enkephalin, leucine has been researched along with enkephalin, leucine-2-alanine in 933 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 684 (73.31) | 18.7374 |
| 1990's | 227 (24.33) | 18.2507 |
| 2000's | 18 (1.93) | 29.6817 |
| 2010's | 3 (0.32) | 24.3611 |
| 2020's | 1 (0.11) | 2.80 |
| Authors | Studies |
|---|---|
| Almquist, RG; Olsen, CM; Toll, L; Uyeno, ET | 1 |
| Nezu, J; Nozawa, T; Sai, Y; Tamai, I; Tsuji, A | 1 |
| Bianucci, AM; Macchia, M; Massarelli, I; Minutolo, F; Prota, G | 1 |
| Afanas'ev, SA; Kravchenko, AI; Lishmanov, IuB; Rebrova, TIu | 1 |
| Khugaeva, VK | 3 |
| Bowen, WD; Farmer, SC; Mattia, A; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 2 |
| Kowalski, J; Petrillo, P; Sbacchi, M; Tavani, A | 1 |
| Barnard, EA; Richardson, A; Simon, J | 1 |
| Colombo, M; La Regina, A; Petrillo, P; Tavani, A | 1 |
| Law, PY; Loh, HH; Roerig, SC | 1 |
| Carpenter, DO; Kemenes, G; Rózsa, KS; Stefano, G | 1 |
| Kane, K; McIntosh, M; Parratt, J | 1 |
| Eriksson, PS; Hansson, E; Rönnbäck, L | 2 |
| Garzón, J; Sánchez-Blázquez, P | 5 |
| Ko, JL; Lee, NM; Loh, HH | 1 |
| Dondi, D; Limonta, P; Maggi, R; Martini, L; Piva, F | 1 |
| Childers, SR; Fleming, L; Konkoy, C; Marckel, D; Pacheco, M; Sexton, T; Ward, S | 1 |
| Olianas, MC; Onali, P | 1 |
| Kondo, M; Matsumoto, H; Ohno, M; Sakamoto, H; Shimohigashi, Y; Takada, K; Yasunaga, T | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 1 |
| Bowen, WD; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Elde, R; Lane, CM; Lee, NM; Loh, HH | 1 |
| Finberg, RW; Heagy, W; Shipp, MA | 1 |
| Jin, W; Lee, NM; Loh, HH; Thayer, SA | 2 |
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| De Montis, MG; Fadda, P; Fratta, W; Gessa, GL; Martellotta, MC | 1 |
| Archer, S; Bidlack, JM; Jiang, Q; Seyed-Mozaffari, A | 1 |
| Barbarash, NA; Khaliulin, IG; Lishmanov, IuB; Maslov, LN | 1 |
| Kalenchuk, VU; Kozlova, MV | 1 |
| Napier, TC | 1 |
| Ausiello, CM; Bongiorno, L; Marini, M; Roda, LG; Urbani, A | 1 |
| Abe, I; Fujishima, M; Kobayashi, K; Matsumura, K; Tominaga, M; Tsuchihashi, T | 1 |
| Bowen, WD; Jiang, Q; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Lazarus, LH; Salvadori, S; Tomatis, R; Wilson, WE | 1 |
| Millan, MJ; Morris, BJ | 1 |
| Abdelhamid, EE; Takemori, AE | 1 |
| Chang, SC; Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Gressler, Iu; Slepushkin, VD | 1 |
| Haddad, GG; Xia, Y | 1 |
| Bennett, LE; Fleming, WW; Leedham, JA; Taylor, DA | 1 |
| Cone, RI; Lameh, J; Sadée, W | 1 |
| Ambo, A; Sasaki, Y; Suzuki, K | 1 |
| Ford, MJ; Meriney, SD; Oliva, D; Pilar, G | 1 |
| Fadda, P; Fratta, W; Tortorella, A | 1 |
| Lishmanov, IuB; Maslov, LN | 1 |
| Barfolomeev, SD; Kurochkin, IN; Melikhova, EV; Sukhovlin, TK | 1 |
| Chang, LR; Loh, HH; Tao, PL; Tsai, CL | 1 |
| Imanishi, Y; Kimura, S; Sasaki-Yagi, Y | 1 |
| Izykenova, GA; Taranova, NP | 1 |
| Jacobson, AE; Ni, Q; Rice, KC; Rothman, RB; Xu, H | 1 |
| Kapoor, R; Willoughby, JO | 1 |
| Alberch, J; Arenas, E; Marsal, J | 1 |
| Kuhar, MJ; Wamsley, JK; Zarbin, MA | 1 |
| Bugajski, J; Fogel, WA; Turon, M | 1 |
| Shimada, Y; Yamada, K; Yoshida, S | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A | 1 |
| Khokhlov, AP; Yarygin, KN | 1 |
| Burks, TF; Davis, P; Haaseth, RC; Hruby, VJ; Kramer, TH; Matsunaga, TO; Toth, G | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 2 |
| Bagetta, G; De Sarro, GB; Nisticò, G; Rispoli, V; Sakurada, S | 1 |
| Allen, JT; Brostrom, PA; DeHaven-Hudkins, DL; Ferkany, JW; Kaplita, PV; Lesko, LJ; Mavunkel, BJ; Rzeszotarski, WJ; Steranka, LR | 1 |
| Lee, AY; Tai, KK; Wong, TM | 1 |
| Benyhe, S; Borsodi, A; Varga, E; Wollemann, M | 1 |
| Crain, SM; Shen, KF | 3 |
| Green, IC; Khawaja, XZ; Thorpe, JR; Titheradge, MA | 1 |
| Collins, JG; Kitahata, LM; Nakagawa, I; Nakatani, K; Omote, K | 1 |
| Amerini, S; Ledda, F; Mantelli, L; Rubino, A | 1 |
| Giuliani, S; Maggi, CA; Meli, A | 2 |
| Chalmers, J; Drolet, G; Morilak, DA | 1 |
| Suh, HH; Tseng, LF | 1 |
| Amerini, S; Ledda, F; Mantelli, L | 2 |
| Belcheva, S; Kosteljanetz, N; Kupenova, P; Popova, E; Vitanova, L | 1 |
| Han, JS; Mei, L | 1 |
| Fromm, M; Reutter, W; Riecken, EO; Schulzke, JD | 1 |
| Ayesta, FJ; Flórez, J | 1 |
| Barnard, EA; Demoliou-Mason, CD; Hanley, MR; Wong, YH | 1 |
| Pencheva, N; Radomirov, R; Venkova, K | 1 |
| Katki, AG; Schwarz, S | 1 |
| Costa, T; Gless, C; Herz, A; Lang, J | 1 |
| Biswas, R; Maneckjee, R; Vonderhaar, BK | 1 |
| Higashijima, T; Milon, A; Miyazawa, T | 1 |
| Bowen, WD; Calcagnetti, DJ; Holtzman, SG | 1 |
| McKenzie, FR; Milligan, G | 1 |
| Donich, SG; Grebenchikov, OA; Karelin, AA; Korotkina, RN; Shloznikov, BM; Sitnikov, AV | 1 |
| Fujioka, T; Higashijima, T; Inoue, F; Kuriyama, M; Miura, Y | 1 |
| Jiang, Q; Porreca, F; Sheldon, RJ | 1 |
| Burks, TF; Davis, P; Hruby, VJ; Knapp, RJ; Shimohigashi, Y; Toth, G; Vaughn, LK; Wire, WS; Yamamura, HI | 1 |
| Attali, B; Saya, D; Vogel, Z | 1 |
| Likhvantsev, VM; Shloznikov, BM; Titov, MI; Vinogradov, AV | 1 |
| Cai, LQ; Szeto, HH; Zhu, YS | 1 |
| Donich, SG; Fomchenkov, EP; Grebenchikova, OA; Kuznetsov, AIu; Likhvantsev, VV; Makhmutov, RF; Peretrukin, AI; Shloznikov, BM | 1 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 2 |
| Lasukova, TV | 1 |
| Butsugan, Y; Fukuta, N; Ito, N; Kagami, T; Kawai, M; Kudo, Y; Maruyama, M | 1 |
| Mulder, AH; Schoffelmeer, AN; Van Vliet, BJ | 1 |
| Chalmers, J; Drolet, G; Morilak, D | 1 |
| Fuentes, JA; Iglesias, T; Jiménez, I | 1 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Liebmann, C; Neubert, K; Repke, H; Schnittler, M; Schrader, U; Schulze, HP | 1 |
| Bowen, WD; Mosberg, HI; Porreca, F; Qi, JA; Rothman, RB | 1 |
| Duan, SM; Fukuda, A; Hori, T; Oomura, Y; Shimizu, N | 1 |
| Lutfy, K; Sierra, V; Yoburn, BC | 2 |
| Didenko, VA; Dudko, VA; Fedorova, NA; Zoloev, GK | 1 |
| Bulgakov, SA; Fedenko, VV; Fomin, VB; Georgadze, AK | 1 |
| Golikov, AP; Riabinin, VA | 1 |
| Dygai, AM; Goldberg, ED; Shakhov, VP; Zakharova, O | 1 |
| Berezhnova, NI; Shvets, SI; Timoshin, SS | 1 |
| Afonskaia, NI; Anikin, AIu; Kargina-Terent'eva, RA | 1 |
| Bikmulina, FS; Fomchenko, EP; Petrov, OV; Shloznikov, BM; Smol'nikov, PV; Vinogradov, VL | 1 |
| Andreev, AI; Grebenchikov, OA; Karelin, AA; Kuzin, MI; Likhvantsev, BV; Shloznikov, BM; Sitnikov, AV; Tverskoĭ, AL | 1 |
| Anisimov, VN; Bortkevich, SM | 1 |
| Gonzalez, JP; Patel, A; Sewell, RD; Smith, HJ; Williams, PS; Yu, Z | 1 |
| Kenny, AJ; Matsas, R; Rattray, M; Turner, AJ | 1 |
| Cherubini, E; Morita, K; North, RA | 1 |
| Dua, AK; LaBella, FS; Pinsky, C | 1 |
| Goodman, RR; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Hahn, EF; Itzhak, Y; Johnson, N; Nishimura, S; Pasternak, GW | 1 |
| Hansen, HA; Mulder, AH; Schoffelmeer, AN; Stoof, JC | 2 |
| Dawson, G; Scheideler, MA | 1 |
| Mulder, AH; Schoffelmeer, AN; Wierenga, EA | 1 |
| Aanonsen, LM; Wilcox, GL | 1 |
| Botta, M; Ceccarelli, S; De Angelis, F; Nicoletti, R | 1 |
| Bulgakov, SA; Shcherbakova, NV; Smagin, VG; Vinogradov, VA; Zverkov, IV | 1 |
| Galetta, S; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Istranov, LP; Khulup, GIa; Medvedev, OS; Spevak, SE; Titov, MI | 1 |
| Cupo, A; Kaldy, P | 1 |
| Berry-Kravis, E; Dawson, G; Derechin, V; Kazmierczak, BI | 1 |
| Bodnar, RJ; Burks, TF; Clark, JE; Hahn, EF; Pasternak, GW; Williams, CL | 1 |
| Hescheler, J; Rosenthal, W; Schultz, G; Tang, M; Trautwein, W; Wulfern, M; Yajima, M | 1 |
| Chalazonitis, A; Crain, SM; Shen, KF | 1 |
| Yaksh, TL | 1 |
| Borson, DB; Djokic, TD; Nadel, JA; Sekizawa, K | 1 |
| Filippovich, IuB; Fomina, GG; Lapteva, TI; Mikodona, EV | 1 |
| Bottà, G; Cremaschi, D; Meyer, G; Rossetti, C | 1 |
| Beitner, DB; Duman, RS; Nestler, EJ | 1 |
| Cote, A; Haddad, GG; Rosen, CL | 1 |
| Fedotova, TV; Lishmanov, IuB; Titov, MI | 1 |
| Costa, T; Lang, J | 1 |
| Iyengar, S; Kim, HS; Marien, MR; McHugh, D; Wood, PL | 1 |
| Stevens, CW; Yaksh, TL | 2 |
| Zoloev, GK | 4 |
| Costa, T; Herz, A; Ott, S | 1 |
| Costa, T; Ott, S | 2 |
| Charcosset, JY; Garbay-Jaureguiberry, C; Jacquemin-Sablon, A; Rigaudy, P; Roques, BP | 1 |
| deGroat, WC; Hisamitsu, T; Nagel, J; Roppolo, JR; Thor, KB; Tuttle, P | 1 |
| Beamer, KC; Vargish, T | 1 |
| Kawakita, Y; Onishi, H; Soma, T; Yamagami, S | 1 |
| Kwen-Jen, C; Russell, RD | 1 |
| McLaughlin, PJ; Zagon, IS | 2 |
| Kobylyansky, AG; Nesterenko, PN; Pivovarov, AS; Yarygin, KN | 1 |
| Kobylyansky, AG | 1 |
| Bykov, V; George, C; Jacobson, AE; Kim, CH; Klee, WA; Long, JB; Mattson, MV; Rice, KC; Rothman, RB; Streaty, RA | 1 |
| Bogdanov, AN; Iarygin, KN; Pavlov, SA; Shugurov, VA; Vinogradov, VA | 1 |
| Beaumont, A; Brouet, JC; Roques, BP | 1 |
| Brown, DA; Docherty, RJ; McFadzean, I | 1 |
| Grässler, J; Scheuch, DV; Slepushkin, VD; Zoloev, GK | 1 |
| Kosterlitz, HW; La Regina, A; Petrillo, P; Robson, LE; Sbacchi, M; Tavani, A | 1 |
| Kaiser, ET; Taylor, JW | 1 |
| Costa, T; Herz, A | 1 |
| Aleksandrovich, AG; Timoshin, SS; Uchakina, RV; Zhdanova, TF | 1 |
| Brantl, V; Liebmann, C; Schrader, U | 1 |
| Grehn, L; Herrera-Marschitz, M; Terenius, L; Ungerstedt, U | 1 |
| Costa, T; Klinz, FJ | 1 |
| Bogdanov, EG | 1 |
| Bhargava, HN; Ramarao, P | 1 |
| de Castiglione, R; Guglietta, A; Lazarus, LH; Wilson, WE | 1 |
| Garzon, J; Landahl, HD; Lee, NM | 1 |
| Algeri, S; Botta, G; Cremaschi, D; Meyer, G; Tavani, A | 1 |
| Kumazawa, T; Minagawa, M; Mizumura, K; Sato, J | 1 |
| Rooney, KF; Sewell, RD | 1 |
| Gordeev, VF; Grigorevskiĭ, VP; Pashutin, SB; Priĭmak, SA; Satrapinskiĭ, VIu; Shatalov, VN; Vinogradov, VA | 1 |
| Bocharova, VS; Botsmanov, KV; Grigorevskiĭ, VP; Tsvirkun, VV | 1 |
| Bowen, WD; Herkenham, M; Jacobson, AE; Pert, CB; Rice, KC; Rothman, RB | 1 |
| Adrian, K; Buntrock, P; Diezel, W; Kohl, A; Titov, MI; Werner, A | 1 |
| Dvortsin, GF | 1 |
| Grigorevskiĭ, VP; Karelin, AA; Korotkina, RN | 1 |
| Argintaev, ES; Prum, IA; Slepushkin, VD; Sokolovich, GE; Zoloev, GK | 1 |
| Pashutin, SB | 1 |
| Grigorevskiĭ, VP; Karelin, AA; Korotkina, RN; Pomelov, VS; Shloznikov, BM | 1 |
| Fujioka, T; Inoue, F; Kuriyama, M | 2 |
| Garzón, J; Sánchez-Blázquez, P; Ulibarri, I | 1 |
| Buiavykh, AG; Ezhov, VA | 1 |
| Dhingra, MM; Saran, A | 1 |
| Poiarkov, VD; Savitskiĭ, GG; Slepushkin, VD; Sokolovich, GE; Zoloev, GK | 1 |
| Dygaĭ, AM; Gol'dberg, ED; Shakhov, VP; Zakharova, OIu | 1 |
| Costa, T; Herz, A; Vachon, L | 4 |
| Costa, T; Herz, A; Kimura, H; Pfeiffer, A; Shimohigashi, Y; Stammer, CH | 1 |
| Bowen, WD; Hellewell, SB; Huey, R; Kelemen, M; Stewart, D | 1 |
| Rauch, RJ; Stephenson, JD; Stolerman, IP | 1 |
| Petkov, VD; Radomirov, R; Venkova, K | 2 |
| Herblin, WF; Kauer, JC; Tam, SW | 1 |
| Pasternak, GW; Recht, LD | 1 |
| Kamikubo, K; Miura, K; Murase, H; Murayama, M; Tsurumi, K; Yasuda, K | 2 |
| Cross, AJ; Hille, C; Slater, P | 1 |
| Hoffman, PL; Khatami, S; Salafsky, B; Shibuya, T | 1 |
| Moak, CM; Murphy, MG; Rao, BG | 1 |
| Hill, JM; Ostrowski, NL; Pert, A; Pert, CB | 1 |
| Burnstock, G; Hoyle, CH; James, S; Jass, JR; Jeffrey, IJ; Lennard-Jones, JE | 1 |
| Garbay-Jaureguiberry, C; Jacquemin-Sablon, A; Le Pecq, JB; Rigaudy, P; Roques, BP | 1 |
| Chuang, DM; Zhu, XZ | 1 |
| Kamikubo, K; Matsuda, M; Miura, K; Murase, H; Murayama, M | 1 |
| De Souza, EB; Kuhar, MJ; Schmidt, WK | 1 |
| Bowen, WD; Jacobson, AE; Rice, KC; Rodrigues, PA; Wanzor, TE | 1 |
| Castiglione-Morelli, MA; Pastore, A; Tancredi, T; Temussi, PA | 1 |
| Bidlack, JM; O'Malley, WE; Schulz, R | 1 |
| Coscia, CJ; Petta, DE; Spain, JW | 2 |
| Coscia, CJ; Oetting, GM; Szücs, M | 2 |
| Kamikubo, K; Miura, K; Murase, H; Niwa, M; Nozaki, M; Tsurumi, K | 2 |
| Imai, T; Kamikubo, K; Miura, K; Miura, Y; Miyashita, T; Murase, H; Nakamura, S; Niwa, M; Satoh, T; Tomita, A | 1 |
| Lovett, JA; Portoghese, PS | 3 |
| Bowen, WD; Huey, R; Kelemen, M; Stewart, D | 1 |
| Driscoll, P; Frischknecht, HR; Lazega, D; Siegfreid, B; Waser, PG | 1 |
| Costa, T; Herz, A; Lang, J; Przewłocki, R | 1 |
| Aoyagi, H; Costa, T; Izumiya, N; Kato, T; Lee, S; Mihara, H; Shimohigashi, Y | 2 |
| Smith, CB | 1 |
| Arefolov, VA; Khaĭsman, EB; Malikova, LA | 1 |
| Clark, CR; Halfpenny, PR; Hill, RG; Horwell, DC; Hughes, J; Jarvis, TC; Rees, DC; Schofield, D | 1 |
| Larson, DL; Lipkowski, AW; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Kelly, EC; McKenzie, FR; Milligan, G; Spiegel, AM; Unson, CG | 1 |
| Gramsch, C; Herz, A; Kosin, S; Schulz, R | 1 |
| Belousov, AS; Kurochkin, IN; Skliankina, OA; Varfolomeev, SD; Zaĭtsev, SV | 1 |
| Henke, PG; Ray, A; Sullivan, RM | 1 |
| Bolger, GT; Marcus, KA; Skolnick, P; Thibou, R; Weissman, BA | 1 |
| Bykov, V; Ofri, D; Rice, KC; Rothman, RB | 1 |
| Ishizuka, Y; Oka, T | 1 |
| Keldysh, PL; Kurochkin, IN; Skliankina, OA; Varfolomeev, SD; Zaĭtsev, SV | 1 |
| Bertelli, GM; Borea, PA; Gilli, G | 1 |
| Cicero, TJ; Nock, B; O'Connor, LH; Rajpara, A | 1 |
| Law, PY; Loh, HH; Louie, AK; Zhan, JN | 1 |
| Bhargava, HN; Rapaka, RS; Renugopalakrishnan, V | 1 |
| Barnard, EA; Demoliou-Mason, CD; Wong, YH | 1 |
| Costa, T; Herz, A; Kamiya, H; Shimohigashi, Y; Stammer, CH; Takano, Y | 1 |
| Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Butler, SJ; Guild, SB; Kelly, EC; McKenzie, FR; Milligan, G; Wakelam, MJ | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Higgins, WJ; O'Neill, JB; Pert, CB; Ruff, MR; Smith, CC; Zipser, B | 1 |
| Martynova, EA; Medvedev, OS | 1 |
| Duman, RS; Nestler, EJ; Tallman, JF | 1 |
| Aliab'eva, TN; Balashov, AM; Bumialis, VV; Panchenko, LF; Petrichenko, OB | 1 |
| Inturrisi, CE; Luke, MC; Pasternak, GW; Yoburn, BC | 1 |
| Fujioka, T; Inoue, F; Kuriyama, M; Sumita, S | 1 |
| Herz, A; Millan, MJ; Morris, BJ | 1 |
| Bilibin, DP; Shevelev, OA | 1 |
| Chang, LR; Law, PY; Loh, HH; Tao, PL | 1 |
| Chalazonitis, A; Chen, GG; Crain, SM; Shen, KF | 1 |
| Bodnar, RJ; Clark, JA; Cooper, ML; Pasternak, GW | 1 |
| Costa, T; Herz, A; Klinz, FJ; Vachon, L | 1 |
| Blackburn, TP; Cross, AJ; Hille, C; Slater, P | 1 |
| Costa, T; Kodama, H; Kondo, M; Shimohigashi, Y | 2 |
| Magee, AI; Milligan, G; Mullaney, I; Unson, CG | 1 |
| Adler, BA; Goodman, RR; Pasternak, GW | 2 |
| Belcheva, M; Csanady, G; Medzihradszky, K; Szucs, M; Varga, E; Wollemann, M | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 2 |
| Bunn, SJ; Livett, BG; Marley, PD | 1 |
| Su, TP | 1 |
| Goldstein, A; Herman, BH | 1 |
| Duckles, SP; Gulya, K; Hruby, VJ; Pelton, JT; Yamamura, HI | 1 |
| Deguchi, T; Yokoyama, E | 1 |
| Barr, E; Leslie, SW | 1 |
| Dodson, BA; Miller, KW | 1 |
| Mergenhagen, S; Pert, CB; Ruff, MR; Wahl, SM | 1 |
| Bicknell, RJ; Chapman, C; Leng, G | 1 |
| Duckles, S; Gulya, K; Hruby, VJ; Pelton, JT; Yamamura, HI | 1 |
| Kalivas, PW; Miller, JS; Taylor, S | 1 |
| Falke, NE; Fischer, EG; Martin, R | 1 |
| Falke, N; Martin, R | 1 |
| Cook, L; Steinfels, GF | 1 |
| Durant, PA; Yaksh, TL | 1 |
| Barnard, EA; Demoliou-Mason, CD | 3 |
| Illes, P; Ramme, D | 1 |
| Ishihara, K; Iwama, T; Satoh, M; Takagi, H | 1 |
| Gosnell, BA; Levine, AS; Morley, JE | 1 |
| Geppert, M; Illes, P; Jackisch, R | 1 |
| Buder, M; Fuder, H; Riers, HD; Rothacher, G | 1 |
| Brenner, AS; Geppert, M; Illes, P; Jackisch, R | 1 |
| Jensen, TS; Yaksh, TL | 1 |
| Pasternak, GW; Wood, PJ | 1 |
| Kirby, GC; McQueen, DS | 1 |
| Cheng, CH; Hon, WK; Ng, TB; Su, BX | 1 |
| Hisamitsu, T; Okada, M | 1 |
| Hong, J; McLamb, R; Tilson, H | 1 |
| Arndt, IP; Shcherbakova, NV; Smagin, VG; Zverkov, IV | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Corti, V; Ledda, F; Mantelli, L | 1 |
| Jhamandas, K; Marien, M | 1 |
| Keith, RA; Salama, AI | 1 |
| Castellano, C; Pavone, F | 1 |
| Anticich, TG; Baumeister, AA; Hawkins, MF; Higgins, TD; Moore, LL | 1 |
| Balboni, G; Borea, PA; Marastoni, M; Marzola, G; Salvadori, S; Tomatis, R | 1 |
| De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A | 1 |
| Benyhe, S; Borsodi, A; Hepp, J; Khan, A; Medzihradszky, K; Simon, J; Szücs, M; Wollemann, M | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; McWilliam, JR | 2 |
| Iyengar, S; Kim, HS; Wood, PL | 1 |
| Cruciani, RA; Gainer, H; Lang, MA; Pesce, GO; Rodbard, D; Russell, JT | 1 |
| d'Amato, R; Janiri, L; Zieglgänsberger, W | 1 |
| Holtzman, SG; Ukai, M | 1 |
| Arjune, D; Bodnar, RJ; Hahn, EF; Mann, PE; Pasternak, GW; Romero, MT | 1 |
| Bueno, L; Fargeas, MJ; Primi, MP | 1 |
| Goodman, SR; McLaughlin, PJ; Zagon, IS | 1 |
| Clark, JA; Houghten, R; Pasternak, GW | 1 |
| Martinez, JL; Weinberger, SB | 1 |
| Hedler, L; Schurr, C; Starke, K; Szabo, B | 1 |
| Nilekani, SP; Nuchols, PA; Oeltgen, PR; Spurrier, WA; Su, TP | 1 |
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| Nishimura, S; Pasternak, GW | 1 |
| Coscia, CJ; Pryhuber, KG; Roth, BL | 1 |
| Masukawa, LM; Prince, DA | 1 |
| Guidotti, A; Saiani, L | 1 |
| Costa, T; Krumins, SA; Munson, PJ; Rodbard, D; Shimohigashi, Y | 1 |
| Cheng, SS; Fujimoto, JM; Tseng, LF | 1 |
| Faden, AI; Feuerstein, G; Hassen, AH; Pfeiffer, A | 1 |
| Foote, RW; Maurer, R | 1 |
| Attali, B; Audigier, Y; Cros, J; Gouardères, C; Mazarguil, H | 1 |
| Flórez, J; Pazos, A | 2 |
| Faden, AI; Feuerstein, G; Kopin, IJ; Pfeiffer, A | 1 |
| Kouakou, Y; Meunier, JC; Moisand, C; Puget, A | 1 |
| Richard, JW; Sanschagrin, D; Thakur, M; Wood, PL | 1 |
| Klee, WA; Loukas, S; Nicolaou, N; Streaty, RA; Varoucha, D; Zioudrou, C | 1 |
| Johnson, N; Pasternak, GW | 1 |
| Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 1 |
| Garzon, J; Jen, MF; Lee, NM; Loh, HH | 1 |
| Rothman, R; Westfall, TC | 1 |
| Dawson, G; Lockney, MW; Scheideler, MA | 2 |
| Cermak, D; Dawson, G; Ellory, JC; McLawhon, RW | 1 |
| Burks, TF; Porreca, F | 1 |
| Boublik, JH; Clements, JA; Funder, JW; Herington, AC | 1 |
| Barrett, RW; Vaught, JL | 2 |
| Kromer, W; Netz, S; Skowronek, B; Stark, H | 1 |
| Keys, C; Loew, GH; Toll, L | 1 |
| Gintzler, AR; Hyde, D | 1 |
| Keys, C; Loew, G; Toll, L | 1 |
| Cowan, A; Holaday, JW; Robles, LE; Tortella, FC | 2 |
| Killian, A; Mack, KJ; Weyhenmeyer, JA | 1 |
| Bradbury, WM; Cooper, JR; Glasel, JA; Reese, JH; Venn, RF | 1 |
| Gioannini, TL; Hiller, JM; Itzhak, Y; Simon, EJ | 1 |
| Govoni, S; Lucchi, L; Rius, RA; Trabucchi, M; Uzumaki, H | 1 |
| Moses, MA; Snell, CR | 2 |
| Nishimura, SL; Pasternak, GW; Recht, LD | 1 |
| Faden, AI; Feuerstein, G; Hassen, AH | 1 |
| Duggan, AW; Zhao, ZQ | 1 |
| Ho, WK; Wen, HL; Wen, PY | 1 |
| Fujioka, T; Hayashi, Y; Kanaoka, Y; Kangawa, K; Matsunaga, T; Matsuo, H; Nakayama, H | 1 |
| Castellano, C; Csányl, V; Dóka, A; Oliverio, A; Puglisi-Allegra, S | 1 |
| Costa, T; Cruciani, RA; Lutz, RA; Munson, PJ; Rodbard, D | 1 |
| Barg, J; Lenoir, D; Simantov, R | 1 |
| Geary, LE; Kerchner, GA | 1 |
| Gianoulakis, C | 1 |
| Blankwater, YJ; Dzoljic, MR; Haffmans, J; Hespe, W; Ukponmwan, OE; Vincent, JE; Zijlstra, FJ | 1 |
| Clarke, G; Noble, R; Wakerley, JB | 1 |
| Bradbury, WM; Glasel, JA; Venn, RF | 1 |
| Havemann, U; Kuschinsky, K; Winkler, M | 1 |
| Petty, MA; Reid, JL; Rubin, PC | 1 |
| Bellini, C; Biondi, L; Filippi, B; Filira, F; Rocchi, R; Sarto, G | 1 |
| Iakimovskiĭ, AF; Suvorov, NF | 1 |
| Coy, DH; Dobrzańska, M; Gawronek, J; Konturek, SJ; Kwiecień, N; Oleksy, J | 1 |
| Hirst, M; Tepperman, FS | 1 |
| Gambino, MC; Petrillo, P; Tavani, A | 1 |
| Dowdall, MJ; Turner, AJ | 1 |
| Manwaring, D; Mullane, K | 1 |
| Blake, MJ; Czech, DA; Stein, EA | 1 |
| Brown, DR; Miller, RJ | 1 |
| Kromer, W; Netz, S; Schröder, P | 1 |
| Du, C; Ferré, JP; Ruckebusch, Y | 1 |
| Balakireva, NN; Beliaev, NA; Brusov, OS; Panchenko, LF | 1 |
| Mora, F; Shaw, SG; Vives, F | 1 |
| Lishmanov, IuB; Prum, IA; Slepushkin, VD | 1 |
| Amosova, EN; Iremenko, KV; Lishmanov, IuB; Slepushkin, VD | 1 |
| Mazneva, LM; Nasonov, EL; Titov, MI; Vasil'eva, EV; Vinogradov, VA | 1 |
| Elhilali, MM; Galeano, C; Jubelin, B; Ladouceur, D; Lemaire, S | 1 |
| de Groat, WC; Hisamitsu, T | 1 |
| Karpov, IuA; Samarenko, MB | 1 |
| Go, VL; Micevychi, PE; Yaksh, TL | 1 |
| Dingledine, R; Valentino, RJ | 1 |
| Agid, Y; Gacel, G; Javoy-Agid, F; Llorens, C; Malfroy, B; Morgat, JL; Roques, BP; Roy, J; Schwartz, JC | 1 |
| Adams, N; Arnold, J; Dubois, A; Shea-Donohue, PT | 1 |
| Jensen, RA; Liang, KC; Martinez, JL; McGaugh, JL; Messing, RB; Rigter, H; Vasquez, BJ | 1 |
| Brady, LS; Holtzman, SG | 2 |
| Bloom, FE; Iversen, SD; Joyce, EM; Koob, GF; Strecker, R | 1 |
| Dingledine, R | 1 |
| Forsling, ML; Iversen, LL; Lightman, SL | 1 |
| Cantalamessa, F; de Caro, G; Massi, M; Micossi, LG | 1 |
| Bernardini, GL; Clark, WG | 1 |
| Castellano, C; Filibeck, U; Melchiorri, P; Oliverio, A; Puglisi-Allegra, S | 1 |
| Giles, TD; Sander, GE | 1 |
| Herman, ZS; Siemion, IZ; Stachura, Z; Szewczuk, Z | 1 |
| Miller, AA; Saunders, IA; Wheatley, PL | 1 |
| Bottà, G; Cremaschi, D; Fedele, G; Meyer, G | 1 |
| Cucumel, K; Cupo, A | 1 |
| Jeanjean, AP; Laduron, PM; Maloteaux, JM | 1 |
| Audus, KL; Cavitt, J; Thompson, SE | 1 |
| Adachi, T; Ambo, A; Sasaki, Y | 1 |
| Chueh, SH; Liu, TY; Song, SL | 1 |
| Bocheva, A; Dimitrov, E; Ivancheva, C; Pencheva, N; Radomirov, R | 2 |
| Kudernatsch, MB; Schlösser, B; Sutor, B; ten Bruggencate, G | 1 |
| Kushner, L; Tamir, M | 1 |
| Cruciani, RA; Dvorkin, B; Klinger, HP; Makman, MH | 1 |
| Coupar, IM; Hancock, DL | 1 |
| Kozloba, MV; Slepko, NG | 1 |
| Afanas'ev, SA; Alekseeva, ED; Lishmanov, IuB | 1 |
| Doi, M; Inoue, M; Ishibe, A; Ishida, T; Murata, T; Shinozaki, H; Yasuda, M | 1 |
| Andersson, LI; Mosbach, K; Müller, R; Vlatakis, G | 1 |
| Ananthan, S; Cha, XY; Lai, J; Porreca, F; Rice, KC; Rothman, RB; Xu, H | 1 |
| Kalentchuk, V; Kozlova, M | 1 |
| Barannik, VL; Lishmanov, IuB; Maslov, LN; Ugdyzhekova, DS | 1 |
| Castanas, E; Gravanis, A; Hatzoglou, A; Margioris, AN; Zoumakis, E | 1 |
| Ingenito, AJ; Wong, SC | 1 |
| Madamba, SG; Moore, SD; Schweitzer, P; Siggins, GR | 1 |
| Kentroti, S; Kozlova, M; Vernadakis, A | 1 |
| Garzón, J; Martínez-Peña, Y; Sánchez-Blázquez, P | 1 |
| Rafferty, MF; Tam, L | 1 |
| Kaneto, H; Kawasaki, K; Maeda, M; Nakao, K; Takahashi, M | 1 |
| de Ceballos, ML; Fernandez, A; Jenner, P; Marsden, CD | 1 |
| Erikson, LJ; Evans, C; Law, PY; Loh, HH; McGinn, TM; Wick, MJ | 1 |
| Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Venier, I | 1 |
| Castro, MA; Garzón, J; Juarros, JL; Sánchez-Blázquez, P | 1 |
| Coffield, JA; Miletic, V | 1 |
| Haaseth, RC; Hruby, VJ; Matsunaga, TO; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Vanderah, T | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Broide, RS; Leslie, FM; Loughlin, SE; Smith, JA | 1 |
| Eppler, CM; Gregor, P; Imai, Y; Spivak, CE; Uhl, GR; Wang, JB | 1 |
| Ishige, K; Ito, Y; Makimura, M; Murakoshi, Y | 1 |
| Barg, J; Belcheva, M; Coscia, CJ; Levy, R; McHale, R; Vogel, Z | 1 |
| DeHaven-Hudkins, DL; Komer, KM; Mavunkel, BJ; Peterson, JA; Rzeszotarski, WJ | 1 |
| Bowen, WD; Carlisi, VJ; Hruby, VJ; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Wild, KD | 1 |
| Loh, HH; Seybold, VS; Tao, PL | 1 |
| Elliott, J; Traynor, JR | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Georgoussi, Z; Zioudrou, C | 1 |
| Gomathi, KG; Sharma, SK | 1 |
| Magyar, A; Medzihradszky, K; Rónai, AZ | 1 |
| Coupar, IM | 1 |
| Carpenter, DO; Elekes, K; Kemenes, G; Leung, M; Rózsa, KS; Salánki, J; Stefano, G | 1 |
| Pasternak, GW; Rossi, GC; Standifer, KM | 1 |
| Anzini, M; Cappelli, A; Clarke, GD; De Benedetti, PG; Mennuni, L; Menziani, MC; Sbacchi, M; Vomero, S | 1 |
| Hruby, VJ; Kovelowski, CJ; Nichols, ML; Ossipov, MH; Porreca, F | 1 |
| Carr, IC; Milligan, G; Mullaney, I | 1 |
| Billington, D; Mackinnon, KL; Zuzel, KA | 1 |
| Pacáková, V; Stulík, K; Suchánková, J | 1 |
| Chen, Z; Hedner, J; Hedner, T | 1 |
| Iakimovskiĭ, AF | 1 |
| Arrigoni, E; Avanzini, G; Formenti, A; Mancia, M; Martina, M; Taverna, S | 1 |
| Haberstock, H; Marotti, T | 1 |
| Bakogeorgou, E; Castanas, E; Hatzoglou, A | 1 |
| Casares, F; Liu, U; Stefano, GB | 1 |
| Christensen, CB; Christrup, LL; Kristensen, K; Nielsen, LC | 1 |
| Laurent, V; Salzet, M | 1 |
| Castanas, E; Hatzoglou, A; Kampa, M; Loukas, S; Martin, P; Martin, PM | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Kalinskaia, LN; Kononenko, VIa | 1 |
| Campbell, KM; Erickson, LE; Law, PY; Loh, HH; McGinn, TM | 1 |
| Taglietti, V; Toselli, M; Tosetti, P | 1 |
| Becketts, K; Bilsky, EJ; Calderon, SN; Davis, P; Flippen-Anderson, JL; Horvath, R; Kayakiri, H; Porreca, F; Rice, KC; Rothman, RB; Smith, LE; Xu, H | 1 |
| Darula, Z; Fürst, S; Gyires, K; Rónai, AZ; Tóth, G | 1 |
| Mamede Rosa, ML; Prado, WA | 1 |
| Deddish, PA; Erdös, EG; Jackman, HL; Skidgel, RA | 1 |
| Blake, AD; Bot, G; Li, S; Reisine, T | 2 |
| Rothe, KS; Stevens, CW | 1 |
| Kondrat'ev, BIu; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV | 1 |
| Mel'nik, EI; Radivoz, MI; Timoshin, SS | 1 |
| Bolling, SF; Harlow, HH; Kilgore, KS; Oeltgen, PR; Su, TP; Tramontini, NL | 1 |
| Georgoussi, Z; Merkouris, M; Milligan, G; Mullaney, I | 1 |
| Chakrabarti, S; Jin, W; Law, PY; Loh, HH; Spencer, RJ; Thayer, SA | 1 |
| Gauthier, CA; Gonzales, GR; Minor, LD; Paul, D | 1 |
| Brine, GA; Carroll, FI; Chen, C; Lai, J; Liu-Chen, LY; Lu, YF; Partilla, JS; Porreca, F; Rice, KC; Rothman, RB; Sadee, W; Xu, H | 1 |
| Kragballe, K; Nissen, JB | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Fujita, T; Kishida, T; Kotani, A; Murakami, M; Muranishi, S; Okamoto, A; Tatsumi, H; Uchiyama, T; Yamamoto, A | 1 |
| Fingerman, M; Nagabhushanam, R; Sarojini, R | 1 |
| Chan, JS; Joshi, S; Lee, JW; Wong, YH | 1 |
| Chakrabarti, S; Law, PY; Loh, HH | 1 |
| Calderon, SN; Krassnig, R; Lai, J; Matecka, D; Ni, Q; Partilla, JS; Porreca, F; Rice, KC; Rothman, RB; Schmidhammer, H; Xu, H | 1 |
| Belcheva, MM; Bohn, LM; Coscia, CJ; Ignatova, EG; Neuman, MC | 1 |
| Dersch, C; Kubota, H; McCullough, K; Pinto, J; Rice, KC; Rothman, RB | 1 |
| Castanas, E; Denizot, A; Dermitzaki, I; Gravanis, A; Hatzoglou, A; Henry, JF; Kampa, M; Margioris, AN; Oliver, C | 1 |
| Borchardt, RT; Gangwar, S; Gudmundsson, OS; Nimkar, K; Siahaan, T | 1 |
| Joshi, S; Lee, JW; Wong, YH | 1 |
| DeAntonio, I; DeFelipe, J; García-España, A; Garzón, J; Rodríguez, JR; Sánchez-Blázquez, P | 1 |
| Chen, J; Chi, ZQ; Li, GE; Pei, G; Wang, CH; Zhou, DH | 1 |
| Makarenko, TG; Sitdikov, FG | 1 |
| Gurevich, KG; Meshavkin, VK; Toropov, AV; Zozulia, AA | 1 |
| Gerfen, CR; Steiner, H | 1 |
| Bebiakova, NA; Mikhaĭlova, SD; Semushkina, TM; Sokolov, AV; Storozhakov, GI | 1 |
| Ingenito, AJ; Shen, S | 1 |
| Borchardt, RT; Gangwar, S; Gudmundsson, O; Nimkar, K; Shan, D; Siahaan, T; Wang, B; Wang, W; Zhang, H | 1 |
| Bak, A; Borchardt, RT; Friis, GJ; Gangwar, S; Gudmundsson, OS; Siahaan, TJ | 1 |
| Bak, A; Borchardt, RT; Gudmundsson, OS; Jois, SD; Siahaan, TJ; Vander Velde, DG | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| Acosta, CG; López, HS | 1 |
| Borchardt, RT | 1 |
| Boileau, G; Carpentier, M; Crine, P; Desgroseillers, L; Ghaddar, G; Marcinkiewicz, M; Ruchon, AF; Seidah, NG | 1 |
| Fournel, S; Nano, JL; Rampal, P | 1 |
| Fujita, T; Fujiwara, Y; Kishida, T; Kiso, Y; Kotani, A; Murakami, M; Muranishi, S; Okada, N; Okamoto, A; Tatsumi, H; Uchiyama, T; Yamamoto, A | 1 |
| Gyires, K; Rónai, AZ | 1 |
| Li, P; Longhurst, JC; Tjen-A-Looi, S | 1 |
| Deschamps, JR; Flippen-Anderson, JL; George, C; Hruby, VJ; Lipkowski, AW; Misicka, A | 1 |
| Brovkovych, V; Erdös, EG; Jackman, HL; Marcic, BM; Massad, MG; Sekosan, M; Tan, F | 1 |
| Fedorova, NA; Karpov, RS; Lishmanov, IuB; Maslov, LN; Sokolov, AA | 1 |
| Bocharov, EV; Borisov, YA; Dadayan, AK; Dorokhova, EM; Myasoedov, NF; Vaskovsky, BV; Zolotarev, YA | 1 |
| Bolling, SF; Haverich, A; Karck, M; Oeltgen, P; Su, TS; Tanaka, S | 1 |
| Gomma, M; Osman, AM; Saad, AH | 1 |
| Griffin, KR; Liao, Y; Wang, B; Yang, W; Zych, LA | 1 |
| Bespalova, ZhD; Lasukova, TV; Maslov, LN; Nagase, H; Oldgen, P; Rice, KK | 1 |
| Barth, T; Fanali, S; Hauzerová, L; Kasicka, V; Solínová, V | 1 |
| Afonso, C; Bellier, B; Bossée, A; Fournier, F; Lagarrigue, M; Tabet, JC | 1 |
| Chen, G; Guo, L; Jiang, Y; Lin, JM; Qiu, B; You, Z | 1 |
| Fleishman, MU; Lebedko, OA; Sazonova, EN; Timoshin, SS; Zivotova, EU | 1 |
| Bruckschwaiger, EB; Caverson, MM; Ciriello, J; McMurray, JC | 1 |
| Chen, YL; Huchital, M; Sen, D | 1 |
| Abbood, A; Herrenknecht, C; Smadja, C; Taverna, M | 1 |
| Garmaeva, DV | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
12 review(s) available for enkephalin, leucine and enkephalin, leucine-2-alanine
| Article | Year |
|---|---|
[Synthetic neuropeptides--a new direction in anesthesiology (possible mechanisms of action)].
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Neuroleptanalgesia; Neuropeptides; Receptors, Opioid | 1990 |
Classification of opioid and 5-hydroxytryptamine receptors by means of discriminative drug effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Conditioning, Classical; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Lysergic Acid Diethylamide; Narcotics; Nicotine; Piperazines; Pyrimidines; Receptors, Opioid; Receptors, Serotonin; Research Design; Tetrahydronaphthalenes | 1987 |
Multiple mu opiate receptors.
Topics: Aging; Analgesia; Animals; Autoradiography; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Morphine; Naloxone; Neurotransmitter Agents; Phylogeny; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Substance-Related Disorders; Tissue Distribution | 1986 |
The opioid system and central cardiovascular control: analysis of controversies.
Topics: Anesthesia, General; Animals; Benzomorphans; Brain; Brain Stem; Cardiovascular System; Cats; Dogs; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Morphine; Narcotics; Paraventricular Hypothalamic Nucleus; Preoptic Area; Rats; Rats, Inbred SHR; Receptors, Opioid; Respiration; Species Specificity; Swine | 1985 |
Endogenous opioids and their receptors. Evidence for involvement in the postictal effects of electroconvulsive shock.
Topics: Animals; Anticonvulsants; Autonomic Nervous System; Blood Pressure; Brain; Diprenorphine; Drug Tolerance; Electroconvulsive Therapy; Electroencephalography; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Morphine; Naloxone; Pain; Pituitary Gland; Pressoreceptors; Rats; Receptors, Opioid; Sensory Thresholds; Tritium | 1986 |
Recent studies on opioid receptors: heterogeneity and purification.
Topics: Alcohols; Animals; Brain Chemistry; Centrifugation, Density Gradient; Chromatography, Affinity; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Ethylmaleimide; Humans; Lectins; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Solubility; Tritium; Wheat Germ Agglutinins | 1986 |
Multiple morphine and enkephalin receptors: biochemical and pharmacological aspects.
Topics: Analgesia; Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Mice; Morphine; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration | 1986 |
[Dalargin--the first enkephalin analog, used in gastroenterology].
Topics: Acute Disease; Animals; Dogs; Duodenum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Humans; Intestinal Mucosa; Pancreas; Pancreatitis; Peptic Ulcer; Rats; Wound Healing | 1988 |
[Opioid hexapeptide dalargin in the pathogenetic therapy of diseases of the digestive organs].
Topics: Animals; Digestive System Diseases; Digestive System Physiological Phenomena; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Rats | 1988 |
The opioid-induced desensitization (tolerance) in neuroblastoma x glioma NG 108-15 hybrid cells: results from receptor uncoupling.
Topics: Animals; Bacterial Toxins; Carbachol; Cell Membrane; Cyclic AMP; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Mice; Naloxone; Narcotics; Neuroblastoma; Norepinephrine; Prostaglandins E; Rats; Receptors, Opioid; Virulence Factors, Bordetella | 1984 |
Opioid peptides and central control of blood pressure.
Topics: Adolescent; Adult; Animals; Blood Pressure; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Male; Naloxone; Pressoreceptors; Rabbits; Reflex | 1984 |
delta-Opioid receptor subtypes and cross-talk with mu-receptors.
Topics: Animals; Binding Sites; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
11 trial(s) available for enkephalin, leucine and enkephalin, leucine-2-alanine
| Article | Year |
|---|---|
[Dalargin in the treatment of arteriosclerosis obliterans of the lower extremities].
Topics: Adult; Arteriosclerosis Obliterans; Clinical Trials as Topic; Drug Evaluation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Leg; Middle Aged; Placebos; Sympatholytics | 1990 |
[Treatment of peptic ulcer hemorrhage with leucine enkephalin analog dalargin].
Topics: Adult; Aged; Anti-Ulcer Agents; Clinical Trials as Topic; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Middle Aged; Peptic Ulcer Hemorrhage; Stomach Ulcer; Wound Healing | 1990 |
[The effect of various types of stress-limiting therapy on the outcome of myocardial infarction].
Topics: Aged; Antioxidants; Clinical Trials as Topic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Male; Myocardial Infarction; Phosphocreatine; Piracetam; Propranolol; Sodium Oxybate; Stress, Physiological; Verapamil | 1990 |
[Receptor characteristics of the duodenal mucosa in peptic ulcer: a new approach to the individual selection of the therapy].
Topics: Adolescent; Adult; Anti-Ulcer Agents; Clinical Trials as Topic; Duodenal Ulcer; Duodenum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Intestinal Mucosa; Male; Middle Aged; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Receptors, Opioid | 1989 |
[Dalargin electrophoresis as a method of treatment in duodenal ulcer].
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Iontophoresis; Male; Middle Aged; Wound Healing | 1988 |
[Evaluation of the effectiveness of anti-ulcer preparations (dalargin, gastrocepin, solcoseryl) in the ambulatory treatment of peptic ulcer].
Topics: Actihaemyl; Adult; Aged; Ambulatory Care; Anti-Ulcer Agents; Clinical Trials as Topic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Male; Middle Aged; Parasympatholytics; Peptic Ulcer; Tissue Extracts | 1988 |
[Functioning of the pituitary-adrenal system during the vestibulo-vegetative syndrome and administration of dalargin and nalorphine].
Topics: Autonomic Nervous System Diseases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Labyrinth Diseases; Male; Nalorphine; Pituitary-Adrenal System; Syndrome; Vestibule, Labyrinth | 1987 |
[Clinical approval of dalargin--a new agent for treating peptic ulcer].
Topics: Adolescent; Adult; Anti-Ulcer Agents; Cimetidine; Clinical Trials as Topic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Injections, Intramuscular; Male; Middle Aged; Peptic Ulcer; Recurrence | 1986 |
[The synthetic peptide preparation dalargin in the treatment of peptic ulcer].
Topics: Adolescent; Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Middle Aged | 1987 |
The analgesic efficacy of intrathecal D-Ala2-D-Leu5-enkephalin in cancer patients with chronic pain.
Topics: Adult; Aged; Analgesia; Chronic Disease; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Male; Middle Aged; Morphine; Pain; Sleep Stages | 1985 |
[Clinical response to agonists of mu and beta opiate receptors in patients with ischemic heart disease: effects of D-Ala2-Leu5-Arg6-enkephalin on hemodynamics, oxygen balance and lipid spectrum of blood].
Topics: Adrenergic beta-Agonists; Anti-Arrhythmia Agents; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Hemodynamics; Humans; Injections, Intravenous; Lipoproteins; Male; Middle Aged; Myocardial Ischemia; Receptors, Opioid; Receptors, Opioid, mu | 2002 |
910 other study(ies) available for enkephalin, leucine and enkephalin, leucine-2-alanine
| Article | Year |
|---|---|
Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity.
Topics: Analgesia; Animals; Biological Assay; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Enkephalin, Leucine; Glycine; Mice; Receptors, Opioid; Seizures; Structure-Activity Relationship; Tyrosine | 1984 |
Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin.
Topics: Animals; Anions; Bile; Biological Transport; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Estrone; Hepatocytes; In Vitro Techniques; Injections, Intravenous; Liver-Specific Organic Anion Transporter 1; Oocytes; Peptides; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Xenopus laevis | 2003 |
QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design.
Topics: Algorithms; Combinatorial Chemistry Techniques; Drug Design; Humans; Hydrolysis; Models, Chemical; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Stereoisomerism | 2009 |
[The effect of synthetic enkephalins on prostaglandin synthesis and lipid peroxidation in the isolated heart during the activation of free-radical processes].
Topics: Animals; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Free Radicals; Heart; In Vitro Techniques; Lipid Peroxidation; Myocardium; Prostaglandins; Rats; Thromboxanes | 1992 |
[The contractile activity of the lymphatic microvessels and the role of opioid peptides in its regulation].
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Lymphatic System; Male; Mesentery; Muscle Contraction; Naloxone; Rats | 1992 |
Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype.
Topics: Affinity Labels; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Spinal Cord; Thiocyanates | 1992 |
Effects of [D-Ala2, D-Leu5]enkephalin and [D-Pen2, L-Pen5]enkephalin on apomorphine-induced motor activity in the mouse.
Topics: Analgesics; Animals; Apomorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Grooming; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1992 |
Characterization of opioid binding sites in rat spinal cord.
Topics: Animals; Benzomorphans; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Rats; Receptors, Opioid; Spinal Cord | 1992 |
Protection by opioid ligands against modification of the opioid receptor by a carbodiimide.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain Chemistry; Carbodiimides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Pyrrolidines; Receptors, Opioid | 1992 |
Binding capacities and affinities at mu-, delta- and kappa-opioid sites in membrane suspensions from guinea-pig brain regions.
Topics: Animals; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Analgesics; Animals; Autoradiography; Cell Line; Cell Membrane; Cholera Toxin; Electrophoresis, Polyacrylamide Gel; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Kinetics; Mice; Molecular Weight; Neuroblastoma; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1992 |
Distinct receptors for Leu- and Met-enkephalin on the metacerebral giant cell of Aplysia.
Topics: Action Potentials; Amino Acid Sequence; Animals; Aplysia; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; FMRFamide; Molecular Sequence Data; Neurons; Neuropeptides; Receptors, Opioid | 1992 |
Effects of selective opioid receptor agonists and antagonists during myocardial ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Delta and kappa opiate receptors in primary astroglial cultures. Part II: Receptor sets in cultures from various brain regions and interactions with beta-receptor activated cyclic AMP.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Animals; Astrocytes; Brain Stem; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Isoproterenol; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Further characterization of alpha N-acetyl beta-endorphin-(1-31) regulatory activity, I: Effect on opioid- and alpha 2-mediated supraspinal antinociception in mice.
Topics: Analgesia; Analgesics; Animals; beta-Endorphin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Male; Mice; Nociceptors; Pain Measurement; Peptides; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu | 1992 |
Characterization of beta-125I-endorphin cross-linked proteins in NG108-15 cell membranes. A 25-kilodalton protein with properties of delta-opioid-binding site.
Topics: 3T3 Cells; Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cross-Linking Reagents; Down-Regulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Membrane Proteins; Mice; PC12 Cells; Peptides; Receptors, Opioid | 1992 |
Binding characteristics of delta opioid receptors in different regions of the brain of young and old male rats as studied with the highly selective ligand [D-Pen2-D-Pen5] enkephalin.
Topics: Aging; Animals; Binding, Competitive; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Tissue Distribution | 1992 |
Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Imidodiphosphate; Analgesics; Animals; Brain; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Neurons; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; RNA, Messenger | 1992 |
Characterization of opioid receptors mediating stimulation of adenylate cyclase activity in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; Male; Narcotic Antagonists; Olfactory Bulb; Oligopeptides; Opioid Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1992 |
Discriminative affinity labelling of opioid receptors by enkephalin and morphiceptin analogues containing 3-nitro-2-pyridinesulphenyl-activated thiol residues.
Topics: Affinity Labels; Amino Acid Sequence; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Molecular Sequence Data; Peptides; Pyridines; Radioligand Assay; Receptors, Opioid | 1992 |
delta-Opioid receptor binding in mouse brain: evidence for heterogeneous binding sites.
Topics: Animals; Binding, Competitive; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Membranes; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1992 |
Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Adhesion Molecules; Cell Compartmentation; Cell Membrane; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fluorescent Antibody Technique; GPI-Linked Proteins; In Vitro Techniques; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peptides; Rats; Receptors, Opioid, delta | 1992 |
Opioid receptor agonists and Ca2+ modulation in human B cell lines.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; B-Lymphocytes; Benzeneacetamides; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Humans; Naloxone; Pyrrolidines; Receptors, Opioid; Signal Transduction | 1992 |
Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Bucladesine; Calcium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Ion Channel Gating; Narcotics; Neuroblastoma; Phorbol 12,13-Dibutyrate; Pyrrolidines; Receptors, Opioid, delta; Tumor Cells, Cultured | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Dopamine D1 and opioid receptor binding changes in the limbic system of sleep deprived rats.
Topics: Animals; Benzazepines; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Limbic System; Male; Mesencephalon; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Opioid; Sleep Deprivation | 1992 |
Antinociceptive properties of two alkylating derivatives of morphinone: 14 beta-(thioglycolamido)-7,8-dihydromorphinone (TAMO) and 14 beta-(bromoacetamido)-7,8-dihydromorphinone (H2BAMO).
Topics: Analgesics; Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydromorphone; Male; Mice; Mice, Inbred ICR; Opioid-Related Disorders; Receptors, Opioid; Receptors, Opioid, mu | 1992 |
[Role of enkephalins in the mechanism of anti-arrhythmia effects of adaptation in acute myocardial ischemia].
Topics: Acute Disease; Adaptation, Physiological; Animals; Cold Temperature; Enkephalin, Leucine-2-Alanine; Enkephalins; Exercise; Heart; Male; Myocardial Ischemia; Myocardium; Nucleotides, Cyclic; Rats; Rats, Wistar; Sympatholytics; Ventricular Fibrillation | 1992 |
[The effect of opioid peptides on the size of the cellular aggregates in a cell culture of rat embryonic spinal cord].
Topics: Animals; Cell Aggregation; Cell Survival; Cells, Cultured; Embryo, Mammalian; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Rats; Rats, Wistar; Spinal Cord; Time Factors | 1992 |
Dopamine receptors in the ventral pallidum regulate circling induced by opioids injected into the ventral pallidum.
Topics: Amphetamine; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Globus Pallidus; Haloperidol; Injections; Male; Parasympatholytics; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Stereotyped Behavior | 1992 |
Role of hydrolysis in the association of leu-enkephalin to peripheral blood mononucleate cells.
Topics: Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Hydrolysis; Leukocytes, Mononuclear; Phytohemagglutinins; Protease Inhibitors | 1992 |
Differential modulation by mu- and delta-opioids on baroreceptor reflex in conscious rabbits.
Topics: Animals; Blood Pressure; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Injections, Intraventricular; Kidney; Male; Naloxone; Pressoreceptors; Rabbits; Reflex; Sympathetic Nervous System | 1992 |
Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates | 1991 |
Opioid receptor selectivity reversal in deltorphin tetrapeptide analogues.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptosomes | 1991 |
Inability of an opioid antagonist lacking negative intrinsic activity to induce opioid receptor up-regulation in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Binding, Competitive; Drinking; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Sensory Thresholds; Up-Regulation | 1991 |
Characteristics of mu and delta opioid binding sites in striatal slices of morphine-tolerant and -dependent mice.
Topics: Analgesics; Animals; Binding Sites; Corpus Striatum; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; Morphine Dependence; Naloxone; Pain; Receptors, Opioid | 1991 |
Dissociation of opioid receptor upregulation and functional supersensitivity.
Topics: Analgesia; Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naltrexone; Pertussis Toxin; Receptors, Opioid; Up-Regulation; Virulence Factors, Bordetella | 1991 |
[Effects of agonists of opiate receptors on myocardial energetics of rats with hemorrhagic shock].
Topics: Adenine Nucleotides; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Myocardium; Rats; Rats, Inbred Strains; Receptors, Opioid; Shock, Hemorrhagic | 1991 |
Ontogeny and distribution of opioid receptors in the rat brainstem.
Topics: Animals; Autoradiography; Brain Stem; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Medulla Oblongata; Pons; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Involvement of mu, delta and kappa receptors in morphine-induced tolerance in the guinea pig myenteric plexus.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphine; Muscle, Smooth; Myenteric Plexus; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Rapid agonist-induced loss of 125I-beta-endorphin opioid receptor sites in NG108-15, but not SK-N-SH neuroblastoma cells.
Topics: Analgesics; Animals; beta-Endorphin; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Mice; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1991 |
[D-Ala2]deltorphin II analogs with high affinity and selectivity for delta-opioid receptor.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptosomes | 1991 |
Endogenous opioids modulate neuronal survival in the developing avian ciliary ganglion.
Topics: Animals; Animals, Newborn; Cell Survival; Chick Embryo; Chickens; Embryonic and Fetal Development; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Parasympathetic; Mesencephalon; Morphine; Nerve Degeneration; Neuromuscular Junction; Neurons; Synapses; Synaptic Transmission | 1991 |
Sleep deprivation decreases mu and delta opioid receptor binding in the rat limbic system.
Topics: Animals; Arousal; Behavior, Animal; beta-Endorphin; Brain Chemistry; Densitometry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Limbic System; Male; Membranes; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sleep Deprivation | 1991 |
[Participation of central and peripheral mu- and delta opiate receptors in anti-arrhythmia action of enkephalins].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Myocardial Infarction; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Ventricular Fibrillation | 1991 |
[Periodic and aperiodic oscillations in neuropeptide-binding receptors in cultured cells].
Topics: Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Neuropeptides; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Chronic effect of [D-Pen2,D-Pen5]enkephalin on rat brain opioid receptors.
Topics: Analgesics; Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Binding to opioid receptors of enkephalin derivatives taking alpha-helical conformation and its dimer.
Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Brain Chemistry; Cattle; Cell Membrane; Cells, Cultured; Circular Dichroism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Ligands; Lipid Bilayers; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid | 1991 |
[The opiate-binding proteins of the synaptic membranes in the rat brain].
Topics: Animals; Brain; Carrier Proteins; Cell Adhesion Molecules; Chemical Phenomena; Chemistry, Physical; Chromatography, Affinity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GPI-Linked Proteins; Indicators and Reagents; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Rats; Rats, Inbred Strains; Receptors, Opioid; Sepharose; Synaptic Membranes | 1991 |
Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes.
Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Molecular Sequence Data; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Somatostatin | 1991 |
Activation of mu opioid receptors in the pre-optic-anterior hypothalamus releases prolactin in the conscious male rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anterior Hypothalamic Nucleus; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Preoptic Area; Prolactin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Dopaminergic system mediates only delta-opiate inhibition of endogenous acetylcholine release evoked by glutamate from rat striatal slices.
Topics: Acetylcholine; Animals; Benzazepines; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Male; Morphine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Secretory Rate | 1991 |
Anterograde transport of opioid receptors in rat vagus nerves and dorsal roots of spinal nerves: pharmacology and sensitivity to sodium and guanine nucleotides.
Topics: Animals; Axonal Transport; Colchicine; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guanosine Triphosphate; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride; Spinal Nerve Roots; Vagus Nerve | 1990 |
Alpha-fluoromethylhistidine decreases the Leu-enkephalinamide- and morphine-induced corticosterone response in rats.
Topics: Animals; Body Temperature; Brain; Corticosterone; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Histamine Release; Histidine Decarboxylase; Male; Methylhistidines; Morphine; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Atrial natriuretic polypeptide secretion via selective activation of kappa-opioid receptor: role of dynorphin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzomorphans; Cells, Cultured; Diuretics; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart; Heart Atria; Kinetics; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Differential effect of intrastriatal kainic acid on the modulation of dopamine release by mu- and delta-opioid peptides: a microdialysis study.
Topics: Animals; Corpus Striatum; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Extracellular Space; Injections; Kainic Acid; Male; Rats; Rats, Inbred Strains | 1992 |
Age-related impairment of signal transduction and its correction with antioxidants.
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Signal Transduction; Synaptosomes | 1991 |
Influence of peptidase inhibitors on the apparent agonist potency of delta selective opioid peptides in vitro.
Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1991 |
Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.
Topics: Analgesia; Animals; beta-Endorphin; Cerebral Ventricles; Cholera Toxin; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Male; Mice; Morphine; Narcotics; Pain; Pertussis Toxin; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1991 |
Opiate receptors in neuronal primary cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fetus; Morphine; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Up-Regulation | 1990 |
Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Dextromethorphan; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ketamine; Locus Coeruleus; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Opioid Peptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1990 |
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors.
Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Food Deprivation; Guinea Pigs; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule | 1990 |
Effects of drugs interacting with opioid receptors during normal perfusion or ischemia and reperfusion in the isolated rat heart--an attempt to identify cardiac opioid receptor subtype(s) involved in arrhythmogenesis.
Topics: Animals; Arrhythmias, Cardiac; Benzomorphans; Coronary Disease; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Receptors, Opioid | 1990 |
The occurrence of different kappa opioid receptors (K1 and K2) in frog (Rana esculenta) brain membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ligands; Morphinans; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Dynorphin prolongs the action potential duration of mouse sensory ganglion neurons by decreasing a K+ conductance whereas the specific kappa opioid, U-50,488H does so by increasing a Ca2+ conductance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dynorphins; Electric Conductivity; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; In Vitro Techniques; Mice; Neurons; Potassium Channels; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
The occurrence and receptor specificity of endogenous opioid peptides within the pancreas and liver of the rat. Comparison with brain.
Topics: Animals; beta-Endorphin; Brain; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Immunohistochemistry; Liver; Male; Pancreas; Radioimmunoassay; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Dynorphin prolongs the action potential of mouse sensory ganglion neurons by decreasing a potassium conductance whereas another specific kappa opioid does so by increasing a calcium conductance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ganglia, Spinal; In Vitro Techniques; Mice; Narcotics; Neural Conduction; Neurons; Potassium; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
The antinociceptive role of mu- and delta-opiate receptors and their interactions in the spinal dorsal horn of cats.
Topics: Analgesics, Opioid; Animals; Cats; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ganglia, Spinal; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Characterization of opioid receptors modulating the function of capsaicin-sensitive neurons in guinea-pig atria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Benzomorphans; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Male; Morphine; Neurons; Pyrrolidines; Receptors, Opioid; Reserpine | 1990 |
Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Neurons, Afferent; Oligopeptides; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Reserpine | 1990 |
Tonic opioid inhibition of the pressor region of the rostral ventrolateral medulla of rabbits is mediated by delta receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Hemodynamics; Male; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Pressoreceptors; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice.
Topics: Analgesia; Animals; beta-Endorphin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Somatostatin | 1990 |
Opioid agonists, prostaglandin E1 and clonidine modulate non-adrenergic, non-cholinergic transmission in the mammalian heart.
Topics: Adrenergic beta-Antagonists; Alprostadil; Animals; Atrial Function; Capsaicin; Clonidine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Heart Atria; Imidazoles; In Vitro Techniques; Morphine; Myocardial Contraction; Nerve Fibers | 1990 |
Comparative studies on the effects of some enkephalin agonists on the ERG of frog and turtle.
Topics: Animals; Electroretinography; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Morphine; Naloxone; Rana ridibunda; Receptors, Opioid; Retina; Sympatholytics; Turtles | 1990 |
alpha N-acetyl derivatives of beta-endorphin-(1-31) and -(1-27) regulate the supraspinal antinociceptive activity of different opioids in mice.
Topics: Acetylation; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Pain; Structure-Activity Relationship; Tail; Time Factors | 1991 |
[Cholecystokinin-octapeptide antagonizes the central depressive effect of opioid peptides in rats].
Topics: Animals; Blood Pressure; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Injections, Spinal; Male; Rats; Sincalide | 1991 |
Enkephalin affects ion transport via the enteric nervous system in guinea-pig ileum.
Topics: Animals; Binding Sites; Biological Transport, Active; Electrochemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; In Vitro Techniques; Ions; Male; Nervous System; Tetrodotoxin | 1990 |
Tolerance to the respiratory actions of opiates: withdrawal tolerance and asymmetrical cross-tolerance.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Narcotics; Rats; Rats, Inbred Strains; Respiratory System; Substance Withdrawal Syndrome; Sufentanil | 1990 |
Agonist-selective protection of the opioid receptor-coupled G proteins from inactivation by 5'-p-fluorosulphonylbenzoyl guanosine.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Brain; Cell Membrane; Dithiothreitol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Guanosine; Guanylyl Imidodiphosphate; Iodoacetamide; Kinetics; Molecular Sequence Data; Naloxone; Rats; Receptors, Opioid | 1990 |
Activation of delta-type opioid receptors modulates the responses of cat terminal ileum to field electrical stimulation.
Topics: Acetylcholine; Animals; Atropine; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanethidine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Effects of calcium-channel blockers (CCB) on mu and delta opioid receptors in rat brain membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions.
Topics: Animals; Bradykinin; Cations, Monovalent; Cell Line; Cell Membrane; Cell-Free System; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; In Vitro Techniques; Ligands; Magnesium; Pertussis Toxin; Receptors, Opioid; Signal Transduction; Sodium; Virulence Factors, Bordetella | 1990 |
Binding of opioids to human MCF-7 breast cancer cells and their effects on growth.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estradiol; Etorphine; Female; Humans; Kinetics; Morphinans; Morphine; Receptors, Opioid; Tumor Cells, Cultured | 1990 |
Transferred nuclear Overhauser effect analyses of membrane-bound enkephalin analogues by 1H nuclear magnetic resonance: correlation between activities and membrane-bound conformations.
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrogen-Ion Concentration; Lipid Metabolism; Liposomes; Magnetic Resonance Spectroscopy; Membranes; Phospholipids; Protein Binding; Protein Conformation; Protons; Spin Labels; Structure-Activity Relationship; Time Factors | 1990 |
Stress-induced tolerance to delta receptor agonist DPDPE and selectivity of the irreversible delta-ligand, DALCE.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Restraint, Physical; Stress, Psychological | 1990 |
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA, Neoplasm; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hybrid Cells; Immune Sera; Kinetics; Mice; Molecular Sequence Data; NAD; Neuroblastoma; Oligonucleotide Probes; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, delta; RNA, Neoplasm; Signal Transduction; Virulence Factors, Bordetella | 1990 |
[Participation of agonists and antagonist of opiate receptors in the regulation of contractile activity of lymphatic microvessels of the rat mesentery].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lymphatic System; Male; Mesentery; Naloxone; Rats; Receptors, Opioid; Sympatholytics | 1990 |
[Study of xanthine oxidase activity in the brain tissue after administration of dalargin during myoplegia].
Topics: Androstane-3,17-diol; Androstanols; Anesthesia, Inhalation; Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Neuromuscular Blocking Agents; Neuromuscular Nondepolarizing Agents; Pipecuronium; Piperazines; Rats; Respiration, Artificial; Sympatholytics; Xanthine Oxidase | 1990 |
Identification of opioid-binding materials of rat brain.
Topics: Animals; Brain Chemistry; Cattle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Rats; Receptors, Opioid | 1990 |
Opioid modulation of basal intestinal fluid transport in the mouse: actions at central, but not intestinal, sites.
Topics: Analgesics; Animals; Body Fluids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraperitoneal; Intestinal Mucosa; Intestines; Levallorphan; Male; Mice; Mice, Inbred ICR; Receptors, Opioid | 1990 |
Differentiation between rat brain and mouse vas deferens delta opioid receptors.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle, Smooth; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Species Specificity; Vas Deferens | 1990 |
Pre- and postnatal development of opiate receptor subtypes in rat spinal cord.
Topics: Aging; Animals; Binding, Competitive; Diprenorphine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1990 |
Central opioid modulation of fetal cardiovascular function: role of mu- and delta-receptors.
Topics: Analysis of Variance; Animals; Brain; Cardiovascular System; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fetal Heart; Fetus; Heart Rate; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sheep | 1990 |
[The antinociceptive properties of dalargin as an agent of anesthesiologic protection].
Topics: Analgesics; Androstane-3,17-diol; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hemodynamics; Male; Muscle Relaxants, Central; Muscle Relaxation; Naloxone; Pipecuronium; Piperazines; Rats; Rats, Inbred Strains | 1990 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
Role of peripheral mu, delta and kappa opioid receptors in opioid-induced inhibition of gastrointestinal transit in rats.
Topics: Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; Male; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
[Enkephalin blockade of the stimulating effect of parathormone on adrenal cortex function].
Topics: Adrenal Cortex; Aldosterone; Animals; Calcium; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrocortisone; Male; Parathyroid Hormone; Rats | 1990 |
Preparation and opioid activities of N-methylated analogs of [D-Ala2,Leu5]enkephalin.
Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Methylation; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Opioid | 1990 |
Mu-opioid receptors mediate the inhibitory effect of opioids on dopamine-sensitive adenylate cyclase in primary cultures of rat neostriatal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzazepines; Cells, Cultured; Corpus Striatum; Dopamine; Dopamine Antagonists; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Narcotics; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
A lack of potency for the delta-opioid antagonist naltrindole after microinjection into the rostral ventrolateral medulla of rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Indoles; Male; Medulla Oblongata; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
[3H]naloxone as an opioid receptor label: analysis of binding site heterogeneity and use for determination of opioid affinities of casomorphin analogues.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Binding Sites; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Male; Molecular Sequence Data; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1990 |
Opioid agonist and antagonist antinociceptive properties of [D-Ala2,Leu5,Cys6]enkephalin: selective actions at the deltanoncomplexed site.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Hyperpolarizing action of enkephalin on neurons in the dorsal motor nucleus of the vagus, in vitro.
Topics: Action Potentials; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Medulla Oblongata; Membrane Potentials; Naloxone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vagus Nerve | 1990 |
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation | 1990 |
The modulating influence of enkephalins on the bone marrow haemopoiesis in stress.
Topics: Animals; Bone Marrow; Cell Count; Cell Differentiation; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hematopoiesis; Male; Mice; Naloxone; Phenylalanine; Restraint, Physical; Stress, Physiological; Time Factors | 1990 |
[Effects of dalargin on proliferative processes and vertical migration of cells of the corneal epithelium during stress].
Topics: Animals; Cell Division; Cell Movement; Cornea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epithelium; Male; Rats; Stress, Physiological; Sympatholytics | 1990 |
[Effect of the leucine enkephalin analog dalargin on the components of the sympathetico-adrenal system in experimental myocardial infarction].
Topics: Adrenal Medulla; Adrenergic Fibers; Animals; Catecholamines; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Male; Myocardial Infarction; Rabbits | 1990 |
[The possibility of predicting the antinociceptive effect of dalargin in the preoperative period].
Topics: Adult; Analgesics; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials, Somatosensory; Humans; Middle Aged; Pain; Preanesthetic Medication; Sensory Thresholds | 1990 |
[A new method of general anesthesia in pulmonary surgery using dalargin instead of narcotic analgesics].
Topics: Adult; Analgesics; Anesthesia, General; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Lung; Male; Middle Aged; Neuroleptanalgesia | 1990 |
[The inhibitory effect of the synthetic leu-enkephalin analog dalargin on carcinogenesis].
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Methylnitrosourea; Neoplasms, Experimental; Rats; Sympatholytics; Time Factors | 1990 |
2-substituted-N5-(2'-aminophenyl)-4-thiohydantoic acids as aminopeptidase inhibitors with pro-antinociceptive activity.
Topics: Aminopeptidases; Analgesics; Animals; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydantoins; In Vitro Techniques; Mice; Naloxone; Pain Measurement; Puromycin; Thiohydantoins | 1990 |
The metabolism of neuropeptides. Endopeptidase-24.11 in human synaptic membrane preparations hydrolyses substance P.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glycopeptides; Humans; Hydrolysis; Neprilysin; Radioimmunoassay; Spinal Cord; Substance P; Swine; Synaptic Membranes; Synaptosomes; Tissue Distribution | 1985 |
Opioid inhibition of synaptic transmission in the guinea-pig myenteric plexus.
Topics: Acetylcholine; Action Potentials; Animals; Barium; Electric Conductivity; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Guinea Pigs; Ileum; Morphine; Myenteric Plexus; Naloxone; Nicotine; Potassium; Substance P; Synaptic Transmission | 1985 |
Mu- and delta-opioid receptor-mediated epileptoid responses in morphine-dependent and non-dependent rats.
Topics: Animals; Electroencephalography; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epilepsy; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome | 1985 |
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
Topics: Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1985 |
Irreversible opiate agonists and antagonists. III. Phenylhydrazone derivatives of naloxone and oxymorphone.
Topics: Albumins; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrazones; Hydromorphone; In Vitro Techniques; Male; Naloxone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship; Tritium | 1985 |
Inhibition of dopamine-stimulated cyclic AMP efflux from rat neostriatal slices by activation of mu- and delta-opioid receptors: a permissive role for D-2 dopamine receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Corpus Striatum; Cyclic AMP; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Direct demonstration of the activation of UDP-N-acetylgalactosamine: [GM3]N-acetylgalactosaminyltransferase by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Galactosyltransferases; Glioma; Kinetics; Mice; Microsomes; N-Acetylgalactosaminyltransferases; Neuroblastoma; Phosphoproteins; Phosphorylation; Polypeptide N-acetylgalactosaminyltransferase; Protein Kinases; Rats | 1986 |
Role of adenylate cyclase in presynaptic alpha 2-adrenoceptor- and mu-opioid receptor-mediated inhibition of [3H]noradrenaline release from rat brain cortex slices.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cadmium; Calcimycin; Cerebral Cortex; Clonidine; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Norepinephrine; Phentolamine; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Rolipram | 1986 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
Peptide sequencing by using a combination of partial acid hydrolysis and fast-atom-bombardment mass spectrometry.
Topics: Amino Acid Sequence; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrochloric Acid; Hydrolysis; Mass Spectrometry; Peptides; Substance P | 1986 |
[Gastrin, gamma-endorphin and somatostatin cells of the stomach and duodenum in patients with duodenal ulcer treated with dalargin].
Topics: Adult; Chromaffin System; Duodenal Ulcer; Duodenum; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enterochromaffin Cells; gamma-Endorphin; Gastrins; Gastrointestinal Hormones; Humans; Male; Pyloric Antrum; Somatostatin | 1987 |
Oxymorphone-naltrexonazine, a mixed opiate agonist-antagonist.
Topics: Analgesia; Animals; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; Male; Mice; Mice, Inbred ICR; Naltrexone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1987 |
[Blood flow in skin wound tissue and systemic hemodynamics as affected by a collagen-dalargin complex].
Topics: Animals; Collagen; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Granulation Tissue; Hemodynamics; Male; Neovascularization, Pathologic; Rats; Wound Healing | 1987 |
Monoclonal antiidiotypic antibodies which recognized the binding site of delta receptor: fine specificity of the antiidiotypic antibodies.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epitopes; Immunoglobulin Idiotypes; Kinetics; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Neuromodulator-mediated phosphorylation of specific proteins in a neurotumor hybrid cell line (NCB-20).
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Alprostadil; Animals; Brain; Calcimycin; Colforsin; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Immunoassay; Mice; Nerve Tissue Proteins; Neuroblastoma; Neurotransmitter Agents; Phosphoproteins; Phosphorylation; Protein Kinases; Serotonin; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1988 |
Irreversible opiate agonists and antagonists. IV. Analgesic actions of 14-hydroxydihydromorphinone hydrazones.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrazones; Hydromorphone; Male; Mice; Naloxone; Oxymorphone; Receptors, Opioid; Time Factors | 1988 |
Involvement of the guanine nucleotide-binding protein, No, in the inhibitory regulation of neuronal calcium channels.
Topics: Animals; Calcium; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Homeostasis; Hybrid Cells; Ion Channels; Neuroblastoma; Neurons | 1988 |
Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures.
Topics: Action Potentials; Animals; Barium; Calcium; Cesium; Chlorides; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fetus; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Neurons, Afferent; Organ Culture Techniques; Potassium; Tetraethylammonium; Tetraethylammonium Compounds | 1988 |
Substance P release from knee joint afferent terminals: modulation by opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Afferent Pathways; Animals; Capsaicin; Cats; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Hindlimb; Joints; Narcotics; Pyrrolidines; Reference Values; Sciatic Nerve; Substance P; Sufentanil | 1988 |
Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle.
Topics: Animals; Drug Synergism; Duodenum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ferrets; Glycopeptides; Ileum; Intestines; Male; Muscle Contraction; Protease Inhibitors; Rats; Substance P; Thiorphan | 1989 |
[Effect of the synthetic Leu enkephalin dalargin on the protein and nucleic acid content of the muscles in the rainbow trout].
Topics: Animals; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Muscle Proteins; Ovum; RNA; Salmonidae; Time Factors; Trout | 1989 |
Enkephalin regulation of L-valine transport in rabbit ileum.
Topics: Animals; Biological Transport, Active; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ileum; In Vitro Techniques; Intestinal Absorption; Membrane Potentials; Rabbits; Valine | 1989 |
A novel action of morphine in the rat locus coeruleus: persistent decrease in adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Locus Coeruleus; Male; Morphine; Naloxone; Opioid-Related Disorders; Rats; Rats, Inbred Strains | 1989 |
Effect of enkephalins on cardiac output and regional blood flow in conscious dogs.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Naloxone; Organ Specificity; Oxygen; Partial Pressure; Reference Values; Regional Blood Flow; Respiration | 1989 |
[The action of an enzymatically stable Leu-enkephalin analog on the prostanoid content in the myocardium under stress- and adrenaline-induced damage].
Topics: Animals; Avoidance Learning; Conditioning, Classical; Conflict, Psychological; Drug Evaluation, Preclinical; Drug Stability; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Epoprostenol; Heart; Myocardium; Prostaglandins; Rats; Stress, Psychological; Thromboxanes | 1989 |
Chronic exposure of NG 108-15 cells to opiate agonists does not alter the amount of the guanine nucleotide-binding proteins Gi and Go.
Topics: Adenosine Diphosphate Ribose; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Hybrid Cells; Immunoblotting; Morphine; NAD; Neuroblastoma; Pertussis Toxin; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Modulation of mesolimbic dopaminergic projections by beta-endorphin in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; beta-Endorphin; Cerebral Ventricles; Corpus Striatum; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Homovanillic Acid; Injections, Intraventricular; Kinetics; Male; Morphine; Nucleus Accumbens; Rats; Rats, Inbred Strains; Reference Values; Septal Nuclei | 1989 |
Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion.
Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Infusions, Parenteral; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Reference Values; Sufentanil | 1989 |
[Function of the endogenous opioid system in hypoxic hypoxia].
Topics: Adrenal Glands; Animals; beta-Endorphin; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hypoxia; Lactates; Male; Mice; Rats; Rats, Inbred Strains | 1989 |
Opioid receptors of neuroblastoma cells are in two domains of the plasma membrane that differ in content of G proteins.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Fractionation; Cell Membrane; Centrifugation; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Enzymatic degradation of GTP and its "stable" analogues produce apparent isomerization of opioid receptors.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Thionucleotides | 1989 |
Attempts to target antitumor drugs toward opioid receptor-rich mouse tumor cells with enkephalin-ellipticinium conjugates.
Topics: Alkaloids; Animals; DNA; DNA Topoisomerases, Type II; Drug Carriers; Ellipticines; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etoposide; Fluorescence; Mice; Rats; Receptors, Opioid | 1989 |
Selective inhibitory effects of ethylketocyclazocine on reflex pathways to the external urethral sphincter of the cat.
Topics: Animals; Cats; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Urethra; Urinary Bladder; Urinary Incontinence | 1989 |
Delta and Mu receptor agonists correlate with greater depression of cardiac function than morphine sulfate in perfused rat hearts.
Topics: Animals; Cardiac Output; Cardiovascular Physiological Phenomena; Cardiovascular System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stroke Volume | 1989 |
Dermorphin inhibits micturition reflex in rats at a central site of action.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Spinal; Male; Naloxone; Oligopeptides; Opioid Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Urination | 1989 |
Alteration of opioid receptors in seizure-susceptible El mouse brain.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Mice; Receptors, Opioid; Seizures; Subcellular Fractions | 1989 |
Alternated delta and mu receptor activation: a stratagem for limiting opioid tolerance.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Infusion Pumps; Injections, Intraperitoneal; Morphine; Naloxone; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 1989 |
Opioid antagonist modulation of murine neuroblastoma: a profile of cell proliferation and opioid peptides and receptors.
Topics: Animals; Cell Division; Cell Line; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Receptors, Opioid | 1989 |
Lateralization of opioid receptors in turtle visual cortex.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Evoked Potentials, Visual; Functional Laterality; Morphine; Naloxone; Receptors, Opioid; Turtles; Visual Cortex | 1989 |
Opioids induce postural asymmetry in spinal rat: the side of the flexed limb depends upon the type of opioid agonist.
Topics: Animals; Benzomorphans; Decerebrate State; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Functional Laterality; Male; Muscles; Naloxone; Narcotics; Phenazocine; Posture; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Time Factors | 1989 |
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
Topics: Acylation; Adenylyl Cyclase Inhibitors; Analgesia; Animals; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Glioma; Hybrid Cells; Indicators and Reagents; Ligands; Male; Molecular Structure; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Neutral endopeptidase 24.11 and angiotensin converting enzyme like activity in CALLA positive and CALLA negative lymphoid cells.
Topics: Animals; Antigens, Differentiation; Antigens, Neoplasm; Antigens, Surface; B-Lymphocytes; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glycine; Humans; Hydroxylamines; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocytes; Mice; Neprilysin; Peptidyl-Dipeptidase A; T-Lymphocytes; Tumor Cells, Cultured | 1989 |
Calcium channels in vertebrate neurons. Experiments on a neuroblastoma hybrid model.
Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cadmium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Conductivity; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gadolinium; GTP-Binding Proteins; Neuroblastoma; Neurons; Norepinephrine; Tumor Cells, Cultured | 1989 |
Guanine nucleotide-mediated inhibition of opioid agonist binding. Modulatory effects of ions and of receptor occupancy.
Topics: Cell Line; Chlorides; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanine Nucleotides; Hydrolysis; Magnesium; Phosphorylation; Receptors, Opioid; Sodium; Virulence Factors, Bordetella | 1989 |
Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture.
Topics: Action Potentials; Animals; Cells, Cultured; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Mice; Potassium Channels; Receptors, Opioid | 1989 |
[Effect of opiate receptor agonists on the course of hemorrhagic shock in rats].
Topics: Acute Disease; Animals; Drug Evaluation, Preclinical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Hemorrhage; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Shock, Hemorrhagic; Time Factors | 1989 |
Regional variations in binding capacities at mu-, delta- and kappa-opioid sites in membrane suspensions from rabbit brain.
Topics: Analgesics; Animals; Benzomorphans; Binding, Competitive; Body Weight; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Membranes; Nerve Tissue Proteins; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Opioid receptor selectivity of peptide models of beta-endorphin.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
Topics: Animals; Benzomorphans; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Narcotic Antagonists; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1989 |
[Effects of opioid receptor ligands on DNA synthesis and histamine contents in the gastric mucosa and blood of white rats].
Topics: Animals; Anti-Ulcer Agents; Autoradiography; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Histamine; Ligands; Male; Naloxone; Rats; Receptors, Opioid; Spectrometry, Fluorescence | 1989 |
Magnitude of opioid dependence after continuous intrathecal infusion of mu- and delta-selective opioids in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders; Sufentanil; Time Factors | 1989 |
Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin.
Topics: Animals; Brain Chemistry; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Guinea Pigs; Hemoglobins; In Vitro Techniques; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Multi-dimensional analysis of behavior in mice treated with the delta opioid agonists DADL (D-Ala2-D-Leu5-enkephalin) and DPLPE (D-Pen2-L-Pen5-enkephalin).
Topics: Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Rotational behaviour produced by intranigral injections of bovine and human beta-casomorphins in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Injections; Male; Mitochondria; Morphine; Muscle, Smooth; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Rotation; Stereotyped Behavior; Substantia Nigra | 1989 |
Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Line; Cell Membrane; Cholera Toxin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Hybrid Cells; NAD; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1989 |
[The effect of morphine and opiate receptor agonists on arterial pressure and the bioelectrical activity of the renal nerve during stimulation of the midbrain central gray substance].
Topics: Animals; Blood Pressure; Cats; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kidney; Morphine; p-Chloroamphetamine; Pain; Periaqueductal Gray; Receptors, Opioid; Serotonin; Sympathetic Nervous System | 1989 |
Antagonism of kappa opioid mediated effects in the rat by cyclo(Leu-Gly).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Cortex; Cyclazocine; Diuresis; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Neuropeptides; Peptides, Cyclic; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1989 |
Chronic opioid antagonist treatment: assessment of receptor upregulation.
Topics: Animals; Binding, Competitive; Brain Chemistry; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Up-Regulation | 1989 |
Dermorphin gene sequence peptide with high affinity and selectivity for delta-opioid receptors.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Oligopeptides; Opioid Peptides; Protein Conformation; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes | 1989 |
Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Computer analysis of the effect of beta-endorphin and dynorphin and related compounds on opioid binding to mouse brain membrane.
Topics: Animals; beta-Endorphin; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Mice; Models, Neurological; Receptors, Opioid | 1989 |
Effect of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin on ion and amino acid transport in rabbit ileum.
Topics: Amino Acids; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ileum; In Vitro Techniques; Intestinal Mucosa; Male; Membrane Potentials; Muscle, Smooth; Naloxone; Rabbits; Valine | 1989 |
Facilitatory effects of opioids on the discharges of visceral nociceptors.
Topics: Animals; Bradykinin; Dinoprostone; Dogs; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epididymis; Evoked Potentials; Male; Morphine; Naloxone; Nociceptors; Testis | 1989 |
Evaluation of selective actions of dopamine D-1 and D-2 receptor agonists and antagonists on opioid antinociception.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dopamine Agents; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ergolines; Fentanyl; Injections, Intraventricular; Male; Mice; Narcotics; Nociceptors; Pyrrolidines; Quinpirole; Reaction Time; Receptors, Dopamine; Sufentanil; Sulpiride | 1989 |
[A comparative study of the effectiveness of regulatory peptides in acute experimental pancreatitis].
Topics: Acute Disease; Animals; Calcitonin; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Mononuclear Phagocyte System; Pancreatitis; Phagocytosis; Radionuclide Imaging; Somatostatin; Sympatholytics | 1989 |
[The effect of regulator peptides on pancreatic endocrine function in experimental acute pancreatitis].
Topics: Acute Disease; Animals; Calcitonin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Pancreas; Pancreatitis; Peptides; Rats; Somatostatin; Time Factors | 1989 |
A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site.
Topics: Animals; Autoradiography; Brain; Chlorides; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Hydromorphone; Male; Manganese; Manganese Compounds; Mathematics; Membranes; Oligopeptides; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride | 1985 |
[The effect of the peptide dalargin on wound healing].
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Rats, Inbred Strains; Wound Healing | 1989 |
[Use of a synthetic opioid for the reversal of stress-induced damage of the myocardium and gastric mucosa in severe thermal trauma].
Topics: Animals; Burns; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Heart; Heart Failure; In Vitro Techniques; Male; Models, Cardiovascular; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological | 1989 |
[Effects of several regulatory peptides on the functional activity of the pancreas in acute experimental pancreatitis].
Topics: Acute Disease; alpha-Amylases; Amidinotransferases; Animals; Calcitonin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lipase; Lipid Peroxidation; Male; Pancreas; Pancreatitis; Rats; Somatostatin; Sympatholytics; Trypsin; Xanthine Oxidase | 1989 |
[Use of synthetic analogs of enkephalins as antiatherogenic means].
Topics: Adult; Animals; Arteriosclerosis Obliterans; Cholesterol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Lactates; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Parathyroid Hormone; Rats; Rats, Inbred Strains; Sympatholytics | 1989 |
[Effects of dalargin, a synthetic analog of endogenous opioids, on functional indices of isolated rat heart in experimental toxemia in vitro].
Topics: Animals; Bacterial Toxins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Hemodynamics; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Staphylococcus aureus; Sympatholytics; Toxemia | 1989 |
[Dalargin in the prevention of acute postoperative pancreatitis].
Topics: Acute Disease; Adult; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Intraoperative Care; Male; Middle Aged; Pancreatic Diseases; Pancreatitis; Postoperative Complications; Rats; Sympatholytics | 1989 |
Affinity resins for the purification of opioid-binding materials.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Narcotics; Rats; Resins, Plant | 1989 |
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Sulfhydryl Reagents | 1989 |
Effects of opioid drugs on capsaicin-sensitive neurones in guinea-pig atria.
Topics: Animals; Capsaicin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Narcotics; Neurons, Afferent; Sympathectomy, Chemical | 1989 |
[Results of the use of dalargin electrophoresis to correct mental disorders in patients with hypertension grades I and II].
Topics: Adult; Anxiety Disorders; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Hypertension; Iontophoresis; Male; Memory Disorders; Middle Aged; Neurocognitive Disorders; Psychomotor Performance | 1989 |
Two gamma-bends in the backbone conformation of [D-Ala2]-leucine enkephalin in solution.
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Magnetic Resonance Spectroscopy; Protein Conformation; Solutions | 1989 |
[Anti-ischemic effect of the new Soviet drug dalargin].
Topics: Adult; Coronary Disease; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Extremities; Humans; Ischemia; Male; Microcirculation; Middle Aged; Sympatholytics | 1989 |
[Regulatory effects of opioid peptides on bone marrow hematopoiesis in stress].
Topics: Animals; Bone Marrow; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hematopoiesis; Hematopoietic Stem Cells; Immobilization; Male; Mice; Stress, Physiological; Sympatholytics | 1989 |
Opioid receptor desensitization in NG 108-15 cells. Differential effects of a full and a partial agonist on the opioid-dependent GTPase.
Topics: Adenylyl Cyclase Inhibitors; Cell Line; Cell Membrane; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; Hybrid Cells; Morphine; Neuroblastoma; Phosphoric Monoester Hydrolases; Receptors, Opioid | 1987 |
delta EPhe4-enkephalin analogs. Delta receptors in rat brain are different from those in mouse vas deferens.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Isomerism; Male; Mice; Muscle, Smooth; Rats; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1987 |
Affinity labeling of delta-opiate receptors using [D-Ala2,Leu5,Cys6]enkephalin. Covalent attachment via thiol-disulfide exchange.
Topics: Animals; Brain; Disulfides; Dithiothreitol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Intracellular Membranes; Iodoacetamide; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Sulfhydryl Compounds; Synaptosomes | 1987 |
Effects of structurally different (Leu5) enkephalinamides on electrically-evoked contractions of guinea pig ileum.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evaluation Studies as Topic; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Photoinactivation of the mu opioid receptor using a novel synthetic morphiceptin analog.
Topics: Affinity Labels; Animals; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Light; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Effects of beta-funaltrexamine on radiolabeled opioid binding.
Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
[Characterization of adrenal medullary opioid receptors. I. Binding of opioids to adrenal medullary opioid receptors].
Topics: Adrenal Medulla; Animals; Cattle; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; In Vitro Techniques; Metals; Morphinans; Pheochromocytoma; Receptors, Opioid; Tritium | 1987 |
[Characterization of adrenal medullary opioid receptors. II. Coupling of adrenal medullary opioid receptors to GTP binding proteins].
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenal Medulla; Animals; Cattle; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; In Vitro Techniques; Levorphanol; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1987 |
Subtraction autoradiography of opiate receptor subtypes in human brain.
Topics: Autoradiography; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Humans; Middle Aged; Naloxone; Receptors, Opioid; Subcellular Fractions | 1987 |
Selective effects of ethanol on opiate receptor subtypes in brain.
Topics: Animals; Benzomorphans; Binding, Competitive; Brain Chemistry; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; In Vitro Techniques; Limbic System; Male; Mice; Mice, Inbred C57BL; Narcotics; Oligopeptides; Receptors, Opioid | 1987 |
Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells.
Topics: Adenylyl Cyclase Inhibitors; Alprostadil; Cell Division; Cell Membrane; Cyclic AMP; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Fatty Acids, Unsaturated; Fluorescence Polarization; Kinetics; Linoleic Acid; Linoleic Acids; Naloxone; Neuroblastoma; Receptors, Opioid; Tumor Cells, Cultured | 1987 |
Autoradiographic visualization of sex differences in the pattern and density of opiate receptors in hamster hypothalamus.
Topics: Animals; Autoradiography; Binding Sites; Brain; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estrus; Female; Functional Laterality; Hypothalamus; In Vitro Techniques; Male; Mesocricetus; Naloxone; Receptors, Opioid; Sex Characteristics | 1987 |
Autoradiographic localization of delta-opioid binding sites in human sigmoid colon.
Topics: Aged; Autoradiography; Colon, Sigmoid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; In Vitro Techniques; Middle Aged; Receptors, Opioid; Receptors, Opioid, delta | 1987 |
Synthesis and binding properties to DNA and to opioid receptors of enkephalin-ellipticinium conjugates.
Topics: Alkaloids; Animals; Brain; Cell Line; DNA; Ellipticines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Oligopeptides; Rats; Receptors, Opioid | 1987 |
Differential regulation by butyrate and dibutyryl cyclic AMP of delta-opioid, alpha 2-adrenergic, and muscarinic cholinergic receptors in NCB-20 cells.
Topics: Alprostadil; Animals; Binding, Competitive; Brain; Bucladesine; Butyrates; Butyric Acid; Carbachol; Clonidine; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Phosphatidylinositols; Quinuclidinyl Benzilate; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Opioid; Receptors, Opioid, delta; Tumor Cells, Cultured | 1988 |
Evidence for disulfide bonds in membrane-bound and solubilized opioid receptors.
Topics: Adrenal Medulla; Animals; Cattle; Cell Membrane; Chromatography, Gel; Digitonin; Diprenorphine; Disulfides; Dithiothreitol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanylyl Imidodiphosphate; Hydrogen Peroxide; Kinetics; Mercaptoethanol; Molecular Weight; Receptors, Opioid; Solubility | 1988 |
Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic.
Topics: Analgesia; Animals; Autoradiography; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Haplorhini; Male; Morphinans; Nalbuphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1988 |
Interaction of U-69,593 with mu-, alpha- and kappa-opioid binding sites and its analgesic and intestinal effects in rats.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Male; Naloxone; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid | 1988 |
Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes.
Topics: Adenylate Cyclase Toxin; Alkylating Agents; Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; GTP-Binding Proteins; Intracellular Membranes; Isothiocyanates; Kinetics; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes; Virulence Factors, Bordetella | 1988 |
Experimental attempt to simulate receptor site environment. A 500-MHz 1H nuclear magnetic resonance study of enkephalin amides.
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hydrogen; Magnetic Resonance Spectroscopy; Models, Biological; Models, Molecular; Protein Conformation; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Comparison of [125I]beta-endorphin binding to rat brain and NG108-15 cells using a monoclonal antibody directed against the opioid receptor.
Topics: Animals; Antibodies, Monoclonal; beta-Endorphin; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Immunoglobulin M; In Vitro Techniques; Iodine Radioisotopes; Male; Molecular Weight; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1988 |
A comparison of microsomal and synaptic delta site binding kinetics.
Topics: Animals; Cattle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hippocampus; Kinetics; Microsomes; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes | 1986 |
Multiple sites of divalent cation modulation of delta opioid receptor binding.
Topics: Animals; Brain; Calcium; Cations, Divalent; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Magnesium; Manganese; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Adrenal medullary opioid receptors are linked to GTP-binding proteins, pertussis toxin substrates.
Topics: Adenylate Cyclase Toxin; Adrenal Medulla; Animals; Cattle; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1986 |
Varying expression of opioid receptors and GTP-binding proteins in human pheochromocytomas.
Topics: Adrenal Gland Neoplasms; beta-Endorphin; Cell Membrane; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; GTP-Binding Proteins; Humans; Pheochromocytoma; Receptors, Opioid | 1986 |
Melphalan-containing N,N-dialkylenkephalin analogs as potential irreversible antagonists of the delta opioid receptor.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Melphalan; Morphine; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1986 |
Characterization of D-Ala2,Leu5,Cys6-enkephalin: a novel synthetic opioid peptide with slowed dissociation from delta receptors.
Topics: Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Opiate receptor binding and behavioral effects of morphine in RHA/Verh and RLA/Verh rats.
Topics: Animals; Body Temperature; Cell Membrane; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Motor Activity; Pain; Rats; Rats, Mutant Strains; Receptors, Opioid; Species Specificity | 1986 |
Pertussis toxin abolishes the antinociception mediated by opioid receptors in rat spinal cord.
Topics: Adenosine Diphosphate; Analgesics; Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Membranes; Nociceptors; Pertussis Toxin; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Ribose; Spinal Cord; Virulence Factors, Bordetella | 1987 |
Synthesis, receptor binding activity and fluorescence property of fluorescent enkephalin analogs containing L-1-pyrenylalanine.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Membranes; Molecular Conformation; Pyrenes; Rats; Receptors, Opioid; Spectrometry, Fluorescence | 1987 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
[Role of the peripheral catecholaminergic systems in the antistress action of neuropeptides].
Topics: Adrenal Medulla; Adrenergic Fibers; Animals; Catecholamines; Drug Evaluation, Preclinical; Dura Mater; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Neuropeptides; Rats; Receptors, Adrenergic; Receptors, Catecholamine; Restraint, Physical; Stress, Psychological; Time Factors | 1988 |
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.
Topics: Acetamides; Analgesics; Animals; Binding, Competitive; Cyclohexylamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Models, Molecular; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1988 |
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Molecular; Morphine; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 1988 |
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
Topics: Adenosine Diphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Antibodies; Blood; Cattle; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Pertussis Toxin; Phosphoric Monoester Hydrolases; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1988 |
Monoclonal anti-idiotypic antibodies to opioid receptors.
Topics: Animals; Antibodies, Monoclonal; Antigens; beta-Endorphin; Brain; Cell Membrane; Cyclic AMP; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybridomas; Immunoglobulin G; Immunoglobulin Idiotypes; Immunoglobulin M; Immunosorbent Techniques; Mice; Mice, Inbred BALB C; Naloxone; Rats; Receptors, Opioid; Tumor Cells, Cultured | 1988 |
[Physico-chemical study of the heterogeneous population of opioid receptors].
Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Ligands; Male; Models, Biological; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Software | 1988 |
Opiate mechanisms in the central amygdala and gastric stress pathology in rats.
Topics: Amygdala; Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Microinjections; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Restraint, Physical; Stomach Ulcer; Stress, Physiological | 1988 |
Enhancement of [3H]DAGO1 binding to rat brain by low concentrations of monovalent cations.
Topics: Animals; Batrachotoxins; Benzomorphans; Brain Chemistry; Cations, Monovalent; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanine Nucleotides; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Naloxone; Rats; Receptors, Opioid; Temperature | 1987 |
LY164929: a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Membranes; Models, Biological; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Relation of diltiazem binding sites to opioid receptor subtypes in the guinea-pig brain.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Diltiazem; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Naloxone; Radioligand Assay; Receptors, Opioid | 1987 |
[A kinetic model of the interaction of stable GTP analogs with a system of opioid receptors].
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Ligands; Male; Models, Biological; Morphine; Naloxone; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Temperature dependence of the binding of mu, delta and kappa agonists to the opiate receptors in guinea-pig brain.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Temperature | 1988 |
[3H]U-69593 labels a subtype of kappa opiate receptor with characteristics different from that labeled by [3H]ethylketocyclazocine.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride; Temperature; Tritium | 1988 |
Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Acid Phosphatase; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanfacine; Guanidines; Hybrid Cells; Neuroblastoma; Phenylacetates; Receptors, Opioid | 1988 |
Effect of ethanol on the binding of conformationally rigid and labile ligands of opioid receptors to rat brain membranes.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; In Vitro Techniques; Male; Naltrexone; Oligopeptides; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes.
Topics: Adenosine Diphosphate Ribose; Animals; Brain; Cell Membrane; Digitonin; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Naloxone; Oligopeptides; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Solubility; Virulence Factors, Bordetella | 1988 |
A highly selective ligand for brain delta opiate receptors, a cyclopropyl(E)Phe(4)-enkephalin analog, suppresses mu receptor-mediated thermal analgesia by morphine.
Topics: Analgesia; Animals; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hot Temperature; Injections, Intraventricular; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values | 1988 |
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1988 |
Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins.
Topics: Animals; Blood; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Pertussis Toxin; Rats; Receptors, Opioid; Suramin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Binding kinetics of delta opioid receptors differ for microsomal and synaptic sites.
Topics: Animals; Cattle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hippocampus; In Vitro Techniques; Kinetics; Magnesium; Manganese; Microsomes; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Synapses | 1988 |
Identification and characterization of the opiate receptor in the ciliated protozoan, Tetrahymena.
Topics: Animals; Binding, Competitive; Chemotaxis; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Molecular Weight; Peptide Mapping; Rats; Rats, Inbred Strains; Receptors, Opioid; Tetrahymena | 1988 |
[Effect of opioid peptides on regional hemodynamics in waking rats].
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Injections, Intravenous; Male; Microspheres; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Regional Blood Flow; Wakefulness | 1988 |
Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Locus Coeruleus; Male; Morphine; Narcotics; Neurons; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors; Virulence Factors, Bordetella | 1988 |
[Specific binding of mu- and delta-ligands by opiate receptors in the rat brain in the presence of reaferon].
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; In Vitro Techniques; Interferon alpha-2; Interferon Type I; Interferon-alpha; Ligands; Male; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Proteins | 1988 |
Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Reconstitution of partially purified opioid receptors with a GTP-binding protein.
Topics: Animals; Binding, Competitive; Brain; Cattle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Kinetics; Rats; Receptors, Opioid | 1988 |
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
Topics: Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Antagonist-induced opioid receptor up-regulation. II. Regionally specific modulation of mu, delta and kappa binding sites in rat brain revealed by quantitative autoradiography.
Topics: Animals; Autoradiography; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substantia Nigra | 1988 |
[Participation of the opioid-ergic system in the regulation of afferent reactions of the damaged myocardium].
Topics: Animals; Bradykinin; Butorphanol; Cats; Electrocardiography; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Heart Conduction System; Myocardial Infarction; Naloxone; Neurons, Afferent; Receptors, Opioid | 1988 |
Decrease in delta-opioid receptor density in rat brain after chronic [D-Ala2,D-Leu5]enkephalin treatment.
Topics: Animals; Brain; Diprenorphine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Time Factors | 1988 |
Inhibitor of cyclic AMP-dependent protein kinase blocks opioid-induced prolongation of the action potential of mouse sensory ganglion neurons in dissociated cell cultures.
Topics: Action Potentials; Animals; Carrier Proteins; Cells, Cultured; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Intracellular Signaling Peptides and Proteins; Mice; Neurons, Afferent; Protein Kinases | 1988 |
Loss of striatal mu1 opiate binding by substantia nigra lesions in the rat.
Topics: Animals; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Substantia Nigra | 1988 |
Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Naltrexone; Pertussis Toxin; Protein Binding; Receptors, Opioid; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1988 |
Autoradiographic localization of delta opiate receptors in rat and human brain.
Topics: Animals; Autoradiography; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Synthesis and receptor binding characteristics of [D-Ala2, cysteamine 5] enkephalin, a thiol-containing probe for structural elements of opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Kinetics; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.
Topics: Bucladesine; Cell Differentiation; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; GTP-Binding Proteins; Hybrid Cells; Neuroblastoma; Time Factors | 1988 |
Quantitative autoradiographic distribution of meptazinol-sensitive binding sites in rat brain.
Topics: Analgesics; Autoradiography; Azepines; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Meptazinol; Receptors, Opioid | 1988 |
Enkephalin photoaffinity probes: synthesis and binding properties.
Topics: Affinity Labels; Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Kinetics; Naloxone; Rats; Receptors, Opioid; Structure-Activity Relationship; Ultraviolet Rays | 1988 |
Involvement of Mu receptors in the opioid-induced increase in the turnover of mouse brain histamine.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Histamine; Male; Methylhistamines; Methylhistidines; Mice; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu; Tetrodotoxin | 1988 |
The distribution of opioid binding subtypes in the bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Benzomorphans; Cattle; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Binding Sites; Brain; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Levallorphan; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1985 |
Antinociception and paralysis induced by intrathecal dynorphin A.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Motor Activity; Naloxone; Nociceptors; Paralysis; Rats; Rats, Inbred Strains | 1985 |
Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hormones; Naloxone; Protein Conformation; Rats; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin; Structure-Activity Relationship; Synaptosomes | 1985 |
Monoclonal antibody to enkephalins with binding characteristics similar to opiate receptor.
Topics: alpha-Endorphin; Animals; Antibodies, Monoclonal; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Mice; Morphine; Naloxone; Receptors, Opioid | 1985 |
Opioid peptides increase calcium uptake by synaptosomes from brain regions.
Topics: Animals; beta-Endorphin; Brain; Calcium; Corpus Striatum; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Hippocampus; In Vitro Techniques; Peptide Fragments; Rats; Synaptosomes | 1985 |
Evidence for a dual mechanism in the anesthetic action of an opioid peptide.
Topics: 1-Octanol; Analgesics, Opioid; Anesthetics; Animals; Atmospheric Pressure; Azocines; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lipids; Naloxone; Narcotic Antagonists; Octanols; Postural Balance; Rana pipiens; Receptors, Opioid; Reflex; Solubility; Time Factors | 1985 |
Opiate receptor-mediated chemotaxis of human monocytes.
Topics: beta-Endorphin; Chemotaxis; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Humans; In Vitro Techniques; Monocytes; Peptide Fragments; Receptors, Opioid | 1985 |
Effects of opioid agonists and antagonists on oxytocin and vasopressin release in vitro.
Topics: Animals; Arginine Vasopressin; Benzomorphans; beta-Endorphin; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains | 1985 |
Somatostatin analogs with affinity for opiate receptors in rat brain binding assay.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Somatostatin; Structure-Activity Relationship | 1985 |
Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. I. Behavioral characterization.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Administration Schedule; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Microinjections; Motor Activity; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Tegmentum Mesencephali | 1985 |
Stereospecific opiate binding in living human polymorphonuclear leucocytes.
Topics: Analgesics, Opioid; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Granulocytes; Humans; Kinetics; Naloxone; Neutrophils; Receptors, Opioid | 1985 |
Opioid binding in a rat neurohypophysial fraction enriched in oxytocin and vasopressin nerve endings.
Topics: Animals; Arginine Vasopressin; Binding Sites; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats | 1985 |
Antinociceptive profiles of opioid peptide agonists in a rat tooth pulp stimulation procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dental Pulp; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Pain; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains | 1985 |
Epidural injections of bupivacaine, morphine, fentanyl, lofentanil, and DADL in chronically implanted rats: a pharmacologic and pathologic study.
Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Bupivacaine; Catheterization; Catheters, Indwelling; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epidural Space; Fentanyl; Male; Morphine; Motor Activity; Naloxone; Rats; Rats, Inbred Strains; Reaction Time; Time Factors | 1986 |
Characterization of opioid receptor subtypes in solution.
Topics: Animals; Brain; Cations; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Guanylyl Imidodiphosphate; Iodoacetamide; Kinetics; Magnesium; Naloxone; Rats; Receptors, Opioid; Sodium; Solutions | 1986 |
Differential effect of stimulation strength in mouse vas deferens on inhibition of neuroeffector transmission by receptor type selective opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cyclazocine; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Morphine Derivatives; Muscle, Smooth; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Synaptic Transmission | 1986 |
Different effects of dynorphin A on in vitro guinea pig hippocampal CA3 pyramidal cells with various degrees of paired-pulse facilitation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 1986 |
Opioid-induced feeding: localization of sensitive brain sites.
Topics: Animals; beta-Endorphin; Brain Mapping; Corpus Striatum; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Hypothalamus; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Stimulation, Chemical | 1986 |
Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit.
Topics: Animals; Benzomorphans; Clonidine; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hippocampus; Morphine; Norepinephrine; Rabbits; Receptors, Opioid | 1986 |
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Presynaptic opioid receptors modulating acetylcholine release in the hippocampus of the rabbit.
Topics: Acetylcholine; Animals; Benzomorphans; Choline; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Naloxone; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Comparison of the antinociceptive action of mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique.
Topics: Analgesics, Opioid; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Medulla Oblongata; Morphine; Naloxone; Oligopeptides; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sufentanil | 1986 |
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hypercapnia; Hypoxia; Peptide Fragments; Receptors, Opioid | 1986 |
Evidence for the presence of adrenocorticotropic and opiate-like hormones in the brains of two sea snakes, Hydrophis cyanocinctus and Lapemis hardwickii.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; beta-Endorphin; Biological Assay; Brain; Brain Chemistry; Corticosterone; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Lipolysis; Male; Melanocyte-Stimulating Hormones; Snakes; Tissue Extracts | 1986 |
[Effects of opiate and opioid peptides administered intrathecally on the pain threshold and micturition reflex in rats].
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Injections, Spinal; Morphine; Pain; Rats; Rats, Inbred Strains; Reflex; Sensory Thresholds; Urination | 1986 |
Behavioral effects of centrally administered dynorphin and [D-ala2-D-leu] enkephalin (DADLE) in rats.
Topics: Acoustic Stimulation; Animals; Avoidance Learning; Cerebral Ventricles; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hot Temperature; Injections, Intraventricular; Male; Motor Activity; Pain; Rats; Rats, Inbred F344; Reflex, Startle | 1986 |
[Gastrointestinal endocrine cells during the treatment of duodenal ulcer patients with the new peptide preparation dalargin].
Topics: Anti-Ulcer Agents; APUD Cells; Biopsy; Digestive System; Drug Evaluation; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
On the presence of opioid receptors in guinea-pig ventricular tissue.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Heart; Hydroxydopamines; In Vitro Techniques; Myocardium; Naloxone; Narcotics; Norepinephrine; Oxidopamine; Peptide Fragments; Protease Inhibitors; Receptors, Opioid; Sympathetic Nervous System | 1987 |
Glutamate-evoked release of endogenous brain dopamine: inhibition by an excitatory amino acid antagonist and an enkephalin analogue.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Nomifensine; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Tetrodotoxin | 1987 |
Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Haloperidol; Histamine; Histidine Decarboxylase; Ketamine; Male; Methylhistidines; Mice; Naloxone; Pargyline; Phenazocine; Phencyclidine; Receptors, Opioid | 1987 |
Inhibition of presynaptic alpha-2-adrenoceptor and opioid receptor agonist responses in the rat vas deferens by chronic imipramine treatment.
Topics: Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Imipramine; In Vitro Techniques; Male; Muscle, Smooth; Norepinephrine; Parasympathomimetics; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin; Vas Deferens | 1987 |
Dose- and strain-dependent effects of dermorphin and [D-Ala2-D-Leu5]enkephalin on passive avoidance behavior in mice.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Opioid; Species Specificity | 1985 |
Bilateral intranigral microinjection of morphine and opioid peptides produces antinociception in rats.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Microinjections; Morphine; Naloxone; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time; Substantia Nigra | 1987 |
Synthesis and activity profiles of new dermorphin-(1-4) peptide analogues.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Mice; Oligopeptides; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 1987 |
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Purification of a kappa-opioid receptor subtype from frog brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Chromatography, Gel; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Membranes; Molecular Weight; Naloxone; Peptide Fragments; Pyrrolidines; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa; Solubility | 1987 |
Synaptosomal free [Ca2+] is reduced by clonidine and dynorphin A-(1-13) and increased by idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Calcium; Clonidine; Dioxanes; Dioxins; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; In Vitro Techniques; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Synaptosomes | 1987 |
Mutual antagonism of kappa-opiate and alpha 2-adrenoceptor agonist effects on intrasynaptosomal free [Ca2+]i.
Topics: Aminoquinolines; Animals; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fluorescent Dyes; Idazoxan; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes | 1988 |
Mu-, delta-, kappa- and epsilon-opioid receptor modulation of the hypothalamic-pituitary-adrenocortical (HPA) axis: subchronic tolerance studies of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Opioid receptors of bovine posterior pituitary neurosecretosomes are exclusively kappa.
Topics: Analgesics, Opioid; Animals; Cattle; Cyclazocine; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Kinetics; Morphinans; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Dynorphin1-17 reduces the inhibitory actions of mu- and delta-selective opioid agonists in cortical neurons of the rat in vivo.
Topics: Animals; Cerebral Cortex; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Neural Inhibition; Neurons; Rats; Rats, Inbred Strains | 1988 |
Morphine-like discriminative stimulus effects of opioid peptides: possible modulatory role of D-Ala2-D-Leu5-enkephalin (DADL) and dynorphin A (1-13).
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Peptide Fragments; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Differential sensitivity of opioid-induced feeding to naloxone and naloxonazine.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Eating; Electroshock; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains | 1988 |
Central mu, delta- and kappa-opioid influences on intestinal water and electrolyte transport in dogs.
Topics: Animals; Body Water; Cerebral Ventricles; Cholera Toxin; Dogs; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Intestinal Absorption; Potassium; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sodium; Vagotomy | 1988 |
Characterization of opioid binding sites in murine neuroblastoma.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Clone Cells; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Kinetics; Ligands; Mice; Neuroblastoma; Receptors, Opioid | 1988 |
Opiate binding in calf thalamic membranes: a selective mu 1 binding assay.
Topics: Animals; Cattle; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus | 1988 |
Characterization of hydrolysis of [leu]enkephalin and D-ala2-[L-leu]enkephalin in rat plasma.
Topics: Aminopeptidases; Animals; CD13 Antigens; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Half-Life; Hydrolysis; Leucine; Male; Neprilysin; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Strains; Thiorphan | 1988 |
Peripheral sympatho-inhibitory cardiovascular effects of opioid peptides in anaesthetized rabbits.
Topics: Animals; Decerebrate State; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hemodynamics; Levallorphan; Male; Naloxone; Norepinephrine; Pentobarbital; Quaternary Ammonium Compounds; Rabbits; Sympathetic Nervous System | 1988 |
Further studies on opioids and hibernation: delta opioid receptor ligand selectively induced hibernation in summer-active ground squirrels.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hibernation; Male; Morphine; Peptides; Proteins; Receptors, Opioid; Receptors, Opioid, delta; Reference Values; Sciuridae; Seasons; Structure-Activity Relationship | 1988 |
[The effect of the opioid peptide dalargin on the regeneration of the rat sciatic nerve].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Nerve Regeneration; Rats; Sciatic Nerve | 1989 |
Differential alterations in opioid analgesia following neonatal monosodium glutamate treatment.
Topics: Analgesia; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Brain Chemistry; Dose-Response Relationship, Drug; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Glutamates; Immunoenzyme Techniques; Nerve Degeneration; Rats; Rats, Inbred Strains; Reflex; Sodium Glutamate | 1985 |
Selective potentiations in opioid analgesia following scopolamine pretreatment.
Topics: Animals; beta-Endorphin; Drug Synergism; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Rats; Rats, Inbred Strains; Scopolamine | 1986 |
Beta-endorphin modulation of mitogen-stimulated calcium uptake by rat thymocytes.
Topics: Animals; beta-Endorphin; Calcium; Concanavalin A; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Male; Mitogens; Phytohemagglutinins; Rats; Rats, Inbred Strains; T-Lymphocytes | 1987 |
[Comparative effect of opioid receptor ligands on cell division in the epithelium of the tongue in white rats].
Topics: Animals; beta-Endorphin; Cell Division; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Rats; Tongue | 1987 |
[Role of opioid peptides in the neurotrophic control of the acetylcholine-sensitive membrane of rat skeletal muscle fibers].
Topics: Acetylcholine; Animals; beta-Endorphin; Diaphragm; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Muscle Denervation; Muscles; Rats; Synaptic Membranes | 1987 |
Applications of ammonium formate-catalytic transfer hydrogenation. Part V (1). Transfer hydrogenolysis of peptides containing p-chlorophenylalanine as a convenient method for preparation of deuterium labeled peptides.
Topics: Deuterium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fenclonine; Formates; Hydrogenation; Indicators and Reagents; Isotope Labeling; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oligopeptides | 1987 |
Beta-endorphin-(1-27) antagonizes beta-endorphin- but not morphine-, D-Pen2-D-Pen5-enkephalin- and U50, 488H-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Peptide Fragments; Pyrrolidines; Reaction Time | 1988 |
Melphalan potently substitutes the N-terminal Tyr of D-Ala2-Leu5-enkephalin methyl ester.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Melphalan; Naloxone; Rats; Receptors, Opioid | 1985 |
Opioid effects on plasma concentrations of luteinizing hormone and prolactin in the adult male rhesus monkey.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Macaca mulatta; Male; Morphine; Naloxone; Prolactin; Receptors, Opioid | 1985 |
Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms.
Topics: Analgesia; Animals; Blood Gas Analysis; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Respiration | 1985 |
Purification and characterization of the mu opiate receptor from rat brain using affinity chromatography.
Topics: Animals; Brain Chemistry; Cholic Acids; Chromatography, Affinity; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Kinetics; Male; Molecular Weight; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1985 |
Multiple affinity states of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Opiate agonist association rate is a function of receptor occupancy.
Topics: Animals; Binding, Competitive; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Magnesium; Neuroblastoma; Receptors, Opioid; Sodium | 1985 |
Differential ontogeny of multiple opioid receptors (mu, delta, and kappa).
Topics: Animals; Animals, Newborn; Brain; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1985 |
Tolerance and cross-tolerance to the antisecretory effects of enkephalins on the guinea-pig ileal mucosa.
Topics: Animals; Biological Transport; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Guinea Pigs; Ileum; Intestinal Mucosa; Narcotic Antagonists; Receptors, Opioid | 1985 |
TENA, a selective kappa opioid receptor antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
Opiate receptor binding profile in the rabbit cerebellum and brain membranes.
Topics: Animals; beta-Endorphin; Binding Sites; Binding, Competitive; Brain; Cerebellum; Cold Temperature; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Rabbits; Receptors, Opioid; Sodium; Tritium | 1985 |
Differentiating aspects of opioid receptor binding by [3H](-) (1R,5R,9R,2''S)-5,9-dimethyl-2-tetrahydrofurfuryl-2'-hydroxy-6,7- benzomorphan hydrochloride ([3H]Mr 2034), a drug preferentially acting on kappa-receptors.
Topics: Animals; Benzomorphans; Binding, Competitive; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15).
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Kinetics; Membranes; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
[Selectivity of [D-Ala2-O-benzyl-Ser5]-enkephalin on mu and delta opiate receptor subtypes].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Detection and characterization of four binding sites for opioids in the mouse brain.
Topics: Animals; Binding Sites; Brain Chemistry; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Models, Biological; Naloxone; Receptors, Opioid; Software; Tritium | 1985 |
[The nature of cation-binding groups in binding sites for [[3H]Tyr1, D-Ala2, D-Leu5]enkephalin].
Topics: Animals; Binding Sites; Brain; Cations; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Kinetics; Membranes; Metals; Rats; Receptors, Opioid | 1985 |
Comparative studies of the binding of dimeric and monomeric enkephalins to neuroblastoma-glioma NG108-15 cells.
Topics: Animals; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Neuroblastoma; Receptors, Opioid; Tritium | 1985 |
Increased affinity of dimeric enkephalins is not dependent on receptor density.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Kinetics; Models, Neurological; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Desensitization of opioid-stimulated GTPase in neuroblastoma x glioma hybrid cells.
Topics: Animals; Drug Resistance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; Hybrid Cells; Kinetics; Magnesium; Membranes; Neuroblastoma; Neuroglia; Phosphoric Monoester Hydrolases; Rats; Sodium | 1985 |
Opioid binding to rat and guinea-pig neural membranes in the presence of physiological cations at 37 degrees C.
Topics: Animals; Brain; Cations; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Male; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Temperature; Tritium | 1985 |
Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Discrimination, Psychological; Drug Synergism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Fluoxetine; Male; Morphine; Naloxone; Pain; Propylamines; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin | 1985 |
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment.
Topics: Animals; Binding, Competitive; Brain; Drug Implants; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Time Factors | 1985 |
Rabbit anti-idiotypic antibodies raised against monoclonal anti-morphine IgG block mu & delta opiate receptor sites.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Guinea Pigs; Immune Sera; Immunoglobulin G; Immunoglobulin Idiotypes; Mice; Morphine; Naloxone; Rabbits; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Behavioural effects in rats of unilateral and bilateral injections of opiate receptor agonists into the globus pallidus.
Topics: Animals; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Globus Pallidus; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Evidence for a kappa-opioid receptor on pituitary astrocytes: an autoradiographic study.
Topics: Animals; Astrocytes; Autoradiography; Binding Sites; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Pituitary Gland; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Corpus Striatum; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Feeding Behavior; Limbic System; Male; Morphine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Taste | 1985 |
[Differential method of analyzing ligand complex formation with binding centers. The detection of the superhigh-affinity binding centers of opiate ligands].
Topics: Affinity Labels; Animals; Binding Sites; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Ligands; Membranes; Methods; Models, Biological; Morphine; Rats; Receptors, Opioid | 1985 |
Effect of [D-Ala2,Met5]enkephalinamide and [D-Ala2,D-Leu5]enkephalin on cholinergic and noradrenergic neurotransmission in isolated atria.
Topics: Acetylcholine; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Naloxone; Norepinephrine; Rabbits; Rats; Synaptic Transmission; Tetrodotoxin | 1985 |
Beta-endorphin does not protect alkylation of opiate receptor by N-ethylmaleimide.
Topics: Alkylation; Animals; beta-Endorphin; Brain Chemistry; Detergents; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; In Vitro Techniques; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1985 |
Evidence for the epsilon-type of opioid receptor in the rat vas deferens.
Topics: Animals; Binding, Competitive; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Synergism; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Fentanyl; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens | 1985 |
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Hybrid Cells; Kinetics; Ligands; Morphine; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site.
Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; In Vitro Techniques; Isothiocyanates; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Studies on spinal opiate receptor pharmacology. III. Analgetic effects of enkephalin dimers as measured by cutaneous-thermal and visceral-chemical evoked responses.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hot Temperature; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Skin; Spinal Cord | 1985 |
Opiate binding sites in the chick, rabbit and goldfish retina.
Topics: Animals; Benzomorphans; Chickens; Dihydromorphine; Diprenorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Goldfish; Oligopeptides; Rabbits; Receptors, Opioid; Retina; Species Specificity | 1985 |
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: I. Interaction with delta and mu sites.
Topics: Adrenal Medulla; Animals; Binding Sites; Cattle; Cesium; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylmaleimide; Kinetics; Lithium; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium; Stereoisomerism | 1985 |
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: II. Interaction with kappa sites.
Topics: Adrenal Medulla; Animals; Benzomorphans; Binding Sites; Calcium; Cattle; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Ethylmaleimide; Etorphine; Guinea Pigs; Kinetics; Lithium; Manganese; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, kappa; Sodium; Stereoisomerism | 1985 |
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Kidney; Neprilysin; Organophosphorus Compounds; Protease Inhibitors; Rats; Structure-Activity Relationship | 1985 |
Immunoregulation by opioid peptides: I. Absence of classical opioid receptor on human mononuclear cells.
Topics: B-Lymphocytes; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Ligands; Monocytes; Naloxone; Receptors, Opioid; T-Lymphocytes | 1985 |
[Mechanism of the antistressor effect of D-Ala(2)-Leu(5)-Arg(6)-enkephalin].
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Crush Syndrome; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrocortisone; Male; Rats; Stress, Physiological; Thymus Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1985 |
Interactions of codeine-7,8-oxide (codeine-epoxide), as a new metabolite of codeine, with multiple opiate receptors.
Topics: Animals; Brain; Cell Membrane; Codeine; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guanosine Triphosphate; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride | 1985 |
Gamma-aminobutyric acid and benzodiazepine receptor changes induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle.
Topics: Animals; Autoradiography; Benzodiazepines; Brain; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Flunitrazepam; Hydroxydopamines; Kinetics; Muscimol; Naloxone; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spiperone; Tritium | 1985 |
Sulfonic acid enkephalin: binding specificity to rat brain opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to the opiate mu-recognition site: evidence for delta----mu binding site interactions in vitro.
Topics: Animals; Bacitracin; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Central effects of mu, delta, and kappa receptor agonists in hemorrhagic shock.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blood Pressure; Consciousness; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Hypothalamus, Anterior; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Shock, Hemorrhagic | 1985 |
Combined autoradiographic-immunocytochemical analysis of opioid receptors and opioid peptide neuronal systems in brain.
Topics: Animals; Autoradiography; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Histocytochemistry; Male; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tissue Distribution; Tritium | 1985 |
Visualization of mu1 opiate receptors in rat brain by using a computerized autoradiographic subtraction technique.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Subtraction Technique; Thalamus | 1985 |
Purification of opioid-binding materials from rat brain.
Topics: Animals; Brain Chemistry; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Molecular Weight; Rats; Receptors, Opioid | 1985 |
Regulation of ventilation and oxygen consumption by delta- and mu-opioid receptor agonists.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hydrogen-Ion Concentration; Naloxone; Oxygen; Oxygen Consumption; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration | 1985 |
Evidence for [D-Ala2,D-Leu5]enkephalin-induced supersensitivity to 5-hydroxytryptamine in a neurotumor x brain hybrid cell line (NCB-20).
Topics: Adenylyl Cyclases; Alprostadil; Animals; Brain; Brain Chemistry; Cell Line; Cholera Toxin; Clonidine; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Mice; Neuroblastoma; Receptors, Serotonin; Serotonin | 1985 |
Opiate and alpha 2-adrenoceptor responses of rat amygdaloid neurons: co-localization and interactions during withdrawal.
Topics: Amygdala; Animals; Clonidine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Iontophoresis; Male; Microelectrodes; Morphine; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
Are delta-opioid receptors involved in the regulation of food and water intake?
Topics: Animals; Benzomorphans; Drinking Behavior; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Injections, Intraperitoneal; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Regional differences in mu 1-binding of [3H][D-Ala2,D-Leu5]-enkephalin: comparisons of thalamus and cortex in the rat.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus | 1985 |
[Dalargin--a peptide preparation with cytoprotective action].
Topics: Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hemorrhage; Humans; Lymphocytes; Mice; Necrosis; Pancreas; Rats; Receptors, Opioid; Stomach Ulcer | 1985 |
[Effect of enkephalins on the peripheral effects of adrenalin].
Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Glycogen; Heart Rate; Liver Glycogen; Male; Myocardium; Parathyroid Hormone; Rats | 1985 |
A monoclonal antibody capable of modulating opioid binding to rat neural membranes.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cyclazocine; Dihydromorphine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Flunitrazepam; Immunoglobulin M; Kinetics; Male; Mice; Mice, Inbred BALB C; Molecular Weight; Naloxone; Narcotics; Nerve Tissue; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
NMB: a human neuroblastoma cell line with specific opiate binding sites.
Topics: Binding Sites; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Tritium | 1985 |
[Effect of dalargin on the content of endorphins, leucine-enkephalin ACTH and corticosterone of the blood of stressed rats].
Topics: Acute Disease; Adrenocorticotropic Hormone; Animals; Ascitic Fluid; Corticosterone; Drug Evaluation, Preclinical; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Peritonitis; Rats; Rats, Inbred Strains; Stress, Physiological; Time Factors; Toxins, Biological | 1985 |
Autoradiographic analysis of mu1, mu2, and delta opioid binding in the central nervous system of C57BL/6BY and CXBK (opioid receptor-deficient) mice.
Topics: Animals; Central Nervous System; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hybridization, Genetic; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Preparation of rat brain membranes highly enriched with opiate kappa binding sites using site-directed acylating agents: optimization of assay conditions.
Topics: Alkylating Agents; Animals; Autoradiography; Benzomorphans; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Membranes; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride | 1985 |
Characterisation of the delta-opioid receptor on the hamster vas deferens.
Topics: Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Mesocricetus; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1985 |
A radiolabeled-ligand-binding technique for the characterization of opioid receptors in the intact mouse vas deferens.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Mice; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid; Vas Deferens | 1985 |
Sex-dependent effects of neonatally administered morphiceptin and D-ala-D-leu-enkephalin on maze learning in rats.
Topics: Animals; Cerebral Ventricles; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Learning; Male; Motor Activity; Rats; Reaction Time; Receptors, Opioid; Receptors, Opioid, mu; Sex Characteristics | 1985 |
[The role of mu- and delta-opiate receptors in the realization of the autonomic effects of opioid peptides].
Topics: Animals; Autonomic Nervous System; Blood Pressure; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Mice; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration | 1986 |
A human neuroblastoma cell line expresses mu and delta opioid receptor sites.
Topics: Bone Neoplasms; Cell Line; Child, Preschool; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Guanylyl Imidodiphosphate; Humans; Kinetics; Naloxone; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Topics: Bradykinin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Hybrid Cells; Hydrolysis; Membranes; Neuroblastoma; Pertussis Toxin; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Virulence Factors, Bordetella | 1986 |
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Diprenorphine; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Etorphine; Glioma; Hybridomas; Naloxone; Neuroblastoma; Phenylisopropyladenosine; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Transcription, Genetic | 1986 |
Interaction of [3H](-)-SKF-10,047 with brain sigma receptors: characterization and autoradiographic visualization.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cell Membrane; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine Derivatives; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Tissue Distribution | 1986 |
Distinct subtypes of the opioid receptor with allosteric interactions in brain membranes.
Topics: Allosteric Site; Animals; Brain; Cations; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Kinetics; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1986 |
Subcellular compartmentation of opioid receptors: modulation by enkephalin and alkaloids.
Topics: Animals; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Chloroquine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Golgi Apparatus; Kinetics; Lysosomes; Microsomes; Neuroblastoma; Receptors, Opioid | 1986 |
Opioid peptides decrease noradrenaline release and blood pressure in the rabbit at peripheral receptors.
Topics: Animals; Blood Pressure; Catecholamines; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Male; Norepinephrine; Rabbits; Receptors, Opioid | 1986 |
Quantitative autoradiographic analysis of mu and delta opioid binding sites in the rat hippocampal formation.
Topics: Animals; Autoradiography; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Kappa-opiate binding to rat brain and guinea pig cerebellum: sensitivity towards ions and nucleotides.
Topics: Animals; Brain; Cerebellum; Cyclazocine; Electrolytes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guanine Nucleotides; Guinea Pigs; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Intrathecal D-Ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate.
Topics: Aged; Carcinoma; Clonidine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Injections, Spinal; Male; Morphine; Naloxone; Pain, Intractable; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Skull Neoplasms; Spinal Neoplasms; Substance Withdrawal Syndrome; Thyroid Neoplasms | 1986 |
Increased delta, but not mu, opiate receptor binding in the medulla oblongata of Long-Evans rats following 5-day water deprivation.
Topics: Animals; Body Weight; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors; Urination; Water Deprivation | 1986 |
Cystamine-enkephalin dimer. Syntheses and biological activities of enkephalin analogs containing cystamine and cysteamine.
Topics: Animals; Brain; Cell Membrane; Cystamine; Cysteamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 1986 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Central opioid receptors and baroreflex control of sympathetic and cardiovascular function.
Topics: Animals; Blood Pressure; Brain; Cardiovascular Physiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Heart Rate; Naloxone; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Sympathetic Nervous System | 1986 |
Subclass specificity of anti-idiotypic anti-opiate receptor antibodies in rat brain, guinea pig cerebellum, & neuroblastoma x glioma (NG 108-15).
Topics: Animals; Antibodies, Anti-Idiotypic; Binding, Competitive; Cell Line; Cerebellum; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Morphine; Neurilemma; Neurons; Rats; Receptors, Opioid | 1986 |
In vitro activity profiles of cyclic and linear enkephalin pseudopeptide analogs.
Topics: Animals; Biological Assay; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Peptides, Cyclic; Rats; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1986 |
Cyclic AMP or forskolin rapidly attenuates the depressant effects of opioids on sensory-evoked dorsal-horn responses in mouse spinal cord-ganglion explants.
Topics: Animals; Bucladesine; Colforsin; Cyclic AMP; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Mice; Morphine; Organ Culture Techniques; Spinal Cord | 1986 |
Morphine analgesia is potentiated in adult rats prenatally exposed to ethanol.
Topics: Animals; Brain; Drug Synergism; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; Female; Morphine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Is there a common, high-affinity opioid binding site in rat brain?
Topics: Animals; Binding, Competitive; Brain Chemistry; Buprenorphine; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Pentazocine; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): evidence from binding assays.
Topics: Animals; Binding, Competitive; Brain; Chromatography, Gel; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Kinetics; Male; Naloxone; Phenazocine; Phencyclidine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Traumatic injury alters opiate receptor binding in rat spinal cord.
Topics: Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Spinal Cord Injuries | 1986 |
Tyr1-substituted and fluorescent Pya1-enkephalins bind strongly and selectively to mu and delta opiate receptors.
Topics: Alanine; Animals; Binding, Competitive; Crystallography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Pyrenes; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spectrometry, Fluorescence; Structure-Activity Relationship; Tyrosine | 1986 |
Morphine tolerance increases mu-noncompetitive delta binding sites.
Topics: Animals; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Kinetics; Morphine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Stress-induced changes in the analgesic and thermic effects of opioid peptides in the rat.
Topics: Animals; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Restraint, Physical; Stress, Physiological | 1986 |
Opiate-induced seizures: a study of mu and delta specific mechanisms.
Topics: Animals; Electroencephalography; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Narcotics; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1986 |
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1986 |
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Guinea Pigs; Male; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1986 |
Interaction of dimeric and monomeric enkephalins with NG108-15 hybrid cells. A kinetic analysis.
Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hybrid Cells; Kinetics; Mice; Rats; Receptors, Opioid | 1986 |
Opioid ligand binding sites in the spinal cord of the guinea-pig.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1986 |
[Effect ot thyroliberin on rat brain opiate receptors].
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamus; Male; Mesencephalon; Rats; Receptors, Opioid; Thyrotropin-Releasing Hormone | 1986 |
Autoradiographic localization of mu- and delta-opiate receptors in the forebrain of the rat.
Topics: Amygdala; Animals; Autoradiography; Cerebral Cortex; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Diencephalon; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamus; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Telencephalon | 1986 |
Evidence from behavioural and in vitro receptor binding studies that the enkephalinergic system does not mediate acute ethanol effects.
Topics: Animals; Behavior, Animal; Body Temperature; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; In Vitro Techniques; Narcotic Antagonists; Pain; Psychomotor Performance; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1986 |
Blockade of D-2 dopamine receptors strongly enhances the potency of enkephalins to inhibit dopamine-sensitive adenylate cyclase in rat neostriatum: involvement of delta- and mu-opioid receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclase Inhibitors; Animals; Benzazepines; Corpus Striatum; Cyclic AMP; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ergolines; Male; Morphine; Naloxone; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Action at the mu receptor is sufficient to explain the supraspinal analgesic effect of opiates.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Protein Precursors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. I. Morphine-like discriminative stimulus effects.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine Dependence; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Delta opioid receptors in human neuroblastoma cell lines.
Topics: Binding, Competitive; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Differential sensitivity of basal and opioid-stimulated low Km GTPase to guanine nucleotide analogs.
Topics: Animals; Cell Line; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Phosphoric Monoester Hydrolases; Structure-Activity Relationship; Thionucleotides | 1986 |
Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Lethal Dose 50; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Time Factors | 1986 |
Opiate receptor binding characteristics of dimeric analogues of mu-selective DAGO-enkephalin.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 1986 |
[Changes in the properties of brain opiate receptors during the development of morphine tolerance in rats].
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Morphine; Morphine Dependence; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1986 |
Studies on the effects of intrathalamically injected DADL and morphine on nociceptive thresholds and electroencephalographic activity: a thalamic delta receptor syndrome.
Topics: Animals; Electroencephalography; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures; Sensory Thresholds; Thalamus | 1986 |
Corticosterone reduces the excitability of hippocampal pyramidal cells in vitro.
Topics: Animals; Corticosterone; Dexamethasone; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Interneurons; Male; Rats; Rats, Inbred Strains; Synaptic Transmission | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Activation of presynaptic alpha 2-adrenoceptors attenuates the inhibitory effect of mu-opioid receptor agonists on noradrenaline release from brain slices.
Topics: Animals; Brain Chemistry; Cadmium; Clonidine; Colforsin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu | 1986 |
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1986 |
Affinity purification of the opioid receptor in NG 108-15 cells using an avidin-biotin system with a novel elution method.
Topics: Avidin; Binding, Competitive; Biotin; Cell Line; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Receptors, Opioid; Solubility | 1986 |
Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors.
Topics: Acetylcholine; Animals; Bradykinin; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Mice; Phosphatidylinositols; Rats; Receptors, Opioid | 1986 |
[Differences in opioid binding in the left and right visual cortex of the turtle].
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Functional Laterality; Receptors, Opioid; Turtles; Visual Cortex | 1986 |
[D-Pen2,D-Pen5]enkephalin (DPDPE): a delta-selective enkephalin with low affinity for mu 1 opiate binding sites.
Topics: Animals; Brain Chemistry; Cattle; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Synthesis of four diastereomeric enkephalins incorporating cyclopropyl phenylalanine.
Topics: Animals; Binding, Competitive; Brain; Circular Dichroism; Cyclopropanes; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Male; Naloxone; Phenylalanine; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 1986 |
Autoradiographic localization in rat brain of kappa opiate binding sites labelled by [3H]bremazocine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphinans; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
[Anti-ulcer action and peripheral opioid activity of the products of dalargin degradation].
Topics: Animals; Anti-Ulcer Agents; Biotransformation; Drug Evaluation, Preclinical; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Hydrolysis; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1986 |
Continuous intrathecal opioid analgesia: tolerance and cross-tolerance of mu and delta spinal opioid receptors.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1987 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
GTPase and adenylate cyclase desensitize at different rates in NG108-15 cells.
Topics: Adenylyl Cyclase Inhibitors; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Phosphoric Monoester Hydrolases; Receptors, Opioid | 1987 |
Decreased striatal opiate delta-receptors in the rat model of persistent dyskinesia induced by iminodipropionitrile.
Topics: Animals; Corpus Striatum; Dyskinesia, Drug-Induced; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Nitriles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Audiogenic seizures during ethanol withdrawal can be blocked by a delta opioid agonist.
Topics: Acoustic Stimulation; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethanol; Female; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome | 1986 |
Morphine and enkephalins potently inhibit [3H]noradrenaline release from rat brain cortex synaptosomes: further evidence for a presynaptic localization of mu-opioid receptors.
Topics: Animals; Calcium; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptosomes; Tetrahydronaphthalenes | 1987 |
Guanine nucleotide and cation regulation of mu, delta, and kappa opioid receptor binding: evidence for differential postnatal development in rat brain.
Topics: Animals; Brain; Cations; Chlorides; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Manganese; Manganese Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1987 |
Postmortem changes in rat brain: studies on membrane-bound enzymes and receptors.
Topics: Animals; Brain; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Cell Membrane; Diazepam; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Male; Naloxone; Postmortem Changes; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Receptors, Opioid; Sodium-Potassium-Exchanging ATPase; Succinates | 1987 |
Delta receptors in the rat vas deferens.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1986 |
Opioid enhancement of perforant path transmission: effect of an enkephalin analog on inhibition and facilitation in the dentate gyrus.
Topics: Action Potentials; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hippocampus; Male; Naloxone; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptic Transmission | 1986 |
Differential ontogeny of divalent cation effects on rat brain delta-, mu-, and kappa-opioid receptor binding.
Topics: Animals; Animals, Newborn; Brain; Calcium; Cations, Divalent; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Magnesium; Manganese; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
[The use of 1H-NMR-spectroscopy for the study of peptide degradation by angiotensin-converting enzyme].
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Hydrolysis; In Vitro Techniques; Kidney; Kinetics; Magnetic Resonance Spectroscopy; Peptides; Peptidyl-Dipeptidase A | 1987 |
[The role of various opiate receptors in the regulation of the nociceptive reaction of the arterial pressure].
Topics: Animals; Benzomorphans; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Morphine; Nociceptors; Rats; Receptors, Opioid | 1987 |
[The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats].
Topics: Animals; Anti-Ulcer Agents; Brain; Cysteamine; Disease Models, Animal; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Subcutaneous; Male; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Opioid peptides. Biological study of [D-MetO2] dermorphin analogues in relation to the plurality of opioid receptors. XI.
Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Injections, Intraventricular; Male; Muscle Contraction; Receptors, Opioid | 1987 |
Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse.
Topics: Analgesia; Anesthesia, Spinal; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Coupling of adrenal medullary opioid receptors to islet-activating protein-sensitive GTP-binding proteins.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adrenal Medulla; Animals; Cattle; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1987 |
The effect of chronic imipramine and electroconvulsive shock treatment on [3H]DADLE binding to cortical membranes of rats pretreated with chronic reserpine or 6-hydroxydopamine.
Topics: Animals; Cell Membrane; Cerebral Cortex; Electroshock; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydroxydopamines; Imipramine; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Reserpine | 1987 |
Nonequilibrium opioid antagonist activity of 6,14-dideoxynaltrexone derivatives.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Inhibition of dopamine-sensitive adenylate cyclase by opioids: possible involvement of physically associated mu- and delta-opioid receptors.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Corpus Striatum; Cyclic AMP; Dopamine Antagonists; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Isoproterenol; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vasoactive Intestinal Peptide | 1987 |
Opioid receptor binding in rat spinal cord.
Topics: Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1987 |
Differential maturation of mu and delta opioid receptors in the chick embryonic brain.
Topics: Animals; Brain; Chick Embryo; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Levorphanol; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Multiple interconvertible affinity states for the delta opioid agonist-receptor complex.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes | 1987 |
Characterization of kappa opioid receptors in neurosecretosomes from bovine posterior pituitary.
Topics: Animals; Cattle; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Kinetics; Microscopy, Electron; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
N,N-dialkylated leucine enkephalins as potential delta opioid receptor antagonists.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Mice; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1987 |
Biphasic competition between opiates and enkephalins: does it indicate the existence of a common high affinity ("mu-1") binding site?
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Morphine; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Actions of opioids on the dorsal root potential of the isolated spinal cord preparation of the neonate rat.
Topics: Animals; Animals, Newborn; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Spinal Nerve Roots | 1987 |
Intracerebroventricular administration of superFIT and its enantiomer to rats: evidence for in vivo acylation of [3H]DADL binding sites.
Topics: Acylation; Animals; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Indicators and Reagents; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1987 |
[Characterization of opioid receptors in the golden hamster brain].
Topics: Animals; Binding, Competitive; Brain; Brain Chemistry; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Male; Mesocricetus; Radioligand Assay; Receptors, Opioid | 1986 |
Naloxonazine effects on the interaction of enkephalin analogs with mu-1, mu and delta opioid binding sites in rat brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
[Effect of the opiate antagonist naloxone on the electrical activity of identified neurons in the edible snail].
Topics: Animals; Benzomorphans; beta-Endorphin; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Helix, Snails; Membrane Potentials; Morphine; Naloxone; Neurons; Receptors, Opioid | 1987 |
[Alpha interferon interaction with opiate receptors in the rat brain].
Topics: Animals; Bacitracin; Brain; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Interferon Type I; Naloxone; Protein Binding; Rats; Receptors, Opioid; Tritium | 1987 |
[Opioid activity of peptides and wound healing of the skin].
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Skin; Wound Healing | 1987 |
Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Naloxone; Protein Precursors; Radioligand Assay; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Synthesis and evaluation of melphalan-containing N,N-dialkylenkephalin analogues as irreversible antagonists of the delta opioid receptor.
Topics: Alkylation; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Melphalan; Mice; Morphine; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1987 |
Modulation of human neuroblastoma transplanted into nude mice by endogenous opioid systems.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Naltrexone; Neoplasm Transplantation; Neuroblastoma; Receptors, Opioid; Transplantation, Heterologous | 1987 |
Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hippocampus; In Vitro Techniques; Male; Naloxone; Rats; Rats, Inbred Strains | 1988 |
Effect of intravenous enkephalin administration on kallikrein-kinin system in experimental hemorrhagic shock. Evidence for activation of kallikrein-kinin system by naloxone.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemorrhage; Injections, Intravenous; Kallikreins; Kinins; Male; Naloxone; Rats; Rats, Inbred Strains; Shock, Hemorrhagic | 1988 |
Cardiorespiratory effects and kinetics of intrathecally injected D-Ala2-D-Leu5-enkephalin and morphine in unanesthetized dogs.
Topics: Animals; Behavior, Animal; Carbon Dioxide; Cardiovascular System; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Spinal; Kinetics; Male; Morphine; Naloxone; Respiration | 1986 |
[Effect of dalargin on morphologic and functional indices in experimental myocardial infarct].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Myocardial Infarction; Nitroglycerin; Propranolol; Rats | 1986 |
Effect of parasympathetic blockade on ventilatory and cardiac depression induced by opioids.
Topics: Animals; Arteries; Atropine; Carbon Dioxide; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart; Heart Rate; Naloxone; Nerve Block; Parasympathetic Nervous System; Partial Pressure; Respiration | 1987 |
Modification of opioid agonist binding by pertussis toxin.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Male; Mesencephalon; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1987 |
Pertussis toxin treatment results in tolerance to the depressant effects of opioid, monoaminergic, and muscarinic agonists on dorsal-horn network responses in mouse spinal cord-ganglion cultures.
Topics: Adenylate Cyclase Toxin; Animals; Carbachol; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fetus; Ganglia, Spinal; Mice; Morphine; Norepinephrine; Organ Culture Techniques; Oxotremorine; Pertussis Toxin; Serotonin; Spinal Cord; Virulence Factors, Bordetella | 1986 |
Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism.
Topics: Animals; Bacitracin; Biological Transport; Carbon Radioisotopes; Choroid Plexus; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Kinetics; Mannitol; Sheep; Tritium | 1988 |
Monoclonal antibodies to dalargin--a synthetic analog of enkephalins.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptide Fragments | 1988 |
[Effects of opioid peptide dalargin on reparative processes in wound healing].
Topics: Administration, Topical; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fibroblasts; Granulation Tissue; Injections, Intraperitoneal; Macrophages; Male; Mitotic Index; Rats; Skin; Wound Healing | 1988 |
[The effect of methionine enkephalin, leucine enkephalin and the hexapeptide, dalargin on the morphology of cultured neurons].
Topics: Animals; Brain; Cell Division; Cells, Cultured; Chick Embryo; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Microscopy, Electron, Scanning; Neurons; Rats; Retina | 1988 |
[Experimental study of the hepatoprotective effect of transcranial transcutaneous electrostimulation and the synthetic analog of leu-enkephalin dalargin].
Topics: Animals; Brain; Electric Stimulation Therapy; Electronarcosis; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Histidine Ammonia-Lyase; Liver; Liver Diseases; Male; Rats; Transcutaneous Electric Nerve Stimulation; Urokinase-Type Plasminogen Activator | 1988 |
Effects of opioid peptides on aldosterone production: stimulatory effect of leu-enkephalin.
Topics: Adrenal Cortex; Aldosterone; Animals; Cattle; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Perfusion | 1988 |
[Effect of opioid peptides on the lymphatic drainage of the pancreas in the rat and dog].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Evans Blue; Female; Lymph; Male; Naloxone; Pancreas; Phenazocine; Rats; Rats, Inbred Strains | 1988 |
Interaction between opioid agonists or naloxone and 5-HTP on feeding behavior in food-deprived rats.
Topics: 5-Hydroxytryptophan; Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Feeding Behavior; Food Deprivation; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains | 1988 |
[Effects of opioid peptides on rats with a second heart transplanted into the abdominal cavity].
Topics: Abdomen; Animals; Cardiac Catheterization; Denervation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart; Heart Transplantation; Hemodynamics; Isoproterenol; Male; Propranolol; Rats; Rats, Inbred Strains | 1988 |
Convulsant action of morphine, [D-Ala2, D-Leu5]-enkephalin and naloxone in the rat amygdala: electroencephalographic, morphological and behavioural sequelae.
Topics: Amygdala; Animals; Brain; Convulsants; Diazepam; Drug Interactions; Electroencephalography; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Microinjections; Morphine; Naloxone; Rats; Rats, Inbred Strains | 1987 |
Enkephalin uptake into cholinergic synaptic vesicles and nerve terminals.
Topics: Acetylcholine; Animals; Electric Organ; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Morphine; Naloxone; Nerve Endings; Synaptic Vesicles; Synaptosomes; Torpedo | 1987 |
Effects of opioid agonist drugs on the in vitro release of 3H-GABA, 3H-dopamine and 3H-5HT from slices of rat globus pallidus.
Topics: Animals; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; gamma-Aminobutyric Acid; Globus Pallidus; Potassium Chloride; Rats; Rats, Inbred Strains; Serotonin | 1987 |
[Participation of leu-enkephalin in regulating carbohydrate metabolism].
Topics: Animals; Blood Glucose; C-Peptide; Carbohydrate Metabolism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Insulin; Liver Glycogen; Male; Naloxone; Parathyroid Hormone; Rats | 1987 |
DSLET (D-ser2-leu5-enkephalin-Thr6) produces analgesia on the hot plate by mechanisms largely different from DAGO and morphine-like opioids.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Mice; Mice, Inbred Strains; Oligopeptides; Species Specificity; Structure-Activity Relationship | 1987 |
Synaptic control of pyramidal cell activation in the hippocampal slice preparation in the rat.
Topics: Animals; Dendrites; Electric Stimulation; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Hippocampus; In Vitro Techniques; Narcotics; Neural Inhibition; Penicillins; Pentobarbital; Rats; Synapses | 1987 |
Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carbachol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Ganglia, Spinal; Mice; Morphine; Norepinephrine; Organ Culture Techniques; Oxotremorine; Pertussis Toxin; Serotonin; Spinal Cord; Virulence Factors, Bordetella | 1987 |
[Effect of dalargin on blood and lymph microcirculation].
Topics: Animals; Blood Cells; Cell Movement; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lymph; Lymphatic System; Male; Mesentery; Microcirculation; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Time Factors | 1988 |
[Ultrastructure of cardiomyocytes in the peri-infarct zone during the treatment of experimental myocardial infarct in rats using the hexapeptide dalargin].
Topics: Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Microscopy, Electron; Mitochondria, Heart; Myocardial Infarction; Myocardium; Rats | 1988 |
[Effect of the synthetic endogenous opioid analog dalargin on the natural cytotoxicity of human lymphocytes].
Topics: Cytotoxicity, Immunologic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; In Vitro Techniques; Lymphocytes | 1988 |
[Morphofunctional changes in the pancreas in response to dalargin under normal conditions and in experimental pancreatitis].
Topics: Acute Disease; Animals; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Pancreas; Pancreatic Juice; Pancreatitis; Rats | 1988 |
[Effect of synthetic analogs of L-enkephalin on viable areas of the pancreas in experimental pancreatitis].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Pancreas; Pancreatitis; Rats | 1988 |
Effect of centrally administered encephalinamides on regional cerebral blood flow in the dog.
Topics: Animals; Brain; Cerebrovascular Circulation; Cisterna Magna; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Injections; Male; Regional Blood Flow; Tissue Distribution | 1988 |
[Modulating effect of opioid peptides on hemopoiesis in stress].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hematopoiesis; Immobilization; Male; Mice; Stress, Psychological | 1988 |
[Bioavailability of dalargin and its metabolism during intranasal administration to rats].
Topics: Administration, Intranasal; Animals; Anti-Ulcer Agents; Biological Availability; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Rats, Inbred Strains | 1988 |
[Effect of a stable analog of leu-enkephalin, dalargin, on the cell division of the corneal epithelium in white rats].
Topics: Animals; Cell Division; Cornea; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mitotic Index; Rats | 1988 |
[Pharmacological correction of experimental alcoholic embryopathy].
Topics: Animals; Avoidance Learning; Conditioning, Classical; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Fetal Alcohol Spectrum Disorders; Motor Cortex; Photic Stimulation; Pregnancy; Rats; Succinate Dehydrogenase; Visual Cortex | 1988 |
[Effect of a synthetic analog of leu enkephalin on the status of higher mental functions in alcoholism].
Topics: Adult; Alcoholism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Higher Nervous Activity; Humans; Memory; Middle Aged; Neuropsychological Tests; Verbal Learning | 1987 |
Ethanol does not modify opiate-mediated inhibition of striatal adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Male; Mice; Mice, Inbred C57BL; Morphine | 1986 |
Leu-enkephalin impairs memory of an appetitive maze response in mice.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Learning; Male; Memory; Mice | 1986 |
Do opioid peptides modulate, at the level of the nerve endings, the release of neurohypophysial hormones?
Topics: Animals; Biomechanical Phenomena; Calcium; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dopamine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Naloxone; Nerve Endings; Oxytocin; Pituitary Gland, Posterior; Potassium; Rats; Rats, Inbred Strains; Stimulation, Chemical; Vasopressins | 1986 |
Bradykinin induces a rapid release of inositol trisphosphate from a neuroblastoma hybrid cell line NCB-20 that is not antagonized by enkephalin.
Topics: Animals; Bradykinin; Brain; Cell Line; Clone Cells; Cricetinae; Cricetulus; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Mice; Neuroblastoma; Neurons; Sugar Phosphates | 1986 |
Effect of endorphins on heart rate and blood pressure in adult dogs.
Topics: Animals; Atropine; Blood Pressure; Consciousness; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; Heart Rate; Naloxone; Naltrexone | 1986 |
Maturation of opioid sensitivity of fetal mouse dorsal root ganglion neuron perikarya in organotypic cultures: regulation by spinal cord.
Topics: Action Potentials; Animals; Calcium; Cell Count; Cell Separation; Cell Survival; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Mice; Mice, Inbred Strains; Nerve Crush; Neurons; Organ Specificity; Spinal Cord; Tetrodotoxin | 1986 |
Opioid mydriasis: cross-tolerance between morphine and enkephalins.
Topics: Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Pupil | 1986 |
Cerebrospinal fluid pharmacokinetics of intrathecal morphine sulfate and D-Ala2-D-Leu5-enkephalin.
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Infusions, Parenteral; Injections, Spinal; Kinetics; Morphine | 1986 |
[Role of endogenous opioid peptides in the regulation of pituitary secretions].
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gonadotropins, Pituitary; Humans; Pituitary Gland; Pituitary Hormones | 1986 |
Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carbachol; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Mice; Morphine; Norepinephrine; Organ Culture Techniques; Oxotremorine; Pertussis Toxin; Serotonin; Spinal Cord; Virulence Factors, Bordetella | 1987 |
Evidence for Des-Tyr1-D-Ala2-leucine5-enkephalinamide calcium agonist activity in vascular smooth muscle.
Topics: Animals; Calcium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitrendipine; Potassium Chloride; Rats; Reserpine; Serotonin; Verapamil | 1987 |
[Effect of the synthetic enkephalin dalargin on metabolic indices in myocardial infarct patients].
Topics: Adult; Aged; Blood Glucose; Calcium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Lactates; Magnesium; Male; Metabolism; Middle Aged; Myocardial Infarction; Triglycerides; Urea | 1987 |
[Immunomodulating action of neuropeptides in in vitro systems].
Topics: Adjuvants, Immunologic; Cell Migration Inhibition; Cells, Cultured; Coronary Disease; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Lymphocytes; Neuropeptides; Rosette Formation | 1987 |
[Effect of enkephalins on the adenine nucleotide concentrations of the liver and heart in experimental myocardial infarct].
Topics: Adenine Nucleotides; Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Liver; Male; Myocardial Infarction; Myocardium; Rats | 1987 |
Effects of (D-Ala2,D-Leu5)enkephalinamide on isolated longitudinal muscle guinea pig and rat intestines.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Intestines; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
[Effect of opioid receptor ligands on cell division processes in the corneal epithelium of the white rat].
Topics: Animals; Cell Division; Cornea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epithelium; Male; Naloxone; Rats | 1987 |
[2-(4-Chlorophenyl)sulfonylethoxycarbonyl (Cps) amino-protecting group for the synthesis of peptides in a solution. Synthesis of [Leu]enkephalin and its [D-ala2]analog].
Topics: Amino Acids; Carboxylic Acids; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Indicators and Reagents; Mass Spectrometry | 1987 |
[Effect of tageflar, a synthetic analog of L-enkephalin, on the morphogenesis of experimental pancreatitis].
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Pancreatitis; Rats | 1987 |
[Levels of hypophyseal-adrenal system hormones in the blood of acute myocardial infarct patients under treatment with the Soviet hexapeptide dalargin].
Topics: Adrenal Cortex Hormones; Adult; Aged; Drug Evaluation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Middle Aged; Myocardial Infarction; Pituitary Hormones | 1987 |
[Features of the action of opioid peptides and naloxone on the tissues of the central and peripheral nervous system during cultivation].
Topics: Animals; Culture Techniques; Drug Interactions; Embryo, Mammalian; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Naloxone; Organ Specificity; Rats; Rats, Inbred Strains; Spinal Cord | 1986 |
[Effect of enkephalins on the energy potential of the rat liver and cerebral cortex during an early period of traumatic shock].
Topics: Adenine Nucleotides; Animals; Cerebral Cortex; Energy Metabolism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Liver; Male; Rats; Shock, Traumatic; Time Factors | 1986 |
[Radioimmunologic and radioreceptor studies of the pharmacokinetics of the enkephalin analog dalargin in man].
Topics: Adult; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Male; Middle Aged; Radioimmunoassay; Radioligand Assay | 1986 |
[In vitro modulation using a synthetic antioxidant of the stimulus-induced formation of cyclic AMP].
Topics: Adenylyl Cyclases; Animals; Antioxidants; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Induction; Glucagon; In Vitro Techniques; Isoproterenol; Phenylpropionates; Rats | 1986 |
Synthesis, characterization, and structural properties of linear and cyclic enkephalin pseudopeptide diastereomers.
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Indicators and Reagents; Peptides, Cyclic; Stereoisomerism; Structure-Activity Relationship | 1986 |
Antiopioid activity of the cardioexcitatory peptide in central modulation of cardiovascular functions.
Topics: Animals; Blood Pressure; Cardiovascular System; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; FMRFamide; Heart Rate; Injections, Intraventricular; Male; Naloxone; Nerve Tissue Proteins; Rats; Shock, Hemorrhagic | 1986 |
[Effect of dalargin on systolic pressure in chronic experimental disorders of cardiovascular regulation].
Topics: Animals; Blood Pressure; Chronic Disease; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypertension, Renovascular; Male; Myocardial Contraction; Rats; Renal Artery Obstruction; Stress, Psychological; Systole | 1986 |
[Effect of dalargin on the glucocorticoid activity of the adrenals in stress].
Topics: Adrenal Glands; Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glucocorticoids; Rats; Stress, Physiological | 1986 |
[Effect of dalargin on the course of stress and shock in an experiment].
Topics: Animals; Crush Syndrome; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Shock, Traumatic; Stress, Psychological | 1986 |
[Dalargin--the most active synthetic analog of endogenous opioids for treating peptic ulcer (the results of a 5-year search)].
Topics: Animals; Anti-Ulcer Agents; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Peptic Ulcer | 1986 |
[Evaluation of the effectiveness of dalargin in treating exacerbated peptic ulcer under outpatient conditions at medical health units].
Topics: Adult; Ambulatory Care; Anti-Ulcer Agents; Drug Evaluation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Peptic Ulcer; Time Factors | 1986 |
[Effect of dalargin on the level of gastric secretion].
Topics: Animals; Anti-Ulcer Agents; Dogs; Drug Evaluation; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Acid; Humans; Peptic Ulcer | 1986 |
[Effect of the intravenous infusion of dalargin on biochemical and hormonal indices in the blood of patients with duodenal peptic ulcer].
Topics: Adult; Anti-Ulcer Agents; Drug Evaluation; Duodenal Ulcer; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hormones; Humans; Infusions, Intravenous; Male; Middle Aged | 1986 |
[Assessment of the endocrine status of peptic ulcer patients being treated with dalargin].
Topics: Anti-Ulcer Agents; Drug Evaluation; Duodenal Ulcer; Endocrine Glands; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Time Factors | 1986 |
[Effect of dalargin on pancreatic secretion].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Pancreas; Pancreatic Juice; Rats; Time Factors | 1986 |
[Effect of the peripheral administration of dalargin on ornithine decarboxylase activity in the duodenal mucosa of rats with experimental duodenal ulcers].
Topics: Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Duodenal Ulcer; Duodenum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraperitoneal; Intestinal Mucosa; Male; Ornithine Decarboxylase; Rats; Rats, Inbred Strains | 1986 |
[Dalargin--a regulator of reparative tissue regeneration].
Topics: Animals; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Rats, Inbred Strains; Regeneration; Swine; Swine, Miniature; Time Factors; Wound Healing | 1986 |
[Comparative study by a radioreceptor method of the pharmacokinetics of opiate ligands: morphine and dalargin].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Ligands; Morphine; Radioligand Assay; Time Factors | 1986 |
[Degradation of dalargin and its analogs in the brush border membranes of rat enterocytes studied by 1H-NMR spectroscopy].
Topics: Animals; Biotransformation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrolysis; Intestines; Magnetic Resonance Spectroscopy; Microvilli; Rats | 1986 |
[Effect of an opioid peptide on the healing of experimental myocardial infarct].
Topics: Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Microscopy, Electron; Myocardial Infarction; Myocardium; Necrosis; Rabbits; Time Factors; Wound Healing | 1986 |
[Effect of the hexapeptide dalargin on ornithine decarboxylase activity in the duodenal mucosa of rats in experimental duodenal ulcer].
Topics: Animals; Anti-Ulcer Agents; Cysteamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Duodenal Ulcer; Duodenum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Intestinal Mucosa; Male; Ornithine Decarboxylase; Rats; Rats, Inbred Strains | 1987 |
Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphine.
Topics: Adenocarcinoma; Bupivacaine; Clonidine; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Infusions, Parenteral; Injections, Intraventricular; Injections, Spinal; Middle Aged; Morphine; Nerve Block; Pain, Intractable; Pelvic Neoplasms; Terminal Care | 1985 |
Kainic acid and penicillin: differential effects on excitatory and inhibitory interactions in the CA1 region of the hippocampal slice.
Topics: Animals; Convulsants; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neural Inhibition; Penicillins; Pyrrolidines; Rats; Rats, Inbred Strains | 1985 |
Involvement of endogenous enkephalins in the feeding response to diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Eating; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Inbred Strains | 1985 |
Saturable [D-Ala2, D-Leu5]-enkephalin transport into cholinergic synaptic vesicles.
Topics: Acetylcholine; Animals; Biological Transport; Electric Organ; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Synaptic Vesicles; Temperature; Torpedo | 1985 |
Nasal delivery of polypeptides I: nasal absorption of enkephalins in rats.
Topics: Absorption; Administration, Intranasal; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Glycocholic Acid; Nasal Mucosa; Rats; Time Factors | 1985 |
Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine).
Topics: Animals; Blood-Brain Barrier; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Male; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Blockade of cholinergic receptors in the C1 area abolishes hypertensive response to opiates in the A1 area of the ventrolateral medulla.
Topics: Acetylcholine; Animals; Blood Pressure; Brain Mapping; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Reticular Formation; Vasomotor System | 1985 |
Comparative effects of opiate agonists on proximal and distal colonic motility in dogs.
Topics: Animals; Colon; Cyclazocine; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Injections, Intravenous; Injections, Spinal; Narcotics; Time Factors | 1985 |
Myoelectrical activity and propulsion in the large intestine of fed and fasted rats.
Topics: Action Potentials; Animals; Cathartics; Colon; Duodenum; Eating; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fasting; Gastrointestinal Motility; Male; Motor Activity; Muscle, Smooth; Narcotics; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Effect of opiates on the release of cholecystokinin from in vitro hypothalamus and frontal cortex of Zucker lean (Fa/-) and obese (fa/fa) rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Hypothalamus; Morphine; Naloxone; Obesity; Potassium; Rats; Rats, Zucker; Sincalide | 1985 |
A pharmacological characterization of chloride- and potassium-dependent inhibitions in the CA3 region of the rat hippocampus in vitro.
Topics: Animals; Baclofen; Chlorides; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hippocampus; In Vitro Techniques; Kainic Acid; Neural Inhibition; Neural Pathways; Norepinephrine; Potassium; Rats; Synapses | 1985 |
Locomotor activity of rats after injection of various opioids into the nucleus accumbens and the septum mediale.
Topics: Animals; Benzomorphans; Drug Synergism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections; Male; Morphine; Motor Activity; Naloxone; Narcotics; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Septum Pellucidum | 1985 |
[Effect of enkephalins on the course of experimental izadrin-induced myocardial necrosis in the rabbit].
Topics: Animals; Cardiomyopathies; Creatine Kinase; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Isoenzymes; Isoproterenol; L-Lactate Dehydrogenase; Male; Myoglobin; Necrosis; Propranolol | 1985 |
Hyperphagia induced by 2-deoxy-D-glucose in the presence of the delta-opioid antagonist ICI 174,864.
Topics: Animals; Deoxy Sugars; Deoxyglucose; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding and Eating Disorders; Hyperphagia; Male; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1985 |
Differential respiratory patterns induced by opioids applied to the ventral medullary and dorsal pontine surfaces of cats.
Topics: Animals; Carbon Dioxide; Cats; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Male; Medulla Oblongata; Morphine; Naloxone; Narcotics; Pons; Respiration; Tidal Volume; Time Factors | 1985 |
Molecular mechanisms of opiate tolerance and dependence in a clonal cell line.
Topics: Adenosine; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Naloxone; Narcotics; Nerve Tissue Proteins; Substance-Related Disorders | 1985 |
[Study of peptide degradation in the serum by 1H-NMR].
Topics: Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Oligopeptides | 1986 |
[Effect of enkephalins on the function of the calcium-regulating endocrine glands in shock].
Topics: Animals; Calcitonin; Calcium; Drug Evaluation, Preclinical; Endocrine Glands; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Parathyroid Hormone; Rats; Shock, Hemorrhagic; Shock, Traumatic; Time Factors | 1986 |
Central and peripheral control of gastrointestinal and colonic motility by endogenous opiates in conscious dogs.
Topics: Animals; Central Nervous System; Colon; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gastrointestinal Motility; Peripheral Nerves | 1985 |
[Enkephalins and the function of the sympathetic-adrenal system in acute myocardial ischemia].
Topics: Adrenal Glands; Animals; Catecholamines; Coronary Disease; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Sympathetic Nervous System; Time Factors | 1985 |
No inotropic action of enkephalins or enkephalin derivatives on electrically-stimulated atria isolated from lean and obese rats.
Topics: Animals; Atrial Function; Carbachol; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Norepinephrine; Obesity; Rats; Rats, Inbred Strains; Rats, Zucker; Stimulation, Chemical | 1985 |
[Effect of enkephalins on metabolic indices in experimental myocardial infarct in rats].
Topics: Animals; Blood Glucose; Calcium; Diuresis; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lactates; Liver Glycogen; Magnesium; Male; Myocardial Infarction; Rats | 1985 |
A novel phencyclidine analog interacts selectively with mu opioid receptors.
Topics: Analgesia; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Dihydromorphine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Naloxone; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, mu; Vas Deferens | 1984 |
Opioid-specific recognition sites of the mu- and the delta-type in rat striatum after lesions with kainic acid.
Topics: Animals; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kainic Acid; Kinetics; Male; Morphine Derivatives; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1984 |
Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: evidence for a two-site allosteric model.
Topics: Alkylating Agents; Allosteric Regulation; Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Isothiocyanates; Kinetics; Male; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates | 1984 |
Ionic conditions differentially affect 3H-DADL binding to type-I and type-II opiate delta receptors in vitro.
Topics: Animals; Brain; Calcium; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Isothiocyanates; Kinetics; Manganese; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Thiocyanates | 1984 |
[Binding sites of opiates and endogenous opioids in the oocytes of the toad Bufo viridis].
Topics: Animals; Benzomorphans; Binding Sites; Bufonidae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Kinetics; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Oocytes; Rabbits; Receptors, Opioid; Vas Deferens | 1984 |
Effects of ethanol, temperature, and endogenous regulatory factors on the characteristics of striatal opiate receptors.
Topics: Animals; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Guanosine Triphosphate; Male; Mice; Mice, Inbred C57BL; Receptors, Opioid; Sodium; Temperature | 1984 |
Effect of beta-FNA on opiate delta receptor binding.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Oligopeptides; Protein Conformation; Rats; Receptors, Opioid | 1984 |
Bidentate peptides: highly potent new inhibitors of enkephalin degrading enzymes.
Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Chromatography, Gel; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Hydroxamic Acids; Rabbits; Rats; Structure-Activity Relationship | 1984 |
Neuronal sensitivity to opiate and opioid peptides in the bed nucleus of the stria terminalis. Effects of chronic treatment with morphine.
Topics: Amygdala; Animals; Dihydromorphine; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Evoked Potentials; Guinea Pigs; Hypothalamus, Middle; Male; Morphine; Neural Pathways; Neurons; Norepinephrine; Receptors, Opioid; Synaptic Transmission | 1984 |
[Stability of opiate receptors of wet and lyophilized preparations of rat brain membranes].
Topics: Animals; Binding Sites; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Freeze Drying; In Vitro Techniques; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds.
Topics: Animals; Antidepressive Agents; Binding, Competitive; Cerebellum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Kinetics; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Opioid control of the ruminant stomach motility: functional importance of mu, kappa and delta receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep; Stomach | 1984 |
Sodium regulation of opioid agonist binding is potentiated by pertussis toxin.
Topics: Animals; Bacterial Toxins; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanine Nucleotides; Hybrid Cells; Mice; Morphinans; Neuroblastoma; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Virulence Factors, Bordetella | 1984 |
Inhibition of the cardiac response to sympathetic nerve stimulation by opioid peptides and its potentiation by morphine and methadone.
Topics: Animals; beta-Endorphin; Drug Synergism; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Guinea Pigs; Heart; In Vitro Techniques; Male; Methadone; Morphine; Myocardial Contraction; Norepinephrine; Sympathetic Nervous System | 1984 |
[3H]Ethylketocyclazocine binding to mouse brain membranes: evidence for a kappa opioid receptor type.
Topics: Animals; Brain; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1984 |
Effects of delta and mu opiopeptides on the turnover and release of dopamine in rat striatum.
Topics: Animals; Corpus Striatum; Dopamine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1984 |
Up-regulation of opiate receptors by opiate antagonists in neuroblastoma-glioma cell culture: the possibility of interaction with guanosine triphosphate-binding proteins.
Topics: Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Autoradiographic localization of opioid receptors in the rat stomach.
Topics: Animals; Autoradiography; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Myenteric Plexus; Rats; Rats, Inbred Strains; Receptors, Opioid; Submucous Plexus | 1984 |
Altered opiate receptor binding in synaptosomes: implication of phosphorylation.
Topics: Animals; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Phosphorylation; Receptors, Opioid; Synaptosomes | 1984 |
Mu and delta opioid receptor interactions in a rat model of drug induced seizures.
Topics: Animals; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1984 |
[The effect of di- and trivalent metal ions on the binding of [3H-Tyr1, D-Ala2, D-Leu5] enkephalin to opiate receptors from the rat brain].
Topics: Animals; Binding Sites; Brain; Cations; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Kinetics; Male; Membranes; Metals; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin.
Topics: Animals; Body Temperature; Body Temperature Regulation; Cats; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
[Effect of di- and trivalent metal ions on the complexing of D-ala2, D-leu5-enkephalin with opiate receptors of brain membrane preparations].
Topics: Animals; Binding Sites; Chelating Agents; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Ions; Male; Meninges; Metals; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Opioid receptor subtypes involved in the central inhibition of urinary bladder motility.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Morphine; Muscle Contraction; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1984 |
Involvement of endogenous opioid systems in social behavior of individually-housed mice.
Topics: Aggression; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Methadone; Mice; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Receptors, Opioid; Social Behavior; Social Isolation | 1984 |
Identification of an opioid receptor subunit carrying the mu binding site.
Topics: Affinity Labels; Alkylation; Amino Acid Chloromethyl Ketones; Animals; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; Intracellular Membranes; Microsomes; Mitochondria; Molecular Weight; Rats; Receptors, Opioid; Synaptic Membranes | 1984 |
Effect of electroconvulsive treatment on cerebral opioid receptors in the rat: changes in delta but not mu receptors.
Topics: Animals; Brain; Corpus Striatum; Electroshock; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Membranes; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1984 |
Evidence for the presynaptic localization of opiate binding sites on striatal efferent fibers.
Topics: Animals; Autoradiography; Corpus Striatum; Efferent Pathways; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Globus Pallidus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Substantia Nigra; Synaptic Membranes | 1984 |
Opposite effects of the delta- and mu-opioid receptor agonists on ventilation in conscious adult dogs.
Topics: Animals; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Respiratory Center | 1984 |
Two new opioid delta-receptor ligands: a highly selective agonist and a potent selective antagonist in in vitro isolated preparations.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Ligands; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1984 |
Inhibition via opioid mu- and delta-receptors of vagal transmission in rabbit isolated heart.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; In Vitro Techniques; Male; Morphine; Naloxone; Parasympathetic Nervous System; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptic Transmission; Vagus Nerve | 1984 |
[Biochemical aspects of enkephalin participation in the regulation of adrenergic effects on myocardium].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Creatine Kinase; Cyclic AMP; Cyclic GMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; Isoenzymes; Isoproterenol; Magnesium; Male; Myocardium; Rabbits; Rats | 1984 |
Application of receptor theory provides further evidence for the existence of the epsilon-opioid receptor in rat vas deferens.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens | 1984 |
Kappa 3: a novel subtype of the kappa opioid site in bovine adrenal medulla, highly selective for Met-enkephalin-Arg6-Phe7.
Topics: Adrenal Medulla; Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; In Vitro Techniques; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Gpp(NH)p promotes the formation of a low affinity state for the delta opioid agonist-receptor complex.
Topics: Animals; Cattle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; In Vitro Techniques; Kinetics; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes | 1984 |
Electroencephalographic assessment of the role of delta receptors in opioid peptide - induced seizures.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures | 1984 |
Tolerance and withdrawal are associated with ligand dependent receptor regulation in vitro and in vivo.
Topics: Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Hybrid Cells; Morphine; Morphine Dependence; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1984 |
The effects of kappa opioid agonists in the rat hippocampal slice.
Topics: Animals; Benzodiazepines; Benzomorphans; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hippocampus; In Vitro Techniques; Male; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Inhibition of oxytocin secretion by mu and delta receptor selective enkephalin analogues.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Lactation; Oxytocin; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1984 |
Mechanisms of opioid tolerance and dependence.
Topics: Animals; Drug Tolerance; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Humans; Hybrid Cells; Ileum; In Vitro Techniques; Male; Mice; Naloxone; Neurons; Receptors, Opioid; Substance-Related Disorders; Vas Deferens | 1984 |
Opiate binding in the rat spinal cord: evidence for mu and delta sites.
Topics: Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1984 |
Influence of intracerebroventricular (ICV) GTP-electrolyte infusion on ICV (D-ALA2, D-LEU5) enkephalin (DADL)-induced cardiovascular effects in rats.
Topics: Animals; Blood Pressure; Chlorides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Heart Rate; Injections, Intraventricular; Male; Manganese; Manganese Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride | 1984 |
Mechanisms of multiple cellular adaptation processes in clonal cell lines during chronic opiate treatment.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanylyl Imidodiphosphate; Lanthanum; Mice; Naloxone; Narcotics; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Time Factors | 1984 |
Stimulation of dopamine synthesis and release by morphine and D-ala2-D-leu5-enkephalin in the mouse striatum in vivo.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benztropine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; Tyrosine 3-Monooxygenase | 1981 |
Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; Guanosine Triphosphate; Phosphoric Monoester Hydrolases; Rats; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 1981 |
Distinct high-affinity binding sites for benzomorphan drugs and enkephalin in a neuroblastoma--brain hybrid cell line.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cell Line; Cyclazocine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hybrid Cells; Kinetics; Morphinans; Neuroblastoma; Phenazocine; Rats; Receptors, Opioid | 1981 |
The preference of putative pro-enkephalins for different types of opiate receptors.
Topics: Animals; Benzomorphans; Brain; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Morphine; Protein Precursors; Rats; Receptors, Opioid; Vas Deferens | 1981 |
Mu and delta opiate receptors in rat brain are affected by GTP but not by MIF-1.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanosine Triphosphate; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium; Temperature | 1981 |
Stereospecific inhibition of oxotremorine-induced antinociception by (+)-isomers of opioid antagonists: comparison with opioid receptor agonists.
Topics: Animals; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Mice; Morphine; Narcotic Antagonists; Nociceptors; Oxotremorine; Receptors, Opioid; Stereoisomerism | 1982 |
In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Injections, Spinal; Male; Naloxone; Pain; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1982 |
Kappa opiate receptors localized by autoradiography to deep layers of cerebral cortex: relation to sedative effects.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Benzomorphans; Brain Stem; Cerebral Cortex; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Morphine; Organ Specificity; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1982 |
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Intrathecal delta-receptor ligand produces analgesia in man.
Topics: Aged; Analgesia; Animals; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Injections, Spinal; Male; Morphine; Pain, Intractable; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Inhibition of an opioid-evoked vagal reflex in rats by naloxone, SMS 201-995 and ICI 154, 129.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Kinetics; Male; Morphine; Naloxone; Octreotide; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Somatostatin; Vagus Nerve | 1983 |
Responses of substantia gelatinosa neurons to putative neurotransmitters in an in vitro preparation of the adult rat spinal cord.
Topics: Animals; Culture Techniques; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; gamma-Aminobutyric Acid; Ganglia, Spinal; Glutamates; Glutamic Acid; Male; Neurons; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Spinal Cord; Substantia Gelatinosa; Synaptic Transmission | 1983 |
Comparison of analgesic potencies of mu, delta and kappa agonists locally applied to various CNS regions relevant to analgesia in rats.
Topics: Analgesics, Opioid; Animals; Brain Stem; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
[Mechanism of the hypotensive effect of parathyroid hormone].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Cyclic AMP; Depression, Chemical; Droperidol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Muscle, Smooth, Vascular; Parathyroid Hormone; Rats; Verapamil | 1984 |
Solubilization in high yield of opioid receptors retaining high-affinity delta, mu and kappa binding sites.
Topics: Animals; Binding Sites; Brain Chemistry; Cell Membrane; Chemical Precipitation; Detergents; Digitonin; Drug Stability; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Magnesium; Peptide Fragments; Polyethylene Glycols; Rats; Receptors, Opioid; Solubility | 1984 |
Opioid receptor sub-types involved in the control of transmitter release in cortex of the brain of the rat.
Topics: Animals; beta-Lipotropin; Cerebral Cortex; Clomipramine; Edetic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estradiol; In Vitro Techniques; Male; Morphine; Morphine Derivatives; Naloxone; Narcotics; Neurotransmitter Agents; Norepinephrine; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin | 1984 |
Gangliosides as modulators of the coupling of neurotransmitters to adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Line; Clonidine; Cricetinae; Cricetulus; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gangliosides; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Neurons; Neurotransmitter Agents; Receptors, Serotonin | 1984 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Opiates stimulate low Km GTPase in brain.
Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; GTP Phosphohydrolases; Guanosine Triphosphate; Male; Naloxone; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Benzomorphan sites are ligand recognition sites of putative epsilon-receptors.
Topics: Animals; Benzomorphans; beta-Endorphin; Binding, Competitive; Brain; Cell Membrane; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Guinea Pigs; Humans; Kinetics; Morphinans; Peptide Fragments; Placenta; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Effects of opiate and alpha 2-adrenergic agonists in a neuroblastoma x brain explant hybrid cell line (NCB-20).
Topics: Adrenergic alpha-Agonists; Alprostadil; Animals; Brain; Cell Line; Clonidine; Cricetinae; Cricetulus; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Mice; Narcotics; Neuroblastoma; Neurons; Prostaglandins E | 1984 |
Behavioural and biochemical effects in C57BL/6J mice after a prolonged treatment with the delta-opiate antagonist ICI 154129.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain Chemistry; Brain Stem; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Levorphanol; Male; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Characteristics of 3H-tifluadom binding in guinea-pig brain membranes.
Topics: Animals; Benzodiazepines; Benzomorphans; Binding Sites; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Morphine; Receptors, Opioid | 1984 |
Studies on the pharmacology of central opioid-induced increases in plasma catecholamines in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Analgesics; Animals; Catecholamines; Dioxanes; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; Injections, Intraventricular; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1984 |
Effects of dynorphin A (1-17), dynorphin A (1-13) and D-ala2-D-leu5-enkephalin on the excitability of pyramidal cells in CA1 and CA2 of the rat hippocampus in vitro.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Hippocampus; In Vitro Techniques; Peptide Fragments; Rats; Receptors, Opioid | 1984 |
Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1-17) on neocortical neurons in vitro.
Topics: Animals; Cerebral Cortex; Dynorphins; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Neurons; Peptide Fragments; Rats; Rats, Inbred Strains | 1984 |
[Inhibitory effects of dynorphin on electric field stimulation induced contraction of blood vessels in vitro].
Topics: Animals; Dogs; Dynorphins; Ear; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; In Vitro Techniques; Mesenteric Arteries; Naloxone; Rabbits; Receptors, Opioid; Vasoconstriction | 1984 |
Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum.
Topics: Acetylcholinesterase; Animals; Axonal Transport; Caudate Nucleus; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Leucine; Naloxone; Proline; Rats; Receptors, Opioid | 1981 |
Differential effects of D-Ala2 analogues of enkephalins on substance P-induced analgesia in rodents.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Rats; Rats, Inbred Strains; Substance P | 1982 |
Opioid-mediated acute responses to alcohol: ethanol potentiates opioid actions on the guinea pig ileum.
Topics: Acetylcholine; Animals; Drug Interactions; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Substance P | 1983 |
Studies on the opiate receptor-mediated inhibition of K+-stimulated cholecystokinin and substance P release from cat hypothalamus in vitro.
Topics: Animals; Cats; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamus; Morphine; Naloxone; Potassium; Receptors, Opioid; Substance P | 1984 |
Analgesic activity of substance P in rats: tolerance and cross-tolerance with enkephalin.
Topics: Analgesics; Animals; Drug Tolerance; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Substance P | 1984 |
Tritiated-6-beta-fluoro-6-desoxy-oxymorphone: a highly selective ligand for the opiate mu receptor whose binding is characterized by low nonspecific binding.
Topics: Animals; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Hydromorphone; Isothiocyanates; Kinetics; Oxymorphone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Tomography, Emission-Computed | 1984 |
Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electric Stimulation; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Humans; Male; Mice; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Substance-Related Disorders; Sufentanil; Vas Deferens | 1980 |
Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites.
Topics: Adrenal Medulla; Animals; Brain; Cattle; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Organ Specificity; Rabbits; Rats; Receptors, Opioid; Species Specificity; Vas Deferens | 1980 |
A selective distribution pattern of different opiate receptors in certain areas of rat brain as revealed by in vitro autoradiography.
Topics: Animals; Autoradiography; Brain; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Male; Rats; Receptors, Opioid | 1981 |
Mature spinal ganglion cells are not sensitive to opiate receptor mediated actions.
Topics: Action Potentials; Aminopyridines; Animals; Barium; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Ganglia, Spinal; Iontophoresis; Morphine; Morphine Derivatives; Naloxone; Narcotics; Rats; Receptors, Opioid | 1981 |
The distribution of multiple opiate receptors in bovine brain.
Topics: Animals; Brain; Cattle; Enkephalin, Leucine-2-Alanine; Enkephalins; Morphine; Receptors, Opioid | 1981 |
Involvement of mu-receptors in the opioid-induced generation of bursting discharges in hippocampal pyramidal cells.
Topics: Animals; Benzomorphans; Culture Techniques; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Electrophysiology; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Membrane Potentials; Morphinans; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1981 |
Naloxazone irreversibly inhibits the high affinity binding of [125I]D-ala2-D-leu5-enkephalin.
Topics: Animals; Binding, Competitive; Brain; Cells, Cultured; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Kinetics; Membranes; Morphine; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid | 1981 |
Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.
Topics: Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Naloxone; Naltrexone; Narcotics; Phenoxybenzamine; Receptors, Opioid | 1981 |
Opiate effects on rabbit vagus nerve: electrophysiology and radioligand binding.
Topics: Action Potentials; Animals; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Evoked Potentials; Kinetics; Morphine; Morphine Derivatives; Nodose Ganglion; Rabbits; Receptors, Opioid; Structure-Activity Relationship; Vagus Nerve | 1981 |
Effect of lithium and sodium ions on opiate- and dopamine-receptor binding.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Lithium; Naloxone; Rats; Receptors, Dopamine; Receptors, Opioid; Sodium; Spiperone | 1981 |
Opiate receptor heterogeneity in human brain regions.
Topics: Binding, Competitive; Brain; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Kinetics; Naloxone; Organ Specificity; Receptors, Opioid | 1981 |
Binding and metabolism studies with [3H](D-Ala2,Leu5)enkephalinamide and [3H](D-Ala2,Pro5)enkephalinamide: evidence for a selective interaction of (D-Ala2,Pro5)enkephalinamide with mu-receptors.
Topics: Animals; Binding, Competitive; Brain; Endopeptidases; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ileum; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Narcotics; Neprilysin; Peptide Hydrolases; Receptors, Opioid; Receptors, Opioid, mu | 1981 |
Strain differences in opiate receptors in mouse brain.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naloxone; Receptors, Opioid; Species Specificity | 1981 |
Comparison of analgesic and body temperature responses to intrathecal beta-endorphin and D-Ala2-D-Leu5-enkephalin.
Topics: Analgesics; Animals; beta-Endorphin; Body Temperature; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Spinal; Male; Rats; Rats, Inbred Strains; Reaction Time; Time Factors | 1981 |
Both mu and delta opiate receptors exist on the same neuron.
Topics: Animals; Dihydromorphine; Electric Conductivity; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Morphine Derivatives; Myenteric Plexus; Neurons; Receptors, Opioid | 1981 |
Ontogeny of opiate receptors in rat forebrain: visualization by in vitro autoradiography.
Topics: Aging; Animals; Autoradiography; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Naloxone; Neurons; Olfactory Pathways; Pregnancy; Rats; Receptors, Opioid; Septum Pellucidum; Telencephalon | 1981 |
Dehydro-enkephalins: receptor binding activity of unsaturated analogs of Leu5-enkephalin.
Topics: Animals; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Further characterization of opioid receptors in the striatum mediating muscular rigidity in rats.
Topics: Animals; beta-Endorphin; Caseins; Caudate Nucleus; Electromyography; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Haloperidol; Male; Morphine; Muscle Rigidity; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Mixed type inhibition of [D-Ala2, D-Leu5]enkephalin binding to mu-opiate binding sites by mu-, but not by kappa-opiate ligands.
Topics: Animals; Binding, Competitive; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Ligands; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1982 |
D-Ala2,D-Leu5-enkephalin generalizes to a discriminative stimulus produced by fentanyl but not ethylketocyclazocine.
Topics: Animals; Cyclazocine; Discrimination, Psychological; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Fentanyl; Generalization, Stimulus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Differential postnatal development of mu and delta opiate receptors.
Topics: Aging; Animals; Brain; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1982 |
Pulmonary opiate receptor activation evokes a cardiorespiratory reflex.
Topics: Animals; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hemodynamics; Lung; Male; Myocardial Contraction; Peripheral Nerves; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Respiration; Time Factors | 1982 |
Analgesic activity of intracerebroventricular administration of morphiceptin and beta-casomorphins: correlation with the morphine (micro) receptor binding affinity.
Topics: Analgesia; Animals; Binding, Competitive; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Rats; Receptors, Opioid | 1982 |
Physiological correlates of multiple subtypes of enteric opiate receptor; functional analysis of myenteric delta receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Morphine; Morphine Derivatives; Myenteric Plexus; Receptors, Opioid; Receptors, Opioid, delta | 1982 |
Opioids increase laryngeal resistance and motoneuron activity in the recurrent laryngeal nerve.
Topics: Animals; Biguanides; Chemoreceptor Cells; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Laryngeal Nerves; Larynx; Male; Morphine; Motor Neurons; Rats; Receptors, Opioid; Recurrent Laryngeal Nerve; Reflex | 1982 |
Dehydro-enkephalins. III. Synthesis and biological activity of [delta Ala2, Leu5]-enkephalin.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Methods; Rats; Receptors, Opioid | 1982 |
Naltrexone-induced opiate receptor supersensitivity.
Topics: Animals; Brain; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Female; Guanosine Triphosphate; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Opiate and opioid peptide binding in rat goldfish: further evidence for opiate receptor heterogeneity.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Goldfish; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1982 |
Demonstration of a slowly dissociating form of bovine hippocampal synaptic membrane opiate receptors.
Topics: Animals; Cattle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hippocampus; In Vitro Techniques; Kinetics; Receptors, Opioid; Synaptic Membranes; Thermodynamics | 1982 |
Enkephalin inhibition of inhibitory input to CA1 and CA3 pyramidal neurons in the hippocampus.
Topics: Animals; Bicuculline; Culture Techniques; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Interneurons; Membrane Potentials; Neural Inhibition; Neurons; Reaction Time; Synapses; Synaptic Transmission | 1982 |
Opiate receptor-mediated inhibition of catecholamine release in primary cultures of bovine adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; beta-Endorphin; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Phenazocine; Receptors, Opioid | 1982 |
Dimeric pentapeptide enkephalin: a novel probe of delta opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Manganese; Naloxone; Radioligand Assay; Rats; Receptors, Opioid; Sodium | 1982 |
Inhibition of tail-flick and shaking responses by intrathecal and intraventricular D-Ala2-D-Leu5-enkephalin and beta-endorphin in anesthetized rats.
Topics: Analgesics; Anesthesia; Animals; Behavior, Animal; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Spinal; Male; Pentobarbital; Rats; Rats, Inbred Strains | 1983 |
Delta versus mu receptors: cardiovascular and respiratory effects of opiate agonists microinjected into nucleus tractus solitarius of cats.
Topics: Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Heart Rate; Injections, Intraventricular; Microinjections; Naloxone; Receptors, Opioid; Respiration | 1982 |
Autoradiographic localization of opiate kappa-receptors in the guinea-pig brain.
Topics: Animals; Autoradiography; Benzomorphans; Binding, Competitive; Brain; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Hypothalamus, Middle; Male; Receptors, Opioid; Receptors, Opioid, kappa | 1982 |
Characterization of the association of tritiated enkephalin with neuroblastoma cells under conditions optimal for receptor down regulation.
Topics: 2,4-Dinitrophenol; Animals; Cell Line; Dinitrophenols; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Mice; Neuroblastoma; Receptors, Opioid; Temperature | 1983 |
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid | 1983 |
Evidence for multiple "Kappa" binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord.
Topics: Animals; Binding Sites; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1982 |
Interaction of naloxone with mu- and delta-opioid agonists on the respiration of rats.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotics; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Time Factors | 1983 |
Partial cross tolerance to D-Ala2-D-Leu5-enkephalin after chronic spinal morphine infusion.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hot Temperature; Kinetics; Male; Morphine; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Spinal Cord | 1983 |
Cardiovascular and respiratory effects of mu-, delta- and kappa-opiate agonists microinjected into the anterior hypothalamic brain area of awake rats.
Topics: Animals; Anterior Hypothalamic Nucleus; Benzomorphans; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Male; Microinjections; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Wakefulness | 1983 |
Multiple opiate binding sites in the central nervous system of the rabbit. Large predominance of a mu subtype in the cerebellum and characterization of a kappa subtype in the thalamus.
Topics: Animals; Binding, Competitive; Central Nervous System; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Membranes; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thalamus | 1983 |
Multiple opiate receptors in the mouse vas deferens.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Mice; Morphine Derivatives; Muscle, Smooth; Receptors, Opioid; Temperature; Vas Deferens | 1983 |
Multiple opiate receptor affinities of kappa and agonist/antagonist analgesics: in vivo assessment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesia; Animals; Buprenorphine; Butorphanol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism; Substrate Specificity | 1983 |
Photolabile opioid derivatives of D-Ala2-Leu5-enkephalin and their interactions with the opiate receptor.
Topics: Animals; Biological Assay; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Muscle Contraction; Photolysis; Rats; Receptors, Opioid; Vas Deferens | 1983 |
Functional opiate receptor in mouse vas deferens: evidence for a complex interaction.
Topics: Animals; Arylsulfatases; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Sulfatases; Vas Deferens | 1983 |
The binding to rat brain homogenates of Mr2034, a universal opiate.
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphinans; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isomerism; Kinetics; Muscle Contraction; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1983 |
Dynorphin-(1-13): the effect of in vivo treatment on opiate bindings in vitro.
Topics: Animals; Brain; Dihydromorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Peptide Fragments; Receptors, Opioid | 1983 |
Further evidence for an opioid receptor complex.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; In Vitro Techniques; Rats; Receptors, Opioid | 1983 |
Cell cycle-dependent expression of specific opiate binding with variable coupling to adenylate cyclase in a neurotumor hybrid cell line NG108-15.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Cell Cycle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanylyl Imidodiphosphate; Hybrid Cells; Mice; Neoplasms, Nerve Tissue; Prostaglandins E; Rats; Receptors, Opioid | 1983 |
Glycosylation-dependent regulation of opiate (enkephalin) receptors in neurotumor cells.
Topics: Animals; Carbohydrate Metabolism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hybrid Cells; Mice; Neoplasms, Nerve Tissue; Rats; Receptors, Opioid; Tunicamycin | 1983 |
The spinal cord as a site of opioid effects on gastrointestinal transit in the mouse.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Stimulation, Chemical | 1983 |
Opiate binding sites in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Binding Sites; Brain; Brain Chemistry; Cattle; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Ligands; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Chronic ethanol alters the receptor binding characteristics of the delta opioid receptor ligand, D-Ala2-D-Leu5 enkephalin in mouse brain.
Topics: Alcoholism; Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Humans; Male; Mice; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1983 |
Evaluation of the interactions of mu and delta selective ligands with [3H]D-Ala2-D-Leu5-enkephalin binding to mouse brain membranes.
Topics: Animals; Binding, Competitive; Brain; Computers; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Ligands; Male; Membranes; Mice; Models, Biological; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1983 |
Inhibition of the antisecretory effects of [D-Ala2,D-Leu5]enkephalin in the guinea-pig ileum by a selective delta opioid antagonist.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Membrane Potentials; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Modulation of acid secretion from enriched guinea pig parietal cells by opioid receptors.
Topics: Animals; Binding Sites; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Acid; Guinea Pigs; In Vitro Techniques; Male; Naloxone; Parietal Cells, Gastric; Receptors, Opioid; Tritium | 1983 |
Computer-assisted analysis of receptor-binding studies of [3H]-naloxone and [3H]-DADL: a reinterpretation of the Na+ effect.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Naloxone; Rats; Receptors, Opioid; Sodium | 1983 |
Effect of human B-endorphin on the binding of different opiates to mouse brain membranes.
Topics: Animals; beta-Endorphin; Brain; Cell Membrane; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Mice; Receptors, Opioid | 1983 |
Unmasking myenteric delta receptors.
Topics: Animals; Biological Assay; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ileum; Morphine; Muscle Contraction; Myenteric Plexus; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Detailed receptor binding studies of a series of N-substituted ethyl 3-arylnipecotates.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Naloxone; Nipecotic Acids; Rats; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1983 |
A new potential affinity label for the opiate receptor.
Topics: Affinity Labels; Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Melphalan; Rats; Receptors, Opioid | 1983 |
A selective role for delta-receptors in the regulation of opioid-induced changes in seizure threshold.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Meperidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures; Sensory Thresholds | 1983 |
Comparison of mu, delta, and kappa opiate binding sites in rat brain and spinal cord.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1984 |
Opiate binding to subcellular fractions from guinea pig ileum.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Guinea Pigs; Ileum; In Vitro Techniques; Receptors, Opioid; Subcellular Fractions | 1984 |
Effect of digitonin on the binding of opiate agonists and antagonists to membrane-bound and soluble opioid binding sites.
Topics: Animals; Brain; Bufo marinus; Digitonin; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Species Specificity | 1984 |
Chronic ethanol changes opiate receptor function in rat striatum.
Topics: Animals; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethanol; Etorphine; Male; Rats; Receptors, Opioid | 1984 |
ICI 154,129, a delta-opioid receptor antagonist raises seizure threshold in rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Visualization of enkephalin receptors by image-intensified fluorescence microscopy.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Iodine Radioisotopes; Mice; Microscopy, Fluorescence; Neuroblastoma; Receptors, Opioid; Xanthenes | 1983 |
The regulation of delta-opiate receptor density on 108CC15 neuroblastoma X glioma hybrid cells.
Topics: Animals; Bucladesine; Cell Differentiation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Hybrid Cells; Mice; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Down-regulation of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Chloroquine promotes accumulation of tritiated enkephalin in the lysosomes.
Topics: Animals; Cell Line; Chloroquine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Kinetics; Lysosomes; Mice; Neuroblastoma; Rats; Receptors, Opioid | 1984 |
Biochemical characterization of high-affinity 3H-opioid binding. Further evidence for Mu1 sites.
Topics: Animals; Brain; Cell Membrane; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Kinetics; Male; Morphine; Morphine Derivatives; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tritium; Trypsin | 1984 |
Down regulation of opiate receptors on 108CC15 hybrid cells is inhibited by receptor occupancy.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Light microscopic autoradiographic localization of mu and delta opioid binding sites in the mouse central nervous system.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Mice; Mice, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tissue Distribution; Tritium | 1984 |
Selective cardiorespiratory effects mediated by mu opioid receptors in the nucleus ambiguus.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Male; Medulla Oblongata; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Respiration, Artificial | 1984 |
Microelectrophoretic administration of naloxone near motoneurones fails to reproduce the effects of systemic naloxone in anaesthetized cats.
Topics: Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Hindlimb; Membrane Potentials; Motor Neurons; Muscles; Naloxone; Neural Inhibition; Reflex, Stretch; Spinal Cord; Synaptic Transmission | 1984 |
Comparison of the effectiveness of different opioid peptides in suppressing heroin withdrawal.
Topics: Adult; Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heroin; Humans; Male; Mice; Peptide Fragments; Protein Precursors; Substance Withdrawal Syndrome | 1984 |
A photoaffinity reagent to label the opiate receptors of guinea pig ileum and mouse vas deferens.
Topics: Affinity Labels; Animals; Azides; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Photochemistry; Receptors, Opioid; Vas Deferens | 1984 |
Opioid antagonism of electroshock-induced seizures.
Topics: Animals; beta-Endorphin; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Seizures; Time Factors | 1984 |
A very high affinity opioid binding site in rat brain: demonstration by computer modeling.
Topics: Animals; Binding, Competitive; Brain Chemistry; Computers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Mathematics; Models, Chemical; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Characterization and down-regulation of opiate receptors in aggregating fetal rat brain cells.
Topics: Animals; Brain; Cell Aggregation; Cells, Cultured; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Fetus; Molecular Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
[3H]ethylketocyclazocine binding to NCB-20 hybrid neurotumor cells.
Topics: Animals; Binding, Competitive; Brain; Cricetinae; Cricetulus; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Hybrid Cells; Kinetics; Neuroblastoma; Trypsin | 1983 |
Studies on the transport of enkephalin-like oligopeptides in rat intestinal mucosa.
Topics: Aminopeptidases; Animals; Biological Transport, Active; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Intestinal Mucosa; Jejunum; Kinetics; Leucine; Male; Oligopeptides; Puromycin; Rats; Rats, Inbred Strains; Tyrosine | 1983 |
Long-term ethanol alters the binding of 3H-opiates to brain membranes.
Topics: Animals; Brain; Cell Membrane; Dihydromorphine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Male; Morphine Derivatives; Naloxone; Rats; Rats, Inbred Strains | 1983 |
Correlation between the distribution of 3H-labelled enkephalin in rat brain and the anatomical regions involved in enkephalin-induced seizures.
Topics: Animals; Autoradiography; Brain; Diffusion; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Seizures | 1983 |
Effects of morphine and D-Ala, D-Leu enkephalin on the electrical activity of supraoptic neurosecretory cells in vitro.
Topics: Animals; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Neurons; Neurosecretory Systems; Rats; Supraoptic Nucleus | 1983 |
Plasma catecholamine and cardiovascular responses to morphine and D-ala2-d-leu5-enkephalin in conscious rats.
Topics: Adrenalectomy; Animals; Blood Pressure; Catecholamines; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Male; Morphine; Rats; Rats, Inbred Strains; Respiration | 1983 |
Properties of murine anti-morphine antibodies.
Topics: Animals; Antibodies, Monoclonal; Chromatography, Affinity; Cross Reactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Immunoglobulin G; Mice; Mice, Inbred BALB C; Morphine; Narcotic Antagonists | 1983 |
Participation of pontine structures in the respiratory action of opioids.
Topics: Animals; Blood Pressure; Cats; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Hormones; Morphine; Pons; Respiration; Vagotomy | 1983 |
The effects of D-ala2, D-Leu5-enkephalin injections into the nucleus accumbens on the motility of rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei | 1983 |
Comparison of the filtration and centrifugation methods for assaying [3H](D-ala2, D-leu5)enkephalin binding to mouse brain membranes.
Topics: Animals; Brain; Cell Membrane; Centrifugation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Filtration; Male; Mice; Morphine; Time Factors | 1983 |
Synthesis and biological activity of (D)Ala2,Leu5-enkephalins containing hydrophilic or hydrophobic moieties.
Topics: Analgesia; Animals; Biological Assay; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Muscle Contraction; Structure-Activity Relationship | 1983 |
[Interaction of the enkephalin- and dopamine-containing systems of the caudate nucleus head in realizing a conditioned food reflex in dogs].
Topics: Acoustic Stimulation; Animals; Caudate Nucleus; Conditioning, Classical; Dogs; Dopamine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Feeding Behavior; Haloperidol; Male; Time Factors | 1984 |
Effect of enkephalin and naloxone on vagal and hormonal stimulation of pancreatic secretion in man.
Topics: Adult; Bicarbonates; Enkephalin, Leucine-2-Alanine; Enkephalins; Food; Gastric Acid; Gastrins; Humans; Male; Naloxone; Pancreas; Proteins; Secretin | 1983 |
Effect of intrahypothalamic injection of [D-Ala2,D-Leu5]enkephalin on feeding and temperature in the rat.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Hypothalamus; Injections, Intraventricular; Male; Morphine; Naloxone; Phentolamine; Rats; Rats, Inbred Strains | 1983 |
A comparative study in rats of the respiratory depression and analgesia induced by mu- and delta-opioid agonists.
Topics: Analgesia; Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Male; Morphine; Oligopeptides; Rats; Rats, Inbred Strains; Respiration | 1984 |
Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats.
Topics: Analgesics; Animals; Benzomorphans; Catatonia; Constipation; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Gastrointestinal Motility; Humans; Male; Morphinans; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
The metabolism of neuropeptides. Both phosphoramidon-sensitive and captopril-sensitive metallopeptidases are present in the electric organ of Torpedo marmorata.
Topics: Animals; Captopril; Cell Membrane; Electric Organ; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glycopeptides; Hydrolysis; In Vitro Techniques; Metalloendopeptidases; Nerve Tissue Proteins; Oligopeptides; Phenanthrolines; Torpedo | 1984 |
Disappearance of enkephalins in the isolated perfused rat lung.
Topics: Angiotensin I; Angiotensin II; Animals; Biological Assay; Captopril; Colon; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Indomethacin; Lung; Perfusion; Prostaglandins; Rats; Rats, Inbred Strains; Stomach | 1984 |
Drinking behavior is modulated by CNS administration of opioids in the rat.
Topics: Animals; Brain; Drinking Behavior; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections; Male; Morphine; Rats; Rats, Inbred Strains | 1984 |
Adrenergic mediation of the intestinal antisecretory action of opiates administered into the central nervous system.
Topics: Animals; Blood Pressure; Brain; Cholera Toxin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Injections, Intraventricular; Intestinal Mucosa; Male; Morphine; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Tyramine | 1984 |
Stereospecific inhibition by naloxone of histamine-stimulated acid secretion in isolated guinea pig parietal cells.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gastric Acid; Guinea Pigs; Histamine; In Vitro Techniques; Male; Naloxone; Parietal Cells, Gastric; Stereoisomerism | 1984 |
In vivo modulation of intestinal motility and sites of opioid effects in the rat.
Topics: Animals; Electrophysiology; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Gastrointestinal Motility; Intestine, Small; Male; Rats; Rats, Inbred Strains | 1984 |
[Effect of ethanol on the enkephalinergic opioid system of the rat brain].
Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethanol; Male; Morphine; Neprilysin; Protein Binding; Rats | 1984 |
Cell-cycle dependence of a ganglioside glycosyltransferase activity and its inhibition by enkephalin in a neurotumor cell line.
Topics: Animals; Cell Cycle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; G(M2) Ganglioside; G(M3) Ganglioside; Galactosyltransferases; Gangliosides; Glioma; Hybrid Cells; Kinetics; Mice; N-Acetylgalactosaminyltransferases; Neuroblastoma; Rats | 1984 |
Opioid peptides and self-stimulation of the medial prefrontal cortex in the rat.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Injections, Intraventricular; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Self Stimulation | 1984 |
[Effect of enkephalins on vasopressin and aldosterone levels in acute experimental myocardial ischemia].
Topics: Aldosterone; Animals; Coronary Disease; Diuresis; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Rats; Vasopressins | 1984 |
[Anti-stress effect of D-Ala2-Leu5-Arg6-enkephalin].
Topics: Adrenal Glands; Animals; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Organ Size; Plant Extracts; Rats; Spleen; Stress, Physiological; Thymus Gland | 1984 |
[Modulation of the proliferative response of lymphocytes with a new enkephalin analog--dalargin].
Topics: Arthritis, Rheumatoid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Lupus Erythematosus, Systemic; Lymphocyte Activation; Lymphopenia; Oligopeptides | 1984 |
Effect of enkephalin on the micturition cycle of the cat.
Topics: Animals; Brain Stem; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Spinal Cord; Urinary Bladder; Urination | 1984 |
The inhibitory effect of opioid peptides and morphine applied intrathecally and intracerebroventricularly on the micturition reflex in the cat.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Morphine; Naloxone; Oligopeptides; Reflex; Thiorphan; Tiopronin; Urination | 1984 |
[1st experiment in the clinical use of the Soviet synthetic peptide, dalargin in patients with ischemic heart disease].
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Dose-Response Relationship, Drug; Drug Evaluation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Hemodynamics; Humans; Middle Aged; Myocardial Contraction; Stroke Volume | 1983 |
Simultaneous measurement of cholecystokinin- and vasoactive intestinal polypeptide-like immunoreactivity from cat frontal cortex in vitro: effect of morphine and D-Ala2-D-Leu5-enkephalin.
Topics: Animals; Cats; Cholecystokinin; Dextrorphan; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Levorphanol; Morphine; Naloxone; Potassium; Vasoactive Intestinal Peptide | 1984 |
Pharmacological characterization of opioid effects in the rat hippocampal slice.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Hippocampus; In Vitro Techniques; Morphine; Naloxone; Narcotics; Pyramidal Tracts; Rats; Synapses | 1982 |
Tolerance and cross tolerance to morphine after chronic spinal D-Ala2-D-Leu5-enkephalin infusion.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Infusions, Parenteral; Injections, Spinal; Male; Morphine; Rats; Rats, Inbred Strains; Spinal Cord | 1982 |
Enkephalin dipeptidyl carboxypeptidase (enkephalinase) activity: selective radioassay, properties, and regional distribution in human brain.
Topics: Aged; Animals; Brain; Edetic Acid; Endopeptidases; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Methods; Mice; Neprilysin; Species Specificity; Substrate Specificity; Tissue Distribution; Zinc | 1982 |
Effects of Met-enkephalin and naloxone on gastric emptying and secretion in rhesus monkeys.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gastric Emptying; Gastric Juice; Hydrogen-Ion Concentration; Macaca mulatta; Male; Naloxone | 1983 |
Enkephalin and fear-motivated behavior.
Topics: Animals; Avoidance Learning; Behavior, Animal; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Fear; Light; Male; Pain; Perception; Rats; Sensory Thresholds; Visual Perception; Water | 1980 |
Effects of intraventricular morphine and enkephalins on locomotor activity in nondependent, morphine-dependent and postdependent rats.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Rats; Time Factors | 1981 |
The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.
Topics: Animals; Behavior, Animal; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flupenthixol; Globus Pallidus; Male; Motor Activity; Naloxone; Organ Specificity; Rats; Tegmentum Mesencephali | 1981 |
Possible mechanisms of enkephalin action on hippocampal CA1 pyramidal neurons.
Topics: Animals; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Naloxone; Neurons; Pyramidal Tracts; Rats; Synapses | 1981 |
Dopamine and [D-ALA2, D-Leu5]enkephalin inhibit the electrically stimulated neurohypophyseal release of vasopressin in vitro: evidence for calcium-dependent opiate action.
Topics: Animals; Arginine Vasopressin; Calcium; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Neurosecretion; Parasympathomimetics; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains | 1982 |
Stimulation of drinking behaviour and of renin release induced by intracerebroventricular injections of D-Ala2,D-Leu5-enkephalin to rats.
Topics: Animals; Atropine; Drinking Behavior; Drug Interactions; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Phentolamine; Rats; Rats, Inbred Strains; Renin | 1982 |
Depression of learned thermoregulatory behavior by central injection of opioids in cats.
Topics: Animals; Avoidance Learning; Body Temperature Regulation; Cats; Conditioning, Operant; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Morphine; Motor Activity; Pentazocine | 1982 |
Behavioural data on dermorphins in mice.
Topics: Animals; Behavior, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Motor Activity; Oligopeptides; Opioid Peptides; Reaction Time | 1982 |
Elevation of arterial blood pressure in conscious dogs by Des-Tyr1-D-Ala2-leucine-enkephalinamide.
Topics: Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Pressoreceptors; Respiration | 1982 |
Effects of intraventricular morphine and enkephalins on schedule-controlled behavior in nondependent, morphine-dependent and postdependent rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1981 |
To the problem of biologically active conformation of enkephalin.
Topics: Analgesics; Animals; Burns; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Models, Molecular; Morphine; Protein Conformation; Rats; Structure-Activity Relationship | 1981 |
Behavioural and EEG studies on an anaesthetic enkephalin peptide [proceedings].
Topics: Anesthetics; Animals; Behavior, Animal; Electroencephalography; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Hormones; Male; Mice; Rabbits; Rats | 1980 |
Regulation of L-valine absorption by opioids interacting with mu-receptors in rabbit ileum.
Topics: Analgesics; Animals; Body Water; Chlorides; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ileum; In Vitro Techniques; Intestinal Absorption; Kinetics; Male; Membrane Potentials; Morphine; Muscle, Smooth; Naloxone; Rabbits; Receptors, Opioid, mu; Sodium; Time Factors; Valine | 1995 |
Anti-idiotypic antibodies: a useful alternative for studying the biochemical expression of mu/delta opioid binding sites in mammalian brain.
Topics: Animals; Antibodies, Anti-Idiotypic; Binding Sites; Brain Chemistry; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Immunoblotting; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1995 |
IL-1 beta-like Freund's adjuvant enhances axonal transport of opiate receptors in sensory neurons.
Topics: Animals; Axonal Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Interleukin-1; Ligation; Male; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve | 1994 |
Leucine enkephalin effects on paracellular and transcellular permeation pathways across brain microvessel endothelial cell monolayers.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Blood-Brain Barrier; Cattle; Cell Membrane Permeability; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Endothelium, Vascular; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fluorescein-5-isothiocyanate; Fluorescence Polarization; Lanthanum; Microcirculation; Microscopy, Electron; Molecular Sequence Data; Molecular Weight | 1994 |
Synthesis and opioid activities of [D-Leu-8]Dynorphin(1-8) analogs containing a reduced peptide bond, psi(CH2-NH).
Topics: Amino Acid Sequence; Analgesics; Animals; Binding, Competitive; Cerebellum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Opioid Peptides; Receptors, Opioid | 1995 |
Heterologous desensitization of opioid-stimulated Ca2+ increase by bradykinin or ATP in NG108-15 cells.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Inositol 1,4,5-Trisphosphate; Neuroblastoma; Receptors, Opioid, delta; Tumor Cells, Cultured | 1995 |
Dalargin and [Cys-(O2NH2)]2 analogues of enkephalins and their selectivity for mu opioid receptors.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Naloxone; Receptors, Opioid, mu; Sympatholytics; Tetrodotoxin | 1995 |
Delta, mu and kappa opioid receptor agonists inhibit dopamine overflow in rat neostriatal slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Neostriatum; Nomifensine; Oligopeptides; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Expression of functional delta opioid receptors in Xenopus oocytes.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Glioma; Hybrid Cells; Isoproterenol; Mice; Naltrexone; Neuroblastoma; Oocytes; Poly A; Rats; Receptors, Opioid, delta; RNA; RNA, Messenger; Xenopus laevis | 1993 |
Presence in neuroblastoma cells of a mu 3 receptor with selectivity for opiate alkaloids but without affinity for opioid peptides.
Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; NAD; Neuroblastoma; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Evidence for functional delta-opiate receptors in the rat intestine.
Topics: Acetylcholine; Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Jejunum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 1994 |
[The effect of opioid peptides on a decreased proliferation and on an increased maturation rate of glioma C-6 cells manifested by enhanced marker enzyme activity].
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Glutamate-Ammonia Ligase; Phenotype; Rats; Time Factors; Tumor Cells, Cultured | 1994 |
[Opiate-ergic mechanisms of the cardiotropic effect of acute cooling].
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypothermia, Induced; In Vitro Techniques; Injections, Intraventricular; Male; Myocardial Contraction; Rats; Rats, Wistar; Receptors, Opioid, mu; Receptors, sigma | 1994 |
Conserved delta-activity in reverse enantiomeric opioid peptide.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Male; Mice; Molecular Sequence Data; Opioid Peptides; Protein Conformation; Rabbits; Receptors, Opioid, delta; Structure-Activity Relationship | 1995 |
Mimics of the binding sites of opioid receptors obtained by molecular imprinting of enkephalin and morphine.
Topics: alpha-Endorphin; Amino Acid Sequence; Binding Sites; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Morphine; Oligopeptides; Receptors, Opioid | 1995 |
Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes.
Topics: Analgesics; Animals; Base Sequence; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Molecular Sequence Data; Morphine; Oligonucleotides, Antisense; Rats; Receptors, Opioid, delta | 1995 |
Stimulatory effect of opioid peptides and naloxone on rat spinal cord cells in primary dissociated culture.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Molecular Sequence Data; Naloxone; Nerve Growth Factors; Rats; Rats, Wistar; Spinal Cord; Stimulation, Chemical | 1994 |
[Participation of central opiate receptors in the pathogenesis of adrenal arrhythmias].
Topics: Adrenal Gland Diseases; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Wistar; Receptors, Opioid | 1994 |
Identification and characterization of opioid-binding sites present in the Ishikawa human endometrial adenocarcinoma cell line.
Topics: Acids; Adenocarcinoma; Binding Sites; Endometrial Neoplasms; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Humans; Narcotics; Tumor Cells, Cultured | 1995 |
Influence of hypertension development on rat tail artery responses to opioid peptides.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Tail; Vasoconstriction | 1995 |
Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Barium Compounds; Cadmium; Carbachol; Chlorides; Computer Simulation; Dynorphins; Electrophysiology; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Models, Neurological; Naloxone; Narcotics; Neurons; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Maintenance of glial plasticity with aging in C-6 glial cells and normal astrocytes in culture: responsiveness to opioid peptides.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amino Acid Sequence; Animals; Astrocytes; Cellular Senescence; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Glutamate-Ammonia Ligase; Mice; Mice, Inbred C3H; Molecular Sequence Data; Nerve Tissue Proteins; Neuroglia; Neuronal Plasticity; Oligodendroglia; Tumor Cells, Cultured | 1993 |
Dissimilar efficacy of opioids to produce mu-mediated analgesia: role of Gx/z and Gi2 transducer proteins.
Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Cell Membrane; Cerebral Ventricles; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Immunoglobulin G; Injections, Intraventricular; Kinetics; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Pain; Peptide Fragments; Receptors, Opioid, mu; Signal Transduction | 1994 |
Mastoparan reduces the supraspinal analgesia mediated by mu/delta-opioid receptors in mice.
Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Male; Mice; Molecular Sequence Data; Peptides; Receptors, Opioid; Wasp Venoms | 1994 |
Evidence for chemical differentiation of delta opioid receptor subtypes by the sulfhydryl reagent N-ethylmaleimide.
Topics: Affinity Labels; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Isothiocyanates; Male; Mice; Naltrexone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
Amino acids and peptides. XXIV. Preparation and antinociceptive effect of [D-Ala2,(N-Me)Phe4]enkephalin analog-poly(ethylene glycol) hybrids.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Nociceptors; Polyethylene Glycols | 1994 |
Neurotensin, substance P, delta and mu opioid receptors are decreased in basal ganglia of Parkinson's disease patients.
Topics: Adult; Aged; Amino Acid Sequence; Analgesics; Basal Ganglia; Biogenic Monoamines; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Humans; In Vitro Techniques; Male; Middle Aged; Molecular Sequence Data; Parkinson Disease; Receptors, Neurokinin-1; Receptors, Neurotensin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density?
Topics: Adenylyl Cyclase Inhibitors; Animals; Base Sequence; CHO Cells; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Sequence Data; Receptors, Opioid, delta; RNA, Messenger; Transfection | 1994 |
Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cerebral Ventricles; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression; GTP-Binding Proteins; In Situ Hybridization; Infusions, Parenteral; Male; Naltrexone; Narcotics; Oligonucleotide Probes; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Immunoglobulin G; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Morphine; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Protein Binding; Reaction Time; Receptors, Opioid, delta | 1994 |
Responses of rat nucleus submedius neurons to enkephalins applied with micropressure.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Membrane Potentials; Micromanipulation; Naloxone; Neurons; Pain; Pressure; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Thalamic Nuclei | 1993 |
Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid, delta | 1994 |
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Fura-2; Glioma; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Microscopy, Fluorescence; Naloxone; Narcotics; Neuroblastoma; Pyrrolidines; Rats; Tumor Cells, Cultured | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Long-term changes in striatal opioid systems after 6-hydroxydopamine lesion of rat substantia nigra.
Topics: Animals; Corpus Striatum; Dopamine; Down-Regulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression Regulation; Male; Mazindol; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Opioid; RNA, Messenger; Substantia Nigra; Time Factors | 1993 |
mu opiate receptor: cDNA cloning and expression.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escherichia coli; Gene Expression; Humans; Kinetics; Molecular Sequence Data; Polymerase Chain Reaction; Protein Biosynthesis; Rats; Receptors, Opioid, mu; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid | 1993 |
Inhibitory effects of NaCl and guanyl-5'yl-imidodiphosphate (GppNHp) on [3H]naloxone binding to kappa-opioid receptors in guinea pig cerebellum.
Topics: Animals; Benzeneacetamides; Binding Sites; Cerebellum; Cerebral Cortex; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Guanylyl Imidodiphosphate; Guinea Pigs; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sodium Chloride | 1993 |
Beta-endorphin is a potent inhibitor of thymidine incorporation into DNA via mu- and kappa-opioid receptors in fetal rat brain cell aggregates in culture.
Topics: Animals; beta-Endorphin; Brain; Cell Aggregation; Cells, Cultured; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fetus; Kinetics; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thymidine; Tritium | 1993 |
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Analgesics; Animals; Binding, Competitive; Bombesin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Naltrexone; Oximes; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa | 1993 |
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens.
Topics: Animals; Benzylidene Compounds; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Thiocyanates; Vas Deferens | 1993 |
Autoradiographic evidence for decrease in binding of mu- and delta-opioid receptors after subchronic [D-Ala2,D-Leu5]enkephalin treatment in rats.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Caudate Nucleus; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ligands; Male; Mesencephalon; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
Effect of delta-opioid antagonists on the functional coupling between opioid receptors and G-proteins in rat brain membranes.
Topics: Adenylate Cyclase Toxin; Amino Acid Sequence; Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Membranes; Molecular Sequence Data; Oligopeptides; Pertussis Toxin; Rats; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1993 |
Purification and reconstitution of the delta opioid receptor.
Topics: Animals; Cattle; Cerebral Cortex; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme-Linked Immunosorbent Assay; Precipitin Tests; Receptors, Opioid, delta; Tumor Cells, Cultured | 1993 |
Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens.
Topics: Analgesics; Animals; Anticonvulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Naltrexone; Oligopeptides; Pyrroles; Receptors, Opioid, delta; Thiophenes; Vas Deferens | 1993 |
The peristaltic reflex in the rat ileum: evidence for functional mu- and delta-opiate receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidiarrheals; Diphenoxylate; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ileum; Linear Models; Loperamide; Morphine; Peristalsis; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Opioid peptides in the nervous system of Aplysia: a combined biochemical, immunocytochemical, and electrophysiological study.
Topics: Analgesics, Opioid; Animals; Aplysia; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ganglia, Invertebrate; Immunohistochemistry; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Organ Specificity; Patch-Clamp Techniques; Receptors, Opioid | 1995 |
Differential blockade of morphine and morphine-6 beta-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Base Sequence; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Male; Microinjections; Molecular Sequence Data; Morphine; Morphine Derivatives; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1995 |
Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzodiazepines; Binding, Competitive; Brain; Cerebral Cortex; Computer Graphics; Conserved Sequence; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Humans; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Pancreas; Protein Conformation; Radioligand Assay; Rats; Receptors, Cholecystokinin; Receptors, Opioid, kappa; Sequence Homology, Amino Acid; Sincalide; Structure-Activity Relationship | 1996 |
Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat.
Topics: Animals; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hot Temperature; Injections, Intraventricular; Male; Medulla Oblongata; Morphine; Nociceptors; Oligopeptides; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reticular Formation | 1995 |
Analysis of inverse agonism at the delta opioid receptor after expression in Rat 1 fibroblasts.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA, Complementary; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Proteins; Mice; Molecular Sequence Data; Narcotic Antagonists; Pertussis Toxin; Rats; Receptors, Opioid, delta; Sensitivity and Specificity; Transfection; Virulence Factors, Bordetella | 1996 |
Processing of Leu-enkephalin by rat hepatocytes.
Topics: Animals; Biological Transport; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Liver; Radioisotope Dilution Technique; Rats; Tritium | 1996 |
Separation of biologically active peptides by capillary electrophoresis and high-performance liquid chromatography.
Topics: Amino Acid Sequence; Buffers; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Oligopeptides | 1996 |
Substance P-induced respiratory excitation is blunted by delta-receptor specific opioids in the rat medulla oblongata.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Injections; Medulla Oblongata; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Respiratory Mechanics; Substance P | 1996 |
[Cys(O2NH2)2]enkephalin analogues and dalargin: selectivity for delta-opioid receptors.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Norepinephrine; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1996 |
[The realization of food-acquisition behavior in rats against a background of multiple injections of enkephalin-like peptides into the neostriatum].
Topics: Animals; Conditioning, Classical; Enkephalin, Leucine-2-Alanine; Enkephalins; Feeding Behavior; Male; Microinjections; Neostriatum; Rats; Rats, Wistar; Time Factors | 1996 |
Calcium influx in rat thalamic relay neurons through voltage-dependent calcium channels is inhibited by enkephalin.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Ion Channel Gating; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Thalamus | 1995 |
The relevance of intact enkephalin molecule in predominantly delta opioid receptor mediated superoxide anion release.
Topics: Adult; Anions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Neprilysin; Neutrophils; Oligopeptides; Protease Inhibitors; Receptors, Opioid, delta; Superoxides; Thiorphan | 1995 |
The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors.
Topics: Adenocarcinoma; Amino Acid Sequence; Binding Sites; Breast Neoplasms; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Opioid Peptides; Receptors, Opioid; Tumor Cells, Cultured | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene.
Topics: Allylamine; Analgesics, Opioid; Animals; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Isonipecotic Acids; Meperidine; Parasympatholytics; Phenols; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Metabolism of enkephalins in head membranes of the leech Theromyzon tessulatum by peptidases: isolation of an enkephalin-degrading aminopeptidase.
Topics: Aminopeptidases; Animals; Binding Sites; Chromatography, High Pressure Liquid; Detergents; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hydrolysis; Kinetics; Leeches; Octoxynol; Polyethylene Glycols | 1996 |
Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide).
Topics: Amino Acid Sequence; Binding, Competitive; Breast Neoplasms; Caseins; Cell Division; Cell Line; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Humans; Kinetics; Peptide Fragments; Receptors, Opioid, kappa | 1996 |
Role of kappa opioid receptors in modulating cholinergic twitches in the circular muscle of guinea-pig colon.
Topics: Acetylcholine; Animals; Colon; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Cholinergic; Receptors, Opioid, kappa | 1996 |
[The interaction of the renin-angiotensin and enkephalinergic systems of the brain and hypophysis in normal rats and in experimental pathology of the hypothalamo-hypophyseal-adrenal complex].
Topics: Adrenalectomy; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Brain Chemistry; Captopril; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamo-Hypophyseal System; Male; Pituitary Gland; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Opioid; Renin-Angiotensin System; Time Factors | 1996 |
Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fetal Blood; Mice; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Mu and delta opioid receptor activation inhibits omega-conotoxin-sensitive calcium channels in a voltage- and time-dependent mode in the human neuroblastoma cell line SH-SY5Y.
Topics: Barium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Neuroblastoma; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1997 |
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80)
Topics: Animals; Benzamides; Binding, Competitive; Brain; Crystallography, X-Ray; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Molecular Structure; Muscle Contraction; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Vas Deferens | 1997 |
Analysis of the role of delta opioid receptors in gastroprotection in the rat.
Topics: Analgesics; Animals; Binding Sites; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; Gastric Mucosa; Ileum; Male; Mice; Mice, Inbred Strains; Morphine; Muscle, Smooth; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Stomach; Stomach Diseases; Vas Deferens | 1997 |
Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat.
Topics: Analgesics; Animals; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Microinjections; Pain; Phenazocine; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Serotonin Receptor Agonists | 1997 |
Differences in the hydrolysis of enkephalin congeners by the two domains of angiotensin converting enzyme.
Topics: Analgesics, Opioid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Kinetics; Peptidyl-Dipeptidase A | 1997 |
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 1997 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
[Effect of opiate receptor ligands on the morpho-functional state of the sympathico-adrenal system and electrical stability of the heart in acute exposure to cold].
Topics: Adrenal Glands; Animals; Cold Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart; Histocytochemistry; Ligands; Myocardium; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sympathetic Nervous System; Ventricular Fibrillation | 1997 |
[Effect of mu- and delta-opiate receptor agonists on cell division in epithelium of retina and tongue of albino rats].
Topics: Animals; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epithelial Cells; Male; Pigment Epithelium of Eye; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Tongue | 1994 |
Use of "natural" hibernation induction triggers for myocardial protection.
Topics: Analysis of Variance; Animals; Coronary Circulation; Disease Models, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Heart; Heart Arrest, Induced; Hibernation; Hypothermia, Induced; Male; Marmota; Myocardial Ischemia; Myocardial Stunning; Myocardium; Oxygen Consumption; Peptides; Premedication; Proteins; Rabbits; Receptors, Opioid, delta; Ursidae; Ventricular Function; Ventricular Function, Left; Ventricular Pressure | 1997 |
Regulation of spontaneous activity of the delta-opioid receptor: studies of inverse agonism in intact cells.
Topics: Adenine; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cholera Toxin; Clone Cells; Colforsin; Cyclic AMP; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Mice; Naloxone; Narcotic Antagonists; Pertussis Toxin; Rats; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1997 |
Mobilization of Ca2+ from intracellular stores in transfected neuro2a cells by activation of multiple opioid receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Mice; Receptors, Opioid; Transfection | 1997 |
The effects of postmortem delay on mu, delta and kappa opioid receptor subtypes in rat brain and guinea pig cerebellum evaluated by radioligand receptor binding.
Topics: Animals; Benzeneacetamides; Brain; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Kinetics; Male; Naloxone; Postmortem Changes; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1997 |
Mutagenesis of the mouse delta opioid receptor converts (-)-buprenorphine from a partial agonist to an antagonist.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cells, Cultured; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Mice; Mutagenesis; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1998 |
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Topics: Affinity Labels; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fentanyl; Melphalan; Membrane Proteins; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; Stereoisomerism | 1998 |
Enkephalins modulate differentiation of normal human keratinocytes in vitro.
Topics: beta-Endorphin; Cell Differentiation; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Humans; Keratinocytes; Keratins; Melphalan; Naltrexone; Narcotic Antagonists; Skin; Transglutaminases | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Effects of various protease inhibitors on the stability and permeability of [D-Ala2,D-Leu5]enkephalin in the rat intestine: comparison with leucine enkephalin.
Topics: Animals; Cell Membrane Permeability; Drug Stability; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Protease Inhibitors; Rats; Rats, Wistar | 1998 |
In vivo assessment of opioid agonists and antagonists on ovarian maturation in the red swamp crayfish, Procambarus clarkii.
Topics: Animals; Astacoidea; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Naloxone; Narcotic Antagonists; Ovary; Receptors, Opioid, delta | 1996 |
Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C.
Topics: Analgesics, Opioid; Animals; COS Cells; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Inositol Phosphates; Ligands; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases | 1998 |
Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.
Topics: Analgesics, Opioid; Antibody Specificity; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Enzyme Inhibitors; Indoles; Morphine; Neuroblastoma; Neurons; Phosphorylation; Precipitin Tests; Pyrroles; Receptors, Opioid, mu; Tumor Cells, Cultured | 1998 |
Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain.
Topics: Analgesics, Opioid; Animals; Binding Sites; Brain; Brain Chemistry; Buprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ligands; Oligonucleotides, Antisense; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence.
Topics: Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Dynamins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; Immunohistochemistry; Microscopy, Confocal; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Signal Transduction; Stimulation, Chemical | 1999 |
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 1998 |
Kappa1-opioid binding sites are the dominant opioid binding sites in surgical specimens of human pheochromocytomas and in a human pheochromocytoma (KAT45) cell line.
Topics: Analgesics, Opioid; Binding Sites; Binding, Competitive; Catecholamines; Cell Membrane; Diprenorphine; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epinephrine; Ethylketocyclazocine; Humans; Narcotic Antagonists; Norepinephrine; Opioid Peptides; Pheochromocytoma; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium; Tumor Cells, Cultured | 1999 |
Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
Topics: Animals; Caco-2 Cells; Cell Membrane Permeability; Chemical Phenomena; Chemistry, Physical; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Stability; Humans; Peptides, Cyclic; Phenylpropionates; Prodrugs; Protein Conformation; Rats | 1999 |
Stimulation of phospholipase C by the cloned mu, delta and kappa opioid receptors via chimeric G alpha(q) mutants.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cloning, Molecular; COS Cells; DNA, Complementary; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Type C Phospholipases | 1999 |
Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoantibodies; Biological Transport; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epitopes; GTP-Binding Protein alpha Subunits, Gi-Go; Immunoblotting; Immunoglobulin G; Injections, Intraventricular; Iodine Radioisotopes; Male; Mice; Mice, Inbred Strains; Microscopy, Immunoelectron; Morphine; Neurons; Nociceptors; Oligopeptides; Pain; Protein Kinase C; Signal Transduction | 1999 |
Binding properties of C-truncated delta opioid receptors.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Peptide Fragments; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
[Effects leu-enkephalin and dalargin on the cardiac activity in rats during stimulation of postganglionic sympathetic fibers with low frequency impulses].
Topics: Animals; Autonomic Fibers, Postganglionic; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Myocardial Contraction; Rats; Stroke Volume | 1999 |
[Anxiolytic effect of dalargin on rat behavior in the Vogel conflict test and the raised cross-like labyrinth].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Conflict, Psychological; Drinking Behavior; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Motor Activity; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Water Deprivation | 1999 |
Enkephalin regulates acute D2 dopamine receptor antagonist-induced immediate-early gene expression in striatal neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Corpus Striatum; DNA Primers; DNA-Binding Proteins; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Early Growth Response Protein 1; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; In Situ Hybridization; Male; Molecular Sequence Data; Naloxone; Neurons; Oligopeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Salicylamides; Transcription Factors; Transcriptional Activation | 1999 |
[Effects of opioid peptides on ischemic myocardial arrhythmias during laser irradiation and disturbed heart sympathetic innervation].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Heart; Lasers; Male; Myocardial Ischemia; Myocardium; Opioid Peptides; Receptors, Opioid; Sympathectomy | 1999 |
Comparison of cardiovascular responses to intra-hippocampal mu, delta and kappa opioid agonists in spontaneously hypertensive rats and isolation-induced hypertensive rats.
Topics: Analgesics; Animals; Cardiovascular System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hippocampus; Hypertension; Male; Opioid Peptides; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers.
Topics: Amino Acid Sequence; Cell Membrane Permeability; Chemical Phenomena; Chemistry, Physical; Coumaric Acids; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Esterases; Membranes, Artificial; Models, Biological; Opioid Peptides; Peptides, Cyclic; Permeability; Phenylpropionates; Prodrugs; Structure-Activity Relationship | 1999 |
Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker.
Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Esterases; Opioid Peptides; Peptides, Cyclic; Prodrugs | 1999 |
The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability.
Topics: Biological Transport; Cell Membrane Permeability; Cells, Cultured; Circular Dichroism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Magnetic Resonance Spectroscopy; Models, Molecular; Opioid Peptides; Peptides, Cyclic; Prodrugs; Protein Conformation; Structure-Activity Relationship | 1999 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Evoked Potentials; Female; Ganglia, Spinal; Male; Neurons; Nimodipine; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1999 |
Optimizing oral absorption of peptides using prodrug strategies.
Topics: Administration, Oral; Caco-2 Cells; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Intestinal Absorption; Peptides; Peptides, Cyclic; Prodrugs | 1999 |
Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family.
Topics: Amino Acid Sequence; Animals; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glycopeptides; Glycosylation; Humans; In Situ Hybridization; Inhibitory Concentration 50; Male; Metalloendopeptidases; Mice; Molecular Sequence Data; Neprilysin; Organ Specificity; Protein Processing, Post-Translational; RNA, Messenger; Sequence Alignment; Solubility; Subtilisin; Testis; Thiorphan; Transfection; Zinc | 2000 |
Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Cholera Toxin; Cyclic AMP; Dextrorphan; Enkephalin, Leucine-2-Alanine; Enkephalins; Epithelial Cells; Excitatory Amino Acid Antagonists; Fetus; Intestinal Secretions; Intestines; Kinetics; Levorphanol; Naltrexone; Narcotic Antagonists; Neprilysin; Protease Inhibitors; Rats; Receptors, Opioid, delta; Stereoisomerism; Thiorphan; Tritium | 2000 |
Development of novel lipophilic derivatives of DADLE (leucine enkephalin analogue): intestinal permeability characateristics of DADLE derivatives in rats.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Colon; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Half-Life; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Lipids; Membranes; Rats | 2000 |
Supraspinal delta- and mu-opioid receptors mediate gastric mucosal protection in the rat.
Topics: Animals; beta-Endorphin; Brain; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Hydrochloric Acid; Male; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Stomach Ulcer; Vagotomy | 2001 |
Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.
Topics: Animals; Autonomic Nervous System; Cats; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gallbladder; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Neural Inhibition; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 2001 |
Crystal structure of biphalin sulfate: a multireceptor opioid peptide.
Topics: Binding Sites; Crystallography, X-Ray; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen Bonding; Naltrexone; Narcotics; Oligopeptides; Pliability; Protein Conformation; Protein Folding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Substrate Specificity; Tetrahydroisoquinolines | 2002 |
Angiotensin 1-9 and 1-7 release in human heart: role of cathepsin A.
Topics: Angiotensin I; Animals; Arachidonic Acid; Bradykinin; Carboxypeptidases; Cathepsin A; Cells, Cultured; CHO Cells; Cricetinae; Endothelium, Vascular; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Atria; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Myocardium; Nitric Oxide; Peptide Fragments; Peptide Hydrolases | 2002 |
New development in the tritium labelling of peptides and proteins using solid catalytic isotopic exchange with spillover-tritium.
Topics: Amino Acid Sequence; Animals; Brain; Catalysis; Conotoxins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Galactosidases; Hydrogen; Isotope Labeling; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Peptaibols; Peptides; Proteins; Radioligand Assay; Rats; Receptors, Opioid; Temperature; Tritium | 2003 |
[Ischemic preconditioning of the heart can be simulated by pharmacologic hibernation enkephalins].
Topics: Animals; Enkephalin, Leucine-2-Alanine; Enkephalins; Hibernation; Ischemic Preconditioning, Myocardial; Male; Perfusion; Rats; Rats, Wistar; Receptors, Opioid, delta | 1998 |
A possible role for an enkephalinergic system in the internal defense mechanism of Biomphalaria alexandrina exposed to Schistosoma mansoni.
Topics: Animals; Biomphalaria; Blood Cell Count; Disease Susceptibility; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hemocytes; Host-Parasite Interactions; Naloxone; Narcotic Antagonists; Phagocytosis; Receptors, Opioid; Schistosoma mansoni | 2003 |
The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu(5)]-enkephalin from coumarin prodrug moieties.
Topics: Coumarins; Enkephalin, Leucine-2-Alanine; Enkephalins; Esterases; Kinetics; Molecular Structure; Prodrugs | 2004 |
Delta-opioid receptor antagonists exhibit properties of partial delta-receptor agonists in isolated perfused heart.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Naltrexone; Oligopeptides; Perfusion; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta | 2004 |
Analysis and separation of enkephalin and dalargin analogues and fragments by capillary zone electrophoresis.
Topics: Electrolytes; Electrophoresis, Capillary; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; Microchemistry; Molecular Weight; Peptide Fragments; Sensitivity and Specificity | 2005 |
Diastereomeric differentiation of peptides with CuII and FeII complexation in an ion trap mass spectrometer.
Topics: Copper; Electrochemistry; Enkephalin, Leucine-2-Alanine; Enkephalins; Iron; Mass Spectrometry; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2006 |
Capillary electrophoresis chemiluminescent detection system equipped with a two-step postcolumn flow interface for detection of some enkephalin-related peptides labeled with acridinium ester.
Topics: Acridines; Animals; Brain Chemistry; Buffers; Electrophoresis, Capillary; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; Luminescent Measurements; Rats; Reproducibility of Results; Succinimides | 2008 |
Effect of dalargin on DNA synthesis in the gastric mucosa of albino rats.
Topics: Animals; Cell Proliferation; DNA; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Inhibitors; Gastric Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats | 2007 |
Co-localization of hypocretin-1 and leucine-enkephalin in hypothalamic neurons projecting to the nucleus of the solitary tract and their effect on arterial pressure.
Topics: Animals; Arterial Pressure; Data Interpretation, Statistical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart Rate; Hypothalamus; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Melphalan; Microinjections; Narcotic Antagonists; Neural Pathways; Neurons; Neuropeptides; Orexins; Rats; Rats, Wistar; Solitary Nucleus; Stilbamidines | 2013 |
Crosstalk between delta opioid receptor and nerve growth factor signaling modulates neuroprotection and differentiation in rodent cell models.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Enkephalin, Leucine-2-Alanine; Enkephalins; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neuropeptides; Neuroprotective Agents; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Receptor, trkA; Receptors, Opioid, delta; Signal Transduction | 2013 |
Hydrophilic interaction liquid chromatography for dalargin separation from its structural analogues and side products.
Topics: Ammonium Compounds; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Ions; Osmolar Concentration; Peptides; Silicon Dioxide; Spectrometry, Mass, Electrospray Ionization | 2017 |
Effect of Leu-Enkephalin Analogue on the Myeloid Compartment of the Blood System in Hypothyroid White Rats under Stress Conditions.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothyroidism; Rats | 2022 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |