SP | 1 |
| Hong, Y; Huang, H; Zeng, X | 1 |
| Clithero, AD; Leitermann, RJ; Sun, HS; Terashvili, M; Tseng, LF; Wu, HE | 1 |
| Holt, AG; Newman, SW | 1 |
| Cai, X; Dass, C | 1 |
| Bansal, V; Fahim, M; Hanif, K; Pasha, S; Pavar, MC | 1 |
| Baseski, HM; Cellar, NA; Kennedy, RT; Shackman, JG; Watson, CJ | 1 |
| Goldstein, JM; Malick, JB | 1 |
| Buschnack, SH; Kremmer, S; Muth-Selbach, U; Selbach, JM; Steuhl, KP | 1 |
| Christie, MJ; Connor, M; Marinelli, S; Schnell, SA; Vaughan, CW; Wessendorf, MW | 1 |
| Besson, MJ; Daugé, V; Durand, C; Giros, B; Penit-Soria, J; Vazquez, V | 1 |
| Lisi, TL; Sluka, KA | 1 |
| Caffrey, JL; Lakatta, EG; Pepe, S; Yoshishige, D; Younès, A | 1 |
| Tsogoev, AS | 1 |
| Sinnaeve, BA; Storme, ML; Van Bocxlaer, JF | 1 |
| Banks, WA; Farr, SA; Gaskin, FS; Hileman, SM; Jaeger, LB; Kumar, VB; Llanza, NV; Morley, JE; Urayama, A | 1 |
| Baugh, MM; Bradford, CS; Moore, FL; Stanley, DJ; Walthers, EA | 1 |
| Garey, LJ; Mensah-Brown, EP | 1 |
| Matysik, FM; Psurek, A; Scriba, GK | 1 |
| Gustafsson, L; Meyerson, BJ; Nylander, I; Ploj, K; Roman, E | 1 |
| Begotka, BA; Hunsader, JL; Morris, KF; Oparaeche, C; Vincent, JK | 1 |
| Chevalier, B; Drolet, G; Laforest, S; Poulin, JF | 1 |
| Pappas, GD; Qu, T; Sugaya, I; Sugaya, K | 1 |
| Assis, MA; Cancela, LM; Collino, C; Figuerola, Mde L; Sotomayor, C | 1 |
| Misra, N; Prasad, O; Sinha, L | 1 |
| Chen, JM; Lin, BC; Liu, WY; Xu, HT; Yang, J; Yang, Y | 2 |
| Bobrowski, K; Chatgilialoglu, C; Ferreri, C; Mozziconacci, O | 1 |
| Aşkin, A; Camlica, Y; Cömelekoğlu, U | 1 |
| Horvat, S; Jakas, A | 1 |
| Xi, C; Zeng, SJ; Zhang, XW; Zuo, MX | 1 |
| Jutkiewicz, EM | 1 |
| Kiguchi, N; Kishioka, S; Maeda, T; Ozaki, M; Tsuruga, M; Yamamoto, A; Yamamoto, C | 1 |
| Chen, G; Guo, L; Jiang, Y; Lin, JM; Qiu, B; You, Z | 1 |
| Chin, J; Meilandt, WJ; Mucke, L; Palop, JJ; Roberson, ED; Scearce-Levie, K; Wu, T; Yu, GQ | 1 |
| Fletcher, HJ; Stenken, JA | 1 |
| Barontini, M; Cigorraga, SB; Figuerola, Mde L; Levin, G; Pellizzari, EH | 1 |
| Fukuda, T; Hirota, M; Hitomi, J; Hoshi, N; Kusakabe, T; Suzuki, T | 1 |
| Le, W; Ondo, WG; Walters, AS; Zhu, W | 1 |
| Bolte, C; Newman, G; Schultz, Jel J | 1 |
| Kennedy, RT; Li, Q; Zubieta, JK | 1 |
| Hino, M; Horiuchi, H; Morino, T; Ogata, T; Yamamoto, H | 1 |
| Chu, J; Lin, BC; Liu, WY; Wang, G; Xu, H; Yang, J; Yang, Y; Yuan, H | 1 |
| Galeazzi, R; Lattanzi, R; Marcucci, E; Martelli, G; Negri, L; Orena, M; Rinaldi, S | 1 |
| Kelly, RT; Marginean, I; Page, JS; Smith, RD; Tang, K | 1 |
| Bourgoin, S; Cesselin, F; Hamon, M; Le Bars, D; Mauborgne, A | 1 |
| Brozyna, AA; Granese, J; Pisarchik, A; Slominski, AT; Szczesniewski, A; Tobin, DJ; Zbytek, B; Zmijewski, MA | 1 |
| Babos, F; Benyhe, S; Bojnik, E; Borsodi, A; Boynik, E; Corbani, M; Magyar, A | 1 |
| Chai, C; Qiu, C; Wang, W; Wang, Y; Xu, N; Yan, Y; Zhu, D | 1 |
| Hao, F; Li, P; Liang, JY; Pan, YJ; Qiu, PY; Wang, DX; Yang, J; Zhang, J | 1 |
| Kennedy, RT; Li, Q; Mabrouk, OS; Song, P | 1 |
| Bagosi, Z; Csabafi, K; Jászberényi, M; Telegdy, G; Tóth, G; Wollemann, M | 1 |
| Gautham, N; Ramya, L | 1 |
| d'Amora, M; Dores, RM; Vallarino, M | 1 |
| Karatayev, O; Leibowitz, SF; Liang, S; Morganstern, I; Ye, Z | 1 |
| Agirregoitia, E; Candenas, L; Cejudo-Roman, A; Irazusta, J; Pinto, FM; Subirán, N | 1 |
| Bournival, V; Dory, YL; Gendron, L; Proteau-Gagné, A; Rochon, K | 1 |
| Bachar, T; Fridkin, M; Heldman, E; Popov, M; Sasson, K; Shechter, Y | 1 |
| Guo, ZL; Li, M; Longhurst, JC; Tjen-A-Looi, SC | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
| Borst, DW; Ganji, PN; Kumar, S; Nagaraju, GP; Song, H; von Kalm, L | 1 |
| Kennedy, RT; Mabrouk, OS; Zhou, Y | 1 |
| Inoue, K; Murphy, AZ; Victoria, NC; Young, LJ | 1 |
| Demesmay, C; Dugas, V; El-Debs, R; Marechal, A | 1 |
| Pawlak, T; Potrzebowski, MJ | 1 |
| Barson, JR; Chen, A; Chen, YW; Hoebel, BG; Leibowitz, SF | 1 |
| Asai, M; Benítez-King, G; Escobar, C; Solís-Chagoyán, H; Valdés-Tovar, M | 1 |
| Bush, JA; DuPont, WH; Dziados, JE; Flanagan, SD; Fragala, MS; Gordon, SE; Hooper, DR; Kraemer, WJ; Looney, DP; Marchitelli, LJ; Patton, JF; Szivak, TK; Triplett, NT | 1 |
| Bosi, G; Giari, L; Sayyaf Dezfuli, B; Shinn, AP | 1 |
| Li, D; Li, H | 1 |
| Appleyard, CB; Cruz, ML; Flores, I; Hernández, S; Hernández-López, A; Palermo, K; Thompson, KJ; Torres-Reverón, A | 1 |
| Coveñas, R; Díaz-Cabiale, Z; Manso, B; Narváez, JA; Rivada, E; Salinas, P; Sánchez, ML; Smith, V | 1 |
| Calero, A; Evinger, M; Giri, P; Powers, JF; Tischler, AS; Villanueva, H | 1 |
| Fichna, J; Giełdoń, A; Kamysz, E; Sobocińska, M | 1 |
| Barroso, B; Meijer, J; Ozalp, A; van den Beld, C | 1 |
| Dyniewicz, J; Fichna, J; Misicka, A; Sobolewska-Włodarczyk, A; Somogyi, Á; Tymecka, D; Wilenska, B; Wiśniewska-Jarosińska, M; Włodarczyk, M | 1 |
| Batinić, J; Bjeliš, N; Jakas, A; Mrkus, L | 1 |
| Bonito, AJ; Fukuyama, H; Imai, M; Matoba, T; Minohara, K; Morita, A; Odanaka, M; Ohkura, N; Sakaguchi, S; Shime, H; Tsuiji, M; Uraki, R; Watanabe, M; Yamazaki, S; Yasumizu, Y | 1 |
| Liu, X; Ma, M; Wang, K; Wang, R; Wang, Y; Wei, S; Zhang, X; Zhao, L; Zhou, J | 1 |
| Grace, PM; Heijnen, CJ; Junigan, JM; Kavelaars, A; Trinh, R; Zhang, J | 1 |
| Alvarez, VA; Blegen, MB; Bocarsly, ME; Choi, IB; Dai, KZ; Dobbs, LK; Kaplan, AR; Kellendonk, C; Levitt, R; Matsui, A; Shin, JH; Simpson, EH | 1 |
| Chen, D; Fang, Q; Hu, X; Li, N; Shi, Y; Xu, B; Zhang, M; Zhang, N; Zhang, Q; Zhang, R | 1 |
| Schiller, PW; St-Hilaire, J | 1 |
| Averlant-Petit, MC; Benyhe, S; Bojnik, E; Chung, NN; Hernandez, JF; Legrand, B; Martinez, J; Mauchauffée, E; Schiller, PW; Touati-Jallabe, Y | 1 |
| Arévalo, JC; Arsequell, G; Barreto-Valer, K; Calle, LP; Gonzalez-Nunez, V; Jiménez-Barbero, J; Marcelo, F; Rodríguez, RE; Rosa, M; Sánchez-Sánchez, J; Valencia, G | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
22 review(s) available for enkephalin, leucine and enkephalin, methionine
| Article | Year |
|---|---|
Neuropeptides and Parkinson's disease.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Hormones; Humans; Neuropeptides; Parkinson Disease; Somatostatin; Substance P | 1986 |
Functional response of multiple opioid systems to chronic arthritic pain in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arthritis; Arthritis, Experimental; Benzomorphans; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Morphine; Naloxone; Nociceptors; Pain; Pituitary Gland, Anterior; Protein Precursors; Pyrrolidines; Rats; Receptors, Opioid; Sensory Thresholds; Spinal Cord; Thalamus | 1986 |
Peripheral actions of opiates in canine gastrointestinal tract: actions on nerves and muscles.
Topics: Animals; Cell Membrane; Digestive System; Dogs; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gastrointestinal Motility; Histocytochemistry; Immunochemistry; Intestine, Small; Motilin; Muscles; Narcotics; Receptors, Opioid; Stomach | 1987 |
Chronic pharmacological manipulation of dopamine receptors in brain.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Brain; Bromocriptine; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Levodopa; Pergolide; Receptors, Dopamine; Trifluoperazine | 1987 |
Opioids and breathing.
Topics: Adult; Anesthesia; Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; GABA Antagonists; Humans; Hypoxia; Morphine; Naloxone; Narcotics; Pulmonary Circulation; Respiration; Smoking | 1985 |
Neuroendocrinology of opioid peptides and their role in the control of gonadotropin and prolactin secretion.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Cushing Syndrome; DNA, Recombinant; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Gonadotropins; Humans; Hypothalamus; Luteinizing Hormone; Menstrual Cycle; Naloxone; Ovary; Pituitary Hormone-Releasing Hormones; Prolactin; Receptors, Opioid | 1985 |
[Enkephalinergic regulation of cardiovascular centers].
Topics: Animals; Blood Pressure; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Dextromoramide; Dogs; Enkephalin, Methionine; Enkephalins; Heart Rate; Medulla Oblongata; Naloxone; Naltrexone; Nervous System Physiological Phenomena; Pressoreceptors; Rats; Receptors, Opioid; Reflex; Reticular Formation; Sympathetic Nervous System; Vagus Nerve; Vasomotor System | 1985 |
Structural & biological studies of the acetaldehyde adducts of enkephalins and related peptides: a short review.
Topics: Acetaldehyde; Alcoholism; Animals; Binding Sites; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Magnetic Resonance Spectroscopy; Oligopeptides; Structure-Activity Relationship | 1985 |
[The coexistence of neuropeptides and catecholamines in the adrenal gland. Research on paracrine effects on adrenal cortex cells].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Amphibians; Angiotensin II; Animals; Anura; Catecholamines; Chromaffin Granules; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Histocytochemistry; Humans; Immunologic Techniques; Mammals; Nerve Tissue Proteins; Pheochromocytoma; Protein Precursors; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1984 |
Central distribution of opioid peptides.
Topics: Animals; Basal Ganglia; beta-Endorphin; Central Nervous System; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; Neural Pathways; Neurons; Rats; Spinal Cord; Subcellular Fractions; Synapses; Tissue Distribution; Trigeminal Nucleus, Spinal | 1983 |
The role of opioid peptides in memory and learning.
Topics: Amnesia; Animals; beta-Endorphin; Brain; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Learning; Memory; Naloxone; Naltrexone; Norepinephrine; Rats | 1980 |
Adrenal-pituitary axis and the opiate system; corticosteroid-adrencorticotropic hormones and the opiate system.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alcohol Drinking; Analgesia; Animals; Appetite; beta-Endorphin; Brain Chemistry; Circadian Rhythm; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Feedback; Humans; Mice; Pituitary-Adrenal System; Rats; Receptors, Opioid; Stress, Physiological | 1983 |
Endorphins and exercise.
Topics: Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Growth Hormone; Hormones; Humans; Male; Naloxone; Norepinephrine; Physical Exertion; Prolactin; Renin | 1984 |
[The co-localization of monoamines and enkephalins in the central nervous system].
Topics: 5,6-Dihydroxytryptamine; 5,7-Dihydroxytryptamine; Amines; Animals; Brain; Catecholamines; Cats; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Histocytochemistry; Hydroxydopamines; Hypothalamus; Immunologic Techniques; Locus Coeruleus; Neurons; Norepinephrine; Oxidopamine; Protein Precursors; Raphe Nuclei; Rats; Serotonin; Tissue Distribution | 1984 |
Physiological role of endorphins in neuroendocrinology.
Topics: Aging; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Estrus; Female; Growth Hormone; Hypothalamus; Male; Pregnancy; Prolactin; Rats; Serotonin; Stimulation, Chemical | 1981 |
Vertebrate brain-gut peptides related to FMRFamide and Met-enkephalin Arg6Phe7.
Topics: Animals; Antibody Specificity; Anura; Brain; Cattle; Chickens; Digestive System; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; FMRFamide; Guinea Pigs; Helix, Snails; Histocytochemistry; Humans; Immunologic Techniques; Oligopeptides; Pancreas; Radioimmunoassay; Rats; Tissue Distribution | 1981 |
[Enkephalin-inactivating enzymes].
Topics: Aminopeptidases; Animals; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Receptors, Opioid; Vas Deferens | 1993 |
[Met5-enkephalin, Leu5-enkephalin].
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Humans | 1999 |
Involvement of pro-enkephalin-derived peptides in immunity.
Topics: Animals; Anti-Infective Agents; Enkephalin, Methionine; Enkephalins; Humans; Inflammation; Inflammation Mediators; Invertebrates; Protein Precursors; Vertebrates | 2001 |
Acupuncture: pain management coupled to immune stimulation.
Topics: Acupuncture Analgesia; Animals; Anti-Infective Agents; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Pain Threshold; Peptide Fragments; Somatosensory Cortex | 1999 |
[Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk)].
Topics: Adrenal Gland Neoplasms; Alcoholism; Cerebral Infarction; Craniocerebral Trauma; Diagnostic Techniques, Endocrine; Enkephalin, Leucine; Enkephalin, Methionine; Heroin Dependence; Humans; Kidney Failure, Chronic; Pheochromocytoma; Radioimmunoassay; Reference Values; Specimen Handling | 2005 |
RB101-mediated protection of endogenous opioids: potential therapeutic utility?
Topics: Aminopeptidases; Animals; Cholecystokinin; Disulfides; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Mice; Phenylalanine; Prodrugs; Rats | 2007 |
7 trial(s) available for enkephalin, leucine and enkephalin, methionine
| Article | Year |
|---|---|
The acute effects of the enkephalin analogue BW 942C in humans.
Topics: Adult; Antidiarrheals; Double-Blind Method; Emotions; Enkephalin, Methionine; Enkephalins; Follicle Stimulating Hormone; Growth Hormone; Humans; Infusions, Intravenous; Luteinizing Hormone; Male; Prolactin; Respiratory Function Tests | 1987 |
Control of chemotherapy-induced diarrhea with the synthetic enkephalin BW942C: a randomized trial with placebo in patients receiving cisplatin.
Topics: Adult; Antidiarrheals; Cisplatin; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Enkephalin, Methionine; Enkephalins; Female; Humans; Male; Middle Aged; Neoplasms; Placebos; Random Allocation | 1988 |
Role of a novel antidiarrheal agent, BW942C, alone or in combination with trimethoprim-sulfamethoxazole in the treatment of traveler's diarrhea.
Topics: Antidiarrheals; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Drug Combinations; Enkephalin, Methionine; Enkephalins; Feces; Female; Humans; Male; Mexico; Random Allocation; Sulfamethoxazole; Travel; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; United States | 1986 |
Analgesic efficacy of parenteral metkephamid acetate in treatment of postoperative pain.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Injections, Intramuscular; Meperidine; Middle Aged; Pain, Postoperative; Random Allocation | 1982 |
Inhibition of vasopressin secretion by a met-enkephalin (FK 33-824) in humans.
Topics: Adult; Body Water; Clinical Trials as Topic; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Kidney; Lypressin; Male; Middle Aged; Naloxone; Prolactin; Receptors, Opioid; Vasopressins | 1980 |
Chlorpropamide alcohol flush and circulating met-enkephalin: a positive link.
Topics: beta-Endorphin; Chlorpropamide; Diabetes Mellitus; Double-Blind Method; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Erythema; Face; Female; Humans; Male; Wine | 1981 |
Changes in pituitary hormone levels induced by met-enkephalin in man--the role of dopamine.
Topics: Adult; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Domperidone; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Follicle Stimulating Hormone; Growth Hormone; Humans; Hydrocortisone; Luteinizing Hormone; Male; Pituitary Hormones; Prolactin; Thyrotropin | 1981 |
1468 other study(ies) available for enkephalin, leucine and enkephalin, methionine
| Article | Year |
|---|---|
Nuclear-magnetic-resonance study on Met-enkephalin and Met-enkephalinamide. Molecular association and conformation.
Topics: Circular Dichroism; Endorphins; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Protein Conformation; Structure-Activity Relationship | 1979 |
Central nervous system mediated stimulation by thyrotropin-releasing hormone of microcirculation in thyroid gland of rats.
Topics: Adrenal Cortex; Animals; Central Nervous System; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Kidney Cortex; Male; Microcirculation; Rats; Thyroid Gland; Thyrotropin-Releasing Hormone | 1979 |
Possible non-narcotic component to action of opiate peptides on tonic immobility.
Topics: Animals; Animals, Newborn; Chickens; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorocarbons; Hormones; Motor Activity; Naloxone | 1979 |
[Monoaminergic modulation of the analgesia induced in rats by (D-Ala2)-met-enkephalinamide (DADA)].
Topics: Analgesics; Animals; Biogenic Amines; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Monoamine Oxidase Inhibitors; Morphine; Rats | 1979 |
[A liquid phase synthesis of enkephalins (author's transl)].
Topics: Animals; Chromatography; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mice | 1979 |
Decrease of enkephalins in cerebellum during Wobbler mouse motoneuron disease.
Topics: Aging; Animals; Cerebellum; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Substance P; Thyrotropin-Releasing Hormone | 1992 |
Perinatal morphine exposure alters peptidergic development in the striatum.
Topics: Animals; Blotting, Northern; Body Weight; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Growth; Immunohistochemistry; In Situ Hybridization; Morphine; Naloxone; Naltrexone; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P | 1992 |
[The effect of synthetic enkephalins on prostaglandin synthesis and lipid peroxidation in the isolated heart during the activation of free-radical processes].
Topics: Animals; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Free Radicals; Heart; In Vitro Techniques; Lipid Peroxidation; Myocardium; Prostaglandins; Rats; Thromboxanes | 1992 |
Effect of serotonin and opiate peptides on ion-currents of dialysed Helix neurons.
Topics: Animals; Calcium; Enkephalin, Leucine; Enkephalin, Methionine; Helix, Snails; Ion Transport; Neurons; Potassium; Serotonin | 1992 |
Pre- and postsynaptic inhibition by opioids in rat striatum.
Topics: Action Potentials; Animals; Corpus Striatum; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Male; Membrane Potentials; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synapses | 1992 |
Expression of prepro-enkephalin in human articular chondrocytes is linked to cell proliferation.
Topics: Base Sequence; Bucladesine; Cartilage, Articular; Cell Division; Cells, Cultured; Dexamethasone; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Growth Substances; Humans; Interleukin-1; Molecular Sequence Data; Protein Precursors; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tretinoin; Up-Regulation | 1992 |
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil | 1992 |
Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.
Topics: Analgesics; beta-Endorphin; Cell Survival; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; Indoles; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity.
Topics: Analgesics; Animals; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Distinct receptors for Leu- and Met-enkephalin on the metacerebral giant cell of Aplysia.
Topics: Action Potentials; Amino Acid Sequence; Animals; Aplysia; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; FMRFamide; Molecular Sequence Data; Neurons; Neuropeptides; Receptors, Opioid | 1992 |
Met- and Leu-enkephalin modulate superoxide anion release from human polymorphonuclear cells.
Topics: Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Naloxone; Neutrophils; Respiratory Burst; Superoxides | 1992 |
Inhibitory effects of proopiomelanocortin on cortical and medullary activity in the calf adrenal.
Topics: Adrenal Cortex; Adrenal Medulla; Adrenocorticotropic Hormone; Animals; Cattle; Cosyntropin; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hydrocortisone; Hypophysectomy; Pro-Opiomelanocortin; Protein Precursors | 1992 |
The effect of fetal hypophysectomy with or without ACTH replacement on the molecular weight profile of enkephalin-containing peptides in the adrenal medulla of the fetal sheep.
Topics: Adrenal Medulla; Adrenocorticotropic Hormone; Animals; Enkephalin, Methionine; Enkephalins; Fetus; Hypophysectomy; Molecular Weight; Protein Precursors; Radioimmunoassay; Sheep | 1992 |
Opioid receptor agonists and Ca2+ modulation in human B cell lines.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; B-Lymphocytes; Benzeneacetamides; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Humans; Naloxone; Pyrrolidines; Receptors, Opioid; Signal Transduction | 1992 |
Antisense proenkephalin cDNA transfection decreases opioid binding in NG 108-15 cells.
Topics: Base Sequence; DNA, Antisense; Endorphins; Enkephalin, Methionine; Enkephalins; Hybrid Cells; Molecular Sequence Data; Plasmids; Protein Binding; Protein Precursors; Radioligand Assay; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1992 |
Enkephalin hydrolysis by mouse plasma in vitro.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; CD13 Antigens; Chromatography, High Pressure Liquid; Electrochemistry; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Male; Mice; Molecular Sequence Data; Neprilysin; Peptidyl-Dipeptidase A; Plasma; Time Factors | 1992 |
Opioids excite dopamine neurons by hyperpolarization of local interneurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Bicuculline; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Mesencephalon; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses | 1992 |
Influence of opioids on CSF vasopressin concentration in newborn pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analysis of Variance; Animals; Animals, Newborn; beta-Endorphin; Cerebral Arteries; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Naloxone; Pyrrolidines; Swine; Vasopressins | 1992 |
[Changes in the contents of peptides in the sensory-motor cortex of rats in response to post-stimulation convulsive discharges].
Topics: Animals; Electric Stimulation; Electrophysiology; Enkephalin, Leucine; Enkephalin, Methionine; Male; Motor Cortex; Neuropeptides; Rats; Seizures; Somatosensory Cortex; Somatostatin | 1992 |
The influence of opioids on local cerebral glucose utilization in the newborn pig.
Topics: Animals; Animals, Newborn; Autoradiography; Brain; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Glucose; Swine; Tissue Distribution | 1992 |
Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations.
Topics: Animals; Brain; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Radioimmunoassay; Stress, Physiological | 1992 |
Lateral hypothalamic area neurotransmission and neuromodulation of the specific cardiac effects of insular cortex stimulation.
Topics: Animals; Cerebral Cortex; Cobalt; Dynorphins; Electric Stimulation; Electrocardiography; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Heart Rate; Hypothalamic Area, Lateral; Kynurenic Acid; Male; Neuropeptide Y; Rats; Rats, Inbred Strains; Synaptic Transmission | 1992 |
Developmental expression of the proenkephalin and prosomatostatin genes in cultured cortical and cerebellar astrocytes.
Topics: Aging; Animals; Astrocytes; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA Probes; Enkephalin, Methionine; Enkephalins; Fetus; Gene Expression; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA, Messenger; Somatostatin | 1992 |
Enkephalin biosynthesis is coupled to secretory activity via transcription of the proenkephalin A gene.
Topics: Adrenal Glands; Animals; Base Sequence; Calcium; Calcium Channels; Cattle; Cells, Cultured; Chromaffin System; Chromogranins; Electrophysiology; Enkephalin, Methionine; Enkephalins; Hexamethonium; Hexamethonium Compounds; Molecular Sequence Data; Potassium Chloride; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger; Sequence Homology; Transcription, Genetic | 1992 |
Early complete maturation of proenkephalin processing induced by dexamethasone in the adrenal gland of neonatal rats.
Topics: Adrenal Glands; Animals; Animals, Newborn; Carbachol; Chromatography; Dexamethasone; Enkephalin, Methionine; Enkephalins; Humans; Infant, Newborn; Nicotine; Pilocarpine; Protein Precursors; Rats; Reserpine | 1992 |
Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (Papio papio).
Topics: Animals; Calcitonin Gene-Related Peptide; Cordotomy; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; Male; Microscopy, Electron; Neurons, Afferent; Neuropeptides; Norepinephrine; Papio; Serotonin; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone; Urination | 1992 |
Neuropeptidergic innervation of intramuscular hemangiomas.
Topics: Adolescent; Adult; Calcitonin Gene-Related Peptide; Child; Enkephalin, Leucine; Enkephalin, Methionine; Hemangioma; Humans; Immunohistochemistry; Muscles; Muscular Diseases; Nerve Fibers; Neuropeptides; S100 Proteins; Soft Tissue Neoplasms; Substance P; Vasoactive Intestinal Peptide | 1992 |
N-methyl-D-aspartate receptor antagonism alters substance P and met5-enkephalin biosynthesis in neurons of the rat striatum.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Male; N-Methylaspartate; Neurons; Piperazines; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance P; Tachykinins; Valine | 1992 |
Measurement of beta-endorphin in human plasma by high-performance liquid chromatography with electrochemical detection: validation of a method employing the simultaneous purification and concentration of beta-endorphin.
Topics: Aprotinin; beta-Endorphin; Chromatography, High Pressure Liquid; Electrochemistry; Enkephalin, Leucine; Enkephalin, Methionine; Heparin; Humans; Reproducibility of Results; Temperature | 1992 |
Alteration in the levels of thyrotropin releasing hormone, substance P and enkephalins in the spinal cord, brainstem, hypothalamus and midbrain of the Wobbler mouse at different stages of the motoneuron disease.
Topics: Animals; Brain Stem; Chromatography, Gel; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Mesencephalon; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Organ Specificity; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1992 |
Effects of a unilateral 6-hydroxydopamine lesion and prolonged L-3,4-dihydroxyphenylalanine treatment on peptidergic systems in rat basal ganglia.
Topics: Animals; Carbidopa; Cholecystokinin; Chromatography, High Pressure Liquid; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Levodopa; Male; Neuropeptides; Neurotensin; Oxidopamine; Prosencephalon; Rats; Rats, Wistar; Substance P; Substantia Nigra | 1992 |
Release of immunoreactive enkephalinergic substances in the periaqueductal grey of the cat during fatiguing isometric contractions.
Topics: Animals; Cats; Enkephalin, Methionine; Enkephalins; Fatigue; Heart Rate; Hindlimb; Isometric Contraction; Periaqueductal Gray | 1992 |
Oxytocin blocks the development of heroin-enkephalin cross-tolerance in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Nociceptors; Oxytocin; Pain Measurement; Reaction Time | 1992 |
Species variability in the expression of met- and leu-enkephalin-like immunoreactivity in mammalian Merkel cell dense-core granules. A light- and electron-microscopic immunohistochemical study.
Topics: Animals; Cats; Cricetinae; Cytoplasmic Granules; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Hair; Immunohistochemistry; Male; Mice; Microscopy, Immunoelectron; Rabbits; Species Specificity | 1992 |
Effects of the subcutaneous administration of enkephalins on tail-flick response and righting reflex of developing rats.
Topics: Aging; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Glycopeptides; Injections, Subcutaneous; Male; Oligopeptides; Pain; Peptides; Posture; Protease Inhibitors; Rats; Rats, Wistar; Reflex | 1992 |
Prolonged stimulation of bovine adrenal chromaffin cells with arachidonic acid and prostaglandin E2 increases expression of the proenkephalin gene and the secretion of [Met5]-enkephalin.
Topics: Adrenal Medulla; Animals; Arachidonic Acid; Cattle; Cells, Cultured; Chromaffin System; Cycloheximide; Dinoprostone; Enkephalin, Methionine; Enkephalins; Gene Expression; Prodrugs; Protein Biosynthesis; RNA, Messenger | 1992 |
GABAergic afferents modulate proenkephalin mRNA expression in the guinea pig hypothalamic magnocellular dorsal nucleus.
Topics: Aminooxyacetic Acid; Animals; Dorsomedial Hypothalamic Nucleus; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Guinea Pigs; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Male; Neurons, Afferent; Protein Precursors; RNA, Messenger | 1992 |
Chronic naltrexone treatment of rats: effects on gastrointestinal opioid peptide content.
Topics: Animals; beta-Endorphin; Digestive System; Duodenum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Jejunum; Male; Naltrexone; Pyloric Antrum; Radioimmunoassay; Radioligand Assay; Rats; Rats, Wistar | 1992 |
Detection of Met-enkephalin in the pars intermedia of the lampreys, Ichthyomyzon castaneus and Petromyzon marinus.
Topics: Animals; Brain; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Lampreys; Pituitary Gland; Radioimmunoassay | 1992 |
Effect of centrally administered enkephalins on carrageenin-induced paw oedema in rats.
Topics: Animals; Arthritis, Experimental; Brain; Carrageenan; Edema; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hindlimb; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Injections, Intraventricular; Male; Metyrapone; Morphine; Naloxone; Pituitary-Adrenal System; Rats; Rats, Wistar | 1992 |
Effects of [Sar1]angiotensin II on proenkephalin gene expression and secretion of [Met5]enkephalin in bovine adrenal medullary chromaffin cells.
Topics: Adrenal Medulla; Angiotensin II; Animals; Base Sequence; Cattle; Cells, Cultured; Chromaffin System; Enkephalin, Methionine; Enkephalins; Gene Expression; Imidazoles; Intracellular Membranes; Molecular Probes; Molecular Sequence Data; Protein Precursors; Pyridines; RNA, Messenger | 1992 |
Enhancement of systemic delivery of met-enkephalin and leu-enkephalin eyedrops with permeation enhancers.
Topics: Absorption; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Excipients; Ophthalmic Solutions; Permeability; Polidocanol; Polyethylene Glycols; Rabbits; Radioimmunoassay | 1992 |
[A study of opioid peptides in synovial fluid and synovial tissue in patients with rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Stress, Psychological; Synovial Fluid; Synovial Membrane | 1992 |
Proenkephalin A derivatives in lacrimal gland: occurrence and regulation of lacrimal function.
Topics: Adenylyl Cyclases; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Lacrimal Apparatus; Male; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains | 1992 |
Enhancement by methionine- and leucine-enkephalin of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
Topics: Animals; Carcinoma; Cell Division; Drug Synergism; Enkephalin, Leucine; Enkephalin, Methionine; Gastric Mucosa; Gastrins; Hydrogen-Ion Concentration; Male; Methylnitronitrosoguanidine; Rats; Rats, Inbred Strains; Stomach Neoplasms | 1992 |
Immunohistochemistry of enkephalins: model studies on hapten-carrier conjugates and fixation methods.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Carbodiimides; Enkephalin, Methionine; Enkephalins; Female; Ganglia, Sympathetic; Glutaral; Haptens; Immunohistochemistry; Indicators and Reagents; Male; Mice; Microscopy, Immunoelectron; Molecular Sequence Data; Neurons; Pituitary Gland; Rabbits; Rats; Rats, Inbred Strains; Sequence Homology, Nucleic Acid; Spinal Cord | 1992 |
Combination of immunocytochemistry and in situ hybridization in the same semi-thin sections: detection of Met-enkephalin and pro-enkephalin mRNA in the hypothalamic magnocellular dorsal nucleus of the guinea pig.
Topics: Animals; Autoradiography; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hypothalamus; Immunohistochemistry; Male; Nucleic Acid Hybridization; Protein Precursors; RNA, Messenger | 1992 |
Occurrence of immunoreactive Met- and Leu-enkephalin-like peptides in the ovary of the green frog, Rana esculenta.
Topics: Animals; Cross Reactions; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fluorescent Antibody Technique; Ovary; Rana esculenta | 1992 |
A compact time-of-flight mass spectrometer for the structural analysis of biological molecules using laser desorption.
Topics: Coumaric Acids; Enkephalin, Methionine; Enkephalins; Lasers; Mass Spectrometry; Oligopeptides; Protein Precursors | 1992 |
Melanins production from enkephalins by tyrosinase.
Topics: Amino Acids; Basidiomycota; Chromatography, Ion Exchange; Enkephalin, Leucine; Enkephalin, Methionine; Kinetics; Melanins; Monophenol Monooxygenase; Oxidation-Reduction; Spectrophotometry; Substrate Specificity | 1992 |
Time-dependent changes in the activity of opioid systems in the spinal cord of monoarthritic rats--a release and in situ hybridization study.
Topics: Animals; Arthritis, Experimental; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Male; Nucleic Acid Hybridization; Oligonucleotide Probes; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA, Messenger; Spinal Cord; Sulfur Radioisotopes | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Prohormone thiol protease and enkephalin precursor processing: cleavage at dibasic and monobasic sites.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Enkephalin, Methionine; Enkephalins; Molecular Sequence Data; Peptide Biosynthesis; Peptides; Protein Precursors; Protein Processing, Post-Translational | 1992 |
Endogenous opioid peptides in brain and pituitary of rats with absence epilepsy.
Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Epilepsy, Absence; Male; Pituitary Gland; Protein Precursors; Rats; Rats, Inbred ACI; Rats, Inbred Strains | 1992 |
Endogenous opioids accumulate in plasma in a rat model of acute cholestasis.
Topics: Acute Disease; Amino Acid Sequence; Aminopeptidases; Animals; Cholestasis; Disease Models, Animal; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Male; Molecular Sequence Data; Rats; Rats, Inbred Strains | 1992 |
Enkephalin peptides in fetal sheep, changes with gestation, origin and production by the placenta.
Topics: Adrenal Glands; Animals; Enkephalin, Methionine; Enkephalins; Female; Fetal Blood; Fetus; Gestational Age; Hypoxia; Placenta; Pregnancy; Protein Precursors; Sheep; Sympathectomy | 1992 |
Calcium-dependent regulation of the enkephalin phenotype by neuronal activity during early ontogeny.
Topics: Animals; Calcium; Calcium Channel Blockers; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Gene Expression Regulation; Ion Channel Gating; Membrane Potentials; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Nicotinic Acids; Oxadiazoles; Phenotype; Protein Precursors; RNA, Messenger; Signal Transduction; Sodium Channels; Spinal Cord; Synaptic Transmission; Tetrodotoxin | 1991 |
Effects of oxymorphindole on morphine induced-antinociception in mice and rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mice; Morphine; Morpholines; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
The peroxidase-catalyzed oxidation of enkephalins.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Enkephalin, Leucine; Enkephalin, Methionine; Horseradish Peroxidase; Kinetics; Lactoperoxidase; Oxidation-Reduction; Peroxidase; Peroxidases; Spectrophotometry, Ultraviolet; Tyrosine | 1991 |
Preproenkephalin mRNA and enkephalin in normal and denervated adrenals in the Syrian hamster: comparison with central nervous system tissues.
Topics: Adrenal Glands; Adrenal Medulla; Animals; Brain; Cricetinae; Denervation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; Liver; Mesocricetus; Norepinephrine; Organ Specificity; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger | 1991 |
Opioid control of the release of Met-enkephalin-like material from the rat spinal cord.
Topics: Animals; Cerebrospinal Fluid; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Tetrodotoxin | 1991 |
Zeta (zeta), a growth-related opioid receptor in developing rat cerebellum: identification and characterization.
Topics: Animals; Animals, Newborn; Binding, Competitive; Cations; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Guanylyl Imidodiphosphate; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Subcellular Fractions; Temperature; Trypsin | 1991 |
Striatal proenkephalin turnover and gene transcription are regulated by cyclic AMP and protein kinase C-related pathways.
Topics: Animals; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Female; Immunohistochemistry; Neural Pathways; Neurons; Nucleic Acid Hybridization; Pregnancy; Protein Kinase C; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1991 |
An in vitro study on the hippocampal epileptogenic properties of enkephalins and enkephalinase inhibitors in rats.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Epilepsy; Hippocampus; In Vitro Techniques; Male; Morphine; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Aspects of the design of conformationally constrained peptides.
Topics: Amides; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Peptides; Protein Conformation; Protons; Software | 1991 |
Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro.
Topics: Analgesics; Animals; Animals, Newborn; Astrocytes; Benzeneacetamides; Cells, Cultured; DNA Replication; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Mice, Inbred ICR; Neuroglia; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thymidine | 1991 |
Identification of opioid receptors on gastric muscle cells by selective receptor protection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Stomach | 1991 |
Stereoselective effect of morphine on antinociception and endogenous opioid peptide levels in plasma but not cerebrospinal fluid of dogs.
Topics: Animals; Behavior, Animal; beta-Endorphin; Dogs; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Subcutaneous; Morphine; Nociceptors; Pain Measurement; Stereoisomerism; Tritium | 1991 |
Opioid inhibition of nicotine-induced 45Ca2(+)-uptake into cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Benzomorphans; Calcium; Cattle; Cells, Cultured; Chromaffin System; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Nicotine; Oligopeptides | 1991 |
Dopaminergic regulation of enkephalin release.
Topics: Animals; Brain; Corpus Striatum; Dopamine; Dopamine Agents; Enkephalin, Methionine; Enkephalins; Haloperidol; In Vitro Techniques; Male; Oligopeptides; Potassium; Rats; Rats, Inbred Strains | 1991 |
Opioids in cerebrospinal fluid in hypotensive newborn pigs.
Topics: Animals; Animals, Newborn; beta-Endorphin; Cerebral Arteries; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hemorrhage; Hypotension; Muscle, Smooth, Vascular; Radioimmunoassay; Radioligand Assay; Reference Values; Swine; Vasodilation | 1991 |
Acute effects of D-1 and D-2 dopamine receptor agonist and antagonist drugs on basal ganglia [Met5]- and [Leu5]-enkephalin and neurotensin content in the rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Basal Ganglia; Benzazepines; Chromatography, High Pressure Liquid; Dopamine Agents; Dopamine Antagonists; Enkephalin, Leucine; Enkephalin, Methionine; Ergolines; Male; Neurotensin; Quinpirole; Radioimmunoassay; Rats; Rats, Inbred Strains; Sulpiride | 1991 |
Effect of opioid peptides on circular muscle of canine duodenum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Muscles; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid | 1991 |
Evidence for enkephalin- and endorphin-immunoreactive cells in the anterior pituitary of the axolotl Ambystoma mexicanum.
Topics: Ambystoma mexicanum; Animals; Antibodies; beta-Endorphin; Cross Reactions; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Immunohistochemistry; Nerve Fibers; Pituitary Gland, Anterior | 1991 |
Inhibition by opioids of phagocytosis in peritoneal macrophages.
Topics: Animals; beta-Endorphin; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Erythrocytes; Macrophages; Mice; Morphine; Naloxone; Peritoneal Cavity; Phagocytosis; Sheep | 1991 |
Further characterization of the in vitro hydrolysis of [Leu]- and [Met]enkephalin in rat plasma: HPLC-ECD measurement of substrate and metabolite concentrations.
Topics: Amino Acids; Aminopeptidases; Animals; Captopril; CD13 Antigens; Chromatography, High Pressure Liquid; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Strains | 1991 |
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1991 |
Opioids can produce a concentration-dependent naloxone-reversible enhancement of inhibition of evoked enkephalin release.
Topics: Analgesics; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Naloxone; Narcotics; Parasympatholytics; Sufentanil; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Effect of opioid peptides on electrically evoked acetylcholine release from Torpedo electromotor neurons.
Topics: Acclimatization; Acetylcholine; Animals; Dynorphins; Electric Organ; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Motor Neurons; Naloxone; Seasons; Torpedo | 1991 |
Inhibition of peptidases potentiates enkephalin-stimulated contraction of gastric muscle cells.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Carbachol; CD13 Antigens; Enkephalin, Leucine; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Oligopeptides; Peptides; Protease Inhibitors; Recombinant Proteins; Stomach | 1991 |
An enkephalin degrading aminopeptidase of human brain preserved during the vertebrate phylogeny.
Topics: Amino Acid Sequence; Amino Acids; Aminopeptidases; Amphibians; Animals; Birds; Brain; Callithrix; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fishes; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Focusing; Molecular Sequence Data; Naphthalenes; Phylogeny; Rats; Reptiles; Tyrosine | 1991 |
IR-Met and IR-leu-enkephalin content in the perioesophageal ganglia of Helix aspersa seasonal variations.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Esophagus; Ganglia; Helix, Snails; Seasons | 1991 |
Neuropeptide content in pancreas and pituitary of obese and diabetes mutant mice: strain and sex differences.
Topics: Animals; beta-Endorphin; Diabetes Mellitus, Experimental; Enkephalin, Leucine; Enkephalin, Methionine; Female; Galanin; In Vitro Techniques; Insulin; Male; Mice; Mice, Mutant Strains; Mice, Obese; Neuropeptides; Obesity; Pancreas; Peptides; Pituitary Gland; Reference Values; Sex Factors; Species Specificity | 1990 |
Measurement of neuropeptides in the brain and spinal cord of Wobbler mouse: a model for motoneuron disease.
Topics: Aging; Animals; Brain; Brain Chemistry; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Mice; Mice, Neurologic Mutants; Motor Neurons; Neuromuscular Diseases; Neuropeptides; Somatostatin; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1990 |
Expression of proenkephalin A mRNA and enkephalin-containing peptides in cultured fibroblasts.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Enkephalin, Methionine; Enkephalins; Fibroblasts; Gene Expression; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; Restriction Mapping; RNA; RNA, Messenger | 1990 |
Proenkephalin products are stored in the sperm acrosome and may function in fertilization.
Topics: Acrosome; Animals; Antibodies, Monoclonal; Cricetinae; Enkephalin, Methionine; Enkephalins; Fertilization; Humans; Male; Poly A; Polyribosomes; Protein Precursors; Rats; RNA; RNA, Messenger; Spermatids; Spermatocytes; Spermatogenesis; Spermatozoa; Testis; Transcription, Genetic | 1990 |
Neuropeptide release from isolated myenteric nerve endings derived from the guinea pig myenteric plexus.
Topics: Animals; Atropine; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Myenteric Plexus; Naloxone; Nerve Endings; Neurokinin A; Neuropeptides; Substance P; Xanthines | 1990 |
Effects of [N-(L-(1-carboxy-2-phenyl)ethyl]-L-phenylalanyl-beta-alanine (SCH32615), a neutral endopeptidase (enkephalinase) inhibitor, on levels of enkephalin, encrypted enkephalins and substance P in cerebrospinal fluid and plasma of primates.
Topics: Animals; Dipeptides; Electrocardiography; Electroencephalography; Enkephalin, Methionine; Enkephalins; Female; Hemodynamics; Injections, Intravenous; Macaca fascicularis; Male; Neprilysin; Radioimmunoassay; Substance P | 1991 |
Neuropeptide-immunoreactive cells in human thymus.
Topics: beta-Endorphin; Cell Differentiation; Child, Preschool; Enkephalin, Leucine; Enkephalin, Methionine; Epithelium; Humans; Infant; Infant, Newborn; Intercellular Junctions; Neuroimmunomodulation; Neuropeptides; Substance P; T-Lymphocytes; Thymus Gland | 1990 |
Atrial natriuretic polypeptide secretion via selective activation of kappa-opioid receptor: role of dynorphin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzomorphans; Cells, Cultured; Diuretics; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart; Heart Atria; Kinetics; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Neuropeptide levels in the basal ganglia of aged common marmosets following prolonged treatment with MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Basal Ganglia; Biogenic Monoamines; Callithrix; Caudate Nucleus; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Female; Globus Pallidus; Homovanillic Acid; Male; Neuropeptides; Neurotensin; Putamen; Reference Values; Sincalide; Substance P | 1991 |
The regional distribution of thyrotropin releasing hormone, leu-enkephalin, met-enkephalin, substance P, somatostatin and cholecystokinin in the rat brain and pituitary.
Topics: Animals; Brain Chemistry; Brain Stem; Cholecystokinin; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hypothalamus; Male; Neuropeptides; Pituitary Gland; Rats; Rats, Inbred Strains; Somatostatin; Substance P; Thyrotropin-Releasing Hormone | 1991 |
The innervation of the human prostate gland--the changes associated with benign enlargement.
Topics: Acetylcholinesterase; Aged; Calcitonin Gene-Related Peptide; Dopamine beta-Hydroxylase; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Male; Nerve Fibers; Neuropeptide Y; Prostate; Prostatic Hyperplasia; Serotonin; Urinary Bladder Neck Obstruction; Vasoactive Intestinal Peptide | 1991 |
Isocratic reverse-phase HPLC separation and RIA used in the analysis of neuropeptides in brain tissue.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Male; Neuropeptides; Neurotensin; Radioimmunoassay; Rats; Rats, Inbred Strains; Sincalide; Substance P; Sulfates | 1991 |
Preproenkephalin A gene expression in rat pineal.
Topics: Animals; Blotting, Northern; Enkephalin, Methionine; Enkephalins; Gene Expression; Male; Pineal Gland; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA | 1991 |
Enkephalins, substance P and acetylcholine microinjected into the nucleus ambiguus elicit vagal bradycardia in rats.
Topics: Acetylcholine; Animals; Blood Pressure; Decerebrate State; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Heart Rate; Male; Medulla Oblongata; Microinjections; Neural Pathways; Rats; Rats, Inbred Strains; Substance P; Sympathetic Nervous System; Vagus Nerve | 1991 |
Immunohistochemical evidence for the coexistence of substance P, thyrotropin-releasing hormone, GABA, methionine-enkephalin, and leucin-enkephalin in the serotonergic neurons of the caudal raphe nuclei: a dual labeling in the rat.
Topics: Animals; Autoradiography; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Immunoenzyme Techniques; Immunohistochemistry; Iodine Radioisotopes; Male; Neurons; Radioimmunoassay; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Substance P; Thyrotropin-Releasing Hormone | 1991 |
Posttranslational processing of proenkephalin in SK-N-MC cells: evidence for phosphorylation.
Topics: Cell Line; Culture Media; Enkephalin, Methionine; Enkephalins; Molecular Weight; Phosphorylation; Protein Precursors; Protein Processing, Post-Translational; Radioimmunoassay; Tunicamycin | 1992 |
[Peripheral localization of enkephalin-immunoreactive neurons in pteropod molluscs].
Topics: Animals; Central Nervous System; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; Mollusca; Neurons; Tissue Distribution | 1991 |
The phylogeny of Met-enkephalin and Leu-enkephalin: studies on the holostean fish Lepisosteus platyrhincus and the Australian lungfish, Neoceratodus forsteri.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fishes; Male; Molecular Sequence Data; Phylogeny; Protein Precursors; Radioimmunoassay | 1991 |
Cultured astrocytes release proenkephalin.
Topics: Animals; Astrocytes; Cells, Cultured; Chromatography, Gel; Chromatography, High Pressure Liquid; Culture Media; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Protein Precursors; Radioimmunoassay; Rats; RNA, Messenger | 1991 |
Expression of the preproenkephalin A gene in the heart of cardiomyopathic hamsters.
Topics: Aging; Amino Acid Sequence; Animals; Blotting, Northern; Cardiomyopathies; Cricetinae; Enkephalin, Methionine; Enkephalins; Gene Expression; Glyceraldehyde-3-Phosphate Dehydrogenases; Heart Atria; Heart Ventricles; Male; Molecular Sequence Data; Protein Precursors; Radioimmunoassay; RNA, Messenger | 1991 |
Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle, Smooth; Myenteric Plexus; Narcotics; Pertussis Toxin; Pyrrolidines; Sufentanil; Virulence Factors, Bordetella | 1991 |
Quinolinic acid elevates striatal and pallidal Met-enkephalin levels: the role of enkephalin synthesis and release.
Topics: Animals; Blotting, Northern; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Globus Pallidus; Male; Protein Precursors; Quinolinic Acid; Quinolinic Acids; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA Probes; RNA, Messenger; Stereotaxic Techniques | 1991 |
Immunohistochemical localization of DARPP-32 in striatal projection neurons and striatal interneurons: implications for the localization of D1-like dopamine receptors on different types of striatal neurons.
Topics: Animals; Basal Ganglia; Choline O-Acetyltransferase; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; Interneurons; Nerve Tissue Proteins; Neurons; Neuropeptide Y; Phosphoproteins; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Substantia Nigra | 1991 |
Enkephalin lowers vascular resistance in dog hindlimb via a peripheral nonlimb site.
Topics: Animals; Dogs; Enkephalin, Methionine; Enkephalins; Female; Hindlimb; Injections, Intra-Arterial; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Regional Blood Flow; Vascular Resistance | 1991 |
Brain passage of BUBU, a highly selective and potent agonist for delta opioid receptors: in vivo binding and mu versus delta receptors occupancy.
Topics: Analgesics; Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Kinetics; Male; Mice; Motor Activity; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Characterization of delta-sleep-inducing peptide-evoked release of Met-enkephalin from brain synaptosomes in rats.
Topics: Animals; Brain; Calcium; Calcium Radioisotopes; Cerebral Cortex; Delta Sleep-Inducing Peptide; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Male; Mesencephalon; Radioimmunoassay; Rats; Rats, Inbred Strains; Synaptosomes | 1991 |
Comparative incorporation of proenkephalin-derived peptides, chromogranin A, and dopamine beta-hydroxylase into chromaffin vesicles.
Topics: Animals; Cattle; Cells, Cultured; Chromaffin System; Chromogranin A; Chromogranins; Dopamine beta-Hydroxylase; Enkephalin, Methionine; Enkephalins; Methionine; Protein Precursors; Sulfur Radioisotopes | 1991 |
Processing of proenkephalin in adrenal chromaffin cells.
Topics: Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Methionine; Protein Precursors; Sulfur Radioisotopes; Tetrabenazine; Time Factors | 1991 |
GABA and enkephalin in the lateral septum of the guinea pig: light and electron microscopic evidence for interrelations.
Topics: Animals; Antibody Specificity; Brain; Brain Chemistry; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Guinea Pigs; Immunohistochemistry; Male; Microscopy, Electron; Nerve Endings | 1991 |
Chronic treatment with chlorpromazine, thioridazine or haloperidol increases striatal enkephalins and their release from rat brain.
Topics: Animals; Apomorphine; Brain Chemistry; Chlorpromazine; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Haloperidol; Male; Rats; Rats, Inbred Strains; Thioridazine | 1991 |
Differential processing of proenkephalin-A by human peripheral blood monocytes and T lymphocytes.
Topics: Adult; Enkephalin, Methionine; Enkephalins; Gene Expression; Humans; Monocytes; Protein Precursors; RNA, Messenger; T-Lymphocytes | 1991 |
Nicotine-induced alterations in peripheral tissue concentrations of native and cryptic Met- and Leu-enkephalin.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Male; Nicotine; Rats; Rats, Inbred Strains; Viscera | 1991 |
Preproenkephalin mRNA and methionine-enkephalin increase in mouse striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; G(M1) Ganglioside; Immunologic Techniques; Male; Mice; Mice, Inbred Strains; Nomifensine; Protein Precursors; RNA, Messenger; Selegiline | 1991 |
Interaction between enkephalinergic and dopaminergic systems in stressful situations.
Topics: Animals; Apomorphine; Conditioning, Operant; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Hydroxydopamines; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurons; Oxidopamine; Pimozide; Receptors, Dopamine; Stress, Psychological | 1991 |
[Opioid peptides in cerebrospinal fluids of epileptic patients].
Topics: Adolescent; Adult; beta-Endorphin; Child; Enkephalin, Leucine; Enkephalin, Methionine; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Middle Aged | 1991 |
An in vitro study on the hippocampal electrophysiological properties of enkephalinase inhibitors in rats.
Topics: Animals; Dipeptides; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Neprilysin; Perfusion; Rats; Rats, Inbred Strains; Thiorphan | 1991 |
TRH-enkephalin interactions in the amygdaloid complex during gastric stress ulcer formation in rats.
Topics: Amygdala; Animals; Cold Temperature; Drug Interactions; Enkephalin, Methionine; Enkephalins; Gastric Mucosa; Male; Neurons; Peptic Ulcer; Rats; Rats, Inbred Strains; Stress, Physiological; Thyrotropin-Releasing Hormone | 1991 |
Enkephalin-containing nerve cell bodies in the substantia nigra of the rat: demonstration by immunohistochemistry and in situ hybridization.
Topics: Animals; Colchicine; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Immunohistochemistry; Mesencephalon; Neurons; Nucleic Acid Hybridization; Organ Specificity; Oxidopamine; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Substantia Nigra | 1991 |
Evidence for an enkephalinergic system in the nervous system of the pond snail, Lymnaea stagnalis.
Topics: Animals; Cell Membrane; Enkephalin, Leucine; Enkephalin, Methionine; Etorphine; Immune Sera; Immunohistochemistry; Kinetics; Lymnaea; Nervous System; Nervous System Physiological Phenomena; Neuropeptides; Receptors, Opioid | 1990 |
Proenkephalin A and proopiomelanocortin peptides in human cerebrospinal fluid.
Topics: beta-Endorphin; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Humans; Hydrolysis; Mass Spectrometry; Pro-Opiomelanocortin; Protein Precursors; Radioimmunoassay; Radioligand Assay; Receptors, Opioid | 1990 |
Colocalized peptides in gonadotrophs: LeuEnkephalin and ACTH interact differently on GnRH induced LH and FSH release.
Topics: Adrenocorticotropic Hormone; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Male; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Rats, Inbred Strains | 1990 |
Modulation of dopamine-induced hypermotility following injection of various opioids into the nucleus accumbens.
Topics: Animals; Chlorpromazine; Dopamine; Dopamine Antagonists; Enkephalin, Methionine; Enkephalins; Haloperidol; Male; Morphine; Motor Activity; Nucleus Accumbens; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Short- and long-term alterations of gene expression in limbic structures by repeated electroconvulsive-induced seizures.
Topics: Animals; Electroshock; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Limbic System; Male; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Tyrosine 3-Monooxygenase | 1990 |
HPLC-ECD determination of the enzymatic hydrolysis of [leu]- and [met]enkephalin in rat plasma.
Topics: Acetylcholinesterase; Aminopeptidases; Animals; Captopril; CD13 Antigens; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Leucine; Male; Oligopeptides; Rats; Rats, Inbred Strains; Thiorphan; Tyrosine | 1990 |
Hemodynamic responses of conscious rats following intrathecal injections of prodynorphin-derived opioids: independence of action of intrathecal arginine vasopressin.
Topics: Animals; Arginine Vasopressin; beta-Endorphin; Blood Pressure; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Heart Rate; Hemodynamics; Injections, Spinal; Male; Narcotics; Norepinephrine; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains | 1990 |
The occurrence and receptor specificity of endogenous opioid peptides within the pancreas and liver of the rat. Comparison with brain.
Topics: Animals; beta-Endorphin; Brain; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Immunohistochemistry; Liver; Male; Pancreas; Radioimmunoassay; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Medulla Oblongata; Morphine; Neurons; Quinoxalines; Rats | 1990 |
Characterization of the opioid receptor type mediating inhibition of rat gastric somatostatin secretion.
Topics: Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Somatostatin | 1990 |
Prostanoids modulate opioid cerebrovascular responses in newborn pigs.
Topics: Administration, Topical; Animals; Animals, Newborn; Arachnoid; Arterioles; beta-Endorphin; Blood Gas Analysis; Cerebrovascular Circulation; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hydrogen-Ion Concentration; Indomethacin; Male; Pia Mater; Prostaglandins; Swine; Vasodilation | 1990 |
Differentiation of acupuncture and nonacupuncture points by difference of associated opioids in the spinal cord in production of analgesia by acupuncture and nonacupuncture point stimulation, and relations between sodium and those opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acupuncture Analgesia; Acupuncture Points; Analgesics; Animals; Benzomorphans; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride; Spinal Cord | 1990 |
Tissue kallikrein processes small proenkephalin peptides.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Kallikreins; Kinetics; Molecular Sequence Data; Pancreas; Protein Precursors; Swine | 1991 |
Regulation of proenkephalin synthesis in adrenal medullary chromaffin cells.
Topics: Adrenal Medulla; Animals; Cells, Cultured; Chromaffin System; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Methionine; Protein Precursors; Sulfur Radioisotopes | 1991 |
Purification and characterization of a novel thiol protease involved in processing the enkephalin precursor.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Cattle; Chromaffin Granules; Chromatography, Gel; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Enkephalin, Methionine; Enkephalins; Humans; Hydrogen-Ion Concentration; Methionine; Molecular Sequence Data; Pepstatins; Protease Inhibitors; Protein Precursors; Protein Processing, Post-Translational; Rats; Substrate Specificity | 1991 |
Circadian regulation of the biosynthesis of cardiac Met-enkephalin and precursors in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blotting, Northern; Circadian Rhythm; Enkephalin, Methionine; Enkephalins; Hypertension; Male; Myocardium; Protein Precursors; Protein Processing, Post-Translational; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger | 1991 |
Applications of simulated annealing to the multiple-minima problem in small peptides.
Topics: Algorithms; Computer Simulation; Enkephalin, Leucine; Enkephalin, Methionine; Glycine; Hydrogen Bonding; Models, Molecular; Monte Carlo Method; Oligopeptides; Peptides; Protein Conformation; Thermodynamics | 1991 |
Insulin-like growth factor I enhances proenkephalin synthesis and dopamine beta-hydroxylase activity in adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; Dopamine beta-Hydroxylase; Enkephalin, Methionine; Enkephalins; Insulin; Insulin-Like Growth Factor I; Protein Biosynthesis; Protein Precursors; Recombinant Proteins | 1991 |
[The effect of the aminopeptidase inhibitor bestatin on the enkephalin level in the rat brain].
Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Dimethyl Sulfoxide; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Leucine; Male; Rats | 1990 |
Sensitive method for measuring hydrolysis of enkephalins in plasma, using high-performance liquid chromatography with electrochemical detection.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Chickens; Chromatography, High Pressure Liquid; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hydrolysis; Male; Mice; Molecular Sequence Data; Peptide Fragments; Rats; Rats, Inbred Strains | 1990 |
Proenkephalin A-derived peptide E and its fragments alter opioid contractility in the small intestine.
Topics: Animals; Dogs; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Intestine, Small; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptide Fragments; Peptides; Protein Precursors; Vas Deferens | 1990 |
The proenkephalin-A-derivative Met-enkephalin-Arg-Gly-Leu is not present in the feline species.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Cats; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Molecular Sequence Data; Radioimmunoassay | 1990 |
In vitro influence of enkephalins on the proliferative response of mouse and rat splenic lymphocytes to phytohemagglutinin.
Topics: Animals; Cell Division; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred BALB C; Phytohemagglutinins; Rats; Rats, Inbred Strains | 1990 |
[Effects of monoamine oxidase B inhibitor and MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) on enkephalin levels in mice].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Phenethylamines; Radioimmunoassay; Selegiline | 1990 |
Adrenergic regulation of hypothalamic proenkephalin neurons: evidence for opposite effects in subpopulations terminating in median eminence and neurointermediate pituitary.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Hydroxydopamines; Hypothalamus; In Vitro Techniques; Male; Median Eminence; Methoxamine; Neural Pathways; Neurons; Oxidopamine; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Inbred Strains; Reserpine; Sympathetic Nervous System | 1990 |
Responses of morphine dependent opioid neurones to stressors.
Topics: Animals; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Morphine Dependence; Naloxone; Neurons; Pregnancy; Rats; Stress, Physiological; Tissue Distribution | 1990 |
[Opioid peptides in RA: modulation of immunologic mechanisms and mental states].
Topics: Adult; Aged; Arthritis, Rheumatoid; beta-Endorphin; Emotions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Facial Expression; Female; Humans; Immunoglobulins; Leukocyte Count; Lymphocytes; Male; Middle Aged | 1990 |
A study on opioid peptides in CSF of patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; beta-Endorphin; Cerebrospinal Fluid Proteins; Child; Enkephalin, Leucine; Enkephalin, Methionine; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Humans; Male; Middle Aged; Radioimmunoassay; Sex Factors | 1990 |
[Effects of the enkephalins on natural killer cytotoxicity].
Topics: Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Female; Killer Cells, Natural; Male; Mice; Mice, Inbred BALB C | 1990 |
Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amino Acid Sequence; Animals; Diuresis; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Naltrexone; Oligopeptides; Phenazocine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens | 1990 |
Expression of zeta (zeta), a growth-related opioid receptor, in metastatic adenocarcinoma of the human cerebellum.
Topics: Adenocarcinoma; Cerebellar Neoplasms; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Humans; Male; Middle Aged; Receptors, Opioid | 1990 |
Opioid involvement in epileptogenic and neurovisceral activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Digestive System; Enkephalin, Leucine; Enkephalin, Methionine; Epilepsy; Kainic Acid; Male; Mice; Naloxone; Nervous System; Pyrrolidines; Receptors, Opioid | 1990 |
Modulation of superoxide anion release from human polymorphonuclear cells by Met- and Leu-enkephalin.
Topics: Anions; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
[Experimental research on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian animal models in the rhesus monkey and C57 black mouse].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain Chemistry; Disease Models, Animal; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Parkinson Disease, Secondary; Substantia Nigra | 1990 |
Antioxidative properties of Met- and Leu-enkephalin.
Topics: Antioxidants; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Neutrophils; Superoxide Dismutase; Superoxides | 1990 |
Neuroendocrine control of thymic hormonal production. II. Stimulatory effects of endogenous opioids on thymulin production by cultured human and murine thymic epithelial cells.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epithelium; Fluorescent Antibody Technique; Humans; Mice; Mice, Inbred C57BL; Naloxone; Rats; Thymic Factor, Circulating; Thymus Gland; Thymus Hormones | 1990 |
Origin of some enkephalin-containing afferents to the ventro-medial region of the globus pallidus in the rat.
Topics: Amygdala; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Globus Pallidus; Immunoenzyme Techniques; Immunohistochemistry; Neurons, Afferent; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Substantia Innominata; Wheat Germ Agglutinins | 1990 |
Association of proenkephalin transcripts with polyribosomes in the heart.
Topics: Animals; Animals, Newborn; Cells, Cultured; Centrifugation, Density Gradient; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Male; Myocardium; Nucleic Acid Hybridization; Polyribosomes; Protein Biosynthesis; Protein Precursors; Rats; Rats, Inbred Strains; Ribonucleases; RNA, Messenger; Transcription, Genetic | 1990 |
Differential association of endogenous proenkephalin-derived peptides with membranes of microsomes from rat striatum, adrenal medulla and heart ventricle.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Heart Ventricles; Intracellular Membranes; Microsomes; Molecular Sequence Data; Organ Specificity; Protein Precursors; Protein Processing, Post-Translational; Rats; Sequence Homology, Nucleic Acid; Species Specificity; Vertebrates; Xenopus | 1990 |
The distribution of enkephalins in human carotid bodies showing cellular proliferation and chronic glomitis.
Topics: Aged; Aged, 80 and over; Biomarkers; Carotid Body; Cell Count; Cell Division; Chronic Disease; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; Hyperplasia; Immunoenzyme Techniques; Inflammation; Male; Middle Aged | 1990 |
[Effects of enkephalins on associative processes of parietal cortex neurons].
Topics: Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Iontophoresis; Neurons; Parietal Lobe | 1990 |
The modulating influence of enkephalins on the bone marrow haemopoiesis in stress.
Topics: Animals; Bone Marrow; Cell Count; Cell Differentiation; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hematopoiesis; Male; Mice; Naloxone; Phenylalanine; Restraint, Physical; Stress, Physiological; Time Factors | 1990 |
In vivo modulation of the immune system by enkephalins.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Methionine; Graft Rejection; Hypersensitivity, Delayed; Immune System; Injections, Intraperitoneal; Injections, Intraventricular; Rats; Rats, Inbred Lew; Rats, Inbred Strains | 1990 |
Haloperidol-induced increase in striatal concentration of the tripeptide, Tyr-Gly-Gly, provides an index of increased enkephalin release in vivo.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Haloperidol; Immune Sera; Male; Neprilysin; Oligopeptides; Osmolar Concentration; Radioimmunoassay; Rats; Rats, Inbred Strains; Thiorphan; Time Factors; Tissue Distribution | 1990 |
Neurohormones regulate T cell function.
Topics: Amino Acid Sequence; Chemotaxis, Leukocyte; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Structure-Activity Relationship; T-Lymphocytes | 1990 |
Detection of Met-enkephalin and Leu-enkephalin in the brain of the hagfish, Eptatretus stouti, and the lamprey, Petromyzon marinus.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fishes; Hagfishes; Lampreys; Male; Molecular Sequence Data; Protein Precursors; Radioimmunoassay | 1990 |
In vitro interactions of opioid peptides with phospholipids. IV. Methionine enkephalin versus leucine enkephalin.
Topics: Circular Dichroism; Enkephalin, Leucine; Enkephalin, Methionine; Molecular Conformation; Phosphatidylcholines; Phosphatidylserines; Spectrophotometry, Ultraviolet | 1990 |
The molecular weight profile of enkephalin-containing peptides in the sheep adrenal gland changes during development.
Topics: Adrenal Glands; Animals; Enkephalin, Methionine; Enkephalins; Gestational Age; Molecular Weight; Protein Processing, Post-Translational; Sheep | 1990 |
Attenuation of reflex pressor and ventilatory responses to static muscular contraction by intrathecal opioids.
Topics: Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Heart Rate; Injections, Spinal; Muscle Contraction; Respiration; Sciatic Nerve | 1990 |
Secondary structure characteristics of proenkephalin peptides E, B, and F.
Topics: Adrenal Medulla; Circular Dichroism; Enkephalin, Methionine; Enkephalins; Fourier Analysis; Humans; Peptides; Protein Conformation; Protein Precursors; Solutions; Spectrophotometry, Infrared; Structure-Activity Relationship | 1990 |
Dot immunobinding and immunoblotting of picogram and nanogram quantities of small peptides on activated nitrocellulose.
Topics: Angiotensin I; Angiotensin II; Animals; Chromatography, Thin Layer; Collodion; Enkephalin, Leucine; Enkephalin, Methionine; HIV; Humans; Immunoblotting; Peptides; Rabbits | 1990 |
[The role of humoral factors in the mechanism of the analgesic effect of electroacupuncture].
Topics: Animals; Dinoprost; Dogs; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Histamine; Pain; Serotonin | 1990 |
Enkephalins in pheochromocytoma: studies in a rat model.
Topics: Adrenal Gland Neoplasms; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; Epitopes; Heart Rate; Humans; Norepinephrine; Pheochromocytoma; Radioimmunoassay; Rats | 1985 |
Peptide-containing nerve fibers in the stomach wall of rat and mouse.
Topics: Animals; Denervation; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fluorescent Antibody Technique; Gastrin-Releasing Peptide; Male; Mice; Muscle, Smooth; Nerve Tissue Proteins; Neurons; Neuropeptide Y; Peptides; Rats; Rats, Inbred Strains; Stomach; Substance P; Vasoactive Intestinal Peptide | 1985 |
Localization of substance P-like, leucine-enkephalin-like, methionine-enkephalin-like, and FMRFamide-like immunoreactivity in the eyestalk of the fiddler crab, Uca pugilator.
Topics: Animals; Brachyura; Enkephalin, Leucine; Enkephalin, Methionine; Eye; FMRFamide; Oligopeptides; Substance P | 1985 |
Presence and ontogeny of enkephalin and substance P in the chick ciliary ganglion.
Topics: Animals; Chick Embryo; Chickens; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; Radioimmunoassay; Substance P | 1985 |
Opioid inhibition of synaptic transmission in the guinea-pig myenteric plexus.
Topics: Acetylcholine; Action Potentials; Animals; Barium; Electric Conductivity; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Guinea Pigs; Ileum; Morphine; Myenteric Plexus; Naloxone; Nicotine; Potassium; Substance P; Synaptic Transmission | 1985 |
[Effect of opioid peptides on nervous tissue in vitro].
Topics: Animals; Animals, Newborn; beta-Endorphin; Culture Techniques; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Endorphin; Ganglia, Spinal; Ganglia, Sympathetic; Organ Specificity; Rats; Rats, Inbred Strains | 1985 |
Coexistence of peptide immunoreactivity in sensory neurons of the cat.
Topics: Animals; Bombesin; Cats; Cholecystokinin; Enkephalin, Leucine; Enkephalin, Methionine; Female; Ganglia, Spinal; Immunoenzyme Techniques; Male; Neurotensin; Peptides; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1985 |
[Immunocytochemical study of the spinal distribution of substance P, enkephalins, cholecystokinin and serotonin in amyotrophic lateral sclerosis].
Topics: Amyotrophic Lateral Sclerosis; Cholecystokinin; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neurotransmitter Agents; Serotonin; Spinal Cord; Substance P | 1985 |
Enkephalins increase cyclic adenosine monophosphate content, calcium uptake, and contractile state in cultured chick embryo heart cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Chick Embryo; Cyclic AMP; Enkephalin, Methionine; Enkephalins; GTP-Binding Proteins; Heart; Myocardial Contraction; Myocardium; Naloxone | 1986 |
The glutamate decarboxylase-, leucine enkephalin-, methionine enkephalin- and substance P-immunoreactive neurons in the neostriatum of the rat and cat: evidence for partial population overlap.
Topics: Animals; Antigen-Antibody Reactions; Brain Mapping; Cats; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Fixatives; Glutamate Decarboxylase; Neurons; Rats; Rats, Inbred Strains; Species Specificity; Staining and Labeling; Substance P | 1986 |
Stabilization of methionine-enkephalin in human and rat blood.
Topics: Animals; Aprotinin; Blood Specimen Collection; Chromatography, Gel; Chromatography, Thin Layer; Citrates; Citric Acid; Enkephalin, Methionine; Enkephalins; Humans; Male; Rats; Rats, Inbred Strains; Temperature | 1986 |
Cytoarchitecture, fiber connections, and some histochemical aspects of the interpeduncular nucleus in the rat.
Topics: Acetylcholinesterase; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Female; Immunoenzyme Techniques; Limbic System; Mesencephalon; Neural Pathways; Rats; Serotonin; Substance P | 1986 |
Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin.
Topics: Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Frontal Lobe; Male; Neurokinin A; Neuropeptides; Rats; Rats, Inbred Strains; Stress, Psychological; Substance P; Tegmentum Mesencephali | 1986 |
Lack of change in basal ganglia neuropeptide content following subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of the common marmoset.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Basal Ganglia; Behavior, Animal; Callitrichinae; Caudate Nucleus; Enkephalin, Leucine; Enkephalin, Methionine; Female; Homovanillic Acid; Male; Neuropeptides; Putamen; Pyridines; Sincalide; Substance P | 1986 |
Distribution of some peptides (substance P, [Leu]enkephalin, [Met]enkephalin) in the brain stem and spinal cord of a lizard, Varanus exanthematicus.
Topics: Animals; Brain Mapping; Brain Stem; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; Lizards; Spinal Cord; Substance P | 1986 |
Striato-nigral dynorphin and substance P pathways in the rat. I. Biochemical and immunohistochemical studies.
Topics: Animals; Corpus Striatum; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glutamate Decarboxylase; Male; Motor Activity; Neural Pathways; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1986 |
Enkephalin modulation of neural transmission in the cat stellate ganglion: pharmacological actions of exogenous opiates.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Cats; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Ganglia, Sympathetic; Heart Rate; Histamine; Male; Morphine; Synaptic Transmission | 1986 |
[Distribution of substance P- and enkephalin-immunoreactivity in the intestine of guinea pigs during development].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Intestines; Substance P; Tissue Distribution | 1986 |
An immunohistochemical study of six biologically active peptides in the human brain.
Topics: Aged; Aged, 80 and over; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; Humans; Middle Aged; Neuropeptides; Sincalide; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1986 |
[Establishment of a map of neurons in the brain of Eisenia fetida (Annelida, Oligochaeta) containing substances immunologically specific to vertebrate peptides].
Topics: Animals; Brain; Corticotropin-Releasing Hormone; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Growth Hormone-Releasing Hormone; Histocytochemistry; Immunologic Tests; Neurons; Neuropeptides; Oligochaeta; Serotonin; Sincalide; Substance P | 1987 |
Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Bucladesine; Cell Line; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Humans; Neuroblastoma; Peptide Fragments; Protein Precursors; Reserpine | 1986 |
The effects of endorphins on mucous glycoprotein secretion from feline airways in vitro.
Topics: alpha-Endorphin; Animals; beta-Endorphin; Cats; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Endorphin; Glycoproteins; Morphine; Mucus; Naloxone; Organ Culture Techniques; Secretory Rate; Trachea | 1987 |
Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.
Topics: Animals; beta-Endorphin; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Ion Channels; Locus Coeruleus; Membrane Potentials; Narcotics; Neurons; Potassium; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Brain neuropeptides in progressive supranuclear palsy.
Topics: Aged; Brain; Cholecystokinin; Corpus Striatum; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Neuropeptides; Substance P; Substantia Nigra; Supranuclear Palsy, Progressive | 1987 |
Differential effects of acute and chronic administration of haloperidol on substance P and enkephalins in diverse rat brain areas.
Topics: Amygdala; Animals; Brain Chemistry; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Haloperidol; Hypothalamus; Limbic System; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Time Factors | 1986 |
Mu-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways.
Topics: Animals; Autonomic Nervous System; Bronchi; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Morphine; Muscle Contraction; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Substance P; Trachea | 1987 |
[Pressor effects of intracerebroventricularly administered substance P are mediated by enkephalins and beta-endorphin in rats].
Topics: Animals; beta-Endorphin; Blood Pressure; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Rats; Substance P | 1987 |
Effect of BW 942C, an enkephalinlike pentapeptide, on sodium and chloride transport in the rabbit ileum.
Topics: Animals; Antidiarrheals; Biological Transport, Active; Chlorides; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Ileum; Intestinal Absorption; Ion Channels; Rabbits; Sodium | 1988 |
Modulation of humoral immune responses by endogenous opioids.
Topics: Anaphylaxis; Animals; Antibody Formation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Histamine Release; Mice; Morphine; Naloxone; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Rats | 1988 |
Inhibition of exocrine pancreatic secretion by opiates is mediated by suppression of cholinergic transmission: characterization of receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Amylases; Animals; Cholinergic Fibers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Narcotics; Pancreas; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptic Transmission | 1988 |
Characterization of content and chromatographic forms of neuropeptides in purified nerve varicosities prepared from guinea pig myenteric plexus.
Topics: Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Galanin; Gastrin-Releasing Peptide; Gastrointestinal Hormones; Guinea Pigs; Ileum; Myenteric Plexus; Neuropeptides; Peptides; Substance P; Vasoactive Intestinal Peptide | 1988 |
Isolation of endopeptidase-24.11 (EC 3.4.24.11, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin.
Topics: Animals; Bombesin; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Gastric Mucosa; Metalloendopeptidases; Neprilysin; Peptide Fragments; Peptide Mapping; Substance P | 1988 |
Voltage-regulated calcium channels involved in the regulation of enkephalin synthesis are blocked by phorbol ester treatment.
Topics: Animals; Calcium; Cattle; Enkephalin, Methionine; Enkephalins; Ion Channels; Lanthanum; Nicotinic Acids; Oxadiazoles; Potassium Chloride; RNA, Messenger; Tetradecanoylphorbol Acetate | 1988 |
Prodynorphin gene expression in spinal cord is enhanced after traumatic injury in the rat.
Topics: Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Male; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA; RNA, Complementary; RNA, Messenger; Spinal Cord Injuries | 1988 |
Chronic chlorimipramine does not reverse the reduction of cerebrospinal fluid Met-enkephalin-like immunoreactivity in chronic-pain patients.
Topics: Adult; Aged; Chronic Disease; Clomipramine; Enkephalin, Methionine; Enkephalins; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Pain; Radioimmunoassay; Serotonin | 1987 |
Levels of Met-enkephalin, Leu-enkephalin, substance P and cholecystokinin in the brain of the common marmoset following long term 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Callitrichinae; Cholecystokinin; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Female; Homovanillic Acid; Male; Organ Specificity; Pyridines; Reference Values; Substance P | 1988 |
Neurotensin, substance P, neurokinin-alpha, and enkephalin: injection into ventral tegmental area in the rat produces differential effects on operant responding.
Topics: Animals; Conditioning, Operant; Dextroamphetamine; Enkephalin, Methionine; Enkephalins; Injections; Male; Neurokinin A; Neurotensin; Rats; Rats, Inbred Strains; Reinforcement Schedule; Substance P; Tegmentum Mesencephali | 1989 |
Neuropeptides in the human appendix. Distribution and motor effects.
Topics: Appendix; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Enkephalins; Galanin; Gastrin-Releasing Peptide; Humans; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons; Neuropeptide Y; Neuropeptides; Peptide PHI; Peptides; Protein Precursors; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1989 |
Elucidation of some fragmentations of small peptides using sequential mass spectrometry on a hybrid instrument.
Topics: Angiotensin II; Angiotensin III; Enkephalin, Leucine; Enkephalin, Methionine; Mass Spectrometry; Peptide Fragments | 1989 |
Decrease in a proenkephalin peptide in cerebrospinal fluid in Huntington's disease and progressive supranuclear palsy.
Topics: Adult; Aged; Aged, 80 and over; Enkephalin, Methionine; Enkephalins; Humans; Huntington Disease; Middle Aged; Protein Precursors; Supranuclear Palsy, Progressive | 1989 |
[Function of the endogenous opioid system in hypoxic hypoxia].
Topics: Adrenal Glands; Animals; beta-Endorphin; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hypoxia; Lactates; Male; Mice; Rats; Rats, Inbred Strains | 1989 |
Immunoreactive beta-endorphin and met- and leu-enkephalin contents in pancreas and pituitary of corpulent (cp/cp) rats.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Male; Obesity; Pancreas; Pituitary Gland; Rats; Rats, Inbred SHR | 1989 |
[Plasma levels of endogenous opioid peptides in patients with chronic colitis].
Topics: Adult; beta-Endorphin; Chronic Disease; Colitis; Colitis, Ulcerative; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Middle Aged | 1989 |
Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats.
Topics: Animals; beta-Endorphin; Corpus Striatum; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Morphine; Naltrexone; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Substance Withdrawal Syndrome | 1989 |
Purification and assay of opioid activity of low molecular weight enkephalin-immunoreactive peptides generated by peptic digestion of rat plasma proteins.
Topics: Amino Acids; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Oligopeptides; Pepsin A; Radioligand Assay; Rats; Receptors, Opioid | 1989 |
Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antidiarrheals; Constipation; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Differential down-regulation of delta opioid binding sites during physical dependence on methionine enkephalin in the rat.
Topics: Animals; Brain; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Substance-Related Disorders | 1989 |
Inhibition of adrenergic transmission by methionine- and leucine-enkephalins is impaired in the mesenteric vasculatures of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Hypertension; Male; Mesenteric Arteries; Naloxone; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Sympathetic Nervous System; Synaptic Transmission | 1989 |
Stimulatory effects of opioid neuropeptides on locomotory activity and conformational changes in invertebrate and human immunocytes: evidence for a subtype of delta receptor.
Topics: Animals; Bivalvia; Cell Movement; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Insecta; Lymphocytes; Receptors, Opioid; Receptors, Opioid, delta; Species Specificity; Structure-Activity Relationship | 1989 |
Effects of opioid agonists on sympathetic and parasympathetic transmission to the dog heart.
Topics: Animals; Blood Pressure; Dogs; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Heart Rate; Morphine; Pentazocine; Receptors, Opioid; Sympathetic Nervous System; Synaptic Transmission; Vagus Nerve | 1989 |
Antitumor activity of enkephalin analogues in inhibiting PYB6 tumor growth in mice and immunological effects of methionine enkephalinamide.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antineoplastic Agents; Enkephalin, Methionine; Enkephalins; Female; Fibrosarcoma; Killer Cells, Natural; Lymphocyte Activation; Mice; Naloxone; Receptors, Opioid; Tumor Cells, Cultured | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Biologically active conformation of [Met5]- and [Leu5]enkephalin on delta opioid receptor.
Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Models, Molecular; Molecular Sequence Data; Muscle, Smooth; Phenylalanine; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Naloxone-insensitive inhibitory and excitatory effects of opioid agonists in the rat isolated uterus.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Estrus; Female; In Vitro Techniques; Morphine; Naloxone; Narcotics; Potassium Chloride; Rats; Rats, Inbred Strains; Uterine Contraction; Uterus | 1989 |
Brain region and gene specificity of neuropeptide gene expression in cultured astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Neuropeptides; Protein Precursors; Radioimmunoassay; Rats; RNA, Messenger; Somatostatin | 1989 |
Presynaptic auto- and allelo-receptor regulation of hypothalamic opioid peptide release.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Narcotic Antagonists; Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
[An experimental study on the contents of enkephalins in the cerebrospinal fluid in rabbits with unilateral destructive lesions produced in the substantia nigra and their relation to the regulation of MIF-1].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; MSH Release-Inhibiting Hormone; Parkinson Disease, Secondary; Rabbits; Substantia Nigra | 1989 |
Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla.
Topics: Action Potentials; Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Male; Medulla Oblongata; Peptide Fragments; Periaqueductal Gray; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.
Topics: Action Potentials; Animals; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Myenteric Plexus; Naloxone; Sufentanil | 1989 |
The ultrastructural localization of enkephalin and substance P immunoreactivities in the nucleus tractus solitarii of the cat.
Topics: Animals; Cats; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Medulla Oblongata; Microscopy, Electron; Substance P; Synaptic Vesicles | 1985 |
Effects of chlordecone administration on brain and pituitary peptide systems.
Topics: Aging; Animals; Animals, Newborn; beta-Endorphin; Brain; Castration; Chlordecone; Diet; Diethylstilbestrol; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Estrogens; Female; Insecticides; Luteinizing Hormone; Male; Nerve Tissue Proteins; Pituitary Gland, Anterior; Prolactin; Rats; Time Factors | 1985 |
Substance P, enkephalins, somatostatin, cholecystokinin, oxytocin, and vasopressin in human spinal cord.
Topics: Adult; Aged; Cholecystokinin; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fetus; Humans; Male; Middle Aged; Oxytocin; Radioimmunoassay; Spinal Cord; Substance P; Tissue Distribution; Vasopressins | 1985 |
Proenkephalin A is expressed in mesodermal lineages during organogenesis.
Topics: Animals; Blotting, Northern; Cell Differentiation; Enkephalin, Methionine; Enkephalins; Gestational Age; Histocytochemistry; Kidney; Mesoderm; Mice; Mice, Inbred BALB C; Morphogenesis; Protein Precursors; Radioimmunoassay; Rats; RNA, Messenger | 1989 |
Measurement of methionine enkephalin and leucine enkephalin in rat brain regions by high-performance liquid chromatography with coulometric electrochemical detection.
Topics: Animals; Brain Chemistry; Cerebellum; Chromatography, High Pressure Liquid; Corpus Striatum; Electrochemistry; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Male; Rats; Rats, Inbred Strains | 1989 |
Multi-dimensional high-performance liquid chromatography of opioid peptides following pre-column derivatization with naphthalene-2,3-dicarboxaldehyde in the presence of cyanide ion. Preliminary results on the determination of leucine- and methionine-enkep
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Cyanides; Enkephalin, Leucine; Enkephalin, Methionine; Indicators and Reagents; Kinetics; Male; Naphthalenes; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature | 1989 |
Mitogenic activation of the human lymphocytes induce the release of proenkephalin derived peptides.
Topics: Adult; Cells, Cultured; Chromatography, Gel; Enkephalin, Methionine; Enkephalins; Humans; Kinetics; Lymphocyte Activation; Lymphocytes; Molecular Weight; Phytohemagglutinins; Protein Precursors | 1989 |
Determination of leucine enkephalin and methionine enkephalin in equine cerebrospinal fluid by microbore high-performance liquid chromatography and capillary zone electrophoresis coupled to tandem mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Electrophoresis; Enkephalin, Leucine; Enkephalin, Methionine; Horses; Mass Spectrometry | 1989 |
Effects of phentolamine and propranolol on the changes of pain threshold and contents of MEK and LEK in rat brain after EA.
Topics: Animals; Brain; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Male; Pain; Phentolamine; Propranolol; Rats; Sensory Thresholds | 1989 |
Relation of enkephalin-like immunoreactive neurons to other neuropeptide and monoamine-containing neurons in the ventrolateral medulla.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Methionine; Male; Medulla Oblongata; Neurons | 1989 |
[Clinical significance of serum enkephalin analysis in pituitary function tests].
Topics: Cushing Syndrome; Enkephalin, Leucine; Enkephalin, Methionine; Female; Heroin Dependence; Humans; Hypopituitarism; Infant, Newborn; Male; Menstrual Cycle; Nelson Syndrome; Pituitary Function Tests; Pregnancy; Radioimmunoassay; Radioligand Assay; Reference Values | 1989 |
Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo.
Topics: Animals; Brain; Enkephalin, Methionine; Enkephalins; Male; Radioimmunoassay; Rats; Rats, Inbred Strains | 1989 |
Met5-enkephalin- and Met5-enkephalin-Arg6-Gly7-Leu8-immunoreactive nerve fibers in the pig female reproductive system.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Fallopian Tubes; Female; Fluorescent Antibody Technique; Genitalia, Female; Guinea Pigs; Nerve Fibers; Ovary; Protein Precursors; Rats; Swine; Uterus | 1989 |
Nerve fibers showing immunoreactivities for proenkephalin A-derived peptides in the lacrimal glands of the guinea pig.
Topics: Animals; Denervation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fluorescent Antibody Technique; Guinea Pigs; Lacrimal Apparatus; Male; Microscopy, Fluorescence; Nerve Fibers; Perfusion; Protein Precursors | 1989 |
Use of methionine-enkephalin sulfoxide and leucine-enkephalin radio-immunoassays for the measurement of enkephalins in the rat brain.
Topics: Animals; Brain Chemistry; Cross Reactions; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Methionine; Radioimmunoassay; Rats | 1989 |
Regional brain IR-Met-, IR-Leu-enkephalin concentrations during progress and full electrical amygdaloid kindling.
Topics: Amygdala; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Kindling, Neurologic; Male; Radioimmunoassay; Rats; Rats, Inbred Strains | 1989 |
Regional distribution of opioidergic nerves in human and canine prostates.
Topics: Adolescent; Adult; Aged; Animals; Child, Preschool; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Immunohistochemistry; Infant; Male; Middle Aged; Peptide Fragments; Prostate | 1989 |
Effects of enkephalins and the analogue FK-33824 on mean arterial pressure and heart rate in conscious sheep.
Topics: Animals; Blood Pressure; Consciousness; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Female; Heart Rate; Injections, Intraventricular; Naloxone; Sheep | 1989 |
Enkephalin-like immunoreactivity in the cat superior colliculus: distribution, ultrastructure, and colocalization with GABA.
Topics: Animals; Antibodies; Cats; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Microscopy, Electron; Neurons; Superior Colliculi | 1989 |
Effect of electroacupuncture on brain enkephalins content at different times in rats.
Topics: Acupuncture Therapy; Animals; Brain; Circadian Rhythm; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Male; Rats; Time Factors | 1989 |
Immunohistochemical demonstration of enkephalin-containing nerve fibers in guinea pig and rat lungs.
Topics: Animals; Bronchial Arteries; Cricetinae; Enkephalin, Leucine; Enkephalin, Methionine; Female; Lung; Male; Muscle, Smooth; Nerve Fibers; Rats; Rats, Inbred Strains; Trachea | 1989 |
Proenkephalin opioid peptide product in the sensory ganglia of the rat: a developmental immunohistochemical study.
Topics: Aging; Animals; Cell Count; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Gestational Age; Immunohistochemistry; Neurons, Afferent; Protein Precursors; Rats; Trigeminal Nerve | 1989 |
[Content, location and action site of enkephalins in arterial walls].
Topics: Animals; Arteries; Enkephalin, Leucine; Enkephalin, Methionine; Female; Kidney; Male; Mesenteric Arteries; Rabbits | 1989 |
Developmental expression of proenkephalin mRNA and peptides in rat striatum.
Topics: Animals; Animals, Newborn; Brain; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Immunohistochemistry; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1989 |
Met- and leu-enkephalins inhibit rat cortical neurons intracellularly recorded in vivo while morphine excites them: evidence for naloxone-sensitive and naloxone-insensitive effects.
Topics: Animals; Cerebral Cortex; Electrodes; Enkephalin, Leucine; Enkephalin, Methionine; Male; Membrane Potentials; Morphine; Naloxone; Neurons; Rats; Rats, Inbred Strains | 1989 |
Simultaneous extraction of beta-endorphin and leu- and met-enkephalins from human and rat plasma.
Topics: Animals; Chromatography, Ion Exchange; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hydrogen-Ion Concentration; Radioimmunoassay; Rats; Solvents | 1989 |
Enkephalins, their constituents and voluntary drinking of ethanol by the rat.
Topics: Alcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Amino Acids; Animals; Choice Behavior; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Liver; Male; Oligopeptides; Rats; Rats, Inbred Strains | 1989 |
Estimation of relative importance of three enzymes in the inactivation of [Met5]-enkephalin and [Met5]-enkephalin-Arg6 in three isolated preparations by employing the inhibitor specific for each enzyme.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Methionine; Enkephalins; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Male; Metalloendopeptidases; Mice; Mice, Inbred ICR; Neprilysin; Oligopeptides; Peptides; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Strains; Vas Deferens | 1987 |
Antiaversive properties of opioids in the conditioned taste aversion test in the rat.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fentanyl; Male; Methadone; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Taste | 1987 |
[Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon.
Topics: Animals; Cats; Colon; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1987 |
Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells.
Topics: Adenylyl Cyclase Inhibitors; Alprostadil; Cell Division; Cell Membrane; Cyclic AMP; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Fatty Acids, Unsaturated; Fluorescence Polarization; Kinetics; Linoleic Acid; Linoleic Acids; Naloxone; Neuroblastoma; Receptors, Opioid; Tumor Cells, Cultured | 1987 |
Binding of naloxone to human T lymphocytes.
Topics: beta-Endorphin; Binding, Competitive; Blood Platelets; Culture Media; Enkephalin, Leucine; Enkephalin, Methionine; Glutathione; Humans; Kinetics; Morphine; Naloxone; Receptors, Opioid; Sonication; T-Lymphocytes | 1987 |
The mu-opioid receptor in the 7315c tumor cell.
Topics: Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1987 |
Opiate-inhibited adenylate cyclase in rat brain membranes depleted of Gs-stimulated adenylate cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Membrane; Cholera Toxin; Colforsin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; Male; Naloxone; Oligopeptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Fluoride; Virulence Factors, Bordetella | 1988 |
Experimental attempt to simulate receptor site environment. A 500-MHz 1H nuclear magnetic resonance study of enkephalin amides.
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hydrogen; Magnetic Resonance Spectroscopy; Models, Biological; Models, Molecular; Protein Conformation; Receptors, Opioid; Structure-Activity Relationship | 1987 |
[3H][D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6(O-tert-butyl). Two new enkephalin analogs with both a good selectivity and a high affinity toward delta-opioid binding sites.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Kinetics; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Effects of the opioid peptides [Met5]enkephalin-Arg6-Phe7 and [Met5]enkephalin-Arg6-Gly7-Leu8 on cholinergic neurotransmission in the rabbit isolated atria.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Female; Heart; Heart Rate; In Vitro Techniques; Male; Naloxone; Parasympathetic Nervous System; Propranolol; Rabbits; Synaptic Transmission | 1987 |
Opiate mechanisms in the central amygdala and gastric stress pathology in rats.
Topics: Amygdala; Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Microinjections; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Restraint, Physical; Stomach Ulcer; Stress, Physiological | 1988 |
[Specific binding of mu- and delta-ligands by opiate receptors in the rat brain in the presence of reaferon].
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; In Vitro Techniques; Interferon alpha-2; Interferon Type I; Interferon-alpha; Ligands; Male; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Proteins | 1988 |
Endogenous opioids and the growth regulation of a neural tumor.
Topics: Animals; Antineoplastic Agents; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Naloxone; Neoplasm Transplantation; Neuroblastoma; Receptors, Opioid | 1988 |
Naloxone-reversible inhibition by opiates of phagocytosis in Tetrahymena thermophila and mouse macrophages.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Macrophages; Mice; Morphine; Naloxone; Narcotics; Pinocytosis; Receptors, Opioid; Tetrahymena | 1988 |
Effects of enkephalin on lactating rat mammary gland: in vitro studies.
Topics: Animals; Binding Sites; Corpus Striatum; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Lactation; Mammary Glands, Animal; Milk; Pregnancy; Rats; Rats, Inbred Strains | 1988 |
Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.
Topics: Bucladesine; Cell Differentiation; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; GTP-Binding Proteins; Hybrid Cells; Neuroblastoma; Time Factors | 1988 |
Monoclonal antibody to enkephalins with binding characteristics similar to opiate receptor.
Topics: alpha-Endorphin; Animals; Antibodies, Monoclonal; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Mice; Morphine; Naloxone; Receptors, Opioid | 1985 |
Methionine and leucine enkephalin in rat neurohypophysis: different responses to osmotic stimuli and T2 toxin.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Osmosis; Oxytocin; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Sesquiterpenes; T-2 Toxin; Vasopressins; Water Deprivation | 1985 |
Possible interactions between dynorphin and dopaminergic systems in rat basal ganglia and substantia nigra.
Topics: Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Globus Pallidus; Haloperidol; Male; Putamen; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Proenkephalin and prodynorphin related neuropeptides in the cochlea.
Topics: Animals; Cochlea; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Guinea Pigs; Hair Cells, Auditory; Nerve Tissue Proteins; Protein Precursors | 1985 |
Opiate receptor-mediated chemotaxis of human monocytes.
Topics: beta-Endorphin; Chemotaxis; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Humans; In Vitro Techniques; Monocytes; Peptide Fragments; Receptors, Opioid | 1985 |
Localization and quantitation of proenkephalin-derived neuropeptides in the rat hippocampus.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hippocampus; Limbic System; Male; Neural Pathways; Radioimmunoassay; Rats; Rats, Inbred Strains | 1985 |
Separate populations of opioid containing neurons in the guinea-pig intestine.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fluorescent Antibody Technique; Guinea Pigs; Male; Myenteric Plexus; Peptide Fragments; Submucous Plexus; Vasoactive Intestinal Peptide | 1985 |
On the origin of Leu-enkephalin and Met-enkephalin in the rat neurohypophysis.
Topics: Animals; Arginine Vasopressin; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus, Middle; Male; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Sodium Glutamate | 1985 |
Dynorphin levels in parkinsonian patients: Leu5-enkephalin production from either proenkephalin A or prodynorphin in human brain.
Topics: Aged; Brain; Brain Chemistry; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Parkinson Disease; Protein Precursors | 1985 |
Release of immunoreactive Met-enkephalin from the spinal cord by intraventricular beta-endorphin but not morphine in anesthetized rats.
Topics: Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Peptide Fragments; Rats; Rats, Inbred Strains; Spinal Cord | 1985 |
Selective presence of opiate receptors on intestinal circular muscle cells.
Topics: Acetylcholine; Animals; Atropine; Benzomorphans; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Humans; Jejunum; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Proglumide; Receptors, Opioid; Sincalide | 1985 |
Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. I. Behavioral characterization.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Administration Schedule; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Microinjections; Motor Activity; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Tegmentum Mesencephali | 1985 |
Effects of opioid peptides containing the sequence of Met5-enkephalin or Leu5-enkephalin on nicotine-induced secretion from bovine adrenal chromaffin cells.
Topics: Adenosine Triphosphate; Adrenal Medulla; Amino Acid Sequence; Animals; Bacitracin; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guinea Pigs; Leucine; Nicotine; Norepinephrine; Peptide Fragments; Phenanthrolines; Rabbits; Receptors, Opioid; Thiorphan; Tiopronin | 1986 |
Peptidergic efferents from the intercalated nuclei of the amygdala to the parabrachial nucleus in the rat.
Topics: Amygdala; Animals; Corticotropin-Releasing Hormone; Efferent Pathways; Enkephalin, Methionine; Enkephalins; Male; Neurotensin; Neurotransmitter Agents; Peptides; Pons; Protein Precursors; Rats; Somatostatin; Synaptic Transmission | 1985 |
Opioid binding in a rat neurohypophysial fraction enriched in oxytocin and vasopressin nerve endings.
Topics: Animals; Arginine Vasopressin; Binding Sites; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats | 1985 |
In-vitro study of the enkephalinergic hypothesis for non-adrenergic, non-cholinergic innervation in the cat stomach.
Topics: Animals; Atropine; Cats; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; In Vitro Techniques; Male; Morphine; Naloxone; Neurotransmitter Agents; Serotonin; Stomach; Synaptic Transmission | 1986 |
Enkephalin-containing polypeptides in human cerebrospinal fluid.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Hydrogen-Ion Concentration; Molecular Weight; Peptides; Protein Precursors; Radioimmunoassay | 1986 |
Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit.
Topics: Animals; Benzomorphans; Clonidine; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hippocampus; Morphine; Norepinephrine; Rabbits; Receptors, Opioid | 1986 |
Enkephalin but not morphine modulates the motor activity in the frog spinal cord in vitro.
Topics: Animals; Dynorphins; Electric Stimulation; Electrophysiology; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Histocytochemistry; In Vitro Techniques; Morphine; Motor Activity; Naloxone; Rana catesbeiana; Reflex; Spinal Cord | 1986 |
RIA/chromatographic evidence for novel opioid peptide(s) in Squilla mantis ganglia.
Topics: Animals; beta-Endorphin; Brain; Chromatography, Gel; Decapoda; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia; Molecular Weight; Radioimmunoassay; Radioligand Assay; Rats; Receptors, Opioid | 1986 |
Opioids increase potassium conductance in submucous neurones of guinea-pig caecum by activating delta-receptors.
Topics: Adrenergic alpha-Agonists; Animals; Cecum; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth; Neural Conduction; Neurons; Norepinephrine; Potassium; Receptors, Opioid; Receptors, Opioid, delta; Somatostatin | 1986 |
In vitro effects of endogenous opiate peptides on thyrotropin function: inhibition of thyrotropin-releasing hormone release and absence of effect on thyrotropin release.
Topics: alpha-Endorphin; Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; In Vitro Techniques; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hypercapnia; Hypoxia; Peptide Fragments; Receptors, Opioid | 1986 |
Expression of the enkephalin precursor gene in C6 rat glioma cells: regulation by beta-adrenergic agonists and glucocorticoids.
Topics: Adrenergic beta-Agonists; Animals; Cell Line; Dexamethasone; Drug Synergism; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Glioma; Glucocorticoids; Norepinephrine; Nucleic Acid Hybridization; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic | 1986 |
Kainic acid alters the metabolism of Met5-enkephalin and the level of dynorphin A in the rat hippocampus.
Topics: Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Hippocampus; Histocytochemistry; Immunochemistry; Kainic Acid; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred F344; RNA, Messenger; Seizures | 1986 |
Characterization of opioid peptides in the rat stomach.
Topics: Animals; Chromatography; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Radioimmunoassay; Radioligand Assay; Rats; Rats, Inbred Strains; Stomach; Trypsin | 1986 |
Evidence for the presence of adrenocorticotropic and opiate-like hormones in the brains of two sea snakes, Hydrophis cyanocinctus and Lapemis hardwickii.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; beta-Endorphin; Biological Assay; Brain; Brain Chemistry; Corticosterone; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Lipolysis; Male; Melanocyte-Stimulating Hormones; Snakes; Tissue Extracts | 1986 |
Are opioid peptides co-localized with vasopressin or oxytocin in the neural lobe of the rat?
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Histological Techniques; Neurophysins; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Vasopressins | 1986 |
A behavioral role for enkephalins in regulating locomotor activity in the insect Leucophaea maderae: evidence for high affinity kappa-like opioid binding sites.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Morphine; Motor Activity; Orthoptera; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Amygdaloid kindling increases enkephalin-like immunoreactivity but decreases dynorphin-A-like immunoreactivity in rat hippocampus.
Topics: Amygdala; Animals; Brain Stem; Corpus Striatum; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Frontal Lobe; Hippocampus; Histocytochemistry; Hypothalamus; Kindling, Neurologic; Male; Radioimmunoassay; Rats; Rats, Inbred F344 | 1986 |
Synaptosomal membrane-bound form of endopeptidase-24.15 generates Leu-enkephalin from dynorphin1-8, alpha- and beta-neoendorphin, and Met-enkephalin from Met-enkephalin-Arg6-Gly7-Leu8.
Topics: Animals; beta-Endorphin; Brain; Chromatography, High Pressure Liquid; Dynorphins; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Metalloendopeptidases; Peptide Fragments; Protease Inhibitors; Protein Precursors; Rats; Rats, Inbred Strains; Synaptic Membranes; Synaptosomes; Trypsin | 1987 |
Binding characteristics of [3H]opioid ligands to active opioid binding sites solubilized from rat brain membranes by glycodeoxycholate and NaCl: the recovery of binding activity by dilution.
Topics: Animals; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Glycodeoxycholic Acid; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride; Solutions | 1987 |
Brain endo-oligopeptidase A, a putative enkephalin converting enzyme.
Topics: Animals; Bradykinin; Brain; Cattle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Metalloendopeptidases; Neurotensin; Peptide Fragments; Rats; Substrate Specificity; Sulfhydryl Reagents | 1987 |
Activation of periaqueductal grey pools of beta-endorphin by analgetic electrical stimulation in freely moving rats.
Topics: Animals; beta-Endorphin; Dynorphins; Electric Stimulation Therapy; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Locomotion; Male; Periaqueductal Gray; Prolactin; Rats; Rats, Inbred Strains; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1987 |
In vitro studies of the effects of naloxone on the root potentials in the frog spinal cord: enkephalin-like effect on the recurrent presynaptic inhibition.
Topics: Animals; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Membrane Potentials; Naloxone; Rana catesbeiana; Receptors, Opioid; Reflex; Spinal Cord; Synapses; Synaptic Membranes | 1987 |
A re-examination of the localization of immunoreactive dynorphin(1-8), [Leu]enkephalin and [Met]enkephalin in the rat neurohypophysis.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Histocytochemistry; Immunoenzyme Techniques; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats; Rats, Brattleboro; Rats, Inbred Strains | 1987 |
Effect of neuropeptides on macrophage mediated cytotoxicity in normal donors and cancer patients.
Topics: alpha-Endorphin; Breast Neoplasms; Cell Line; Cytotoxicity, Immunologic; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hodgkin Disease; Humans; Macrophages; Naloxone; Neoplasms; Neuropeptides | 1987 |
Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Benzazepines; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Methionine; Enkephalins; Ergolines; Female; Gene Expression Regulation; Hippocampus; Hydroxydopamines; Male; Motor Activity; Neuropeptides; Oxidopamine; Peptide Fragments; Protein Precursors; Quinpirole; Rats; Rats, Inbred Strains; RNA, Messenger; Substantia Nigra; Tachykinins | 1987 |
Calmodulin content in rabbit reticulocyte and the influence of opioid peptides on calmodulin activity in its membrane.
Topics: Animals; beta-Endorphin; Calmodulin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Erythrocyte Membrane; Peptide Fragments; Rabbits; Reticulocytes | 1986 |
Characterization of opioid receptors on isolated canine gallbladder smooth muscle cells.
Topics: Animals; Benzomorphans; Dogs; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gallbladder; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Receptors, Opioid | 1988 |
Central mu, delta- and kappa-opioid influences on intestinal water and electrolyte transport in dogs.
Topics: Animals; Body Water; Cerebral Ventricles; Cholera Toxin; Dogs; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Intestinal Absorption; Potassium; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sodium; Vagotomy | 1988 |
Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization.
Topics: Animals; DNA; Dynorphins; Enkephalin, Methionine; Enkephalins; Hyperalgesia; Hyperesthesia; Male; Nucleic Acid Hybridization; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1988 |
Enkephalin is liberated from metorphamide and dynorphin A1-8 by endo-oligopeptidase A, but not by metalloendopeptidase EC 3.4.24.15.
Topics: Chemical Precipitation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dynorphins; Enkephalin, Methionine; Enkephalins; Metalloendopeptidases; Peptide Fragments | 1988 |
Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats.
Topics: Animals; Cats; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Narcotic Antagonists; Narcotics; Peptide Fragments; Stomach; Vagus Nerve | 1988 |
The isolation and chemical characterization of phosphorylated enkephalin-containing peptides from bovine adrenal medulla.
Topics: Adrenal Medulla; Alkaline Phosphatase; Amino Acid Sequence; Animals; Cattle; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Enkephalin, Methionine; Enkephalins; Molecular Sequence Data; Peptide Fragments; Phosphates; Phosphorylation; Protein Precursors | 1989 |
Neurotensin affects metabolism of opioid peptides, catecholamines and inositol phospholipids in bovine chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Inositol Phosphates; Neurotensin; Norepinephrine; Sugar Phosphates | 1989 |
Attenuation of the osmotic release of vasopressin by enkephalins in dogs.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Female; Heart Rate; Infusions, Intravenous; Kinetics; Male; Osmolar Concentration; Potassium; Reference Values; Sodium | 1989 |
Association of endogenous synenkephalin containing peptides with intracellular membranes of bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Cattle; Chemical Phenomena; Chemistry, Physical; Chromaffin Granules; Chromatography, Gel; Digitonin; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Intracellular Membranes; Microsomes; Molecular Weight; Octoxynol; Osmolar Concentration; Polyethylene Glycols; Protein Precursors; Sodium Dodecyl Sulfate; Thiocyanates | 1989 |
Decreased plasma enkephalins in copper deficiency in man.
Topics: beta-Endorphin; Catecholamines; Ceruloplasmin; Copper; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Male; Superoxide Dismutase | 1986 |
Pharmacological evidence of a central effect of naltrexone, morphine, and beta-endorphin and a peripheral effect of met- and leu-enkephalin on retention of an inhibitory response in mice.
Topics: Adrenal Medulla; Animals; Avoidance Learning; beta-Endorphin; Brain; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Memory; Mice; Morphine; Naltrexone; Quaternary Ammonium Compounds; Retention, Psychology | 1985 |
Release of immunoreactive met-enkephalin by intraventricular beta-endorphin in anesthetized rats.
Topics: Animals; beta-Endorphin; Brain; Brain Stem; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Kinetics; Male; Perfusion; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Tissue Distribution | 1986 |
Altered beta-endorphin, Met- and Leu-enkephalins, and enkephalin-containing peptides in pancreas and pituitary of genetically obese diabetic (db/db) mice during development of diabetic syndrome.
Topics: Aging; Animals; beta-Endorphin; Body Weight; Diabetes Mellitus, Experimental; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Insulin; Islets of Langerhans; Mice; Mice, Obese; Pituitary Gland | 1986 |
[Immunocytochemical detection of substances related to methionine enkephalin in the tentacles and food of the snail (Helix aspersa)].
Topics: Animals; Enkephalin, Methionine; Enkephalins; Helix, Snails; Immunologic Techniques | 1986 |
Opioid peptides in the regulation of TSH and prolactin secretion in the rat.
Topics: Animals; beta-Endorphin; Cold Temperature; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Injections, Intraventricular; Male; Prolactin; Rats; Rats, Inbred Strains; Thyrotropin | 1987 |
Involvement of endogenous opiates in glucose-stimulated hyperinsulinism of canine endotoxin shock. Inhibition by naloxone.
Topics: Animals; beta-Endorphin; Blood Glucose; Dogs; Endorphins; Endotoxins; Enkephalin, Leucine; Enkephalin, Methionine; Escherichia coli; Glucose; Hyperinsulinism; Insulin; Kinetics; Male; Naloxone; Shock, Septic | 1987 |
Central nervous system actions of beta-endorphin on gastric acid secretion.
Topics: Animals; Autonomic Nervous System; beta-Endorphin; Brain; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gastric Acid; Injections, Intraventricular; Male; Naloxone; Pentagastrin; Vagus Nerve | 1987 |
Enkephalins in the rat pituitary gland: immunohistochemical and biochemical observations.
Topics: Animals; beta-Endorphin; Chromatography, Gel; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Histocytochemistry; Male; Pituitary Gland; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Tissue Distribution | 1987 |
Modulation by endogenous opioid peptides of the secretion of LHRH from cockerel (Gallus domesticus) mediobasal hypothalamic tissue.
Topics: Animals; beta-Endorphin; Chickens; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Naloxone | 1987 |
Beta-endorphin modulation of mitogen-stimulated calcium uptake by rat thymocytes.
Topics: Animals; beta-Endorphin; Calcium; Concanavalin A; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Male; Mitogens; Phytohemagglutinins; Rats; Rats, Inbred Strains; T-Lymphocytes | 1987 |
The effect of enkephalins and of beta-endorphin on the hypertensive response to physostigmine in the rat.
Topics: Animals; beta-Endorphin; Blood Pressure; Catecholamines; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Physostigmine; Rats; Rats, Inbred Strains | 1987 |
Sympathoadrenal activity and sympathoinhibitory hormones during acute and chronic nicotine application in dogs.
Topics: Animals; Arousal; Atrial Natriuretic Factor; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Female; Heart Rate; Infusions, Intravenous; Male; Neural Inhibition; Nicotine; Norepinephrine; Sympathetic Nervous System | 1988 |
Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms.
Topics: Analgesia; Animals; Blood Gas Analysis; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Respiration | 1985 |
Pulmonary metabolism of exogenous enkephalins in isolated perfused rat lungs.
Topics: Aminopeptidases; Animals; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Leucine; Lung; Male; Oligopeptides; Peptidyl-Dipeptidase A; Perfusion; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Modulation of cholinergic neurotransmission in airways by enkephalin.
Topics: Acetylcholine; Animals; Depression, Chemical; Dogs; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Propranolol; Receptors, Opioid; Synaptic Transmission; Trachea | 1985 |
Separation of kappa-opioid receptor subtype from frog brain.
Topics: Animals; Brain Chemistry; Centrifugation, Density Gradient; Chromatography, Gel; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Comparative studies of the binding of dimeric and monomeric enkephalins to neuroblastoma-glioma NG108-15 cells.
Topics: Animals; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Neuroblastoma; Receptors, Opioid; Tritium | 1985 |
Characterization of rat brain opioid receptors by [Tyr-3,5-3H]1, D-Ala2, Leu5-enkephalin binding.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Methionine; Enkephalins; Kinetics; Rats; Receptors, Opioid; Tritium | 1985 |
Effect of [D-Ala2,Met5]enkephalinamide and [D-Ala2,D-Leu5]enkephalin on cholinergic and noradrenergic neurotransmission in isolated atria.
Topics: Acetylcholine; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Naloxone; Norepinephrine; Rabbits; Rats; Synaptic Transmission; Tetrodotoxin | 1985 |
The proenkephalin A fragment, peptide E: central processing and CNS activity in vivo.
Topics: Animals; Brain; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Urinary Bladder | 1985 |
Evidence for the epsilon-type of opioid receptor in the rat vas deferens.
Topics: Animals; Binding, Competitive; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Synergism; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Fentanyl; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens | 1985 |
Conversion and inactivation of opioid peptides by rabbit brain endo-oligopeptidase A.
Topics: Amino Acids; Animals; Bradykinin; Brain; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Precursors; Rabbits | 1985 |
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: I. Interaction with delta and mu sites.
Topics: Adrenal Medulla; Animals; Binding Sites; Cattle; Cesium; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylmaleimide; Kinetics; Lithium; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium; Stereoisomerism | 1985 |
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: II. Interaction with kappa sites.
Topics: Adrenal Medulla; Animals; Benzomorphans; Binding Sites; Calcium; Cattle; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Ethylmaleimide; Etorphine; Guinea Pigs; Kinetics; Lithium; Manganese; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, kappa; Sodium; Stereoisomerism | 1985 |
Regulation of ventilation and oxygen consumption by delta- and mu-opioid receptor agonists.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Naloxone; Oxygen; Oxygen Consumption; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
An opiate receptor-associated aminopeptidase that degrades enkephalins.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Brain; Chromatography, Affinity; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naltrexone; Oligopeptides; Peptides; Rats; Receptors, Opioid | 1985 |
Opioid activity of pro-enkephalin-derived peptides in mouse vas deferens and guinea pig ileum.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Myenteric Plexus; Peptides; Protein Precursors; Receptors, Opioid; Vas Deferens | 1985 |
Sex-dependent effects of neonatally administered morphiceptin and D-ala-D-leu-enkephalin on maze learning in rats.
Topics: Animals; Cerebral Ventricles; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Learning; Male; Motor Activity; Rats; Reaction Time; Receptors, Opioid; Receptors, Opioid, mu; Sex Characteristics | 1985 |
[Cerebrovascular effects of met- and leu-enkephalins].
Topics: Animals; Blood Pressure; Cats; Cerebrovascular Circulation; Enkephalin, Leucine; Enkephalin, Methionine; Naloxone; Rabbits; Receptors, Opioid; Reflex; Sympathetic Nervous System; Vasoconstriction | 1986 |
Role of endogenous opiates and extracellular K+ accumulation in the inhibition of frog spinal reflexes by electrical skin stimulation.
Topics: Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Extracellular Space; Hindlimb; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Neural Inhibition; Neurons, Afferent; Potassium; Rana temporaria; Reflex; Skin Physiological Phenomena; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1985 |
Expression of the human proenkephalin gene in mouse pituitary cells: accurate and efficient mRNA production and proteolytic processing.
Topics: Adrenocorticotropic Hormone; Animals; Cell Line; DNA Restriction Enzymes; Enkephalin, Methionine; Enkephalins; Genes; Humans; Mice; Pituitary Neoplasms; Plasmids; Pro-Opiomelanocortin; Protein Biosynthesis; Protein Precursors; RNA, Messenger; Species Specificity; Transcription, Genetic | 1985 |
Quantitative autoradiographic analysis of mu and delta opioid binding sites in the rat hippocampal formation.
Topics: Animals; Autoradiography; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Demonstration of corticotropin-releasing factor binding sites on human and rat erythrocyte membranes and their modulation by chronic ethanol treatment in rats.
Topics: Animals; Binding Sites; Corticotropin-Releasing Hormone; Enkephalin, Leucine; Enkephalin, Methionine; Erythrocyte Membrane; Ethanol; Humans; Kinetics; Magnesium; Magnesium Chloride; Male; Prolactin; Rats; Receptors, Cell Surface; Receptors, Corticotropin-Releasing Hormone; Temperature; Time Factors; Tissue Distribution | 1986 |
Interaction of enkephalins and des-tyrosyl-enkephalins with synaptosomal plasma membrane vesicles: enkephalin binding and inhibition of proline transport.
Topics: Amino Acids; Animals; Biological Transport; Cell Membrane; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kinetics; Naloxone; Proline; Receptors, Opioid; Structure-Activity Relationship; Synaptosomes | 1986 |
Simultaneous determination of radio-immunoassayable methionine-enkephalin and radioreceptor-active opiate peptides in CSF of chronic pain suffering and non suffering patients.
Topics: Adolescent; Adult; Aged; Animals; Chronic Disease; Enkephalin, Methionine; Enkephalins; Female; Humans; Intervertebral Disc Displacement; Kinetics; Male; Middle Aged; Pain, Intractable; Radioimmunoassay; Rats; Receptors, Opioid | 1986 |
Morphine tolerance increases mu-noncompetitive delta binding sites.
Topics: Animals; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Kinetics; Morphine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
The in vitro and in vivo effects of enkephalins and beta-endorphin on ACE activity in mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; beta-Endorphin; Brain; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Lung; Mice; Mice, Inbred Strains; Naloxone; Peptidyl-Dipeptidase A | 1986 |
[Synthesis and analysis of des-Met5-[D-Ala2]enkephalinamide analogs].
Topics: Amino Acids; Analgesics; Animals; Circular Dichroism; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth; Oligopeptides; Rats; Receptors, Opioid; Structure-Activity Relationship | 1986 |
Proenkephalin-A gene regulation in the rat striatum: influence of lithium and haloperidol.
Topics: Animals; Chlorides; Corpus Striatum; DNA; Enkephalin, Methionine; Enkephalins; Haloperidol; Hippocampus; Hypothalamus; Kinetics; Lithium; Lithium Chloride; Male; Nucleic Acid Hybridization; Protein Biosynthesis; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger | 1986 |
Interaction of dimeric and monomeric enkephalins with NG108-15 hybrid cells. A kinetic analysis.
Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hybrid Cells; Kinetics; Mice; Rats; Receptors, Opioid | 1986 |
Action at the mu receptor is sufficient to explain the supraspinal analgesic effect of opiates.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Protein Precursors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1986 |
Studies of kappa agonist.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Humans; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Glucocorticoids and cyclic AMP synergistically regulate the abundance of preproenkephalin messenger RNA in neuroblastoma-glioma hybrid cells.
Topics: Base Sequence; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Glioma; Glucocorticoids; Hybrid Cells; Neuroblastoma; Protein Precursors; RNA, Messenger | 1986 |
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1986 |
The effect of enkephalins and prostaglandins on O-2 release by neutrophils.
Topics: Dinoprostone; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Structure-Activity Relationship; Superoxides | 1986 |
Increased food intake after opioid microinjections into nucleus accumbens and ventral tegmental area of rat.
Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Enkephalin, Methionine; Enkephalins; Feeding Behavior; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei; Tegmentum Mesencephali | 1986 |
Naloxazone treatment in the guinea pig ileum in vitro reveals second functional opioid receptor site.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Male; Mathematics; Naloxone; Receptors, Opioid; Time Factors | 1987 |
A novel proenkephalin processing carboxypeptidase and its activation by cyclic AMP dependent protein kinase.
Topics: Animals; Carboxypeptidase B; Carboxypeptidases; Cattle; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; Protein Kinases; Protein Precursors; Rats; Synaptosomes | 1987 |
Audiogenic seizures during ethanol withdrawal can be blocked by a delta opioid agonist.
Topics: Acoustic Stimulation; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethanol; Female; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome | 1986 |
Enkephalins inhibit non-adrenergic, non-cholinergic neuromuscular transmission in the human colon.
Topics: Colon; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Neuromuscular Junction; Synaptic Transmission | 1986 |
Enkephalin in the goldfish retina.
Topics: Animals; Autoradiography; Cyprinidae; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Goldfish; Histocytochemistry; Immunochemistry; Receptors, Opioid; Retina; Sulfur Radioisotopes; Tritium | 1986 |
Presynaptic opioid delta-receptors in the rabbit mesenteric artery.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Narcotic Antagonists; Neuromuscular Junction; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Yohimbine | 1986 |
Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Motor Activity; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tegmentum Mesencephali | 1987 |
Interaction of met-enkephalin with human granulocytes.
Topics: Cell Movement; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Neutrophils; Receptors, Opioid | 1987 |
[Opioid activity of peptides and wound healing of the skin].
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Skin; Wound Healing | 1987 |
Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Naloxone; Protein Precursors; Radioligand Assay; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hippocampus; In Vitro Techniques; Male; Naloxone; Rats; Rats, Inbred Strains | 1988 |
Neuropeptides in synovium of patients with rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Calcitonin; Calcitonin Gene-Related Peptide; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Immunoenzyme Techniques; Intermediate Filaments; Neuropeptides; Osteoarthritis; Synovial Membrane | 1988 |
Three-dimensional analyses of the binding of synthetic chemotactic and opioid peptides in the Mcg light chain dimer.
Topics: Amyloidosis; Binding Sites; Chemotactic Factors; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Immunoglobulin Light Chains; Peptides; Protein Conformation; X-Ray Diffraction | 1986 |
Enkephalin conformation in solution: a perspective from vibrational spectroscopic studies.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Models, Molecular; Protein Conformation; Solutions; Spectrophotometry, Infrared; Spectrum Analysis, Raman; Structure-Activity Relationship; Vibration | 1986 |
Isolation and identification of opioid peptides.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Cattle; Chickens; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Radioimmunoassay; Structure-Activity Relationship | 1986 |
Analgesic properties of valproic acid might be related to activation of pro-enkephalin system in rat brain.
Topics: Analgesics; Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Male; Rats; Rats, Inbred Strains; Valproic Acid | 1987 |
Plasma met-enkephalin and leu-enkephalin in chronic renal failure.
Topics: Adult; Blood; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Kidney Failure, Chronic; Middle Aged; Renal Dialysis; Ultrafiltration | 1987 |
Enkephalin-like immunoreactivity in the adult rats corpus luteum.
Topics: Animals; Corpus Luteum; Cytoplasm; Enkephalin, Leucine; Enkephalin, Methionine; Female; Immunoenzyme Techniques; Ovarian Follicle; Rats; Rats, Inbred Strains | 1986 |
Characterization of enkephalin-immunoreactive peptides generated by peptic digestion of rat plasma proteins.
Topics: Animals; Blood Proteins; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Female; Isoelectric Focusing; Isoelectric Point; Molecular Weight; Pepsin A; Radioimmunoassay; Rats; Serum Albumin | 1988 |
Enkephalin inhibits dopamine synthesis in vitro in the median eminence portion of rat hypothalamic slices.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Calcium; Dihydroxyphenylalanine; Dopamine; Enkephalin, Methionine; Enkephalins; Female; Haloperidol; Hypothalamus; In Vitro Techniques; Median Eminence; Neurons; Rats; Rats, Inbred Strains | 1988 |
L-deprenyl in prevention of MPTP induced depletion of striatal enkephalins in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Stereoisomerism | 1988 |
Expression of the enkephalin precursor gene in rat Sertoli cells. Regulation by follicle-stimulating hormone.
Topics: Actins; Animals; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Follicle Stimulating Hormone; Gene Expression Regulation; Genes; Kinetics; Male; Protein Precursors; Rats; Reference Values; RNA, Messenger; Sertoli Cells; Transcription, Genetic | 1988 |
[Influence of electroacupuncture and antagonism of electroacupuncture analgesia by naloxone on enkephalin-like immunoreactivity in guinea pig's adrenal and spinal cord].
Topics: Acupuncture Therapy; Adrenal Glands; Analgesia; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Immunohistochemistry; Male; Naloxone; Pain; Sensory Thresholds; Spinal Cord | 1988 |
[Experimental research on the yin-yang theory in traditional Chinese medicine (III). The effect of monkshood, bark of the Chinese cassia tree and liu wei di huang fang on the enkephalin of brain tissue in renovascular hypertensive rats].
Topics: Aconitum; Animals; Brain; Brain Chemistry; Cassia; Enkephalin, Leucine; Enkephalin, Methionine; Hypertension, Renovascular; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains | 1985 |
Secondary neuroendocrine carcinomas of the skin. An immunohistochemical comparison with primary neuroendocrine carcinoma of the skin ("Merkel cell" carcinoma).
Topics: Adult; Aged; beta-Endorphin; Bombesin; Carcinoid Tumor; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Phosphopyruvate Hydratase; Skin; Skin Neoplasms | 1985 |
Characterization of 1,1-dimethyl-4-phenylpiperazinium induced increased proenkephalin processing in bovine chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Dimethylphenylpiperazinium Iodide; Enkephalin, Methionine; Enkephalins; Piperazines; Protein Precursors; Protein Processing, Post-Translational; Reference Values | 1988 |
Morphine alters preproenkephalin gene expression.
Topics: Animals; Corpus Striatum; Drug Implants; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Male; Morphine; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Substance Withdrawal Syndrome | 1988 |
Enkephalin-like immunoreactive principal ganglion cells and nerve fibres in the inferior mesenteric ganglion of the cat.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Methionine; Female; Ganglia, Sympathetic; Immunohistochemistry; Male | 1988 |
Suppression of anaphylactic shock by enkephalins.
Topics: Anaphylaxis; Animals; Antibody Formation; Enkephalin, Leucine; Enkephalin, Methionine; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats | 1988 |
[The effect of methionine enkephalin, leucine enkephalin and the hexapeptide, dalargin on the morphology of cultured neurons].
Topics: Animals; Brain; Cell Division; Cells, Cultured; Chick Embryo; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Microscopy, Electron, Scanning; Neurons; Rats; Retina | 1988 |
Enkephalin activity on antigen-induced proliferation of human peripheral blood mononucleate cells.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lymphocyte Activation; Oligopeptides | 1988 |
Simultaneous analysis of methionine- and leucine-enkephalin from rat brain: quantification by liquid chromatography-electrochemistry.
Topics: Animals; Brain Chemistry; Chromatography, Liquid; Electrochemistry; Enkephalin, Leucine; Enkephalin, Methionine; Indicators and Reagents; Male; Rats; Rats, Inbred Strains | 1988 |
Excitatory effects of opiates on the spontaneous EMG activity in pigeon oesophagus.
Topics: Animals; Columbidae; Electromyography; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Esophagus; Morphine; Muscle, Smooth | 1988 |
Effect of enkephalin analogues Tyr-D-Ala-Gly-Phe-Cys(Et) and Tyr-D-Ala-Gly-Phe-Cys(Bu) on prolactin and growth hormone release in rats.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Growth Hormone; Male; Prolactin; Rats; Rats, Inbred Strains | 1988 |
Interaction between opioid agonists or naloxone and 5-HTP on feeding behavior in food-deprived rats.
Topics: 5-Hydroxytryptophan; Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Feeding Behavior; Food Deprivation; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains | 1988 |
The distribution of proenkephalin-derived peptides in the central nervous system of turtles.
Topics: Animals; Antibody Specificity; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Histocytochemistry; Immune Sera; Immunologic Techniques; Peptides; Protein Precursors; Turtles | 1987 |
[Influence of captopril on the in vitro and in vivo effects of leu- and met-enkephalins].
Topics: Animals; Captopril; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Enkephalin, Leucine; Enkephalin, Methionine; Female; Guinea Pigs; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Pain; Time Factors | 1987 |
Enkephalins and immunity. I: In vivo suppression and potentiation of humoral immune response.
Topics: Adjuvants, Immunologic; Anaphylaxis; Animals; Antibody Formation; Enkephalin, Leucine; Enkephalin, Methionine; Hemolytic Plaque Technique; Immunosuppression Therapy; Male; Mice; Mice, Inbred BALB C; Naloxone; Rats; Rats, Inbred Strains | 1987 |
Affinity purification of synenkephalin-containing peptides, including a novel 23.3-kilodalton species.
Topics: Animals; Cattle; Chromatography, Affinity; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Immunosorbent Techniques; Molecular Weight; Protein Precursors | 1987 |
Nicotinic receptor stimulation enhances enkephalin-like peptides processing in chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; Carboxypeptidase B; Carboxypeptidases; Cattle; Chromaffin System; Dimethylphenylpiperazinium Iodide; Enkephalin, Methionine; Enkephalins; Methacholine Chloride; Methacholine Compounds; Potassium; Protein Precursors; Radioimmunoassay; Receptors, Nicotinic; Trypsin | 1987 |
Comparative immunohistochemical demonstration of peptide F- and other enkephalin-containing neurons in the enteric nervous system of the rat.
Topics: Animals; Digestive System; Enkephalin, Methionine; Enkephalins; Esophagus; Fluorescent Antibody Technique; Immune Sera; Male; Neurons; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values | 1987 |
Differential release of enkephalin and enkephalin-containing peptides from perfused cat adrenal glands.
Topics: Acetylcholine; Adrenal Glands; Animals; Cats; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Female; Male; Molecular Weight; Nicotine; Pilocarpine; Potassium; Receptors, Muscarinic | 1988 |
Solution and membrane structure of enkephalins as studied by infrared spectroscopy.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Lipid Bilayers; Phosphatidylcholines; Protein Conformation; Solutions; Spectrophotometry, Infrared; Water | 1988 |
Mapping of enkephalin-related peptides in the nervous system of the blowfly, Calliphora vomitoria, and their co-localization with cholecystokinin (CCK)- and pancreatic polypeptide (PP)-like peptides.
Topics: Animals; Brain; Cholecystokinin; Diptera; Enkephalin, Leucine; Enkephalin, Methionine; Female; Ganglia; Immunohistochemistry; Male; Nervous System; Pancreatic Polypeptide | 1988 |
Enkephalin precursor gene expression in postmeiotic germ cells.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Genes; Male; Nucleic Acid Hybridization; Protein Precursors; Rats; RNA, Messenger; Spermatids; Testis; Transcription, Genetic | 1988 |
Catecholamine innervation of enkephalinergic neurons in guinea pig hypothalamus: demonstration by an in vitro autoradiographic technique combined with a post-embedding immunogold method.
Topics: Animals; Autoradiography; Dopamine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hypothalamus; Immunohistochemistry; Male; Microscopy, Electron; Neurons; Norepinephrine | 1988 |
N-linked glycosylation of a proenkephalin A-derived peptide. Evidence for the glycosylation of an NH2-terminally extended Met-enkephalin Arg6-Gly7-Leu8 variant.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Genetic Variation; Glycosylation; Molecular Sequence Data; Protein Precursors; Protein Processing, Post-Translational | 1988 |
Effect of centrally administered encephalinamides on regional cerebral blood flow in the dog.
Topics: Animals; Brain; Cerebrovascular Circulation; Cisterna Magna; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Injections; Male; Regional Blood Flow; Tissue Distribution | 1988 |
Characterization of enkephalins in rat adrenal medullary explants.
Topics: Adrenal Medulla; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Molecular Weight; Potassium; Protein Precursors; Rats; Rats, Inbred Strains; Time Factors | 1988 |
[Enkephalins and their synthetic analogs as noncompetitive reversible inhibitors of acetylcholinesterase].
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Kinetics; Structure-Activity Relationship | 1988 |
Tissue content of opioid peptides in the myenteric plexus-longitudinal muscle of guinea-pig small intestine.
Topics: Animals; Biological Assay; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Intestine, Small; Male; Mice; Muscle Contraction; Myenteric Plexus; Naloxone; Protein Precursors; Tissue Distribution; Vas Deferens | 1988 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Characterisation of N-terminally extended met-enkephalin Arg6Gly7Leu8 variants in the porcine upper digestive tract.
Topics: Amino Acid Sequence; Animals; Duodenum; Enkephalin, Methionine; Enkephalins; Protein Precursors; Pyloric Antrum; Pylorus; Stomach; Swine | 1988 |
Adrenal proenkephalin-derived peptides during postnatal development in spontaneously hypertensive rats.
Topics: Adrenal Glands; Aging; Animals; Chlorisondamine; Chromatography, Gel; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypertension; Male; Molecular Weight; Protein Precursors; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1988 |
Neuropeptide Y is localized together with enkephalins in adrenergic granules of bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Cattle; Centrifugation, Isopycnic; Chromaffin Granules; Chromaffin System; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Immunohistochemistry; Neuropeptide Y | 1988 |
Roles of the pituitary-adrenocortical axis in control of the native and cryptic enkephalin levels and proenkephalin mRNA in the sympathoadrenal system of the rat.
Topics: Adrenal Medulla; Animals; Dexamethasone; Enkephalin, Methionine; Enkephalins; Ganglia, Sympathetic; Hypophysectomy; Male; Pituitary-Adrenal System; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger | 1988 |
[Reduction of the rate of mitochondrial respiration in the rat heart perfused with opioids and naloxone].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Male; Mitochondria, Heart; Morphine; Naloxone; Oxygen Consumption; Perfusion; Rats; Rats, Inbred Strains | 1988 |
Proenkephalin A-derived peptides in the human gut.
Topics: Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Intestinal Mucosa; Intestines | 1988 |
[D-Met2,Pro5] enkephalin [N1.5-beta-D-glucopyranosyl] amide: a glycosylpeptide with high antinociceptive activity.
Topics: Analgesics; Animals; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Muscle, Smooth; Pain; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1988 |
Selective cleavage of proenkephalin-derived peptides (less than 23,300 daltons) by plasma kallikrein.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Cattle; Chromaffin Granules; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Enkephalin, Methionine; Enkephalins; Humans; Hydrolysis; Immunoassay; Kallikreins; Kinetics; Molecular Sequence Data; Molecular Weight; Peptides; Protein Precursors; Radioimmunoassay; Substrate Specificity | 1988 |
Proenkephalin A processing in the upper digestive tract: isolation and characterisation of phosphorylated N-terminally extended Met-enkephalin Arg6Phe7 variants.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Duodenum; Enkephalin, Methionine; Enkephalins; Gastric Mucosa; Molecular Sequence Data; Phosphorylation; Protein Precursors; Pyloric Antrum; Radioimmunoassay; Swine | 1988 |
IR-Met and IR-Leu enkephalin content in the axolotl brain (Ambystoma mexicanum).
Topics: Ambystoma mexicanum; Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine | 1988 |
Quantification and characterization of enkephalins in the upper part of the cat digestive tract and the coeliac ganglia.
Topics: Animals; Cats; Chromatography, High Pressure Liquid; Digestive System; Enkephalin, Leucine; Enkephalin, Methionine; Female; Ganglia, Sympathetic; Male; Radioimmunoassay | 1988 |
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility).
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin | 1988 |
Separation of carboxypeptidase A and B from longitudinal muscle layer of bovine small intestine: their properties regarding hydrolysis of enkephalins and enkephalin-analogs.
Topics: Animals; Carboxypeptidase B; Carboxypeptidases; Carboxypeptidases A; Cattle; Enkephalin, Leucine; Enkephalin, Methionine; Intestine, Small; Kinetics; Myenteric Plexus | 1987 |
The crystal structures of [Met5]enkephalin and a third form of [Leu5]enkephalin: observations of a novel pleated beta-sheet.
Topics: Crystallography; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hydrogen Bonding; Protein Conformation | 1986 |
Effect of norepinephrine on canine plasma concentrations of enkephalin-like material.
Topics: Adrenalectomy; Animals; Blood Flow Velocity; Blood Pressure; Dinoprost; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mesenteric Arteries; Mesenteric Veins; Norepinephrine; Prostaglandins F; Radioimmunoassay; Time Factors; Vasopressins | 1987 |
Influence of opiates on alkali secretion by amphibian gastric and duodenal mucosa in vitro.
Topics: Alkalies; Animals; Duodenum; Enkephalin, Leucine; Enkephalin, Methionine; Gastric Acid; Gastric Mucosa; Intestinal Mucosa; Morphine; Naloxone; Narcotics; Rana catesbeiana; Rana temporaria; Stimulation, Chemical | 1986 |
Kinetics of four 11C-labelled enkephalin peptides in the brain, pituitary and plasma of rhesus monkeys.
Topics: Animals; Biological Transport, Active; Brain; Enkephalin, Methionine; Enkephalins; Kinetics; Macaca mulatta; Pituitary Gland; Tomography, Emission-Computed | 1986 |
Effects of enkephalin, applied intracellularly, on action potentials in vertebrate A and C nerve fibre axons.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; In Vitro Techniques; Naloxone; Nerve Fibers; Nerve Fibers, Myelinated; Rabbits; Rana pipiens; Sciatic Nerve; Vagus Nerve | 1987 |
Enkephalins and immunity. II: In vivo modulation of cell-mediated immunity.
Topics: Adjuvants, Immunologic; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Immunity, Cellular; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred Lew; Rats, Inbred Strains; T-Lymphocytes; Thyroid Gland; Transplantation, Homologous | 1987 |
Enkephalins and autoimmunity: differential effect of methionine-enkephalin on experimental allergic encephalomyelitis in Wistar and Lewis rats.
Topics: Animals; Autoimmune Diseases; Encephalomyelitis, Autoimmune, Experimental; Enkephalin, Leucine; Enkephalin, Methionine; Male; Rats; Rats, Inbred Lew; Rats, Inbred Strains | 1987 |
Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?
Topics: Animals; Basal Ganglia; Biogenic Monoamines; Burns; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Locomotion; Male; Pain; Rats; Rats, Inbred Strains; Rest; Sensory Thresholds; Time Factors | 1986 |
Opioid peptides in rat islets of Langerhans. Immunoreactive met- and leu-enkephalins and BAM-22P.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Islets of Langerhans; Male; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains | 1986 |
Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin.
Topics: Amino Acid Sequence; Animals; Bacteria; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Kidney; Kinetics; Neprilysin; Oligopeptides; Rats; Substrate Specificity; Thermolysin | 1986 |
Immunocytochemical localization of proenkephalin-derived peptides in the central nervous system of the rat.
Topics: Animals; Brain; Enkephalin, Methionine; Enkephalins; Hypothalamus; Immunoenzyme Techniques; Mesencephalon; Neurons; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Inbred Strains; Spinal Cord; Telencephalon; Thalamus | 1986 |
Effect of endorphins on heart rate and blood pressure in adult dogs.
Topics: Animals; Atropine; Blood Pressure; Consciousness; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; Heart Rate; Naloxone; Naltrexone | 1986 |
Opioid mydriasis: cross-tolerance between morphine and enkephalins.
Topics: Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Pupil | 1986 |
Distribution and development of proenkephalin-like immunoreactivity in the lumbar spinal cord of the chicken.
Topics: Animals; Chemical Phenomena; Chemistry; Chickens; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Protein Precursors; Spinal Cord | 1986 |
[Met]- and [Leu]enkephalin-like immunoreactive cell bodies and nerve fibres in the coeliac ganglion of the cat.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Methionine; Female; Ganglia, Sympathetic; Immunoenzyme Techniques; Male; Nerve Fibers | 1986 |
Reflex splanchnic nerve stimulation increases levels of proenkephalin A mRNA and proenkephalin A-related peptides in the rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Catecholamines; Enkephalin, Methionine; Enkephalins; Hypoglycemia; Insulin; Male; Nucleic Acid Hybridization; Parasympatholytics; Protein Precursors; Rats; Reflex; RNA, Messenger; Splanchnic Nerves | 1986 |
Immunohistochemical localization of enkephalinlike peptides during testicular development in rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Histocytochemistry; Immunologic Techniques; Male; Rats; Rats, Inbred Strains; Seminiferous Tubules; Sexual Maturation; Testis | 1986 |
Localization of enkephalin immunoreactivity in diverse tissues and cells of the developing and adult rat.
Topics: Animals; Cell Differentiation; Cell Division; Cell Nucleus; Cytoplasm; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fluorescent Antibody Technique; Growth; Histocytochemistry; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1986 |
Synenkephalin in bovine and human spinal cord.
Topics: Animals; Cattle; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Histocytochemistry; Humans; Immunoenzyme Techniques; Male; Middle Aged; Protein Precursors; Spinal Cord; Tissue Distribution | 1986 |
An immunohistochemical study of methionine-enkephalin-Arg6-Gly7-Leu8-like immunoreactivity-containing neurons in the parasympathetic preganglionic regions of the rat spinal cord.
Topics: Animals; Autonomic Fibers, Preganglionic; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Male; Parasympathetic Nervous System; Protein Precursors; Rats; Rats, Inbred Strains; Spinal Cord; Substantia Gelatinosa | 1987 |
Release of [met5]-enkephalin-arg6-gly7-leu8 immunoreactivity into rat cerebrospinal fluid by electroconvulsive shock.
Topics: Animals; Electroshock; Enkephalin, Methionine; Enkephalins; Neurons; Rats | 1987 |
Modulation of in vivo immune responses by enkephalins.
Topics: Animals; Antibody Formation; Enkephalin, Leucine; Enkephalin, Methionine; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred Strains | 1986 |
Crystal structure of an extended-conformation leucine-enkephalin dimer monohydrate.
Topics: Crystallization; Enkephalin, Leucine; Enkephalin, Methionine; Models, Molecular; Protein Conformation; X-Ray Diffraction | 1987 |
Age-related decreases in the concentration of Met- and Leu-enkephalin and neurotensin in the basal ganglia of rats.
Topics: Aging; Animals; Basal Ganglia; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Neurotensin; Radioimmunoassay; Rats; Rats, Inbred Strains | 1987 |
The antimetastatic activity of enkephalin-like peptides.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis | 1987 |
[Effects of morphine and endogenous opioids on mechanical activity of isolated and perfused rat hearts ].
Topics: Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Heart Rate; In Vitro Techniques; Morphine; Naloxone; Perfusion; Rats; Rats, Inbred Strains; Sarcolemma | 1987 |
[Modulating effect of enkephalins on hemopoieis under stress].
Topics: Animals; Bone Marrow; Enkephalin, Leucine; Enkephalin, Methionine; Hematopoiesis; Male; Mice; Restraint, Physical; Stress, Psychological; Time Factors | 1987 |
Preproenkephalin A-derived opioid peptides and mRNA of preproenkephalin A in human pheochromocytomas.
Topics: Adrenal Gland Neoplasms; Adult; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; Male; Middle Aged; Nucleic Acid Hybridization; Pheochromocytoma; Protein Precursors; Radioimmunoassay; RNA, Messenger | 1987 |
Effect of endogenous opioid peptides on acetylcholine release from the cat superior cervical ganglion: selective effect of a heptapeptide.
Topics: Acetylcholine; Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Ganglia, Sympathetic; Male | 1987 |
Neuroimmunomodulation with enkephalins: in vitro enhancement of natural killer cell activity in peripheral blood lymphocytes from cancer patients.
Topics: Adjuvants, Immunologic; Adult; Aged; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; Immunotherapy; Killer Cells, Natural; Male; Middle Aged; Neoplasms | 1987 |
Distribution pattern of metorphamide compared with other opioid peptides from proenkephalin and prodynorphin in the bovine brain.
Topics: Animals; Antibody Specificity; Brain; Cattle; Chromatography, Gel; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Protein Precursors; Rabbits; Radioimmunoassay; Tissue Distribution | 1987 |
Enkephalin release into the ventral tegmental area in response to stress: modulation of mesocorticolimbic dopamine.
Topics: Animals; Dopamine; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Septal Nuclei; Stress, Physiological; Tegmentum Mesencephali | 1987 |
Enkephalins and anaphylactic shock: modulation and prevention of shock in the rat.
Topics: Anaphylaxis; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Immunoglobulin E; Male; Mast Cells; Ovalbumin; Rats; Rats, Inbred Strains | 1987 |
Effect of primary ion beam parameters on the secondary ion emission of biomolecules from liquid matrices.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Mass Spectrometry | 1987 |
Proenkephalin gene expression in the PC12 pheochromocytoma cell line: stimulation by sodium butyrate.
Topics: Adrenal Gland Neoplasms; Animals; Butyrates; Butyric Acid; Cell Line; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Molecular Weight; Pheochromocytoma; Protein Precursors; Rats; RNA, Messenger; Stimulation, Chemical | 1987 |
Inhibition of sexual behavior in female rats by intracerebral injections of Met-enkephalin in combination with an inhibitor of enkephalin degrading enzymes.
Topics: Animals; Brain; Dipeptides; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Female; Injections, Intraventricular; Injections, Subcutaneous; Lordosis; Periaqueductal Gray; Rats; Rats, Inbred Strains; Sexual Behavior, Animal | 1987 |
Studies on peptides. CL. Syntheses of [D-His2]-analogs of enkephalin and adrenorphin and several [D-Arg2]enkephalin analogs.
Topics: Animals; Chemical Phenomena; Chemistry; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction | 1987 |
Potentiation of enkephalin action by peptidase inhibitors in rat locus ceruleus in vitro.
Topics: Analgesics; Animals; Dipeptides; Drug Synergism; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Locus Coeruleus; Neurons; Protease Inhibitors; Rats; Structure-Activity Relationship | 1987 |
Histamine affects release and biosynthesis of opioid peptides primarily via H1-receptors in bovine chromaffin cells.
Topics: Adrenal Glands; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Cimetidine; Clemastine; Cobalt; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gallopamil; Histamine; Histamine Antagonists; Nifedipine; Protein Precursors; Pyrilamine; Ranitidine; Receptors, Histamine; Receptors, Histamine H1; RNA, Messenger | 1987 |
Peptide E and its products, BAM 18 and Leu-enkephalin, in bovine adrenal medulla and cultured chromaffin cells: release in response to stimulation.
Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; Chromaffin System; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Nicotine; Peptide Fragments; Peptides; Potassium; Protein Precursors; Radioimmunoassay | 1987 |
Enkephalin hydrolysis in homogenates of various absorptive mucosae of the albino rabbit: similarities in rates and involvement of aminopeptidases.
Topics: Aminopeptidases; Animals; Cheek; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Hydrolysis; Ileum; Intestinal Mucosa; Mouth Mucosa; Mucous Membrane; Nasal Mucosa; Peptide Fragments; Rabbits; Rectum; Vagina | 1986 |
Enkephalin contents reflect noradrenergic large dense cored vesicle populations in vasa deferentia.
Topics: Animals; Cats; Cattle; Chromatography, High Pressure Liquid; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Humans; Male; Microscopy, Electron; Norepinephrine; Rabbits; Radioimmunoassay; Rats; Species Specificity; Vas Deferens | 1986 |
Hydrolysis of enkephalins in homogenates of anterior segment tissues of the albino rabbit eye.
Topics: Animals; Anterior Eye Segment; Ciliary Body; Cornea; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epithelium; Half-Life; Hydrolysis; Rabbits; Tears | 1986 |
Effects of two enkephalin analogues, morphine sulphate, dopamine and naloxone on prolactin secretion from rat anterior pituitary glands in vitro.
Topics: Animals; Depression, Chemical; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Female; Morphine; Naloxone; Narcotics; Organ Culture Techniques; Perfusion; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Effects of superfusion of morphine and enkephalins on the activity of single units in the spinal trigeminal nucleus and cuneate nucleus of cat.
Topics: Action Potentials; Animals; Cats; Electrophysiology; Enkephalin, Methionine; Enkephalins; Female; Male; Medulla Oblongata; Morphine; Naloxone; Trigeminal Nucleus, Spinal | 1986 |
Sympathetic control of adrenal secretion of enkephalins after hemorrhage in awake dogs.
Topics: Adrenal Glands; Animals; Arteries; Denervation; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Female; Hemodynamics; Hemorrhage; Male; Norepinephrine; Sympathetic Nervous System; Wakefulness | 1986 |
Characterization of the molecular forms of proenkephalin in bovine adrenal medulla and rat adrenal, brain, and spinal cord with a site-directed antiserum.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Antibody Specificity; Brain Chemistry; Cattle; Cyanogen Bromide; Enkephalin, Methionine; Enkephalins; Immune Sera; Molecular Weight; Protein Precursors; Radioimmunoassay; Rats; Spinal Cord | 1986 |
Acute and repeated administration of sulpiride alters Met-and Leu-enkephalin content of rat brain.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Substantia Nigra; Sulpiride | 1986 |
GENEVIEW and the DNACE data bus: computational tools for analysis, display and exchange of genetic information.
Topics: Animals; Base Sequence; Cattle; Computers; Enkephalin, Methionine; Enkephalins; Information Systems; Nucleic Acids; Protein Precursors; Software | 1986 |
GABAergic regulation of enkephalin in rat striatum: alterations in Met5-enkephalin level, precursor content and preproenkephalin messenger RNA abundance.
Topics: Aminooxyacetic Acid; Animals; Corpus Striatum; Cyclohexanecarboxylic Acids; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Gene Expression Regulation; Male; Protein Precursors; Rats; RNA, Messenger | 1986 |
Expression and cell type--specific processing of human preproenkephalin with a vaccinia recombinant.
Topics: Animals; Base Sequence; Chlorocebus aethiops; Enkephalin, Methionine; Enkephalins; Genetic Vectors; Humans; Mice; Protein Precursors; Rats; Recombinant Proteins; Vaccinia virus | 1986 |
A specific radioimmunoassay for [Leu] and [Met]enkephalin applied to a HPLC separation of human CSF.
Topics: Chromatography, High Pressure Liquid; Cross Reactions; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hypophysectomy; Immune Sera; Neoplasms; Pain, Intractable; Radioimmunoassay | 1986 |
Presence of met-enkephalin in bovine pituitary intraglandular colloid of intermediate lobe origin.
Topics: Amino Acid Sequence; Animals; Cattle; Enkephalin, Methionine; Enkephalins; Female; Male; Pituitary Gland; Protein Precursors; Radioimmunoassay | 1986 |
Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain.
Topics: Animals; Brain Chemistry; Chlorocebus aethiops; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Morphine; Naltrexone; Substance Withdrawal Syndrome | 1986 |
The application of mydriatic effect of enkephalins in mice as a test for screening of opioid peptides.
Topics: Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Mydriatics; Pupil | 1986 |
A new immunization procedure for obtention of anti-leucine-enkephalin antibodies. Part II. Effects of olfactory bulb removal on pro-enkephalin related peptides in rat brain.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Male; Olfactory Bulb; Organ Specificity; Rats; Rats, Inbred Strains | 1986 |
Pressor effects of systemic administration of methionine and leucine enkephalin in the conscious rat.
Topics: Animals; Atropine; Blood Pressure; Diprenorphine; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guanethidine; Heart Rate; Naloxone; Norepinephrine; Phentolamine; Propranolol; Rats | 1986 |
Alterations in [Met5]- and [Leu5]enkephalin and neurotensin content in basal ganglia induced by the long-term administration of dopamine agonist and antagonist drugs to rats.
Topics: Animals; Basal Ganglia; Bromocriptine; Carbidopa; Dopamine; Dopamine Antagonists; Enkephalin, Leucine; Enkephalin, Methionine; Levodopa; Male; Neurotensin; Pergolide; Rats; Rats, Inbred Strains; Trifluoperazine | 1986 |
Enkephalin inhibits presynaptically the contractility of urinary tract smooth muscle.
Topics: Animals; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Swine; Urinary Tract | 1987 |
Identification of a proenkephalin precursor in striatal tissue.
Topics: Animals; Chromatography, Gel; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Isoelectric Focusing; Male; Molecular Weight; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains | 1985 |
Modulation of striatal enkephalinergic neurons by antipsychotic drugs.
Topics: Animals; Brain; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Haloperidol; Humans; Hypophysectomy; Neurons; Protein Precursors; Rats; Receptors, Dopamine; Reserpine; RNA, Messenger | 1985 |
Evaluation of BW942C, a novel antidiarrheal agent, against enterotoxins of Escherichia coli and Vibrio cholerae.
Topics: Animals; Antidiarrheals; Bacterial Toxins; Biological Transport; Body Water; Cholera Toxin; Electrolytes; Enkephalin, Methionine; Enkephalins; Enterotoxins; Escherichia coli Proteins; Ileum; Male; Mice; Rabbits | 1985 |
Release of synenkephalin from neuronal terminals in vitro.
Topics: Animals; Calcium; Cattle; Enkephalin, Methionine; Enkephalins; Globus Pallidus; In Vitro Techniques; Potassium; Protein Precursors | 1985 |
Specific regulation of vasoactive intestinal polypeptide biosynthesis by phorbol ester in bovine chromaffin cells.
Topics: Animals; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Colforsin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Peptide Biosynthesis; Peptide PHI; Phorbols; Protein Precursors; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Vasoactive Intestinal Peptide | 1985 |
In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain.
Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Corpus Striatum; Dipeptides; Enkephalin, Methionine; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Mice; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1985 |
[Electroacupuncture accelerates the biogenesis of central enkephalins in the rat].
Topics: Acupuncture Therapy; Aminopeptidases; Animals; Brain; Electric Stimulation Therapy; Enkephalin, Leucine; Enkephalin, Methionine; Female; Leucine; Male; Phenylalanine; Radioimmunoassay; Rats; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1985 |
Distribution of enkephalin immunoreactivity in germinative cells of developing rat cerebellum.
Topics: Animals; Cell Differentiation; Cell Division; Cerebellum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Rats; Rats, Inbred Strains | 1985 |
Multiple populations of neuropeptide-containing cells in cultures of the bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Catecholamines; Cattle; Cells, Cultured; Colforsin; Diterpenes; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; In Vitro Techniques; Nerve Tissue Proteins; Phenylethanolamine N-Methyltransferase; Radioimmunoassay; Vasoactive Intestinal Peptide | 1985 |
Nasal delivery of polypeptides I: nasal absorption of enkephalins in rats.
Topics: Absorption; Administration, Intranasal; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Glycocholic Acid; Nasal Mucosa; Rats; Time Factors | 1985 |
Prodynorphin immunoreactivity is located in different neurons than proenkephalin immunoreactivity in the cerebral cortex of rats.
Topics: Animals; Cerebral Cortex; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Limbic System; Male; Olfactory Pathways; Protein Precursors; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1985 |
Localization of enkephalins in adrenaline cells and the nerves innervating adrenaline cells in rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Chromaffin Granules; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; Immunoenzyme Techniques; Male; Microscopy, Fluorescence; Nerve Endings; Norepinephrine; Rabbits; Rats; Rats, Inbred Strains | 1985 |
Enkephalin neurons in the guinea pig proximal colon: an immunocytochemical study using an antiserum to methionine-enkephalin-Arg6-Gly7-Leu8.
Topics: Animals; Colon; Enkephalin, Methionine; Enkephalins; Female; Guinea Pigs; Immune Sera; Immunoenzyme Techniques; Male; Myenteric Plexus; Neurons; Submucous Plexus | 1985 |
Cyanogen bromide cleavage of methionine residues as a control method for enkephalin immunocytochemistry.
Topics: Animals; Antibody Specificity; Cyanogen Bromide; Enkephalin, Leucine; Enkephalin, Methionine; Female; Histocytochemistry; Immunoenzyme Techniques; Methionine; Pituitary Gland, Posterior; Rats | 1985 |
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors.
Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Mice; Microwaves; Nalorphine; Neprilysin; Oligopeptides; Protease Inhibitors; Radioimmunoassay; Thiorphan; Tiopronin | 1985 |
[Inhibition of enkephalins degradation in the nucleus accumbens leads to potentiation of acupuncture and morphine analgesia].
Topics: Acupuncture Therapy; Aminopeptidases; Analgesia; Animals; Electric Stimulation Therapy; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Morphine; Neprilysin; Nucleus Accumbens; Protease Inhibitors; Rabbits; Septal Nuclei; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1985 |
Cloning and expression in Escherichia coli of the synthetic proenkephalin analogue gene.
Topics: Animals; Antigens, Viral, Tumor; beta-Galactosidase; Cloning, Molecular; DNA, Recombinant; Enkephalin, Methionine; Enkephalins; Escherichia coli; Gene Expression Regulation; Molecular Weight; Oligodeoxyribonucleotides; Protein Biosynthesis; Protein Precursors | 1985 |
[Changes in the met- and leu-enkephalin levels in the rat brain during burn shock].
Topics: Animals; Brain; Burns; Cerebral Cortex; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Rats; Shock, Traumatic; Time Factors | 1986 |
Metorphamide levels in chromaffin cells increase after treatment with reserpine.
Topics: Adrenal Glands; Animals; Cattle; Cells, Cultured; Chromaffin System; Enkephalin, Leucine; Enkephalin, Methionine; Potassium; Reserpine | 1986 |
Central and peripheral control of gastrointestinal and colonic motility by endogenous opiates in conscious dogs.
Topics: Animals; Central Nervous System; Colon; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gastrointestinal Motility; Peripheral Nerves | 1985 |
Distribution of immunoreactive Met-enkephalin-Arg6-Gly7-Leu8 and Leu-enkephalin in discrete regions of the rat brain.
Topics: Animals; Brain Chemistry; Brain Stem; Diencephalon; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Telencephalon | 1985 |
Does nitrous oxide induce release of brain opioid peptides?
Topics: Animals; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Nitrous Oxide; Radioimmunoassay; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Conformational states of Leu5- and Met5-enkephalins in solution.
Topics: Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Fourier Analysis; Protein Conformation; Solutions; Spectrophotometry, Infrared; Spectrum Analysis, Raman | 1985 |
Opioid pathways in an avian retina. I. The content, biosynthesis, and release of Met5-enkephalin.
Topics: Animals; Chickens; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Methionine; Enkephalins; Enzyme-Linked Immunosorbent Assay; Retina | 1985 |
[Effect of enkephalins on the motor function of smooth-muscle cells of the stomach and mesenteric lymphatic vessels].
Topics: Animals; Cattle; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Methionine; Gastrointestinal Motility; In Vitro Techniques; Lymphatic System; Male; Mesentery; Muscle Contraction; Muscle, Smooth; Peristalsis; Rats; Stomach | 1985 |
Interactions between enkephalin and dopamine in the control of locomotor activity in the rat: a new hypothesis.
Topics: Amphetamine; Animals; Dopamine; Drug Interactions; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Motor Activity; Naloxone; Pimozide; Rats; Rats, Inbred Strains; Time Factors | 1985 |
The stimulation of glycogenolysis in isolated hepatocytes by opioid peptides.
Topics: Angiotensin II; Animals; Calcium; Dihydroergotamine; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Glucagon; In Vitro Techniques; Lactates; Lactic Acid; Liver; Liver Glycogen; Male; Propranolol; Rats; Rats, Inbred Strains | 1985 |
Influence of acute, subchronic and chronic treatment with neuroleptic (haloperidol) on enkephalins and their precursors in the striatum of rat brain.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Haloperidol; Protein Precursors; Rats | 1985 |
A study of intracerebroventricular self-administration of leucine or methionine enkephalin by rats in response to intermittent electric shocks.
Topics: Animals; Electroshock; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Nociceptors; Rats; Rats, Inbred Strains; Reaction Time; Self Administration; Sensory Thresholds | 1985 |
Effects of intracerebral morphine and enkephalins on the caudate-EEG spindle burst.
Topics: Animals; Brain; Caudate Nucleus; Electric Stimulation; Electroencephalography; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Injections; Injections, Intravenous; Male; Microinjections; Morphine; Neurons; Rats; Rats, Inbred Strains | 1985 |
No inotropic action of enkephalins or enkephalin derivatives on electrically-stimulated atria isolated from lean and obese rats.
Topics: Animals; Atrial Function; Carbachol; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Norepinephrine; Obesity; Rats; Rats, Inbred Strains; Rats, Zucker; Stimulation, Chemical | 1985 |
[Synthesis of leucine- and methionine-enkephalin using papain].
Topics: Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Papain | 1985 |
[Changes in the opioid peptide content of the adrenals of rats during immobilization stress].
Topics: Adrenal Glands; Animals; Catecholamines; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Male; Rats; Reserpine; Restraint, Physical; Stress, Psychological | 1985 |
Selective regulation of carboxypeptidase peptide hormone-processing enzyme during enkephalin biosynthesis in cultured bovine adrenomedullary chromaffin cells.
Topics: Adrenal Medulla; Animals; Carboxypeptidases; Cattle; Cells, Cultured; Chromaffin Granules; Colforsin; Diterpenes; Enkephalin, Methionine; Enkephalins; Kinetics; Peptides; Reserpine | 1985 |
Ontogenesis of proenkephalin products in rat striatum and the inhibitory effects of low-level lead exposure.
Topics: Animals; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Lead Poisoning; Pregnancy; Rats | 1985 |
Reduced mechanical activity of perfused rat heart following morphine or enkephalin peptides administration.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Heart Rate; Isoproterenol; Male; Morphine; Myocardial Contraction; Rats; Rats, Inbred Strains | 1985 |
Asymmetric behavior induced by enkephalinergic agents in the basal ganglia.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains | 1985 |
High-performance liquid chromatographic analysis of pulmonary metabolites of Leu- and Met-enkephalins in isolated perfused rat lung.
Topics: Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Lung; Male; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1985 |
The effect of Met-enkephalin and its analogues on gonadotrophin release in patients with polycystic ovary syndrome.
Topics: Adult; Enkephalin, Methionine; Enkephalins; Female; Gonadotropins, Pituitary; Humans; Pituitary Function Tests; Polycystic Ovary Syndrome | 1985 |
The presence of methionine-enkephalin in plasma and urine in normal human subjects and various patients.
Topics: Addison Disease; Cross Reactions; Cushing Syndrome; Enkephalin, Leucine; Enkephalin, Methionine; Glomerulonephritis; Humans; Hypotension; Pheochromocytoma; Radioimmunoassay | 1985 |
Determination of p-hydroxybestatin in human serum by high-performance liquid chromatography using fluorescence detection.
Topics: Chemical Phenomena; Chemistry; Child; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Leucine; Muscular Dystrophies; Spectrometry, Fluorescence; Temperature | 1985 |
Studies on peptides. CXXXI. Synthesis of adrenorphin and enkephalin analogs.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Enkephalin, Methionine; Enkephalins; Male; Mice; Naloxone | 1985 |
Characterization and immunocytochemical application of monoclonal antibodies against enkephalins.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; beta-Endorphin; Brain Chemistry; Brain Stem; Cross Reactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Radioimmunoassay; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1984 |
Sites and mechanisms of actions of enkephalin in the feline parasympathetic ganglion.
Topics: Acetylcholine; Action Potentials; Animals; Cats; Electric Conductivity; Enkephalin, Leucine; Enkephalin, Methionine; Female; Ganglia, Parasympathetic; In Vitro Techniques; Male; Membrane Potentials; Neurons; Synapses; Synaptic Transmission; Time Factors | 1984 |
The isolation of a peptidyl dipeptidase from mouse brain cytosol that cleaves adrenocorticotropic hormone-(7-10) and des-tyrosine-enkephalins.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Brain; Chromatography, High Pressure Liquid; Cytosol; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Kinetics; Mice; Mice, Inbred BALB C; Peptide Fragments; Protease Inhibitors; Structure-Activity Relationship; Substrate Specificity | 1984 |
Neuronal sensitivity to opiate and opioid peptides in the bed nucleus of the stria terminalis. Effects of chronic treatment with morphine.
Topics: Amygdala; Animals; Dihydromorphine; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Evoked Potentials; Guinea Pigs; Hypothalamus, Middle; Male; Morphine; Neural Pathways; Neurons; Norepinephrine; Receptors, Opioid; Synaptic Transmission | 1984 |
Release of opioid peptides in canine hemorrhagic hypotension: effects of naloxone.
Topics: Adrenal Glands; Animals; beta-Endorphin; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hemorrhage; Hypotension; Male; Naloxone | 1984 |
Lack of response in the release of oxytocin and vasopressin from isolated neurohypophyses to dopamine, met-enkephalin and leu-enkephalin.
Topics: Animals; Arginine Vasopressin; beta-Endorphin; Dopamine; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Ouabain; Oxytocin; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains | 1984 |
Opioid control of the ruminant stomach motility: functional importance of mu, kappa and delta receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep; Stomach | 1984 |
Inhibition of the cardiac response to sympathetic nerve stimulation by opioid peptides and its potentiation by morphine and methadone.
Topics: Animals; beta-Endorphin; Drug Synergism; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Guinea Pigs; Heart; In Vitro Techniques; Male; Methadone; Morphine; Myocardial Contraction; Norepinephrine; Sympathetic Nervous System | 1984 |
Enkephalin/catecholamine interactions in cardiac, skeletal, and intestinal muscle.
Topics: Animals; Arousal; Autonomic Nervous System; Blood Pressure; Brain; Catecholamines; Enkephalin, Methionine; Enkephalins; Heart; Humans; Intestines; Muscle, Smooth; Muscles; Myocardial Contraction; Nociceptors; Receptors, Opioid | 1984 |
Role of opiate receptors in regulation of enkephalin stimulation of active sodium and chloride absorption.
Topics: Absorption; Animals; Biological Transport, Active; Brain; Chlorides; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Insulin; Male; Rabbits; Rats; Receptors, Opioid; Sodium; Tetrodotoxin; Vasoactive Intestinal Peptide | 1984 |
[The role of multiple opioid receptors and their ligands in pain modulation].
Topics: Animals; Brain; Chronic Disease; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Pain; Receptors, Opioid; Spinal Cord | 1984 |
[Opioid peptide content of the brain and blood of rats under immobilization stress].
Topics: Animals; beta-Endorphin; Brain Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Recurrence; Restraint, Physical; Stress, Physiological; Time Factors | 1984 |
[Differences in the action of enkephalins, beta-endorphin, and morphine on spontaneous rhythmic movements of the isolated rabbit ileum].
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Gastrointestinal Motility; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Rabbits; Receptors, Opioid | 1984 |
Inhibition via opioid mu- and delta-receptors of vagal transmission in rabbit isolated heart.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; In Vitro Techniques; Male; Morphine; Naloxone; Parasympathetic Nervous System; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptic Transmission; Vagus Nerve | 1984 |
[Endogenous opioid peptide level of patients with borderline arterial hypertension].
Topics: Adolescent; Adult; beta-Endorphin; Blood Pressure; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Hypertension; Male; Physical Exertion; Veins | 1984 |
Kappa 3: a novel subtype of the kappa opioid site in bovine adrenal medulla, highly selective for Met-enkephalin-Arg6-Phe7.
Topics: Adrenal Medulla; Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; In Vitro Techniques; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Opiate peptide receptors on intact NIE-115 neuroblastoma: radioligand binding properties, intracellular response, and effects of increasing membrane cholesterol.
Topics: Animals; Cholesterol; Clone Cells; Enkephalin, Leucine; Enkephalin, Methionine; Membrane Lipids; Mice; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1984 |
Pharmacological evidence that central alpha 2-adrenoceptors are involved in cardiovascular responses to intravenously injected enkephalins in anesthetized dogs.
Topics: Anesthesia, General; Animals; Blood Pressure; Brain Stem; Cardiovascular System; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Heart Rate; Injections; Injections, Intravenous; Prazosin; Receptors, Adrenergic, alpha; Yohimbine | 1984 |
Met-enkephalin inhibition of K+-induced LHRH and ARIF release from rat mediobasal hypothalamic slices.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Potassium; Rats; Somatostatin | 1980 |
K+-evoked release of met-enkephalin from rat striatum in vitro: effect of putative neurotransmitters and morphine.
Topics: Animals; Corpus Striatum; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Haloperidol; Hydroxydopamines; Male; Morphine; Naloxone; Neurotransmitter Agents; Potassium; Radioimmunoassay; Rats | 1980 |
Actions of methionine enkephalin and morphine on single neuronal activity in Helix pomatia l.
Topics: Animals; Dopamine; Dopamine Antagonists; Endorphins; Enkephalin, Methionine; Enkephalins; Helix, Snails; Morphine; Naloxone; Neurons; Receptors, Opioid | 1980 |
Increased beta-endorphin but not met-enkephalin levels in human cerebrospinal fluid after acupuncture for recurrent pain.
Topics: Acupuncture Therapy; Adult; Aged; beta-Endorphin; Chromatography, Ion Exchange; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Male; Middle Aged; Pain Management; Radioimmunoassay; Recurrence | 1980 |
Increase of plasma ACTH in the rat following the administration of D-met2-pro5-enkephalinamide.
Topics: Adrenocorticotropic Hormone; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intravenous; Male; Neurotransmitter Agents; Radioimmunoassay; Rats; Stimulation, Chemical | 1980 |
Neonatal administration of Met-enkephalin facilitates maze performance of adult rats.
Topics: Animals; Animals, Newborn; Brain Chemistry; Delta Sleep-Inducing Peptide; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Learning; Male; MSH Release-Inhibiting Hormone; Oligopeptides; Rats | 1980 |
[Effects of endogenous peptides administered intracerebroventricularly on acetic acid-induced writhing syndrome in mice. I. Neurotensin, bradykinin, somatostatin and methionine-enkephalin].
Topics: Acetates; Animals; Bradykinin; Enkephalin, Methionine; Enkephalins; Mice; Neurotensin; Peptides; Seizures; Somatostatin | 1980 |
Effects of beta-endorphin, met-enkephalin and somatostatin on the neurotensin-induced neurogenic contraction in the guinea-pig ileum.
Topics: Animals; Atropine; beta-Endorphin; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Neurotensin; Somatostatin | 1981 |
Immunohistochemical localisation of substances reactive to antisera against alpha- and beta-endorphin and met-enkephalin in the brain of Rana temporaria L.
Topics: alpha-Endorphin; Animals; beta-Endorphin; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Paraventricular Hypothalamic Nucleus; Pituitary Gland, Anterior; Preoptic Area; Rana temporaria; Tuber Cinereum | 1981 |
An opiate system in the goldfish retina.
Topics: Action Potentials; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Goldfish; Neural Pathways; Neurotransmitter Agents; Retina | 1981 |
Comparative immunocytochemical localization of enkephalin and somatostatin in the median eminence, hypothalamus and adjacent areas of the guinea-pig brain.
Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Guinea Pigs; Hypothalamo-Hypophyseal System; Hypothalamus; Immunoenzyme Techniques; Male; Median Eminence; Somatostatin; Tissue Distribution | 1981 |
The in vitro pharmacology of D-Met2,Pro5-enkephalinamide.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotics; Nictitating Membrane; Rats; Receptors, Opioid; Vas Deferens | 1981 |
Enkephalin/endorphin-related peptides in antropyloric gastrin cells.
Topics: alpha-Endorphin; Animals; Cholecystokinin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrins; Guinea Pigs; Histocytochemistry; Humans; Immunoenzyme Techniques; Pyloric Antrum; Rats; Rats, Inbred Strains; Swine | 1981 |
Hypothalamic substances in the control of body temperature: general characteristics.
Topics: Adrenocorticotropic Hormone; Amino Acids; Animals; beta-Endorphin; Body Temperature Regulation; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Histamine; Humans; Hypothalamus; Melanocyte-Stimulating Hormones; Neurotransmitter Agents; Peptides; Receptors, Opioid; Taurine | 1981 |
The preference of putative pro-enkephalins for different types of opiate receptors.
Topics: Animals; Benzomorphans; Brain; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Morphine; Protein Precursors; Rats; Receptors, Opioid; Vas Deferens | 1981 |
Stimulation by thyrotropin-releasing hormone of vagal outflow to the thyroid gland.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Laryngeal Nerves; Male; Neurotensin; Rats; Rats, Inbred Strains; Somatostatin; Thyroid Gland; Thyrotropin-Releasing Hormone; Triiodothyronine | 1982 |
On the etiopathogenesis of migraine: a possible link between the amines and endorphin hypotheses.
Topics: Adult; Clonidine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Histamine; Humans; Male; Middle Aged; Migraine Disorders; Neurotransmitter Agents; Norepinephrine; Pain; Premedication; Prolactin; Sensory Thresholds; Serotonin; Substance Withdrawal Syndrome | 1982 |
Effects of neuroleptic drugs on endogenous opioid peptides in the rat.
Topics: Animals; Antipsychotic Agents; beta-Endorphin; Brain; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Haloperidol; Pituitary Gland; Rats; Receptors, Dopamine; Receptors, Opioid; Synaptic Transmission | 1981 |
Opiate peptides modulate somatostatin release from dispersed hypothalamic cells.
Topics: Animals; beta-Endorphin; Cold Temperature; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamus; In Vitro Techniques; Male; Naloxone; Rats; Rats, Inbred Strains; Somatostatin | 1981 |
Cholinergic and peptidergic receptors on isolated human antral smooth muscle cells.
Topics: Cholecystokinin; Enkephalin, Methionine; Enkephalins; Humans; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Peptide Fragments; Pyloric Antrum; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, Muscarinic; Sincalide; Vasoactive Intestinal Peptide | 1982 |
Immunoreactive neuropeptide systems in avian embryos (domestic mallard, domestic fowl, Japanese quail).
Topics: Adrenocorticotropic Hormone; Animals; Birds; Brain; Brain Chemistry; Chick Embryo; Coturnix; Ducks; Endocrine Glands; Enkephalin, Methionine; Enkephalins; Gonadotropin-Releasing Hormone; Hormones; Oxytocin; Somatostatin; Vasotocin | 1982 |
Suppression of ethanol consumption by MET-enkephalin in rats.
Topics: Alcohol Drinking; Animals; Depression, Chemical; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Naltrexone; Rats | 1982 |
Isoelectric point determination of human and camel beta-endorphin, alpha-endorphin and enkephalins.
Topics: alpha-Endorphin; Animals; beta-Endorphin; Camelus; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Pituitary Gland; Rats; Rats, Inbred Strains; Species Specificity | 1982 |
Noradrenergic terminal excitability: effects of opioids.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Locus Coeruleus; Male; Morphine; Naloxone; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1982 |
Morphine and [D-Met2,Pro5]enkephalinamide do not show specific neuroleptic activity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Conditioning, Classical; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Haloperidol; Humans; Male; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior | 1982 |
Evidence for the presence of enkephalin in catecholaminergic neurones of cat locus coeruleus.
Topics: Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Locus Coeruleus; Norepinephrine; Tyrosine 3-Monooxygenase | 1982 |
Ethanol, salsolinol and tetrahydropapaveroline alter the discharge of neurons in several brain regions: comparison to opioid effects.
Topics: Animals; Brain; Electric Conductivity; Enkephalin, Methionine; Enkephalins; Ethanol; Glutamates; Glutamic Acid; Hippocampus; Isoquinolines; Male; Naloxone; Narcotics; Neurons; Organ Specificity; Papaverine; Rats; Rats, Inbred Strains; Salsoline Alkaloids; Tetrahydropapaveroline | 1982 |
Inhibition by enkephalins of peristaltic activity of the rabbit ileum and its reversal by naloxone.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Ileum; In Vitro Techniques; Male; Naloxone; Peristalsis; Rabbits | 1982 |
Characterization of electrophoretically separable endorphins in human CSF.
Topics: beta-Endorphin; Chromatography, High Pressure Liquid; Dynorphins; Electrophoresis, Agar Gel; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Radioimmunoassay | 1983 |
Co-localization of vasoactive intestinal peptide (VIP) and enkephalins in chromaffin cells of the adrenal gland of amphibia. Stimulation of corticosteroid production by VIP.
Topics: Acetylcholine; Adrenal Glands; Aldosterone; Animals; Chromaffin System; Corticosterone; Enkephalin, Leucine; Enkephalin, Methionine; Gastrointestinal Hormones; Male; Rana ridibunda; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1983 |
Opiate analgesics and endorphins inhibit rat dorsal root potential in vitro.
Topics: alpha-Endorphin; Analgesics, Opioid; Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Rats; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1980 |
Differential modification of opiate receptor activity by arylsulfatase treatment.
Topics: Analgesia; Analgesics, Opioid; Animals; Arylsulfatases; beta-Endorphin; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Antagonism; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hormones; Kinetics; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Sulfatases | 1983 |
Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Morphine; Naloxone; Somatostatin | 1983 |
Modulatory interactions between enkephalin and catecholamines: anatomical and physiological substrates.
Topics: Animals; Antipsychotic Agents; Brain; Catecholamines; Drug Interactions; Electrophysiology; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Histocytochemistry; Neurons; Rats; Tissue Distribution; Tyrosine 3-Monooxygenase | 1983 |
Selective inhibition of synaptosomal proline uptake by leucine and methionine enkephalins.
Topics: Animals; Aspartic Acid; Biological Transport; Cerebral Cortex; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Neurotransmitter Agents; Proline; Rats; Rats, Inbred Strains; Synaptosomes; Taurine | 1983 |
Plasma immunoreactive beta-endorphin and enkephalin concentration in healthy subjects before and after electroacupuncture.
Topics: Acupuncture Therapy; Adrenocorticotropic Hormone; Adult; beta-Endorphin; Electric Stimulation Therapy; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Naloxone; Radioimmunoassay | 1983 |
In vitro study of frog (Rana ridibunda Pallas) neurointermediate lobe secretion by use of a simplified perifusion system. III. Effect of neuropeptides on alpha-MSH secretion.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Male; Melanocyte-Stimulating Hormones; Morphine; Perfusion; Pituitary Gland; Rana ridibunda; Somatostatin; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 1983 |
The effect of a single temazepam administration on enkephalin content in the striatum and hypothalamus of the rat.
Topics: Animals; Anti-Anxiety Agents; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamus; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Temazepam; Time Factors | 1983 |
Immunochemical evidence for met-enkephalin-like and leu-enkephalin-like peptides in tissues of the earthworm, Lumbricus terrestris.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Male; Oligochaeta; Peptides; Tissue Distribution | 1984 |
Coexistence of substances related to enkephalin and somatostatin in granules of the guinea-pig median eminence: demonstration by use of colloidal gold immunocytochemical methods.
Topics: Animals; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Immunoenzyme Techniques; Median Eminence; Somatostatin | 1984 |
Opiates stimulate low Km GTPase in brain.
Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; GTP Phosphohydrolases; Guanosine Triphosphate; Male; Naloxone; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Characterization of enkephalins and related peptides in rat hypophysial portal blood.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Peptide Fragments; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains | 1984 |
Subcellular distribution of opioid peptides in rat hypothalamus and pituitary.
Topics: Animals; Arginine Vasopressin; Centrifugation, Density Gradient; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Male; Peptide Fragments; Pituitary Gland; Protein Precursors; Rats; Rats, Inbred Strains; Subcellular Fractions; Synaptic Vesicles; Synaptosomes | 1984 |
Primate model of Parkinson's disease: alterations in multiple opioid systems in the basal ganglia.
Topics: Animals; Basal Ganglia; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Macaca mulatta; Male; Nucleus Accumbens; Parkinson Disease; Protein Precursors; Substantia Nigra | 1984 |
Affinities of some common opioid analgesics towards four binding sites in mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding Sites; Brain; Codeine; Cyclazocine; Dextropropoxyphene; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Methionine; Ethylketocyclazocine; In Vitro Techniques; Membranes; Methadone; Mice; Models, Biological; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Tail-pinch method in vitro and the effects of some antinociceptive compounds.
Topics: Analgesics; Animals; Animals, Newborn; Baclofen; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Stereotyped Behavior; Tail | 1984 |
Stereospecificity of opiate-stimulated GTPase activity in brain.
Topics: Animals; Brain; Dextrorphan; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Etorphine; GTP Phosphohydrolases; In Vitro Techniques; Levorphanol; Narcotics; Phosphoric Monoester Hydrolases; Rats; Receptors, Opioid; Stereoisomerism | 1984 |
[Inhibitory effects of dynorphin on electric field stimulation induced contraction of blood vessels in vitro].
Topics: Animals; Dogs; Dynorphins; Ear; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; In Vitro Techniques; Mesenteric Arteries; Naloxone; Rabbits; Receptors, Opioid; Vasoconstriction | 1984 |
Immunohistochemical studies of peptidergic neurons in the dorsal horn of the spinal cord.
Topics: Animals; Colchicine; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Histocytochemistry; Male; Neurons; Neurotensin; Oxytocin; Peptides; Rats; Somatostatin; Spinal Cord; Substance P | 1980 |
Recurrent convulsions and hippocampal [Met5]-enkephalin content.
Topics: Animals; Electroshock; Endorphins; Enkephalin, Methionine; Enkephalins; Hippocampus; Injections; Kainic Acid; Male; Neurons; Rats; Recurrence; Seizures; Substance P; Time Factors | 1980 |
Substance P, morphine and methionine-enkephalin: effects on spontaneous and evoked neuronal firing in the nucleus reticularis gigantocellularis of the rat.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Medulla Oblongata; Morphine; Neurotransmitter Agents; Pain; Pressure; Rats; Substance P | 1980 |
Immunocytochemical demonstration of the catecholamine-synthesizing enzymes and neuropeptides in the catecholamine-storing cells of human fetal sympathetic nervous system.
Topics: Catecholamines; Dopamine beta-Hydroxylase; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Histocytochemistry; Humans; Phenylethanolamine N-Methyltransferase; Pregnancy; Substance P; Sympathetic Nervous System; Tyrosine 3-Monooxygenase | 1980 |
Effect of intraventricular injection of neurotensin and other various bioactive peptides on plasma immunoreactive somatostatin levels in rat hypophysial portal blood.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Kinetics; Male; Neurotensin; Pituitary Gland; Rats; Somatostatin; Substance P | 1981 |
Failure of peptides (angiotensin, bradykinin, substance P, physalaemin, Met-enkephalin) to influence the cardiac action potential.
Topics: Action Potentials; Angiotensin II; Animals; Bradykinin; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Heart; Male; Papillary Muscles; Peptides; Physalaemin; Substance P | 1980 |
[Distribution of substance P and methionine enkephalin in dorsolateral pontine tegmentum of the cat. Immunofluorescence study].
Topics: Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Locus Coeruleus; Neurons; Pons; Substance P; Tissue Distribution | 1981 |
The effect of captopril and ascorbic acid on nonenzymatic methionine enkephalin inactivation in the guinea-pig ileum.
Topics: Animals; Ascorbic Acid; Captopril; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Proline; Puromycin; Sodium Hypochlorite; Teprotide | 1981 |
Immunohistochemical localization of substance-P, somatostatin, and methionine-enkephalin in the spinal cord and dorsal root ganglia of the North American opossum, Didelphis virginiana.
Topics: Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Ganglia, Spinal; Humans; Opossums; Somatostatin; Species Specificity; Spinal Cord; Substance P | 1981 |
Human spinal neurons: innervation by both substance P and enkephalin.
Topics: Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Humans; Male; Neurons; Spinal Cord; Substance P | 1981 |
Effects of beta-endorphin, vasoactive intestinal polypeptide and cholecystokinin octapeptide on cat carotid chemoreceptor activity.
Topics: Animals; beta-Endorphin; Carotid Body; Cats; Cholecystokinin; Endorphins; Enkephalin, Methionine; Enkephalins; Gastrointestinal Hormones; Naloxone; Sincalide; Substance P; Vasoactive Intestinal Peptide | 1981 |
Neurochemical studies in the hypoxic brain: substance P, met-enkephalin, GABA and angiotensin converting enzyme.
Topics: Animals; Brain; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Hypoxia; Male; Organ Size; Peptidyl-Dipeptidase A; Rats; Substance P | 1981 |
Correlation between Met-enkephalin and substance P immunoreactivity in the primate globus pallidus.
Topics: Animals; Chlorocebus aethiops; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Globus Pallidus; Immune Sera; Macaca mulatta; Organ Specificity; Substance P | 1981 |
The distribution of nine peptides in rat spinal cord with special emphasis on the substantia gelatinosa and on the area around the central canal (lamina X).
Topics: Adrenocorticotropic Hormone; Animals; Cholecystokinin; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Male; Nerve Fibers; Nerve Tissue Proteins; Neural Pathways; Neurons; Neurophysins; Oxytocin; Peptides; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Substantia Gelatinosa | 1981 |
Neonatal rat spinal cord slice preparation: postsynaptic effects of neuropeptides on dorsal horn neurons.
Topics: Angiotensin II; Animals; Animals, Newborn; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Neurons; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Substance P | 1981 |
Contractile effect of morphine and related opioid alkaloids, beta-endorphin and methionine enkephalin on the isolated colon from Long Evans rats.
Topics: Animals; beta-Endorphin; Calcium; Colon; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Hexamethonium Compounds; Histamine Release; Humans; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Narcotics; Opioid-Related Disorders; Rats; Rats, Inbred Strains; Tetrodotoxin | 1981 |
Extinction of hippocampal theta rhythm evoked by mid-brain stimulation after intracerebroventricular administration of substance P fragment and enkephalin administration in rabbits.
Topics: Animals; Electric Conductivity; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hippocampus; Kinetics; Mesencephalon; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Substance P; Theta Rhythm | 1981 |
Substance P-, met-enkephalin- and somatostatin-like immunoreactivity distribution in the frog spinal cord.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Immunoenzyme Techniques; Radioimmunoassay; Rana esculenta; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission | 1981 |
Peptides influence retinal ganglion cells.
Topics: Amphibians; Animals; Enkephalin, Methionine; Enkephalins; Iontophoresis; Neurons; Neurotensin; Peptide Fragments; Peptides; Photic Stimulation; Retina; Substance P | 1981 |
Monosodium glutamate exposure in the neonate alters hypothalamic and pituitary neuropeptide levels in the adult.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Glutamates; Hypothalamus; Male; Nerve Tissue Proteins; Neurotensin; Pituitary Gland; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Sex Factors; Sodium Glutamate; Substance P | 1981 |
Rapid separation of enkephalins and endorphins on Sep-Pak reverse phase cartridges.
Topics: alpha-Endorphin; beta-Endorphin; Chromatography; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; gamma-Endorphin | 1981 |
Effects of neurotensin, substance P and methionine-enkephalin on colonic motility.
Topics: Animals; Blood Pressure; Cats; Colon; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Injections, Intravenous; Male; Neurotensin; Substance P | 1981 |
Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cord.
Topics: Afferent Pathways; Animals; Autoradiography; Axonal Transport; Dendrites; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Immunoenzyme Techniques; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Neurotensin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Neurotensin; Receptors, Opioid; Spinal Cord | 1981 |
[Comparative action of met-enkephalin and gamma-endorphin on the neuronal reactions of the rabbit dorsomedial hypothalamus to electrocutaneous and acupuncture stimulation].
Topics: Acupuncture Therapy; Animals; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Endorphin; Hypothalamus; Hypothalamus, Middle; Neurons; Nociceptors; Rabbits; Skin Physiological Phenomena | 1981 |
Abnormalities of the colonic regulatory peptides in Hirschsprung's disease.
Topics: Bombesin; Child, Preschool; Colon; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Glucagon-Like Peptides; Humans; Infant; Megacolon; Neurotensin; Peptides; Radioimmunoassay; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1981 |
Age-related changes in central nervous system enkephalins and substance P.
Topics: Aging; Animals; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Rats; Rats, Inbred Strains; Substance P | 1981 |
Regional distribution of alpha- and gamma-type endorphins in rat brain.
Topics: alpha-Endorphin; Animals; beta-Endorphin; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Endorphin; Male; Rats; Tissue Distribution | 1982 |
Ultrastructural immunocytochemical localization of enkephalin in the goldfish preoptic nucleus.
Topics: Animals; Axonal Transport; Cytoplasm; Cytoplasmic Granules; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Goldfish; Hypothalamus; Male; Neurons; Preoptic Area; Synaptic Vesicles | 1981 |
The actions of neuropeptides on dorsal horn neurons in the rat spinal cord slice preparation: an intracellular study.
Topics: Animals; Electric Conductivity; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Neurons; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Substance P | 1982 |
Localization of methionine-enkephalin, substance P, and somatostatin immunoreactivities in the main olfactory bulb of the hamster.
Topics: Animals; Axonal Transport; Cricetinae; Dendrites; Endorphins; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Male; Mesocricetus; Nerve Fibers; Neurons; Olfactory Bulb; Olfactory Pathways; Somatostatin; Substance P | 1982 |
Evidence for ascending and descending intraspinal as well as primary sensory somatostatin projections in the rat spinal cord.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Substance P | 1982 |
Serotonin and gamma-aminobutyric acid turnover after injection into the median raphe of substance P and D-ala-met-enkephalin amide.
Topics: Animals; Brain Stem; Cyclohexanecarboxylic Acids; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Hippocampus; Hydroxyindoleacetic Acid; Male; Raphe Nuclei; Rats; Serotonin; Substance P | 1982 |
Analgesic activity of substance P in rats: apparent mediation by met-enkephalin release.
Topics: Analgesia; Animals; Bacitracin; beta-Endorphin; Cerebral Ventricles; Endorphins; Enkephalin, Methionine; Enkephalins; Immunologic Techniques; Male; Naloxone; Protease Inhibitors; Rats; Substance P; Vocalization, Animal | 1982 |
Detection and characterisation of neurotransmitters, particularly peptides, in the gastrointestinal tract.
Topics: Angiotensins; Animals; Bombesin; Cholecystokinin; Digestive System; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Hormones; Guinea Pigs; Neurotransmitter Agents; Peptides; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1982 |
Distribution of vasoactive intestinal polypeptide-, substance P-, enkephalin and neurotensin-like immunoreactive nerves in the chicken gut during development.
Topics: Animals; Chick Embryo; Chickens; Digestive System; Endorphins; Enkephalin, Methionine; Enkephalins; Gastrointestinal Hormones; Neurotensin; Peripheral Nerves; Substance P; Vasoactive Intestinal Peptide | 1982 |
Distribution of neuropeptides in the limbic system of the rat: the amygdaloid complex.
Topics: Amygdala; Animals; Brain Mapping; Cholecystokinin; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Male; Neurotensin; Peptides; Rats; Rats, Inbred Strains; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1982 |
Central noradrenergic neurons: identification, distribution and synaptic interactions with axons containing morphine-like peptides.
Topics: Animals; Axonal Transport; Brain; Brain Mapping; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Locus Coeruleus; Medulla Oblongata; Microscopy, Electron; Microscopy, Fluorescence; Neural Pathways; Neurons; Norepinephrine; Synapses; Tyrosine 3-Monooxygenase | 1982 |
Central nervous system immunoreactive somatostatin, substance P and metenkephalin concentrations in experimental hepatic encephalopathy in the rat.
Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Hepatic Encephalopathy; Radioimmunoassay; Rats; Somatostatin; Substance P | 1982 |
The effect of intracerebroventricular infusion of morphine, methionine-enkephalin and D-Ala2-enkephalinamide on body temperature of rabbits.
Topics: Animals; Body Temperature Regulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Fever; Injections, Intraventricular; Male; Morphine; Rabbits; Shivering; Vasoconstriction | 1982 |
Electron immunocytochemical localization of enkephalin-like material in catecholamine-containing cells of the carotid body, the adrenal medulla, and in pheochromocytomas of man and other mammals.
Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Carotid Body; Catecholamines; Cats; Dopamine beta-Hydroxylase; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Humans; Immune Sera; Microscopy, Electron; Pheochromocytoma; Staining and Labeling | 1982 |
The differential distribution and relationship of serotoninergic and peptidergic fibers to sympathoadrenal neurons in the intermediolateral cell column of the rat: a combined retrograde axonal transport and immunofluorescence study.
Topics: Adrenal Medulla; Adrenergic Fibers; Animals; Autonomic Fibers, Preganglionic; Axonal Transport; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Male; Microscopy, Fluorescence; Muridae; Neurons; Peptides; Serotonin; Somatostatin; Spinal Cord; Substance P | 1982 |
The distribution of serotonin, met-enkephalin and beta-lipotropin-like immunoreactivity in neuronal perikarya of the cat brainstem.
Topics: Animals; Axonal Transport; beta-Lipotropin; Brain Mapping; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Neural Pathways; Neurons; Raphe Nuclei; Reticular Formation; Serotonin | 1982 |
Differential effects of D-Ala2 analogues of enkephalins on substance P-induced analgesia in rodents.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Rats; Rats, Inbred Strains; Substance P | 1982 |
Enkephalin- and substance P-like immunoreactivities of mammalian sperm and accessory sex glands.
Topics: Acetylcholine; Animals; beta-Endorphin; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Male; Prostate; Rabbits; Radioimmunoassay; Seminal Vesicles; Species Specificity; Spermatozoa; Substance P | 1982 |
Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks.
Topics: Animals; Brain; Corpus Striatum; DNA; Enkephalin, Methionine; Enkephalins; Haloperidol; Male; Nucleic Acid Hybridization; Plasmids; Poly A; Protein Precursors; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Tissue Distribution | 1983 |
Purification and inhibition by neuropeptides of angiotensin-converting enzyme from rat brain.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Kinetics; Nerve Tissue Proteins; Papain; Peptidyl-Dipeptidase A; Rats; Solubility; Substance P | 1983 |
Induction of differentiation increases Met5-enkephalin and Leu5-enkephalin content in NG108-15 hybrid cells: an immunocytochemical and biochemical analysis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Cell Differentiation; Culture Media; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Methionine; Glioma; Hybrid Cells; Immunochemistry; Neuroblastoma; Staining and Labeling | 1983 |
Presence of somatostatin, enkephalins, and substance P-like peptides in cultured neurons from embryonic chick cerebral hemispheres.
Topics: Animals; Brain; Cells, Cultured; Chick Embryo; Chromatography; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Neurons; Radioimmunoassay; Somatostatin; Substance P | 1983 |
An ion exchange chromatography and radioimmunoassay procedure for measuring opioid peptides and substance P.
Topics: Acetates; Animals; Brain Chemistry; Chromatography, Ion Exchange; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Methanol; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P | 1983 |
[Psychopharmacological study of enkephalins, with special reference to the relation between behavioral profiles and brain monoamines].
Topics: Animals; Biogenic Amines; Brain; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Hydroxyindoleacetic Acid; Male; Mice; Monoamine Oxidase; Motor Activity; Norepinephrine; Serotonin | 1981 |
Intracameral administration of neurotensin induces miosis in the rabbit.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Gonadotropin-Releasing Hormone; Neurotensin; Rabbits; Reflex, Pupillary; Somatostatin; Substance P | 1983 |
Effects of iontophoretically released peptides on primate spinothalamic tract cells.
Topics: Action Potentials; Animals; Cholecystokinin; Drug Interactions; Enkephalin, Leucine; Enkephalin, Methionine; Iontophoresis; Macaca fascicularis; Naloxone; Neurons; Neurotransmitter Agents; Spinothalamic Tracts; Substance P | 1984 |
Distribution of enkephalin, substance P, tyrosine hydroxylase, and 5-hydroxytryptamine immunoreactivity in the septal region of the rat.
Topics: Animals; Axons; Enkephalin, Leucine; Enkephalin, Methionine; Female; Immunoenzyme Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Septum Pellucidum; Serotonin; Substance P; Tyrosine 3-Monooxygenase | 1984 |
Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Sympathetic; Guinea Pigs; Male; Naloxone; Neurotransmitter Agents; Substance P; Synaptic Transmission | 1982 |
Effects of morphine, enkephalins and naloxone on postprandial gastric acid secretion, gastric emptying and gastrin release in dogs.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Food; Gastric Acid; Gastric Emptying; Gastrins; Morphine; Naloxone | 1984 |
An immunocytochemical analysis of methionine enkephalin, substance P, and glutamic acid decarboxylase within neostriatal neurons.
Topics: Afferent Pathways; Animals; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Globus Pallidus; Glutamate Decarboxylase; Male; Neurons; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1984 |
[Effects of 3 anesthetics on enkephalins contents in different brain areas of rats].
Topics: Anesthetics; Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Rats | 1982 |
[Cerebrospinal fluid levels of leucine enkephalin and methionine enkephalin in patients with altered behavior].
Topics: Adult; Aged; Alzheimer Disease; Depressive Disorder; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Huntington Disease; Male; Middle Aged; Neurocognitive Disorders; Schizophrenia, Paranoid | 1984 |
A reduction of the tone of 5-hydroxytryptamine neurons decreases utilization rates of striatal and hypothalamic enkephalins.
Topics: 5,7-Dihydroxytryptamine; Animals; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Fenclonine; Fenfluramine; Hypothalamus; Male; Neurons; Rats; Rats, Inbred Strains; Serotonin | 1984 |
Guanyl nucleotide interactions with opiate receptors in guinea pig brain and ileum.
Topics: Animals; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Ileum; Kinetics; Male; Morphine Derivatives; Organ Specificity; Receptors, Opioid | 1980 |
Effect of antenatal exposure to opiates on the development of opiate receptors in rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Enkephalin, Methionine; Enkephalins; Female; Fetus; Maternal-Fetal Exchange; Morphine; Naloxone; Pregnancy; Rats; Receptors, Opioid | 1980 |
Prolonged hyperprolactinemia influences beta-endorphin and Met-enkephalin in the brain.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Hypothalamus; Neoplasms, Experimental; Pituitary Gland; Pituitary Neoplasms; Prolactin; Rats; Tissue Distribution | 1980 |
Methionine enkephalin and isosteric analogues. Part II.: Receptor conformation of methionine enkephalin.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Protein Conformation; Rats; Receptors, Opioid | 1980 |
Acetaldehyde-enkephalins: pronounced changes in the opiate activity of methionine-enkephalin and leucine-enkephalin on reaction with acetaldehyde.
Topics: Animals; Brain; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Rats; Receptors, Opioid; Vas Deferens | 1980 |
Effect of D-alanine methionine enkephalin amide on ion transport in rabbit ileum.
Topics: Animals; Chlorides; Cyclic AMP; Endorphins; Enkephalin, Methionine; Enkephalins; Epinephrine; Hydroxydopamines; Ileum; In Vitro Techniques; Male; Naloxone; Phentolamine; Rabbits; Sodium | 1980 |
Multiple opiate receptors: [3H]ethylketocyclazocine receptor binding and ketocyclazocine analgesia.
Topics: Analgesics; Animals; Brain; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Mice; Morphine; Motor Activity; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1980 |
Methionine enkephalin inhibits the bursting activity of the Br-type neuron in Helix pomatia L.
Topics: Animals; Electrophysiology; Endorphins; Enkephalin, Methionine; Enkephalins; Helix, Snails; Naloxone; Neurons; Receptors, Opioid | 1980 |
Portentiation of the analgesia induced in rats by morphine or [D-Ala2]-met-enkephalinamide after inhibition of brain type B monoamine oxidase: the role of phenylethylamine.
Topics: Analgesia; Animals; Brain Chemistry; Drug Synergism; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morphine; Phenethylamines; Rats; Reaction Time; Receptors, Opioid | 1980 |
Morphine and opioid peptides reduce paraventricular neuronal activity: studies on the rat hypothalamic slice preparation.
Topics: Animals; beta-Endorphin; Depression, Chemical; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; In Vitro Techniques; Male; Morphine; Naloxone; Neurons; Paraventricular Hypothalamic Nucleus; Rats | 1980 |
Opiate binding sites in the retina: properties and distribution.
Topics: Animals; Binding Sites; Bufo marinus; Cattle; Cell Membrane; Enkephalin, Methionine; Enkephalins; Etorphine; Fishes; Male; Naloxone; Rats; Receptors, Opioid; Retina | 1980 |
Metkephamid, a systemically active analog of methionine enkephalin with potent opioid alpha-receptor activity.
Topics: Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Kinetics; Male; Mice; Rats; Receptors, Opioid; Structure-Activity Relationship; Substance-Related Disorders | 1981 |
Studies of the conformational behaviour and preferential interactions with opiate receptors of the cis and trans forms of [Dmet2,pro5]enkephalin and [Dmet2,pro5]enkephalinamide by 1H and 13C NMR, theoretical calculations and 13C relaxation measurements.
Topics: Carbon Isotopes; Endorphins; Enkephalin, Methionine; Enkephalins; Hydrogen; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Protein Conformation; Receptors, Opioid; Stereoisomerism | 1980 |
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Clone Cells; Diphosphonates; Endorphins; Enkephalin, Methionine; Enkephalins; Glioma; Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Mice; Morphine; Neuroblastoma; Norepinephrine; Rats | 1981 |
Opioid hexapeptides and heptapeptides in adrenal medulla and brain possible implications on the biosynthesis of enkephalins.
Topics: Adrenal Medulla; Amino Acids; Animals; Brain Chemistry; Cattle; Cell Line; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Neuroblastoma; Receptors, Opioid | 1980 |
Met-enkephalin[Arg6,Phe7] interacts with the kappa-receptors on guinea-pig ileum.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Naloxone; Receptors, Opioid | 1980 |
Altered levels of beta-endorphin fragments after chronic morphine treatment of guinea-pig ileum in vitro and in vivo.
Topics: Animals; beta-Endorphin; Chromatography, High Pressure Liquid; Drug Tolerance; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Peptide Fragments; Radioimmunoassay | 1980 |
Stress-induced release of brain and pituitary beta-endorphin: major role of endorphins in generation of hyperthermia, not analgesia.
Topics: Animals; beta-Endorphin; Body Temperature Regulation; Electroshock; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Morphine; Naloxone; Nociceptors; Pituitary Gland; Rats; Stress, Physiological | 1981 |
Mature spinal ganglion cells are not sensitive to opiate receptor mediated actions.
Topics: Action Potentials; Aminopyridines; Animals; Barium; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Ganglia, Spinal; Iontophoresis; Morphine; Morphine Derivatives; Naloxone; Narcotics; Rats; Receptors, Opioid | 1981 |
Behavioral activity of met-enkephalin and ACTH4-10 and other peptides containing a phenylalanine and methionine residue.
Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Peptide Fragments; Peptides, Cyclic; Rats; Structure-Activity Relationship | 1981 |
A study of 24-hour profiles of plasma met-enkephalin in man.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; beta-Lipotropin; Circadian Rhythm; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Hydrocortisone; Male | 1981 |
Development of radioimmunoassayable beta-endorphin and methionine-enkephalin binding sites in regions of rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Binding Sites; Brain; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Radioimmunoassay; Rats; Receptors, Opioid | 1980 |
The interaction of N alpha-alkylenkephalins with opiate receptors. Tissue-dependent shifts in the opiate activity of methionine-enkephalin following N alpha-alkylation.
Topics: Alkylation; Animals; Brain; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Male; Mass Spectrometry; Methods; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Central effects of morphine, levorphanol, (-)-methadone and the opioid-like peptides beta-endorphin and D-alanine2- methionine enkephalinamide on urine volume outflow and electrolytes.
Topics: Animals; beta-Endorphin; Brain; Diuresis; Electrolytes; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Levorphanol; Male; Methadone; Morphine; Naloxone; Narcotics; Rats; Vasopressins | 1981 |
Sex differences in the content of beta-endorphin and enkephalin-like peptides in the pituitary of obese (ob/ob) mice.
Topics: Animals; beta-Endorphin; beta-Lipotropin; Chromatography, Gel; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Mice, Obese; Pituitary Gland; Pituitary Hormones, Anterior; Pro-Opiomelanocortin; Protein Precursors; Radioimmunoassay; Sex Factors | 1981 |
Comparative study on the effect of morphine and the opioid-like peptides in the vas deferens of rodents: species and strain differences, evidence for multiple opiate receptors.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Peptides; Rats; Receptors, Opioid; Species Specificity; Vas Deferens | 1981 |
Opioid activities of beta-casomorphins.
Topics: Animals; Caseins; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Morphine Derivatives; Myenteric Plexus; Rats; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1981 |
Effects of bromocriptine on receptor binding of methionine-enkephalin.
Topics: Animals; Bromocriptine; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Rats; Receptors, Dopamine; Receptors, Opioid | 1981 |
An iontophoretic survey of opioid peptide actions in the rat limbic system: in search of opiate epileptogenic mechanisms.
Topics: Action Potentials; Amygdala; Animals; beta-Endorphin; Endorphins; Enkephalin, Methionine; Enkephalins; Gyrus Cinguli; Hippocampus; Iontophoresis; Limbic System; Male; Morphine; Neurons; Pressure; Rats; Seizures; Septal Nuclei | 1980 |
[Enkephalins and gastrin fragments: possible existence of different analgesic mechanisms].
Topics: Analgesics; Animals; Biogenic Amines; Brain Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Oligopeptides; Pentagastrin; Peptide Fragments; Rats; Receptors, Opioid | 1981 |
GABA and baclofen potentiate the K+-evoked release of methionine-enkephalin from rat striatal slices.
Topics: Analgesia; Animals; Baclofen; Bicuculline; Corpus Striatum; Drug Synergism; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Picrotoxin; Potassium; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1981 |
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons | 1981 |
Ethanol-induced changes of dopaminergic function in three strains of mice characterized by a different population of opiate receptors.
Topics: Animals; Binding, Competitive; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Receptors, Opioid; Species Specificity; Spiperone | 1981 |
A reaction of acetaldehyde with enkephalins and related peptides.
Topics: Acetaldehyde; Animals; beta-Endorphin; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Rats | 1981 |
Acetaldehyde--enkephalins: structure proof and some conformational deductions from one- and two-dimensional proton nuclear magnetic resonance spectra.
Topics: Acetaldehyde; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Magnetic Resonance Spectroscopy; Protein Conformation; Protons | 1981 |
Multiple opiate receptors: phylogenetic differences.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Goldfish; Male; Naloxone; Rats; Receptors, Opioid; Species Specificity; Turtles; Xenopus laevis | 1981 |
(D-Ala2, N-Val5), (D-Ala2, Met5) enkephalins and enkephalinamides. Correlation between biological activity and NMR features.
Topics: Animals; Biological Assay; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Magnetic Resonance Spectroscopy; Male; Mice; Protein Conformation; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1981 |
Structure and biosynthesis of peptides related to corticotrophin and lipotrophin.
Topics: Adrenocorticotropic Hormone; Adult; Animals; beta-Lipotropin; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Peptide Biosynthesis; Pituitary Gland; Pituitary Hormones, Anterior; Pituitary Neoplasms; Pro-Opiomelanocortin; Protein Precursors | 1980 |
Evidence for distinct subcellular sites of opiate receptors. Demonstration of opiate receptors in smooth microsomal fractions isolated from rat brain.
Topics: Animals; Binding, Competitive; Brain; Cell Fractionation; Enkephalin, Methionine; Enkephalins; Guanylyl Imidodiphosphate; Kinetics; Microscopy, Electron; Microsomes; Naloxone; Rats; Receptors, Opioid; Subcellular Fractions | 1981 |
Brain opiates and corticotrophin-related peptides. The Goulstonian Lecture 1980.
Topics: Acupuncture Therapy; Adrenocorticotropic Hormone; beta-Endorphin; beta-Lipotropin; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Melanocyte-Stimulating Hormones; Neoplasms; Radioimmunoassay | 1981 |
Interactions between D-ala-met-enkephalin, A10 dopaminergic neurones, and spontaneous behaviour in the rat.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Exploratory Behavior; Male; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali | 1980 |
Naloxone has a direct effect on the adrenal cortex.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Naloxone; Rats | 1981 |
Glucocorticoids elevate the level of enkephalin-like peptides in neuroblastoma x glioma hybrid cells.
Topics: Alprostadil; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Dexamethasone; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Glucocorticoids; Hybrid Cells; Naloxone; Neuroblastoma; Prostaglandins E | 1981 |
[Sensitivity of neurons in different regions of the brain to met-enkephalin, beta-endorphin, and thyroliberin in the rat].
Topics: Animals; beta-Endorphin; Brain; Cerebral Cortex; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Hippocampus; Male; Nalorphine; Rats; Septum Pellucidum; Thalamus; Thyrotropin-Releasing Hormone | 1981 |
Cyclic AMP, morphine, met-enkephalin and neuronal firing.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Action Potentials; Animals; Cyclic AMP; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mesencephalon; Morphine; Neurons; Pain; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains | 1981 |
Comparison of the anticonvulsant effects of opioid peptides and etorphine in rats after icv administration.
Topics: Animals; Anticonvulsants; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Flurothyl; Male; Morphinans; Naloxone; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1981 |
Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.
Topics: Animals; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Nitrogen Mustard Compounds; Prostaglandins E, Synthetic; Rats; Receptors, Opioid | 1981 |
Plasma norepinephrine, epinephrine and dopamine responses to intracerebral administration of a met-enkephalin analog, D-ala2-met-enkephalinamide, in rats.
Topics: Animals; beta-Endorphin; Cisterna Magna; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Epinephrine; Injections; Injections, Intra-Arterial; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains | 1981 |
High affinity binding of an enkephalin analog in the cerebral ganglion of the insect Leucophaea maderae (Blattaria).
Topics: Animals; Brain; Enkephalin, Methionine; Enkephalins; Female; Ganglia; Insecta; Male; Metamorphosis, Biological; Receptors, Opioid; Sex Factors | 1981 |
Neurons in the frontal cortex of the rat carry multiple opiate receptors.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Frontal Lobe; gamma-Aminobutyric Acid; Male; Morphine; Naloxone; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Detection from rat pituitary of beta-lipotropin and materials containing opiatelike activity by combined enzymatic radioreceptor assay.
Topics: Animals; beta-Endorphin; beta-Lipotropin; Endorphins; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Pituitary Gland; Radioligand Assay; Rats; Time Factors | 1981 |
Effects of opioid peptides on thermoregulation.
Topics: Animals; beta-Endorphin; Body Temperature Regulation; Cats; Cattle; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Naloxone; Naltrexone; Narcotics; Rats; Structure-Activity Relationship | 1981 |
Intracerebroventricular beta-endorphin increases food intake of rats.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Methionine; Enkephalins; Feeding Behavior; Injections, Intraperitoneal; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains | 1981 |
Increase of beta-endorphin in cerebrospinal fluid after removal of ACTH-secreting pituitary adenoma.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; beta-Endorphin; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Hypophysectomy; Male; Middle Aged; Pain, Intractable; Pituitary Neoplasms | 1981 |
A comparison of the ability of opioid peptides and opiates to affect active avoidance conditioning in rats.
Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Diprenorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Narcotics; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Perinatal exposure to delta 9-THC in mice: altered enkephalin and norepinephrine sensitivity in vas deferens.
Topics: Aging; Animals; Dronabinol; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Muscle, Smooth; Norepinephrine; Pregnancy; Prenatal Exposure Delayed Effects; Vas Deferens | 1980 |
Differing distributions of receptors for morphine and Met5-enkephalinamide in the dorsal horn of the cat.
Topics: Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Morphine; Neurons; Nociceptors; Receptors, Opioid; Substantia Gelatinosa | 1981 |
The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease.
Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; Adult; beta-Endorphin; beta-Lipotropin; Cushing Syndrome; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Hormones; Humans; Male; Middle Aged; Naloxone | 1981 |
Studies on circulating met-enkephalin and beta-endorphin: normal subjects and patients with renal and adrenal disease.
Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; beta-Endorphin; beta-Lipotropin; Cushing Syndrome; Dexamethasone; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Hydrocortisone; Insulin; Kidney Failure, Chronic; Male | 1981 |
Beta-endorphin. Vasodilating effect on the microcirculatory system of hamster cheek pouch.
Topics: Animals; beta-Endorphin; Cheek; Cricetinae; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Microcirculation; Morphine; Vasodilation | 1981 |
Classification of multiple morphine and enkephalin binding sites in the central nervous system.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Morphine; Naloxone; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
[Pharmacological data on the existence of opiate receptors in the myocardium of warm-blooded animals].
Topics: Animals; Catecholamines; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Morphine; Myocardial Contraction; Myocardium; Papillary Muscles; Rabbits; Receptors, Opioid | 1981 |
On the presence of met 5-enkephalin receptors on the plasma membrane of Deiters' neurons and their modulation of GABA transport.
Topics: Animals; Biological Transport; Cell Membrane; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Naloxone; Neurons; Rabbits; Receptors, Opioid; Vestibular Nuclei; Vestibular Nucleus, Lateral | 1981 |
A quantitative analysis of the shaking behavior induced in rats by beta-endorphin and [D-Ala2, Met5]enkephalinamide.
Topics: Animals; Behavior, Animal; beta-Endorphin; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Differentiation of agonist conformation and antagonist conformation in multiple opioid receptors.
Topics: Animals; Brain; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Molecular Weight; Naloxone; Protein Conformation; Rats; Receptors, Opioid | 1981 |
Intracerebroventricular administration of nanogram amounts of beta-endorphin and Met-enkephalin causes retrograde amnesia in rats.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Injections, Intraventricular; Rats; Rats, Inbred Strains | 1982 |
Morphine-induced hyperthermia: lack of cross-tolerance with enkephalin analogs.
Topics: Animals; Body Temperature Regulation; Cats; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Morphine; Naloxone; Pentazocine; Receptors, Opioid | 1982 |
Calcium-opiate antagonism in the periaqueductal grey (PGA) region.
Topics: Animals; beta-Endorphin; Calcium; Cerebral Aqueduct; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Morphine; Nociceptors; Rats; Rats, Inbred Strains | 1981 |
Function and regulation of methionine5-enkephalin and its receptors in murine neuroblastoma cells.
Topics: Alprostadil; Animals; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Cyclic AMP; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Mice; Naloxone; Neoplasms, Experimental; Neuroblastoma; Prostaglandins E; Receptors, Opioid | 1982 |
Degradation and oxidation of methionine enkephalin by human neutrophils.
Topics: Azides; Biotransformation; Catalase; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Neutrophils; Oxidation-Reduction; Peroxidase; Superoxide Dismutase; Superoxides; Tyrosine | 1982 |
Evidence that inhibition of nicotine-mediated catecholamine secretion from adrenal chromaffin cells by enkephalin, beta-endorphin, dynorphin (1-13), and opiates is not mediated via specific opiate receptors.
Topics: Adrenal Glands; Animals; beta-Endorphin; Cattle; Chromaffin Granules; Chromaffin System; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kinetics; Morphine; Narcotics; Nicotine; Norepinephrine; Peptide Fragments; Structure-Activity Relationship | 1982 |
Structural requirements for specific recognition of mu or delta opiate receptors.
Topics: Animals; Binding, Competitive; Central Nervous System; Chemical Phenomena; Chemistry, Physical; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Magnetic Resonance Spectroscopy; Molecular Conformation; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 1981 |
Endorphin studies: electrophysiologic effects.
Topics: Animals; beta-Endorphin; Brain; Brain Mapping; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Interneurons; Kindling, Neurologic; Neural Inhibition; Neurons; Pituitary Gland; Rats; Receptors, Opioid; Seizures | 1981 |
Stress and endogenous opioid peptides: a review.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; beta-Endorphin; Body Temperature Regulation; Brain; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Nociceptors; Pituitary Gland; Rats; Receptors, Opioid; Sensory Thresholds; Stress, Physiological | 1981 |
Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy.
Topics: Analgesia; Analgesics; Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mice; Morphine; Naloxone; Peptide Fragments; Receptors, Opioid | 1981 |
Characterization of opiate-mediated responses of the feline ileum and ileocecal sphincter.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Ileocecal Valve; Ileum; Morphine; Muscle, Smooth; Narcotic Antagonists; Receptors, Opioid; Vagus Nerve | 1982 |
Opiate receptor-mediated inhibition of adenylate cyclase in rat striatal plasma membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Membrane; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Guanosine Triphosphate; Kinetics; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Degradation of exogenous enkephalin in the guinea-pig ileum: relative importance of aminopeptidase, enkephalinase and angiotensin converting enzyme activity.
Topics: Aminopeptidases; Angiotensin I; Animals; Bradykinin; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1982 |
Differences in central effects of beta-endorphin and enkephalins: beta-endorphin. A potent psychomotor stimulant.
Topics: Akathisia, Drug-Induced; Animals; beta-Endorphin; Cats; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; Male; Nalorphine; Receptors, Opioid; Vomiting | 1982 |
Elevation of Met5-enkephalin and beta-endorphin hypothalamic content in rats receiving anorectic drugs: differences between D-fenfluramine and D-amphetamine.
Topics: Animals; beta-Endorphin; Body Weight; Brain; Dextroamphetamine; Endorphins; Enkephalin, Methionine; Enkephalins; Fenfluramine; Hypothalamus; Male; Rats; Rats, Inbred Strains; Stimulation, Chemical; Time Factors | 1982 |
beta-Endorphin: demonstration of a tertiary structure in aqueous solution.
Topics: beta-Endorphin; Endorphins; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Peptide Fragments; Protein Conformation; Spectrophotometry, Ultraviolet | 1981 |
Postsynaptic inhibitory effects of Met- and Leu-enkephalin on endocrine and adjacent neurones in the preoptic-septal region of the guinea pig.
Topics: Animals; Brain; Electric Stimulation; Endocrine Glands; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Guinea Pigs; Hypothalamus; Magnesium; Naloxone; Neurons; Preoptic Area; Receptors, Opioid | 1982 |
[Sensitivity of hypothalamic neurons to beta-endomorphin, met-enkephalin, and thyroliberin].
Topics: Animals; beta-Endorphin; Depression, Chemical; Electrophysiology; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Naloxone; Rats; Stimulation, Chemical; Thyrotropin-Releasing Hormone | 1982 |
Evidence against transmitter function of met-enkephalin and chemosynaptic impulse generation in "Merkel cell" mechanoreceptors.
Topics: Afferent Pathways; Animals; Axons; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials, Somatosensory; Mechanoreceptors; Naloxone; Nerve Fibers; Skin; Synapses; Synaptic Transmission | 1982 |
Development of methionine-enkephalin and naloxone binding sites in regions of rat brain.
Topics: Aging; Animals; Binding, Competitive; Brain; Brain Stem; Cerebellum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Tissue Distribution | 1982 |
Pulmonary opiate receptor activation evokes a cardiorespiratory reflex.
Topics: Animals; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hemodynamics; Lung; Male; Myocardial Contraction; Peripheral Nerves; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Respiration; Time Factors | 1982 |
Opiate receptors from different tissue sources: solubilization and characterization.
Topics: Animals; Brain; Cell Line; Cerebral Cortex; Enkephalin, Methionine; Enkephalins; Glioma; Hybridomas; Hypothalamus; Male; Mice; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Solubility; Thalamus | 1982 |
Modulation of peripheral adrenergic neurotransmission by methionine-enkephalin.
Topics: Animals; Cats; Dopamine beta-Hydroxylase; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Morphine; Naloxone; Norepinephrine; Peripheral Nerves; Receptors, Opioid; Spleen; Sympathetic Nervous System; Synaptic Transmission | 1982 |
Distribution of radioactivity in the spinal cord after intracerebroventricular and intravenous injection of radiolabeled opioid peptides in mice.
Topics: Analgesics; Animals; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Muscles; Spinal Cord | 1982 |
Hyperactivity versus explosive motor behavior induced by opioids in the rat. Mechanisms elucidated with enkephalin-tyrosine-o-sulfate and morphine congeners.
Topics: Animals; Electroencephalography; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Hyperkinesis; Morphine; Morphine Derivatives; Rats; Receptors, Opioid | 1982 |
Physiological correlates of multiple subtypes of enteric opiate receptor; functional analysis of myenteric delta receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Morphine; Morphine Derivatives; Myenteric Plexus; Receptors, Opioid; Receptors, Opioid, delta | 1982 |
A multiplicity of opiate receptors and enkephalin neuronal systems.
Topics: Animals; Binding, Competitive; Brain; Brain Mapping; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Naloxone; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1982 |
Neuroblastoma X glioma hybrid cells synthesize enkephalin-like opioid peptides.
Topics: Alprostadil; Animals; Cell Line; Cyclic AMP; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Neuroblastoma; Oxidation-Reduction; Prostaglandins E; Rats | 1982 |
Mammalian neuronal actions of FMRFamide and the structurally related opioid Met-enkephalin-Arg6-Phe7.
Topics: Action Potentials; Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; FMRFamide; Male; Medulla Oblongata; Naloxone; Neurons, Efferent; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Peptidergic regulation of stress-induced eating.
Topics: Animals; Appetite Depressants; Atropine; Bombesin; Carbachol; Cholecystokinin; Enkephalin, Methionine; Enkephalins; Feeding Behavior; Haloperidol; Humans; Isoproterenol; Male; Muscimol; Naloxone; Norepinephrine; Peptide Fragments; Peptides; Phentolamine; Quipazine; Rats; Rats, Inbred Strains; Sincalide; Stress, Psychological | 1982 |
[Met5]enkephalin-Arg-Phe ACTS on vascular opiate receptors.
Topics: Animals; Cyclazocine; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Receptors, Opioid | 1982 |
Opioids increase laryngeal resistance and motoneuron activity in the recurrent laryngeal nerve.
Topics: Animals; Biguanides; Chemoreceptor Cells; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Laryngeal Nerves; Larynx; Male; Morphine; Motor Neurons; Rats; Receptors, Opioid; Recurrent Laryngeal Nerve; Reflex | 1982 |
Modulation of dopamine release in rat striatal slices by delta opiate agonists.
Topics: Animals; Corpus Striatum; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Tetrodotoxin | 1982 |
beta-Endorphin inhibits met-enkephalin breakdown by a brain aminopeptidase: structure-activity relationships.
Topics: Aminopeptidases; Animals; beta-Endorphin; Binding Sites; Brain; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Rats; Structure-Activity Relationship | 1982 |
The influence of selective adeno- and neurointermedio-hypophysectomy upon plasma and brain levels of beta-endorphin and their response to stress in rats.
Topics: Animals; beta-Endorphin; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Hypophysectomy; Male; Pituitary Gland; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains | 1982 |
Characterization of the dopamine stimulated adenylate cyclase in the pedal ganglia of Mytilus edulis: interactions with etorphine, beta-endorphin, DALA, and methionine enkephalin.
Topics: Adenylyl Cyclases; Animals; beta-Endorphin; Bivalvia; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Ganglia; Kinetics; Morphinans | 1981 |
Nerve growth factor induces specific enkephalin binding sites in a nerve cell line.
Topics: Animals; beta-Endorphin; Cell Line; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Morphine; Naloxone; Nerve Growth Factors; Pheochromocytoma; Rats; Receptors, Opioid | 1982 |
beta-Endorphin enhances lymphocyte proliferative responses.
Topics: Analgesics; Animals; beta-Endorphin; Concanavalin A; DNA Replication; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Lymphocyte Activation; Lymphocytes; Male; Naloxone; Rats; Rats, Inbred Lew | 1982 |
Analysis of peptides in tissue and plasma. Use of silicic acid extraction and reversed-phase columns for rapid purification prior to radioimmunoassay.
Topics: Animals; beta-Endorphin; Brain Chemistry; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Peptides; Radioimmunoassay; Rats | 1982 |
Hydrolysis of enkephalins by human converting enzyme and localization of the enzyme in neuronal components of the brain.
Topics: Brain; Enkephalin, Methionine; Enkephalins; Humans; Hydrolysis; In Vitro Techniques; Neurons; Peptidyl-Dipeptidase A; Radioimmunoassay | 1982 |
Enkephalin analogue effects in the amygdala central nucleus on conditioned heart rate.
Topics: Amygdala; Animals; Conditioning, Classical; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Heart Rate; Naloxone; Rabbits; Receptors, Opioid | 1982 |
The effects of leucine-enkephalin on the spontaneous motility of the circular muscle of the cat colon.
Topics: Animals; Atropine; Cats; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Phentolamine; Receptors, Opioid; Tetrodotoxin | 1982 |
Localization of enkephalin-like immunoreactivity in the cat carotid and aortic body chemoreceptors.
Topics: Animals; Aortic Bodies; Carotid Body; Cats; Chemoreceptor Cells; Enkephalin, Leucine; Enkephalin, Methionine; Female; Paraganglia, Nonchromaffin; Receptors, Opioid | 1982 |
Effect of morphine, ACTH, epinephrine, Met-, Leu- and des-Tyr-Met-enkephalin on beta-endorphin-like immunoreactivity of rat brain.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Brain Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; Female; Morphine; Rats | 1982 |
Enkephalin increases the efficacy of dopaminergic transmission in Helix pomatia.
Topics: Animals; Dopamine; Enkephalin, Methionine; Enkephalins; Helix, Snails; Synaptic Transmission; Time Factors | 1982 |
Down regulation of enkephalin (delta) receptors. Demonstration in membrane-bound and solubilized receptors.
Topics: Alkaloids; Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Glioma; Hybrid Cells; In Vitro Techniques; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Solubility | 1982 |
[Transport of calcium to synaptosomes and subcellular membrane fractions of the brain: effects of opioid peptides].
Topics: Animals; beta-Endorphin; Biological Transport, Active; Brain; Calcium; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Intracellular Membranes; Kinetics; Male; Microsomes; Mitochondria; Rats; Synaptosomes | 1982 |
Increase in potencies of opioid peptides after peptidase inhibition.
Topics: Animals; beta-Endorphin; Captopril; Dipeptides; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Leucine; Male; Mice; Myenteric Plexus; Protease Inhibitors; Rats; Rats, Inbred Strains; Vas Deferens | 1983 |
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application.
Topics: Acupuncture Therapy; Animals; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Morphine Dependence; Neprilysin; Nociceptors; Pain; Phenylalanine; Protease Inhibitors; Receptors, Opioid | 1982 |
Interaction of naloxone with mu- and delta-opioid agonists on the respiration of rats.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotics; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Time Factors | 1983 |
Peptide and non-peptide opioid-induced hyperthermia in rabbits.
Topics: Animals; beta-Endorphin; Body Temperature; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptides; Phenazocine; Rats | 1983 |
The heptapeptide Met-enkephalin-Arg6, Phe7 is released from rat striatum in vitro by high potassium.
Topics: Animals; Calcium; Corpus Striatum; Culture Techniques; Enkephalin, Leucine; Enkephalin, Methionine; Potassium; Rats; Synaptic Transmission | 1983 |
The enkephalin system in the rat anterior pituitary: regulation by gonadal steroid hormones and psychotropic drugs.
Topics: Animals; Castration; Chlorides; Dihydrotestosterone; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Estradiol; Female; Gonadal Steroid Hormones; Haloperidol; Lithium; Lithium Chloride; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred F344; Sex Factors; Testosterone | 1983 |
Further evidence for an opioid receptor complex.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; In Vitro Techniques; Rats; Receptors, Opioid | 1983 |
Multi-dimensional analyses of behavior in mice treated with morphine, endorphins and [des-tyrosine1]-gamma-endorphin.
Topics: Animals; Behavior, Animal; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Peptide Fragments | 1983 |
Alcohol and central nervous system peptides.
Topics: Alcohol Drinking; Alcoholism; Animals; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Mice; Mice, Inbred C57BL; Rats; Receptors, Opioid; Social Environment | 1983 |
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1983 |
Role of membrane lipids in peptide hormone function: binding of enkephalins to micelles.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Magnetic Resonance Spectroscopy; Membrane Lipids; Micelles; Models, Neurological; Phospholipids; Protein Binding; Receptors, Opioid | 1984 |
Chronic ethanol changes opiate receptor function in rat striatum.
Topics: Animals; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethanol; Etorphine; Male; Rats; Receptors, Opioid | 1984 |
Brain enkephalin receptors in Parkinson's disease.
Topics: Aged; Brain; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Kinetics; Levodopa; Male; Naloxone; Nucleus Accumbens; Parkinson Disease; Receptors, Dopamine; Receptors, Opioid; Substantia Nigra | 1983 |
Measurement of beta-endorphin and enkephalins in biological tissues and fluids.
Topics: Animals; Antigen-Antibody Complex; beta-Endorphin; Brain Chemistry; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Immune Sera; Iodine Radioisotopes; Pituitary Gland; Radioimmunoassay; Radioisotope Dilution Technique; Tritium | 1983 |
The regulation of delta-opiate receptor density on 108CC15 neuroblastoma X glioma hybrid cells.
Topics: Animals; Bucladesine; Cell Differentiation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Hybrid Cells; Mice; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Down regulation of opiate receptors on 108CC15 hybrid cells is inhibited by receptor occupancy.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Beta-endorphin-, leucine enkephalin- and methionine enkephalin-like immunoreactivity in human cerebrospinal fluid. Simultaneous determination and relation to neurological disorders.
Topics: Adolescent; Adult; Aged; beta-Endorphin; Central Nervous System Diseases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Middle Aged | 1984 |
Alterations of plasma opioid activity in human diabetics.
Topics: beta-Endorphin; Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Insulin; Obesity; Radioimmunoassay; Radioligand Assay; Reference Values | 1984 |
Differences in hypothalamo-pituitary-adrenocortical activity in the rat after acute and prolonged treatment with morphine.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Corticotropin-Releasing Hormone; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Morphine Dependence; Naloxone; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Stress, Physiological | 1984 |
Microelectrophoretic administration of naloxone near motoneurones fails to reproduce the effects of systemic naloxone in anaesthetized cats.
Topics: Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hindlimb; Membrane Potentials; Motor Neurons; Muscles; Naloxone; Neural Inhibition; Reflex, Stretch; Spinal Cord; Synaptic Transmission | 1984 |
Neuroimmunomodulation with enkephalins: effects on thymus and spleen weights in mice.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Female; Mice; Organ Size; Receptors, Opioid; Spleen; Thymus Gland | 1984 |
Alternative modes of enkephalin biosynthesis regulation by reserpine and cyclic AMP in cultured chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; Cyclic AMP; Cycloheximide; Enkephalin, Methionine; Enkephalins; Kinetics; Molecular Weight; Nucleic Acid Hybridization; Reserpine; RNA, Messenger; Transcription, Genetic | 1984 |
Immunocytochemical localization of enkephalin in the lateral septum of the guinea-pig brain. A light- and electron-microscopic study.
Topics: Animals; Brain; Brain Chemistry; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Immunoenzyme Techniques; Microscopy, Electron; Nerve Fibers; Synaptic Vesicles | 1983 |
Immunohistochemical evidence that brain enkephalins arise from a precursor similar to adrenal preproenkephalin.
Topics: Adrenal Medulla; Animals; Brain; Enkephalin, Methionine; Enkephalins; Histocytochemistry; Immune Sera; Immunologic Techniques; Protein Precursors; Rats; Rats, Inbred Strains | 1983 |
Co-existence of unrelated peptides in oxytocin and vasopressin terminals of rat neurohypophyses: immunoreactive methionine-enkephalin-, leucine-enkephalin- and cholecystokinin-like substances.
Topics: Animals; Arginine Vasopressin; Cholecystokinin; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Female; Immunoenzyme Techniques; Male; Peptides; Pituitary Gland, Posterior; Radioimmunoassay; Rats; Rats, Brattleboro; Rats, Inbred Strains; Subcellular Fractions | 1983 |
Met-and Leu-enkephalinergic innervation of the lateral septal nucleus.
Topics: Animals; Brain; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; Guinea Pigs; Immune Sera | 1983 |
Coexistence of vasoactive intestinal peptide and enkephalins in the adrenal chromaffin granules of the frog.
Topics: Adrenal Medulla; Animals; Chromaffin Granules; Chromaffin System; Dopamine beta-Hydroxylase; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Hormones; Immunoenzyme Techniques; Male; Microscopy, Electron; Rana ridibunda; Vasoactive Intestinal Peptide | 1983 |
Enkephalins modify granulocyte-endothelial interactions by stimulating prostacyclin production.
Topics: Cell Adhesion; Complement System Proteins; Endothelium; Enkephalin, Methionine; Enkephalins; Epoprostenol; Humans; Neutrophils; Prostaglandins F; Umbilical Veins | 1983 |
Enkephalin systems in diencephalon and brainstem of the rat.
Topics: Animals; Brain Stem; Diencephalon; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Male; Protein Precursors; Rats; Rats, Inbred Strains; Spinal Cord; Tissue Distribution | 1983 |
Purification and characterization of an enkephalin-degrading aminopeptidase from guinea pig serum.
Topics: Animals; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Kinetics; Molecular Weight; Neprilysin; Substrate Specificity | 1984 |
Immunofluorescence with Met-enkephalin and Leu-enkephalin antibodies in the guinea pig cochlea.
Topics: Animals; Auditory Pathways; Cochlea; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; Guinea Pigs; Hair Cells, Auditory; Organ of Corti; Spiral Ganglion | 1984 |
Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum.
Topics: Animals; Caudate Nucleus; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunoenzyme Techniques; Neural Inhibition; Rats; Rats, Inbred Strains | 1984 |
Localization of enkephalin and cholecystokinin immunoreactivities in the perforant path terminal fields of the rat hippocampal formation.
Topics: Animals; Cholecystokinin; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hippocampus; Immunoenzyme Techniques; Male; Nerve Endings; Neural Pathways; Rats; Temporal Lobe | 1984 |
Purification and characterization of two distinct dipeptidyl aminopeptidases in soluble fraction from monkey brain and their action on enkephalins.
Topics: Animals; Brain; Cytosol; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Kinetics; Macaca fascicularis; Substrate Specificity | 1984 |
Inhibitors of an enkephalin degrading membrane-bound metalloendopeptidase: analgesic properties and effects on striatal enkephalin levels.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Analgesics; Animals; Corpus Striatum; Dipeptides; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Membranes; Naloxone; Neprilysin; para-Aminobenzoates; Protease Inhibitors; Radioimmunoassay; Rats; Rats, Inbred Strains | 1984 |
[Met-enkephalin-Arg-Gly-Leu-like immunoreactivity-containing nerve elements in the canine pancreas--an immunohistochemical study].
Topics: Animals; Cytoplasmic Granules; Dogs; Enkephalin, Methionine; Enkephalins; Female; Ganglia; Histocytochemistry; Immunoenzyme Techniques; Male; Microscopy, Electron; Nerve Fibers; Pancreas; Protein Precursors | 1984 |
Immunohistochemical evidence for preproenkephalin A synthesis in human retinoblastoma.
Topics: Cells, Cultured; Enkephalin, Methionine; Enkephalins; Eye Neoplasms; Female; Fluorescent Antibody Technique; Humans; Infant; Microscopy, Fluorescence; Protein Precursors; Retinoblastoma | 1984 |
Disappearance of enkephalins in the isolated perfused rat lung.
Topics: Angiotensin I; Angiotensin II; Animals; Biological Assay; Captopril; Colon; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Indomethacin; Lung; Perfusion; Prostaglandins; Rats; Rats, Inbred Strains; Stomach | 1984 |
Immunohistochemical study on Met-enkephalin-Arg-Gly-Leu-like immunoreactive nerve fibers in the rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Cholinergic Fibers; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Male; Microscopy, Electron; Nerve Fibers; Protein Precursors; Rats | 1984 |
Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kidney; Leucine; Neprilysin; Protease Inhibitors; Rabbits; Rats; Reaction Time; Thiorphan; Tiopronin | 1984 |
Adrenergic mediation of the intestinal antisecretory action of opiates administered into the central nervous system.
Topics: Animals; Blood Pressure; Brain; Cholera Toxin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Injections, Intraventricular; Intestinal Mucosa; Male; Morphine; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Tyramine | 1984 |
Immunohistochemical localization of unique enkephalin sequences contained in preproenkephalin A in the guinea pig cochlea.
Topics: Animals; Cochlea; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Guinea Pigs; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Organ of Corti; Protein Precursors; Spiral Ganglion | 1984 |
Enkephalin-like immunoreactivity in the guinea pig organ of Corti: ultrastructural and lesion studies.
Topics: Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Cochlear Nerve; Efferent Pathways; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fluorescent Antibody Technique; Guinea Pigs; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Immunoenzyme Techniques; Microscopy, Electron; Olivary Nucleus; Organ of Corti | 1984 |
[Effect of ethanol on the enkephalinergic opioid system of the rat brain].
Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethanol; Male; Morphine; Neprilysin; Protein Binding; Rats | 1984 |
Separation of the enkephalins from proteins in an aqueous medium by chromatofocusing.
Topics: Albumins; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Insulin; Isoelectric Focusing; Lactoglobulins; Proteins | 1984 |
Pharmacological analysis of shaking behavior induced by enkephalins, thyrotropin-releasing hormone or serotonin in rats: evidence for different mechanisms.
Topics: Animals; Behavior, Animal; Brain Chemistry; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Thyrotropin-Releasing Hormone | 1983 |
[The enzyme: a new tool in peptide synthesis].
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Methods; Peptide Fragments; Peptide Hydrolases; Peptides | 1983 |
Modulation of circulatory responses to enkephalins by cyclooxygenase inhibitors.
Topics: Animals; Blood Pressure; Cats; Cyclooxygenase Inhibitors; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hemodynamics; Male; Meclofenamic Acid; Prostaglandins; Splanchnic Circulation | 1983 |
[In vitro release of [5Met]- and [5Leu]-enkephalins from the rat brain crude synaptosomal (P2) fraction: Ca2+-dependency of K+-stimulation and effects of various drugs].
Topics: Animals; Brain; Calcimycin; Calcium; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Ions; Male; Potassium; Rats; Stimulation, Chemical; Subcellular Fractions; Synaptosomes; Veratrine | 1983 |
Enkephalin-like immunoreactivity in Drosophila melanogaster.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Drosophila melanogaster; Enkephalin, Methionine; Enkephalins; Nervous System; Radioimmunoassay | 1983 |
[Changes in the cerebral level of enkephalins during ischemia and recirculation in Mongolian gerbils].
Topics: Animals; Brain Chemistry; Brain Ischemia; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Gerbillinae; Male | 1984 |
Theoretical interpretation of extraction (in brain) of peptides including concentration variations.
Topics: Animals; Arginine Vasopressin; beta-Lipotropin; Blood-Brain Barrier; Brain Chemistry; Carnosine; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Glutathione; Humans; Mathematics; Melanocyte-Stimulating Hormones; Methods; Models, Neurological; Nerve Tissue Proteins; Peptide Fragments | 1984 |
[Effects of leucine-enkephalin and methionine-enkephalin on prolactin and gonadotropin secretion and synthesis in vitro].
Topics: Animals; Cells, Cultured; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Follicle Stimulating Hormone; Luteinizing Hormone; Male; Pituitary Gland, Anterior; Prolactin; Rats | 1980 |
Effects of chemical and surgical lesions on levels of chromatographically identified enkephalin-like peptides in rat hippocampus.
Topics: Animals; Brain Mapping; Chromatography, High Pressure Liquid; Colchicine; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hippocampus; Male; Neural Pathways; Radioimmunoassay; Rats; Rats, Inbred Strains | 1984 |
Co-release of enkephalins and precursors with catecholamines from the perfused cat adrenal gland in situ.
Topics: Acetylcholine; Adrenal Glands; Animals; Catecholamines; Cats; Chromatography, Gel; Chromatography, High Pressure Liquid; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Female; Male; Perfusion; Potassium Chloride; Protein Precursors; Splanchnic Nerves | 1984 |
Determination of neuropeptides in discrete regions of the rat brain by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Brain Chemistry; Cholecystokinin; Chromatography, High Pressure Liquid; Electrochemistry; Enkephalin, Leucine; Enkephalin, Methionine; Nerve Tissue Proteins; Oxidation-Reduction; Rats; Tetragastrin | 1984 |
Measurement of enkephalin peptides in canine brain regions, teeth, and cerebrospinal fluid with high-performance liquid chromatography and mass spectrometry.
Topics: Animals; Brain Chemistry; Caudate Nucleus; Chromatography, High Pressure Liquid; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamus; Mass Spectrometry; Microcomputers; Models, Biological; Pituitary Gland; Tooth | 1984 |
Extraction and partial characterization of enkephalin-like peptides from splanchnic nerve.
Topics: Adrenal Medulla; Animals; Carboxypeptidase B; Carboxypeptidases; Chloroform; Chromatography, Gel; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Methanol; Solubility; Splanchnic Nerves; Swine; Trypsin | 1984 |
Demonstration and characterization of immunoreactive methionine-enkephalin, leucine-enkephalin, methionine-enkephalin-Arg6-Gly7-Leu8 and methionine-enkephalin-Arg6-Phe7 in human phaeochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Pheochromocytoma; Radioimmunoassay | 1984 |
[Analysis of enkephalin conformation using circular dichroism and fluorescence spectroscopy].
Topics: Chemical Phenomena; Chemistry; Circular Dichroism; Enkephalin, Leucine; Enkephalin, Methionine; Protein Conformation; Spectrometry, Fluorescence | 1984 |
Evidence for a folded conformation of methionine- and leucine-enkephalin in a membrane environment.
Topics: Dimethyl Sulfoxide; Enkephalin, Leucine; Enkephalin, Methionine; Liposomes; Lysophosphatidylcholines; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation | 1984 |
Enkephalin content in rat striatum during prolonged treatment with fluphenazine.
Topics: Animals; Apomorphine; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fluphenazine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1984 |
Several distinct receptor binding enkephalins in olivocochlear fibers and terminals in the organ of Corti.
Topics: Animals; Chromatography, High Pressure Liquid; Cochlear Nerve; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Olivary Nucleus; Organ of Corti; Radioimmunoassay; Stria Vascularis | 1984 |
Electrochemical measurement of neurohypophyseal peptide levels in rat hypothalamic regions after adrenalectomy.
Topics: Adrenalectomy; Angiotensin II; Animals; Arginine Vasopressin; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamo-Hypophyseal System; Male; Nerve Tissue Proteins; Oxytocin; Rats; Rats, Inbred Strains | 1984 |
Distribution and characterization of synenkephalin immunoreactivity in the bovine brain and pituitary.
Topics: Animals; Brain Chemistry; Cattle; Caudate Nucleus; Chromatography, Gel; Enkephalin, Methionine; Enkephalins; Globus Pallidus; Hypothalamus; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay | 1984 |
Characterization of new enkephalin-containing peptides in the adrenal medulla by immunoblotting.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Cattle; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Immune Sera; Immunoelectrophoresis; Molecular Weight; Protein Precursors; Radioimmunoassay | 1984 |
Processing of proenkephalin is tissue-specific.
Topics: Adrenal Medulla; Animals; Cattle; Enkephalin, Methionine; Enkephalins; Hypothalamus; Organ Specificity; Pituitary Gland, Posterior; Protein Precursors; Supraoptic Nucleus | 1984 |
Analgesic effects of enkephalin analogs in rats.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Enkephalin biosynthesis in adrenal medulla. Modulation of proenkephalin mRNA content of cultured chromaffin cells by 8-bromo-adenosine 3',5'-monophosphate.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Medulla; Animals; Cattle; Cells, Cultured; DNA; Enkephalin, Methionine; Enkephalins; Kinetics; Nucleic Acid Hybridization; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1984 |
Synenkephalin is coreleased with Met-enkephalin from neuronal terminals in vitro.
Topics: Animals; Calcium; Cattle; Enkephalin, Methionine; Enkephalins; Globus Pallidus; In Vitro Techniques; Nerve Endings; Pituitary Gland, Posterior; Potassium; Protein Precursors | 1984 |
Detection of the messenger RNA coding for preproenkephalin A in bovine adrenal by in situ hybridization.
Topics: Adrenal Glands; Adrenal Medulla; Animals; Cattle; Cells, Cultured; DNA; Enkephalin, Methionine; Enkephalins; Histocytochemistry; Norepinephrine; Nucleic Acid Hybridization; Protein Precursors; RNA, Messenger | 1984 |
Proenkephalin, [Met]enkephalin, and oxytocin immunoreactivities are colocalized in bovine hypothalamic magnocellular neurons.
Topics: Animals; Cattle; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Hypothalamus; Immune Sera; Immunoassay; Neurons; Organ Specificity; Oxytocin; Protein Precursors; Supraoptic Nucleus | 1983 |
Isolation and identification of enkephalins in pedal ganglia of Mytilus edulis (Mollusca).
Topics: Animals; Binding Sites; Bivalvia; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia; Protein Binding | 1984 |
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test.
Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
[Opioid peptides in the tooth pulp].
Topics: Animals; Dental Cavity Preparation; Dental Pulp; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Activation; Rats; Trypsin | 1983 |
The inhibitory effect of opioid peptides and morphine applied intrathecally and intracerebroventricularly on the micturition reflex in the cat.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Morphine; Naloxone; Oligopeptides; Reflex; Thiorphan; Tiopronin; Urination | 1984 |
The enkephalinergic neuron: implications of a polyenkephalin precursor.
Topics: Adrenal Medulla; Animals; Brain; Catecholamines; Cattle; Chromaffin Granules; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Neurons; Protein Precursors; Radioimmunoassay | 1983 |
Enkephalins--enhancement of active T-cell rosettes from normal volunteers.
Topics: Adjuvants, Immunologic; Adult; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Immunity, Cellular; Rosette Formation; T-Lymphocytes | 1984 |
Preparation of stable isotope-incorporated peptide internal standards for field desorption mass spectrometry quantification of peptides in biologic tissue.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Enkephalin, Leucine; Enkephalin, Methionine; Kinetics; Mass Spectrometry; Oxygen Isotopes; Peptides; Thalamus | 1983 |
[Effect of neurotropic compounds on the transmembrane potential of synaptosomes].
Topics: Animals; Cerebral Cortex; Chlorpromazine; Colchicine; Cytochalasin B; Diazepam; Enkephalin, Leucine; Enkephalin, Methionine; Haloperidol; Imipramine; Membrane Potentials; Peptides; Psychotropic Drugs; Rats; Synaptosomes; Trifluoperazine; Tuftsin | 1983 |
Chromatographic identification of enkephalins in the guinea pig retina.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Radioimmunoassay; Radioligand Assay; Retina | 1983 |
Colocalization of proenkephalin peptides in rat brain neurons.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Neurons; Protein Precursors; Rats; Rats, Inbred Strains | 1983 |
Multiple molecular forms of enkephalins in the guinea pig hippocampus.
Topics: Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hippocampus; Radioimmunoassay | 1983 |
Enkephalins are associated with adrenergic granules in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Catecholamines; Cattle; Centrifugation; Chromaffin Granules; Chromaffin System; Dopamine beta-Hydroxylase; Enkephalin, Methionine; Enkephalins; Sympathetic Nervous System; Tissue Distribution | 1983 |
Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain.
Topics: Brain; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Parkinson Disease; Reference Values; Tissue Distribution | 1983 |
The stinging response of the honeybee: effects of morphine, naloxone and some opioid peptides.
Topics: Animals; Bees; Behavior, Animal; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Insect Bites and Stings; Morphine; Naloxone | 1983 |
Parallel distribution of methionine-enkephalin-Arg6-Gly7-Leu8 with methionine-enkephalin, leucine-enkephalin and methionine-enkephalin-Arg6-Phe7 in human and bovine brains.
Topics: Animals; Brain Chemistry; Cattle; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Species Specificity | 1983 |
Isolation of molluscan opioid peptides.
Topics: Animals; Bivalvia; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Ganglia | 1983 |
Met-enkephalin-Arg6-Gly7-Leu8 exists together with Met-enkephalin-Arg6-Phe7, Met-enkephalin and Leu-enkephalin in human stomach.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Pyloric Antrum; Radioimmunoassay | 1983 |
Methionine-enkephalin, leucine-enkephalin methionine-enkephalin-Arg6-Phe7 and methionine-enkephalin-Arg6-Gly7-Leu8 in human pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Pheochromocytoma; Radioimmunoassay | 1983 |
[Effect of ethanol on the concentration of enkephalins in the brain of rats with different levels of alcoholic motivation].
Topics: Alcohol Drinking; Alcoholism; Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ethanol; Humans; Injections, Intraperitoneal; Male; Motivation; Rats; Time Factors | 1983 |
Regional distribution of methionine-enkephalin-Arg6-Phe7 in the rat brain: comparative study with the distribution of other opioid peptides.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Pituitary Hormones, Anterior; Pro-Opiomelanocortin; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Tissue Distribution | 1983 |
Regulation of methionine-enkephalin precursor messenger RNA in rat striatum by haloperidol and lithium.
Topics: Animals; Cell-Free System; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Haloperidol; Lithium; Male; Protein Biosynthesis; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger | 1983 |
Neural control of the sphincter of Oddi. Physiologic role of enkephalins on the regulation of basal sphincter of Oddi motor activity in the cat.
Topics: Ampulla of Vater; Animals; Atropine; Autonomic Nerve Block; Cats; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Muscle Contraction; Reserpine; Serotonin; Serotonin Antagonists; Sphincter of Oddi; Tetrodotoxin | 1984 |
Iminoglycine transport system in synaptosomes and its interaction with enkephalins.
Topics: Animals; Biological Transport; Cerebral Cortex; Enkephalin, Leucine; Enkephalin, Methionine; Glycine; Imino Acids; Kinetics; Narcotics; Pipecolic Acids; Proline; Rats; Rats, Inbred Strains; Sodium; Synaptosomes | 1984 |
Prenatal alcohol exposure alters enkephalin levels, without affecting ethanol preference.
Topics: Alcohol Drinking; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ethanol; Female; Fetus; Globus Pallidus; Male; Pituitary Gland; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains | 1984 |
Evidence for an opiate-mediated pyloric sphincter reflex.
Topics: Acid-Base Equilibrium; Animals; Cats; Duodenum; Electromyography; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gastric Emptying; Gastrointestinal Motility; Manometry; Muscle Contraction; Neural Pathways; Pressure; Pylorus; Reflex | 1984 |
Neuroimmunomodulation with enkephalins: enhancement of human natural killer (NK) cell activity in vitro.
Topics: Adult; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Killer Cells, Natural; Male; Middle Aged | 1984 |
Sensitivity to morphine-evoked bradycardia in rats is modified by dynorphin (1-13), Leu- and Met-enkephalin.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Heart Rate; Male; Morphine; Peptide Fragments; Rats; Rats, Inbred Strains | 1984 |
Modification of the cardiovascular response to enkephalin by preoptic-hypothalamic periventricular lesions.
Topics: Animals; Blood Pressure; Enkephalin, Methionine; Enkephalins; Heart Rate; Hemodynamics; Hypothalamus; Injections, Intraventricular; Male; Preoptic Area; Rats; Sodium Chloride | 1984 |
X-ray diffraction studies of enkephalins. Crystal structure of [(4'-bromo) Phe4,Leu5]enkephalin.
Topics: Crystallization; Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen Bonding; Models, Molecular; Protein Conformation; X-Ray Diffraction | 1984 |
Pentylenetetrazol kindling produces a long-lasting elevation of IR-Met-enkephalin but not IR-Leu-enkephalin in rat brain.
Topics: Amygdala; Animals; Brain Chemistry; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Hippocampus; Hypothalamus; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Septum Pellucidum | 1984 |
In vitro interaction of opioid peptides with phospholipids. Formation and characterization of complexes.
Topics: Acylation; Chromatography, Gel; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen-Ion Concentration; In Vitro Techniques; Phosphatidylserines; Phospholipids; Spectrophotometry, Ultraviolet | 1984 |
Opposite effects of Met-enkephalin and Leu-enkephalin on a discriminated shock-escape task.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Escape Reaction; Male; Mice; Motor Activity; Naloxone | 1984 |
Evidence for different patterns of post-translational processing of pro-enkephalin in the bovine adrenal, colon and striatum indicated by radioimmunoassay using region-specific antisera to Met-Enk-Arg6-Phe7 and Met-Enk-Arg6-Gly7-Leu8.
Topics: Adrenal Glands; Animals; Cattle; Colon; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Organ Specificity; Protein Precursors; Radioimmunoassay | 1984 |
Kinetics of chymotrypsin- and papain-catalysed synthesis of [leucine]enkephalin and [methionine]enkephalin.
Topics: Catalysis; Chromatography, High Pressure Liquid; Chymotrypsin; Enkephalin, Leucine; Enkephalin, Methionine; Kinetics; Models, Chemical; Oligopeptides; Papain; Substrate Specificity | 1984 |
Distribution and characterization of opioid peptides derived from proenkephalin A in human and rat central nervous system.
Topics: Adolescent; Adult; Aged; Animals; Brain; Enkephalin, Methionine; Enkephalins; Female; Humans; Male; Middle Aged; Peptides; Pituitary Gland; Protein Precursors; Rats; Rats, Inbred Strains; Spinal Cord | 1984 |
Enkephalin-mediated basal ganglia influences over the optic tectum: immunohistochemistry of the tectum and the lateral spiriform nucleus in pigeon.
Topics: Animals; Basal Ganglia; Columbidae; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; Mesencephalon; Nerve Fibers; Neural Pathways; Neurons; Superior Colliculi | 1982 |
Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors.
Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Enkephalins; Exopeptidases; Female; Leucine; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin | 1982 |
A unique proenkephalin-converting enzyme purified from bovine adrenal chromaffin granules.
Topics: Adrenal Medulla; Animals; Cattle; Chromaffin Granules; Chromaffin System; Chromatography, Gel; Chromatography, High Pressure Liquid; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Metalloendopeptidases; Protein Precursors | 1982 |
Regional distribution of endorphin, Met5-enkephalin and Leu5-enkephalin in the pigeon brain.
Topics: Animals; Brain; Brain Chemistry; Columbidae; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immunoenzyme Techniques; Neurons; Tissue Distribution | 1980 |
Effects of thyrotrophin-releasing hormone, and methionine-enkephalin on gastric acid and pepsin secretion in the cat.
Topics: Animals; Blood Glucose; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Gastric Juice; Insulin; Naloxone; Pentagastrin; Pepsin A; Thyrotropin-Releasing Hormone; Time Factors | 1980 |
D-ala2-methionine-enkephalinamide self-administration in the morphine-dependent rat.
Topics: Animals; Drug Administration Schedule; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Injections, Intraventricular; Morphine Dependence; Rats; Self Administration; Substance Withdrawal Syndrome | 1980 |
Biphasic effects of a potent enkephalin analogue (D-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mice; Morphine; Motor Activity; Time Factors | 1980 |
Inhibitory actions of methionine-enkephalin and morphine on the cat carotid chemoreceptors.
Topics: Acetylcholine; Animals; Carbon Dioxide; Carotid Sinus; Cats; Chemoreceptor Cells; Cyanides; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Morphine; Naloxone | 1980 |
(D-Met2,Pro5)-enkephalinamide-induced blockade of ovulation and its reversal by naloxone in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Estrus; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Naloxone; Ovulation; Pregnancy; Rats | 1981 |
Hippocampal involvement in the pharmacologic induction of withdrawal-like behaviors.
Topics: Animals; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Escape Reaction; Ethylketocyclazocine; Hippocampus; Humans; Injections, Intraventricular; Kainic Acid; Morphine Dependence; Pyrrolidines; Rats; Serotonin; Shivering; Substance Withdrawal Syndrome; Valproic Acid | 1981 |
Characterization of the respiratory activity of (D-Ala2)methionine-enkephalinamide.
Topics: Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Rats; Respiration; Respiratory Center; Time Factors | 1981 |
[Demonstration of neuropeptides in cultured neuroretinal cells of chick embryo].
Topics: Animals; Cells, Cultured; Chick Embryo; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Melanocyte-Stimulating Hormones; Neurons; Retina; Thyrotropin-Releasing Hormone | 1981 |
Effects of naloxone on carotid body chemoreception and ventilation in the cat.
Topics: Animals; Carbon Dioxide; Carotid Body; Cats; Chemoreceptor Cells; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Oxygen; Respiration; Tidal Volume | 1981 |
Endogenous opioid poisoning?
Topics: Aged; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Naloxone; Respiratory Insufficiency | 1982 |
Effect of opioid peptides on gonadotrophin secretion.
Topics: Animals; Castration; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Follicle Stimulating Hormone; Injections, Intraventricular; Luteinizing Hormone; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Analysis of the 2-deoxy-D-glucose-induced vagal stimulation of gastric secretion and gastrin release in dogs using methionine-enkephalin, morphine and naloxone.
Topics: Animals; Bethanechol Compounds; Deoxy Sugars; Deoxyglucose; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Gastric Acid; Gastrins; Male; Morphine; Naloxone; Pepsin A; Stimulation, Chemical; Vagus Nerve | 1982 |
Peptides, the pineal gland and thermoregulation.
Topics: Animals; Body Temperature Regulation; Cyprinidae; Endorphins; Enkephalin, Methionine; Enkephalins; Goldfish; Naloxone; Peptides; Pineal Gland; Thyrotropin-Releasing Hormone | 1982 |
[Demonstration of enkephalins in pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Cells, Cultured; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Nicotine; Pheochromocytoma; Protein Biosynthesis; RNA, Messenger | 1982 |
[Implication of enkephalins in central cardiovascular regulation in the rat].
Topics: Animals; Autonomic Nervous System; Blood Pressure; Diprenorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Heart Rate; Hypertension; Injections, Spinal; Naloxone; Oxygen; Rats; Rats, Inbred Strains; Respiration | 1982 |
Attenuation of CO2-induced retrograde amnesia by enkephalins in 20- and 34-day-old-rats.
Topics: Age Factors; Animals; Avoidance Learning; Carbon Dioxide; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Memory; Mental Recall; Muridae; Retention, Psychology | 1982 |
High-performance liquid chromatographic identification of enkephalin-like peptides in the cochlea.
Topics: Animals; Chromatography, High Pressure Liquid; Cochlea; Enkephalin, Methionine; Enkephalins; Female; Guinea Pigs; Radioimmunoassay | 1983 |
Synthesis and evaluation of 1- and 2-substituted fentanyl analogues for opioid activity.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Morphine; Naloxone; Vas Deferens | 1983 |
Evidence for the presence of enkephalins in the heart.
Topics: Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Male; Myocardium | 1983 |
Telencephalic enkephalinergic systems in the rat brain.
Topics: Animals; Brain; Brain Chemistry; Colchicine; Enkephalin, Leucine; Enkephalin, Methionine; Immunoassay; Male; Neurons; Protein Precursors; Rats; Rats, Inbred Strains; Telencephalon; Tissue Distribution | 1983 |
[Selective reduction by morphine and enkephalins of depolarization induced by application of dopamine to Helix pomatia neurons].
Topics: Acetylcholine; Animals; Dopamine Antagonists; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia; Helix, Snails; In Vitro Techniques; Morphine; Naloxone; Neurons | 1983 |
Occurrence of methionine-enkephalin-Arg6-Gly7-Leu8 with methionine-enkephalin, leucine-enkephalin and methionine-enkephalin-Arg6-Phe7 in human gastric antrum.
Topics: Adult; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Pyloric Antrum; Radioimmunoassay | 1983 |
[Effect of enkephalins on the reactivity of 2 hippocampal synaptic systems].
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Evoked Potentials; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Pyramidal Tracts | 1983 |
Measurement of total opioid peptides in rat brain and pituitary by radioimmunoassay directed at the alpha-N-acetyl derivative.
Topics: Acetylation; Animals; Brain Chemistry; Corpus Striatum; Cross Reactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Pituitary Gland; Radioimmunoassay; Rats; Structure-Activity Relationship | 1983 |
Tolerance to morphine bradycardia in the rat.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains | 1983 |
Prolonged intermittent footshock stress decreases Met and Leu enkephalin levels in brain with concomitant decreases in pain threshold.
Topics: Animals; Body Temperature; Brain; Electroshock; Enkephalin, Leucine; Enkephalin, Methionine; Foot; Latency Period, Psychological; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Stress, Physiological | 1983 |
Enzyme-linked immunosorbent assay for leucine and methionine enkephalins.
Topics: Antibodies; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme-Linked Immunosorbent Assay; Radioimmunoassay | 1983 |
The effect of enkephalins on the acetylcholinesterase activity in rat brain synaptosomes.
Topics: Acetylcholinesterase; Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Rats; Rats, Inbred Strains; Synaptosomes | 1983 |
Brain content of immunoreactive [Leu5]enkephalin and [Met5]enkephalin after pentylenetetrazol-induced convulsions.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Male; Pentylenetetrazole; Radioimmunoassay; Rats; Rats, Inbred Strains; Seizures | 1983 |
Effects of Met-enkephalin and naloxone on gastric emptying and secretion in rhesus monkeys.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gastric Emptying; Gastric Juice; Hydrogen-Ion Concentration; Macaca mulatta; Male; Naloxone | 1983 |
Plasma methionine-enkephalin and leucine-enkephalin in normal subjects and patients with pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Humans; Male; Norepinephrine; Pheochromocytoma | 1983 |
Enkephalin-binding systems in human plasma.
Topics: Amino Acids; Blood Proteins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Protein Binding; Serum Albumin; Tritium | 1983 |
Effects of denervation on the sensitizing effect to noradrenaline induced by morphine in the vas deferens of mice treated chronically with morphine.
Topics: Acetylcholine; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Male; Mice; Morphine; Morphine Dependence; Muscle Contraction; Muscle Denervation; Muscle, Smooth; Norepinephrine; Vas Deferens | 1982 |
Effect of the pre-training administration of beta-endorphin, leucine-, methionine- and [des-Tyr1] methionine-enkephalin on the acquisition and retention of a shuttle avoidance response by rats.
Topics: Amnesia, Retrograde; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Memory; Rats; Rats, Inbred Strains; Retention, Psychology | 1982 |
Radioimmunoassay of methionine(5)-enkephalin sulphoxide: phylogenetic and anatomical distribution.
Topics: Animals; Brain Chemistry; Chickens; Cross Reactions; Endorphins; Enkephalin, Methionine; Enkephalins; Fishes; Helix, Snails; Intestine, Small; Pancreatin; Phylogeny; Pituitary Gland; Radioimmunoassay; Species Specificity; Tissue Distribution; Xenopus | 1980 |
Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7.
Topics: Analgesics; Animals; Diarrhea; Diuresis; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Naloxone; Rats | 1980 |
Cell-free translation and partial characterization of mRNA coding for enkephalin-precursor protein.
Topics: Adrenal Medulla; Animals; Base Sequence; Carboxypeptidase B; Carboxypeptidases; Cattle; Cell-Free System; Endorphins; Enkephalin, Methionine; Enkephalins; Molecular Weight; Protein Biosynthesis; Protein Precursors; RNA, Messenger; Trypsin | 1982 |
Enkephalin biosynthetic pathway: a 5300-dalton adrenal polypeptide that terminates at its COOH end with the sequence [Met]enkephalin-Arg-Gly-Leu-COOH.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cattle; Chromaffin Granules; Chromaffin System; Endorphins; Enkephalin, Methionine; Enkephalins; Peptides; Protein Precursors | 1982 |
Molecular forms of the putative enkephalin precursor BAM-12P in bovine adrenal, pituitary, and hypothalamus.
Topics: Adrenal Cortex; Adrenal Glands; Adrenal Medulla; Animals; Cattle; Cross Reactions; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Pituitary Gland; Protein Precursors; Radioimmunoassay | 1982 |
Effects of met-enkephalin on slow synaptic inhibition in frog sympathetic ganglion.
Topics: Animals; Dopamine; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Ganglia, Sympathetic; In Vitro Techniques; Membrane Potentials; Rana esculenta; Rana temporaria; Synapses | 1980 |
Naloxone blocks the effect of 5-hydroxy-tryptophan on passive avoidance learning in rats: implication of endogenous opiod peptides.
Topics: 5-Hydroxytryptophan; Animals; Avoidance Learning; Behavior, Animal; Clorgyline; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Rats; Serotonin | 1981 |
Dorsal column stimulation in multiple sclerosis: effects on bladder, leg blood flow and peptides.
Topics: Electric Stimulation Therapy; Enkephalin, Methionine; Enkephalins; Humans; Leg; Male; Multiple Sclerosis; Peptides; Pressure; Regional Blood Flow; Spinal Cord; Urethra; Urodynamics | 1981 |
[Effect of met- and leu-enkephalins and their synthetic analog on stimulation and acupunture analgesia].
Topics: Acupuncture Therapy; Analgesia; Animals; Brain Stem; Electric Stimulation Therapy; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Pain; Pain Management; Rats | 1981 |
Inhibition of in situ metabolism of [3H](met5)-enkephalin and potentiation of (met5)-enkephalin analgesia by captopril.
Topics: Animals; Behavior, Animal; Captopril; Corpus Striatum; Drug Synergism; Endorphins; Enkephalin, Methionine; Enkephalins; Proline; Rats | 1980 |
Effect of met-enkephalin on portal insulin and glucose in the rat.
Topics: Animals; Blood Glucose; Endorphins; Enkephalin, Methionine; Enkephalins; Fasting; Insulin; Male; Portal Vein; Rats | 1980 |
Immunohistochemical localization of an opiate peptide.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Mice; Neurons; Spinal Cord | 1980 |
Generation of methionine and leucine-enkephalin from precursor molecules by cation-sensitive neutral endopeptidase of bovine pituitary.
Topics: Animals; Chromatography, High Pressure Liquid; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kinetics; Pituitary Gland; Rabbits; Substrate Specificity | 1980 |
Isolation of human met-enkephalin and two groups of putative precursors (2K-pro-met-enkephalin) from an adrenal medullary tumour.
Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Amino Acids; Chromatography, Gel; Chromatography, High Pressure Liquid; Endopeptidases; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Molecular Weight; Protein Precursors | 1980 |
Effect of enkephalins and morphine on insulin secretion from isolated rat islets.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Morphine; Perfusion; Rats | 1980 |
Localization of (Met5)- and (Leu5)-enkephalin in nerve terminals and SIF cells in adult human sympathetic ganglia.
Topics: Adult; Catecholamines; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Ganglia, Sympathetic; Humans; Nerve Endings | 1980 |
Immunocytochemical demonstration of met-enkephalin in the central nervous system of the domestic fowl.
Topics: Animals; Brain Chemistry; Chickens; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Immunoenzyme Techniques; Male; Nerve Fibers; Peripheral Nerves; Spinal Cord | 1980 |
Effects of insulin on cultured rat brain cells: stimulation of ornithine decarboxylase activity.
Topics: Angiotensin II; Animals; Brain; Carboxy-Lyases; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Female; Glucagon; Growth Hormone; Insulin; Ornithine Decarboxylase; Pregnancy; Rats | 1981 |
Localization of [Met5]- and [Leu5]-enkephalin-like immunoreactivity in nerve terminals in human paravertebral sympathetic ganglia.
Topics: Adult; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fluorescent Antibody Technique; Ganglia, Sympathetic; Humans; Immune Sera; Male; Microscopy, Fluorescence; Middle Aged; Neurons | 1981 |
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.
Topics: Amino Acids, Sulfur; Animals; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Neprilysin; Potassium; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1981 |
Met-enkephalin-Arg6-Phe7 metabolism: conversion to Met-enkephalin by brain and kidney dipeptidyl carboxypeptidases.
Topics: Amino Acid Sequence; Animals; Brain; Endopeptidases; Endorphins; Enkephalin, Methionine; Enkephalins; Kidney; Kinetics; Mitochondria; Oligopeptides; Rabbits | 1981 |
Indication for central vagal endorphinergic control of heart rate in dogs.
Topics: Analgesia; Animals; Brain; Captopril; Dipeptides; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Heart Rate; Male; Oligopeptides; Phenylalanine; Physostigmine; Potassium; Puromycin; Vagus Nerve; Veratridine | 1981 |
In vivo characterization of the mechanisms that secrete enkephalin-like peptides stored in dog adrenal medulla.
Topics: Adrenal Medulla; Animals; Chromatography, High Pressure Liquid; Dogs; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Hydrolysis; Peptide Hydrolases; Receptors, Nicotinic; Splanchnic Nerves | 1981 |
Effects of intraventricular morphine and enkephalins on locomotor activity in nondependent, morphine-dependent and postdependent rats.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Rats; Time Factors | 1981 |
A distinct peptidyl dipeptidase that degrades enkephalin: exceptionally high activity in rabbit kidney.
Topics: Angiotensin I; Animals; Bradykinin; Chromatography, High Pressure Liquid; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kidney; Kinetics; Lung; Protease Inhibitors; Rabbits | 1981 |
Distribution of methionine-enkephalin immunoreactivity in the chick brain: an immunohistochemical study.
Topics: Animals; Brain; Brain Chemistry; Chickens; Cross Reactions; Endorphins; Enkephalin, Methionine; Enkephalins; Immunoenzyme Techniques; Organ Specificity | 1981 |
The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.
Topics: Animals; Behavior, Animal; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flupenthixol; Globus Pallidus; Male; Motor Activity; Naloxone; Organ Specificity; Rats; Tegmentum Mesencephali | 1981 |
Conversion of [met5]-enkephalin-Arg6-Phe7 to [met5]-enkephalin by dipeptidyl carboxypeptidase.
Topics: Animals; Brain Chemistry; Cattle; Corpus Striatum; Endopeptidases; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Microsomes; Pregnenediones; Steroids, Chlorinated | 1981 |
In vivo potentiation of [D-Ala2]Met-enkephalin amide central effects after administration of an enkephalinase inhibitor.
Topics: Animals; Brain; Dipeptides; Drug Synergism; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains | 1981 |
Evidence for a gamma-aminobutyric acid (GABA) mediation in the benzodiazepine inhibition of the release of Met5-enkephalin elicited by depolarization.
Topics: Animals; Benzodiazepines; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Isoniazid; Male; Membrane Potentials; Muscimol; Neprilysin; Potassium Chloride; Protease Inhibitors; Rats; Rats, Inbred Strains; Synaptic Membranes | 1982 |
Inhibition of dopamine biosynthesis by gonadotropin-releasing hormone in rat.
Topics: Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Gonadotropin-Releasing Hormone; Naloxone; Rats; Synaptosomes | 1982 |
Differential distribution in rat basal ganglia of Met-enkephalin- and Met-enkephalin Arg6 Phe7-like peptides revealed by immunohistochemistry.
Topics: Animals; Basal Ganglia; Caudate Nucleus; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Globus Pallidus; Histocytochemistry; Male; Peptides; Putamen; Rats; Rats, Inbred Strains; Tissue Distribution | 1982 |
Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5] enkephalin.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Captopril; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Injections, Spinal; Macaca; Morphine; Neprilysin; Protease Inhibitors; Rats; Species Specificity; Thiorphan; Tiopronin | 1982 |
Immunocytochemical and ultrastructural differentiation between Met-enkephalin-, Leu-enkephalin-, and Met/Leu-enkephalin-immunoreactive neurons of feline gut.
Topics: Animals; Cats; Cross Reactions; Digestive System; Duodenum; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fluorescent Antibody Technique; Immune Sera; Male; Microscopy, Electron; Myenteric Plexus; Neurons | 1982 |
Distribution of enkephalin-like immunoreactivity in the rat main olfactory bulb.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fluorescent Antibody Technique; Immunoenzyme Techniques; Male; Neural Inhibition; Olfactory Bulb; Rats; Rats, Inbred Strains | 1982 |
An enkephalin-generating enzyme in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Cattle; Chromatography, Affinity; Endopeptidases; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Serine Endopeptidases | 1982 |
The distribution of enkephalin immunoreactive fibers and terminals in the monkey central nervous system: an immunohistochemical study.
Topics: Animals; Brain; Brain Mapping; Chlorocebus aethiops; Diencephalon; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Macaca fascicularis; Macaca mulatta; Male; Medulla Oblongata; Mesencephalon; Nerve Fibers; Neural Pathways; Pons; Species Specificity; Spinal Cord; Telencephalon | 1982 |
Co-storage of enkephalins and adrenaline in the bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; Fluorescent Antibody Technique; Microscopy, Fluorescence; Norepinephrine | 1982 |
Depression of learned thermoregulatory behavior by central injection of opioids in cats.
Topics: Animals; Avoidance Learning; Body Temperature Regulation; Cats; Conditioning, Operant; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Morphine; Motor Activity; Pentazocine | 1982 |
Do enkephalins directly affect calcium-spikes in hippocampal pyramidal cells?
Topics: Action Potentials; Animals; Calcium; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Methionine; Enkephalins; Hippocampus; In Vitro Techniques; Rats; Tetrodotoxin | 1980 |
Inhibition of the enzymatic degradation of Met-enkephalin by catecholamines.
Topics: Adrenal Glands; Animals; Brain; Catecholamines; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Ileum; Puromycin; Rats | 1982 |
Effect of naloxone on met-enkephalin-induced gastric acid secretion and serum gastrin in man.
Topics: Adult; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Gastric Acid; Gastrins; Humans; Male; Middle Aged; Naloxone; Pentagastrin | 1982 |
Met-enkephalin inhibits mineralocorticoid production in isolated human aldosteronoma cells.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Corticosterone; Cosyntropin; Desoxycorticosterone; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Hydrocortisone; In Vitro Techniques; Mineralocorticoids | 1982 |
A carboxypeptidase processing enzyme for enkephalin precursors.
Topics: Adrenal Medulla; Animals; Carboxypeptidases; Cattle; Chromaffin Granules; Chromaffin System; Endorphins; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Protein Precursors; Subcellular Fractions | 1982 |
Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Evolution; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Protein Precursors; RNA, Messenger | 1982 |
270-MHz 1H nuclear-magnetic-resonance study of met-enkephalin in solvent mixtures. Conformational transition from dimethylsulphoxide to water.
Topics: Dimethyl Sulfoxide; Endorphins; Enkephalin, Methionine; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Conformation; Solutions; Temperature; Water | 1982 |
Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Pheochromocytoma; Radioimmunoassay; Sympathetic Nervous System | 1982 |
[Reaction between methionine enkephalin and human lymphocytes].
Topics: Binding Sites; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Lymphocytes | 1982 |
[Ethological analysis of the effect of enkephalins on the interspecies behavior].
Topics: Analgesics; Animals; Behavior, Animal; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ethology; Male; Mice; Mice, Inbred Strains; Species Specificity | 1982 |
Opiate alkaloids antagonize postsynaptic glycine and GABA responses: correlation with convulsant action.
Topics: Animals; Cells, Cultured; Dextrorphan; Enkephalin, Methionine; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Levorphanol; Mice; Morphine; Naloxone; Narcotics; Neural Inhibition; Neurons; Seizures; Spinal Cord; Synapses | 1982 |
The effect of methionine enkephalin on prolactin and luteinizing hormone levels in intact and castrated rats.
Topics: Animals; Castration; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Luteinizing Hormone; Male; Prolactin; Rats; Rats, Inbred Strains | 1982 |
Evaluation of the analgesic activity of morphine, enkephalins and their synthetic analogues.
Topics: Analgesics; Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Rabbits | 1982 |
Epidural met-enkephalin (FK 33-824). A dose-effect study.
Topics: Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Male; Middle Aged; Morphine; Pain, Postoperative; Time Factors | 1982 |
Effect of tones, footshocks, shuttle avoidance, and electroconvulsive shock on met-encephalin immunoreactivity of rat brain.
Topics: Amygdala; Animals; Avoidance Learning; Brain; Electroshock; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Hypothalamus; Pitch Perception; Rats; Rats, Inbred Strains | 1982 |
Effects of (D-alanine2, methionine5) enkephalinamide on the release of acetylcholine and noradrenaline from brain slices and isolated nerve terminals.
Topics: Acetylcholine; Animals; Brain; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Membrane Potentials; Norepinephrine; Potassium; Rats; Synaptosomes | 1982 |
Altered methionine enkephalin immunoreactivity in cerebral nuclei of spontaneously hypertensive rats.
Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Hypertension; Rats; Rats, Inbred Strains | 1982 |
Methionine enkephalin increases CNS suppressive control exerted over gill reflex behaviours and associated neural activity in Aplysia california.
Topics: Action Potentials; Animals; Aplysia; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Gills; Motor Neurons; Naloxone; Reflex | 1982 |
Effects of enkephalins versus opiates on locomotor activity of the horse.
Topics: Animals; Blinking; Blood Pressure; Body Temperature; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fentanyl; Horses; Morphine; Motor Activity; Respiration | 1982 |
Determination of methionine-enkephalin, norepinephrine, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and 3-methoxy-4-hydroxyphenylacetic acid (HVA) in brain by high-pressure liquid chromatography with electrochemical detector.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Enkephalin, Methionine; Enkephalins; Homovanillic Acid; Male; Mice; Norepinephrine; Phenylacetates; Rats; Rats, Inbred Strains | 1982 |
Increased levels of Met-enkephalin-like material in the CSF of anaesthetized cats after tooth pulp stimulation.
Topics: Animals; Cats; Cross Reactions; Cuspid; Dental Pulp; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Neurons; Nociceptors; Radioimmunoassay | 1982 |
Met-enkephalin [Arg6, Phe7] immunoreactivity in bovine caudate and bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Antibody Specificity; Cattle; Caudate Nucleus; Chromaffin Granules; Chromatography, Gel; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Methionine; Enkephalins; Radioimmunoassay | 1982 |
Effect of methionine-enkephalin and naloxone on bombesin-stimulated gastric acid secretion, gastrin, and pancreatic polypeptide release in the dog.
Topics: Animals; Bombesin; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Gastric Acid; Gastrins; Infusions, Parenteral; Naloxone; Pancreatic Polypeptide; Peptides; Stimulation, Chemical; Time Factors | 1982 |
Cell-free translation and partial characterization of proenkephalin messenger RNA from bovine striation.
Topics: Animals; Cattle; Cell-Free System; Chromatography, High Pressure Liquid; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Molecular Weight; Protein Biosynthesis; Protein Precursors; Rabbits; Reticulocytes; RNA, Messenger | 1982 |
Met-enkephalin immunoreactivity in blood platelets.
Topics: Adrenal Glands; Animals; Blood Platelets; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Hypertension; Male; Pituitary Gland; Rabbits; Radioimmunoassay; Rats; Rats, Inbred Strains; Serotonin; Thrombin | 1982 |
[Reaction between endogenous opiates and human peripheral blood lymphocytes].
Topics: Adenylyl Cyclase Inhibitors; Binding Sites; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Lymphocytes | 1982 |
Met-enkephalin as a modulator of smooth-muscle mechanical activity.
Topics: Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Rats; Rats, Inbred Strains | 1982 |
Amino acids and peptides. II. Modification of glycylglycine bond in methionine enkephalin.
Topics: Animals; Dipeptides; Endorphins; Enkephalin, Methionine; Enkephalins; Glycylglycine; Indicators and Reagents; Mice; Morphine; Structure-Activity Relationship | 1982 |
Reward produced by microinjection of (D-Ala2),Met5-enkephalinamide into the ventral tegmental area.
Topics: Animals; Conditioning, Operant; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Rats; Reward; Tegmentum Mesencephali | 1982 |
Opiate activation of potassium conductance in myenteric neurons: inhibition by calcium ion.
Topics: Animals; Calcium; Cell Membrane Permeability; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Morphine; Myenteric Plexus; Potassium | 1982 |
The assay of Met-enkephalin aminopeptidase with [125I]Met-enkephalin.
Topics: Aminopeptidases; Animals; Brain; Centrifugation, Density Gradient; Endorphins; Enkephalin, Methionine; Enkephalins; Hydrolysis; Kinetics; Methods; Puromycin; Rats; Time Factors; Tyrosine | 1982 |
Measurement of methionine-enkephalin [Arg6,Phe7] in rat brain by specific radioimmunoassay directed at methionine sulphoxide enkephalin[Arg6,Phe7].
Topics: Animals; Brain Chemistry; Corpus Striatum; Cross Reactions; Endorphins; Enkephalin, Methionine; Enkephalins; Radioimmunoassay; Rats; Tissue Distribution | 1982 |
Lack of effect of morphine and noxious stimuli on the MET-enkephalin content in the spinal dorsal horn and nucleus reticularis gigantocellularis of the rat.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Formaldehyde; Hot Temperature; Male; Medulla Oblongata; Morphine; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord | 1982 |
Distribution of met-enkephalin-Arg6-Phe7 in various tissues of rats and guinea pigs.
Topics: Adrenal Glands; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Ganglia, Sympathetic; Gastric Mucosa; Guinea Pigs; Intestinal Mucosa; Liver; Lung; Male; Myocardium; Pancreas; Rats; Rats, Inbred Strains | 1982 |
Cell-free translation of enkephalin-precursor messenger RNA from bovine adrenal medulla and corpus striatum.
Topics: Adrenal Medulla; Animals; Cattle; Cell-Free System; Corpus Striatum; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Protein Biosynthesis; Rabbits; RNA, Messenger | 1982 |
Enzymatic production of Met5- and Leu5-enkephalin in adrenal chromaffin granules.
Topics: Adrenal Medulla; Animals; Cattle; Chromaffin Granules; Chromaffin System; Chromatography, Affinity; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Molecular Weight; Peptide Biosynthesis; Trypsin Inhibitors | 1982 |
Current studies on enkephalin biosynthesis.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Catecholamines; Cattle; Chromaffin System; Enkephalin, Methionine; Enkephalins; Humans; Molecular Weight; Rats; Species Specificity | 1982 |
Production and regulation of enkephalin-like peptides in neuroblastoma x glioma cells.
Topics: Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Humans; Hybrid Cells; Neoplasms, Experimental; Neuroblastoma; Steroids | 1982 |
Calcium ions reduce enkephalin hyperpolarization of myenteric neurones.
Topics: Animals; Calcium; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Myenteric Plexus; Neural Conduction; Neurons; Potassium | 1982 |
Existence of Met-enkephalin-Arg6-Gly7-Leu8 with Met-enkephalin, Leu-enkephalin and Met-enkephalin-Arg6-Phe7 in the brain of guinea pig, rat and golden hamster.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cricetinae; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Mesocricetus; Radioimmunoassay; Rats; Species Specificity | 1982 |
Effects of enkephalins on perfusion pressure in isolated hindlimb preparations.
Topics: Animals; Blood Pressure; Cats; Diphenhydramine; Dose-Response Relationship, Drug; Drug Antagonism; Enkephalin, Leucine; Enkephalin, Methionine; Female; Femoral Artery; In Vitro Techniques; Injections, Intra-Arterial; Male; Naloxone; Perfusion; Propranolol; Vasodilation | 1982 |
Enkephalin-containing sympathetic preganglionic neurons projecting to the inferior mesenteric ganglion: evidence from combined retrograde tracing and immunohistochemistry.
Topics: Adrenergic Fibers; Animals; Autonomic Fibers, Preganglionic; Enkephalin, Leucine; Enkephalin, Methionine; Ganglia, Sympathetic; Guinea Pigs; Male; Microscopy, Fluorescence; Neurons; Spinal Cord | 1982 |
Changes in plasma cortisol and progesterone after administration of enkephalins to newborn lambs.
Topics: Animals; Animals, Newborn; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hydrocortisone; Male; Progesterone; Sheep; Time Factors | 1982 |
Interactions between serotonergic and enkephalinergic neurons in rat striatum and hypothalamus.
Topics: Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Hypothalamus; Kinetics; Male; Neurons; Rats; Rats, Inbred Strains; Serotonin | 1982 |
[Modulation of the functioning of muscarinic and nicotinic cholinoreceptors of dialyzed snail neurons by opiate peptides and morphine].
Topics: Acetylcholine; Animals; Drug Interactions; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Helix, Snails; In Vitro Techniques; Morphine; Neurons; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic | 1982 |
Met- and leu-enkephalin immuno- and bio-reactivity in human stomach and pancreas.
Topics: Chromatography, Gel; Cross Reactions; Cyanogen Bromide; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Pancreas; Radioimmunoassay; Radioligand Assay; Stomach; Tissue Extracts | 1982 |
A new approach to conformationally restricted peptide analogs: rigid beta-bends. 1. Enkephalin as an example.
Topics: Animals; Biological Assay; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Models, Molecular; Muscle Contraction; Protein Conformation; Structure-Activity Relationship | 1982 |
Enkephalin actions on avoidance conditioning may be related to adrenal medullary function.
Topics: Adrenal Medulla; Animals; Avoidance Learning; Conditioning, Psychological; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Male; Norepinephrine; Rats; Rats, Inbred Strains | 1982 |
The distribution of enkephalin immunoreactive neuronal cell bodies in the monkey brain: preliminary observations.
Topics: Animals; Brain; Brain Mapping; Brain Stem; Chlorocebus aethiops; Diencephalon; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Macaca fascicularis; Neurons; Telencephalon | 1982 |
Methionine-enkephalin antagonism and endorphin potentiation of narcotic-induced analgesia.
Topics: Animals; Drug Interactions; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Reaction Time | 1980 |
Histidyl-proline diketopiperazine decreases food intake in rats.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Feeding Behavior; Humans; Male; Peptides, Cyclic; Piperazines; Rats; Starvation; Stress, Psychological; Structure-Activity Relationship | 1981 |
Retrograde amnesia caused by Met-, Leu- and des-Try-Met-enkephalin in the rat and its reversal by naloxone.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Drug Antagonism; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; Kinetics; Naloxone; Rats | 1981 |
The effect of naloxone on enkephalin catabolism.
Topics: Aminopeptidases; Animals; Biotransformation; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Male; Mice; Morphine Dependence; Naloxone; Protease Inhibitors | 1981 |
Pharmacological characterization of opiate physical dependence in the isolated ileum of the guinea-pig.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Levorphanol; Male; Morphine; Nalorphine; Naloxone; Narcotics; Pentazocine; Substance-Related Disorders; Time Factors | 1981 |
Effects of intraventricular morphine and enkephalins on schedule-controlled behavior in nondependent, morphine-dependent and postdependent rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1981 |
The role of the pituitary in the diurnal variation in tolerance to painful stimuli and brain enkephalin levels.
Topics: Animals; Brain; Circadian Rhythm; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Hypophysectomy; Male; Mice; Naloxone; Pain; Pituitary Gland; Prolactin; Rats; Stress, Psychological | 1981 |
Central neuropharmacology of D-Ala2-Met-enkephalinamide and its interactions with taurine in rats.
Topics: Analgesia; Animals; Catatonia; Corpus Striatum; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Humans; Leucine; Male; Rats; Rats, Inbred Strains; Seizures; Taurine | 1981 |
Contraversive circling and facilitation of the perioral biting reflex by injection of substance P or D-Ala2-Met-encephalinamide into the substantia nigra.
Topics: Animals; Appetitive Behavior; Dominance, Cerebral; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Male; Muscimol; Naloxone; Predatory Behavior; Rats; Rats, Inbred Strains; Reflex; Stereotyped Behavior; Substantia Nigra | 1982 |
Diurnal fluctuations in methionine-enkephalin levels in the hypothalamus and preoptic area of the male rat: effects of pinealectomy.
Topics: Animals; Circadian Rhythm; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Pineal Gland; Preoptic Area; Rats; Testosterone | 1982 |
Stimulation of pulmonary J receptors by an enkephalin-analog.
Topics: Animals; Blood Pressure; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Phrenic Nerve; Pulmonary Artery; Rats; Respiration; Sensory Receptor Cells; Stimulation, Chemical | 1981 |
A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.
Topics: Adrenal Medulla; Amino Acid Sequence; Amino Acids; Animals; Biological Assay; Cattle; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Protein Precursors | 1980 |
Adrenal cortex - a newly recognized peripheral site of action of enkephalins.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Aldosterone; Animals; Calcium; Cattle; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kinetics; Male; Rats | 1980 |
Differential loss of biological activity of the enkephalins induced by current.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Male; Mice; Muscle, Smooth; Vas Deferens | 1981 |
Degradation of enkephalin and enkephalinamide by neuroblastoma x glioma hybrid cells as studied by 13C n.m.r.
Topics: Cell Membrane; Chromatography, Thin Layer; Endorphins; Enkephalin, Methionine; Enkephalins; Glioma; Humans; Hybrid Cells; Magnetic Resonance Spectroscopy; Neuroblastoma; Puromycin; Trypsin | 1980 |
In vivo release of met-enkephalin in the cat brain.
Topics: Animals; Brain; Catheterization; Cats; Caudate Nucleus; Cross Reactions; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Globus Pallidus; Immune Sera; Male; Radioimmunoassay | 1981 |
De novo biosynthesis of enkephalins and their homologues in the human placenta.
Topics: Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; In Vitro Techniques; Peptide Fragments; Placenta; Pregnancy; Radioimmunoassay; Tyrosine | 1981 |
Spreading depression induced by microinjection of enkephalins into the hippocampus and neocortex.
Topics: Animals; Cerebral Cortex; Cortical Spreading Depression; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hippocampus; Male; Membrane Potentials; Naloxone; Rats | 1981 |
Peristalsis abolishes the release of methionine-enkephalin from guinea-pig ileum in vitro.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Naloxone; Peristalsis | 1981 |
Difference in the development of tolerance to morphine and D-ALA2-methionine-enkephalin in C57 BL/6J and DBA/2J mice.
Topics: Analgesia; Analgesics; Animals; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine | 1981 |
Enkephalin congeners and precursors are synthesized and released by primary cultures of adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Nicotine; Protein Precursors | 1981 |
Morphine and delta-opiate agonists locally stimulate in vivo dopamine release in cat caudate nucleus.
Topics: Animals; Cats; Caudate Nucleus; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Morphine; Naloxone | 1981 |
Pupillary effects of leucine and methionine enkephalin in rats after intraperitoneal administration.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Morphine; Naloxone; Pupil; Rats; Structure-Activity Relationship | 1980 |
Solubilization and characterization of two rat brain membrane-bound aminopeptidases active on Met-enkephalin.
Topics: Aminopeptidases; Animals; Brain; Cations, Divalent; Cell Membrane; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Kinetics; Male; Rats; Solubility; Substrate Specificity | 1981 |
A comparison of the anticonvulsant effects of two systemically active enkephalin analogues in rats.
Topics: Animals; Anticonvulsants; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Flurothyl; Male; Naloxone; Rats; Seizures | 1981 |
Methionine enkephalin-induced shaking behavior in rats: dissociation from brain serotonin mechanisms.
Topics: Animals; Brain; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Norepinephrine; Rats; Receptors, Serotonin; Serotonin; Tremor | 1981 |
Effect of methionine-enkephalin on xanthopore aggregation.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Goldfish; Melatonin; Naloxone; Skin; Skin Physiological Phenomena | 1980 |
Effects of taurine and gamma-aminobutyric acid on akinesia and analgesia induced by D-Ala2-Met-enkephalinamide in rats.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Leucine; Male; Movement; Rats; Taurine | 1980 |
Tyrosine-modified analogs of methionine-enkephalin and their effects on the mouse vas deferens.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mice; Muscle Contraction; Structure-Activity Relationship; Vas Deferens | 1980 |
Cell-free translation of human pheochromocytoma messenger RNA yields protein(s) containing methionine-enkephalin.
Topics: Adrenal Gland Neoplasms; Cell-Free System; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Molecular Weight; Pheochromocytoma; Protein Biosynthesis; RNA, Messenger | 1981 |
Isolation and identification of an analgesic opioid dipeptide kyotorphin (Tyr-Arg) from bovine brain.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Cattle; Cisterna Magna; Dipeptides; Endorphins; Enkephalin, Methionine; Enkephalins; Injections; Male; Mice; Morphine | 1981 |
Effects of intravenously administered Leu- or Met-enkephalin on arterial blood pressure.
Topics: Animals; Blood Pressure; Cats; Diphenhydramine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Injections, Intravenous; Male; Naloxone; Propranolol | 1980 |
[Effect of enkephalins on central processes regulating hemodynamics].
Topics: Animals; Blood Pressure; Cats; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Heart Rate; Hemodynamics; Hypothalamus; Injections, Intraventricular; Medulla Oblongata; Pressoreceptors; Reflex | 1981 |
Differential response to methionine-enkephalin in basal hypothalamus and preoptic area following hypothalamic deafferentation.
Topics: Afferent Pathways; Animals; Castration; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Hypothalamus; Organ Specificity; Preoptic Area; Rats | 1981 |
Met-enkephalin concentrations in individual brain nuclei of ansa lenticularis and stria terminalis transected rats.
Topics: Amygdala; Animals; Brain; Brain Stem; Caudate Nucleus; Endorphins; Enkephalin, Methionine; Enkephalins; Globus Pallidus; Hypothalamus; Limbic System; Median Eminence; Neural Pathways; Putamen; Radioimmunoassay; Rats; Substantia Nigra | 1981 |
Immunohistochemical evidence of methionine enkephalin-like material in the brain of the migratory locust.
Topics: Animals; Brain; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Grasshoppers; Nerve Fibers; Neurons; Neurosecretory Systems; Optic Lobe, Nonmammalian | 1981 |
Sensitive and specific high performance liquid chromatographic method for methionine and leucine enkephalins.
Topics: Adrenal Glands; Amino Acid Sequence; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Rabbits; Radioimmunoassay | 1981 |
Rapid depletion and restoration of striatal met-enkephalin after ketamine.
Topics: Animals; Corpus Striatum; Diazepam; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Ketamine; Male; Rats | 1981 |
Clozapine inhibition of metenkephalin binding to synaptosome-enriched fractions of rat whole brain and hippocampus.
Topics: Animals; Brain; Chlorpromazine; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Haloperidol; Hippocampus; Prochlorperazine; Rats; Synaptosomes | 1981 |
Purification and characterization of an enkephalin aminopeptidase from rat brain.
Topics: Aminopeptidases; Animals; Brain; Chromatography, Gel; Chromatography, Ion Exchange; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Weight; Rats; Subcellular Fractions; Temperature; Zinc | 1981 |
The effects of morphine and methionine-enkephalin on the release of purines from cerebral cortex slices of rats and mice.
Topics: Animals; Calcium; Cerebral Cortex; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Ouabain; Purine Nucleosides; Rats; Rats, Inbred Strains | 1981 |
Mechanism of kyotorphin-induced release of Met-enkephalin from guinea pig striatum and spinal cord.
Topics: Animals; Calcium; Corpus Striatum; Dipeptides; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Potassium; Spinal Cord; Tetrodotoxin | 1981 |
Thermoregulatory effects of centrally administered bombesin, bradykinin, and methionine-enkephalin.
Topics: Animals; Body Temperature Regulation; Bombesin; Bradykinin; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Peptides; Rats; Skin Temperature; Vasoconstriction; Vasodilation | 1981 |
Methionine-enkephalin and morphine: amount ejected microiontophoretically.
Topics: Animals; Biological Transport; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Iontophoresis; Kinetics; Microinjections; Morphine; Neurons; Tritium | 1981 |
Enkephalins induce asymmetrical effects on posture in the rat.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Functional Laterality; Hindlimb; Male; Naloxone; Phosphorylases; Posture; Rats; Spinal Cord | 1981 |
Conversion of Met-enkephalin-Arg6-Phe7 by a purified brain carboxypeptidase (cathepsin A).
Topics: Amino Acid Sequence; Animals; Brain; Carboxypeptidases; Cathepsin A; Cathepsins; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Rats; Substrate Specificity | 1981 |
The lipolytic activity of met-enkephalin, leu-enkephalin, morphine, methadone and naloxone in human adipose tissue.
Topics: Adipose Tissue; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fatty Acids, Nonesterified; Female; Humans; Lipolysis; Male; Methadone; Naloxone | 1981 |
[Effect of leu- and met-enkephalins on the brain's reinforcement systems].
Topics: Animals; Avoidance Learning; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Mesencephalon; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement, Psychology; Self Stimulation | 1981 |
Enkephalin-induced inhibition of the isolated rat ileum is not blocked by naloxone.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Rats, Inbred Strains | 1981 |
[Possible mechanisms of peripheral stimulation analgesia. Neurophysiologic and neuropharmacologic studies].
Topics: Acupuncture Therapy; Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Naloxone; Nociceptors | 1981 |
Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo.
Topics: Animals; Bradykinin; Cats; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Mesencephalon; Morphine; Nerve Block; Rest; Sciatic Nerve; Spinal Cord; Trigeminal Nerve | 1981 |
Brain content of leu5- and met5-enkephalin changes independently during the development of kindling in the rat.
Topics: Amygdala; Animals; Brain Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Time Factors | 1981 |
Absence of seizure activity following focal cerebral injection of enkephalins in a primate.
Topics: Amygdala; Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electroencephalography; Enkephalin, Methionine; Enkephalins; Hippocampus; Injections, Intraventricular; Light; Morphine; Narcotics; Papio; Seizures; Thalamus | 1981 |
Conformational studies of dansylated enkephalins by fluorescence transfer measurements, proton nuclear magnetic resonance spectroscopy, and theoretical calculations.
Topics: Dansyl Compounds; Endorphins; Enkephalin, Methionine; Enkephalins; Magnetic Resonance Spectroscopy; Mathematics; Protein Conformation; Spectrometry, Fluorescence | 1981 |
Hemodynamic and metabolic changes during stimulation of ileal motility.
Topics: Acetylcholine; Angiotensin II; Animals; Dogs; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Ileum; Intestinal Mucosa; Male; Microspheres; Morphine; Prostaglandins D; Prostaglandins F; Splanchnic Circulation | 1981 |
Differential effects of enkephalin within hippocampal areas.
Topics: Animals; Bicuculline; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hippocampus; In Vitro Techniques; Naloxone; Neurons; Rats | 1981 |
Liquid-phase synthesis of naturally occurring peptides, I. Syntheses of leucine-enkephalin and methionine-enkephalin of a p-alkoxybenzyl-modified soluble support.
Topics: Amino Acids; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Indicators and Reagents; Methods | 1981 |
Antidepressants inhibit enkephalin binding to synaptosome-enriched fractions of rat brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Imipramine; Male; Nortriptyline; Rats; Rats, Inbred Strains; Synaptosomes; Viloxazine | 1981 |
[Inhibitory effect of methionine enkephalin and morphine on pentagastrin-stimulated gastric secretion in dogs].
Topics: Animals; Dogs; Endorphins; Enkephalin, Methionine; Enkephalins; Gastric Mucosa; Morphine; Naloxone; Pentagastrin | 1981 |
Central peptidergic stimulation in blood pressure control: role of enkephalins in rats.
Topics: Animals; Blood Pressure; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains | 1981 |
Met-enkephalin uptake by a synaptosome-enriched fraction of rat striatum.
Topics: Animals; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Rats; Rats, Inbred Strains; Synaptosomes; Temperature; Tritium | 1981 |
Fast-atom-bombardment mass spectra of enkephalins.
Topics: Anions; Cations; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mass Spectrometry | 1981 |
Effect of enkephalins in the presence of the antibiotic bacitracin in the longitudinal muscle strip preparation from guinea-pig ileum.
Topics: Animals; Bacitracin; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth | 1981 |
Accurate measurement of intestinal transit in the rat.
Topics: Analysis of Variance; Animals; Capsaicin; Catheters, Indwelling; Chromium Radioisotopes; Duodenum; Enkephalin, Methionine; Enkephalins; Female; Hexamethonium Compounds; Intestine, Small; Neostigmine; Rats; Rats, Inbred Strains; Regression Analysis; Sodium Chloride; Tissue Distribution | 1981 |
Enkephalin-related peptides: direct action on the octopus heart.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Heart; Heart Rate; Male; Naloxone; Octopodiformes | 1981 |
Cardiopulmonary pharmacology of enkephalins in the conscious dog.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Heart Rate; Hemodynamics; Injections, Intra-Arterial; Injections, Intravenous; Respiration | 1981 |
Identification of the octapeptide [Met]enkephalin -Arg6-Gly7-Leu8 in extracts of bovine adrenal medulla.
Topics: Adrenal Medulla; Amino Acids; Animals; Carboxypeptidases; Cattle; Chromaffin Granules; Chromaffin System; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics | 1981 |
Enhanced analgesic activity of liposomised Met-enkephalin analogue.
Topics: Analgesia; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Liposomes; Mice; Naloxone | 1981 |
Stable isolated symmetrical anhydrides of N alpha-9-fluorenylmethyloxycarbonylamino acids in solid-phase peptide synthesis. Methionine-enkephalin synthesis as an example.
Topics: Amino Acids; Anhydrides; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Fluorenes | 1981 |
'Acetaldehyde-enkephalins': elucidation of the structure of the acetaldehyde adducts of methionine-enkephalin and leucine-enkephalin.
Topics: Chemical Phenomena; Chemistry; Dimethyl Sulfoxide; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Magnetic Resonance Spectroscopy; Protein Binding; Protein Conformation | 1980 |
Occurrence of methionine enkephalin in human placental villus.
Topics: Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Placenta; Pregnancy; Radioimmunoassay | 1980 |
Morphine and methionine-enkephalin: different effects on spontaneous and evoked neuronal firing in the mesencephalic reticular formation of the rat.
Topics: Action Potentials; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Iontophoresis; Male; Mesencephalon; Morphine; Neurons; Pain; Rats; Reticular Formation | 1980 |
[Measurement of methionine-enkephalin-like substance in CSF from normal subjects and patients with pituitary adenoma (author's transl)].
Topics: Adenoma; Adolescent; Adult; Aged; Cushing Syndrome; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Male; Middle Aged; Pituitary Neoplasms; Radioligand Assay | 1980 |
Benzodiazepines modulate striatal enkephalin levels via a GABAergic mechanism.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Corpus Striatum; Diazepam; Endorphins; Enkephalin, Methionine; Enkephalins; Fentanyl; gamma-Aminobutyric Acid; Hypothalamus; Male; Muscimol; Radioimmunoassay; Rats | 1980 |
The effect of (D-Ala2)-Met-enkephalin on the contraction of nictitating membrane in cats.
Topics: Animals; Cats; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Morphine; Muscle Contraction; Naloxone; Nictitating Membrane; Norepinephrine; Sympathetic Nervous System | 1980 |
Effect of met-enkephalin on the responses of rat fundus and colon and chick rectum to PGE2 and its release from rat aortic strip.
Topics: Animals; Aorta; Blood Vessels; Chickens; Colon; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Prostaglandins E; Rats; Rectum; Stomach | 1980 |
An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin.
Topics: Adrenal Medulla; Animals; Cattle; Chromaffin Granules; Chromaffin System; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Molecular Weight; Oligopeptides; Peptide Fragments; Protein Precursors; Proteins; Trypsin | 1980 |
Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Locus Coeruleus; Membrane Potentials; Morphine Derivatives; Naloxone; Neurons | 1980 |
Release of methionine-enkephalin immunoreactivity from the rat spinal cord in vivo.
Topics: Animals; Blood Pressure; Calcium; Cobalt; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Potassium; Radioimmunoassay; Rats; Spinal Cord | 1980 |
Biochemical characterization of the dopaminergic innervation of the rat septum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Apomorphine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Haloperidol; Kinetics; Male; Rats; Receptors, Dopamine; Septum Pellucidum; Spiperone | 1980 |
Effects of intraventricular beta-endorphin and D-ALA2-methionine-enkephalinamide on behaviour, spectrum power of electrocortical activity and body temperature in chicks.
Topics: Animals; Behavior, Animal; Body Temperature; Chickens; Electroencephalography; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Time Factors | 1980 |
Diazepam effects on striatal met-enkephalin levels following long-term pharmacological manipulations.
Topics: Animals; Corpus Striatum; Diazepam; Endorphins; Enkephalin, Methionine; Enkephalins; Flunitrazepam; Male; Rats | 1980 |
Myogenic receptivity for Met-enkephalin in the rat duodenum: comparison with the guinea-pig duodenum.
Topics: Animals; Drug Interactions; Duodenum; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Rats; Species Specificity; Tetrodotoxin | 1980 |
Proteases as catalysts for enzymic syntheses of opioid peptides.
Topics: Amino Acids; Animals; Biological Assay; Chymotrypsin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Indicators and Reagents; Male; Methods; Mice; Papain; Vas Deferens | 1980 |
Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin.
Topics: Aging; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Luteinizing Hormone; Male; Morphine; Naloxone; Rats; Testosterone | 1980 |
Stimulation of in vitro prolactin release by vasoactive intestinal peptide.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Gastrointestinal Hormones; Male; Naloxone; Prolactin; Rats; Vasoactive Intestinal Peptide | 1980 |
A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P).
Topics: Adrenal Medulla; Amino Acid Sequence; Amino Acids; Animals; Cattle; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hydrolysis; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Protein Precursors; Radioimmunoassay; Trypsin | 1980 |
Modulation of synaptosomal GABA release by enkephalin.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naloxone; Potassium; Rats; Synaptosomes | 1980 |
EEG and behavioral effects of morphine, enkephalins and derivatives administered into the lateral cerebral ventricles of rats and rabbits.
Topics: Animals; Behavior, Animal; Cerebral Ventricles; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Electroencephalography; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Injections, Intraventricular; Male; Morphine; Nalorphine; Rabbits; Rats; Seizures | 1980 |
Naloxone-reversible effects of d-Ala2-Met5-enkephalinamide-induced behavioral activity in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Male; Morphine; Motor Activity; Naloxone; Rats | 1980 |
Characterization of enkephalin release from rat striatum.
Topics: Animals; Corpus Striatum; Cross Reactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Potassium; Radioimmunoassay; Rats | 1981 |
Leucine-enkephalin and methionine-enkephalin produce opposing effects on plasma corticosterone levels in ether-stressed mice.
Topics: Animals; Corticosterone; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ether; Ethyl Ethers; Hypothalamo-Hypophyseal System; Male; Mice; Pituitary-Adrenal System; Stress, Physiological | 1980 |
Action of enkephalin analogues and morphine on brain acetylcholine release: differential reversal by naloxone and an opiate pentapeptide.
Topics: Acetylcholine; Animals; Brain; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Morphine; Naloxone; Rats | 1980 |
Novel met-enkephalin analogue: a potent systemic mu agonist antinociceptive agent.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Male; Mice; Mice, Inbred ICR; Receptors, Opioid, mu; Time Factors; Water | 1995 |
Preparative and analytical capillary zone electrophoresis analysis of native endorphins and enkephalins extracted from the bovine pituitary: mass spectrometric confirmation of the molecular mass of leucine enkephalin.
Topics: Animals; beta-Endorphin; Capillary Action; Cattle; Chromatography, High Pressure Liquid; Electrophoresis; Endorphins; Enkephalin, Methionine; Enkephalins; Molecular Weight; Neuropeptides; Pituitary Gland; Spectrometry, Mass, Secondary Ion | 1995 |
Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons.
Topics: Amino Acid Sequence; Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; GTP-Binding Proteins; In Vitro Techniques; Molecular Sequence Data; Naloxone; Nerve Endings; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Reticular Formation; Substance P | 1993 |
The role of neuropeptides in the regulation of adrenal zona glomerulosa function: effects of substance P, neuropeptide Y, neurotensin, Met-enkephalin, Leu-enkephalin and corticotrophin-releasing hormone on aldosterone secretion in the intact perfused rat
Topics: Aldosterone; Animals; Corticotropin-Releasing Hormone; Enkephalin, Leucine; Enkephalin, Methionine; Male; Neuropeptide Y; Neuropeptides; Neurotensin; Perfusion; Rats; Rats, Wistar; Substance P; Zona Glomerulosa | 1994 |
Effects of intranigral injections of colchicine on the expression of some neuropeptides in the rat forebrain: an immunohistochemical and in situ hybridization study.
Topics: Animals; Colchicine; Enkephalin, Methionine; Enkephalins; Gene Expression; Immunohistochemistry; In Situ Hybridization; Injections; Neuropeptide Y; Neuropeptides; Prosencephalon; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Substance P; Substantia Nigra; Tyrosine 3-Monooxygenase | 1994 |
An immunohistochemical study of the telencephalon and the diencephalon in a Myxinoid jawless fish, the Pacific hagfish, Eptatretus stouti.
Topics: Acetylcholinesterase; alpha-MSH; Animals; Brain Mapping; Diencephalon; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hagfishes; Immunoenzyme Techniques; Male; Neural Pathways; Neuropeptides; Species Specificity; Substance P; Telencephalon; Tyrosine 3-Monooxygenase | 1994 |
Alterations in acetylcholinesterase and choline acetyltransferase activities and neuropeptide levels in the ventral spinal cord of the Wobbler mouse during inherited motoneuron disease.
Topics: Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Neuropeptides; Reference Values; Sex Factors; Spinal Cord; Substance P; Thyrotropin | 1994 |
The role of neuropeptides in the regulation of adrenal vascular tone: effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, neurotensin, Met-enkephalin, and Leu-enkephalin on perfusion medium flow rate in the intact perfused rat adren
Topics: Adrenal Glands; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Male; Neuropeptide Y; Neuropeptides; Neurotensin; Rats; Rats, Wistar; Regional Blood Flow; Substance P; Vasoactive Intestinal Peptide | 1994 |
Opioid inhibition of Ih via adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cations; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ion Channels; Neurons; Nodose Ganglion | 1994 |
Demonstration of peptidergic afferents to the bed nucleus of the stria terminalis using local injections of colchicine. A combined immunohistochemical and retrograde tracing study.
Topics: Animals; Axonal Transport; Carbocyanines; Colchicine; Enkephalin, Methionine; Enkephalins; Horseradish Peroxidase; Ibotenic Acid; Immunohistochemistry; Male; Neurons, Afferent; Neuropeptides; Neurotensin; Rats; Rats, Wistar; Substance P; Thalamic Nuclei; Tyrosine 3-Monooxygenase; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1994 |
The role of neuropeptides in the regulation of adrenal zona fasciculata/reticularis function. Effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, Met- and Leu-enkephalin and neurotensin on corticosterone secretion in the intact perf
Topics: Adrenal Glands; Animals; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Male; Neuropeptide Y; Neuropeptides; Neurotensin; Perfusion; Rats; Rats, Wistar; Substance P; Vasoactive Intestinal Peptide; Zona Fasciculata; Zona Reticularis | 1994 |
[Expression of nitric oxide synthase in enkephalin and dynorphin systems of the rat hypothalamus].
Topics: Amino Acid Oxidoreductases; Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Histocytochemistry; Hypothalamus; Immunohistochemistry; Male; NADPH Dehydrogenase; Neurons; Nitric Oxide Synthase; Rats | 1994 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Neurotrophic factor gene expression in astrocytes during development and following injury.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Male; Nerve Growth Factors; Nerve Tissue Proteins; Nucleic Acid Hybridization; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; RNA; Substantia Nigra; Sympathectomy, Chemical | 1994 |
Opioid peptides content in the rat brain during the ictal phase and after pentylenetetrazol-kindled rats.
Topics: Animals; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Kindling, Neurologic; Male; Pentylenetetrazole; Radioimmunoassay; Rats; Rats, Wistar; Seizures; Time Factors; Tissue Distribution | 1995 |
Development of peptide-containing nerves in the human fetal prostate gland.
Topics: Bombesin; Calcitonin Gene-Related Peptide; Dopamine beta-Hydroxylase; Embryonic and Fetal Development; Enkephalin, Leucine; Enkephalin, Methionine; Epithelium; Female; Humans; Immunohistochemistry; Male; Neuropeptide Y; Neuropeptides; Pregnancy; Pregnancy Trimester, Second; Prostate; Somatostatin; Substance P; Thiolester Hydrolases; Tyrosine 3-Monooxygenase; Ubiquitin Thiolesterase; Urethra; Vasoactive Intestinal Peptide | 1995 |
Enzymatic peptide synthesis in low water content systems: preparative enzymatic synthesis of [Leu]- and [Met]-enkephalin derivatives.
Topics: Amino Acid Sequence; Bromelains; Chymotrypsin; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Molecular Sequence Data; Papain; Solvents; Thermolysin; Water | 1995 |
Complex avoidance behaviour and its neurochemical regulation in the land snail Cepaea nemoralis.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; FMRFamide; Hot Temperature; Invertebrate Hormones; Methysergide; Neuropeptides; Neurotransmitter Agents; Opioid Peptides; Serotonin; Snails | 1995 |
The fetal expression of proenkephalin mRNAs and Met-enkephalin immunoreactivity in the hypothalamoseptal tract and adjacent hypothalamic areas of the guinea pig brain.
Topics: Animals; Animals, Newborn; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Fetus; Guinea Pigs; Hypothalamus; Immunohistochemistry; Neural Pathways; Protein Precursors; RNA, Messenger; Septum Pellucidum | 1995 |
Enkephalins stimulate leukemia cell migration and surface expression of CD9.
Topics: Antigens, CD; Burkitt Lymphoma; Cell Line; Cell Movement; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Fluorescent Antibody Technique; Humans; Kinetics; Membrane Glycoproteins; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Tetraspanin 29; Tumor Cells, Cultured | 1995 |
Delta opioid agonists inhibit proliferation of highlypurified murine CD4+ and CD8+ T-cells.
Topics: Analgesics; Animals; CD4 Antigens; CD8 Antigens; Cell Division; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; T-Lymphocytes | 1995 |
Direct and indirect enkephalinergic synaptic inputs to the rat arcuate nucleus studied by combination of retrograde tracing and immunocytochemistry.
Topics: Afferent Pathways; Amino Acid Sequence; Animals; Arcuate Nucleus of Hypothalamus; Axonal Transport; Brain Mapping; Brain Stem; Diencephalon; Enkephalin, Methionine; Enkephalins; Gold; Horseradish Peroxidase; Hypothalamus; Male; Microscopy, Immunoelectron; Molecular Sequence Data; Rats; Rats, Wistar; Synapses; Telencephalon; Wheat Germ Agglutinins | 1993 |
Ultrastructure of Met5-enkephalin terminals in the caudate-putamen nuclei of adult rats receiving neonatal intranigral 6-hydroxydopamine.
Topics: Animals; Autoradiography; Dopamine; Enkephalin, Methionine; Enkephalins; Immunohistochemistry; Lesch-Nyhan Syndrome; Male; Microscopy, Electron; Neostriatum; Oxidopamine; Protein Precursors; Rats; Receptors, Opioid; Synapses | 1994 |
Antinociceptive effect of intracerebroventricular injection of a tetrapeptide Asn-Ala-Gly-Ala in rats.
Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Intraventricular; Male; Naloxone; Oligopeptides; Pain Threshold; Rats; Rats, Sprague-Dawley | 1994 |
Effects of ethanolic extracts from Eschscholtzia californica and Corydalis cava on dimerization and oxidation of enkephalins.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Isoquinolines; Kinetics; Monophenol Monooxygenase; Oxidation-Reduction; Peroxidases; Plant Extracts; Plants, Medicinal | 1995 |
Brain and plasma levels of opioid peptides are altered in rats with thioacetamide-induced fulminant hepatic failure: implications for the treatment of hepatic encephalopathy with opioid antagonists.
Topics: Animals; beta-Endorphin; Brain Chemistry; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hepatic Encephalopathy; Male; Motor Activity; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Sprague-Dawley; Thioacetamide | 1995 |
Met-enkephalin-containing peptides encoded by proenkephalin A mRNA expressed in activated murine thymocytes inhibit thymocyte proliferation.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; Blotting, Northern; Cell Division; Concanavalin A; DNA, Antisense; Enkephalin, Methionine; Enkephalins; Female; Mice; Mice, Inbred ICR; Molecular Sequence Data; Nucleic Acid Hybridization; Oligopeptides; Protein Precursors; Radioimmunoassay; Receptors, Opioid, delta; RNA, Messenger; Thymus Gland | 1995 |
Action of opioid peptides on the rat adrenal cortex: stimulation of steroid secretion through a specific mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Cortex; Aldosterone; Analgesics; Animals; beta-Endorphin; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Opioid Peptides; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Mimics of the binding sites of opioid receptors obtained by molecular imprinting of enkephalin and morphine.
Topics: alpha-Endorphin; Amino Acid Sequence; Binding Sites; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Morphine; Oligopeptides; Receptors, Opioid | 1995 |
Distribution of extrinsic enkephalin-containing nerve fibers in the rat rectum and their origin in the major pelvic ganglion.
Topics: Animals; Colchicine; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Fluorescent Dyes; Ganglia, Autonomic; Hirschsprung Disease; Immunohistochemistry; Male; Nerve Fibers; Neural Pathways; Rats; Rectum; Stilbamidines; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1994 |
Hyperpolarization by opioids acting on mu-receptors of a sub-population of rat periaqueductal gray neurones in vitro.
Topics: Amino Acid Sequence; Analgesics; Animals; Cell Polarity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Lysine; Male; Membrane Potentials; Molecular Sequence Data; Narcotics; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Inhibition by opioids acting on mu-receptors of GABAergic and glutamatergic postsynaptic potentials in single rat periaqueductal gray neurones in vitro.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Molecular Sequence Data; Narcotics; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Receptors, GABA-A; Receptors, Opioid, mu; Synapses | 1994 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Immunocytochemical evidence for the presence of Met-enkephalin and Leu-enkephalin in distinct neurons in the brain of the elasmobranch fish Scyliorhinus canicula.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Dogfish; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hypothalamus; Immunohistochemistry; Male; Molecular Sequence Data; Neurons | 1994 |
Expression of the proenkephalin A gene and [Met5]-enkephalin secretion induced by arachidonic acid in bovine adrenal medullary chromaffin cells: involvement of second messengers.
Topics: Adrenal Medulla; Animals; Arachidonic Acid; Base Sequence; Calcium Channel Blockers; Calmodulin; Cattle; Cells, Cultured; Chromaffin System; Colforsin; Enkephalin, Methionine; Enkephalins; Gene Expression; Imidazoles; Molecular Probes; Molecular Sequence Data; Protein Kinase C; Protein Precursors; RNA, Messenger; Second Messenger Systems; Sphingosine | 1995 |
Opposing activities of brain opioid receptors in the regulation of humoral and cell-mediated immune responses in the rat.
Topics: Analysis of Variance; Animals; Antibody Formation; Benzomorphans; Brain; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Hypersensitivity, Delayed; Immunity, Cellular; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Skin | 1994 |
Mesoaccumbens dopamine-opiate interactions in the control over behaviour by a conditioned reinforcer.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Dextroamphetamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Ergolines; Injections; Male; Nucleus Accumbens; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid; Tegmentum Mesencephali | 1994 |
Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Anesthesia, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Halothane; Heart Rate; Hot Temperature; Injections, Spinal; Male; Morphine; Nalbuphine; Nociceptors; Pain Threshold; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Reflex; Thiophenes | 1995 |
Effects of ACTH 1-24 on hydrolysis of beta-casomorphin-4-nitroanilide in brain homogenates in vivo and in vitro.
Topics: Animals; Brain Chemistry; Corticosterone; Cosyntropin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; Rats; Rats, Wistar | 1994 |
Preproenkephalin mRNA and methionine-enkephalin content are increased in mouse striatum after treatment with nicotine.
Topics: Animals; Brain; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Protein Precursors; RNA, Messenger; Tissue Distribution | 1995 |
Opioid actions on rat anterior cingulate cortex neurons in vitro.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glutamates; Glutamic Acid; Gyrus Cinguli; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Neurotransmitter Agents; Rats; Receptors, Opioid; Somatostatin; Synapses; Synaptic Transmission | 1994 |
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
Topics: Analysis of Variance; Animals; Antibodies; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclosporine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Inflammation; Injections; Interleukin-1; Male; Naloxone; Pain; Rats; Rats, Wistar; Recombinant Proteins; Regression Analysis; Somatostatin | 1994 |
Facilitation of self-stimulation of ventral tegmentum by microinjection of opioid receptor subtype agonists.
Topics: Analgesics; Animals; Brain Mapping; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Hypothalamic Area, Lateral; Male; Medial Forebrain Bundle; Motivation; Naloxone; Neural Pathways; Rats; Rats, Wistar; Receptors, Opioid; Self Stimulation; Substantia Nigra; Tegmentum Mesencephali; Ventral Tegmental Area | 1994 |
Effect of peptidases at the blood brain barrier on the permeability of enkephalin.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Cattle; CD13 Antigens; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Molecular Sequence Data; Neprilysin; Peptidyl-Dipeptidase A | 1994 |
Synaptic vesicle proteins and target-dependent morphogenesis of calyx-like contacts in vitro.
Topics: Animals; Cells, Cultured; Chickens; Enkephalin, Methionine; Enkephalins; Ganglia, Sympathetic; Immunohistochemistry; Intercellular Junctions; Morphogenesis; Neurons; Synaptic Vesicles | 1994 |
Relative survival of striatal projection neurons and interneurons after intrastriatal injection of quinolinic acid in rats.
Topics: Animals; Antibodies; Cell Survival; Choline O-Acetyltransferase; Corpus Striatum; Efferent Pathways; Enkephalin, Leucine; Enkephalin, Methionine; Globus Pallidus; Huntington Disease; Immunohistochemistry; Interneurons; Male; Microinjections; Nerve Fibers; Neurons; Neuropeptide Y; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Somatostatin | 1994 |
Expression of preproenkephalin A gene and presence of Met-enkephalin in dorsal root ganglia of the adult rat.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcitonin Gene-Related Peptide; DNA Primers; DNA, Complementary; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Gene Expression; In Situ Hybridization; Male; Molecular Sequence Data; Polymerase Chain Reaction; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Effects of nicotine on the concentration of native and cryptic Met- and Leu-enkephalin in peripheral tissues.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Male; Nicotine; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1994 |
Capillary zone electrophoresis of peptides: prediction of the electrophoretic mobility and resolution.
Topics: Amino Acid Sequence; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Indicators and Reagents; Molecular Sequence Data; Peptides | 1994 |
Increase in enkephalin-like immunoreactivity in hippocampi of adults with generalized epilepsy.
Topics: Adult; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epilepsy, Generalized; Female; Hippocampus; Humans; Immunohistochemistry; Male; Middle Aged; Neuronal Plasticity | 1994 |
Peripheral opioid systems in cluster headache.
Topics: beta-Endorphin; Cluster Headache; Enkephalin, Methionine; Enkephalins; Humans; Neutrophils; Protein Precursors; Receptors, Opioid; Reference Values; Sympathetic Nervous System | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Difference between plasma N- and C-terminally directed beta-endorphin immunoreactivity in infantile autism.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Autistic Disorder; beta-Endorphin; Child; Child, Preschool; Dopamine; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Female; Humans; Male; Norepinephrine; Opioid Peptides; Peptide Termination Factors; Pro-Opiomelanocortin; Radioimmunoassay; Rett Syndrome | 1994 |
Ultrastructural evidence for synaptic inputs of enkephalinergic nerve terminals to target neurons in the rat arcuate nucleus.
Topics: 3,3'-Diaminobenzidine; Animals; Arcuate Nucleus of Hypothalamus; Benzidines; beta-Endorphin; Chromogenic Compounds; Enkephalin, Methionine; Enkephalins; Male; Microscopy, Immunoelectron; Neurons; Neuropeptide Y; Presynaptic Terminals; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 1994 |
Opioid effects of short enkephalin fragments containing the Gly-Phe sequence on contractile responses of guinea pig ileum.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Peptide Fragments | 1994 |
Opioid peptides, adrenocorticotrophic hormone, and idiopathic (orthostatic) edema.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; beta-Endorphin; Blood Urea Nitrogen; Body Weight; Dextroamphetamine; Dopamine; Edema; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Hypotension, Orthostatic; Middle Aged; Renin; Sodium; Spironolactone; Syndrome; Vasopressins | 1994 |
Characterization of a metalloprotease from ovine chromaffin granules which cleaves a proenkephalin fragment (BAM12P) at a single arginine residue.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Arginine; Cations, Divalent; Chromaffin Granules; Chromatography; Copper; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Isoelectric Point; Metalloendopeptidases; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Protein Precursors; Sheep; Zinc | 1994 |
Alterations in hypothalamic mu-opiate receptor-mediated responses but not methionine enkephalin or proenkephalin messenger RNA levels in rats with acute cholestasis.
Topics: Acute Disease; Animals; Cholestasis; Corticotropin-Releasing Hormone; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Hypothalamus; Male; Pituitary Gland; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger | 1994 |
Dynamics of Met5- and Leu5-enkephalin and their receptor binding activity in relation to morphine.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Models, Molecular; Morphine; Receptors, Opioid | 1994 |
Aging, cardiac proenkephalin mRNA and enkephalin peptides in the Fisher 344 rat.
Topics: Aging; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Myocardium; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Sympathectomy, Chemical | 1994 |
Ontogeny of the proenkephalin system in the rat corpus striatum: its relationship to dopaminergic innervation and transient compartmental expression.
Topics: Aging; Animals; Corpus Striatum; DNA Probes; Dopamine; Embryo, Mammalian; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Gestational Age; Immunohistochemistry; In Situ Hybridization; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 1993 |
Effects of efferent neurotransmitters on intracellular Ca2+ concentration in vestibular hair cells of the guinea pig.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Axons; Calcitonin Gene-Related Peptide; Calcium; Dendrites; Efferent Pathways; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Guinea Pigs; Hair Cells, Auditory; Microscopy, Fluorescence; Neurotransmitter Agents; Synapses; Synaptic Transmission; Vestibular Nerve; Vestibule, Labyrinth | 1993 |
Trophic factor production by reactive astrocytes in injured brain.
Topics: Aging; Animals; Astrocytes; Biomarkers; Cells, Cultured; Cerebellum; Enkephalin, Methionine; Enkephalins; Fetus; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Growth Factors; Neuropeptides; Neurotoxins; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin | 1993 |
Endogenous opioid regulation of oxytocin secretion through pregnancy in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Pregnancy; Pregnancy, Animal; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Vasopressins | 1993 |
Opioid actions on neurons of rat lateral amygdala in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Amino Acids; Amygdala; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; GABA-A Receptor Antagonists; In Vitro Techniques; Molecular Sequence Data; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pyrrolidines; Rats; Somatostatin; Synapses | 1993 |
Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Benzomorphans; beta-Endorphin; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Pain Measurement; Pyrrolidines; Spinal Cord; Time Factors | 1993 |
Patterns of enkephalin immunolabeling in the pulmonate snail Cepaea nemoralis and related molluscs.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; FMRFamide; Immunohistochemistry; Mollusca; Nervous System; Neuropeptides; Neurotransmitter Agents; Serotonin; Snails; Tissue Distribution | 1993 |
Dynorphin modulates prolactin secretion in the turkey.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Prolactin; Protein Precursors; Turkeys | 1993 |
Immunocytochemical localization of the neuropeptide-synthesizing enzyme PC1 in AtT-20 cells.
Topics: Animals; Aspartic Acid Endopeptidases; Brefeldin A; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum; Enkephalin, Methionine; Enkephalins; Golgi Apparatus; Immunohistochemistry; Mice; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Protein Synthesis Inhibitors | 1993 |
Met-enkephalin-Arg6-Gly7-Leu8-like immunoreactivity in mammalian taste buds.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Immunohistochemistry; Male; Mice; Phosphopyruvate Hydratase; Protein Precursors; Rats; Taste Buds | 1993 |
Adrenal secretion of BAM-22P, a potent opioid peptide, is enhanced in rats with acute cholestasis.
Topics: Acute Disease; Adrenal Glands; Adrenalectomy; Animals; Cholestasis; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Preproenkephalin mRNA expression in the developing and adult rat brain.
Topics: Aging; Animals; Blotting, Northern; Brain; Cerebellum; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Female; Gene Expression; Gestational Age; In Situ Hybridization; Male; Organ Specificity; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Improved clean-up method for the enkephalins in plasma using immunoaffinity chromatography.
Topics: Amino Acid Sequence; Antibodies; Binding Sites; Chromatography, Affinity; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Molecular Sequence Data; Spectrometry, Fluorescence | 1994 |
QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons.
Topics: Anesthetics, Local; Animals; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Lidocaine; Locus Coeruleus; Narcotic Antagonists; Neural Conduction; Neurons; Potassium Channels; Rats; Receptors, Opioid; Sodium Channels | 1994 |
Human brain methionine- and leucine-enkephalins and their receptors during ageing.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Brain; Child; Child, Preschool; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Radioimmunoassay; Receptors, Opioid | 1993 |
Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord | 1993 |
Opioid peptide release evoked by noxious stimulation of the hind instep of rats.
Topics: Animals; beta-Endorphin; Chromatography, High Pressure Liquid; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Hindlimb; Hot Temperature; Male; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 1993 |
Chromatographic analysis of the enkephalin immunoreactivity in the nucleus locus coeruleus of the cat after local colchicine administration.
Topics: Animals; Cats; Chromatography, High Pressure Liquid; Colchicine; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; Locus Coeruleus; Radioimmunoassay | 1993 |
Assay of preproenkephalin A processing enzymes in human lumbar cerebrospinal fluid.
Topics: Amino Acid Sequence; Animals; Cattle; Endopeptidases; Enkephalin, Methionine; Enkephalins; Humans; Kinetics; Lumbosacral Region; Molecular Sequence Data; Peptide Fragments; Protein Precursors | 1993 |
Fetal adrenalectomy does not affect circulating enkephalins in the sheep fetus during late gestation.
Topics: Adrenal Glands; Adrenalectomy; Animals; Enkephalin, Methionine; Enkephalins; Female; Femoral Artery; Fetal Blood; Fetus; Gestational Age; Norepinephrine; Pregnancy; Sheep; Umbilical Veins | 1993 |
Age-associated increase in rat cardiac opioid production.
Topics: Aging; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Hypertrophy, Left Ventricular; Male; Myocardium; Osmolar Concentration; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sympathectomy, Chemical | 1993 |
[Some features of enkephalin metabolism in the rat brain after administration of bestatin].
Topics: Aminopeptidases; Animals; Brain; Carboxypeptidase H; Carboxypeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Neprilysin; Rats | 1993 |
Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.
Topics: Amino Acid Sequence; Analgesics; Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Enkephalin, Methionine; Enkephalins; Male; Mice; Mice, Inbred Strains; Models, Biological; Molecular Sequence Data; Predictive Value of Tests | 1993 |
Immunomodulation of human T cell responses with receptor selective enkephalins.
Topics: Adjuvants, Immunologic; Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; In Vitro Techniques; Leprosy; Lymphocyte Activation; Molecular Sequence Data; Opioid Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Receptors, Opioid, mu; Rosette Formation; T-Lymphocytes; Tuberculosis, Pulmonary | 1993 |
Schistosoma mansoni: an enkephalinergic system that may participate in internal and host-parasite signaling.
Topics: Animals; beta-Endorphin; Binding, Competitive; Biomphalaria; Cell Communication; Cricetinae; Enkephalin, Methionine; Enkephalins; Host-Parasite Interactions; Naloxone; Radioimmunoassay; Receptors, Opioid; Schistosoma mansoni; Signal Transduction; Trypsin; Trypsin Inhibitors | 1993 |
Oxytocin nerve terminal desensitization to kappa-opioids at the end of pregnancy.
Topics: Animals; Benzomorphans; Drug Resistance; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Nerve Endings; Oxytocin; Pituitary Gland, Posterior; Pregnancy; Pregnancy, Animal; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reference Values; RNA, Messenger; Supraoptic Nucleus | 1993 |
[The effect of endogenous enkephalins on the phenomenon of the synchronization of vagus and cardiac rhythms].
Topics: Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Heart Rate; Vagus Nerve | 1993 |
Immunodetection of endogenous opioid peptides in human brain tumors and associated cyst fluids.
Topics: Brain Neoplasms; Cysts; Enkephalin, Methionine; Enkephalins; Glial Fibrillary Acidic Protein; Glioma; Humans; Immunohistochemistry; Protein Precursors; Radioimmunoassay | 1993 |
Met-enkephalin secretion from mixed cultures of hypothalamic neurons and astrocytes.
Topics: Animals; Astrocytes; Cell Division; Cells, Cultured; Cytarabine; Enkephalin, Methionine; Enkephalins; Hypothalamus; Neurons; Protein Precursors; Radioimmunoassay | 1993 |
Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens.
Topics: Analgesics; Animals; Anticonvulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Naltrexone; Oligopeptides; Pyrroles; Receptors, Opioid, delta; Thiophenes; Vas Deferens | 1993 |
Developmental changes in rat adrenal enkephalin precursor: peptide ratio.
Topics: Adrenal Glands; Aging; Animals; Carboxypeptidase H; Carboxypeptidases; Enkephalin, Methionine; Enkephalins; Nicotine; Protein Precursors; Rats; Rats, Inbred F344 | 1993 |
Secretion of a neuropeptide-metabolizing enzyme similar to endopeptidase 22.19 by glioma C6 cells.
Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Glioma; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Neuropeptides; Rats; Sequence Homology, Amino Acid; Substrate Specificity; Tumor Cells, Cultured | 1993 |
Deletions of the synenkephalin domain which do not alter cell-specific proteolytic processing or secretory targeting of human proenkephalin.
Topics: Animals; DNA; Endopeptidases; Enkephalin, Methionine; Enkephalins; Gene Expression; Humans; Mice; Molecular Weight; Pituitary Neoplasms; Plasmids; Prolactin; Protein Precursors; Rats; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured | 1993 |
Effects of met-enkephalin on GABAergic spontaneous miniature IPSPs in organotypic slice cultures of the rat hippocampus.
Topics: Animals; Cadmium; Calcium; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Extracellular Space; gamma-Aminobutyric Acid; Hippocampus; Magnesium; Organ Culture Techniques; Osmolar Concentration; Potassium; Rats; Synapses | 1993 |
In vivo modulation of gastrointestinal motor activity by Met-enkephalin, morphine and enkephalin analogs in chickens.
Topics: Amino Acid Sequence; Animals; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Immunohistochemistry; Male; Molecular Sequence Data; Morphine; Motor Activity; Naloxone; Nerve Fibers; Vagotomy; Vagus Nerve | 1993 |
Dopamine decreases striatal enkephalin turnover and proenkephalin messenger RNA abundance via D2 receptor activation in primary striatal cell cultures.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blotting, Northern; Bromocriptine; Cells, Cultured; Corpus Striatum; Dopamine; Dopamine Antagonists; Enkephalin, Methionine; Enkephalins; Female; Potassium Chloride; Pregnancy; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Sulpiride | 1993 |
[Role of opioid peptide in rheumatoid arthritis--detection of methionine-enkephalin and leucine-enkephalin in synovial tissue].
Topics: Adult; Arthritis, Rheumatoid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Middle Aged; Synovial Membrane | 1993 |
Long-term stimulation of nicotinic receptors is required to increase proenkephalin A mRNA levels and the delayed secretion of [Met5]-enkephalin in bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cholinergic Antagonists; DNA Probes; Enkephalin, Methionine; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Isoquinolines; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Nimodipine; Piperazines; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1995 |
Opioid and tachykinin neuropeptides in prolactin-secreting human pituitary adenomas.
Topics: Adenoma; Adult; Aged; Amino Acid Sequence; beta-Endorphin; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Female; Humans; Immunohistochemistry; In Vitro Techniques; Male; Mass Spectrometry; Middle Aged; Molecular Sequence Data; Opioid Peptides; Pituitary Gland; Pituitary Neoplasms; Pro-Opiomelanocortin; Prolactin; Protein Precursors; Substance P; Tachykinins | 1995 |
Penicillin-G induced interictal activity increases both opioid peptide tissue content and in vitro release in the rat brain.
Topics: Amino Acid Sequence; Amygdala; Animals; Brain; Convulsants; Enkephalin, Leucine; Enkephalin, Methionine; Evoked Potentials; In Vitro Techniques; Male; Molecular Sequence Data; Penicillin G; Rats; Rats, Wistar; Time Factors | 1995 |
Effect of Met-enkephalin and opioid antagonists on rat macrophages.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hydrogen Peroxide; Infant, Newborn; Macrophages; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1995 |
Anatomical basis for interactions of enkephalins with other transmitters in the CNS of a snail.
Topics: Animals; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; FMRFamide; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Immunohistochemistry; Neuropeptides; Neurotransmitter Agents; Serotonin; Snails; Tyrosine 3-Monooxygenase | 1995 |
Effects of unilateral 6-hydroxydopamine lesions on neuropeptide immunoreactivity in the basal ganglia of the common marmoset, Callithrix jacchus, a quantitative immunohistochemical analysis.
Topics: Animals; Basal Ganglia; Behavior, Animal; Callithrix; Dopamine; Dopamine Agents; Enkephalin, Methionine; Enkephalins; Immunohistochemistry; MPTP Poisoning; Neostriatum; Neuropeptides; Oxidopamine; Substance P; Sympatholytics; Tyrosine 3-Monooxygenase | 1995 |
Opioid peptides in the nervous system of Aplysia: a combined biochemical, immunocytochemical, and electrophysiological study.
Topics: Analgesics, Opioid; Animals; Aplysia; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ganglia, Invertebrate; Immunohistochemistry; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Organ Specificity; Patch-Clamp Techniques; Receptors, Opioid | 1995 |
Hemorrhage alters plasma and cardiac enkephalins and catecholamines in anesthetized dogs.
Topics: Animals; Catecholamines; Chromatography; Dogs; Enkephalin, Methionine; Enkephalins; Hemorrhage; Hypotension; Myocardium; Peptides; Protein Precursors | 1995 |
[Bile-separating function under the action of enkephalins].
Topics: Animals; Bile Acids and Salts; Cholagogues and Choleretics; Enkephalin, Leucine; Enkephalin, Methionine; Liver; Male; Rats | 1995 |
Phosphorylation of enkephalins enhances their proteolytic stability.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kidney; Kinetics; Methionyl Aminopeptidases; Microsomes; Molecular Sequence Data; Phosphorylation; Substrate Specificity; Swine | 1996 |
Endogenous opioid peptides in parasympathetic, sympathetic and sensory nerves in the guinea-pig heart.
Topics: Adrenergic Fibers; Animals; Antibody Specificity; Axons; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Ganglia, Autonomic; Guinea Pigs; Heart; Immunohistochemistry; Male; Neurons, Afferent; Opioid Peptides; Parasympathetic Fibers, Postganglionic; Protein Precursors | 1996 |
Relationship between opioids and prostaglandins in hypoxia-induced vasodilation of pial arteries in the newborn pig.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Arterioles; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Dinoprostone; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hyperemia; Hypoxia, Brain; Indomethacin; Male; Oxygen; Partial Pressure; Pia Mater; Skin Window Technique; Swine; Vasodilation | 1996 |
Biochemical evidence of functional interaction between mu- and delta-opioid receptors in SK-N-BE neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Membrane Proteins; Neuroblastoma; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors; Tumor Cells, Cultured | 1996 |
Effect of NAD(P)H:quinone oxidoreductase on tyrosinase-mediated oxidation of opioid neuropeptides Leu-enkephalin and Met-enkephalin.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Glycine max; Monophenol Monooxygenase; NAD; NADP; Oxidation-Reduction; Quinone Reductases | 1995 |
Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease.
Topics: Aged; Autopsy; Basal Ganglia; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Parkinson Disease | 1996 |
The Neuro-2a neuroblastoma cell line expresses [Met]-enkephalin and vasopressin mRNA and peptide.
Topics: Animals; Arginine Vasopressin; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Gene Expression; Immunohistochemistry; In Situ Hybridization; Mice; Neuroblastoma; Polymerase Chain Reaction; Proprotein Convertase 2; Protein Precursors; RNA-Directed DNA Polymerase; RNA, Messenger; Subtilisins; Tumor Cells, Cultured; Vasopressins | 1995 |
The effects of delta-opioid receptor agonists on synaptic transmission in hamster submandibular ganglion.
Topics: Animals; Autonomic Fibers, Preganglionic; Cricetinae; Dimethylphenylpiperazinium Iodide; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; Ganglionic Stimulants; Naloxone; Narcotic Antagonists; Presynaptic Terminals; Receptors, Opioid, delta; Submandibular Gland; Synaptic Transmission | 1995 |
Predatory aggression induced by hypothalamic stimulation: modulation by midbrain periaqueductal gray (PAG).
Topics: Aggression; Animals; Cats; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Microinjections; Periaqueductal Gray; Predatory Behavior; Rats; Reference Values; Statistics as Topic | 1995 |
Cat proenkephalin-A does not contain the opioid octapeptide.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Base Sequence; Cats; Cloning, Molecular; DNA Primers; DNA, Complementary; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Molecular Sequence Data; Opioid Peptides; Protein Precursors; RNA-Directed DNA Polymerase | 1996 |
State-dependent changes of brain endogenous opioids in mammalian hibernation.
Topics: Animals; beta-Endorphin; Brain; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hibernation; Male; Opioid Peptides; Radioimmunoassay; Sciuridae | 1996 |
Prenatal morphine exposure differentially alters expression of opioid peptides in striatum of newborns.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Brain; Corpus Striatum; Dynorphins; Enkephalin, Methionine; Enkephalins; Female; Frontal Lobe; Gene Expression; Hippocampus; Hypothalamus; Morphine; Multivariate Analysis; Organ Specificity; Pregnancy; Prenatal Exposure Delayed Effects; Protein Biosynthesis; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
[Effect of acupuncture on the contents of enkephalins in different brain regions of rats with traumatic shock].
Topics: Animals; Brain; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Male; Rats; Shock, Traumatic | 1995 |
Regulation of DNA synthesis of myocardial and epicardial cells in developing rat heart by [Met5]enkephalin.
Topics: Aging; Animals; Animals, Newborn; Cells, Cultured; DNA; Enkephalin, Methionine; Enkephalins; Female; Male; Myocardium; Pericardium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Tissue Distribution | 1996 |
Distribution of peptidergic nerve fibres in bullfrog lingual papillae demonstrated by a combination of double immunofluorescence labelling and a multiple dye filter.
Topics: Animals; Calcitonin Gene-Related Peptide; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique, Direct; Galanin; Nerve Fibers; Neuropeptide Y; Neuropeptides; Rana catesbeiana; Substance P; Tongue; Vasoactive Intestinal Peptide | 1996 |
Effect of 2,2,2-trifluoroethanol on capillary zone electrophoretic peptide separations.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Electrophoresis, Capillary; Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Molecular Sequence Data; Myoglobin; Peptide Fragments; Peptides; Trifluoroethanol | 1996 |
Relationship between vasopressin and opioids in hypoxia induced pial artery vasodilation.
Topics: Animals; Arginine Vasopressin; Cerebral Arteries; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Hormone Antagonists; Hypoxia; Male; Osmolar Concentration; Pia Mater; Radioimmunoassay; Vasodilation; Vasopressins | 1996 |
Gene-peptide relationships in the developing rat brain: the response of preproenkephalin mRNA and [Met5]-enkephalin to acute opioid antagonist (naltrexone) exposure.
Topics: Animals; Caudate Nucleus; Cerebellum; Enkephalin, Methionine; Enkephalins; Female; Male; Naltrexone; Narcotic Antagonists; Protein Precursors; Putamen; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1995 |
The effect of prolonged treatment with imipramine and electroconvulsive shock on the levels of endogenous enkephalins in the nucleus accumbens and the ventral tegmentum of the rat.
Topics: Animals; Antidepressive Agents, Tricyclic; Electroshock; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Imipramine; In Situ Hybridization; Male; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; Ribonucleases; RNA, Messenger; Ventral Tegmental Area | 1995 |
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1996 |
The mu-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a nonopioid receptor-mediated increase in K+ conductance of rat locus ceruleus neurons.
Topics: Animals; Brimonidine Tartrate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Locus Coeruleus; Male; Naloxone; Narcotics; Neurons; Nociceptin; Opioid Peptides; Peptide Fragments; Peptides; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 1996 |
Substance P-induced respiratory excitation is blunted by delta-receptor specific opioids in the rat medulla oblongata.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Injections; Medulla Oblongata; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Respiratory Mechanics; Substance P | 1996 |
[Cys(O2NH2)2]enkephalin analogues and dalargin: selectivity for delta-opioid receptors.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Norepinephrine; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1996 |
The role of the pituitary-thyroid axis in the developmental regulation of enkephalin-containing peptides in the superior cervical ganglia and adrenal of the fetal sheep.
Topics: Adrenal Glands; Animals; Enkephalin, Methionine; Enkephalins; Female; Gestational Age; Hydrolysis; Hypophysectomy; Pituitary Gland; Pregnancy; Sheep; Superior Cervical Ganglion; Thyroid Gland | 1996 |
Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro.
Topics: Analgesics; Animals; Baclofen; Brain; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Fluorescent Dyes; GABA Agonists; In Vitro Techniques; Microspheres; Narcotics; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Rhodamines | 1996 |
Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Colon; Enkephalin, Leucine; Enkephalin, Methionine; Ganglia; Guinea Pigs; In Vitro Techniques; Magnesium; Male; Mesentery; Nerve Endings; Neurotensin; Peptide Fragments; Potassium | 1996 |
Influence of opioid peptides on the priming action of estrogen on lordosis in ovariectomized rats.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Estrogens; Female; Injections, Intraventricular; Male; Opioid Peptides; Ovariectomy; Posture; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal | 1996 |
Endogenous opioids in frontal cortex of patients with Down syndrome.
Topics: Aged; Alzheimer Disease; Down Syndrome; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Frontal Lobe; Gene Expression Regulation; Humans; Male; Middle Aged; Protein Precursors; Radioimmunoassay | 1996 |
The relevance of intact enkephalin molecule in predominantly delta opioid receptor mediated superoxide anion release.
Topics: Adult; Anions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Neprilysin; Neutrophils; Oligopeptides; Protease Inhibitors; Receptors, Opioid, delta; Superoxides; Thiorphan | 1995 |
Functional analysis of opioid receptor subtypes in the ventromedial hypothalamic nucleus of the rat.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Ventromedial Hypothalamic Nucleus | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
N-methyl-D-aspartate acutely increases proenkephalin mRNA in the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Excitatory Amino Acid Antagonists; Histocytochemistry; In Situ Hybridization; Injections, Intraventricular; Male; N-Methylaspartate; Prosencephalon; Protein Precursors; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 1995 |
Effect of low and high doses of nitrous oxide on preproenkephalin mRNA and its peptide methionine enkephalin levels in the hypothalamus.
Topics: Animals; Blotting, Northern; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Nitrous Oxide; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1996 |
Dexamethasone and forskolin synergistically increase [Met5]enkephalin accumulation in mixed brain cell cultures.
Topics: Animals; Astrocytes; Brain; Cells, Cultured; Colforsin; Dexamethasone; Drug Combinations; Drug Synergism; Enkephalin, Methionine; Enkephalins; Glucocorticoids; Neuroglia; Neurons; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Glucocorticoid; RNA, Messenger | 1996 |
Genotypic differences in mesolimbic enkephalin gene expression in DBA/2J and C57BL/6J inbred mice.
Topics: Alcohol Drinking; Animals; Blotting, Northern; Bromocriptine; Dopamine Agonists; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Genotype; Limbic System; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Radioimmunoassay; Receptors, Dopamine D2; RNA, Messenger; Species Specificity | 1996 |
Exposure to perinatal morphine promotes developmental changes in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Enkephalin, Methionine; Enkephalins; Female; In Situ Hybridization; Lactation; Male; Morphine; Narcotics; Neostriatum; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Serotonin; Substance P; Synapses; Synapsins; Time Factors; Tyrosine 3-Monooxygenase | 1996 |
Metabolism of enkephalins in head membranes of the leech Theromyzon tessulatum by peptidases: isolation of an enkephalin-degrading aminopeptidase.
Topics: Aminopeptidases; Animals; Binding Sites; Chromatography, High Pressure Liquid; Detergents; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hydrolysis; Kinetics; Leeches; Octoxynol; Polyethylene Glycols | 1996 |
Met-enkephalin inhibits 5-hydroxytryptamine release from the rat ventral spinal cord via delta opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Serotonin; Spinal Cord | 1996 |
The distribution of Met-enkephalin like immunoreactivity in the brain of Apteronotus leptorhynchus, with emphasis on the electrosensory system.
Topics: Animals; Brain Chemistry; Diencephalon; Electric Fish; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Mesencephalon; Neurons; Rhombencephalon; Telencephalon; Tissue Distribution | 1996 |
Processing site blockade results in more efficient conversion of proenkephalin to active opioid peptides.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA Primers; Enkephalin, Methionine; Enkephalins; Mice; Mutagenesis, Site-Directed; Pituitary Neoplasms; Point Mutation; Protein Precursors; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Transfection | 1996 |
Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1996 |
[Enkephalin participation in the regulatory pattern of the vagus influence on cardiac rhythm in cats during the volley stimulation of the vagus nerve].
Topics: Animals; Cats; Depression, Chemical; Electric Stimulation; Electrocardiography; Enkephalin, Methionine; Enkephalins; Female; Heart Rate; Male; Vagus Nerve | 1996 |
Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation.
Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Arteries; Blood Pressure; Cyclic AMP; Cyclic GMP; Enkephalin, Leucine; Enkephalin, Methionine; Female; Glyburide; Hypoxia; Male; Nitric Oxide; Nucleotides, Cyclic; Pia Mater; Potassium Channels; Swine; Theophylline; Vasodilation; Vasodilator Agents | 1997 |
Endothelin production links superoxide generation to altered opioid-induced pial artery vasodilation after brain injury in pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arterioles; Brain Injuries; Cerebral Arteries; Dynorphins; Endothelin Receptor Antagonists; Endothelin-1; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Muscle, Smooth, Vascular; Peptides, Cyclic; Pia Mater; Superoxides; Swine; Vasoconstriction; Vasodilation | 1997 |
Determination of peptide dissociation constants and Stokes radius at different protonation stages by capillary electrophoresis.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Bradykinin; Chemical Phenomena; Chemistry, Physical; Electrophoresis, Capillary; Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Mathematics; Peptide Fragments; Peptides; Protons | 1996 |
Ultralow concentrations of proenkephalin and [met5]-enkephalin differentially affect IgM and IgG production by B cells.
Topics: Animals; B-Lymphocytes; Cell Division; Dextran Sulfate; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Female; Immunoglobulin G; Immunoglobulin M; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Osmolar Concentration; Protein Precursors | 1997 |
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analgesics; Animals; beta-Endorphin; Clonidine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Interleukin-6; Isoproterenol; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Narcotic Antagonists; Neurons; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid; Spleen | 1997 |
Role of PACAP in the relationship between cAMP and opioids in hypoxia-induced pial artery vasodilation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Hypoxia, Brain; Male; Neuropeptides; Neurotransmitter Agents; Nitroprusside; Oxygen; Pia Mater; Pituitary Adenylate Cyclase-Activating Polypeptide; Swine; Vasodilation | 1997 |
Evidence for localized and discrete roles for enkephalins during memory formation in the chick.
Topics: Age Factors; Animals; Appetitive Behavior; Avoidance Learning; Brain; Brain Mapping; Chickens; Conditioning, Classical; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Mental Recall; Neuronal Plasticity; Taste | 1997 |
Determination of peptides by high-performance liquid chromatography with laser-induced fluorescence detection.
Topics: 4-Chloro-7-nitrobenzofurazan; Acetonitriles; Amino Acid Sequence; Animals; Bradykinin; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Hypothalamus; Male; Peptides; Rats; Spectrometry, Fluorescence | 1997 |
The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. 1977.
Topics: Animals; Biological Assay; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; History, 20th Century; Ileum; Mice; Pituitary Gland; Rabbits; Rats; Tissue Distribution | 1997 |
Role of midbrain ventro-lateral tegmental area (VTA) enkephalinergic mechanisms in the facilitation of hypothalamically-induced predatory attack behaviour.
Topics: Animals; Cats; Drug Interactions; Electric Stimulation; Electrodes, Implanted; Enkephalin, Methionine; Enkephalins; Female; Hypothalamus; Male; Microinjections; Naloxone; Narcotic Antagonists; Predatory Behavior; Rats; Staining and Labeling; Ventral Tegmental Area | 1997 |
Ethanol alters the concentration of Met-enkephalin in brain by affecting peptide transport system-1 independent of preproenkephalin mRNA.
Topics: Animals; Biological Transport; Enkephalin, Methionine; Enkephalins; Ethanol; Male; Mice; Mice, Inbred ICR; Neuropeptides; Osmolar Concentration; Protein Precursors; RNA, Messenger | 1997 |
Efficacy and kinetics of opioid action on acutely dissociated neurons.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines | 1997 |
Quantitative analysis of two opioid peptides in plasma by liquid chromatography-electrospray ionization tandem mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Mass Spectrometry; Rats; Sensitivity and Specificity | 1997 |
Enzymatic inactivation of enkephalin neurotransmitters in the spinal cord of the neonatal rat.
Topics: Animals; Animals, Newborn; Electric Stimulation; Electrophysiology; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Membrane Potentials; Naloxone; Narcotic Antagonists; Neprilysin; Neurotransmitter Agents; Protease Inhibitors; Rats; Spinal Cord; Spinal Nerve Roots; Synaptic Membranes | 1997 |
The effects of met-enkephaline, leu-enkephaline and tuftsine on guinea pig peritoneal granulocyte functions in vitro.
Topics: Animals; Ascitic Fluid; Enkephalin, Leucine; Enkephalin, Methionine; Granulocytes; Guinea Pigs; In Vitro Techniques; Tuftsin | 1996 |
[Met5]enkephalin and delta2-opioid receptors in the spinal cord are involved in the cold water swimming-induced antinociception in the mouse.
Topics: Animals; beta-Endorphin; Cold Temperature; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1997 |
Quantification of biomolecules by external electrospray ionization Fourier transform mass spectrometry.
Topics: Chromatography, Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Fourier Analysis; Mass Spectrometry; Muramidase; Reproducibility of Results | 1997 |
Differences in the hydrolysis of enkephalin congeners by the two domains of angiotensin converting enzyme.
Topics: Analgesics, Opioid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Kinetics; Peptidyl-Dipeptidase A | 1997 |
Stimulatory effect of intracerebroventricular met- and leu-enkephalin on corticosterone secretion in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Ventricles; Corticosterone; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Adrenergic; Yohimbine | 1996 |
Neuropeptide-containing nerve fibres in the human parotid gland: a semiquantitative analysis using an antibody against protein gene product 9.5.
Topics: Adult; Aged; Aged, 80 and over; Calcitonin Gene-Related Peptide; Enkephalin, Leucine; Enkephalin, Methionine; Female; FMRFamide; Galanin; Humans; Male; Middle Aged; Nerve Fibers; Nerve Tissue Proteins; Neuropeptide Y; Neuropeptides; Parotid Gland; Somatostatin; Substance P; Thiolester Hydrolases; Ubiquitin Thiolesterase; Vasoactive Intestinal Peptide | 1997 |
[Met]enkephalin in the spinal cord is involved in the antinociception induced by intracerebroventricularly-administered etorphine in the mouse.
Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Etorphine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain Measurement; Receptors, Opioid, delta; Receptors, sigma; Spinal Cord | 1997 |
Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice.
Topics: Analgesics, Opioid; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Mice; Mice, Knockout; Morphine; Neprilysin; Pain Threshold; Phenotype; Temperature | 1997 |
T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells.
Topics: Cells, Cultured; Culture Media; Cyclic AMP; Cytokines; Drug Synergism; Enkephalin, Methionine; Enkephalins; Humans; Immunohistochemistry; Interleukin-10; Interleukin-4; Monocytes; Polymerase Chain Reaction; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1997 |
[Effect of intrahippocampal microinjection of enkephalin on cellular immune function and brain IL-1 alpha gene expression in rat].
Topics: Adrenalectomy; Animals; Cell Division; Enkephalin, Leucine; Enkephalin, Methionine; Female; Gene Expression; Hippocampus; Interleukin-1; Male; Microinjections; Rats; Rats, Wistar; T-Lymphocytes | 1996 |
Differential effects of beta-endorphin and Met- and Leu-enkephalin on steroid hormone-induced lordosis in ovariectomized female rats.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Female; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Ovariectomy; Posture; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Steroids | 1997 |
Enkephalin, PPE mRNA, and PTS-1 in alcohol withdrawal seizure-prone and -resistant mice.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Ethanol; Female; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Protein Precursors; RNA, Messenger; Seizures; Substance Withdrawal Syndrome | 1998 |
Action of FMRFamide-like peptides on porcine gastrointestinal motility in vitro.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Enkephalin, Leucine; Enkephalin, Methionine; FMRFamide; Gastrointestinal Motility; Histamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neuropeptides; Nifedipine; Nitroprusside; Oligopeptides; Swine | 1997 |
Enkephalins modulate differentiation of normal human keratinocytes in vitro.
Topics: beta-Endorphin; Cell Differentiation; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Humans; Keratinocytes; Keratins; Melphalan; Naltrexone; Narcotic Antagonists; Skin; Transglutaminases | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Ontogeny of the opioid growth factor, [Met5]-enkephalin, preproenkephalin gene expression, and the zeta opioid receptor in the developing and adult aorta of rat.
Topics: Animals; Aorta; Enkephalin, Methionine; Enkephalins; Female; Immunohistochemistry; In Situ Hybridization; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Time Factors | 1998 |
In vivo assessment of opioid agonists and antagonists on ovarian maturation in the red swamp crayfish, Procambarus clarkii.
Topics: Animals; Astacoidea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Naloxone; Narcotic Antagonists; Ovary; Receptors, Opioid, delta | 1996 |
The autocrine derivation of the opioid growth factor, [Met5]-enkephalin, in ocular surface epithelium.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Epithelial Cells; Epithelium; Eye; Growth Substances; In Situ Hybridization; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA Probes; RNA, Messenger | 1998 |
Role of endogenous pro-enkephalin A-derived peptides in human T cell proliferation and monocyte IL-6 production.
Topics: Antibodies, Monoclonal; Cytokines; Enkephalin, Methionine; Enkephalins; Humans; Interleukin-6; Lipopolysaccharides; Monocytes; Oligonucleotides, Antisense; Oligopeptides; Peptides; Protein Precursors; T-Lymphocytes | 1998 |
Immunohistochemical investigation of enkephalins in the human inner ear.
Topics: Antibodies; Cochlea; Enkephalin, Leucine; Enkephalin, Methionine; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Humans; Immunohistochemistry; Microscopy, Electron; Octoxynol; Organ of Corti; Temporal Lobe; Tissue Fixation; Vestibule, Labyrinth | 1998 |
Immunocytochemical localization of enkephalins in the brain of the African lungfish, Protopterus annectens, provides evidence for differential distribution of Met-enkephalin and Leu-enkephalin.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Fishes; Immunohistochemistry; Nerve Fibers; Neurons; Organ Specificity; Vertebrates | 1998 |
The C-terminal tetrapeptide of beta-endorphin (MPF) enhances lymphocyte proliferative responses.
Topics: Animals; beta-Endorphin; Cell Division; Concanavalin A; Dipeptides; Dose-Response Relationship, Immunologic; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Glutamic Acid; Glycine; Humans; Lymphocyte Activation; Mitogens; Oligopeptides; Peptide Fragments; Rats; Species Specificity; T-Lymphocytes | 1998 |
Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.
Topics: Analgesics, Opioid; Antibody Specificity; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Enzyme Inhibitors; Indoles; Morphine; Neuroblastoma; Neurons; Phosphorylation; Precipitin Tests; Pyrroles; Receptors, Opioid, mu; Tumor Cells, Cultured | 1998 |
Elevated proenkephalin-derived peptide levels in ACTH-producing adenomas: nucleus and cytoplasm localization.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Aged; Carboxypeptidase B; Carboxypeptidases; Chromatography, Gel; Chromatography, High Pressure Liquid; Deoxyribonuclease I; Enkephalin, Methionine; Enkephalins; Female; Human Growth Hormone; Humans; In Vitro Techniques; Male; Middle Aged; Molecular Weight; Pituitary Gland; Pituitary Neoplasms; Protein Precursors; Protein Processing, Post-Translational; Trypsin | 1998 |
[Effect of enkephalins on the liver secretory function].
Topics: Animals; Bile; Bile Acids and Salts; Enkephalin, Leucine; Enkephalin, Methionine; Lipid Metabolism; Liver; Male; Proteins; Rats; Rats, Wistar | 1998 |
Sex differences in estrogenic regulation of preproenkephalin mRNA levels in the medial preoptic area of prepubertal rats.
Topics: Animals; Cell Size; Enkephalin, Methionine; Enkephalins; Estrogens; Female; Gene Expression Regulation, Developmental; In Situ Hybridization; Male; Neurons; Preoptic Area; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sex Characteristics; Sexual Maturation | 1998 |
Preproenkephalin gene expression and [Met5]-enkephalin levels in the developing rat heart.
Topics: Aging; Animals; Caudate Nucleus; DNA Probes; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Female; Fetal Heart; Gene Expression Regulation, Developmental; Gestational Age; Heart; Liver; Male; Myocardium; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1998 |
Long-term pharmacological kindling increases in vitro release of IR-Met and IR-Leu-enkephalin from amygdala.
Topics: Amygdala; Animals; Convulsants; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
PACAP activates calcium influx-dependent and -independent pathways to couple met-enkephalin secretion and biosynthesis in chromaffin cells.
Topics: Adrenal Glands; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Signaling; Cattle; Chromaffin Cells; Colforsin; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Male; Models, Biological; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium; Protein Precursors; Radioimmunoassay; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1998 |
Opioid receptor ligands in human hepatic encephalopathy.
Topics: beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Hepatic Encephalopathy; Humans; Ligands; Radioimmunoassay; Receptors, Opioid | 1998 |
Sexual behavior in male rats induces changes in brain enkephalins.
Topics: Animals; Brain; Ejaculation; Enkephalin, Leucine; Enkephalin, Methionine; Frontal Lobe; Hippocampus; Hypothalamus; Male; Mesencephalon; Rats; Rats, Wistar | 1998 |
Nitric oxide contributes to opioid release from glia during hypoxia.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Enkephalin, Leucine; Enkephalin, Methionine; Neuroglia; Nitric Oxide; Nitroprusside; Sulfhydryl Reagents; Swine | 1998 |
Vulnerability to stressor-induced disturbances in self-stimulation from the dorsal and ventral A10 area: differential effects of intraventricular D-Ala2-Met5-enkephalinamide, D-Ala2, N-Me-Phe4, Gly-Ol5-enkephalin, and D-Pen2, D-Pen5-enkephalin administrat
Topics: Animals; Electric Stimulation; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Foot; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu; Self Stimulation; Stress, Physiological; Tegmentum Mesencephali; Time Factors | 1998 |
5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by mu-opiate receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Models, Neurological; Neocortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptors, Opioid, mu; Receptors, Serotonin; Serotonin; Somatostatin; Synapses | 1998 |
Enkephalin receptors and receptor-mediated signal transduction in cultured human lymphocytes.
Topics: Calcium; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Lymphocytes; Naloxone; Receptors, Opioid; Signal Transduction | 1999 |
Effects of peptidase inhibitors, [D-Ala2, Met5]-enkephalinamide and antiserum to methionine-enkephalin microinjected into the caudal periaqueductal gray on morphine withdrawal in rats.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Immune Sera; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Periaqueductal Gray; Protease Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome | 1998 |
Enkephalin analogs containing 4,4-difluoro-2-aminobutyric acid: synthesis and fluorine effect on the biological activity.
Topics: Aminobutyrates; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fluorine; Guinea Pigs; Ileum; Male; Mice; Models, Chemical; Receptors, Opioid, delta; Vas Deferens | 1998 |
The role of aminopeptidase N in Met-enkephalin modulated superoxide anion release.
Topics: Adult; Analgesics; Analgesics, Opioid; CD13 Antigens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Leucine; Male; Neutrophils; Oligopeptides; Protease Inhibitors; Superoxides | 1999 |
The effect of chronic administration of nicotine on antinociception, opioid receptor binding and met-enkelphalin levels in rats.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hot Temperature; Male; Nicotine; Nicotinic Agonists; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Smoking; Tobacco Use Disorder; Tritium | 1999 |
Differential response to a stress stimulus of proenkephalin peptide content in immune cells of naive and chronically stressed rats.
Topics: Animals; Bone Marrow Cells; Electroshock; Enkephalin, Methionine; Enkephalins; Leukocytes, Mononuclear; Macrophages; Male; Protein Precursors; Rats; Rats, Wistar; Spleen; Stress, Physiological; Thymus Gland | 1998 |
Augmenting effect of opioids on nitrite production by stimulated murine macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitrites; Opioid Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Diurnal variations of opioid peptides and synenkephalin in vitro release in the amygdala of kindled rats.
Topics: Amygdala; Animals; Circadian Rhythm; Convulsants; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Injections, Intraperitoneal; Kindling, Neurologic; Male; Opioid Peptides; Pentylenetetrazole; Protein Precursors; Rats; Rats, Wistar | 1998 |
The hippocampal opioidergic system: a comparative immunocytochemical study in four rodents.
Topics: Animals; Cricetinae; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Guinea Pigs; Hippocampus; Immunohistochemistry; Male; Mesocricetus; Mice; Nerve Fibers; Neurons; Pyramidal Cells; Rats; Species Specificity | 1998 |
Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.
Topics: Animals; Biological Assay; Chemistry, Pharmaceutical; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Peptide Biosynthesis; Protein Binding; Protein Precursors; Receptors, Opioid, delta; Vas Deferens | 1999 |
The differential processing of proenkephalin A in mouse and human breast tumour cell lines.
Topics: Animals; Aspartic Acid Endopeptidases; Breast Neoplasms; Enkephalin, Methionine; Enkephalins; Female; Humans; Immunoblotting; Mammary Neoplasms, Animal; Mice; Proprotein Convertase 1; Proprotein Convertase 2; Proprotein Convertases; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Subtilisins; Tumor Cells, Cultured | 1999 |
Opioid peptides inhibit the action of oestradiol on human myometrial cells in culture.
Topics: Adult; Cell Division; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Estradiol; Female; Humans; Inhibitory Concentration 50; Muscle, Smooth; Myometrium; Naloxone; Narcotic Antagonists; Progesterone | 1999 |
Presynaptic mu and delta opioid receptor modulation of GABAA IPSCs in the rat globus pallidus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analgesics, Opioid; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Excitatory Amino Acid Antagonists; GABA Antagonists; Globus Pallidus; In Vitro Techniques; Male; Membrane Potentials; Neostriatum; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Synaptic Transmission; Tetrodotoxin | 1999 |
Nota bene: biomedicine. Pain-killer genes.
Topics: Animals; beta-Endorphin; Chronic Disease; Enkephalin, Methionine; Enkephalins; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Mice; Pain Management; Protein Precursors; Simplexvirus; Spinal Cord | 1999 |
Alpha1-antichymotrypsin-like proteins I and II purified from bovine adrenal medulla are enriched in chromaffin granules and inhibit the proenkephalin processing enzyme "prohormone thiol protease".
Topics: Adrenal Medulla; alpha 1-Antichymotrypsin; Animals; Cattle; Chromaffin Granules; Chymotrypsin; Cysteine Endopeptidases; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Isoelectric Point; Protein Precursors; Serine Proteinase Inhibitors | 1999 |
Enkephalin inhibits vagal control of heart rate, contractile force and coronary blood flow in the canine heart in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Coronary Circulation; Diprenorphine; Dogs; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Female; Heart Rate; Male; Myocardial Contraction; Narcotic Antagonists; Vagus Nerve | 1999 |
Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cell Fractionation; Cells, Cultured; Chromaffin Granules; Cysteine Endopeptidases; Enkephalin, Methionine; Enkephalins; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Microscopy, Electron; Microscopy, Immunoelectron; Protein Precursors; Protein Processing, Post-Translational | 1999 |
Opioid growth factor and organ development in rat and human embryos.
Topics: Animals; Brain; Brain Chemistry; DNA; Ectoderm; Embryonic and Fetal Development; Endoderm; Enkephalin, Methionine; Enkephalins; Female; Fetus; Gene Expression Regulation, Developmental; Heart; Humans; Immunohistochemistry; In Situ Hybridization; Intestines; Male; Mesoderm; Muscles; Myocardium; Naltrexone; Narcotic Antagonists; Pregnancy; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Ribs; RNA, Messenger; Skin; Tongue | 1999 |
Peptide transport system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Capillaries; Carrier Proteins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Iodine Radioisotopes; Male; Mice; Mice, Inbred ICR; MSH Release-Inhibiting Hormone; Receptors, Opioid; Thyrotropin-Releasing Hormone; Tyrosine | 1999 |
Electrospray ionization fourier transform mass spectrometry quantification of enkephalin using an internal standard.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Fourier Analysis; Mass Spectrometry; Reference Standards | 1999 |
Electrophysiological effects of opioid receptor activation on Syrian hamster suprachiasmatic nucleus neurones in vitro.
Topics: Action Potentials; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Cricetinae; Enkephalin, Leucine; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Suprachiasmatic Nucleus; Time Factors | 1999 |
Preproenkephalin is a Th2 cytokine but is not required for Th2 differentiation in vitro.
Topics: Animals; Cell Differentiation; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Flow Cytometry; Interleukin-4; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Protein Precursors; RNA, Messenger; Th1 Cells; Th2 Cells | 1999 |
Molecular cloning of endopin 1, a novel serpin localized to neurosecretory vesicles of chromaffin cells. Inhibition of basic residue-cleaving proteases by endopin 1.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Base Sequence; Cattle; Chromaffin Cells; Chromaffin Granules; Cloning, Molecular; Cysteine Endopeptidases; DNA, Complementary; Endopeptidases; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Gene Expression; Glycoproteins; Hydrolysis; Molecular Sequence Data; Neurosecretory Systems; Protease Inhibitors; Protein Precursors; Recombinant Fusion Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Serpins; Trypsin | 1999 |
Stimulatory effect of enkephalins on calcium efflux from bovine adrenal chromaffin cells in culture.
Topics: Adrenal Medulla; Animals; Calcium; Calcium Radioisotopes; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Cyclic AMP; Cyclic GMP; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fluorescent Dyes; Fura-2 | 1999 |
Met5-enkephalin protects isolated adult rabbit cardiomyocytes via delta-opioid receptors.
Topics: Animals; beta-Endorphin; Cell Hypoxia; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Ischemic Preconditioning; Male; Models, Cardiovascular; Morphine; Myocardial Ischemia; Myocardium; Naloxone; Rabbits; Rats; Receptors, Opioid, delta | 1999 |
Paraganglia of the gallbladder: a report of two cases with an immunohistochemical study.
Topics: Cholecystitis; Chromogranin A; Chromogranins; Chronic Disease; Dopamine beta-Hydroxylase; Enkephalin, Leucine; Enkephalin, Methionine; Female; Gallbladder; Humans; Immunoenzyme Techniques; Middle Aged; Paraganglia, Chromaffin; S100 Proteins; Tyrosine 3-Monooxygenase | 1999 |
Antisense peptide interactions studied by electrospray ionization mass spectrometry.
Topics: Antisense Elements (Genetics); Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mass Spectrometry; Peptides | 2000 |
Comparison of tyrosine hydroxylase and preproenkephalin expression in rat adrenal medullary explants in vitro and transplanted into subarachnoid space.
Topics: Adrenal Medulla; Animals; Catecholamines; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; In Situ Hybridization; In Vitro Techniques; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Subarachnoid Space; Tyrosine 3-Monooxygenase | 2000 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.
Topics: Analgesics, Opioid; Animals; Antimetabolites; Apoptosis; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Mice; Microscopy, Electron; Morphine; Naloxone; Narcotic Antagonists; Neurites; Neurons; Oligopeptides; Opioid-Related Disorders; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Stem Cells | 2000 |
Immunoneutralization of endogenous opioid peptides prevents the suckling-induced prolactin increase and the inhibition of tuberoinfundibular dopaminergic neurons.
Topics: Animals; Animals, Suckling; Arcuate Nucleus of Hypothalamus; Cross Reactions; Dopamine; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Immunoglobulin G; Lactation; Male; Neurons; Neutralization Tests; Opioid Peptides; Pituitary Gland; Prolactin; Rats; Rats, Sprague-Dawley | 2000 |
[Opioid system and cardiac resistance to ischemic and reperfusion injuries].
Topics: Animals; Creatine Kinase; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid | 2000 |
Interleukin-2: structural and biological relatedness to opioid peptides.
Topics: Analgesics; Animals; Antibodies; Antibodies, Monoclonal; beta-Endorphin; Brain Chemistry; Cross Reactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-2; Male; Mutagenesis, Site-Directed; Neuroimmunomodulation; Nociceptors; Opioid Peptides; Pain Threshold; Peptide Fragments; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Structure-Activity Relationship | 2000 |
Role of NOC/oFQ in impaired opioid-induced pial artery dilation following brain injury.
Topics: Animals; Brain Injuries; Cerebral Arteries; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Nociceptin; Opioid Peptides; Pia Mater; Swine; Vasodilation | 2000 |
Deciphering the origin of Met-enkephalin and Leu-enkephalin in Lobe-finned fish: cloning of australian lungfish proenkephalin.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Brain; Cloning, Molecular; DNA, Complementary; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fishes; Gene Dosage; Molecular Sequence Data; Polymerase Chain Reaction; Protein Precursors | 2000 |
Involvement of dynorphin in immobilization stress-induced antinociception in the mouse.
Topics: Animals; beta-Endorphin; Cerebral Ventricles; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Reaction Time; Restraint, Physical; Stress, Psychological | 2000 |
Modulation of humoral immune responses in the rat by centrally applied Met-Enk and opioid receptor antagonists: functional interactions of brain OP1, OP2 and OP3 receptors.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Hemolytic Plaque Technique; Immunoglobulins; Immunosuppressive Agents; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
The presence of antibacterial and opioid peptides in human plasma during coronary artery bypass surgery.
Topics: Amino Acid Sequence; Coronary Artery Bypass; Coronary Disease; Enkephalin, Methionine; Enkephalins; Escherichia coli; Escherichia coli Infections; Female; Gram-Positive Bacterial Infections; Humans; Immunoblotting; Male; Micrococcus luteus; Middle Aged; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Staphylococcal Infections; Staphylococcus aureus | 2000 |
Cardiac synthesis, processing, and coronary release of enkephalin-related peptides.
Topics: Animals; Coronary Vessels; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Male; Myocardium; Perfusion; Protein Precursors; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Time Factors | 2000 |
Basal levels and alcohol-induced changes in nociceptin/orphanin FQ, dynorphin, and enkephalin levels in C57BL/6J mice.
Topics: Alcohol Drinking; Alcohol-Induced Disorders, Nervous System; Animals; Brain; Brain Chemistry; Drug Administration Schedule; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nociceptin; Opioid Peptides; Pituitary Gland; Self Administration | 2000 |
In the african lungfish Met-enkephalin and leu-enkephalin are derived from separate genes: cloning of a proenkephalin cDNA.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; DNA, Complementary; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Fishes; Immunohistochemistry; Male; Molecular Sequence Data; Neurons; Protein Precursors | 2000 |
Decreases in endogenous opioid peptides in the rat medullo-coerulear pathway after chronic morphine treatment.
Topics: Animals; Blotting, Northern; Blotting, Western; Densitometry; Drug Implants; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Immunohistochemistry; In Situ Hybridization; Locus Coeruleus; Male; Medulla Oblongata; Microscopy, Electron; Morphine; Neural Pathways; Opioid Peptides; Presynaptic Terminals; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2000 |
Deletion of tyrosine hydroxylase gene reveals functional interdependence of adrenocortical and chromaffin cell system in vivo.
Topics: Adrenal Glands; Animals; Antigens, Differentiation; Catecholamines; Chromaffin Cells; Chromogranins; Corticosterone; Enkephalin, Methionine; Enkephalins; Female; Gene Deletion; Gene Expression; Humans; Immunohistochemistry; Male; Mice; Mice, Knockout; Neuropeptide Y; Phenylethanolamine N-Methyltransferase; Protein Precursors; RNA, Messenger; Tyrosine 3-Monooxygenase; Ubiquitin Thiolesterase | 2000 |
Involvement of opioid peptides in the regulation of reproduction in the prawn Penaeus indicus.
Topics: Animals; Cell Size; Enkephalin, Leucine; Enkephalin, Methionine; Female; Oocytes; Ovary; Penaeidae; Reproduction | 2000 |
Local opiate receptors in the sinoatrial node moderate vagal bradycardia.
Topics: Animals; Blood Pressure; Bradycardia; Coronary Vessels; Diprenorphine; Dogs; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Heart Rate; Narcotic Antagonists; Norepinephrine; Receptors, Opioid; Sinoatrial Node; Sympathomimetics; Vagus Nerve | 2001 |
Met-enkephalin is preferentially transported into the peripheral processes of primary afferent fibres in both control and HSV1-driven proenkephalin A overexpressing rats.
Topics: Afferent Pathways; Animals; Biological Transport; Enkephalin, Methionine; Enkephalins; Extracellular Space; Ganglia, Spinal; Genetic Vectors; Hindlimb; Ligation; Nerve Fibers; Protein Precursors; Rats; Reference Values; Sciatic Nerve; Simplexvirus; Spinal Cord | 2001 |
Withdrawal from alcohol in withdrawal seizure-prone and -resistant mice: evidence for enkephalin resistance.
Topics: Aluminum; Animals; Brain Chemistry; Central Nervous System Depressants; Digoxigenin; Enkephalin, Methionine; Enkephalins; Ethanol; Female; Half-Life; Mice; Mice, Inbred Strains; MSH Release-Inhibiting Hormone; Neuropeptides; Protein Precursors; Radioimmunoassay; RNA, Messenger; Seizures; Substance Withdrawal Syndrome | 2001 |
Antisera against endogenous opioids increase the nocifensive response to formalin: demonstration of inhibitory beta-endorphinergic control.
Topics: Animals; beta-Endorphin; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Formaldehyde; Immune Sera; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Nociceptors; Opioid Peptides; Pain | 2001 |
Colocalization of GABA, enkephalin and neuropeptide Y in the tectum of the green frog Rana esculenta.
Topics: Animals; Body Weight; Enkephalin, Methionine; Enkephalins; Female; gamma-Aminobutyric Acid; Male; Microscopy, Fluorescence; Neurons; Neuropeptide Y; Protein Binding; Ranidae | 2001 |
Effects of microiontophoretically-applied opioid peptides on Purkinje cells in the cat cerebellum.
Topics: Action Potentials; Animals; Cats; Cerebellum; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Iontophoresis; Male; Morphine; Opioid Peptides; Peptide Fragments; Purkinje Cells | 2000 |
Naloxone blocks transferred preconditioning in isolated rabbit hearts.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Hemodynamics; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardium; Naloxone; Rabbits; Radioimmunoassay; Random Allocation | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Endorphin and enkephalin ameliorate excessive synovial cell functions in patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; beta-Endorphin; Cell Division; Cell Nucleus; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Enkephalin, Leucine; Enkephalin, Methionine; Female; Gene Expression; Humans; Interleukin-1; Male; Matrix Metalloproteinase 9; Middle Aged; Neuroimmunomodulation; Opioid Peptides; Receptors, Opioid; Synovial Membrane; Synovitis; Tumor Necrosis Factor-alpha | 2001 |
Transient arterial occlusion raises enkephalin in the canine sinoatrial node and improves vagal bradycardia.
Topics: Animals; Blood Pressure; Bradycardia; Coronary Circulation; Coronary Vessels; Dogs; Enkephalin, Methionine; Enkephalins; Female; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Microdialysis; Norepinephrine; Sinoatrial Node; Vagus Nerve | 2001 |
Enkephalinergic control of the secretory activity of neurons producing stereoisomers of crustacean hyperglycemic hormone in the eyestalk of the crayfish Orconectes limosus.
Topics: Animals; Arthropod Proteins; Astacoidea; Axons; Brain; Dendrites; Enkephalin, Leucine; Enkephalin, Methionine; Eye; Fluorescent Antibody Technique; Invertebrate Hormones; Nerve Tissue Proteins; Neurons; Neurosecretory Systems; Stereoisomerism | 2002 |
Evidence for changes in brain enkephalin contents associated to male rat sexual activity.
Topics: Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Hypothalamus; Male; Mesencephalon; Radioimmunoassay; Rats; Sexual Behavior, Animal | 2002 |
[Selectivity of opioid peptide effects on excitability and various sensory inputs in LPl1 and PPl1 command neurons participating in defensive behavior of the snail Helix lucorum].
Topics: Action Potentials; Animals; Cell Membrane; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Escape Reaction; Extremities; Head; Helix, Snails; Neuronal Plasticity; Neurons; Opioid Peptides; Synapses | 2002 |
Delta opioid receptors inhibit vagal bradycardia in the sinoatrial node.
Topics: Animals; Bradycardia; Dogs; Enkephalin, Methionine; Enkephalins; Microdialysis; Peptide Fragments; Protein Precursors; Receptors, Opioid, delta; Sinoatrial Node; Sympathomimetics; Vagus Nerve | 2001 |
Effect of tianeptine and fluoxetine on the levels of Met-enkephalin and mRNA encoding proenkephalin in the rat.
Topics: Adrenal Glands; Animals; Antidepressive Agents, Second-Generation; Brain Chemistry; Enkephalin, Methionine; Enkephalins; Fluoxetine; In Situ Hybridization; Male; Pituitary Gland; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Thiazepines; Tissue Distribution | 2002 |
Met-enkephalin and preproenkephalin mRNA changes in the striatum of the nicotine abstinence mouse.
Topics: Animals; Behavior, Animal; Blotting, Northern; Corpus Striatum; Enkephalin, Methionine; Enkephalins; In Situ Hybridization; Male; Mice; Nicotine; Nucleus Accumbens; Protein Precursors; Radioimmunoassay; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors; Tissue Distribution | 2002 |
Correlated morphological and chemical phenotyping in myenteric type V neurons of porcine ileum.
Topics: Animals; Calcitonin Gene-Related Peptide; Choline O-Acetyltransferase; Enkephalin, Leucine; Enkephalin, Methionine; Female; Ileum; Immunohistochemistry; Male; Myenteric Plexus; Neurofilament Proteins; Neurons; Neuropeptides; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Presynaptic Terminals; Somatostatin; Swine | 2002 |
Integration of solid-phase extraction membranes for sample multiplexing: application to rapid protein identification from gel-isolated protein extracts.
Topics: Angiotensin I; Animals; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Male; Membranes, Artificial; Miniaturization; Prostate; Proteins; Rats | 2002 |
In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure.
Topics: Adult; Aminopeptidases; Antipsychotic Agents; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Female; Humans; Hydrolysis; In Vitro Techniques; Male; Middle Aged; Phenothiazines; Structure-Activity Relationship | 2003 |
Methionine-enkephalin and leucine-enkephalin increase interleukin-1 beta release in mixed glia cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Enkephalin, Leucine; Enkephalin, Methionine; Interleukin-1; Lipopolysaccharides; Naloxone; Narcotic Antagonists; Neuroglia; Rats; Rats, Wistar | 2002 |
Peptide separations and dissociation constants in nonaqueous capillary electrophoresis: comparison of methanol and aqueous buffers.
Topics: Buffers; Electrolytes; Electrophoresis, Capillary; Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Mathematics; Methanol; Models, Chemical; Neuropeptides; Peptides; Solvents; Stereoisomerism | 2003 |
A comparison between electrokinetic capillary chromatography and absorption spectroscopy for the analysis of peptide-micelle association by weak hydrophobic interactions.
Topics: Buffers; Cetrimonium; Cetrimonium Compounds; Chromatography, Micellar Electrokinetic Capillary; Dipeptides; Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Mathematics; Micelles; Peptides; Sodium Dodecyl Sulfate; Spectrophotometry; Surface-Active Agents | 2003 |
The regulation of steroidogenesis by opioid peptides in porcine theca cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; Cells, Cultured; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Estradiol; Female; Opioid Peptides; Progesterone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Steroids; Swine; Testosterone; Theca Cells | 2003 |
Developmental changes in the inhibition of cultured rat uterine cell proliferation by opioid peptides.
Topics: Aging; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Epidermal Growth Factor; Estradiol; Female; Inhibitory Concentration 50; Naloxone; Narcotic Antagonists; Opioid Peptides; Ovariectomy; Rats; Rats, Inbred Strains; Rats, Wistar; Uterus | 2003 |
A genetic algorithm with conformational memories for structure prediction of polypeptides.
Topics: Algorithms; Amino Acid Sequence; Computational Biology; Enkephalin, Leucine; Enkephalin, Methionine; Genetics; Models, Molecular; Molecular Structure; Peptides; Predictive Value of Tests; Protein Conformation; Protein Folding; Spectrum Analysis, Raman; Thermodynamics | 2003 |
Long-term effects of short and long periods of maternal separation on brain opioid peptide levels in male Wistar rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Corticosterone; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Maternal Deprivation; Opioid Peptides; Pituitary Gland; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Time Factors; Ultrasonics | 2003 |
The selective action of opioid peptides on excitability and the various sensory inputs of defensive behavior command neurons LPl1 and RPl1 of the common snail.
Topics: Action Potentials; Animals; Cell Membrane; Enkephalin, Leucine; Enkephalin, Methionine; Escape Reaction; Helix, Snails; Naloxone; Narcotic Antagonists; Neuronal Plasticity; Neurons; Opioid Peptides; Physical Stimulation; Quinine | 2003 |
The probability distribution of side-chain conformations in [Leu] and [Met]enkephalin determines the potency and selectivity to mu and delta opiate receptors.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, mu; Thermodynamics; Time Factors; X-Rays | 2003 |
Stress applied during primary immunization affects the secondary humoral immune response in the rat: involvement of opioid peptides.
Topics: Animals; Antibodies; Antibody Formation; Cattle; Electroshock; Enkephalin, Leucine; Enkephalin, Methionine; Immunity; Immunization; Immunization, Secondary; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Wistar; Serum Albumin, Bovine; Stress, Physiological; Stress, Psychological | 2003 |
Enkephalinergic involvement in substantia nigra in the modulation of hypothalamically-induced predatory attack behavior.
Topics: Aggression; Animals; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Enkephalin, Methionine; Enkephalins; Female; Hypothalamus; Male; Microinjections; Naloxone; Narcotic Antagonists; Predatory Behavior; Substantia Nigra | 2003 |
Gene expression of OGFr in the developing and adult rat brain and cerebellum.
Topics: Animals; Animals, Newborn; Binding Sites; Brain; Cell Differentiation; Cerebellum; Enkephalin, Methionine; Enkephalins; Female; Fetus; Gene Expression Regulation, Developmental; Ligands; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger | 2004 |
Cloning of prodynorphin cDNAs from the brain of Australian and African lungfish: implications for the evolution of the prodynorphin gene.
Topics: Africa; Amino Acid Sequence; Animals; Australia; Base Sequence; Biological Evolution; Brain; Cloning, Molecular; DNA, Complementary; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fishes; Molecular Sequence Data; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn.
Topics: Animals; Cattle; Cell Count; Drug Interactions; Enkephalin, Methionine; Enkephalins; Formaldehyde; Gene Expression Regulation; Hot Temperature; Immunohistochemistry; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pain; Pain Measurement; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2004 |
Differential mechanisms of antianalgesia induced by endomorphin-1 and endomorphin-2 in the ventral periaqueductal gray of the rat.
Topics: Analgesia; Animals; beta-Endorphin; Cholecystokinin; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Morphine; Naloxone; Oligopeptides; Periaqueductal Gray; Rats; Receptors, Opioid, mu; Substance P | 2005 |
Distribution of methionine and leucine enkephalin neurons within the social behavior circuitry of the male Syrian hamster brain.
Topics: Aggression; Animals; Brain; Brain Chemistry; Colchicine; Cricetinae; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; Male; Mesocricetus; Sexual Behavior, Animal; Social Behavior | 2004 |
Structural characterization of methionine and leucine enkephalins by hydrogen/deuterium exchange and electrospray ionization tandem mass spectrometry.
Topics: Deuterium; Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen; Spectrometry, Mass, Electrospray Ionization | 2005 |
Hypotensive effect of novel chimeric peptides of met-enkephalin and FMRFa.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; FMRFamide; Heart Rate; Hypotension; Male; Naloxone; Neuropeptides; Peptides; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Opioid; Vasodilator Agents | 2005 |
Capillary liquid chromatography with MS3 for the determination of enkephalins in microdialysis samples from the striatum of anesthetized and freely-moving rats.
Topics: Anesthesia; Animals; Brain Chemistry; Chromatography, Liquid; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Microdialysis; Monitoring, Physiologic; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2005 |
Analgesic activity of enkephalins following intracerebral administration in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Antagonism; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Tail | 1977 |
Substance P and opioid peptidergic innervation of the anterior eye segment of the rat: an immunohistochemical study.
Topics: Animals; Anterior Eye Segment; Ciliary Body; Conjunctiva; Cornea; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; Iris; Nociceptin; Oligopeptides; Opioid Peptides; Rats; Rats, Sprague-Dawley; Sclera; Substance P; Trabecular Meshwork | 2005 |
delta-opioid receptor-mediated actions on rostral ventromedial medulla neurons.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Calcium Channels; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; In Vitro Techniques; Lysine; Male; Medulla Oblongata; Membrane Potentials; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Serotonin; Substance P; Tryptophan Hydroxylase | 2005 |
Maternal deprivation increases vulnerability to morphine dependence and disturbs the enkephalinergic system in adulthood.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Brain; Choice Behavior; Conditioning, Psychological; Dialysis; Dose-Response Relationship, Drug; Drinking Behavior; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; In Situ Hybridization; Maternal Deprivation; Morphine; Morphine Dependence; Narcotics; Nucleus Accumbens; Pregnancy; Protein Precursors; Radioimmunoassay; Rats; Rats, Long-Evans; Receptors, Opioid, mu; RNA, Messenger; Self Administration; Sucrose; Time Factors; Tritium | 2005 |
A new electrochemical HPLC method for analysis of enkephalins and endomorphins.
Topics: Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Male; Microdialysis; Oligopeptides; Pain; Perfusion; Posterior Horn Cells; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 2006 |
Ischemic preconditioning increases the bioavailability of cardiac enkephalins.
Topics: Animals; Coronary Circulation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 2005 |
Lymphocytic ppENKmRNA, MEK-IR, and Dyn-IR in electroacupuncture.
Topics: Animals; Dynorphins; Electroacupuncture; Enkephalin, Methionine; Enkephalins; Immunity, Cellular; Immunohistochemistry; In Situ Hybridization; Lymphocytes; Mice; Mice, Inbred BALB C; RNA, Messenger | 2005 |
Capillary liquid chromatography and tandem mass spectrometry for the quantification of enkephalins in cerebrospinal fluid.
Topics: Capillary Action; Chromatography, High Pressure Liquid; Chromatography, Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Mass Spectrometry | 2005 |
Preproenkephalin targeted antisenses cross the blood-brain barrier to reduce brain methionine enkephalin levels and increase voluntary ethanol drinking.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Drinking Behavior; Enkephalin, Methionine; Enkephalins; Ethanol; Gene Targeting; Injections, Intravenous; Male; Protein Precursors; RNA, Antisense | 2006 |
Delta and mu opioid receptors from the brain of a urodele amphibian, the rough-skinned newt Taricha granulosa: cloning, heterologous expression, and pharmacological characterization.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Endorphin; Brain Chemistry; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Molecular Sequence Data; Naloxone; Phylogeny; Receptors, Opioid, delta; Receptors, Opioid, mu; Salamandridae; Sequence Alignment | 2006 |
The superior colliculus of the camel: a neuronal-specific nuclear protein (NeuN) and neuropeptide study.
Topics: Adaptation, Physiological; Animals; Biomarkers; Camelus; Cell Size; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; Male; Neurons; Nociceptors; Nuclear Proteins; Somatostatin; Staining and Labeling; Substance P; Superior Colliculi | 2006 |
Determination of enkephalin peptides by nonaqueous capillary electrophoresis with electrochemical detection.
Topics: Blood Chemical Analysis; Electrochemistry; Electrophoresis, Capillary; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Silicon Dioxide; Solvents | 2006 |
Variations in opioid peptide levels during the estrous cycle in Sprague-Dawley rats.
Topics: Animals; Brain; Enkephalin, Methionine; Enkephalins; Estrous Cycle; Female; Opioid Peptides; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 2006 |
A pulsed field gradient NMR diffusion investigation of enkephalin peptide-sodium dodecyl sulfate micelle association.
Topics: Amino Acids; Chromatography, Micellar Electrokinetic Capillary; Diffusion; Enkephalin, Leucine; Enkephalin, Methionine; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Micelles; Sodium Dodecyl Sulfate | 2006 |
Enkephalinergic afferents of the centromedial amygdala in the rat.
Topics: Afferent Pathways; Amygdala; Animals; Cholera Toxin; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Dyes; Immunohistochemistry; In Situ Hybridization; Male; Nerve Fibers; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger | 2006 |
Genetically engineered human mesenchymal stem cells produce met-enkephalin at augmented higher levels in vitro.
Topics: Analgesics; Analgesics, Opioid; Cell Proliferation; Cells, Cultured; DNA; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Gene Fusion; Genetic Engineering; Genetic Vectors; Green Fluorescent Proteins; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Pain; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2006 |
Amphetamine triggers an increase in met-enkephalin simultaneously in brain areas and immune cells.
Topics: Amphetamine; Animals; Blotting, Western; Brain; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Lymphocytes; Macrophages; Male; Protein Isoforms; Protein Precursors; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen; Thymus Gland | 2006 |
Vibrational dynamics of morphine in relation to Leu5--and Met5-enkephalins.
Topics: Analgesics, Opioid; Binding Sites; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Molecular Structure; Morphine; Receptors, Opioid; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman | 2006 |
Arginine vasopressin enhances periaqueductal gray synthesis and secretion of enkephalin and endorphin in the rat.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Neural Pathways; Organ Culture Techniques; Periaqueductal Gray; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; RNA, Messenger; Up-Regulation | 2006 |
Reactions of hydrogen atoms with met-enkephalin and related peptides.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Hydrogen; Peptides; Phosphatidylcholines | 2007 |
Opioid peptides as possible neuromodulators in the frog peripheral nerve system.
Topics: Action Potentials; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Rana ridibunda; Sciatic Nerve | 2007 |
Reactivity and oxidative potential of fructose and glucose in enkephalin-sugar model systems.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Fructose; Glucose; Maillard Reaction; Oxidation-Reduction | 2008 |
Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat.
Topics: Acetylcholine; Animals; Arginine Vasopressin; beta-Endorphin; Choline; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Norepinephrine; Opioid Peptides; Oxytocin; Pain; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Serotonin | 2007 |
Differences in neurogenesis differentiate between core and shell regions of auditory nuclei in the turtle (Pelodiscus sinensis): evolutionary implications.
Topics: Animals; Auditory Pathways; Auditory Perception; Autoradiography; Biological Evolution; Brain; Cell Differentiation; Diencephalon; Enkephalin, Methionine; Enkephalins; Female; Geniculate Bodies; Immunohistochemistry; Inferior Colliculi; Male; Mesencephalon; Neurons; Species Specificity; Substance P; Telencephalon; Thymidine; Turtles | 2007 |
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger | 2008 |
Capillary electrophoresis chemiluminescent detection system equipped with a two-step postcolumn flow interface for detection of some enkephalin-related peptides labeled with acridinium ester.
Topics: Acridines; Animals; Brain Chemistry; Buffers; Electrophoresis, Capillary; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Luminescent Measurements; Rats; Reproducibility of Results; Succinimides | 2008 |
Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Enkephalin, Methionine; Enkephalins; Entorhinal Cortex; Female; Humans; Male; Mice; Mice, Transgenic; Neural Pathways; Neurons; Protein Precursors; RNA, Messenger; Up-Regulation | 2008 |
An in vitro comparison of microdialysis relative recovery of Met- and Leu-enkephalin using cyclodextrins and antibodies as affinity agents.
Topics: Antibodies; Cyclodextrins; Enkephalin, Leucine; Enkephalin, Methionine; Microdialysis | 2008 |
Possible autocrine enkephalin regulation of catecholamine release in human pheochromocytoma cells.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Anti-Inflammatory Agents; Autocrine Communication; Catecholamines; Cell Separation; Cell Survival; Cells, Cultured; Child; Culture Media; Dexamethasone; Enkephalin, Methionine; Enkephalins; Female; Humans; Indicators and Reagents; Male; Middle Aged; Naloxone; Narcotic Antagonists; Pheochromocytoma | 2008 |
Distinct morphological and immunohistochemical features and different growth rates among four human neuroblastomas heterotransplanted into nude mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Child; Child, Preschool; Enkephalin, Leucine; Enkephalin, Methionine; Female; Galanin; Humans; Infant; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neuroblastoma; Neuropeptide Y; Secretory Vesicles; Serotonin; Transplantation, Heterologous; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 2008 |
Does the endogenous opiate system play a role in the Restless Legs Syndrome? A pilot post-mortem study.
Topics: Aged; Aged, 80 and over; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Immunohistochemistry; Male; Pilot Projects; Restless Legs Syndrome; Substantia Nigra; Thalamus; Tyrosine 3-Monooxygenase | 2009 |
Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzamides; beta-Endorphin; Blood Pressure; Cricetinae; Cyclic AMP; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypertension; Hypertrophy, Left Ventricular; Myocardial Contraction; Myocardium; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Systole; Ventricular Remodeling | 2009 |
Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off-line to capillary LC with multistage MS.
Topics: Animals; beta-Endorphin; Chromatography, High Pressure Liquid; Corpus Striatum; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Limit of Detection; Male; Microdialysis; Neuropeptides; Oligopeptides; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2009 |
Intrathecal transplantation of autologous macrophages genetically modified to secrete proenkephalin ameliorated hyperalgesia and allodynia following peripheral nerve injury in rats.
Topics: Animals; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Macrophages; Male; Pain; Pain Management; Pain Measurement; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Neuropathy; Spinal Cord; Time Factors; Transfection; Transplantation, Autologous | 2009 |
Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system.
Topics: Analgesics; Animals; Arginine Vasopressin; Choline; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamic Acid; Indoles; Male; Opioid Peptides; Oxytocin; Pain; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin | 2009 |
Analogues of both Leu- and Met-enkephalin containing a constrained dipeptide isostere prepared from a Baylis-Hillman adduct.
Topics: Amino Acid Sequence; Animals; Dipeptides; Drug Design; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Glycylglycine; Guinea Pigs; Ileum; Male; Mice; Models, Molecular; Molecular Conformation; Molecular Mimicry; Molecular Structure; Myenteric Plexus; Neurotransmitter Agents; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Vas Deferens | 2010 |
Dilution-free analysis from picoliter droplets by nano-electrospray ionization mass spectrometry.
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Microfluidics; Oils; Spectrometry, Mass, Electrospray Ionization | 2009 |
Freezing of enkephalinergic functions by multiple noxious foci: a source of pain sensitization?
Topics: Animals; Enkephalin, Methionine; Enkephalins; Extremities; Male; Neural Inhibition; Pain; Protein Precursors; Rabbits; Rats; Rats, Sprague-Dawley; Spinal Cord; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal | 2009 |
[Methionine-enkephalin (Met5-Enk) and leucine-enkephalin (Leu5-Enk)].
Topics: Enkephalin, Leucine; Enkephalin, Methionine; Humans; Radioimmunoassay | 2010 |
Regulated proenkephalin expression in human skin and cultured skin cells.
Topics: Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fibroblasts; Humans; Keratinocytes; Lipopeptides; Lipopolysaccharides; Melanocytes; Melanoma; Protein Precursors; Skin; Skin Neoplasms; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2011 |
Phylogenetic diversity and functional efficacy of the C-terminally expressed heptapeptide unit in the opioid precursor polypeptide proenkephalin A.
Topics: Animals; Enkephalin, Methionine; Enkephalins; Guinea Pigs; HEK293 Cells; Humans; Oligopeptides; Peptide Fragments; Phylogeny; Polymorphism, Genetic; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid; Sequence Analysis; Sulfur Radioisotopes; Vertebrates | 2011 |
HPLC/MS/MS for quantification of two types of neurotransmitters in rat brain and application: myocardial ischemia and protection of Sheng-Mai-San.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Enkephalin, Leucine; Enkephalin, Methionine; Limit of Detection; Male; Myocardial Ischemia; Neuroprotective Agents; Neurotransmitter Agents; Norepinephrine; Random Allocation; Rats; Rats, Wistar; Reproducibility of Results; Serotonin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Technology, Pharmaceutical | 2011 |
Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides.
Topics: Animals; beta-Endorphin; Catheterization; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Microinjections; Naloxone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Periaqueductal Gray; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 2011 |
Microdialysis and mass spectrometric monitoring of dopamine and enkephalins in the globus pallidus reveal reciprocal interactions that regulate movement.
Topics: Amino Acids; Amphetamine; Animals; Benzazepines; Central Nervous System Stimulants; Dopamine; Dopamine Antagonists; Drug Interactions; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Globus Pallidus; Male; Mass Spectrometry; Microdialysis; Motor Activity; Naloxone; Narcotic Antagonists; Raclopride; Rats; Rats, Sprague-Dawley | 2011 |
The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.
Topics: Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System | 2011 |
Conformational space exploration of Met- and Leu-enkephalin using the MOLS method, molecular dynamics, and Monte Carlo simulation--a comparative study.
Topics: Computational Biology; Enkephalin, Leucine; Enkephalin, Methionine; Molecular Dynamics Simulation; Monte Carlo Method; Protein Conformation | 2012 |
New insights into the neuroanatomical distribution and phylogeny of opioids and POMC-derived peptides in fish.
Topics: Analgesics, Opioid; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Fishes; Peptides; Pro-Opiomelanocortin | 2012 |
Disturbances in behavior and cortical enkephalin gene expression during the anticipation of ethanol in rats characterized as high drinkers.
Topics: Alcohol Drinking; Animals; Anticipation, Psychological; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Ethanol; Exploratory Behavior; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2012 |
Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide.
Topics: Adolescent; Adult; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Humans; Male; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; Sperm Motility | 2012 |
Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the δ-Opioid Receptor.
Topics: Animals; Binding, Competitive; Cell Line; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Indicators and Reagents; Mice; Mitogen-Activated Protein Kinases; Models, Molecular; Molecular Conformation; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 2010 |
Delivery of neuropeptides from the periphery to the brain: studies with enkephalin.
Topics: Analgesics; Animals; Blood-Brain Barrier; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Injections, Intraperitoneal; Lipids; Male; Mice; Mice, Inbred ICR; Neuropeptides | 2010 |
Repetitive electroacupuncture causes prolonged increased met-enkephalin expression in the rVLM of conscious rats.
Topics: Acupuncture Points; Animals; Arcuate Nucleus of Hypothalamus; Arterial Pressure; Consciousness; Electroacupuncture; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Heart Rate; Medulla Oblongata; Protein Precursors; Rats; Rats, Sprague-Dawley; Telemetry; Time Factors | 2012 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |
Exposure to exogenous enkephalins disrupts reproductive development in the Eastern lubber grasshopper, Romalea microptera (Insecta: Orthoptera).
Topics: Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Grasshoppers; Male; Naloxone; Oocytes; Ovary; Reproduction; Testis | 2012 |
Rapid preconcentration for liquid chromatography-mass spectrometry assay of trace level neuropeptides.
Topics: Animals; Brain Chemistry; Chromatography, Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Globus Pallidus; Limit of Detection; Male; Microdialysis; Neuropeptides; Potassium; Rats; Spectrometry, Mass, Electrospray Ionization | 2013 |
A single neonatal injury induces life-long deficits in response to stress.
Topics: Amygdala; Analgesia; Anhedonia; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Densitometry; Enkephalin, Methionine; Enkephalins; Female; Food Preferences; Immunohistochemistry; In Situ Hybridization; Opioid Peptides; Periaqueductal Gray; Pregnancy; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Septum of Brain; Stress, Psychological; Sucrose; Swimming | 2013 |
Photopolymerization of acrylamide as a new functionalization way of silica monoliths for hydrophilic interaction chromatography and coated silica capillaries for capillary electrophoresis.
Topics: Acrylamide; Acrylic Resins; Chromatography, Liquid; Electrophoresis, Capillary; Enkephalin, Leucine; Enkephalin, Methionine; Hydrophobic and Hydrophilic Interactions; Nucleosides; Polymerization; Silicon Dioxide; Ultraviolet Rays | 2014 |
Fine refinement of solid-state molecular structures of Leu- and Met-enkephalins by NMR crystallography.
Topics: Crystallography; Enkephalin, Leucine; Enkephalin, Methionine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure | 2014 |
Hypothalamic peptides controlling alcohol intake: differential effects on microstructure of drinking bouts.
Topics: Alcohol Drinking; Animals; Enkephalin, Methionine; Enkephalins; Galanin; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Neuropeptides; Orexins; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley | 2014 |
Constant light suppresses production of Met-enkephalin-containing peptides in cultured splenic macrophages and impairs primary immune response in rats.
Topics: Animals; Circadian Rhythm; Cytokines; Down-Regulation; Enkephalin, Methionine; Enkephalins; Immunoglobulin M; Immunohistochemistry; Interleukin-2; Light; Macrophages; Male; Melatonin; Naloxone; Phenotype; Photoperiod; Protein Precursors; Rats; Rats, Wistar; Spleen | 2015 |
The effects of exercise training programs on plasma concentrations of proenkephalin Peptide F and catecholamines.
Topics: Adrenal Medulla; Adult; Catecholamines; Enkephalin, Methionine; Enkephalins; Exercise; Humans; Male; Protein Precursors; Young Adult | 2015 |
Enteric neuromodulators and mucus discharge in a fish infected with the intestinal helminth Pomphorhynchus laevis.
Topics: Acanthocephala; Animals; Cyprinidae; Enkephalin, Leucine; Enkephalin, Methionine; Fish Diseases; Helminthiasis, Animal; Intestinal Mucosa; Neurotransmitter Agents; Serotonin | 2015 |
Preparation of a pipette tip-based molecularly imprinted solid-phase microextraction monolith by epitope approach and its application for determination of enkephalins in human cerebrospinal fluid.
Topics: Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epitopes; Equipment Design; Humans; Limit of Detection; Microscopy, Electron, Scanning; Molecular Imprinting; Neoplasms; Pain; Polymers; Reproducibility of Results; Solid Phase Microextraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Surface Properties | 2015 |
Endometriosis Is Associated With a Shift in MU Opioid and NMDA Receptor Expression in the Brain Periaqueductal Gray.
Topics: Animals; beta-Endorphin; Endometriosis; Enkephalin, Leucine; Enkephalin, Methionine; Female; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2016 |
Mapping of methionine-enkephalin-arg
Topics: Aged, 80 and over; Diencephalon; Enkephalin, Methionine; Enkephalins; Female; Humans; Immunohistochemistry; Male; Protein Precursors | 2016 |
Acute Hypoxia Induces Enkephalin Production and Release in an Adrenergic Cell Line Model of Neonatal Chromaffin Cell Responses to Hypoxic Stress.
Topics: Adrenal Medulla; Animals; Blood Pressure; Cell Line; Chromaffin Cells; Enkephalin, Methionine; Enkephalins; Hypoxia; Mice; Norepinephrine | 2018 |
Alanine scan of sialorphin and its hybrids with opiorphin: synthesis, molecular modelling and effect on enkephalins degradation.
Topics: Acetylation; Alanine; Amino Acid Sequence; Enkephalin, Methionine; Enkephalins; Models, Molecular; Neprilysin; Oligopeptides; Peptides; Protein Binding; Protein Conformation; Proteolysis; Salivary Proteins and Peptides; Solid-Phase Synthesis Techniques | 2018 |
Determination of methionine-enkephalin and leucine-enkephalin by LC-MS in human plasma: Study of pre-analytical stability.
Topics: Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Mass Spectrometry; Molecular Structure | 2018 |
Enkephalin degradation in serum of patients with inflammatory bowel diseases.
Topics: Adult; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Crohn Disease; Enkephalin, Leucine; Enkephalin, Methionine; Female; Half-Life; Humans; Male; Prospective Studies; Proteolysis; Sex Factors; Spectrometry, Mass, Electrospray Ionization | 2019 |
Synthesis and biological evaluation of quercetin and resveratrol peptidyl derivatives as potential anticancer and antioxidant agents.
Topics: Antineoplastic Agents; Antioxidants; Cell Proliferation; Chromatography, High Pressure Liquid; Dietary Supplements; Enkephalin, Leucine; Enkephalin, Methionine; Esters; HCT116 Cells; Humans; MCF-7 Cells; Neoplasms; Peptides; Phytochemicals; Quercetin; Resveratrol; Solubility; Transforming Growth Factor beta | 2019 |
Proenkephalin
Topics: Amphiregulin; Animals; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Female; Homeostasis; Humans; Immune Tolerance; Interleukin-2 Receptor alpha Subunit; Male; Mice; Mice, Inbred C57BL; Protein Precursors; Self Tolerance; Skin; T-Lymphocytes, Regulatory; Ultraviolet Rays; Wound Healing | 2020 |
Contribution of the μ opioid receptor and enkephalin to the antinociceptive actions of endomorphin-1 analogs with unnatural amino acid modifications in the spinal cord.
Topics: Analgesics; Animals; Chronic Pain; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Mice; Naloxone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu; Spinal Cord | 2021 |
HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling.
Topics: Analgesics, Opioid; Animals; Antibodies, Neutralizing; Antineoplastic Agents; Cisplatin; Enkephalin, Methionine; Enkephalins; Female; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Hyperalgesia; Ligands; Male; Mice; Mice, Inbred C57BL; Narcotic Antagonists; Neuralgia; Niacinamide; Receptors, Opioid, delta | 2022 |
Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Mice; Narcotic Antagonists; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; RNA, Messenger | 2022 |
Na
Topics: Analgesics; Animals; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Hyperalgesia; Mice; NAV1.7 Voltage-Gated Sodium Channel; Pain; Rats | 2023 |
Synthesis, in vitro opiate activity, and intramolecular tyrosine--tryptophan distances of [4-tryptophan]enkephalin analogues. A reassessment of conformational models of enkephalin in solution.
Topics: Animals; Chemical Phenomena; Chemistry; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Solutions; Spectrometry, Fluorescence; Structure-Activity Relationship; Thermodynamics; Tryptophan; Tyrosine | 1980 |
Design, synthesis, and binding characteristics of an opiate receptor mimetic peptide.
Topics: Binding, Competitive; Chromatography, Gel; Circular Dichroism; Dialysis; Enkephalin, Leucine; Models, Molecular; Protein Conformation; Receptors, Opioid; Spectrophotometry, Ultraviolet; Thermodynamics | 1984 |
Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations.
Topics: Animals; Enkephalins; Guanidine; Humans; Magnetic Resonance Spectroscopy; Peptides, Cyclic; Rats; Receptors, Opioid, mu; Structure-Activity Relationship; Thiourea | 2013 |
Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides.
Topics: Animals; Carbohydrates; Enkephalins; Glycopeptides; Glycosylation; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Protein Conformation; Receptors, Opioid; Structure-Activity Relationship | 2017 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |