enkephalin, leucine has been researched along with dynorphins in 792 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 300 (37.88) | 18.7374 |
| 1990's | 276 (34.85) | 18.2507 |
| 2000's | 144 (18.18) | 29.6817 |
| 2010's | 66 (8.33) | 24.3611 |
| 2020's | 6 (0.76) | 2.80 |
| Authors | Studies |
|---|---|
| Herkenham, M; Hurd, YL | 2 |
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Armstead, WM; Leffler, CW; Mirro, R; Zuckerman, SL | 1 |
| Armstead, WM; Crofton, JT; Leffler, CW; Mirro, R; Share, L; Zuckerman, SL | 1 |
| Lightman, SL; Young, WS | 2 |
| Deviche, P; Güntürkün, O | 1 |
| Armstead, WM; Busija, DW; Leffler, CW; Mirro, R; Zuckerman, S | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T; Wada, M | 1 |
| Gravanis, A; Makrigiannakis, A; Margioris, AN; Markogiannakis, E | 1 |
| Gannon, RL; Terrian, DM | 2 |
| Cechetto, DF; Oppenheimer, SM; Saleh, T | 1 |
| Costa, M; Tonini, M; Waterman, SA | 1 |
| Ceccatelli, S; Millhorn, DE; Seroogy, KB; Terenius, L | 1 |
| Castello, ME; Nyberg, F; Silberring, J | 1 |
| Cain, CJ; Post, RM; Rosen, JB; Weiss, SR | 1 |
| Leslie, FM; Loughlin, SE; Smith, JA | 1 |
| Bot, G; Brent, PJ; Chahl, LA; Johnston, PA | 1 |
| Cheng, ZP; Gu, DY; Luo, LG; Tong, GX; Wang, ZX; Zhao, BG | 1 |
| Sparacia, A | 1 |
| Hong, JS | 1 |
| Adler, MW; Geller, EB; Handler, CM | 1 |
| Hylden, JL; Noguchi, K; Ruda, MA | 1 |
| Brown, EE; Fibiger, HC; Finlay, JM; Gerfen, CR; Hurd, YL | 1 |
| Grider, JR; Makhlouf, GM | 1 |
| Adams, ML; Brase, DA; Dewey, WL; Morris, DL | 1 |
| Bunn, SJ; Dunkley, PR | 1 |
| Armstead, WM; Busija, DW; Desiderio, DM; Leffler, CW; Mirro, R | 1 |
| Hattori, Y; Katafuchi, T; Koizumi, K | 1 |
| Pleuvry, BJ | 1 |
| Olianas, MC; Onali, P | 1 |
| Adams, JU; Holtzman, SG | 2 |
| Johnson, SM | 1 |
| Bauer, AJ; Szurszewski, JH | 1 |
| Ponomariev, D; Sarkisyan, RA; Terenius, L | 1 |
| Bayon, A; Leon-Olea, M; Piña, AL; Sanchez-Alvarez, M | 1 |
| Casellas, AM; Guardiola, H; Renaud, FL | 1 |
| Butler, B; Gunion, MW; Miller, S; Moore, RD; Morley, JE; Rosenthal, MJ; Zib, B | 1 |
| Shiotsu, G; Stein, L; Stevens, KE | 1 |
| Nyberg, F; Silberring, J | 3 |
| Cohen, Y; Jacquot, C; Orosco, M; Robert, JJ; Rouch, C | 1 |
| Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL | 1 |
| Gintzler, AR; Xu, H | 1 |
| Michaelson, DM; Oron, L; Sarne, Y | 1 |
| Hayakawa, K; Oizumi, J | 1 |
| Biggins, JA; Gibson, AM; Lauffart, B; Mantle, D; McDermott, JR | 1 |
| Kapoor, R; Willoughby, JO | 1 |
| Bergh, J; Geijer, T; Terenius, L | 1 |
| Crain, SM; Fan, SF; Shen, KF | 1 |
| Brown, AW; Chua, SC; Hennessey, KL; Hirsch, J; Kim, J; Leibel, RL | 1 |
| Hong, JS; Lee, PH; McGinty, JF; Mitchell, CL; Xie, CW | 1 |
| Kimura, F; Nishihara, M; Osada, T | 1 |
| Demuth, HU; Nyberg, F | 1 |
| Ceccatelli, S; Hökfelt, T; Meister, B; Villar, MJ | 1 |
| Gerfen, CR; McGinty, JF; Young, WS | 1 |
| Besson, MJ; Graybiel, AM; Quinn, B | 1 |
| Sivam, SP | 2 |
| Shimada, Y; Yamada, K; Yoshida, S | 1 |
| Chase, TN; Engber, TM; Gerfen, CR; Kuo, S; Susel, Z | 1 |
| Hong, JS; Jiang, HK; McGinty, JF | 1 |
| Dumont, M; Lemaire, S; Sabourin, L | 1 |
| Crain, SM; Shen, KF | 3 |
| Arts, KS; Fujimoto, J; Rady, J; Tseng, L | 1 |
| Pittman, QJ; Thornhill, JA | 1 |
| Dixon, DM; Traynor, JR | 2 |
| Caudle, RM; Chavkin, C | 1 |
| Green, IC; Khawaja, XZ; Thorpe, JR; Titheradge, MA | 1 |
| Nishimori, T; Uhl, GR | 1 |
| Hong, JS; Mitchell, CL; Xie, CW | 1 |
| Cetin, Y | 3 |
| Kameyama, T; Katoh, A; Nabeshima, T | 1 |
| Gosnell, BA; Krahn, DD; Majchrzak, MJ | 1 |
| Amerini, S; Ledda, F; Mantelli, L; Rubino, A | 1 |
| Ayala, JM; Molineaux, CJ | 1 |
| Giuliani, S; Maggi, CA; Meli, A | 1 |
| Arts, KS; Fujimoto, JM; Rady, JJ; Tseng, LF | 1 |
| Hoss, W; Periyasamy, S | 1 |
| Matsuyama, S; Nakayama, S; Ohgushi, N; Tanaka, C; Taniyama, K; Tsunekawa, K | 1 |
| Han, JS; Wang, XH; Wang, XJ | 1 |
| Amerini, S; Ledda, F; Mantelli, L | 1 |
| Herz, A; Shippenberg, TS; Spanagel, R | 1 |
| Hong, JS; Hudson, PM; Jiang, HK; Li, SJ; Nanry, K; Owyang, V; Stachowiak, MS; Tilson, HA | 1 |
| Bird, ED; Crino, PB; Plager, MD; Vogt, BA | 1 |
| Caudle, RM; Chavkin, C; Neumaier, JF; Wagner, JJ | 1 |
| Han, JS; Wang, XJ; Zhang, LJ | 1 |
| Jia, X; Kowk, YN; McIntosh, CH | 1 |
| Armstead, WM; Busija, DW; Leffler, CW; Mirro, R | 1 |
| Ikeda, K; Iwasaki, Y; Kinoshita, M; Shiojima, T | 1 |
| Di Scala-Guenot, D; Felix, JM; Richard, P; Strosser, MT | 1 |
| Hishida, F; Igarashi, O; Luo, CP; Takeshige, C | 1 |
| Baldwin, BA; de la Riva, C; Ebenezer, IS | 1 |
| Macdonald, RL; Werz, MA | 4 |
| Hazato, T; Katayama, T; Komuro, T; Shimamura, M | 1 |
| Basbaum, AI; Cruz, L; Weber, E | 1 |
| Ashida, Y; Hata, H; Makino, H; Tonoue, T | 1 |
| Bird, ED; Haber, SN; Kowall, NW; Richardson, EP; Vonsattel, JP | 1 |
| Christensson-Nylander, I; Cuello, C; Goldstein, M; Herrera-Marschitz, M; Hökfelt, T; Oertel, WH; Staines, W; Terenius, L; Ungerstedt, U | 1 |
| Bonner, TI; Brann, MR; Young, WS | 1 |
| Lkhider, M; Marcel, R; Tramu, G | 1 |
| Kaliner, MA; Logun, C; Lundgren, J; Shelhamer, JH | 1 |
| Foster, JS; Moore, RN | 1 |
| Barnes, PJ; Frossard, N | 1 |
| Chalazonitis, A; Crain, SM; Shen, KF | 1 |
| Haarmann, I; Herz, A; Höllt, V; Nikolarakis, K; Przewłocki, R | 1 |
| Chiba, T; Masuko, S | 1 |
| Calavetta, L; Devi, L; Douglass, JO; McMurray, CT | 1 |
| Gerfen, CR; Young, WS | 1 |
| Agid, Y; Benoliel, JJ; Cesselin, F; Hamon, M; Javoy-Agid, F; Legrand, JC; Mauborgne, A; Taquet, H; Tramu, G | 1 |
| Dores, RM; Richard, R; Sei, CA | 1 |
| Gallagher, M; Hong, JS; Jiang, HK; Owyang, VV | 1 |
| Basbaum, AI; Cho, HJ | 1 |
| Murphy, R; Steele, PA; Turner, CA | 1 |
| Hirooka, Y; Mitsuma, T; Nakada, K; Nogimori, T; Nomura, A | 1 |
| Garzon, J; Landahl, HD; Lee, NM | 1 |
| Nunan, L; Porreca, F; Sheldon, RJ | 1 |
| Draisci, G; Iadarola, MJ | 1 |
| Almeida, OF; Herz, A; Nikolarakis, KE; Yassouridis, A | 1 |
| Herz, A; Höllt, V; Millan, MJ; Nohr, D; Weihe, E | 1 |
| Neal, CR; Newman, SW | 1 |
| Drasner, K; Fang, FG; Fields, HL; Haws, CM; Williamson, A | 1 |
| Ho, WK; Wen, HL | 1 |
| Kumazawa, T; Minagawa, M; Mizumura, K; Sato, J | 1 |
| Gintzler, AR; Smolens, I; Xu, H | 1 |
| Han, JS; Sun, SL | 1 |
| Akita, T; Futaki, S; Kawamoto, T; Kiso, Y; Kitagawa, K; Kiyama, S; Moritoki, H | 1 |
| Brooks, AN; Finnie, AD; Haynes, NB; Lamming, GE; Yang, KP | 1 |
| Bobbioni, E; Halimi, S; Jeanrenaud, B | 1 |
| Haber, SN; Watson, SJ | 1 |
| Su, TP | 1 |
| Goldstein, A; Herman, BH | 1 |
| Barr, E; Leslie, SW | 1 |
| Moises, HC; Walker, JM | 1 |
| Grossman, A; Sutton, JR | 1 |
| Brownstein, MJ; Eiden, LE; Eskay, RL; Faden, AI; Feuerstein, G; Palkovits, M; Weber, E; Zamir, D; Zamir, N | 1 |
| Gaudreau, P; Martel, JC; Quirion, R; St-Pierre, S; Zamir, N | 1 |
| Nieber, K; Oehme, P | 1 |
| Altschuler, RA; Fex, J; Hoffman, DW; Rubio, JA; Zamir, N | 1 |
| Baskin, DS; Hosobuchi, Y; Kuroda, H; Lee, NM | 1 |
| Mergenhagen, S; Pert, CB; Ruff, MR; Wahl, SM | 1 |
| Hoffman, DW; Zamir, N | 1 |
| Quirion, R; Zamir, N | 1 |
| Costa, M; Cuello, AC; Furness, JB | 1 |
| Alessi, NE; Fitzsimmons, MD; Khachaturian, H; Lewis, ME; Munfakh, N; Watson, SJ | 1 |
| Cox, BM; Faden, AI; Jacobs, TP; Molineaux, CJ; Rosenberger, JG | 1 |
| Copolov, DL | 1 |
| Polonskiĭ, VM; Vinogradov, VA | 1 |
| Krause, JE; McKelvy, JF; Stewart, KD; White, JD | 1 |
| Christensson-Nylander, I; Nyberg, F; Ragnarsson, U; Terenius, L | 1 |
| Imura, H; Inoue, T; Kabayama, Y; Kato, Y; Matsushita, N; Ohta, H; Shimatsu, A; Tojo, K; Yanaihara, N | 1 |
| Herz, A; Millan, MJ | 1 |
| Barchas, JD; Böhlen, P; Esch, FS; Evans, CJ; Weber, E | 1 |
| Herz, A; Schiller, PW; Schulz, R; Shearman, GT | 1 |
| Wolter, HJ | 1 |
| Devi, L; Goldstein, A | 3 |
| Zamir, N | 1 |
| Cox, BM; Faden, AI; Feuerstein, G; Molineaux, CJ; Rosenberger, JG; Zerbe, RL | 2 |
| Di Chiara, G; Morelli, M | 1 |
| Agid, Y; Cesselin, F; Giraud, P; Javoy-Agid, F; Legrand, JC; Taquet, H | 1 |
| Fujimoto, JM; Higgins, MJ; Hong, JS; Hudson, PM; Tseng, LF | 1 |
| Barchas, JD; Evans, CJ; Lorenz, RG | 1 |
| Bitar, KN; Makhlouf, GM | 2 |
| Bicknell, RJ; Chapman, C; Leng, G | 1 |
| Hartschuh, W; Weber, E; Weihe, E | 1 |
| Nordström, K; Nyberg, F; Terenius, L | 1 |
| Miller, L; Rance, MJ; Shaw, JS; Traynor, JR | 1 |
| Alessi, NE; Khachaturian, H; Lewis, ME; Watson, SJ | 1 |
| Kalivas, PW; Miller, JS; Taylor, S | 1 |
| Coletti-Previero, MA; Mattras, H; Previero, A; Zwilling, R | 1 |
| Livett, BG; Marley, PD; Mitchelhill, KI | 1 |
| Falke, N; Martin, R | 1 |
| Akil, H; Dores, RM | 1 |
| Cook, L; Steinfels, GF | 1 |
| Illes, P; Starke, K; Von Kügelgen, I; Wolf, D | 1 |
| Chang, SW; Voelkel, NF | 1 |
| Baile, CA; Della-Fera, MA; McLaughlin, CL | 1 |
| Barnard, EA; Demoliou-Mason, CD | 2 |
| Illes, P; Ramme, D | 1 |
| Ishihara, K; Iwama, T; Satoh, M; Takagi, H | 1 |
| Hong, JS; Kanamatsu, T; McGinty, JF; Mitchell, CL | 1 |
| Gosnell, BA; Levine, AS; Morley, JE | 2 |
| Nyberg, F; Nylander, I; Terenius, L | 1 |
| Geppert, M; Illes, P; Jackisch, R | 1 |
| Buder, M; Fuder, H; Riers, HD; Rothacher, G | 1 |
| Brenner, AS; Geppert, M; Illes, P; Jackisch, R | 1 |
| Brownstein, MJ; Dawbarn, D; Emson, PC; Hunt, SP; Waters, CM; Zamir, N | 1 |
| Fukuda, H; Nagano, N; Oka, J; Suzuki, T | 1 |
| Di Marzo, V; Howlett, TA; Marino, G; Morris, HR; Palmisano, A; Tomlin, S | 1 |
| Imura, H; Morii, N; Nakao, K; Sakamoto, M; Suda, M; Sugawara, A | 1 |
| Demura, H; Nakagami, Y; Shizume, K; Suda, T; Sumitomo, T; Tomori, N; Ushiyama, T; Yajima, F | 1 |
| Colpaert, FC; Członkowski, A; Herz, A; Höllt, V; Millan, MH; Millan, MJ; Pilcher, CW | 1 |
| Burke, S; Civelli, O; Douglass, J; Herbert, E; Sherman, TG; Watson, SJ | 1 |
| Eriksson, RB; Moberg, U; Nyberg, F; Pernow, C | 1 |
| Kirby, GC; McQueen, DS | 1 |
| Burks, TF; Deupree, D; Hruby, V; Hsiao, S; Mosberg, HI; Porreca, F; Spencer, RL | 1 |
| Elde, RP; Sasek, CA | 1 |
| Grimes, L; Hong, JS; Kanamatsu, T; McGinty, JF; Obie, J; Sabol, S; Yoshikawa, K | 1 |
| Colombo, M; Heym, C; Kummer, W; Lang, R | 1 |
| Kwok, YN; McIntosh, HS; Nishimura, E | 1 |
| Cox, BM; Hassen, AH; Molineaux, CJ; Rosenberger, JG | 1 |
| Cheng, CH; Hon, WK; Ng, TB; Su, BX | 1 |
| Hisamitsu, T; Okada, M | 1 |
| Ishii, S; Satoh, M; Yokosawa, H | 1 |
| Castanas, E; Cazalis, M; Dayanithi, G; Giraud, P; Legros, JJ; Louis, F; Nordmann, JJ | 1 |
| Petraglia, F; Rivier, C; Vale, W | 1 |
| Hong, J; McLamb, R; Tilson, H | 1 |
| Dyer, RS; Hong, JS; Kanamatsu, T; McGinty, JF; Mitchell, CL; Obie, J | 1 |
| Acker, GR; Molineaux, C; Orlowski, M | 1 |
| Elde, RP | 1 |
| Patey, G; Rossier, J | 1 |
| Leach, RP; Titheradge, MA | 1 |
| Lipkowski, AW; Portoghese, PS; Tam, SW | 1 |
| Akita, K; Hatanaka, H; Maruyama, M; Sugino, H | 1 |
| Herkenham, M; Jacobson, AE; McLean, S; Rice, KC; Rothman, RB | 1 |
| Camargo, AC; Metters, KM; Oliveira, EB; Rossier, J; Toffoletto, O | 2 |
| Ding, XZ; Fan, SG; Han, JS | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Gosnell, BA; Grace, M; Levine, AS | 1 |
| Ibayashi, H; Kato, K; Nawata, H; Yanase, T | 1 |
| Cox, BM | 1 |
| Corti, V; Ledda, F; Mantelli, L | 1 |
| Dickenson, AH; Knox, RJ | 1 |
| Członkowski, A; Herz, A; Millan, MH; Millan, MJ | 1 |
| Harada, H; Misawa, H; Nozaki, M; Takagi, H; Ueda, H | 1 |
| Gaymann, W; Martin, R | 1 |
| Han, SP; Xie, GX | 1 |
| Anticich, TG; Baumeister, AA; Hawkins, MF; Higgins, TD; Moore, LL | 1 |
| Bjartell, A; Böttcher, G; Ekblad, E; Håkanson, R; Sundler, F | 1 |
| Ahmad, S; Allescher, HD; Daniel, EE; Fox, JE; Kostolanska, F | 1 |
| Dass, C; Desiderio, DM | 1 |
| De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A | 1 |
| Cassuto, J; Hedner, T | 1 |
| Basbaum, AI | 1 |
| Breese, GR; Hong, JS; Krause, JE; Mueller, RA; Napier, TC; Sivam, SP | 1 |
| Benyhe, S; Borsodi, A; Hepp, J; Khan, A; Medzihradszky, K; Simon, J; Szücs, M; Wollemann, M | 1 |
| Abou-Madi, L; Cupo, A; Eybalin, M; Pontarotti, P; Tramu, G | 1 |
| Hong, JS; Sivam, SP; Smith, DR; Takeuchi, K | 1 |
| Cox, BM; Douglass, J; Rosenberger, JG | 1 |
| Agura, V; DeWitt, DS; Faden, AI; Hayes, RL; McIntosh, TK | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; McWilliam, JR | 2 |
| Faden, AI; Head, VA; McIntosh, TK | 1 |
| Iyengar, S; Kim, HS; Wood, PL | 1 |
| Belisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Lemaire, S; Petit, A | 1 |
| Chin, YC; Jiao, HY; Liu, JS; Liu, Y | 1 |
| Akil, H; Day, R | 1 |
| Quinn, B; Weber, E | 1 |
| Breese, GR; Hong, JS; Mueller, RA; Napier, TC; Sivam, SP | 1 |
| Holaday, JW; Tortella, FC | 1 |
| Howlett, TA; Rees, LH | 1 |
| Cros, J; Gairin, JE; Jomary, C; Meunier, JC | 1 |
| McLean, S; Rothman, RB | 1 |
| Bero, LA; Kuhn, CM; Lurie, SN | 1 |
| Chavkin, C; Mailheau, S; Neumaier, JF | 1 |
| d'Amato, R; Janiri, L; Zieglgänsberger, W | 1 |
| Holtzman, SG; Ukai, M | 2 |
| Arjune, D; Bodnar, RJ; Hahn, EF; Mann, PE; Pasternak, GW; Romero, MT | 1 |
| Nahin, RL | 1 |
| Finsen, B; Poulsen, PH; Sørensen, T; Zimmer, J | 1 |
| Grider, JR; Makhlouf, GM; Severi, C | 1 |
| Herz, A; Leibold, A; Millan, MJ; Nohr, D; Weihe, E | 1 |
| Alvinerie, M; Bueno, L; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Lindberg, B; Lyrenäs, S; Nyberg, F; Terenius, L | 1 |
| Moon, TD | 1 |
| Calvetta, L; Civelli, O; Douglass, J; Herbert, E; Hong, JS; Li, S; McGinty, JF; Sivam, SP; Takeuchi, K | 1 |
| Gall, C | 1 |
| Bueno, L; Fargeas, MJ; Primi, MP | 1 |
| Gall, CM | 1 |
| Chavkin, C; Neumaier, JF; Swearengen, E | 1 |
| Civelli, O; Douglass, J; Iadarola, MJ; Naranjo, JR | 1 |
| Adler, MW; Geller, EB; Tiseo, PJ | 1 |
| Iwamoto, ET | 1 |
| Brown, MR; Crum, RL | 1 |
| Holaday, JW; Long, JB; Mobley, WC | 1 |
| Cowan, A; Mosberg, HI; Omnaas, JR; Porreca, F; Zhu, XZ | 1 |
| Clark, JA; Houghten, R; Pasternak, GW | 1 |
| Hedler, L; Schurr, C; Starke, K; Szabo, B | 1 |
| McCall, LD; Simerly, RB; Watson, SJ | 1 |
| Nilekani, SP; Nuchols, PA; Oeltgen, PR; Spurrier, WA; Su, TP | 1 |
| Douglas, J; Navia, B; Uhl, GR | 1 |
| Ansah-Yiadom, R; Claiborne, BJ; Johnston, D; Rea, MA; Strittmatter, WJ; Terrian, DM | 1 |
| Altschuler, RA; Hoffman, DW; Jones-King, KL | 1 |
| Fujiwara, M; Kurahashi, K; Okamoto, T | 1 |
| Johnson, DR; Oleson, DR | 1 |
| Basbaum, AI; Cruz, L | 1 |
| Holaday, JW; Long, JB; Petras, JM | 1 |
| Griffths, EC; McDermott, JR | 1 |
| Ghazarossian, VE; Goldstein, A | 1 |
| Chang, JK; Jen, MF; Lee, NM; Loh, HH; Tulunay, FC | 2 |
| Rubini, P; Schulz, R; Wüster, M | 1 |
| Berzas, MC; Coy, DH; Ibanez, ML; Kastin, AJ; King, BM; Olson, GA; Olson, RD; Von Almen, TK | 1 |
| Höllt, V | 1 |
| Chavkin, C; Goldstein, A; James, IF | 1 |
| Barchas, JD; Boarder, MR; Erdelyi, E | 1 |
| Akil, H; Fischli, W; Goldstein, A; Nilaver, G; van wimersma Griedanus, TB; Watson, SJ; Zimmerman, E | 1 |
| Herz, A; Höllt, V; Seizinger, BR | 3 |
| Caturay, EM; Huidobro-Toro, JP; Lee, NM; Ling, N; Loh, HH; Way, EL | 1 |
| Rossier, J | 1 |
| Asai, M; Furutani, Y; Hirose, T; Inayama, S; Kakidani, H; Morimoto, Y; Nakanishi, S; Noda, M; Numa, S; Takahashi, H | 1 |
| Corbett, AD; Kosterlitz, HW; Magnan, J; McKnight, AT; Paterson, SJ | 1 |
| Barabe, J; Day, R; Denis, D; Lemaire, S; St-Pierre, S | 1 |
| Akil, H; Watson, SJ | 1 |
| Huidobro-Toro, JP; Lee, NM; Loh, HH; Way, EL; Yoshimura, K | 1 |
| Fujino, M; Imura, H; Katakami, H; Kato, Y; Matsuo, H; Matsushita, N; Shimatsu, A | 1 |
| Tung, AS; Yaksh, TL | 1 |
| Huidobro-Toro, JP; Way, EL; Yoshimura, K | 1 |
| Blacher, R; Kilpatrick, DL; Lahm, HW; Udenfriend, S; Wahlstrom, A | 1 |
| Akil, H; Coy, DH; Goldstein, A; Khachaturian, H; Watson, SJ | 1 |
| Day, R; Dumont, M; Lemaire, S | 1 |
| Christensson, I; Hökfelt, T; Terenius, L; Vincent, SR | 1 |
| Bloom, FE; Chouvet, G; Henriksen, SJ; McGinty, J | 1 |
| Nyberg, F; Sjölund, B; Terenius, L; Wahlström, A | 1 |
| Barchas, JD; Geis, R; Voigt, KH; Weber, E | 1 |
| Cuello, AC | 1 |
| Hughes, J | 1 |
| Green, IC; Perrin, D; Ray, K | 1 |
| Ikeda, Y; Imura, H; Nakao, K; Numa, S; Sakamoto, M; Suda, M; Yanaihara, N; Yoshimasa, T | 1 |
| Hayashi, K; Ikeda, Y; Imura, H; Nakao, K; Sakamoto, M; Suda, M; Yoshimasa, T | 1 |
| Ikeda, Y; Imura, H; Jingami, H; Nakai, Y; Nakao, K; Oki, S; Sakamoto, M; Suda, M; Tanaka, I; Tsukada, T; Yoshimasa, T | 1 |
| Chavkin, C; Cox, BM | 1 |
| Herz, A | 1 |
| Barchas, JD; Cone, RI; Goldstein, A; Weber, E | 1 |
| Christensson, I; Dalsgaard, CJ; Hökfelt, VT; Terenius, L; Vincent, SR | 1 |
| Grimm, C; Herz, A; Höllt, V; Seizinger, BR | 1 |
| Fischli, W; Goldstein, A; James, IF | 1 |
| Chavkin, C; Gruol, DL; Siggins, GR; Valentino, RJ | 1 |
| Alessi, NE; Khachaturian, H; Munfakh, N; Watson, SJ | 1 |
| Beaumont, A | 1 |
| Bakhit, C; Bloom, FE; Chavkin, C; Weber, E | 1 |
| Basbaum, AI; Fields, HL | 1 |
| Bloom, FE; McGinty, JF; van der Kooy, D | 1 |
| Aronin, N; DiFiglia, M | 1 |
| Herz, A; Schulz, R; Wüster, M | 1 |
| Boudouresque, F; Cantau, P; Castanas, E; Cesselin, F; Chabrier, PE; Conte-Devolx, B; Cupo, A; Drissi, R; Eiden, LE; Giraud, P | 1 |
| Pairet, M; Ruckebusch, Y | 1 |
| Rezvani, A; Way, EL | 1 |
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| Aguilar, E; Bové, J; Cortés, R; Marin, C; Mengod, G; Serrats, J | 1 |
| Bakalkin, G; Hara, Y; Pickel, VM; Yakovleva, T | 1 |
| Buxbaum, JD; Cho, J; Jacobson, DA; Landa, LR; Philipson, LH; Roe, MW; Tamarina, NA | 1 |
| Ahmad, T; Ahmed, M; Bergström, J; Kreicbergs, A; Li, J; Spetea, M | 1 |
| Franklin, SO; Gerald, TM; Howlett, AC; Ward, GR | 1 |
| Cheng, MY; Islas, MI; Lee, AG; Leslie, FM; Loughlin, SE; Villegier, AS | 1 |
| Casalotti, SO; Dodson, H; Forge, A; Govitrapong, P; Jongkamonwiwat, N; Phansuwan-Pujito, P | 1 |
| Chen, JX; Wang, ZF; Yue, GX; Zhao, X | 1 |
| Candeletti, S; D'Addario, C; Di Benedetto, M; Furst, S; Király, KP; Landuzzi, D; Riba, P; Romualdi, P | 1 |
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| Hadjiconstantinou, M; Isola, R; Neff, NH; Tejwani, GA; Zhang, H | 2 |
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| Capper-Loup, C; Kaelin-Lang, A | 2 |
| Charron, C; Hakim, AM; Plamondon, H; Proulx, G; Schock, SC; Thompson, CS | 1 |
| Bolte, C; Newman, G; Schultz, Jel J | 1 |
| Kennedy, RT; Li, Q; Zubieta, JK | 1 |
| Al-Amin, HA; Atweh, S; El-Rawas, R; Jaber, M; Saadé, NE; Thiriet, N | 1 |
| Di Paolo, T; Grégoire, L; Lévesque, D; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P; Tamim, MK | 1 |
| Cui, CL; Han, JS; Li, YJ; Liang, J; Ma, YY; Ping, XJ; Wu, LZ | 1 |
| Chen, W; Marvizón, JC; Murphy, N | 1 |
| Aguilar, E; Cortés, R; Marin, C; Mengod, G; Obeso, JA | 1 |
| Cai, Y; Chai, Y; Chan, P; Ding, H; Li, N; Zhang, Y | 1 |
| Furuya, M; Imai, S; Inada, E; Iseki, M; Kobayashi, Y; Kuzumaki, N; Maitani, Y; Narita, M; Niikura, K; Shimizu, T; Suzuki, T; Taketa, Y; Yamazaki, M | 1 |
| Barson, JR; Chang, GQ; Chang, SY; Chen, YW; Karatayev, O; Leibowitz, SF | 1 |
| Bloch-Boguslawska, E; Kowalewski, J; Krajnik, M; Mousa, SA; Schäfer, M; Sobanski, P; Zylicz, Z | 1 |
| Földes, A; Kovács, KJ; Luisa Laorden, M; Martín, F; Núñez, C; Victoria Milanés, M | 1 |
| Burdett, TC; Cassin, JJ; Chen, JF; Fredholm, BB; Healy, B; Schwarzschild, MA; Xiao, D | 1 |
| Alijaniaram, M; Fan, T; Fletcher, PJ; George, SR; Hasbi, A; O'Dowd, BF; Perreault, ML; Seeman, P; Varghese, G | 1 |
| Artemenko, KA; Bakalkin, G; Bazov, I; Depoorter, C; Dooijes, D; Hauser, KF; Jezierska, J; Knapp, PE; Kremer, B; Nyberg, F; Sinke, RJ; Van de Warrenburg, BP; Verbeek, DS; Verschuuren-Bemelmans, C; Watanabe, H; Wijmenga, C; Yakovleva, T; Zubarev, RA | 1 |
| Friedman, TC; Hamid, A; Lutfy, K; Marquez, P; Nguyen, K; Parikh, D; Tseng, A | 1 |
| Chen, JX; Li, W; Xu, HY; Yang, JX; Zhao, X | 1 |
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| Candeletti, S; Caputi, FF; D'Addario, C; Del Borrello, E; Gandolfi, O; Rimondini, R; Romualdi, P | 1 |
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| Bakalkin, G; Bazov, I; Hussain, MZ; Kononenko, O; Kuntić, V; Nyberg, F; Sarkisyan, D; Taqi, MM; Watanabe, H; Yakovleva, T | 1 |
| Andersson, M; Bergquist, J; Fälth, M; Hanrieder, J; Ljungdahl, A | 1 |
| Henriksson, R; Shippenberg, TS; Tejeda, HA | 1 |
| Aosaki, T; Imanishi, M; Inoue, R; Kobayashi, K; Masuda, M; Miura, M; Saino-Saito, S; Takada, M | 1 |
| Hamid, A; Lutfy, K; Marquez, P; Nguyen, K; Tseng, A | 1 |
| Duchemin, AM; Hadjiconstantinou, M; McCarthy, MJ; Neff, NH | 1 |
| Campillo, A; González-Cuello, A; Laorden, ML; Puig, MM; Romero, A; Romero-Alejo, E; Vasconcelos, N | 1 |
| Banghart, MR; Sabatini, BL | 1 |
| Butelman, ER; Kreek, MJ; Yuferov, V | 1 |
| Beverley, JA; Carr, B; Steiner, H; Van Waes, V | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
| Alijaniaram, M; George, SR; Hasbi, A; O'Dowd, BF; Perreault, ML | 1 |
| Berridge, KC; DiFeliceantonio, AG; Kennedy, RT; Mabrouk, OS | 1 |
| Atashi, A; Bakhshandeh, B; Hafizi, M; Soleimani, M | 1 |
| Lyashev, YD; Solin, AV | 1 |
| Capper-Loup, C; Frey, CM; Kaelin-Lang, A; Rebell, D | 1 |
| Dunlop, SA; Farid, WO; Hulse, GK; Krstew, EV; Lawrence, AJ; Tait, RJ | 1 |
| Andren, PE; Falasca, S; Petruzziello, F; Rainer, G; Zhang, X | 1 |
| Frau, L; Morelli, M; Simola, N | 1 |
| Bérubé, P; Bhatnagar, S; Drolet, G; Laforest, S | 1 |
| Gonzalez, AD; Kahlid, S; McEwen, BS; Milner, TA; Ogawa, S; Spencer-Segal, JL; Tsuda, MC; Van Kempen, TA; Waters, EM | 1 |
| Brené, S; de la Calle, A; Díaz-Cabiale, Z; Fuxe, K; Gago, B; Reina-Sánchez, MD; Rivera, A; Roales-Buján, R; Suárez-Boomgaard, D; Valderrama-Carvajal, A | 1 |
| Bastias del Carmen Candia, S; Candeletti, S; Caputi, FF; Carretta, D; Cavina, C; D'Addario, C; Di Benedetto, M; Romualdi, P | 1 |
| Dudas, B; Grignol, G; Kiczek, M; Merchenthaler, I; Olsen, J; Peroski, M | 1 |
| Borroto-Escuela, DO; de la Calle, A; Duchou, J; Fuxe, K; Gago, B; Medina-Luque, J; Rivera, A; Roales-Buján, R; Suárez-Boomgaard, D; Valderrama-Carvajal, A; Van Craenenbroeck, K | 1 |
| Di Paolo, T; Grégoire, L; Jourdain, VA; Morin, N; Morissette, M | 1 |
| Chou, AH; Day, YJ; Lee, CM; Lee, HC; Liao, CC; Lin, YC; Liou, JT; Mao, CC | 1 |
| Chen, ZY; Fu, X; Wang, H; Xu, H; Xu, W | 1 |
| Clark, PJ; Day, HE; Fleshner, M; Ghasem, PR; Greenwood, BN; Herrera, JJ; Mika, A | 1 |
| DiLeone, RJ; Eggels, L; Fliers, E; Furman, K; Gumbs, MC; Kalsbeek, A; Kolk, SM; la Fleur, SE; Land, BB; Narayanan, NS; Opland, DM; van den Heuvel, JK | 1 |
| Brennand, KJ; Funkelstein, L; Gage, FH; Hook, V; Kim, Y; Lee, KC; Toneff, T; Ziegler, M | 1 |
| Darvas, M; Palmiter, RD | 1 |
| Garcia-Galiano, D; Leon, S; Manfredi-Lozano, M; Navarro, VM; Pinilla, L; Roa, J; Ruiz-Pino, F; Sánchez-Garrido, MA; Tena-Sempere, M | 1 |
| Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F; Yamamoto, C | 1 |
| Bordner, K; Deak, T | 1 |
| Bakalkin, G; Bazov, I; Hauser, KF; Ivanova, T; Khmyz, V; Krishtal, O; Lindskog, CJ; Maximyuk, O; Vukojević, V | 1 |
| Brodsky, M; Eskenazi, D; Neumaier, JF | 1 |
| Beaudry, F; Saidi, M | 1 |
| Bonastre, M; Cortés, R; Marin, C; Mengod, G; Rodríguez-Oroz, MC | 1 |
| Katsuyama, S; Komatsu, T; Mizoguchi, H; Nagase, H; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M | 1 |
| Kempen, TA; Milner, TA; Pickel, VM; Rogers, SA | 1 |
| Capper-Loup, C; Kaelin-Lang, A; Paganetti, P; Sgroi, S | 1 |
| Bakalkin, G; Dooley, C; Marrink, SJ; McLaughlin, J; Melo, MN; Reits, E; Sinke, RJ; Smeets, CJ; Stargardt, A; Verbeek, DS; Zmorzyńska, J | 1 |
| Barreau, F; Boué, J; Ceredig, RA; Dietrich, G; Gavériaux-Ruff, C; Reiss, D; Secher, T | 1 |
| Alkass, K; Andersson, M; Bakalkin, G; Bazov, I; Druid, H; Dyachok, O; Gerashchenko, G; Kononenko, O; Krishtal, O; Mulder, J; Rajkowska, G; Stockmeier, CA; Svenningsen, ÅF; Verbeek, DS; Watanabe, H; Yakovleva, T | 1 |
| Lyashev, AY; Lyashev, YD; Solin, AV | 1 |
| Condés-Lara, M; Gamal-Eltrabily, M; González-Hernández, A; Márquez-Morales, C; Martínez-Lorenzana, G | 1 |
| Avnor, Y; Bishop, C; Chambers, NE; Conti, MM; Gross, L; Lanza, K; Meadows, SM; Ostock, CY | 1 |
| Caffino, L; Candeletti, S; Caputi, FF; Fumagalli, F; Romualdi, P | 1 |
| Altwal, F; Beverley, JA; F Voelkner, NM; Padovan-Neto, FE; Patterson, S; Steiner, H; West, AR | 1 |
| Andrén, PE; Bezard, E; Fridjonsdottir, E; Gunnarsdottir, H; Hulme, H; Nilsson, A; Shariatgorji, R; Svenningsson, P; Vallianatou, T; Wadensten, H; Zhang, X | 1 |
| Hartman, K; Mielczarek, P; Silberring, J; Smoluch, M | 1 |
| Bruchas, MR; Cone, AL; Ndiokho, IB; Norris, AJ; Shaker, JR | 1 |
| Liu, X; Ma, M; Wang, K; Wang, R; Wang, Y; Wei, S; Zhang, X; Zhao, L; Zhou, J | 1 |
| Fujieda, S; Fukazawa, Y; Kuroda, K; Maegawa, A; Murata, K | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
40 review(s) available for enkephalin, leucine and dynorphins
| Article | Year |
|---|---|
Hippocampal opioid peptides and seizures.
Topics: Afferent Pathways; Amygdala; Animals; Dynorphins; Electric Stimulation; Endorphins; Enkephalins; Gene Expression Regulation; Kindling, Neurologic; Limbic System; Nerve Fibers; Receptors, Opioid; Seizures; Synaptic Transmission | 1992 |
Opioid receptors and their ligands: natural and unnatural.
Topics: Dynorphins; Endorphins; Enkephalins; Humans; Narcotics; Receptors, Opioid | 1991 |
Neuropeptide gene expression and neural activity: assessing a working hypothesis in nucleus caudalis and dorsal horn neurons expressing preproenkephalin and preprodynorphin.
Topics: Animals; Dynorphins; Enkephalins; Gene Expression Regulation; Nucleic Acid Hybridization; Protein Precursors; RNA, Messenger; Spinal Cord; Trigeminal Nuclei | 1990 |
Endogenous opioid peptides and farm animal reproduction.
Topics: Anestrus; Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalins; Female; Luteinizing Hormone; Menstrual Cycle; Receptors, Opioid; Reproduction; Sheep | 1989 |
[Possible role of opioid peptides in the control of energy homeostasis].
Topics: Animals; Diabetes Mellitus, Type 2; Digestive System; Dynorphins; Endorphins; Energy Metabolism; Enkephalins; Glucose; Homeostasis; Humans; Islets of Langerhans; Liver; Pancreas | 1985 |
Endorphins: what are they? How are they measured? What is their role in exercise?
Topics: Adrenocorticotropic Hormone; Animals; Dynorphins; Endorphins; Enkephalins; Follicle Stimulating Hormone; Growth Hormone; Hemodynamics; Humans; Luteinizing Hormone; Naloxone; Oxygen Consumption; Physical Exertion; Prolactin; Radioimmunoassay; Receptors, Opioid; Thyrotropin | 1985 |
Opioid biology: the next set of questions.
Topics: Cardiovascular Diseases; Dynorphins; Endocrine System Diseases; Endorphins; Enkephalins; Female; Humans; Male; Nervous System Diseases; Protein Processing, Post-Translational; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1985 |
Biochemistry of peptide-secreting neurons.
Topics: Animals; Biological Transport; Corpus Striatum; Dynorphins; Electric Stimulation; Endopeptidases; Endorphins; Enkephalins; Forecasting; Ganglia, Spinal; Neprilysin; Nerve Tissue Proteins; Neurons; Neurophysins; Oxytocin; Peptide Biosynthesis; Peptides; Pituitary Gland, Posterior; Receptors, Opioid; Somatostatin; Substantia Nigra; Tachykinins; Vasopressins | 1985 |
The endocrinology of the opioids.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; beta-Endorphin; Circadian Rhythm; Dynorphins; Endocrine Glands; Endorphins; Enkephalins; Female; Humans; Hypothalamo-Hypophyseal System; Islets of Langerhans; Melanocyte-Stimulating Hormones; Oxytocin; Pain; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Pregnancy; Rats; Receptors, Opioid; Shock; Stress, Physiological | 1985 |
Role of cholecystokinin and opioid peptides in control of food intake.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; beta-Endorphin; beta-Lipotropin; Brain; Ceruletide; Cholecystokinin; Digestive System Physiological Phenomena; Dynorphins; Eating; Endorphins; Enkephalins; Fasting; Food; Humans; Immunologic Techniques; Kinetics; Morphine; Nervous System; Neurons; Obesity; Peptide Fragments; Protein Precursors; Receptors, Cell Surface; Receptors, Cholecystokinin; Satiation; Sincalide; Species Specificity; Structure-Activity Relationship; Tissue Distribution | 1986 |
Functional response of multiple opioid systems to chronic arthritic pain in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arthritis; Arthritis, Experimental; Benzomorphans; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Morphine; Naloxone; Nociceptors; Pain; Pituitary Gland, Anterior; Protein Precursors; Pyrrolidines; Rats; Receptors, Opioid; Sensory Thresholds; Spinal Cord; Thalamus | 1986 |
Hypothalamic dynorphin and vasopressin mRNA expression in normal and Brattleboro rats.
Topics: Animals; Dynorphins; Enkephalins; Histocytochemistry; Hypothalamus; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Brattleboro; RNA, Messenger; Vasopressins | 1986 |
Anatomical and biochemical perspectives on opioid peptides.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; Genes; Neurons; Neurotransmitter Agents; Pro-Opiomelanocortin; Protein Precursors; Protein Processing, Post-Translational | 1986 |
[Discovery, anatomical mapping and biosynthesis of various families of endogenous opioid peptides].
Topics: Brain Chemistry; Dynorphins; Endorphins; Enkephalins; Humans | 1986 |
Localization of enkephalins and other endogenous opioids in the digestive tract.
Topics: Animals; Cats; Digestive System; Dynorphins; Embryonic and Fetal Development; Endorphins; Enkephalins; Guinea Pigs; Immunochemistry; Microscopy, Electron; Muscle, Smooth; Neurons; Phylogeny; Pro-Opiomelanocortin; Protein Precursors | 1987 |
Peripheral actions of opiates in canine gastrointestinal tract: actions on nerves and muscles.
Topics: Animals; Cell Membrane; Digestive System; Dogs; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gastrointestinal Motility; Histocytochemistry; Immunochemistry; Intestine, Small; Motilin; Muscles; Narcotics; Receptors, Opioid; Stomach | 1987 |
Opioids and opioid receptors in peripheral tissues.
Topics: Animals; Digestive System; Dynorphins; Endorphins; Enkephalins; Humans; Immunity; Peripheral Nerves; Receptors, Opioid; Stress, Physiological | 1987 |
Cytochemical studies of the neural circuitry underlying pain and pain control.
Topics: Animals; Dynorphins; Enkephalins; Pain; Spinal Cord | 1987 |
Endogenous opioid peptides and human reproduction.
Topics: Amino Acid Sequence; Animals; Dynorphins; Endorphins; Enkephalins; Humans; Neurosecretory Systems; Nociceptors; Placenta; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid; Reproduction | 1987 |
Localization and seizure-induced alterations of opioid peptides and CCK in the hippocampus.
Topics: Animals; Cholecystokinin; Dynorphins; Endorphins; Enkephalins; Hippocampus; Neuropeptides; Protein Precursors; RNA, Messenger; Seizures | 1988 |
Opioid receptor mechanisms in the rat hippocampus.
Topics: Animals; Dynorphins; Electrophysiology; Enkephalin, Leucine; gamma-Aminobutyric Acid; Hippocampus; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Central distribution of opioid peptides.
Topics: Animals; Basal Ganglia; beta-Endorphin; Central Nervous System; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; Neural Pathways; Neurons; Rats; Spinal Cord; Subcellular Fractions; Synapses; Tissue Distribution; Trigeminal Nucleus, Spinal | 1983 |
Biogenesis, release and inactivation of enkephalins and dynorphins.
Topics: Amino Acid Sequence; Animals; Brain; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Mice; Pain; Protein Precursors; Rats; Stress, Physiological | 1983 |
Biosynthesis and distribution of opioid peptides.
Topics: Adrenal Medulla; Adrenocorticotropic Hormone; Animals; beta-Endorphin; beta-Lipotropin; Brain; Dynorphins; Endorphins; Enkephalins; Gastric Mucosa; Humans; Ileum; Melanocyte-Stimulating Hormones; Pituitary Gland; Pituitary Hormones, Anterior; Pro-Opiomelanocortin; Protein Precursors | 1983 |
Multiple opiate receptors and their functional significance.
Topics: Animals; beta-Endorphin; Brain; Cyclazocine; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Morphine; Receptors, Opioid; Tissue Distribution | 1983 |
Putative peptide neurotransmitters: the opioid peptides.
Topics: Animals; Brain; Dynorphins; Endorphins; Enkephalins; Neurons; Peptide Fragments; Receptors, Opioid; Synaptic Transmission | 1983 |
Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.
Topics: Acetylcholine; Afferent Pathways; Analgesics; Animals; beta-Endorphin; Brain Stem; Dynorphins; Endorphins; Enkephalins; Medulla Oblongata; Models, Biological; Neural Pathways; Neurons; Neurotensin; Norepinephrine; Pain; Peptide Fragments; Periaqueductal Gray; Pituitary Hormones, Anterior; Pro-Opiomelanocortin; Protein Precursors; Spinal Cord; Stress, Physiological | 1984 |
Multiple opioid receptor systems in brain and spinal cord: Part I.
Topics: Animals; Autoradiography; Bacterial Outer Membrane Proteins; beta-Endorphin; Binding Sites; Binding, Competitive; Biological Assay; Brain Chemistry; Dynorphins; Endorphins; Enkephalins; Humans; In Vitro Techniques; Ligands; Magnesium; Naloxone; Narcotics; Porins; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Receptors, Virus; Spinal Cord; Structure-Activity Relationship | 1984 |
Opioid peptides in the pituitary: a hormone, a paracrine modulator and a peptide in search of a function.
Topics: Animals; Dynorphins; Enkephalins; In Situ Hybridization; Opioid Peptides; Oxytocin; Peptide Fragments; Pituitary Gland; Pro-Opiomelanocortin; Transcription, Genetic | 1994 |
Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens.
Topics: Adrenal Cortex Hormones; Animals; Corpus Striatum; Dopamine; Dynorphins; Enkephalins; Neuropeptides; Neurotensin; Nucleus Accumbens | 1994 |
Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dynorphins; Efferent Pathways; Enkephalins; Globus Pallidus; Neurons; Substantia Nigra | 1998 |
Endogenous dynorphins: possible role in peripheral tinnitus.
Topics: Cochlea; Dynorphins; Endorphins; Enkephalins; Humans; Olivary Nucleus; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Tinnitus | 1999 |
Opioid receptors and their ligands.
Topics: Amino Acid Sequence; Animals; Brain; Dynorphins; Enkephalins; Humans; Ligands; Molecular Sequence Data; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Protein Binding; Receptors, Opioid; Recombinant Fusion Proteins; Structure-Activity Relationship | 2004 |
Conformational analysis of opioid peptides in the solid states and the membrane environments by NMR spectroscopy.
Topics: beta-Endorphin; Dynorphins; Enkephalin, Leucine; Enkephalins; Lipid Bilayers; Magnetic Resonance Spectroscopy; Micelles; Opioid Peptides; Protein Conformation; Receptors, Opioid, kappa; Structure-Activity Relationship | 2004 |
Cholecystokinin antagonists a new way to improve the analgesia from old analgesics?
Topics: Analgesics; Animals; Cholecystokinin; Clinical Trials as Topic; Drug Tolerance; Dynorphins; Enkephalins; Humans; Narcotics; Pain; Time Factors | 2004 |
The role of endogenous opioids in the placebo effect in post-traumatic stress disorder.
Topics: Dynorphins; Endorphins; Enkephalins; Humans; Placebo Effect; Stress Disorders, Post-Traumatic; Stress, Psychological | 2004 |
The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.
Topics: Brain; Central Nervous System Stimulants; Cyclic AMP Response Element-Binding Protein; Dynorphins; Enkephalins; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mental Disorders; Models, Animal; Protein Precursors; Receptors, Opioid, kappa; Self Stimulation; Signal Transduction | 2012 |
κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.
Topics: Adaptation, Biological; Animals; Behavior, Addictive; Disease Models, Animal; Drug Discovery; Dynorphins; Enkephalins; Genetic Predisposition to Disease; Humans; Illicit Drugs; Narcotic Antagonists; Polymorphism, Genetic; Protein Precursors; Receptors, Opioid, kappa; Recurrence | 2012 |
[Development of physical dependence on nicotine and endogenous opioid system--participation of α7 nicotinic acetylcholine receptor].
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Brain; Dynorphins; Endorphins; Enkephalins; Humans; Hypothalamo-Hypophyseal System; Mice; Naloxone; Narcotic Antagonists; Nicotine; Nociception; Opioid Peptides; Pituitary-Adrenal System; Tobacco Use Disorder | 2014 |
Inhibitors of neuropeptide peptidases engaged in pain and drug dependence.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Enzyme Inhibitors; Humans; Neuropeptides; Pain; Peptide Hydrolases; Protease Inhibitors; Substance-Related Disorders | 2020 |
752 other study(ies) available for enkephalin, leucine and dynorphins
| Article | Year |
|---|---|
Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal neuropeptides.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; In Situ Hybridization; Male; Neuropeptides; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Vasopressin modulates cerebrovascular responses to opioids in newborn pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Arginine Vasopressin; Brain; Dynorphins; Endorphins; Enkephalins; Female; Male; Pyrrolidines; Receptors, Opioid; Swine; Vasoconstriction | 1992 |
Influence of opioids on CSF vasopressin concentration in newborn pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analysis of Variance; Animals; Animals, Newborn; beta-Endorphin; Cerebral Arteries; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Naloxone; Pyrrolidines; Swine; Vasopressins | 1992 |
Chronic stress elevates enkephalin expression in the rat paraventricular and supraoptic nuclei.
Topics: Adrenalectomy; Animals; Autoradiography; Dynorphins; Enkephalins; Female; Gene Expression; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains; Reference Values; Saline Solution, Hypertonic; Stress, Physiological; Sulfur Radioisotopes; Supraoptic Nucleus; Water-Electrolyte Balance | 1992 |
Peptides for calling? An immunohistochemical study of the avian n. intercollicularis.
Topics: Adrenocorticotropic Hormone; Animals; Birds; Columbidae; Dynorphins; Endorphins; Enkephalin, Leucine; Female; Immune Sera; Immunohistochemistry; Male; Mesencephalon; Species Specificity; Vocalization, Animal | 1992 |
The influence of opioids on local cerebral glucose utilization in the newborn pig.
Topics: Animals; Animals, Newborn; Autoradiography; Brain; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Glucose; Swine; Tissue Distribution | 1992 |
Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations.
Topics: Animals; Brain; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Radioimmunoassay; Stress, Physiological | 1992 |
PC12 rat pheochromocytoma cells synthesize dynorphin. Its secretion is modulated by nicotine and nerve growth factor.
Topics: Animals; Blotting, Northern; Cell Differentiation; Chromatography, Gel; Dynorphins; Enkephalins; Gene Expression; Hexamethonium; Hexamethonium Compounds; Molecular Weight; Nerve Growth Factors; Nicotine; PC12 Cells; Potassium Chloride; Protein Precursors; Rats; RNA, Messenger | 1992 |
Kappa opioid agonists inhibit transmitter release from guinea pig hippocampal mossy fiber synaptosomes.
Topics: Animals; Azocines; Calcium; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Male; Potassium; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptosomes | 1992 |
Lateral hypothalamic area neurotransmission and neuromodulation of the specific cardiac effects of insular cortex stimulation.
Topics: Animals; Cerebral Cortex; Cobalt; Dynorphins; Electric Stimulation; Electrocardiography; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Heart Rate; Hypothalamic Area, Lateral; Kynurenic Acid; Male; Neuropeptide Y; Rats; Rats, Inbred Strains; Synaptic Transmission | 1992 |
Modulation of peristalsis in the guinea-pig isolated small intestine by exogenous and endogenous opioids.
Topics: Algorithms; Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Narcotics; Peristalsis; Receptors, Opioid | 1992 |
Presence of a dynorphin-like peptide in a restricted subpopulation of catecholaminergic neurons in rat nucleus tractus solitarii.
Topics: Animals; Catecholamines; Dynorphins; Enkephalins; Fluorescent Antibody Technique; Male; Medulla Oblongata; Neurons; Rats; Rats, Sprague-Dawley | 1992 |
Characterization of dynorphin A-converting enzyme in human spinal cord. An endoprotease related to a distinct conversion pathway for the opioid heptadecapeptide?
Topics: Amino Acid Sequence; Chromatography, Gel; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Dynorphins; Electrophoresis, Polyacrylamide Gel; Enkephalins; Humans; Molecular Sequence Data; Peptide Fragments; Receptors, Opioid, delta; Spinal Cord; Substrate Specificity | 1992 |
Alterations in mRNA of enkephalin, dynorphin and thyrotropin releasing hormone during amygdala kindling: an in situ hybridization study.
Topics: Amygdala; Animals; Base Sequence; Dynorphins; Enkephalins; In Situ Hybridization; Kindling, Neurologic; Male; Molecular Sequence Data; Oligonucleotide Probes; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thyrotropin-Releasing Hormone | 1992 |
kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures.
Topics: Animals; Benzeneacetamides; Calcium; Cells, Cultured; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Mesencephalon; Narcotics; Potassium; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1992 |
Effects of intracerebroventricularly administered mu-, delta- and kappa-opioid agonists on locomotor activity of the guinea pig and the pharmacology of the locomotor response to U50,488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Hypnotics and Sedatives; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Motor Activity; Narcotics; Peptide Fragments; Piloerection; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
[Effect of opioid peptides on progesterone production by rat luteal cells in vitro].
Topics: Animals; beta-Endorphin; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Luteal Cells; Progesterone; Rats; Rats, Sprague-Dawley | 1992 |
[Endogenous opioid systems as biochemical basis of pain control].
Topics: Amino Acid Sequence; Dynorphins; Endorphins; Enkephalins; Humans; Molecular Sequence Data; Pain | 1992 |
Effect of mu-, kappa-, and delta-selective opioid agonists on thermoregulation in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Molecular Sequence Data; Morphinans; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.
Topics: Animals; Animals, Newborn; Capsaicin; Dynorphins; Enkephalins; Female; Foot Diseases; Gene Expression; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1992 |
Cocaine self-administration differentially alters mRNA expression of striatal peptides.
Topics: Animals; Autoradiography; Caudate Nucleus; Cocaine; Corpus Striatum; Deoxyadenine Nucleotides; Dynorphins; Enkephalins; Gene Expression; Male; Oligonucleotide Probes; Rats; Reference Values; RNA, Messenger; Self Administration; Substance P; Sulfur Radioisotopes | 1992 |
Identification of opioid receptors on gastric muscle cells by selective receptor protection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Stomach | 1991 |
Stereoselective effect of morphine on antinociception and endogenous opioid peptide levels in plasma but not cerebrospinal fluid of dogs.
Topics: Animals; Behavior, Animal; beta-Endorphin; Dogs; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Subcutaneous; Morphine; Nociceptors; Pain Measurement; Stereoisomerism; Tritium | 1991 |
Opioid inhibition of nicotine-induced 45Ca2(+)-uptake into cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Benzomorphans; Calcium; Cattle; Cells, Cultured; Chromaffin System; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Nicotine; Oligopeptides | 1991 |
Opioids in cerebrospinal fluid in hypotensive newborn pigs.
Topics: Animals; Animals, Newborn; beta-Endorphin; Cerebral Arteries; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hemorrhage; Hypotension; Muscle, Smooth, Vascular; Radioimmunoassay; Radioligand Assay; Reference Values; Swine; Vasodilation | 1991 |
Characterization of opioid-sensitive neurons in the anteroventral third ventricle region of polydipsic inbred mice in vitro.
Topics: Angiotensin II; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Drinking Behavior; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypothalamus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Neurons; Peptide Fragments; Species Specificity | 1991 |
Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb.
Topics: Adenylyl Cyclases; Alkaloids; Animals; beta-Endorphin; Calcium; Cholera Toxin; Cyclic AMP; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enzyme Activation; Guanosine Triphosphate; Intracellular Fluid; Kinetics; Male; Naloxone; Olfactory Bulb; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Opioid; Staurosporine; Stimulation, Chemical | 1991 |
Effects of receptor-selective opioids on operant behavior in morphine-treated and untreated rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Food; Infusions, Intravenous; Injections, Intraventricular; Male; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Nonspecific tolerance in ileal circular muscle-myenteric plexus preparations from morphine-pretreated guinea pigs.
Topics: 2-Chloroadenosine; Animals; Clonidine; Drug Tolerance; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Myenteric Plexus; Receptors, Opioid | 1991 |
Effect of opioid peptides on circular muscle of canine duodenum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Muscles; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid | 1991 |
Sequence similarity between opioid peptide precursors and DNA-binding proteins.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cattle; DNA; DNA-Binding Proteins; Dynorphins; Enkephalins; Humans; Molecular Sequence Data; Protein Precursors; Sequence Homology, Nucleic Acid; Transcription Factors | 1991 |
Evidence for enkephalin- and endorphin-immunoreactive cells in the anterior pituitary of the axolotl Ambystoma mexicanum.
Topics: Ambystoma mexicanum; Animals; Antibodies; beta-Endorphin; Cross Reactions; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fluorescent Antibody Technique; Immunohistochemistry; Nerve Fibers; Pituitary Gland, Anterior | 1991 |
Inhibition by opioids of phagocytosis in peritoneal macrophages.
Topics: Animals; beta-Endorphin; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Erythrocytes; Macrophages; Mice; Morphine; Naloxone; Peritoneal Cavity; Phagocytosis; Sheep | 1991 |
Naltrexone-sensitizing effects of centrally administered morphine and opioid peptides.
Topics: Animals; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
mu-receptor mediates elevated glucose and corticosterone after third ventricle injection of opioid peptides.
Topics: Animals; beta-Endorphin; Blood Glucose; Cerebral Ventricles; Corticosterone; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fatty Acids, Nonesterified; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration | 1991 |
Isoforms of a dynorphin B converting enzyme isolated by column electrophoresis in agarose suspension.
Topics: Animals; Cattle; Chromatography, Gel; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Dynorphins; Electrophoresis, Agar Gel; Endorphins; Enkephalin, Leucine; Hydroxymercuribenzoates; Isoelectric Point; Isoenzymes; Kinetics; Molecular Weight; Spinal Cord | 1991 |
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes | 1991 |
Effects of dexfenfluramine and opioid peptides, alone or in combination, on food intake and brain serotonin turnover in rats.
Topics: Animals; beta-Endorphin; Brain; Drug Interactions; Dynorphins; Eating; Endorphins; Enkephalin, Leucine; Female; Fenfluramine; Naltrexone; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1991 |
Opioids can produce a concentration-dependent naloxone-reversible enhancement of inhibition of evoked enkephalin release.
Topics: Analgesics; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Naloxone; Narcotics; Parasympatholytics; Sufentanil; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Effect of opioid peptides on electrically evoked acetylcholine release from Torpedo electromotor neurons.
Topics: Acclimatization; Acetylcholine; Animals; Dynorphins; Electric Organ; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; In Vitro Techniques; Motor Neurons; Naloxone; Seasons; Torpedo | 1991 |
Enkephalin hydrolysis by human serum biotinidase.
Topics: Amidohydrolases; Amino Acid Sequence; Biotinidase; Dynorphins; Electrophoresis, Polyacrylamide Gel; Endorphins; Enkephalins; Humans; Hydrolysis; Kinetics; Lysine; Molecular Sequence Data; Substrate Specificity; Vitamins | 1991 |
Human brain leucyl aminopeptidase: isolation, characterization and specificity against some neuropeptides.
Topics: Amino Acid Sequence; Angiotensin II; Arginine Vasopressin; Cations, Divalent; Cerebral Cortex; Chromatography, Ion Exchange; Dynorphins; Enkephalin, Leucine; Humans; Hydrolysis; Leucyl Aminopeptidase; Molecular Sequence Data; Neuropeptides; Sincalide; Somatostatin; Substrate Specificity | 1991 |
Activation of mu opioid receptors in the pre-optic-anterior hypothalamus releases prolactin in the conscious male rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anterior Hypothalamic Nucleus; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Preoptic Area; Prolactin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Expression of preprodynorphin in human small cell lung carcinoma cell lines.
Topics: Blotting, Northern; Carcinoma, Small Cell; Dynorphins; Enkephalins; Humans; Protein Precursors; RNA, Messenger; Tumor Cells, Cultured | 1991 |
Opioids at low concentration decrease openings of K+ channels in sensory ganglion neurons.
Topics: Action Potentials; Animals; Dynorphins; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Narcotic Antagonists; Narcotics; Neurons, Afferent; Osmolar Concentration; Potassium Channels | 1991 |
Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation.
Topics: Animals; Blotting, Northern; Body Weight; Diabetes Mellitus, Experimental; Dynorphins; Eating; Enkephalins; Fasting; Food Deprivation; Hypothalamus; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Neuropeptide Y; RNA, Messenger; Somatostatin; Species Specificity; Thyrotropin-Releasing Hormone | 1991 |
A glutamate antagonist blocks perforant path stimulation-induced reduction of dynorphin peptide and prodynorphin mRNA levels in rat hippocampus.
Topics: Animals; Dipeptides; Dynorphins; Enkephalins; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Histocytochemistry; Male; Neural Pathways; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Tremor | 1991 |
Sex differences in the basal firing rate and the responsiveness to opioid peptides of rat hippocampal neurons.
Topics: Action Potentials; Animals; Dynorphins; Enkephalin, Leucine; Female; Hippocampus; Male; Orchiectomy; Ovariectomy; Rats; Rats, Inbred Strains; Sex Characteristics | 1991 |
Studies of specificity and inhibition of human cerebrospinal fluid dynorphin converting enzyme.
Topics: Amino Acid Sequence; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Humans; Hydroxylamines; Molecular Sequence Data; Peptides; Protease Inhibitors; Substrate Specificity | 1991 |
Localization of chemical messengers in magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei: an immunohistochemical study using experimental manipulations.
Topics: Animals; Cholecystokinin; Colchicine; Corticotropin-Releasing Hormone; Dogs; Dynorphins; Enkephalins; Fluorescent Antibody Technique; Galanin; Hypophysectomy; Immunohistochemistry; Oxytocin; Paraventricular Hypothalamic Nucleus; Peptide PHI; Peptides; Rats; Rats, Brattleboro; Rats, Inbred Strains; Supraoptic Nucleus; Thyrotropin-Releasing Hormone; Tyrosine 3-Monooxygenase; Vasopressins | 1990 |
Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis.
Topics: Animals; Corpus Striatum; Dopamine; Dynorphins; Enkephalins; Histocytochemistry; Immunohistochemistry; Neurons; Nucleic Acid Hybridization; RNA, Messenger; Substance P | 1991 |
Co-expression of neuropeptides in the cat's striatum: an immunohistochemical study of substance P, dynorphin B and enkephalin.
Topics: Animals; Cats; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression Regulation; Immunoenzyme Techniques; Neurons; Staining and Labeling; Substance P | 1990 |
Dopamine dependent decrease in enkephalin and substance P levels in basal ganglia regions of postmortem parkinsonian brains.
Topics: Aged; Aged, 80 and over; Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Dopamine; Dynorphins; Enkephalins; Frontal Lobe; Humans; Male; Middle Aged; Parkinson Disease; Putamen; Radioimmunoassay; Rats; Serotonin; Substance P | 1991 |
Atrial natriuretic polypeptide secretion via selective activation of kappa-opioid receptor: role of dynorphin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzomorphans; Cells, Cultured; Diuretics; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart; Heart Atria; Kinetics; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Levodopa replacement therapy alters enzyme activities in striatum and neuropeptide content in striatal output regions of 6-hydroxydopamine lesioned rats.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Drug Administration Schedule; Dynorphins; Enkephalins; Functional Laterality; Globus Pallidus; Glutamate Decarboxylase; Levodopa; Male; Oxidopamine; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1991 |
Differential modulation of striatonigral dynorphin and enkephalin by dopamine receptor subtypes.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Corpus Striatum; Dynorphins; Enkephalins; Ergolines; Hydroxydopamines; Male; Oxidopamine; Quinpirole; Rats; Rats, Inbred F344; Receptors, Dopamine; Substantia Nigra | 1990 |
Adrenal dynorphin A and Leu-enkephalin levels in normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR).
Topics: Adrenal Glands; Age Factors; Animals; Dynorphins; Enkephalin, Leucine; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY | 1990 |
Conversion of the dynorphins to Leu-enkephalin in human spinal cord.
Topics: Amino Acid Sequence; Dynorphins; Enkephalin, Leucine; Enkephalins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Molecular Sequence Data; Molecular Weight; Protein Precursors; Serine Endopeptidases; Serine Proteinase Inhibitors; Spinal Cord | 1990 |
Dynorphin prolongs the action potential duration of mouse sensory ganglion neurons by decreasing a K+ conductance whereas the specific kappa opioid, U-50,488H does so by increasing a Ca2+ conductance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dynorphins; Electric Conductivity; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; In Vitro Techniques; Mice; Neurons; Potassium Channels; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Intracerebroventricular analgesia enhanced by intrathecal (IT) dynorphin A(1-17) antibody.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Physostigmine; Pyrrolidines | 1990 |
Hemodynamic responses of conscious rats following intrathecal injections of prodynorphin-derived opioids: independence of action of intrathecal arginine vasopressin.
Topics: Animals; Arginine Vasopressin; beta-Endorphin; Blood Pressure; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Heart Rate; Hemodynamics; Injections, Spinal; Male; Narcotics; Norepinephrine; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains | 1990 |
Formation of [Leu5]enkephalin from dynorphin A(1-8) by rat central nervous tissue in vitro.
Topics: Animals; Brain; Central Nervous System; Dynorphins; Endorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Peptide Fragments; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord | 1990 |
Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig.
Topics: Animals; Autoradiography; Dynorphins; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Microelectrodes; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity; Synapses | 1990 |
The occurrence and receptor specificity of endogenous opioid peptides within the pancreas and liver of the rat. Comparison with brain.
Topics: Animals; beta-Endorphin; Brain; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Immunohistochemistry; Liver; Male; Pancreas; Radioimmunoassay; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Perforant path stimulation differentially alters prodynorphin mRNA and proenkephalin mRNA levels in the entorhinal cortex-hippocampal region.
Topics: Animals; Cerebral Cortex; Dynorphins; Electric Stimulation; Enkephalins; Gene Expression Regulation; Hippocampus; Male; Nucleic Acid Hybridization; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger | 1990 |
Immunohistochemistry of opioid peptides in the guinea pig endocrine pancreas.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Immunohistochemistry; Islets of Langerhans | 1990 |
Behavioral changes induced by stressful situations: effects of enkephalins, dynorphin, and their interactions.
Topics: Animals; Behavior, Animal; Drug Interactions; Dynorphins; Endorphins; Enkephalins; Male; Mice; Peptide Fragments; Physical Exertion; Stress, Physiological; Swimming | 1990 |
Dynorphin prolongs the action potential of mouse sensory ganglion neurons by decreasing a potassium conductance whereas another specific kappa opioid does so by increasing a calcium conductance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ganglia, Spinal; In Vitro Techniques; Mice; Narcotics; Neural Conduction; Neurons; Potassium; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Effects of preferential delta and kappa opioid receptor agonists on the intake of hypotonic saline.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drinking; Dynorphins; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Food Preferences; Hypotonic Solutions; Injections, Intraventricular; Male; Oligopeptides; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Taste | 1990 |
Characterization of opioid receptors modulating the function of capsaicin-sensitive neurons in guinea-pig atria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Benzomorphans; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Male; Morphine; Neurons; Pyrrolidines; Receptors, Opioid; Reserpine | 1990 |
An inhibitor of endopeptidase-24.15 blocks the degradation of intraventricularly administered dynorphins.
Topics: Animals; Brain; Captopril; Cerebral Ventricles; Choroid Plexus; Dynorphins; Enkephalin, Leucine; Kinetics; Leucine; Male; Metalloendopeptidases; Neprilysin; Oligopeptides; Peptide Fragments; Peptidyl-Dipeptidase A; Perfusion; Rats; Rats, Inbred Strains | 1990 |
Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Neurons, Afferent; Oligopeptides; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Reserpine | 1990 |
Spinal dynorphin A (1-17): possible mediator of antianalgesic action.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Nociceptors; Physostigmine; Pyrrolidines; Spinal Cord | 1990 |
Kappa opioid receptors stimulate phosphoinositide turnover in rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Dynorphins; Enkephalins; Ethylketocyclazocine; Male; Phosphatidylinositols; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Regulatory role of enteric mu and kappa opioid receptors in the release of acetylcholine and norepinephrine from guinea pig ileum.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; Male; Muscle, Smooth; Norepinephrine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Cholecystokinin octapeptide antagonized opioid analgesia mediated by mu- and kappa- but not delta-receptors in the spinal cord of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Proglumide; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Spinal Cord | 1990 |
Opioid agonists, prostaglandin E1 and clonidine modulate non-adrenergic, non-cholinergic transmission in the mammalian heart.
Topics: Adrenergic beta-Antagonists; Alprostadil; Animals; Atrial Function; Capsaicin; Clonidine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Heart Atria; Imidazoles; In Vitro Techniques; Morphine; Myocardial Contraction; Nerve Fibers | 1990 |
The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study.
Topics: Analgesics; Animals; Dialysis; Dopamine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Magnesium; Male; Nucleus Accumbens; Peptide Fragments; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin | 1990 |
Influence of nigrostriatal dopaminergic tone on the biosynthesis of dynorphin and enkephalin in rat striatum.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Dopamine; Dynorphins; Enkephalins; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred F344; Reference Values; RNA, Messenger; Substantia Nigra | 1990 |
Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Autoradiography; Cerebral Cortex; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Humans; Iodocyanopindolol; Ketanserin; Male; Middle Aged; Oxotremorine; Paroxetine; Pindolol; Piperidines; Pirenzepine; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Opioid; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1990 |
Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Densitometry; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Veratridine | 1990 |
Phorbol ester suppression of opioid analgesia in rats.
Topics: Analgesia; Animals; Calcium; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Peptide Fragments; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Spinal Cord; Tetradecanoylphorbol Acetate | 1990 |
Characterization of the opioid receptor type mediating inhibition of rat gastric somatostatin secretion.
Topics: Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Somatostatin | 1990 |
Prostanoids modulate opioid cerebrovascular responses in newborn pigs.
Topics: Administration, Topical; Animals; Animals, Newborn; Arachnoid; Arterioles; beta-Endorphin; Blood Gas Analysis; Cerebrovascular Circulation; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hydrogen-Ion Concentration; Indomethacin; Male; Pia Mater; Prostaglandins; Swine; Vasodilation | 1990 |
Trophic effects of enkephalin, beta-endorphine and dynorphine on ventral spinal cord in culture.
Topics: Animals; Axons; beta-Endorphin; Cells, Cultured; Dynorphins; Enkephalins; Rats; Rats, Inbred Strains; Spinal Cord | 1990 |
Expression of vasopressin and opiates but not of oxytocin genes studied by in situ hybridization in embryonic rat brain primary cultures.
Topics: Animals; Brain; Cells, Cultured; Dynorphins; Endorphins; Enkephalins; Gene Expression; Nucleic Acid Hybridization; Oxytocin; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Vasopressins | 1990 |
Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid | 1990 |
Differentiation of acupuncture and nonacupuncture points by difference of associated opioids in the spinal cord in production of analgesia by acupuncture and nonacupuncture point stimulation, and relations between sodium and those opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acupuncture Analgesia; Acupuncture Points; Analgesics; Animals; Benzomorphans; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride; Spinal Cord | 1990 |
Effects of intracerebroventricular injection of dynorphin, leumorphin and alpha neo-endorphin on operant feeding in pigs.
Topics: Animals; Appetitive Behavior; Brain; Conditioning, Operant; Dynorphins; Endorphins; Enkephalins; Feeding Behavior; Female; Injections, Intraventricular; Male; Motivation; Naloxone; Peptide Fragments; Protein Precursors; Receptors, Opioid; Swine | 1990 |
Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration.
Topics: Action Potentials; Animals; beta-Endorphin; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Protein Precursors; Receptors, Opioid; Sodium; Time Factors | 1985 |
Partial purification of two distinct enkephalin-degrading aminopeptidases from human cerebrospinal fluid.
Topics: Aminopeptidases; Angiotensins; Anti-Bacterial Agents; Chromatography; Dynorphins; Enkephalin, Leucine; Humans; Oligopeptides; Peptide Fragments; Peptides; Protease Inhibitors; Secretin; Substance P | 1985 |
Immunohistochemistry of beta-neoendorphin and dynorphin in the endocrine pancreas of rat and man.
Topics: Adrenocorticotropic Hormone; Animals; Dynorphins; Enkephalins; Frozen Sections; Humans; Immune Sera; Immunoenzyme Techniques; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Species Specificity; Staining and Labeling | 1985 |
Immunoreactive dynorphin B in sacral primary afferent fibers of the cat.
Topics: Animals; Axons; Cats; Colchicine; Dynorphins; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; Histocytochemistry; Neurons, Afferent; Radioimmunoassay; Sacrum; Spinal Cord; Staining and Labeling | 1986 |
Inhibition of shock-elicited ultrasonic vocalization by opioid peptides in the rat: a psychotropic effect.
Topics: Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalins; Fear; Injections, Intraventricular; Male; Psychotropic Drugs; Rats; Rats, Inbred Strains; Substance P; Vocalization, Animal | 1986 |
Gilles de la Tourette's syndrome. A postmortem neuropathological and immunohistochemical study.
Topics: Acetylcholinesterase; Adult; Brain; Dynorphins; Enkephalins; Globus Pallidus; Humans; Immunoenzyme Techniques; Male; Substance P; Substantia Nigra; Tourette Syndrome | 1986 |
Striato-nigral dynorphin and substance P pathways in the rat. I. Biochemical and immunohistochemical studies.
Topics: Animals; Corpus Striatum; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glutamate Decarboxylase; Male; Motor Activity; Neural Pathways; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1986 |
Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Dynorphins; Enkephalin, Leucine; Ganglia, Spinal; Ion Channels; Mice; Neurons; Time Factors | 1986 |
Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.
Topics: Animals; Autoradiography; Brain Mapping; Dopamine; Dynorphins; Enkephalins; Gene Expression Regulation; Male; Mesencephalon; Rats; RNA, Messenger; Substance P; Tyrosine 3-Monooxygenase | 1986 |
[Establishment of a map of neurons in the brain of Eisenia fetida (Annelida, Oligochaeta) containing substances immunologically specific to vertebrate peptides].
Topics: Animals; Brain; Corticotropin-Releasing Hormone; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Growth Hormone-Releasing Hormone; Histocytochemistry; Immunologic Tests; Neurons; Neuropeptides; Oligochaeta; Serotonin; Sincalide; Substance P | 1987 |
The effects of endorphins on mucous glycoprotein secretion from feline airways in vitro.
Topics: alpha-Endorphin; Animals; beta-Endorphin; Cats; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Endorphin; Glycoproteins; Morphine; Mucus; Naloxone; Organ Culture Techniques; Secretory Rate; Trachea | 1987 |
Dynorphin and related opioid peptides enhance tumoricidal activity mediated by murine peritoneal macrophages.
Topics: Animals; Cytotoxicity, Immunologic; Dynorphins; Enkephalin, Leucine; Interferons; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Naloxone; Neoplasms, Experimental; Peptide Fragments; Peritoneal Cavity; Receptors, Opioid | 1987 |
Mu-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways.
Topics: Animals; Autonomic Nervous System; Bronchi; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Morphine; Muscle Contraction; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Substance P; Trachea | 1987 |
Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures.
Topics: Action Potentials; Animals; Barium; Calcium; Cesium; Chlorides; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fetus; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Neurons, Afferent; Organ Culture Techniques; Potassium; Tetraethylammonium; Tetraethylammonium Compounds | 1988 |
Prodynorphin gene expression in spinal cord is enhanced after traumatic injury in the rat.
Topics: Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Male; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA; RNA, Complementary; RNA, Messenger; Spinal Cord Injuries | 1988 |
Projection pathways, co-existence of peptides and synaptic organization of nerve fibers in the inferior mesenteric ganglion of the guinea-pig.
Topics: Animals; Bombesin; Cholecystokinin; Dynorphins; Enkephalins; Ganglia, Sympathetic; Guinea Pigs; Immunohistochemistry; Male; Microscopy, Electron; Nerve Fibers; Neuropeptide Y; Peptides; Substance P; Synapses; Vasoactive Intestinal Peptide | 1988 |
Regulated expression of the prodynorphin gene in the R2C Leydig tumor cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Northern; Cyclic AMP; Dynorphins; Enkephalin, Leucine; Enkephalins; Gene Expression Regulation; Leydig Cell Tumor; Male; Mice; Nucleic Acid Hybridization; Pro-Opiomelanocortin; Protein Precursors; Rats; RNA, Messenger; Testicular Neoplasms; Testis; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study.
Topics: Animals; Axonal Transport; Corpus Striatum; DNA; Dynorphins; Enkephalins; Globus Pallidus; Histocytochemistry; Male; Neurons; Neuropeptides; Nucleic Acid Hybridization; Oligonucleotide Probes; Rats; Rats, Inbred Strains; Receptors, Opioid; RNA, Messenger; Substance P; Substantia Nigra; Transcription, Genetic | 1988 |
Biochemical mapping of cholecystokinin-, substance P-, [Met]enkephalin-, [Leu]enkephalin- and dynorphin A (1-8)-like immunoreactivities in the human cerebral cortex.
Topics: Aged; Aged, 80 and over; Cerebral Cortex; Cholecystokinin; Dynorphins; Enkephalins; Female; Humans; Male; Peptide Fragments; Radioimmunoassay; Substance P | 1988 |
Steady-state levels of pro-dynorphin-related end-products from the brain of the amphibian, Xenopus laevis.
Topics: Animals; Brain; Dynorphins; Endorphins; Enkephalins; Protein Precursors; Xenopus laevis | 1989 |
Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task.
Topics: Aging; Animals; Blotting, Northern; Cognition; Dynorphins; Enkephalins; Hippocampus; Learning; Protein Precursors; Rats; RNA, Messenger | 1989 |
Ultrastructural analysis of dynorphin B-immunoreactive cells and terminals in the superficial dorsal horn of the deafferented spinal cord of the rat.
Topics: Afferent Pathways; Animals; Axons; Dynorphins; Enkephalins; Laminectomy; Male; Microscopy, Electron; Photomicrography; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Nerve Roots | 1989 |
Measurement and chromatographic characterization of prodynorphin-derived peptides in the guinea-pig ileum.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Ileum; Peptide Fragments; Protein Precursors; Radioimmunoassay | 1989 |
Effect of endogenous opioid peptides on TRH release from rat stomach in vitro.
Topics: Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Gastric Mucosa; In Vitro Techniques; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Stomach; Thyrotropin-Releasing Hormone | 1989 |
Computer analysis of the effect of beta-endorphin and dynorphin and related compounds on opioid binding to mouse brain membrane.
Topics: Animals; beta-Endorphin; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Mice; Models, Neurological; Receptors, Opioid | 1989 |
Differential modulation by [D-Pen2, D-Pen5]enkephalin and dynorphin A-(1-17) of the inhibitory bladder motility effects of selected mu agonists in vivo.
Topics: Analgesics; Animals; Drug Synergism; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Morphine; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Urinary Bladder | 1989 |
A novel bovine spinal cord endoprotease with high specificity for dynorphin B.
Topics: Amino Acid Sequence; Animals; Cations, Divalent; Cattle; Chelating Agents; Chromatography, High Pressure Liquid; Dynorphins; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Endorphins; Enkephalin, Leucine; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; Protease Inhibitors; Spinal Cord; Substrate Specificity; Sulfhydryl Reagents | 1989 |
Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord.
Topics: Animals; Dynorphins; Enkephalins; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; RNA, Messenger; Spinal Cord | 1989 |
Presynaptic auto- and allelo-receptor regulation of hypothalamic opioid peptide release.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Narcotic Antagonists; Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Induction of the gene encoding pro-dynorphin by experimentally induced arthritis enhances staining for dynorphin in the spinal cord of rats.
Topics: Animals; Arthritis; Dynorphins; Enkephalins; Gene Expression Regulation; Immunohistochemistry; Male; Pain; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Spinal Cord | 1989 |
Prodynorphin peptide distribution in the forebrain of the Syrian hamster and rat: a comparative study with antisera against dynorphin A, dynorphin B, and the C-terminus of the prodynorphin precursor molecule.
Topics: Animals; Brain Chemistry; Colchicine; Cricetinae; Dynorphins; Endorphins; Enkephalins; Immune Sera; Immunoenzyme Techniques; Male; Mesocricetus; Peptide Fragments; Perfusion; Protein Precursors; Rats; Rats, Inbred Strains; Species Specificity | 1989 |
Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla.
Topics: Action Potentials; Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Male; Medulla Oblongata; Peptide Fragments; Periaqueductal Gray; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
Opioid-like activity in the cerebrospinal fluid of pain patients treated by electroacupuncture.
Topics: beta-Endorphin; Chromatography, High Pressure Liquid; Chronic Disease; Dynorphins; Electroacupuncture; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Pain; Pain Management; Radioimmunoassay | 1989 |
Facilitatory effects of opioids on the discharges of visceral nociceptors.
Topics: Animals; Bradykinin; Dinoprostone; Dogs; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epididymis; Evoked Potentials; Male; Morphine; Naloxone; Nociceptors; Testis | 1989 |
Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.
Topics: Action Potentials; Animals; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Myenteric Plexus; Naloxone; Sufentanil | 1989 |
[High and low frequency electroacupuncture analgesia are mediated by different types of opioid receptors at spinal level: a cross tolerance study].
Topics: Acupuncture Analgesia; Analgesics; Animals; Dynorphins; Electroacupuncture; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Peptide Fragments; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1989 |
Solution syntheses of two enkephalin-containing peptides, peptide E and dynorphin(1-24), using Nin-(2,4,6-triisopropylphenylsulfonyl)tryptophan.
Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry; Dynorphins; Enkephalins; Indicators and Reagents; Molecular Sequence Data; Peptides; Solutions; Tryptophan | 1989 |
The comparative distribution of enkephalin, dynorphin and substance P in the human globus pallidus and basal forebrain.
Topics: Diencephalon; Dynorphins; Enkephalins; Globus Pallidus; Humans; Immunoenzyme Techniques; Species Specificity; Substance P; Telencephalon | 1985 |
Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Binding Sites; Brain; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Levallorphan; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1985 |
Antinociception and paralysis induced by intrathecal dynorphin A.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Motor Activity; Naloxone; Nociceptors; Paralysis; Rats; Rats, Inbred Strains | 1985 |
Opioid peptides increase calcium uptake by synaptosomes from brain regions.
Topics: Animals; beta-Endorphin; Brain; Calcium; Corpus Striatum; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Frontal Lobe; Hippocampus; In Vitro Techniques; Peptide Fragments; Rats; Synaptosomes | 1985 |
Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat.
Topics: Animals; Cyclazocine; Dynorphins; Electrophysiology; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; gamma-Aminobutyric Acid; Hippocampus; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Methionine and leucine enkephalin in rat neurohypophysis: different responses to osmotic stimuli and T2 toxin.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Osmosis; Oxytocin; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Sesquiterpenes; T-2 Toxin; Vasopressins; Water Deprivation | 1985 |
Possible interactions between dynorphin and dopaminergic systems in rat basal ganglia and substantia nigra.
Topics: Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Globus Pallidus; Haloperidol; Male; Putamen; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
[Stress and the endogenous opioid system. II. Stress, stress models and endogenous opioid peptides].
Topics: Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalins; General Adaptation Syndrome; Humans; Peptides; Receptors, Opioid; Stress, Physiological | 1985 |
Proenkephalin and prodynorphin related neuropeptides in the cochlea.
Topics: Animals; Cochlea; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Guinea Pigs; Hair Cells, Auditory; Nerve Tissue Proteins; Protein Precursors | 1985 |
Treatment of stroke with opiate antagonists--effects of exogenous antagonists and dynorphin 1-13.
Topics: Acute Disease; Animals; Brain Ischemia; Cats; Dynorphins; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments | 1985 |
Opiate receptor-mediated chemotaxis of human monocytes.
Topics: beta-Endorphin; Chemotaxis; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Humans; In Vitro Techniques; Monocytes; Peptide Fragments; Receptors, Opioid | 1985 |
Localization and quantitation of proenkephalin-derived neuropeptides in the rat hippocampus.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hippocampus; Limbic System; Male; Neural Pathways; Radioimmunoassay; Rats; Rats, Inbred Strains | 1985 |
Dynorphinergic pathways of Leu-enkephalin production in the rat brain.
Topics: Animals; Corpus Striatum; Dynorphins; Enkephalin, Leucine; Enkephalins; Male; Neural Pathways; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Separate populations of opioid containing neurons in the guinea-pig intestine.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fluorescent Antibody Technique; Guinea Pigs; Male; Myenteric Plexus; Peptide Fragments; Submucous Plexus; Vasoactive Intestinal Peptide | 1985 |
Development of hypothalamic opioid neurons: a combined immunocytochemical and [3H]thymidine autoradiographic study.
Topics: Adrenocorticotropic Hormone; Animals; Autoradiography; Dynorphins; Enkephalin, Leucine; Female; Hypothalamus; Immunoenzyme Techniques; Male; Rats; Rats, Inbred Strains; Thymidine | 1985 |
Effects of traumatic injury on dynorphin immunoreactivity in spinal cord.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Male; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Injuries; Subcellular Fractions; Synaptosomes | 1985 |
[Protective action of endogenous opioid-like peptides of different origins in duodenal ulcer in rats].
Topics: Animals; Anti-Ulcer Agents; Cysteamine; Drug Evaluation, Preclinical; Duodenal Ulcer; Dynorphins; Enkephalins; Male; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Inbred Strains | 1985 |
A general procedure for analysis of proenkephalin B derived opioid peptides.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Humans; Hypothalamus; Molecular Weight; Pituitary Gland; Protein Precursors | 1985 |
Stimulation by leumorphin of prolactin secretion from the pituitary in rats.
Topics: Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Male; Naloxone; Pituitary Gland, Anterior; Prolactin; Protein Precursors; Rats; Swine; Thyrotropin-Releasing Hormone | 1985 |
Isolation and characterization of an endogenous C-terminal fragment of the alpha-neo-endorphin/dynorphin precursor from bovine caudate nucleus.
Topics: Animals; Cattle; Caudate Nucleus; Dynorphins; Endorphins; Enkephalins; Protein Precursors; Rabbits; Radioimmunoassay | 1985 |
Generalization tests with intraventricularly applied pro-enkephalin B-derived peptides in rats trained to discriminate the opioid kappa receptor agonist ethylketocyclazocine.
Topics: Animals; beta-Endorphin; Cyclazocine; Discrimination Learning; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Generalization, Stimulus; Injections, Intraventricular; Male; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Colocalization of dynorphin-A(1-17) and dynorphin-A(1-8) within some perikarya of rat duodenum: immunohistochemical evidence for the presence of two separate dynorphinergic systems.
Topics: Animals; Brain Chemistry; Duodenum; Dynorphins; Enkephalin, Leucine; Fluorescent Antibody Technique; Male; Nerve Fibers; Neurons; Peptide Fragments; Rats; Rats, Inbred Strains; Tissue Distribution | 1985 |
Neuropeptide processing by single-step cleavage: conversion of leumorphin (dynorphin B-29) to dynorphin B.
Topics: Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Dynorphins; Endopeptidases; Endorphins; Enkephalins; Iodine Radioisotopes; Kinetics; Protein Precursors; Rats | 1985 |
On the origin of Leu-enkephalin and Met-enkephalin in the rat neurohypophysis.
Topics: Animals; Arginine Vasopressin; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus, Middle; Male; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Sodium Glutamate | 1985 |
Hemorrhagic shock and the central vasopressin and opioid peptide system of rats.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Brain Chemistry; Dynorphins; Enkephalin, Leucine; Heart Rate; Hematocrit; Male; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains; Shock, Hemorrhagic; Tissue Distribution | 1985 |
Non-dopaminergic mechanisms in the turning behavior evoked by intranigral opiates.
Topics: Animals; Dynorphins; Enkephalins; Hydroxydopamines; Male; Medial Forebrain Bundle; Morphine; Movement; Naltrexone; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Dynorphin levels in parkinsonian patients: Leu5-enkephalin production from either proenkephalin A or prodynorphin in human brain.
Topics: Aged; Brain; Brain Chemistry; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Parkinson Disease; Protein Precursors | 1985 |
Release of immunoreactive Met-enkephalin from the spinal cord by intraventricular beta-endorphin but not morphine in anesthetized rats.
Topics: Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Peptide Fragments; Rats; Rats, Inbred Strains; Spinal Cord | 1985 |
Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary.
Topics: Animals; beta-Endorphin; Dehydration; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Food Deprivation; Hypothalamus; Male; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Inbred Strains | 1985 |
Selective presence of opiate receptors on intestinal circular muscle cells.
Topics: Acetylcholine; Animals; Atropine; Benzomorphans; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Humans; Jejunum; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Proglumide; Receptors, Opioid; Sincalide | 1985 |
Effects of opioid agonists and antagonists on oxytocin and vasopressin release in vitro.
Topics: Animals; Arginine Vasopressin; Benzomorphans; beta-Endorphin; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains | 1985 |
Prodynorphin opioid peptides in small somatosensory primary afferents of guinea pig.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; Guinea Pigs; Male; Neurons, Afferent; Neurotransmitter Agents; Peripheral Nerves; Protein Precursors; Somatosensory Cortex; Trigeminal Ganglion | 1985 |
Endopeptidase in human cerebrospinal fluid which cleaves proenkephalin B opioid peptides at consecutive basic amino acids.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Humans; Hydrolysis; Protein Precursors; Radioimmunoassay; Serine Endopeptidases; Serine Proteinase Inhibitors | 1985 |
Conversion of dynorphin-(1-9) to [Leu5]enkephalin by the mouse vas deferens in vitro.
Topics: Animals; Benzomorphans; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Muscle, Smooth; Narcotic Antagonists; Peptide Fragments; Vas Deferens | 1985 |
Time of origin of opioid peptide-containing neurons in the rat hypothalamus.
Topics: Adrenocorticotropic Hormone; Animals; Autoradiography; Dynorphins; Endorphins; Enkephalin, Leucine; Female; Histocytochemistry; Hypothalamus; Immunologic Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Thymidine; Time Factors | 1985 |
Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. I. Behavioral characterization.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Administration Schedule; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Microinjections; Motor Activity; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Tegmentum Mesencephali | 1985 |
Enkephalin-degrading activity in arthropode hemolymphe.
Topics: Amino Acids; Aminopeptidases; Animals; Astacoidea; Dynorphins; Enkephalins; Hemolymph; Horseshoe Crabs; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Peptide Hydrolases; Puromycin | 1985 |
Effects of opioid peptides containing the sequence of Met5-enkephalin or Leu5-enkephalin on nicotine-induced secretion from bovine adrenal chromaffin cells.
Topics: Adenosine Triphosphate; Adrenal Medulla; Amino Acid Sequence; Animals; Bacitracin; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guinea Pigs; Leucine; Nicotine; Norepinephrine; Peptide Fragments; Phenanthrolines; Rabbits; Receptors, Opioid; Thiorphan; Tiopronin | 1986 |
Opioid binding in a rat neurohypophysial fraction enriched in oxytocin and vasopressin nerve endings.
Topics: Animals; Arginine Vasopressin; Binding Sites; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats | 1985 |
Steady state levels of pro-dynorphin-related end products in the striatum and substantia nigra of the adult rhesus monkey.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Corpus Striatum; Dynorphins; Endorphins; Enkephalins; Female; Macaca mulatta; Peptide Fragments; Protein Precursors; Radioimmunoassay; Substantia Nigra | 1985 |
Antinociceptive profiles of opioid peptide agonists in a rat tooth pulp stimulation procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dental Pulp; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Pain; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains | 1985 |
Presynaptic inhibitory opioid delta- and kappa-receptors in a branch of the rabbit ileocolic artery.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Female; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Naloxone; Norepinephrine; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vasoconstriction | 1985 |
Actions of opiate agonists, naloxone, and paraben preservatives in the rat lung circulation.
Topics: Angiotensin II; Animals; Dynorphins; Enkephalin, Leucine; Hypoxia; Male; Morphine; Naloxone; Potassium Chloride; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Characterization of opioid receptor subtypes in solution.
Topics: Animals; Brain; Cations; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Guanylyl Imidodiphosphate; Iodoacetamide; Kinetics; Magnesium; Naloxone; Rats; Receptors, Opioid; Sodium; Solutions | 1986 |
Differential effect of stimulation strength in mouse vas deferens on inhibition of neuroeffector transmission by receptor type selective opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cyclazocine; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Morphine Derivatives; Muscle, Smooth; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Synaptic Transmission | 1986 |
Different effects of dynorphin A on in vitro guinea pig hippocampal CA3 pyramidal cells with various degrees of paired-pulse facilitation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 1986 |
Dynorphin- and enkephalin-like immunoreactivity is altered in limbic-basal ganglia regions of rat brain after repeated electroconvulsive shock.
Topics: Animals; Basal Ganglia; Brain Chemistry; Dynorphins; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalins; Hippocampus; Immunologic Techniques; Male; Radioimmunoassay; Rats; Rats, Inbred F344; Time Factors; Tissue Distribution | 1986 |
The stimulation of food intake by selective agonists of mu, kappa and delta opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Dynorphins; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1986 |
Opioid-induced feeding: localization of sensitive brain sites.
Topics: Animals; beta-Endorphin; Brain Mapping; Corpus Striatum; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Hypothalamus; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Stimulation, Chemical | 1986 |
Enkephalin-containing polypeptides in human cerebrospinal fluid.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Hydrogen-Ion Concentration; Molecular Weight; Peptides; Protein Precursors; Radioimmunoassay | 1986 |
Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit.
Topics: Animals; Benzomorphans; Clonidine; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hippocampus; Morphine; Norepinephrine; Rabbits; Receptors, Opioid | 1986 |
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Presynaptic opioid receptors modulating acetylcholine release in the hippocampus of the rabbit.
Topics: Acetylcholine; Animals; Benzomorphans; Choline; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Naloxone; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Peptides derived from prodynorphin are decreased in basal ganglia of Huntington's disease brains.
Topics: Basal Ganglia; Caudate Nucleus; Dynorphins; Endorphins; Enkephalins; Globus Pallidus; Humans; Huntington Disease; Protein Precursors; Putamen; Substantia Nigra | 1986 |
Enkephalin but not morphine modulates the motor activity in the frog spinal cord in vitro.
Topics: Animals; Dynorphins; Electric Stimulation; Electrophysiology; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Histocytochemistry; In Vitro Techniques; Morphine; Motor Activity; Naloxone; Rana catesbeiana; Reflex; Spinal Cord | 1986 |
Conversion of leumorphin (dynorphin B-29) to dynorphin B and dynorphin B-14 by thiol protease activity.
Topics: Adrenocorticotropic Hormone; Cysteine Endopeptidases; Dynorphins; Endopeptidases; Endorphins; Enkephalins; Hydrogen-Ion Concentration; Peptides; Protease Inhibitors; Protein Precursors; Temperature | 1986 |
RIA/chromatographic evidence for novel opioid peptide(s) in Squilla mantis ganglia.
Topics: Animals; beta-Endorphin; Brain; Chromatography, Gel; Decapoda; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia; Molecular Weight; Radioimmunoassay; Radioligand Assay; Rats; Receptors, Opioid | 1986 |
Changes in the immunoreactivities of an opioid peptide leumorphin in the hypothalamus and anterior pituitary during the estrous cycle of the rat and their relation to sexual behavior.
Topics: Animals; Antigen-Antibody Reactions; Dynorphins; Enkephalins; Estrus; Female; Hypothalamus; Pituitary Gland, Anterior; Protein Precursors; Rats; Rats, Inbred Strains; Sexual Behavior, Animal | 1986 |
Effects of opioid peptides on immunoreactive corticotropin-releasing factor release from the rat hypothalamus in vitro.
Topics: Animals; Corticotropin-Releasing Hormone; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dynorphins; Endorphins; Enkephalins; Hypothalamus; In Vitro Techniques; Male; Naloxone; Radioimmunoassay; Rats; Secretory Rate | 1986 |
High-performance liquid chromatography and diode-array detection for the identification of peptides containing aromatic amino acids in studies of endorphin-degrading activity in human cerebrospinal fluid.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Dynorphins; Endopeptidases; Endorphins; Enkephalin, Leucine; Humans; Neprilysin; Peptide Fragments; Peptides; Spectrophotometry, Ultraviolet | 1986 |
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hypercapnia; Hypoxia; Peptide Fragments; Receptors, Opioid | 1986 |
Centrally-administered opioid selective agonists inhibit drinking in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Drinking Behavior; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid | 1986 |
Coexistence of enkephalin and dynorphin immunoreactivities in neurons in the dorsal gray commissure of the sixth lumbar and first sacral spinal cord segments in rat.
Topics: Animals; Dynorphins; Enkephalins; Fluorescent Antibody Technique; Histocytochemistry; Lumbosacral Region; Male; Neurons; Rats; Spinal Cord | 1986 |
Kainic acid alters the metabolism of Met5-enkephalin and the level of dynorphin A in the rat hippocampus.
Topics: Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Hippocampus; Histocytochemistry; Immunochemistry; Kainic Acid; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred F344; RNA, Messenger; Seizures | 1986 |
Immunohistochemical evidence for extrinsic and intrinsic opioid systems in the guinea pig superior cervical ganglion.
Topics: Animals; Cross Reactions; Dynorphins; Endorphins; Enkephalin, Leucine; Female; Ganglia, Sympathetic; Guinea Pigs; Immune Sera; Immunoenzyme Techniques; Protein Precursors | 1986 |
Characterization of opioid peptides in the rat stomach.
Topics: Animals; Chromatography; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Radioimmunoassay; Radioligand Assay; Rats; Rats, Inbred Strains; Stomach; Trypsin | 1986 |
Response of rat pituitary anterior lobe prodynorphin products to changes in gonadal steroid environment.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Female; Gonadal Steroid Hormones; Male; Orchiectomy; Ovariectomy; Pituitary Gland, Anterior; Protein Precursors; Rats; Testosterone | 1986 |
Evidence for the presence of adrenocorticotropic and opiate-like hormones in the brains of two sea snakes, Hydrophis cyanocinctus and Lapemis hardwickii.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; beta-Endorphin; Biological Assay; Brain; Brain Chemistry; Corticosterone; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Female; Lipolysis; Male; Melanocyte-Stimulating Hormones; Snakes; Tissue Extracts | 1986 |
[Effects of opiate and opioid peptides administered intrathecally on the pain threshold and micturition reflex in rats].
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Injections, Spinal; Morphine; Pain; Rats; Rats, Inbred Strains; Reflex; Sensory Thresholds; Urination | 1986 |
Degradation of dynorphin-(1-13) and dynorphin-(1-17) by the neuroblastoma cell membrane. Evidence for the involvement of a cysteine protease.
Topics: Amino Acids; Captopril; Cell Line; Cysteine Endopeptidases; Dynorphins; Endopeptidases; Enkephalin, Leucine; Ethylmaleimide; Neuroblastoma; Peptide Fragments | 1986 |
Are opioid peptides co-localized with vasopressin or oxytocin in the neural lobe of the rat?
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Histological Techniques; Neurophysins; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Vasopressins | 1986 |
Opioids act centrally to modulate stress-induced decrease in luteinizing hormone in the rat.
Topics: Animals; beta-Endorphin; Corticotropin-Releasing Hormone; Dynorphins; Electroshock; Endorphins; Enkephalins; Immunologic Techniques; Luteinizing Hormone; Male; Rats; Receptors, Opioid; Stress, Physiological | 1986 |
Behavioral effects of centrally administered dynorphin and [D-ala2-D-leu] enkephalin (DADLE) in rats.
Topics: Acoustic Stimulation; Animals; Avoidance Learning; Cerebral Ventricles; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hot Temperature; Injections, Intraventricular; Male; Motor Activity; Pain; Rats; Rats, Inbred F344; Reflex, Startle | 1986 |
Amygdaloid kindling increases enkephalin-like immunoreactivity but decreases dynorphin-A-like immunoreactivity in rat hippocampus.
Topics: Amygdala; Animals; Brain Stem; Corpus Striatum; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Frontal Lobe; Hippocampus; Histocytochemistry; Hypothalamus; Kindling, Neurologic; Male; Radioimmunoassay; Rats; Rats, Inbred F344 | 1986 |
Synaptosomal membrane-bound form of endopeptidase-24.15 generates Leu-enkephalin from dynorphin1-8, alpha- and beta-neoendorphin, and Met-enkephalin from Met-enkephalin-Arg6-Gly7-Leu8.
Topics: Animals; beta-Endorphin; Brain; Chromatography, High Pressure Liquid; Dynorphins; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Metalloendopeptidases; Peptide Fragments; Protease Inhibitors; Protein Precursors; Rats; Rats, Inbred Strains; Synaptic Membranes; Synaptosomes; Trypsin | 1987 |
The stimulation of glycogenolysis in isolated hepatocytes by opioid peptides.
Topics: Animals; Calcium; Cyclic AMP; Dynorphins; Enkephalin, Leucine; Glycogen Synthase; In Vitro Techniques; Liver; Liver Glycogen; Male; Phosphorylase a; Protein Kinases; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1986 |
Peptides as receptor selectivity modulators of opiate pharmacophores.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Indicators and Reagents; Kinetics; Oligopeptides; Receptors, Opioid; Structure-Activity Relationship | 1986 |
Binding characteristics of [3H]opioid ligands to active opioid binding sites solubilized from rat brain membranes by glycodeoxycholate and NaCl: the recovery of binding activity by dilution.
Topics: Animals; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Glycodeoxycholic Acid; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride; Solutions | 1987 |
Distribution of opiate receptor subtypes and enkephalin and dynorphin immunoreactivity in the hippocampus of squirrel, guinea pig, rat, and hamster.
Topics: Animals; Autoradiography; Cricetinae; Dynorphins; Endorphins; Enkephalins; Female; Guinea Pigs; Hippocampus; Histocytochemistry; Immunochemistry; Male; Mesocricetus; Rats; Receptors, Opioid; Sciuridae | 1987 |
Brain endo-oligopeptidase A, a putative enkephalin converting enzyme.
Topics: Animals; Bradykinin; Brain; Cattle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Metalloendopeptidases; Neurotensin; Peptide Fragments; Rats; Substrate Specificity; Sulfhydryl Reagents | 1987 |
[Frequency as the cardinal determinant for electroacupuncture analgesia to be reversed by opioid antagonists].
Topics: Acupuncture Therapy; Animals; beta-Endorphin; Dynorphins; Electric Stimulation Therapy; Endorphins; Enkephalins; Naloxone; Naltrexone; Pain; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Effects of beta-chlornaltrexamine on food intake, body weight and opioid-induced feeding.
Topics: Animals; Body Weight; Dynorphins; Eating; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Preproenkephalin B-derived opioid peptides in human phaeochromocytomas.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Cells, Cultured; Dynorphins; Endorphins; Enkephalins; Epinephrine; Female; Glucagon; Humans; Male; Middle Aged; Nicotine; Norepinephrine; Pheochromocytoma; Protein Precursors; Radioimmunoassay | 1987 |
Current views on endogenous ligands for opiate recognition sites.
Topics: Animals; Central Nervous System; Dynorphins; Endorphins; Enkephalins; Humans; Ligands; Peripheral Nerves; Psychopharmacology; Receptors, Opioid; Tissue Distribution | 1986 |
On the presence of opioid receptors in guinea-pig ventricular tissue.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Heart; Hydroxydopamines; In Vitro Techniques; Myocardium; Naloxone; Narcotics; Norepinephrine; Oxidopamine; Peptide Fragments; Protease Inhibitors; Receptors, Opioid; Sympathetic Nervous System | 1987 |
Antagonism of mu-opioid receptor-mediated inhibitions of nociceptive neurones by U50488H and dynorphin A1-13 in the rat dorsal horn.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Naloxone; Neural Inhibition; Nociceptors; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1987 |
Activation of periaqueductal grey pools of beta-endorphin by analgetic electrical stimulation in freely moving rats.
Topics: Animals; beta-Endorphin; Dynorphins; Electric Stimulation Therapy; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Locomotion; Male; Periaqueductal Gray; Prolactin; Rats; Rats, Inbred Strains; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1987 |
Purified opioid mu-receptor is of a different molecular size than delta- and kappa-receptors.
Topics: Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
A re-examination of the localization of immunoreactive dynorphin(1-8), [Leu]enkephalin and [Met]enkephalin in the rat neurohypophysis.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Histocytochemistry; Immunoenzyme Techniques; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats; Rats, Brattleboro; Rats, Inbred Strains | 1987 |
[Involvement of dynorphin in the antinociception induced by intrathecal injection of neurotensin in the rat].
Topics: Analgesia; Animals; Dynorphins; Enkephalins; Female; Immunoglobulin G; Injections, Spinal; Naloxone; Neurotensin; Protease Inhibitors; Rats | 1987 |
Bilateral intranigral microinjection of morphine and opioid peptides produces antinociception in rats.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Microinjections; Morphine; Naloxone; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time; Substantia Nigra | 1987 |
Fast atom bombardment mass spectrometry analysis of opioid peptides.
Topics: Amino Acid Sequence; Dynorphins; Electrochemistry; Endorphins; Enkephalins; Mass Spectrometry | 1987 |
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Benzazepines; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Methionine; Enkephalins; Ergolines; Female; Gene Expression Regulation; Hippocampus; Hydroxydopamines; Male; Motor Activity; Neuropeptides; Oxidopamine; Peptide Fragments; Protein Precursors; Quinpirole; Rats; Rats, Inbred Strains; RNA, Messenger; Substantia Nigra; Tachykinins | 1987 |
Purification of a kappa-opioid receptor subtype from frog brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Chromatography, Gel; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Membranes; Molecular Weight; Naloxone; Peptide Fragments; Pyrrolidines; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa; Solubility | 1987 |
Coexistence of putative neuroactive substances in lateral olivocochlear neurons of rat and guinea pig.
Topics: Animals; Auditory Pathways; Axons; Choline O-Acetyltransferase; Cochlear Nerve; Dynorphins; Enkephalins; Fluorescent Antibody Technique; Neurons; Neurotransmitter Agents; Olivary Nucleus; Rats; Rats, Inbred Strains | 1987 |
Lithium and haloperidol differentially alter the dynorphin A (1-8) and enkephalin levels in the neurointermediate lobe of rat pituitary.
Topics: Animals; Dynorphins; Enkephalins; Haloperidol; Lithium; Male; Peptide Fragments; Pituitary Gland; Rats; Rats, Inbred F344 | 1987 |
Chromatographic characterization of dynorphin and [Leu5]enkephalin immunoreactivity in guinea pig and rat testis.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Male; Radioimmunoassay; Rats; Species Specificity; Testis | 1987 |
Endogenous opioids may mediate secondary damage after experimental brain injury.
Topics: Animals; Azocines; Blood Flow Velocity; Blood Pressure; Brain; Brain Injuries; Cats; Cerebrovascular Circulation; Dopamine; Dynorphins; Electroencephalography; Endorphins; Enkephalin, Leucine; Female; Intracranial Pressure; Isomerism; Male; Narcotic Antagonists | 1987 |
Synaptosomal free [Ca2+] is reduced by clonidine and dynorphin A-(1-13) and increased by idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Calcium; Clonidine; Dioxanes; Dioxins; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; In Vitro Techniques; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Synaptosomes | 1987 |
Mutual antagonism of kappa-opiate and alpha 2-adrenoceptor agonist effects on intrasynaptosomal free [Ca2+]i.
Topics: Aminoquinolines; Animals; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fluorescent Dyes; Idazoxan; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes | 1988 |
Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the cat.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain Injuries; Cats; Dynorphins; Enkephalin, Leucine; Osmolar Concentration; Radioimmunoassay; Tissue Distribution | 1987 |
Mu-, delta-, kappa- and epsilon-opioid receptor modulation of the hypothalamic-pituitary-adrenocortical (HPA) axis: subchronic tolerance studies of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Functional opioid receptor sites in human placentas.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gonadotropin-Releasing Hormone; Humans; Kinetics; Placenta; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thyrotropin-Releasing Hormone | 1988 |
Calmodulin content in rabbit reticulocyte and the influence of opioid peptides on calmodulin activity in its membrane.
Topics: Animals; beta-Endorphin; Calmodulin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Erythrocyte Membrane; Peptide Fragments; Rabbits; Reticulocytes | 1986 |
Bridge peptide is a cleavage product of pro-dynorphin processing in the rat anterior pituitary.
Topics: Animals; Dynorphins; Enkephalins; Male; Molecular Weight; Pituitary Gland, Anterior; Protein Precursors; Protein Processing, Post-Translational; Rats; Rats, Inbred Strains | 1986 |
Immunohistochemical evidence for subpopulations of dynorphinergic neurons.
Topics: Animals; Brain; Dynorphins; Enkephalins; Immunohistochemistry; Male; Neurons; Rats; Rats, Inbred Strains | 1986 |
Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia.
Topics: Animals; Basal Ganglia; Corpus Striatum; Dopamine; Dynorphins; Enkephalins; Genes; Hydroxydopamines; Oxidopamine; Protein Precursors; Rats; Rats, Inbred Strains; Transcription, Genetic | 1986 |
Dynorphin A (1-13): in vivo opioid antagonist actions and non-opioid anticonvulsant effects in the rat flurothyl test.
Topics: Animals; Anticonvulsants; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Flurothyl; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Seizures | 1986 |
Autoradiographic localization of supraspinal kappa-opioid receptors with [125I-Tyr1, D-Pro10]dynorphin A-(1-11).
Topics: Animals; Autoradiography; Brain; Cerebellum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Iodine Radioisotopes; Kinetics; Male; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Reference Values; Species Specificity | 1988 |
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
Topics: Animals; Autoradiography; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Membranes; Tomography, Emission-Computed | 1988 |
Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydrazines; Morphine; Peptide Fragments; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin | 1987 |
Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GABA Antagonists; Hippocampus; Interneurons; Naloxone; Oligopeptides; Rats; Receptors, Opioid | 1988 |
Dynorphin1-17 reduces the inhibitory actions of mu- and delta-selective opioid agonists in cortical neurons of the rat in vivo.
Topics: Animals; Cerebral Cortex; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Neural Inhibition; Neurons; Rats; Rats, Inbred Strains | 1988 |
Morphine-like discriminative stimulus effects of opioid peptides: possible modulatory role of D-Ala2-D-Leu5-enkephalin (DADL) and dynorphin A (1-13).
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Peptide Fragments; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Vasopressin, oxytocin, dynorphin, enkephalin and corticotrophin-releasing factor mRNA stimulation in the rat.
Topics: Animals; Corticotropin-Releasing Hormone; Dynorphins; Endorphins; Enkephalins; Hypothalamus; Male; Oxytocin; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains; RNA, Messenger; Supraoptic Nucleus; Vasopressins | 1987 |
Differential sensitivity of opioid-induced feeding to naloxone and naloxonazine.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Eating; Electroshock; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains | 1988 |
Immunocytochemical identification of long ascending, peptidergic lumbar spinal neurons terminating in either the medial or lateral thalamus in the rat.
Topics: Animals; Dynorphins; Enkephalins; Fluorescent Antibody Technique; Male; Neurons; Neuropeptides; Rats; Rats, Inbred Strains; Spinal Cord; Thalamus; Vasoactive Intestinal Peptide | 1988 |
Xenografts of mouse hippocampal tissue. Exchange of laminar and neuropeptide specific nerve connections with the host rat brain.
Topics: Age Factors; Animals; Cholecystokinin; Cholinergic Fibers; Dynorphins; Enkephalins; Graft Survival; Hippocampus; Immunohistochemistry; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred Strains; Transplantation, Heterologous | 1988 |
Characterization of opioid receptors on isolated canine gallbladder smooth muscle cells.
Topics: Animals; Benzomorphans; Dogs; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gallbladder; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Receptors, Opioid | 1988 |
Co-localization of proenkephalin- and prodynorphin-derived opioid peptides in laminae IV/V spinal neurons revealed in arthritic rats.
Topics: Animals; Arthritis, Rheumatoid; Dynorphins; Endorphins; Enkephalins; Male; Oligopeptides; Protein Precursors; Rats; Rats, Inbred Strains; Spinal Cord | 1988 |
CNS blockade of acoustic stress-induced gastric motor inhibition by kappa-opiate agonists in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Adrenocorticotropic Hormone; Analgesics; Animals; Cyclazocine; Dogs; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gastrointestinal Motility; Hydrocortisone; Pyrrolidines; Stress, Physiological | 1988 |
Cerebrospinal fluid activity of dynorphin-converting enzyme at term pregnancy.
Topics: Cesarean Section; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Enkephalins; Female; Humans; Luteal Phase; Pregnancy; Protein Precursors; Radioimmunoassay; Serine Endopeptidases | 1988 |
The effect of opiates upon prostatic carcinoma cell growth.
Topics: beta-Endorphin; Cell Division; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Male; Morphine; Naloxone; Narcotics; Prostatic Neoplasms; Receptors, Opioid; Tumor Cells, Cultured | 1988 |
Lithium increases dynorphin A(1-8) and prodynorphin mRNA levels in the basal ganglia of rats.
Topics: Animals; Basal Ganglia; Chlorides; Corpus Striatum; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Gene Expression Regulation; Genes; Haloperidol; Immunoenzyme Techniques; Lithium; Lithium Carbonate; Lithium Chloride; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Transcription, Genetic | 1988 |
Seizures induce dramatic and distinctly different changes in enkephalin, dynorphin, and CCK immunoreactivities in mouse hippocampal mossy fibers.
Topics: Animals; Cholecystokinin; Dynorphins; Enkephalins; Hippocampus; Immunochemistry; Kainic Acid; Mice; Nerve Fibers; Seizures | 1988 |
Central mu, delta- and kappa-opioid influences on intestinal water and electrolyte transport in dogs.
Topics: Animals; Body Water; Cerebral Ventricles; Cholera Toxin; Dogs; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Intestinal Absorption; Potassium; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sodium; Vagotomy | 1988 |
Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization.
Topics: Animals; DNA; Dynorphins; Enkephalin, Methionine; Enkephalins; Hyperalgesia; Hyperesthesia; Male; Nucleic Acid Hybridization; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1988 |
Antinociceptive action of intracerebroventricularly administered dynorphin and other opioid peptides in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Cold Temperature; Drug Interactions; Dynorphins; Enkephalins; Injections, Intraventricular; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1988 |
Dynorphin A [1-17] induces "reward" in rats in the place conditioning paradigm.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Rats; Rats, Inbred Strains; Reward | 1988 |
Effects of morphine and opioid peptides on plasma levels of atrial natriuretic peptide.
Topics: Animals; Atrial Natriuretic Factor; beta-Endorphin; Brain; Dynorphins; Endorphins; Enkephalin, Leucine; Epinephrine; Injections, Intraventricular; Male; Morphine; Norepinephrine; Rats; Rats, Inbred Strains | 1988 |
Enterochromaffin (EC-) cells of the mammalian gastro-entero-pancreatic (GEP) endocrine system: cellular source of pro-dynorphin-derived peptides.
Topics: Adrenal Medulla; Animals; Cattle; Chromaffin System; Digestive System; Dogs; Dynorphins; Endorphins; Enkephalins; Enterochromaffin Cells; Guinea Pigs; Humans; Immunohistochemistry; Pancreas; Pituitary Gland; Pro-Opiomelanocortin; Protein Precursors | 1988 |
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Hindlimb; Injections, Spinal; Male; Motor Activity; Nociceptors; Paralysis; Peptide Fragments; Rats; Rats, Inbred Strains; Spinal Cord | 1988 |
Direct dependence studies in rats with agents selective for different types of opioid receptor.
Topics: Analgesics; Animals; Behavior, Animal; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders | 1988 |
Opiate binding in calf thalamic membranes: a selective mu 1 binding assay.
Topics: Animals; Cattle; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus | 1988 |
Enkephalin is liberated from metorphamide and dynorphin A1-8 by endo-oligopeptidase A, but not by metalloendopeptidase EC 3.4.24.15.
Topics: Chemical Precipitation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dynorphins; Enkephalin, Methionine; Enkephalins; Metalloendopeptidases; Peptide Fragments | 1988 |
Peripheral sympatho-inhibitory cardiovascular effects of opioid peptides in anaesthetized rabbits.
Topics: Animals; Decerebrate State; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hemodynamics; Levallorphan; Male; Naloxone; Norepinephrine; Pentobarbital; Quaternary Ammonium Compounds; Rabbits; Sympathetic Nervous System | 1988 |
Effects of intrahypothalamic administration of opioid peptides selective for mu-, kappa, and delta-receptors on different schedules of water intake in the rat.
Topics: Animals; Drinking Behavior; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Saline Solution, Hypertonic; Time Factors | 1988 |
Distribution of opioid peptides in the preoptic region: immunohistochemical evidence for a steroid-sensitive enkephalin sexual dimorphism.
Topics: Animals; Animals, Newborn; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Female; Immunohistochemistry; Male; Ovariectomy; Peptides; Preoptic Area; Rats; Rats, Inbred Strains; Sex Characteristics; Steroids | 1988 |
Further studies on opioids and hibernation: delta opioid receptor ligand selectively induced hibernation in summer-active ground squirrels.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hibernation; Male; Morphine; Peptides; Proteins; Receptors, Opioid; Receptors, Opioid, delta; Reference Values; Sciuridae; Seasons; Structure-Activity Relationship | 1988 |
Differential expression of preproenkephalin and preprodynorphin mRNAs in striatal neurons: high levels of preproenkephalin expression depend on cerebral cortical afferents.
Topics: Animals; Blotting, Northern; Cerebral Cortex; Corpus Striatum; DNA; Dynorphins; Enkephalins; Male; Neurons; Neurons, Afferent; Nucleic Acid Hybridization; Protein Precursors; Rats; RNA, Messenger | 1988 |
Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes.
Topics: Animals; Aspartic Acid; Deoxyglucose; Dynorphins; Enkephalins; Glutamates; Glutamic Acid; Hippocampus; Male; Microscopy, Electron; Protein Precursors; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
Putative neurotransmitters in the rat cochlea at several ages.
Topics: Acetylcholine; Aging; Animals; Chromatography, High Pressure Liquid; Cochlea; Dynorphins; Enkephalins; Neurotransmitter Agents; Radioimmunoassay; Rats; Rats, Inbred F344; Reference Values | 1988 |
Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats.
Topics: Animals; Cats; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Narcotic Antagonists; Narcotics; Peptide Fragments; Stomach; Vagus Nerve | 1988 |
Regulation of human natural cytotoxicity by enkephalins and selective opiate agonists.
Topics: Adult; Cell Division; Cytotoxicity, Immunologic; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Humans; Killer Cells, Natural; Lymphocytes; Naloxone; Oligopeptides; Receptors, Opioid; T-Lymphocytes | 1988 |
Multiple opioid peptides and the modulation of pain: immunohistochemical analysis of dynorphin and enkephalin in the trigeminal nucleus caudalis and spinal cord of the cat.
Topics: Animals; Cats; Dynorphins; Enkephalins; Immunohistochemistry; Nerve Endings; Pain; Spinal Cord; Trigeminal Nucleus, Spinal | 1985 |
Neurologic deficits and neuronal injury in rats resulting from nonopioid actions of the delta opioid receptor antagonist ICI 174864.
Topics: Animals; Drug Tolerance; Dynorphins; Enkephalin, Leucine; Male; Narcotic Antagonists; Neurons; Paralysis; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1988 |
Biotransformation of neuropeptides.
Topics: beta-Endorphin; Cholecystokinin; Dynorphins; Endorphins; Enkephalins; Gonadotropin-Releasing Hormone; Nerve Tissue Proteins; Neurotensin; Oxytocin; Somatostatin; Substance P; Thyrotropin-Releasing Hormone; Vasopressins | 1984 |
Immunoreactive dynorphin in pituitary and brain.
Topics: Animals; Brain; Brain Mapping; Cattle; Dynorphins; Endorphins; Enkephalins; Immunoassay; Pituitary Gland; Rats; Spinal Cord; Swine | 1980 |
Possible regulatory role of dynorphin on morphine- and beta-endorphin-induced analgesia.
Topics: Analgesics; Animals; beta-Endorphin; Drug Interactions; Drug Tolerance; Dynorphins; Endorphins; Enkephalins; Humans; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Substance Withdrawal Syndrome | 1981 |
The preference of putative pro-enkephalins for different types of opiate receptors.
Topics: Animals; Benzomorphans; Brain; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Morphine; Protein Precursors; Rats; Receptors, Opioid; Vas Deferens | 1981 |
MIF-I suppresses deprivation-induced fluid consumption in rats.
Topics: Animals; Drinking; Dynorphins; Endorphins; Enkephalins; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1980 |
Effects of neuroleptic drugs on endogenous opioid peptides in the rat.
Topics: Animals; Antipsychotic Agents; beta-Endorphin; Brain; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Haloperidol; Pituitary Gland; Rats; Receptors, Dopamine; Receptors, Opioid; Synaptic Transmission | 1981 |
Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Ligands; Morphine Derivatives; Myenteric Plexus; Naloxone; Peptide Fragments; Receptors, Opioid | 1982 |
Opioid peptides in human plasma: evidence for multiple forms.
Topics: Adult; Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalins; Humans; Male; Molecular Weight; Physical Exertion; Radioimmunoassay; Trypsin | 1982 |
Dynorphin and vasopressin: common localization in magnocellular neurons.
Topics: Animals; Arginine Vasopressin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Hypothalamus; Immunologic Techniques; Male; Rats | 1982 |
Specific opiate receptors on isolated mammalian gastric smooth muscle cells.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalins; Gastric Mucosa; Guinea Pigs; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Neurotransmitter Agents; Receptors, Opioid | 1982 |
Dynorphin-related opioid peptides in the neurointermediate pituitary of rats are not alpha-N-acetylated.
Topics: Acetylation; Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Immunosorbent Techniques; Male; Molecular Weight; Peptide Fragments; Pituitary Gland; Rats; Rats, Inbred Strains | 1982 |
Studies on the structural prerequisites for the activation of the beta-endorphin receptor on the rat vas deferens.
Topics: Animals; beta-Endorphin; Drug Interactions; Dynorphins; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Male; Muscle, Smooth; Narcotics; Rats; Receptors, Opioid; Vas Deferens | 1982 |
Opioid peptides have found their roots.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Chemical Phenomena; Chemistry; Dynorphins; Endorphins; Enkephalins; Protein Precursors; Swine | 1982 |
Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Endorphin; Cattle; Cloning, Molecular; DNA; DNA Restriction Enzymes; DNA, Recombinant; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Hypothalamus; Protein Precursors; RNA, Messenger; Swine | 1982 |
Dynorphin and dynorphin are ligands for the kappa-subtype of opiate receptor.
Topics: Amino Acid Sequence; Animals; Biological Assay; Brain; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ligands; Mice; Peptide Fragments; Rabbits; Radioligand Assay; Rats; Receptors, Opioid; Structure-Activity Relationship | 1982 |
Dynorphin in bovine adrenal medulla. I. Detection in glandular and cellular extracts and secretion from isolated chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; Antibody Specificity; Cattle; Chemical Phenomena; Chemistry; Dynorphins; Endorphins; Enkephalin, Leucine; Nicotine; Peptide Fragments; Potassium Chloride; Radioimmunoassay | 1982 |
Recent studies on dynorphin and enkephalin precursor fragments in central nervous system.
Topics: Animals; Brain; Dynorphins; Endorphins; Enkephalins; Immunochemistry; Peptide Fragments; Rats | 1982 |
Activation of K-opiate sites by dynorphin in the myenteric plexus.
Topics: Animals; Cyclazocine; Drug Tolerance; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa | 1982 |
Stimulation of prolactin secretion in the rat by alpha-neo-endorphin, beta-neo-endorphin and dynorphin.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalins; Gonadotropin-Releasing Hormone; Injections, Intraventricular; Male; Naloxone; Pituitary Gland; Prolactin; Protein Precursors; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1982 |
In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Injections, Spinal; Male; Naloxone; Pain; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1982 |
Potency of three opiate antagonists to reverse the inhibitory activity of dynorphin, enkephalins and opioid-like alkaloids on the guinea pig ileum.
Topics: Animals; Azocines; Benzomorphans; Cyclazocine; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Muscle, Smooth; Naloxone; Narcotic Antagonists | 1982 |
Rimorphin, a unique, naturally occurring [Leu]enkephalin-containing peptide found in association with dynorphin and alpha-neo-endorphin.
Topics: Amino Acid Sequence; Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Hypothalamus; Pituitary Gland; Pituitary Gland, Posterior; Rats; Spinal Cord; Swine | 1982 |
Comparison of the distribution of dynorphin systems and enkephalin systems in brain.
Topics: Animals; Brain; Brain Mapping; Dynorphins; Endorphins; Enkephalins; Immunologic Techniques; Rats | 1982 |
Distinct distribution of immunoreactive dynorphin and leucine enkephalin in various populations of isolated adrenal cromaffin cells.
Topics: Animals; Cattle; Chromaffin System; Dynorphins; Endorphins; Enkephalin, Leucine; Epinephrine; Norepinephrine | 1983 |
Dynorphin-immunoreactive neurons in the central nervous system of the rat.
Topics: Animals; beta-Endorphin; Central Nervous System; Dynorphins; Endorphins; Enkephalins; Fluorescent Antibody Technique; Male; Rats; Rats, Inbred Strains | 1982 |
Opioid peptides in the hippocampus: anatomical and physiological considerations.
Topics: Animals; Dynorphins; Electroencephalography; Endorphins; Enkephalins; Hippocampus; Magnesium; Male; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Characterization of electrophoretically separable endorphins in human CSF.
Topics: beta-Endorphin; Chromatography, High Pressure Liquid; Dynorphins; Electrophoresis, Agar Gel; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Radioimmunoassay | 1983 |
Levels of pro-neo-endorphin/dynorphin-derived peptides in the hypothalamo-posterior pituitary system of male and female Brattleboro rats.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Female; Hypothalamus; Male; Peptides; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Brattleboro | 1983 |
Opioid peptide effects on insulin release and c-AMP in islets of Langerhans.
Topics: Animals; Cyclic AMP; Dynorphins; Endorphins; Enkephalins; Female; Insulin; Insulin Secretion; Islets of Langerhans; Naloxone; Rats; Rats, Inbred Strains | 1983 |
A novel opioid peptide, leumorphin, acts as an agonist at the kappa opiate receptor.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Naloxone; Neuromuscular Junction; Protein Precursors; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Swine; Vas Deferens | 1983 |
Rimorphin (dynorphin B) exists together with alpha-neo-endorphin and dynorphin (dynorphin A) in human hypothalamus.
Topics: Adult; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalin, Leucine; Female; Humans; Hypothalamus; Protein Precursors | 1983 |
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary.
Topics: Animals; beta-Endorphin; Brain Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalin, Leucine; Immune Sera; Male; Peptide Fragments; Peptides; Pituitary Gland; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Tissue Distribution | 1983 |
Separate origins for the dynorphin and enkephalin immunoreactive fibers in the inferior mesenteric ganglion of the guinea pig.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; Fluorescent Antibody Technique; Ganglia, Sympathetic; Guinea Pigs; Male; Nerve Fibers | 1983 |
Evidence for a selective processing of proenkephalin B into different opioid peptide forms in particular regions of rat brain and pituitary.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Brain; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Molecular Weight; Organ Specificity; Peptide Fragments; Pituitary Gland; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains | 1984 |
Opioid receptor selectivity of dynorphin gene products.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Peptide Fragments; Protein Precursors; Receptors, Opioid | 1984 |
Dynorphin-A alters the excitability of pyramidal neurons of the rat hippocampus in vitro.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Evoked Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Naloxone; Neurons; Peptide Fragments; Pyramidal Tracts; Rats | 1983 |
Ontogeny of opioid and related peptides in the rat cns and pituitary: an immunocytochemical study.
Topics: Aging; Animals; Brain; Dynorphins; Embryo, Mammalian; Endorphins; Enkephalin, Leucine; Female; Peptide Fragments; Pituitary Gland; Pituitary Hormones, Anterior; Pregnancy; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Inbred Strains | 1983 |
Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalins; Hippocampus; Kinetics; Male; Peptide Fragments; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains | 1983 |
Dynorphin converting enzyme with unusual specificity from rat brain.
Topics: Animals; Brain; Cysteine Endopeptidases; Dynorphins; Endopeptidases; Endorphins; Enkephalins; Hydrogen-Ion Concentration; Kinetics; Male; Peptide Fragments; Protease Inhibitors; Protein Precursors; Rats; Substrate Specificity | 1984 |
The distribution and morphology of opioid peptide immunoreactive neurons in the cerebral cortex of rats.
Topics: Animals; Cerebral Cortex; Dynorphins; Endorphins; Enkephalins; Female; Hippocampus; Male; Neurons; Olfactory Bulb; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred F344; Rats, Inbred Strains; Tissue Distribution | 1984 |
Solubilization in high yield of opioid receptors retaining high-affinity delta, mu and kappa binding sites.
Topics: Animals; Binding Sites; Brain Chemistry; Cell Membrane; Chemical Precipitation; Detergents; Digitonin; Drug Stability; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Magnesium; Peptide Fragments; Polyethylene Glycols; Rats; Receptors, Opioid; Solubility | 1984 |
Immunoreactive leu-enkephalin in the monkey hypothalamus including observations on its ultrastructural localization in the paraventricular nucleus.
Topics: Animals; Cross Reactions; Dynorphins; Endorphins; Enkephalin, Leucine; Hypothalamus; Immunoenzyme Techniques; Macaca fascicularis; Microscopy, Electron; Neuroglia; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Synapses | 1984 |
Dynorphin reduces calcium-dependent action potential duration by decreasing voltage-dependent calcium conductance.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Dynorphins; Endorphins; Enkephalin, Leucine; Ganglia, Spinal; Ion Channels; Mice; Naloxone; Peptide Fragments; Receptors, Opioid | 1984 |
Proenkephalin B (prodynorphin)-derived opioid peptides: evidence for a differential processing in lobes of the pituitary.
Topics: Animals; beta-Endorphin; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Molecular Weight; Peptide Fragments; Pituitary Gland; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Characterization of enkephalins and related peptides in rat hypophysial portal blood.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Peptide Fragments; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains | 1984 |
Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Cyclazocine; Dynorphins; Electric Conductivity; Enkephalins; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Dynorphin-(1-13) restores the potency of morphine on the tolerant guinea pig ileum.
Topics: Animals; beta-Endorphin; Cyclazocine; Drug Interactions; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments | 1984 |
Subcellular distribution of opioid peptides in rat hypothalamus and pituitary.
Topics: Animals; Arginine Vasopressin; Centrifugation, Density Gradient; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Male; Peptide Fragments; Pituitary Gland; Protein Precursors; Rats; Rats, Inbred Strains; Subcellular Fractions; Synaptic Vesicles; Synaptosomes | 1984 |
Benzomorphan sites are ligand recognition sites of putative epsilon-receptors.
Topics: Animals; Benzomorphans; beta-Endorphin; Binding, Competitive; Brain; Cell Membrane; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Guinea Pigs; Humans; Kinetics; Morphinans; Peptide Fragments; Placenta; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Human leumorphin is a potent, kappa opioid receptor agonist.
Topics: Animals; Benzomorphans; Depression, Chemical; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Humans; Ileum; Male; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Swine; Vas Deferens | 1984 |
[Endogenous morphine-like substances: biogenesis, release and degradation].
Topics: Animals; DNA, Recombinant; Dynorphins; Endorphins; Enkephalins; Gene Expression Regulation; Humans; In Vitro Techniques; Pituitary Gland; Protease Inhibitors; Protein Biosynthesis | 1984 |
Primate model of Parkinson's disease: alterations in multiple opioid systems in the basal ganglia.
Topics: Animals; Basal Ganglia; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Macaca mulatta; Male; Nucleus Accumbens; Parkinson Disease; Protein Precursors; Substantia Nigra | 1984 |
Ontogenetic development of the pro-enkephalin B (= pro-dynorphin) opioid peptide system in the rat pituitary.
Topics: Animals; Animals, Newborn; Cell Differentiation; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Female; Male; Molecular Weight; Oxytocin; Peptide Fragments; Peptides; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Pregnancy; Protein Precursors; Rats; Rats, Inbred Strains; Vasopressins | 1984 |
Characteristics of 3H-tifluadom binding in guinea-pig brain membranes.
Topics: Animals; Benzodiazepines; Benzomorphans; Binding Sites; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Morphine; Receptors, Opioid | 1984 |
Differential effects of various opioid peptides on vasopressin and oxytocin release from the rat pituitary in vitro.
Topics: Animals; beta-Endorphin; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Female; In Vitro Techniques; Naloxone; Oxytocin; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains; Vasopressins | 1984 |
Effects of dynorphin A (1-17), dynorphin A (1-13) and D-ala2-D-leu5-enkephalin on the excitability of pyramidal cells in CA1 and CA2 of the rat hippocampus in vitro.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evoked Potentials; Hippocampus; In Vitro Techniques; Peptide Fragments; Rats; Receptors, Opioid | 1984 |
Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1-17) on neocortical neurons in vitro.
Topics: Animals; Cerebral Cortex; Dynorphins; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Neurons; Peptide Fragments; Rats; Rats, Inbred Strains | 1984 |
Dynorphin reduces voltage-dependent calcium conductance of mouse dorsal root ganglion neurons.
Topics: Action Potentials; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Ganglia, Spinal; In Vitro Techniques; Mice; Neurons; Receptors, Opioid | 1984 |
ICI 174864, a putative delta opioid antagonist, reverses endotoxemic hypotension: pretreatment with dynorphin 1-13, A kappa agonist, blocks this action.
Topics: Animals; Blood Pressure; Dynorphins; Enkephalin, Leucine; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Shock, Septic | 1984 |
Anatomical relationship between opioid peptides and receptors in rhesus monkey brain.
Topics: Animals; Benzomorphans; Brain; Brain Mapping; Dynorphins; Endorphins; Enkephalins; Macaca mulatta; Naloxone; Pro-Opiomelanocortin; Radioligand Assay; Receptors, Opioid; Synaptic Transmission | 1984 |
Effect of hemorrhage on vasopressin, dynorphin A, and leu5-enkephalin in the hypothalamo-pituitary system of the rat.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Dynorphins; Enkephalin, Leucine; Heart Rate; Hematocrit; Hemorrhage; Hypothalamo-Hypophyseal System; Pituitary Gland, Anterior; Rats; Shock, Hemorrhagic; Supraoptic Nucleus | 1984 |
[Inhibitory effects of dynorphin on electric field stimulation induced contraction of blood vessels in vitro].
Topics: Animals; Dogs; Dynorphins; Ear; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; In Vitro Techniques; Mesenteric Arteries; Naloxone; Rabbits; Receptors, Opioid; Vasoconstriction | 1984 |
Opioid-mediated acute responses to alcohol: ethanol potentiates opioid actions on the guinea pig ileum.
Topics: Acetylcholine; Animals; Drug Interactions; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Substance P | 1983 |
Asbestos-related increase in pulmonary levels of vasoactive intestinal peptide (VIP).
Topics: Animals; Asbestos; Bronchi; Dynorphins; Endorphins; Enkephalin, Leucine; Lung; Male; Neurotensin; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Substance P; Therapeutic Irrigation; Vasoactive Intestinal Peptide | 1983 |
Dynorphin and enkephalins in adrenal paraneurones. Opiates in the adrenal medulla.
Topics: Adrenal Medulla; Animals; Bombesin; Catecholamines; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Epinephrine; Fluorescent Antibody Technique; In Vitro Techniques; Neurons; Norepinephrine; Peptide Fragments; Radioimmunoassay; Substance P; Vasoactive Intestinal Peptide | 1984 |
Peptides and nociception.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Bombesin; Bradykinin; Cholecystokinin; Dynorphins; Endorphins; Enkephalins; Melanocyte-Stimulating Hormones; Mice; Nervous System; Neurotensin; Pain; Peptide Fragments; Peptides; Rats; Somatostatin; Substance P; Thyrotropin-Releasing Hormone; Vasopressins | 1984 |
The immunohistochemical localization of nine peptides in the sacral parasympathetic nucleus and the dorsal gray commissure in rat spinal cord.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; FMRFamide; Immunoenzyme Techniques; Male; Neurotensin; Oligopeptides; Pancreatic Polypeptide; Parasympathetic Nervous System; Peptide Fragments; Peptides; Rats; Somatostatin; Spinal Cord; Substance P; Vasoactive Intestinal Peptide | 1984 |
Histamine release induced by dynorphin-(1-13) from rat mast cells.
Topics: Animals; Calcium Chloride; Cromolyn Sodium; Dynorphins; Enkephalin, Leucine; Histamine Release; Hydrogen-Ion Concentration; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mast Cells; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Temperature; Time Factors | 1984 |
Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus.
Topics: Animals; Binding, Competitive; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Peptide Fragments; Receptors, Opioid | 1981 |
Behavioral and neurochemical effects of the new opioid peptide dynorphin--(1-13): comparison with other neuropeptides.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Brain Chemistry; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Grooming; Injections, Intraventricular; Peptide Fragments; Peptides; Rats | 1981 |
Levels of dynorphin-(1-13) immunoreactivity in rat neurointermediate pituitaries are concomitantly altered with those of leucine enkephalin and vasopressin in response to various endocrine manipulations.
Topics: Adrenalectomy; Animals; beta-Endorphin; Dehydration; Dexamethasone; Diabetes Insipidus; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Peptide Fragments; Pituitary Gland; Rats; Rats, Inbred Strains; Sodium Chloride; Vasopressins | 1981 |
Evidence that inhibition of nicotine-mediated catecholamine secretion from adrenal chromaffin cells by enkephalin, beta-endorphin, dynorphin (1-13), and opiates is not mediated via specific opiate receptors.
Topics: Adrenal Glands; Animals; beta-Endorphin; Cattle; Chromaffin Granules; Chromaffin System; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Kinetics; Morphine; Narcotics; Nicotine; Norepinephrine; Peptide Fragments; Structure-Activity Relationship | 1982 |
Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy.
Topics: Analgesia; Analgesics; Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mice; Morphine; Naloxone; Peptide Fragments; Receptors, Opioid | 1981 |
Synthesis of porcine leumorphin and some of its biological activities.
Topics: Analgesia; Animals; beta-Endorphin; Biological Assay; Dynorphins; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; Ileum; Indicators and Reagents; Mice; Muscle Contraction; Naloxone; Narcotics; Peptide Fragments; Protein Precursors; Swine | 1983 |
Dynorphin-(1-13): the effect of in vivo treatment on opiate bindings in vitro.
Topics: Animals; Brain; Dihydromorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Peptide Fragments; Receptors, Opioid | 1983 |
Comparison of the action of putative endogenous kappa-agonists, leumorphin and rimorphin in vitro.
Topics: Animals; Biological Assay; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Vas Deferens | 1983 |
Comparison of the effectiveness of different opioid peptides in suppressing heroin withdrawal.
Topics: Adult; Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heroin; Humans; Male; Mice; Peptide Fragments; Protein Precursors; Substance Withdrawal Syndrome | 1984 |
Analgesia induced by intrathecal injection of dynorphin B in the rat.
Topics: Analgesics; Animals; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Female; Injections, Spinal; Morphine; Naloxone; Rats | 1984 |
Synthesis of a newly isolated opioid tridecapeptide, rimorphin, from pituitary using a trifluoroacetic acid-thioanisole deprotection system.
Topics: Amino Acid Sequence; Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; In Vitro Techniques; Mice; Muscle Contraction; Muscle, Smooth | 1983 |
Head group and structure specific interactions of enkephalins and dynorphin with liposomes: investigation by hydrophobic photolabeling.
Topics: Amino Acid Sequence; Azirines; Chymotrypsin; Dynorphins; Endorphins; Enkephalins; Lipid Bilayers; Peptide Fragments; Structure-Activity Relationship | 1983 |
Leumorphin is a novel endogenous opioid peptide derived from preproenkephalin B.
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Electrophoresis, Polyacrylamide Gel; Endorphins; Enkephalin, Leucine; Enkephalins; Pituitary Gland; Protein Precursors; Radioimmunoassay; Swine | 1983 |
Sensitivity to morphine-evoked bradycardia in rats is modified by dynorphin (1-13), Leu- and Met-enkephalin.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Heart Rate; Male; Morphine; Peptide Fragments; Rats; Rats, Inbred Strains | 1984 |
Distribution of immunoreactive dynorphin B in discrete areas of the rat brain and spinal cord.
Topics: Animals; Brain Chemistry; Diencephalon; Dynorphins; Endorphins; Enkephalin, Leucine; Hypothalamus; Male; Medulla Oblongata; Mesencephalon; Pituitary Gland; Pons; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Telencephalon | 1984 |
Fluorescence study on the solution conformation to dynorphin in comparison of enkephalin.
Topics: Dynorphins; Endorphins; Energy Transfer; Enkephalin, Leucine; Peptide Fragments; Protein Conformation; Solutions; Spectrometry, Fluorescence; Structure-Activity Relationship | 1983 |
Direct pituitary stimulation of thyrotropin secretion by opioid peptides.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; In Vitro Techniques; Kinetics; Male; Naloxone; Narcotics; Peptide Fragments; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thyrotropin | 1983 |
A specific radioimmunoassay for the opioid peptide dynorphin B in neural tissues.
Topics: Animals; Brain Chemistry; Dynorphins; Endorphins; Enkephalin, Leucine; Immune Sera; Male; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Tissue Distribution | 1982 |
Behavioral effects and in vivo degradation of intraventricularly administered dynorphin-(1-13) and D-Ala2-dynorphin-(1-11) in rats.
Topics: Analgesics; Animals; Behavior, Animal; Catalepsy; Dynorphins; Endorphins; Enkephalins; Humans; Kinetics; Male; Peptide Fragments; Rats; Structure-Activity Relationship | 1980 |
Evidence for the occurrence of the opioid octapeptide dynorphin-(1-8) in the neurointermediate pituitary of rats.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Peptide Fragments; Pituitary Gland, Posterior; Radioimmunoassay; Rats; Rats, Inbred Strains | 1981 |
Time-course of neuropeptide changes in peri-ischemic zone and amygdala following focal ischemia in rats.
Topics: Amygdala; Animals; Cerebral Cortex; Dynorphins; Enkephalin, Leucine; Ischemic Attack, Transient; Male; Neuropeptide Y; Neuropeptides; Neurotensin; Rats; Rats, Wistar; Time Factors; Tyrosine 3-Monooxygenase | 1995 |
Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum.
Topics: Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 1993 |
Rostrocaudal subregional differences in the response of enkephalin, dynorphin and substance P synthesis in rat nucleus accumbens to dopamine depletion.
Topics: Animals; Dopamine; Dynorphins; Enkephalins; Male; Neural Pathways; Nucleus Accumbens; Oxidopamine; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine; RNA, Messenger; Substance P; Tachykinins | 1994 |
[Expression of nitric oxide synthase in enkephalin and dynorphin systems of the rat hypothalamus].
Topics: Amino Acid Oxidoreductases; Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Histocytochemistry; Hypothalamus; Immunohistochemistry; Male; NADPH Dehydrogenase; Neurons; Nitric Oxide Synthase; Rats | 1994 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Alterations in mRNA levels of D2 receptors and neuropeptides in striatonigral and striatopallidal neurons of rats with neuroleptic-induced dyskinesias.
Topics: Animals; Basal Ganglia Diseases; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Glutamate Decarboxylase; Haloperidol; In Situ Hybridization; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance P | 1994 |
Current bibliographies of neuropeptides prepared by the University of Sheffield Biomedical Information Services.
Topics: Angiotensin II; Animals; Dynorphins; Endorphins; Enkephalins; Humans; Narcotics; Neuropeptides; Neurotensin; Substance P | 1995 |
Current bibliographies of neuropeptides prepared by the University of Sheffield Biomedical Information Service.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; Humans; Narcotics; Neuropeptides; Neurotensin; Substance P; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 1995 |
Brain dynorphin and enkephalin systems in Fischer and Lewis rats: effects of morphine tolerance and withdrawal.
Topics: Amino Acid Sequence; Animals; Body Weight; Brain Chemistry; Drug Tolerance; Dynorphins; Enkephalins; Female; Male; Molecular Sequence Data; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred F344; Rats, Inbred Lew; Species Specificity; Substance Withdrawal Syndrome | 1995 |
Purification and characterization of a dynorphin-processing endopeptidase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Dynorphins; Endorphins; Enkephalins; Isoelectric Point; Kinetics; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Pituitary Gland; Protein Precursors; Protein Processing, Post-Translational; Serine Endopeptidases; Substrate Specificity | 1995 |
The effects of morphine treatment and morphine withdrawal on the dynorphin and enkephalin systems in Sprague-Dawley rats.
Topics: Analysis of Variance; Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Male; Morphine; Naloxone; Peptides; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1995 |
Effects of streptozotocin-induced diabetes on prodynorphin-derived peptides in rat brain regions.
Topics: Animals; Brain; Diabetes Mellitus, Experimental; Dynorphins; Enkephalins; Hypothalamic Hormones; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1995 |
Expression of enkephalin and dynorphin precursor mRNAs in brain areas of hypo-and hyperthyroid rat: effect of kainic acid injection.
Topics: Animals; Brain Chemistry; Dynorphins; Enkephalins; Excitatory Amino Acid Agonists; Hyperthyroidism; Hypothyroidism; In Situ Hybridization; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thyroxine; Triiodothyronine; Up-Regulation | 1995 |
Synthesis and opioid activities of [D-Leu-8]Dynorphin(1-8) analogs containing a reduced peptide bond, psi(CH2-NH).
Topics: Amino Acid Sequence; Analgesics; Animals; Binding, Competitive; Cerebellum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Opioid Peptides; Receptors, Opioid | 1995 |
Processing of prodynorphin-derived peptides in striatal extracts. Identification by electrospray ionization mass spectrometry linked to size-exclusion chromatography.
Topics: Animals; Anti-Bacterial Agents; Chromatography, Gel; Corpus Striatum; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Mass Spectrometry; Peptide Hydrolases; Peptides; Protein Precursors; Rats; Sensitivity and Specificity; Tissue Extracts | 1995 |
Alterations in striatal zif/268, preprodynorphin and preproenkephalin mRNA expression induced by repeated amphetamine administration in rats.
Topics: Amphetamine; Animals; Caudate Nucleus; Dynorphins; Enkephalins; Gene Expression; Genes, Immediate-Early; In Situ Hybridization; Male; Nucleus Accumbens; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Zinc Fingers | 1995 |
Cocaine binges differentially alter striatal preprodynorphin and zif/268 mRNAs.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Corpus Striatum; Disease Models, Animal; DNA-Binding Proteins; Drug Administration Schedule; Dynorphins; Early Growth Response Protein 1; Enkephalins; Immediate-Early Proteins; Male; Nerve Tissue Proteins; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors | 1995 |
Short-term cocaine self administration alters striatal gene expression.
Topics: Animals; Cocaine; Dynorphins; Enkephalins; Gene Expression; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Neostriatum; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Self Administration | 1995 |
Chronic blockade of muscarinic cholinergic receptors by systemic trihexyphenidyl (Artane) administration modulates but does not mediate the dopaminergic regulation of striatal prepropeptide messenger RNA expression.
Topics: Animals; Autoradiography; Dopamine; Dynorphins; Enkephalins; In Situ Hybridization; Male; Muscarinic Antagonists; Neostriatum; Oxidopamine; Pirenzepine; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Substantia Nigra; Sympathectomy, Chemical; Tachykinins; Trihexyphenidyl | 1995 |
Spinal cord dynorphin precursor intermediates decline during late gestation.
Topics: Analgesia; Animals; Dynorphins; Enkephalin, Leucine; Female; Molecular Weight; Pregnancy; Pregnancy, Animal; Protein Precursors; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors; Trypsin | 1995 |
Molecular alterations in the neostriatum of human cocaine addicts.
Topics: Adolescent; Adult; Autoradiography; Cocaine; Dynorphins; Enkephalins; Female; Histocytochemistry; Humans; In Situ Hybridization; Male; Middle Aged; Neostriatum; Nucleus Accumbens; Putamen; Receptors, Dopamine; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Substance P; Substance-Related Disorders | 1993 |
Brain and plasma levels of opioid peptides are altered in rats with thioacetamide-induced fulminant hepatic failure: implications for the treatment of hepatic encephalopathy with opioid antagonists.
Topics: Animals; beta-Endorphin; Brain Chemistry; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hepatic Encephalopathy; Male; Motor Activity; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Sprague-Dawley; Thioacetamide | 1995 |
Behavioral and neurochemical effects of opioids in the paramedian midbrain tegmentum including the median raphe nucleus and ventral tegmental area.
Topics: Animals; Brain Chemistry; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Male; Morphine; Motor Activity; Naloxone; Neurotransmitter Agents; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Tegmental Area | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Specific N- or C-terminus modified dynorphin and beta-endorphin peptides can selectively block excitatory opioid receptor functions in sensory neurons and unmask potent inhibitory effects of opioid agonists.
Topics: Action Potentials; Animals; beta-Endorphin; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Mice; Morphine; Neurons; Receptors, Opioid, delta | 1995 |
Opioid precursor gene expression in the human hypothalamus.
Topics: Adolescent; Adult; Dynorphins; Enkephalins; Gene Expression; Histocytochemistry; Humans; Hypothalamus; In Situ Hybridization; Male; Middle Aged; Neurons; Pro-Opiomelanocortin; Protein Precursors; Sensitivity and Specificity | 1995 |
Elevation of striatal and accumbal preproenkephalin, preprotachykinin and preprodynorphin mRNA abundance subsequent to N-methyl-D-aspartate receptor blockade with MK-801.
Topics: Animals; Base Sequence; Corpus Striatum; Dizocilpine Maleate; Dynorphins; Enkephalins; Male; Molecular Probes; Molecular Sequence Data; Neuropeptides; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tachykinins | 1995 |
Forskolin induces preproenkephalin and preprodynorphin mRNA in rat striatum as demonstrated by in situ hybridization histochemistry.
Topics: Animals; Colforsin; Corpus Striatum; Dynorphins; Enkephalins; Histocytochemistry; In Situ Hybridization; Injections, Intraventricular; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
[Participation of central opiate receptors in the pathogenesis of adrenal arrhythmias].
Topics: Adrenal Gland Diseases; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Wistar; Receptors, Opioid | 1994 |
Acute and chronic cocaine administration differentially alters striatal opioid and nuclear transcription factor mRNAs.
Topics: Animals; Cell Nucleus; Cocaine; Dynorphins; Endorphins; Enkephalins; Gene Expression Regulation; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Neostriatum; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors | 1994 |
Opioid modulation of oxytocin release from spinal cord synaptosomes.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Naloxone; Nerve Endings; Oxytocin; Potassium Chloride; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord; Synaptosomes | 1994 |
Prodynorphin-derived peptide expression in primate cortex and striatum.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dynorphins; Endorphins; Enkephalins; Macaca nemestrina; Peptide Fragments; Protein Precursors; Tissue Distribution | 1994 |
Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver.
Topics: Animals; Cholestasis; Dynorphins; Enkephalins; Histocytochemistry; Immunohistochemistry; Liver; Male; Necrosis; Nucleic Acid Hybridization; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution | 1995 |
The relationship between MRNA levels and the locomotor response to novelty.
Topics: Animals; Blotting, Northern; Cholecystokinin; Dopamine; Dynorphins; Enkephalins; Exploratory Behavior; Genetic Code; Glutamate Decarboxylase; Male; Motor Activity; Neurotensin; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tachykinins; Tyrosine 3-Monooxygenase | 1994 |
Effects of chronic food restriction on prodynorphin-derived peptides in rat brain regions.
Topics: Animals; Diet; Dynorphins; Enkephalins; Hypothalamic Hormones; Male; Neuropeptides; Peptide Fragments; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Estrogen regulation of prodynorphin gene expression in the rat adenohypophysis: effect of the antiestrogen tamoxifen.
Topics: Animals; Dynorphins; Enkephalins; Estradiol; Female; Gene Expression; Ovariectomy; Pituitary Gland, Anterior; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tamoxifen; Transcription, Genetic | 1995 |
Influence of hypertension development on rat tail artery responses to opioid peptides.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Tail; Vasoconstriction | 1995 |
Receptor-selective opioid peptides fail to affect behavioral responses induced by a low dose of apomorphine in the mouse.
Topics: Analgesics; Animals; Apomorphine; Behavior, Animal; Benzazepines; Dopamine Agents; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Grooming; Male; Mice; Mice, Inbred Strains; Motor Activity; Peptide Fragments; Receptors, Opioid; Stereotyped Behavior | 1993 |
Augmenting effect of opioid peptides on murine macrophage activation.
Topics: Animals; beta-Endorphin; Cells, Cultured; Dynorphins; Endorphins; Enkephalins; Female; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Naloxone | 1994 |
Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Barium Compounds; Cadmium; Carbachol; Chlorides; Computer Simulation; Dynorphins; Electrophysiology; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Models, Neurological; Naloxone; Narcotics; Neurons; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Convulsant doses of cocaine alter immediate early gene and opioid peptide expression in rat limbic forebrain.
Topics: Animals; Cocaine; Convulsants; DNA-Binding Proteins; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Immediate-Early Proteins; In Situ Hybridization; Kindling, Neurologic; Limbic System; Male; Nerve Tissue Proteins; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Seizures; Time Factors; Transcription Factors | 1993 |
Opioid peptide gene expression in the nucleus tractus solitarius of rat brain and increases induced by unilateral cervical vagotomy: implications for role of opioid neurons in respiratory control mechanisms.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; Ganglionectomy; Gene Expression; In Situ Hybridization; Male; Medulla Oblongata; Neck; Neurons; Nodose Ganglion; Protein Precursors; Rats; Rats, Sprague-Dawley; Respiratory System; RNA, Messenger; Vagotomy | 1993 |
Dynorphin gene expression and release in the myocardial cell.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Cells, Cultured; Cytosol; Dynorphins; Enkephalins; Gene Expression; Heart; Heart Ventricles; Male; Myocardium; Potassium Chloride; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; RNA, Messenger | 1994 |
Morphine-induced reciprocal alterations in G alpha s and opioid peptide mRNA levels in discrete brain regions.
Topics: Analysis of Variance; Animals; Blotting, Northern; Brain Chemistry; Drug Tolerance; Dynorphins; Enkephalins; Gene Expression; GTP-Binding Proteins; Hypothalamus; Male; Morphine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Kappa-selective agonists decrease postsynaptic potentials and calcium components of action potentials in the supraoptic nucleus of rat hypothalamus in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics; Animals; Benzomorphans; Calcium; Cesium; Dynorphins; Electric Stimulation; Electrophysiology; Enkephalins; Humans; In Vitro Techniques; Male; Membrane Potentials; Narcotic Antagonists; Neurosecretory Systems; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Supraoptic Nucleus; Synapses; Tetraethylammonium Compounds | 1994 |
Dynorphin A-(1-13) potently improves the impairment of spontaneous alternation performance induced by the mu-selective opioid receptor agonist DAMGO in mice.
Topics: Analgesics; Animals; Behavior, Animal; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Memory; Memory Disorders; Mice; Mice, Inbred Strains; Peptide Fragments; Physostigmine; Receptors, Opioid, mu | 1994 |
Acute amphetamine or methamphetamine alters opioid peptide mRNA expression in rat striatum.
Topics: Amphetamine; Animals; Corpus Striatum; Dynorphins; Enkephalins; Male; Methamphetamine; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger | 1994 |
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
Topics: Analysis of Variance; Animals; Antibodies; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclosporine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Inflammation; Injections; Interleukin-1; Male; Naloxone; Pain; Rats; Rats, Wistar; Recombinant Proteins; Regression Analysis; Somatostatin | 1994 |
Facilitation of self-stimulation of ventral tegmentum by microinjection of opioid receptor subtype agonists.
Topics: Analgesics; Animals; Brain Mapping; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Hypothalamic Area, Lateral; Male; Medial Forebrain Bundle; Motivation; Naloxone; Neural Pathways; Rats; Rats, Wistar; Receptors, Opioid; Self Stimulation; Substantia Nigra; Tegmentum Mesencephali; Ventral Tegmental Area | 1994 |
Behavioral effects of systemically administered mu and kappa opioid agonists in the squirrel monkey: peptides versus alkaloids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alkaloids; Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intramuscular; Male; Morphine; Peptide Fragments; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule; Saimiri | 1994 |
[Alteration of dynorphin1-8 and leu-enkephalin in rat hippocampus during seizure and electroacupuncture].
Topics: Animals; Dynorphins; Electroacupuncture; Enkephalin, Leucine; Epilepsy; Female; Hippocampus; Immunohistochemistry; Male; Penicillins; Peptide Fragments; Rats; Rats, Wistar | 1994 |
Endogenous opioid-like substances in perinatal asphyxia and cerebral injury due to anoxia.
Topics: Asphyxia Neonatorum; beta-Endorphin; Cerebral Hemorrhage; Dynorphins; Enkephalin, Leucine; Female; Fetal Hypoxia; Humans; Infant, Newborn; Male; Peptide Fragments; Pregnancy | 1993 |
Effect of opioid peptides on dopamine release from nucleus accumbens after repeated treatment with methamphetamine.
Topics: Analgesics; Animals; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraperitoneal; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Wistar | 1994 |
[3H]dynorphin1-8 binding sites in frog (Rana esculenta) brain membranes.
Topics: Amino Acid Sequence; Animals; Brain; Cell Membrane; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Naloxone; Peptide Fragments; Rana esculenta; Receptors, Opioid; Sodium Chloride; Tritium | 1994 |
Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras.
Topics: Amino Acid Sequence; Base Sequence; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Molecular Sequence Data; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides | 1994 |
Difference between plasma N- and C-terminally directed beta-endorphin immunoreactivity in infantile autism.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Autistic Disorder; beta-Endorphin; Child; Child, Preschool; Dopamine; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Female; Humans; Male; Norepinephrine; Opioid Peptides; Peptide Termination Factors; Pro-Opiomelanocortin; Radioimmunoassay; Rett Syndrome | 1994 |
Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.
Topics: Amino Acid Sequence; Animals; Association Learning; Autoradiography; Brain Mapping; Conditioning, Operant; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamus, Middle; Injections, Intraventricular; Limbic System; Male; Microinjections; Molecular Sequence Data; Motivation; Narcotics; Nucleus Accumbens; Peptide Fragments; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substantia Nigra | 1993 |
Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius.
Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Benzeneacetamides; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Medulla Oblongata; Potassium Channels; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synaptic Transmission | 1993 |
[Changes of endogenous opioid peptides content in RPGL during acupuncture analgesia].
Topics: Acupuncture Analgesia; Animals; beta-Endorphin; Dynorphins; Electroacupuncture; Enkephalin, Leucine; Male; Medulla Oblongata; Pain Threshold; Peptide Fragments; Rats; Reticular Formation | 1993 |
Cyclic AMP mediates mu and delta, but not kappa opioid analgesia in the spinal cord of the rat.
Topics: Analgesia; Analgesics; Animals; Bucladesine; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Pain; Peptide Fragments; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1993 |
Endogenous opioid regulation of oxytocin secretion through pregnancy in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Pregnancy; Pregnancy, Animal; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Vasopressins | 1993 |
Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum: role of opiates and 5-hydroxytryptamine.
Topics: Analgesics; Animals; Atropine; Autonomic Nervous System; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Rats; Rats, Wistar; Serotonin; Synaptic Transmission; Tetrodotoxin | 1993 |
Cloning and expression of a cDNA for the rat kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Base Sequence; Cells, Cultured; Cloning, Molecular; DNA; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sequence Homology, Amino Acid | 1993 |
Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Benzomorphans; beta-Endorphin; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Pain Measurement; Pyrrolidines; Spinal Cord; Time Factors | 1993 |
Regulatory role of enteric kappa opioid receptors in human colonic motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Colon, Sigmoid; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Gastrointestinal Motility; Humans; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Opioid peptide administration and memory formation: effects of administration vehicle.
Topics: Animals; Avoidance Learning; Chickens; Dynorphins; Endorphins; Enkephalin, Leucine; Memory; Narcotics; Peptide Fragments; Pharmaceutical Vehicles; Solutions | 1993 |
Dynorphin modulates prolactin secretion in the turkey.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Prolactin; Protein Precursors; Turkeys | 1993 |
Expression of prodynorphin-derived peptides and mRNA in guinea-pig cortex.
Topics: Animals; Blotting, Northern; Cerebral Cortex; Corpus Striatum; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Male; Organ Specificity; Peptide Fragments; Protein Precursors; Radioimmunoassay; RNA, Messenger | 1993 |
Collision-induced dissociation of multiply charged peptides in an ion-trap storage/reflectron time-of-flight mass spectrometer.
Topics: Amino Acid Sequence; Angiotensins; Bradykinin; Dynorphins; Enkephalin, Leucine; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Neurotensin; Peptide Fragments; Peptides | 1995 |
Early changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures in the rat.
Topics: Amygdala; Animals; Blotting, Northern; Dynorphins; Enkephalins; Kindling, Neurologic; Male; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA Probes; RNA, Messenger; Seizures | 1995 |
Phorbol ester regulation of opioid peptide gene expression in myocardial cells. Role of nuclear protein kinase.
Topics: Alkaloids; Animals; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalins; Enzyme Inhibitors; Gene Expression; Heart Ventricles; Isoenzymes; Kinetics; Male; Myocardium; Phorbol Esters; Protein Kinase C; Protein Precursors; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1995 |
Ion dissociation reactions induced in a high-pressure quadrupole collision cell.
Topics: Amino Acid Sequence; Argon; Chemical Phenomena; Chemistry, Physical; Dynorphins; Enkephalin, Leucine; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Quaternary Ammonium Compounds | 1995 |
Neurochemical changes following occlusion of the middle cerebral artery in rats.
Topics: Amygdala; Animals; Brain Chemistry; Brain Ischemia; Brain Stem; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Dynorphins; Enkephalin, Leucine; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Prefrontal Cortex; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 1995 |
Dopamine receptor mRNA expression patterns by opioid peptide cells in the nucleus accumbens of the rat: a double in situ hybridization study.
Topics: Animals; Caudate Nucleus; Dynorphins; Enkephalins; In Situ Hybridization; Male; Neurons; Nucleus Accumbens; Protein Precursors; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; RNA, Messenger | 1995 |
Characterization of the aminopeptidase activity of epidermal leukotriene A4 hydrolase against the opioid dynorphin fragment 1-7.
Topics: Amino Acid Sequence; Aminopeptidases; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Epidermis; Epoxide Hydrolases; Humans; Molecular Sequence Data; Neutrophils; Peptide Fragments; Tyrosine | 1995 |
The use of dodecylphosphocholine micelles in solution NMR.
Topics: Dynorphins; Enkephalin, Leucine; Humans; Magnetic Resonance Spectroscopy; Micelles; Phosphorylcholine; Protein Conformation | 1995 |
Memory retrieval enhancement by kappa opioid agonist and mu, delta antagonists.
Topics: Analysis of Variance; Animals; Dynorphins; Enkephalin, Leucine; Male; Memory; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Endogenous opioid peptides in parasympathetic, sympathetic and sensory nerves in the guinea-pig heart.
Topics: Adrenergic Fibers; Animals; Antibody Specificity; Axons; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Ganglia, Autonomic; Guinea Pigs; Heart; Immunohistochemistry; Male; Neurons, Afferent; Opioid Peptides; Parasympathetic Fibers, Postganglionic; Protein Precursors | 1996 |
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.
Topics: Amphetamine; Animals; Carrier Proteins; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Female; Gene Expression Regulation; Gene Targeting; Locomotion; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Protein Precursors; Rats | 1996 |
Neuropeptide changes following excitotoxic lesion of the insular cortex in rats.
Topics: Amygdala; Animals; Cerebral Cortex; Dynorphins; Enkephalin, Leucine; Immunohistochemistry; Male; Neuropeptide Y; Neuropeptides; Neurotensin; Neurotoxins; Rats; Rats, Wistar | 1995 |
Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Binding; Protein Conformation; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1996 |
Dopaminergic regulation of striatonigral tachykinin and dynorphin gene expression: a study with the dopamine uptake inhibitor GBR-12909.
Topics: Animals; Cell Nucleus; Corpus Striatum; Denervation; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Female; Gene Expression Regulation; Kinetics; Organ Specificity; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Tachykinins; Transcription, Genetic | 1996 |
Distribution of preproenkephalin, preprotachykinin A, and preprodynorphin mRNAs in the rat nucleus accumbens: effect of repeated administration of nicotine.
Topics: Animals; Dynorphins; Enkephalins; In Situ Hybridization; Male; Nicotine; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tachykinins | 1996 |
State-dependent changes of brain endogenous opioids in mammalian hibernation.
Topics: Animals; beta-Endorphin; Brain; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Hibernation; Male; Opioid Peptides; Radioimmunoassay; Sciuridae | 1996 |
Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Oxidopamine; Peptide Fragments; Receptors, Opioid | 1995 |
Prenatal morphine exposure differentially alters expression of opioid peptides in striatum of newborns.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Brain; Corpus Striatum; Dynorphins; Enkephalin, Methionine; Enkephalins; Female; Frontal Lobe; Gene Expression; Hippocampus; Hypothalamus; Morphine; Multivariate Analysis; Organ Specificity; Pregnancy; Prenatal Exposure Delayed Effects; Protein Biosynthesis; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
[Effect of antiserum against dynorphin A administered intrathecally on spinal cord injury (SCI) of rats and its significance].
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Immune Sera; Immunization, Passive; Injections, Spinal; Male; Motor Activity; Neutralization Tests; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 1995 |
D1 and D2 receptor regulation of preproenkephalin and preprodynorphin mRNA in rat striatum following acute injection of amphetamine or methamphetamine.
Topics: Amphetamine; Analysis of Variance; Animals; Corpus Striatum; Dynorphins; Enkephalins; In Situ Hybridization; Male; Methamphetamine; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine; RNA, Messenger | 1996 |
Chronic intracerebroventricular administration of beta-endorphin augments natural killer cell cytotoxicity in rats.
Topics: Administration, Cutaneous; Animals; beta-Endorphin; Cytotoxicity, Immunologic; Dynorphins; Enkephalins; Injections, Intraventricular; Killer Cells, Natural; Lymphocyte Activation; Lymphoma; Male; Rats; Rats, Inbred SHR; Tumor Cells, Cultured | 1996 |
Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum.
Topics: Animals; Corpus Striatum; Dynorphins; Enkephalins; Male; Neural Pathways; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Substance P | 1996 |
Circannual variations in bear plasma albumin and its opioid-like effects on guinea pig ileum.
Topics: Analgesics; Animals; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hibernation; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Seasons; Serum Albumin; Ursidae | 1996 |
Endogenous opioids in frontal cortex of patients with Down syndrome.
Topics: Aged; Alzheimer Disease; Down Syndrome; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Frontal Lobe; Gene Expression Regulation; Humans; Male; Middle Aged; Protein Precursors; Radioimmunoassay | 1996 |
The PC12 rat pheochromocytoma cell line expresses the prodynorphin gene and secretes the 8 kDa dynorphin product.
Topics: Adrenal Medulla; Animals; Chromatography, Affinity; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalins; Gene Expression; PC12 Cells; Pheochromocytoma; Pituitary Gland; Polymerase Chain Reaction; Protein Precursors; Rats; Sequence Analysis | 1996 |
Orphanin FQ/nociceptin-immunoreactive nerve fibers parallel those containing endogenous opioids in rat spinal cord.
Topics: Amino Acid Sequence; Animals; Dynorphins; Enkephalins; Immunohistochemistry; Male; Molecular Sequence Data; Narcotics; Nerve Fibers; Neurons; Nociceptin; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 1996 |
Effect of long-term haloperidol treatment on striatal neuropeptides: relation to stereotyped behavior.
Topics: Animals; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Dynorphins; Enkephalins; Haloperidol; Male; Neostriatum; Neuropeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Sensitivity and Specificity; Somatostatin; Stereotyped Behavior; Substance P; Time Factors | 1996 |
D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum.
Topics: Animals; Base Sequence; Body Weight; Brain; Cocaine; Corpus Striatum; DNA-Binding Proteins; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Genes, Immediate-Early; Heterozygote; Homozygote; Immediate-Early Proteins; In Situ Hybridization; Mice; Mice, Knockout; Molecular Sequence Data; Oligonucleotide Probes; Organ Size; Proto-Oncogene Proteins c-fos; Receptors, Dopamine D1; RNA, Messenger; Substance P; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 1996 |
Role of kappa opioid receptors in modulating cholinergic twitches in the circular muscle of guinea-pig colon.
Topics: Acetylcholine; Animals; Colon; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Cholinergic; Receptors, Opioid, kappa | 1996 |
Muscarinic receptors regulate striatal neuropeptide gene expression in normal and amphetamine-treated rats.
Topics: Acetylcholine; Amphetamine; Animals; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression Regulation; Male; Muscarinic Agonists; Muscarinic Antagonists; Nerve Tissue Proteins; Neuropeptides; Oxotremorine; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Muscarinic; Scopolamine; Substance P | 1996 |
Pharmacological and neurochemical differences between acute and tardive vacuous chewing movements induced by haloperidol.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Corpus Striatum; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Haloperidol; In Situ Hybridization; Male; Mastication; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 1996 |
Opioid receptor agonists selective for mu and kappa receptors attenuate methamphetamine-induced behavioral sensitization in the mouse.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Stimulants; Drug Tolerance; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Grooming; Injections, Intraventricular; Male; Methamphetamine; Mice; Mice, Inbred Strains; Motor Activity; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior; Time Factors | 1996 |
Co-localization of mu opioid receptor is greater with dynorphin than enkephalin in rat striatum.
Topics: Animals; Caudate Nucleus; Corpus Striatum; Dynorphins; Enkephalins; Male; Neurons; Putamen; Rats; Rats, Wistar; Receptors, Opioid, mu; RNA Probes; RNA, Messenger | 1996 |
Dopamine antagonist and "binge' cocaine effects on rat opioid and dopamine transporter mRNAs.
Topics: Analysis of Variance; Animals; Benzazepines; Brain; Carrier Proteins; Cocaine; DNA Primers; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Dynorphins; Enkephalins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Polymerase Chain Reaction; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; RNA, Messenger; Substance-Related Disorders; Sulpiride; Transcription, Genetic | 1996 |
Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Diprenorphine; Dogs; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Myocardium; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Sarcolemma; Virulence Factors, Bordetella | 1996 |
Delayed occurrence of enhanced striatal preprodynorphin gene expression in behaviorally sensitized rats: differential long-term effects of intermittent and chronic morphine administration.
Topics: Animals; Autoradiography; Behavior, Animal; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; Male; Morphine; Motor Activity; Narcotics; Protein Precursors; Rats; Rats, Wistar; Time Factors; Tissue Distribution | 1997 |
Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques.
Topics: Animals; Brain; Cocaine; Dynorphins; Enkephalins; Female; Gene Expression Regulation; Macaca mulatta; Narcotics; Pregnancy; Protein Precursors; RNA, Messenger | 1997 |
Endothelin production links superoxide generation to altered opioid-induced pial artery vasodilation after brain injury in pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arterioles; Brain Injuries; Cerebral Arteries; Dynorphins; Endothelin Receptor Antagonists; Endothelin-1; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Muscle, Smooth, Vascular; Peptides, Cyclic; Pia Mater; Superoxides; Swine; Vasoconstriction; Vasodilation | 1997 |
Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; CHO Cells; Cricetinae; Dynorphins; Enkephalins; Kinetics; Mice; Narcotics; Nociceptin; Nociceptin Receptor; Opioid Peptides; Radioligand Assay; Receptors, Opioid; Recombinant Proteins; Transfection | 1997 |
Brain substrates activated by electroacupuncture (EA) of different frequencies (II): Role of Fos/Jun proteins in EA-induced transcription of preproenkephalin and preprodynorphin genes.
Topics: Animals; Brain; Dynorphins; Electroacupuncture; Enkephalins; Female; In Situ Hybridization; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Transcription, Genetic | 1996 |
Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster. III. Autocrine stimulation of prodynorphin gene expression by dynorphin B.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cardiomyopathy, Hypertrophic; Cell Compartmentation; Cell Nucleus; Cricetinae; Cytosol; Dynorphins; Endorphins; Enkephalins; Enzyme Inhibitors; Gene Expression; Mesocricetus; Myocardium; Protein Kinase C; Protein Precursors; Pyrrolidines; Receptors, Opioid, kappa; Ryanodine; Sarcoplasmic Reticulum | 1997 |
Kainic acid-induced sprouting of dynorphin- and enkephalin-containing mossy fibers in the dentate gyrus of the rat hippocampus.
Topics: Animals; Dentate Gyrus; Dynorphins; Enkephalins; Immunohistochemistry; Injections, Subcutaneous; Kainic Acid; Male; Nerve Fibers; Rats; Rats, Inbred F344; Staining and Labeling | 1997 |
Intrastriatal injection of a muscarinic receptor agonist and antagonist regulates striatal neuropeptide mRNA expression in normal and amphetamine-treated rats.
Topics: Amphetamine; Animals; Behavior, Animal; Corpus Striatum; Dynorphins; Enkephalins; Injections; Male; Muscarinic Agonists; Muscarinic Antagonists; Neuropeptides; Oxotremorine; Protein Precursors; Rats; Rats, Wistar; Reference Values; RNA, Messenger; Scopolamine; Substance P | 1997 |
The Leu-enkephalin-encoding sequence DNA-binding factor (LEF) is the transcription factor YY1.
Topics: Animals; Binding Sites; Cell Nucleus; DNA; DNA-Binding Proteins; Dynorphins; Endorphins; Enkephalin, Leucine; Erythroid-Specific DNA-Binding Factors; Molecular Weight; Oligodeoxyribonucleotides; Protein Conformation; Rats; Rats, Sprague-Dawley; Transcription Factors; YY1 Transcription Factor | 1997 |
URE, an initiator (Inr)-like site, suppresses the promoter of the rat dynorphin gene.
Topics: Animals; CHO Cells; Cricetinae; DNA-Binding Proteins; Dynorphins; Enkephalins; Mutation; Oligodeoxyribonucleotides; Phosphoproteins; Promoter Regions, Genetic; Protein Precursors; Rats; Regulatory Sequences, Nucleic Acid; Suppression, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 1997 |
Enkephalinergic and dynorphinergic neurons in the spinal cord and dorsal root ganglia of the polyarthritic rat - in vivo release and cDNA hybridization studies.
Topics: Animals; Arthritis, Experimental; Blotting, Northern; DNA, Complementary; Dynorphins; Enkephalins; Ganglia, Spinal; In Situ Hybridization; Male; Neurons; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord | 1997 |
Immunohistochemical localization of enkephalin in peripheral sensory axons in the rat.
Topics: Animals; Axons; Dynorphins; Enkephalins; Immunohistochemistry; Male; Neurons, Afferent; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1997 |
Acute methamphetamine-induced zif/268, preprodynorphin, and preproenkephalin mRNA expression in rat striatum depends on activation of NMDA and kainate/AMPA receptors.
Topics: Animals; Corpus Striatum; DNA-Binding Proteins; Dynorphins; Early Growth Response Protein 1; Enkephalins; Excitatory Amino Acid Agonists; Immediate-Early Proteins; Male; Methamphetamine; Nerve Tissue Proteins; Protein Precursors; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stimulation, Chemical; Time Factors; Transcription Factors | 1996 |
Opioids in the nucleus of the solitary tract are involved in feeding in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Male; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
Effects of deoxycorticosterone acetate and diazepam on neuropeptidergic neurons in rat striatum.
Topics: Analysis of Variance; Animals; Appetite; Corpus Striatum; Desoxycorticosterone; Diazepam; Dynorphins; Enkephalins; Male; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium, Dietary; Tachykinins; Transcription, Genetic | 1997 |
Antinociceptive effects of dynorphin peptides in a model of inflammatory pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Dynorphins; Edema; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Foot; Inflammation; Male; Nociceptors; Peptide Fragments; Rats; Rats, Wistar | 1997 |
Levels of dynorphin peptides in the central nervous system and pituitary gland of the spontaneously hypertensive rat.
Topics: Animals; Biomarkers; Brain; Dynorphins; Endorphins; Enkephalins; Hypertension; Immunohistochemistry; Lumbosacral Region; Male; Pituitary Gland; Protein Precursors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spinal Cord | 1997 |
[Met5]enkephalin and delta2-opioid receptors in the spinal cord are involved in the cold water swimming-induced antinociception in the mouse.
Topics: Animals; beta-Endorphin; Cold Temperature; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1997 |
Concurrent elevation of the levels of expression of striatal preproenkephalin and preprodynorphin mRNA in the rat brain by chronic treatment with caffeine.
Topics: Animals; Autoradiography; Caffeine; Central Nervous System Stimulants; Corpus Striatum; DNA Probes; Dynorphins; Enkephalins; Gene Expression; Male; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1997 |
[Met]enkephalin in the spinal cord is involved in the antinociception induced by intracerebroventricularly-administered etorphine in the mouse.
Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Etorphine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain Measurement; Receptors, Opioid, delta; Receptors, sigma; Spinal Cord | 1997 |
Preprodynorphin-, preproenkephalin-, and preprotachykinin-expressing neurons in the rat neostriatum: an analysis by immunocytochemistry and retrograde tracing.
Topics: Amino Acid Sequence; Animals; Dynorphins; Enkephalins; Fluorescent Antibody Technique, Direct; Guinea Pigs; Immunoblotting; Immunoenzyme Techniques; Immunohistochemistry; Male; Molecular Sequence Data; Neostriatum; Neurons; Protein Precursors; Rabbits; Rats; Rats, Wistar; Tachykinins | 1997 |
A comparison between microwave irradiation and decapitation: basal levels of dynorphin and enkephalin and the effect of chronic morphine treatment on dynorphin peptides.
Topics: Animals; Brain Chemistry; Decerebrate State; Dynorphins; Endorphins; Enkephalins; Injections, Subcutaneous; Male; Microwaves; Morphine; Opioid Peptides; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1997 |
Dopamine-mediated gene regulation in the striatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cocaine; Corpus Striatum; Dopamine; Dynorphins; Enkephalins; Gene Expression Regulation; Neurons; Proto-Oncogene Proteins c-fos; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance P; Transcription, Genetic | 1998 |
Drugs of abuse and striatal gene expression.
Topics: Animals; Central Nervous System Stimulants; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dynorphins; Enkephalins; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, Immediate-Early; Glutamic Acid; Neurons; Neuropeptides; Protein Precursors; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance-Related Disorders; Transcription, Genetic | 1998 |
Selective innervation of different target tissues in guinea-pig cranial exocrine glands by sub-populations of parasympathetic and sympathetic neurons.
Topics: Animals; Arteries; Dynorphins; Enkephalins; Exocrine Glands; Female; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Neurons; Neuropeptide Y; Parasympathetic Nervous System; Sympathetic Nervous System; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1997 |
The muscarinic toxin 3 augments neuropeptide mRNA in rat striatum in vivo.
Topics: Amphetamine; Animals; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; In Situ Hybridization, Fluorescence; Intercellular Signaling Peptides and Proteins; Male; Muscarinic Antagonists; Neurotoxins; Peptides; Protein Precursors; Radionuclide Imaging; Rats; Rats, Wistar; RNA, Messenger; Substance P | 1997 |
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum.
Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Differential metabolism of dynorphins in substantia nigra, striatum, and hippocampus.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dynorphins; Endorphins; Enkephalin, Leucine; Hippocampus; Male; Mass Spectrometry; Protein Precursors; Rats; Substantia Nigra; Tissue Distribution | 1997 |
Alterations in behavior and opioid gene expression induced by the novel tropane analog WF-31.
Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Fluoxetine; Gene Expression; Genome; Male; Motor Activity; Protein Precursors; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tropanes | 1997 |
Orphanin FQ has an inhibitory effect on the guinea pig ileum and the mouse vas deferens.
Topics: Animals; CHO Cells; Cricetinae; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle, Smooth; Nociceptin; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Vas Deferens | 1997 |
Neuronal circuitry between the inferior mesenteric ganglion and lower intestine of the dog.
Topics: Animals; Bombesin; Calbindins; Calcitonin Gene-Related Peptide; Cholecystokinin; Colon; Dogs; Dynorphins; Enkephalins; Female; Fluorescent Antibody Technique, Indirect; Ganglia; Male; Mesentery; Nerve Tissue Proteins; Neural Pathways; Neuropeptide Y; Rectum; S100 Calcium Binding Protein G; Substance P; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1997 |
Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Dynorphins; Enkephalins; Gene Expression; Male; Neuropeptides; Pain; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Time Factors | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Opioid gene expression in the developing and adult rat heart.
Topics: Animals; Animals, Newborn; Dynorphins; Enkephalins; Female; Gene Expression Regulation, Developmental; Heart; In Situ Hybridization; Male; Myocardium; Opioid Peptides; Pericardium; Pregnancy; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Repeated administration of cocaine, nicotine and ethanol: effects on preprodynorphin, preprotachykinin A and preproenkephalin mRNA expression in the dorsal and the ventral striatum of the rat.
Topics: Animals; Body Weight; Cocaine; Corpus Striatum; Drug Administration Schedule; Dynorphins; Enkephalins; Ethanol; In Situ Hybridization; Injections, Subcutaneous; Male; Nicotine; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tachykinins | 1998 |
Effects of kappa and delta opioid agonists on activity and thermosensitivity of rat hypothalamic neurons.
Topics: Animals; Dynorphins; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypothalamus; Hypothalamus, Anterior; In Vitro Techniques; Male; Neurons; Preoptic Area; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thermosensing | 1998 |
Metabotropic glutamate receptor agonist increases neuropeptide mRNA expression in rat striatum.
Topics: Animals; Corpus Striatum; Cycloleucine; Dynorphins; Enkephalins; Globus Pallidus; In Situ Hybridization; Male; Microinjections; Neurons; Neuropeptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger; Substance P; Substantia Nigra | 1998 |
[Comparative study on the expression and interaction of oncogene c-fos/c-jun and three opioid genes induced by low and high frequency electroacupuncture].
Topics: Animals; Dynorphins; Electroacupuncture; Enkephalins; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; RNA, Messenger | 1996 |
Phenotypic characterization of neuroleptic-sensitive neurons in the forebrain: contrasting targets of haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine D2 Receptor Antagonists; Dynorphins; Enkephalins; Haloperidol; In Situ Hybridization; Male; Neurons; Oligonucleotide Probes; Organ Specificity; Phenotype; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Transcription, Genetic | 1998 |
Changes in the midbrain-rostral forebrain dopamine circuitry in the cocaine-exposed primate fetal brain.
Topics: Amniotic Fluid; Animals; Body Weight; Brain; Cocaine; Dopamine; Dynorphins; Embryonic and Fetal Development; Enkephalins; Female; Gene Expression Regulation, Developmental; Macaca mulatta; Mesencephalon; Metabolic Clearance Rate; Neurons; Pregnancy; Prosencephalon; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Transcription, Genetic | 1998 |
Dynorphin A(1-8): stability and implications for in vitro opioid activity.
Topics: Animals; Binding, Competitive; Drug Stability; Dynorphins; Enkephalins; Guinea Pigs; Male; Mice; Muscles; Myenteric Plexus; Opioid Peptides; Peptide Fragments; Rats; Receptors, Opioid, kappa; Tumor Cells, Cultured; Vas Deferens | 1998 |
Effects of adrenal steroids on basal ganglia neuropeptide mRNA and tyrosine hydroxylase radioimmunoreactive levels in the adrenalectomized rat.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Basal Ganglia; Cholecystokinin; Corticosterone; Desoxycorticosterone; Dynorphins; Enkephalins; Gene Expression; Male; Neuropeptides; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tachykinins; Tyrosine 3-Monooxygenase | 1998 |
Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats.
Topics: Alcohol Drinking; Animals; Dynorphins; Enkephalins; Gene Expression; Histocytochemistry; In Situ Hybridization; Limbic System; Protein Precursors; Rats; Rats, Inbred Strains; Rats, Inbred WKY; RNA, Messenger; Tissue Distribution | 1998 |
[Effect of opioid peptides on immunomodulation].
Topics: Animals; Cyproheptadine; Dopamine D2 Receptor Antagonists; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Haloperidol; Male; Mice; Mice, Inbred CBA; Neuroimmunomodulation; Pituitary Gland; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Serotonin; Spleen | 1998 |
Glucose stimulation of pancreatic beta-cell lines induces expression and secretion of dynorphin.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Dynorphins; Enkephalins; Glucose; Islets of Langerhans; Male; Molecular Sequence Data; Protein Precursors; Rats; Rats, Inbred Lew; RNA, Messenger | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
Effects of halothane, ketamine and nitrous oxide on dynorphin mRNA expression in dorsal horn neurons after peripheral tissue injury.
Topics: Anesthetics, General; Animals; Dynorphins; Enkephalins; Halothane; In Situ Hybridization; Ketamine; Male; Neuronal Plasticity; Neurons; Nitrous Oxide; Rats; Rats, Sprague-Dawley; RNA, Messenger; Soft Tissue Injuries; Spinal Cord | 1998 |
[2 Hz and 100 Hz electroacupuncture accelerate the expression of genes encoding three opioid peptides in the rat brain].
Topics: Acupuncture Analgesia; Animals; Brain; Dynorphins; Electroacupuncture; Enkephalins; Female; Gene Expression; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Wistar | 1997 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Regulation of mu binding sites after chronic administration of antibodies directed against specific anti-opiate peptides.
Topics: alpha-MSH; Animals; Antibodies, Anti-Idiotypic; Binding Sites; Brain Chemistry; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epitopes; Immunoglobulin G; Injections, Intraventricular; Iodine Radioisotopes; Male; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
A heroin-, but not a cocaine-expecting, self-administration state preferentially alters endogenous brain peptides.
Topics: Animals; Behavior, Animal; Brain; Cocaine; Dynorphins; Enkephalins; Heroin; Injections, Intravenous; Male; Neuropeptides; Radioimmunoassay; Rats; Rats, Wistar; Self Administration; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1999 |
Methamphetamine alters prodynorphin gene expression and dynorphin A levels in rat hypothalamus.
Topics: Animals; Brain; Dynorphins; Enkephalins; Gene Expression Regulation; Hippocampus; Hypothalamus; Male; Methamphetamine; Protein Precursors; Rats; Rats, Sprague-Dawley; Substance-Related Disorders; Time Factors; Visual Cortex | 1999 |
Dynorphin A processing enzyme: tissue distribution, isolation, and characterization.
Topics: Amino Acid Sequence; Animals; Cattle; Dynorphins; Enkephalins; Metalloendopeptidases; Molecular Sequence Data; Neprilysin; Organ Specificity; Protein Precursors; Rats; Rats, Sprague-Dawley | 1999 |
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus | 1999 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain.
Topics: Animals; Brain Chemistry; Dynorphins; Enkephalins; Gene Expression; Male; Morphine; Narcotics; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, kappa; RNA, Messenger | 1999 |
Orofacial deep and cutaneous tissue inflammation differentially upregulates preprodynorphin mRNA in the trigeminal and paratrigeminal nuclei of the rat.
Topics: Animals; Dynorphins; Enkephalins; Freund's Adjuvant; Gene Expression; Hyperalgesia; In Situ Hybridization; Male; Neurogenic Inflammation; Neurons, Afferent; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Skin; Temporomandibular Joint; Temporomandibular Joint Disorders; Trigeminal Nuclei | 1999 |
Antianalgesic action of dynorphin A mediated by spinal cholecystokinin.
Topics: Analgesia; Analgesics; Animals; Antibodies; Cholecystokinin; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Injections, Spinal; Male; Meglumine; Mice; Morphine; Proglumide; Receptors, Cholecystokinin; Receptors, Opioid, delta; Spinal Cord | 1999 |
Descending modulation of opioid-containing nociceptive neurons in rats with peripheral inflammation and hyperalgesia.
Topics: Animals; Blotting, Northern; Calcitonin Gene-Related Peptide; Colchicine; Denervation; Dynorphins; Enkephalins; Freund's Adjuvant; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Male; Neurons, Afferent; Nociceptors; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Tachykinins | 1999 |
The hippocampal opioidergic system: a comparative immunocytochemical study in four rodents.
Topics: Animals; Cricetinae; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Guinea Pigs; Hippocampus; Immunohistochemistry; Male; Mesocricetus; Mice; Nerve Fibers; Neurons; Pyramidal Cells; Rats; Species Specificity | 1998 |
[Effects of long-term and high intensity exercise on plasma beta-endorphin, dynorphin A1-13, leucine-enkephalin and lactate in rats].
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Dynorphins; Enkephalin, Leucine; Lactic Acid; Male; Peptide Fragments; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley | 1997 |
Activation of spinal opioid receptors contributes to hypotension after hemorrhage in conscious rats.
Topics: Animals; Blood Pressure; Consciousness; Dynorphins; Endorphins; Enkephalin, Leucine; Heart Rate; Hemorrhage; Hypotension; Male; Naloxone; Narcotic Antagonists; Neural Inhibition; Rats; Rats, Inbred WKY; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Sympathetic Nervous System | 1999 |
Opioid peptides inhibit the action of oestradiol on human myometrial cells in culture.
Topics: Adult; Cell Division; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Estradiol; Female; Humans; Inhibitory Concentration 50; Muscle, Smooth; Myometrium; Naloxone; Narcotic Antagonists; Progesterone | 1999 |
Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates.
Topics: Animals; Animals, Newborn; Brain Diseases; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; Glutamate Decarboxylase; Isoenzymes; Neurons; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution | 1999 |
Opioid agonist modulation of cytoplasmic free Ca2+ level in concanavalin A-stimulated mouse lymphocytes.
Topics: Animals; Calcium; Concanavalin A; Cytoplasm; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred CBA; Peptide Fragments; Receptors, Opioid | 1999 |
Dopamine-opiate interaction in the regulation of neostriatal and pallidal neuronal activity as assessed by opioid precursor peptides and glutamate decarboxylase messenger RNA expression.
Topics: Animals; Dopamine; Dopamine Antagonists; Dynorphins; Enkephalins; Globus Pallidus; Glutamate Decarboxylase; Haloperidol; Male; Naloxone; Narcotic Antagonists; Neostriatum; Neurons; Opioid Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, mu; RNA, Messenger | 1999 |
Suppression of serotonin hyperinnervation does not alter the dysregulatory influences of dopamine depletion on striatal neuropeptide gene expression in rodent neonates.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Chromatography, High Pressure Liquid; Corpus Striatum; Denervation; Dopamine; Dynorphins; Enkephalins; Gene Expression Regulation; In Situ Hybridization; Neuropeptides; Nucleic Acid Hybridization; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Serotonin; Tachykinins | 1999 |
Differential effects of intrastriatally infused fully and endcap phosphorothioate antisense oligonucleotides on morphology, histochemistry and prodynorphin expression in rat brain.
Topics: Acetylcholinesterase; Animals; Brain; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression Regulation; Infusions, Parenteral; Neurons; Neuropeptide Y; Oligodeoxyribonucleotides, Antisense; Protein Precursors; Rats; RNA, Messenger; Thionucleotides; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2000 |
Correlates of deoxycorticosterone-induced salt appetite behavior and basal ganglia neurochemistry.
Topics: Animals; Appetite; Basal Ganglia; Carrier Proteins; Cocaine; Desoxycorticosterone; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Gene Expression Regulation; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium, Dietary; Transcription, Genetic; Tyrosine 3-Monooxygenase | 1999 |
Late direct and transneuronal effects in mice with targeted expression of a toxin gene to D1 dopamine receptor neurons.
Topics: Animals; Animals, Newborn; Autoradiography; Carrier Proteins; Diphtheria Toxin; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Gene Expression; Gene Targeting; Kanamycin Kinase; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Motor Activity; Nerve Tissue Proteins; Neurons; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Muscarinic; RNA, Messenger; Substance P | 2000 |
Immunoneutralization of endogenous opioid peptides prevents the suckling-induced prolactin increase and the inhibition of tuberoinfundibular dopaminergic neurons.
Topics: Animals; Animals, Suckling; Arcuate Nucleus of Hypothalamus; Cross Reactions; Dopamine; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Immunoglobulin G; Lactation; Male; Neurons; Neutralization Tests; Opioid Peptides; Pituitary Gland; Prolactin; Rats; Rats, Sprague-Dawley | 2000 |
ARC POMC mRNA and PVN alpha-MSH are lower in obese relative to lean zucker rats.
Topics: alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Blood Glucose; Dynorphins; Energy Metabolism; Enkephalins; Feeding Behavior; Gene Expression; Insulin; Leptin; Male; Melanocytes; Neuropeptide Y; Obesity; Paraventricular Hypothalamic Nucleus; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Zucker; RNA, Messenger | 2000 |
Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
Topics: Age Factors; Amnesia; Analgesics, Opioid; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Chickens; Chloramphenicol; Conditioning, Psychological; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Female; Male; Memory; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Protein Synthesis Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 2000 |
A group of cortical interneurons expressing mu-opioid receptor-like immunoreactivity: a double immunofluorescence study in the rat cerebral cortex.
Topics: Animals; Calbindin 2; Calbindins; Cerebral Cortex; Cholecystokinin; Choline O-Acetyltransferase; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; gamma-Aminobutyric Acid; Interneurons; Neuropeptide Y; Nitric Oxide Synthase; Parvalbumins; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, mu; S100 Calcium Binding Protein G; Somatostatin; Vasoactive Intestinal Peptide | 2000 |
Interleukin-2: structural and biological relatedness to opioid peptides.
Topics: Analgesics; Animals; Antibodies; Antibodies, Monoclonal; beta-Endorphin; Brain Chemistry; Cross Reactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-2; Male; Mutagenesis, Site-Directed; Neuroimmunomodulation; Nociceptors; Opioid Peptides; Pain Threshold; Peptide Fragments; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Structure-Activity Relationship | 2000 |
Role of NOC/oFQ in impaired opioid-induced pial artery dilation following brain injury.
Topics: Animals; Brain Injuries; Cerebral Arteries; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Nociceptin; Opioid Peptides; Pia Mater; Swine; Vasodilation | 2000 |
Opioid peptide messenger RNA expression is increased at spinal and supraspinal levels following excitotoxic spinal cord injury.
Topics: Animals; Dynorphins; Enkephalins; Excitatory Amino Acid Agonists; Lumbar Vertebrae; Male; Opioid Peptides; Protein Precursors; Quisqualic Acid; Rats; Rats, Long-Evans; RNA, Messenger; Spinal Cord Injuries; Thoracic Vertebrae | 2000 |
Opioid peptide gene expression primes cardiogenesis in embryonal pluripotent stem cells.
Topics: Animals; Autocrine Communication; Cell Differentiation; Dimethyl Sulfoxide; DNA-Binding Proteins; Dynorphins; Endorphins; Enkephalins; Fetal Heart; Fetal Proteins; GATA4 Transcription Factor; Gene Expression Regulation, Developmental; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Mice; Oligonucleotides, Antisense; Opioid Peptides; Protein Precursors; Recombinant Fusion Proteins; RNA, Messenger; Stem Cells; Thionucleotides; Transcription Factors; Transfection; Xenopus Proteins; Zinc Fingers | 2000 |
Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Gene Expression; In Situ Hybridization; Male; Morphine; Naloxone; Narcotic Antagonists; Neostriatum; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Running; Species Specificity; Substance P | 2000 |
Involvement of dynorphin in immobilization stress-induced antinociception in the mouse.
Topics: Animals; beta-Endorphin; Cerebral Ventricles; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Reaction Time; Restraint, Physical; Stress, Psychological | 2000 |
Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists.
Topics: Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Motor Cortex; Myocardial Ischemia; Peptide Fragments; Receptors, Opioid | 2000 |
Contrasting patterns and cellular specificity of transcriptional regulation of the nuclear receptor nerve growth factor-inducible B by haloperidol and clozapine in the rat forebrain.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; DNA-Binding Proteins; Drug Administration Schedule; Dynorphins; Enkephalins; Gene Expression Regulation; Haloperidol; In Situ Hybridization; Male; Neurons; Neurotensin; Nuclear Receptor Subfamily 4, Group A, Member 1; Nucleus Accumbens; Organ Specificity; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors | 2000 |
Dopamine control of striatal gene expression during development: relevance to knockout mice for the dopamine transporter.
Topics: Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Female; Gene Expression Regulation, Developmental; Gestational Age; In Situ Hybridization; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Pregnancy; Protein Precursors; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Substance P; Tyrosine 3-Monooxygenase | 2000 |
Cocaine and methamphetamine differentially affect opioid peptide mRNA expression in the striatum.
Topics: Animals; Autoradiography; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; In Situ Hybridization; Male; Methamphetamine; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2000 |
Basal levels and alcohol-induced changes in nociceptin/orphanin FQ, dynorphin, and enkephalin levels in C57BL/6J mice.
Topics: Alcohol Drinking; Alcohol-Induced Disorders, Nervous System; Animals; Brain; Brain Chemistry; Drug Administration Schedule; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nociceptin; Opioid Peptides; Pituitary Gland; Self Administration | 2000 |
Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P, and preproenkephalin mRNA expression in rat dorsal striatum.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; Neostriatum; Neurons; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; RNA, Messenger; Substance P; Time Factors | 2001 |
Effects of brain-derived neurotrophic factor and neurotrophin-3 on expression of mRNAs encoding c-Fos, neuropeptides and glutamic acid decarboxylase in cultured spinal neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Dynorphins; Enkephalins; Gene Expression Regulation; Genes, fos; Glutamate Decarboxylase; Neurons; Neuropeptide Y; Neuropeptides; Neurotrophin 3; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord | 2000 |
Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Corpus Striatum; Cycloleucine; Dynorphins; Enkephalins; Gene Expression; Immunohistochemistry; In Situ Hybridization; Methoxyhydroxyphenylglycol; Neurons; Neuroprotective Agents; Nucleus Accumbens; Phenotype; Protein Precursors; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; RNA, Messenger | 2001 |
Intrastriatal GABA(A) receptor blockade does not alter dopamine D(1)/D(2) receptor interactions in the intact rat striatum.
Topics: Animals; Behavior, Animal; Benzazepines; Bicuculline; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Drug Administration Schedule; Dynorphins; Enkephalins; GABA Antagonists; GABA-A Receptor Antagonists; Gene Expression; In Situ Hybridization; Injections, Subcutaneous; Male; Microinjections; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, GABA-A; RNA, Messenger; Salicylamides | 2001 |
Spinal and supraspinal changes in opioid mRNA expression are related to the onset of pain behaviors following excitotoxic spinal cord injury.
Topics: Animals; Brain; Dynorphins; Enkephalins; Excitatory Amino Acid Agonists; Gene Expression; Grooming; Male; Opioid Peptides; Pain; Protein Precursors; Quisqualic Acid; Rats; Rats, Long-Evans; RNA, Messenger; Spinal Cord; Spinal Cord Injuries | 2001 |
Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine; Dynorphins; Enkephalins; In Situ Hybridization; Locomotion; Male; Microdialysis; Neurons; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Tyrosine Transaminase | 2001 |
Cellular mRNA expression of the transcription factor NGFI-B suggests a gene regulatory role in striatal opiate-peptide neurons.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; DNA-Binding Proteins; Dynorphins; Enkephalins; Gene Expression Regulation; In Situ Hybridization; Interneurons; Male; Nuclear Receptor Subfamily 4, Group A, Member 1; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Transcription Factors | 2001 |
Antisera against endogenous opioids increase the nocifensive response to formalin: demonstration of inhibitory beta-endorphinergic control.
Topics: Animals; beta-Endorphin; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Formaldehyde; Immune Sera; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Nociceptors; Opioid Peptides; Pain | 2001 |
The role of kainic acid/AMPA and metabotropic glutamate receptors in the regulation of opioid mRNA expression and the onset of pain-related behavior following excitotoxic spinal cord injury.
Topics: Animals; Behavior, Animal; Dynorphins; Enkephalins; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Grooming; Indans; Male; Nerve Degeneration; Neurons; Neurotoxins; Opioid Peptides; Pain; Pain Measurement; Protein Precursors; Quinoxalines; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; RNA, Messenger; Spinal Cord; Spinal Cord Injuries | 2001 |
Endogenous opioids and oligodendroglial function: possible autocrine/paracrine effects on cell survival and development.
Topics: Aging; Animals; Animals, Newborn; Autocrine Communication; Brain; Cell Differentiation; Cell Survival; Cells, Cultured; Dynorphins; Enkephalins; Immunohistochemistry; Mice; Narcotic Antagonists; Narcotics; Oligodendroglia; Opioid Peptides; Paracrine Communication; Protein Precursors; Receptors, Opioid, kappa; Stem Cells | 2001 |
Alterations in GAD67, dynorphin and enkephalin mRNA in striatal output neurons following priming in the 6-OHDA model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine Agonists; Down-Regulation; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Gene Expression; Glutamate Decarboxylase; Isoenzymes; Levodopa; Neostriatum; Neurons; Oxidopamine; Parkinsonian Disorders; Quinpirole; Rats; RNA, Messenger; Sympatholytics; Up-Regulation | 2001 |
Effects of microiontophoretically-applied opioid peptides on Purkinje cells in the cat cerebellum.
Topics: Action Potentials; Animals; Cats; Cerebellum; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Iontophoresis; Male; Morphine; Opioid Peptides; Peptide Fragments; Purkinje Cells | 2000 |
Alterations in central preproenkephalin mRNA expression after chronic free-choice ethanol consumption by fawn-hooded rats.
Topics: Amygdala; Animals; Brain; Dynorphins; Enkephalins; Ethanol; Gene Expression; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Olfactory Pathways; Protein Precursors; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Self Administration | 2001 |
Cytotoxic effects of dynorphins through nonopioid intracellular mechanisms.
Topics: Apoptosis; Cation Exchange Resins; Cell Compartmentation; Cell Survival; Central Nervous System; Cytoplasm; Cytotoxins; Dynorphins; Enkephalins; Immunohistochemistry; Lipids; Naloxone; Narcotic Antagonists; Nerve Degeneration; Peptide Fragments; Protein Precursors; Protein Structure, Tertiary; Receptors, Opioid; Receptors, Opioid, kappa; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Kappa opioid receptor stimulation decreases amphetamine-induced behavior and neuropeptide mRNA expression in the striatum.
Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Central Nervous System Stimulants; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; In Situ Hybridization; Male; Neuropeptides; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger; Stimulation, Chemical; Substance P | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Dronabinol; Dynorphins; Enkephalins; Female; Gene Targeting; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Morphine; Motivation; Motor Activity; Narcotics; Pain Measurement; Protein Precursors; Receptors, Opioid, kappa; Spatial Behavior; Substance-Related Disorders | 2001 |
MK-801 alters the effects of priming with L-DOPA on dopamine D1 receptor-induced changes in neuropeptide mRNA levels in the rat striatal output neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Dopamine Agonists; Drug Interactions; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Excitatory Amino Acid Antagonists; Immunohistochemistry; Levodopa; Male; Motor Activity; Neostriatum; Neurons; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tachykinins; Tyrosine 3-Monooxygenase | 2002 |
A novel tandem quadrupole mass spectrometer allowing gaseous collisional activation and surface induced dissociation.
Topics: Amino Acid Sequence; Angiotensinogen; Bradykinin; Cysteine; Dynorphins; Enkephalin, Leucine; Fibrinopeptide A; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Peptide Fragments; Reproducibility of Results; Sensitivity and Specificity; Thermodynamics | 2001 |
Roles of endogenous opioid peptides in modulation of nocifensive response to formalin.
Topics: Animals; Antibodies, Blocking; Dynorphins; Endorphins; Enkephalins; Formaldehyde; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Somatostatin; Spinal Cord | 2002 |
Impaired preprodynorphin, but not preproenkephalin, mRNA induction in the striatum of mGluR1 mutant mice in response to acute administration of the full dopamine D(1) agonist SKF-82958.
Topics: Animals; Benzazepines; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Gene Expression Regulation; Injections, Intraperitoneal; Male; Mice; Mice, Knockout; Nucleus Accumbens; Protein Precursors; Putamen; Receptors, Dopamine D1; Receptors, Metabotropic Glutamate; RNA, Messenger; Up-Regulation | 2002 |
Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats.
Topics: Animals; Corpus Striatum; Denervation; Dopamine; Dopamine Agents; Dynorphins; Enkephalins; Glutamate Decarboxylase; Isoenzymes; Levodopa; Male; Neuroprotective Agents; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Triazoles | 2002 |
A simplified method for combined immunohistochemistry and in-situ hybridization in fresh-frozen, cryocut mouse brain sections.
Topics: Animals; Brain; Brain Chemistry; Cyclic AMP Response Element-Binding Protein; Dynorphins; Enkephalins; Frozen Sections; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Transgenic; Neurons; Oligonucleotide Probes; RNA, Messenger; Tissue Fixation | 2002 |
Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice.
Topics: Animals; Cocaine; Corpus Striatum; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamo-Hypophyseal System; Male; Medulla Oblongata; Mice; Mice, Knockout; Pituitary-Adrenal System; Pons; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, mu; RNA, Messenger | 2002 |
Effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Dynorphins; Enkephalins; Female; Luteinizing Hormone; Naltrexone; Ovulation; Peptide Fragments; Proestrus; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
Preprodynorphin-, preproenkephalin-, preprotachykinin A- and preprotachykinin B-immunoreactive neurons in the accumbens nucleus and olfactory tubercle: double-immunofluorescence analysis.
Topics: Animals; Dynorphins; Enkephalins; Fluorescent Antibody Technique; Immunohistochemistry; Neurokinin B; Neurons; Nucleus Accumbens; Olfactory Pathways; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Tachykinins | 2002 |
Delta FosB regulates wheel running.
Topics: Animals; Behavior, Animal; Caudate Nucleus; Cell Count; Corpus Striatum; Doxycycline; Dynorphins; Enkephalins; Gene Expression; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Inbred Lew; Reward; RNA, Messenger | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Key role for enkephalinergic tone in cortico-striatal-thalamic function.
Topics: Animals; Astrocytes; Borna Disease; Borna disease virus; Cells, Cultured; Dynorphins; Enkephalins; Gene Expression; Genes, fos; Humans; Male; Neuroblastoma; Protein Precursors; Putamen; Rats; Rats, Inbred Lew; Receptors, Dopamine D2; Tumor Cells, Cultured | 2002 |
Further studies on possible dynorphin involvement in the ovulatory luteinizing hormone surge in the proestrous rat.
Topics: Animals; Antibodies; Dynorphins; Enkephalins; Female; Luteinizing Hormone; Ovulation; Peptide Fragments; Perfusion; Preoptic Area; Proestrus; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger | 2002 |
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cyclic AMP Response Element-Binding Protein; Depression; Dynorphins; Enkephalins; Helplessness, Learned; Immunohistochemistry; Male; Mice; Mice, Transgenic; Mutation; Naltrexone; Nucleus Accumbens; Prosencephalon; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
In situ hybridization with isotopic riboprobes for detection of striatal neuropeptide mRNA expression after dopamine stimulant administration.
Topics: Animals; Antisense Elements (Genetics); Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Humans; In Situ Hybridization; Protein Precursors; Rats; RNA Probes; RNA, Messenger | 2003 |
[Study on the relationship between endogenous opioid peptides and fetal distress].
Topics: Adult; beta-Endorphin; Dynorphins; Enkephalin, Leucine; Female; Fetal Blood; Fetal Distress; Humans; Opioid Peptides; Pregnancy | 2002 |
Protein kinase C signaling transduces endorphin-primed cardiogenesis in GTR1 embryonic stem cells.
Topics: Animals; Cell Differentiation; Cell Line; Cell Nucleus; Dynorphins; Embryo, Mammalian; Embryo, Nonmammalian; Endorphins; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Heart; Isoenzymes; Myocytes, Cardiac; Myosin Heavy Chains; Narcotic Antagonists; Protein Kinase C; Protein Precursors; Receptors, Opioid, kappa; RNA, Messenger; Signal Transduction; Stem Cells | 2003 |
Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells.
Topics: Animals; Cell Differentiation; Cell Line; Cell Lineage; Cell Nucleus; DNA-Binding Proteins; Dynorphins; Embryo, Mammalian; Embryo, Nonmammalian; Endorphins; Enkephalins; Enzyme Activation; GATA4 Transcription Factor; Gene Expression Regulation, Developmental; Heart; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Myocytes, Cardiac; Protein Kinase C; Protein Precursors; Receptors, Opioid; RNA, Messenger; Signal Transduction; Stem Cells; Transcription Factors; Transcriptional Activation; Xenopus Proteins | 2003 |
Long-term alteration in bodyweight and food restriction does not affect the gene expression of either preproorexin or prodynorphin in the sheep.
Topics: Animals; Appetite Regulation; Body Weight; Carrier Proteins; Dynorphins; Enkephalins; Feeding Behavior; Female; Food Deprivation; Gene Expression Regulation; Hypothalamus; Intracellular Signaling Peptides and Proteins; Neurons; Neuropeptides; Neurosecretory Systems; Orexins; Ovariectomy; Protein Precursors; RNA, Messenger; Sheep; Time Factors | 2003 |
The regulation of steroidogenesis by opioid peptides in porcine theca cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; Cells, Cultured; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Estradiol; Female; Opioid Peptides; Progesterone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Steroids; Swine; Testosterone; Theca Cells | 2003 |
Developmental changes in the inhibition of cultured rat uterine cell proliferation by opioid peptides.
Topics: Aging; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Epidermal Growth Factor; Estradiol; Female; Inhibitory Concentration 50; Naloxone; Narcotic Antagonists; Opioid Peptides; Ovariectomy; Rats; Rats, Inbred Strains; Rats, Wistar; Uterus | 2003 |
Opioid peptide release in the rat hippocampus after kainic acid-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Disease Progression; Down-Regulation; Dynorphins; Enkephalins; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Opioid Peptides; Rats; Rats, Wistar; Reaction Time; Status Epilepticus | 2003 |
Involvement of mesolimbic structures in short-term sodium depletion: in situ hybridization and ligand-binding analyses.
Topics: Animals; Autoradiography; Corpus Striatum; Desoxycorticosterone; Diuresis; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Drinking; Dynorphins; Enkephalins; Furosemide; In Situ Hybridization; Limbic System; Male; Membrane Glycoproteins; Membrane Transport Proteins; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Nucleus Accumbens; Raclopride; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Sodium Chloride, Dietary; Sodium, Dietary; Thirst; Water | 2003 |
State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Body Weight; Brain; Conditioning, Operant; Dynorphins; Eating; Energy Metabolism; Enkephalins; Feeding Behavior; Female; Homeostasis; Male; Mice; Mice, Knockout; Pro-Opiomelanocortin | 2003 |
Long-term effects of short and long periods of maternal separation on brain opioid peptide levels in male Wistar rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Corticosterone; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Maternal Deprivation; Opioid Peptides; Pituitary Gland; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Time Factors; Ultrasonics | 2003 |
Neurochemical changes in dopamine D1, D3 and D1/D3 receptor knockout mice.
Topics: Animals; Autoradiography; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Protein Binding; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, GABA-A; Receptors, Muscarinic; RNA, Messenger; Substance P; Telencephalon | 2003 |
Chemical organization of projection neurons in the rat accumbens nucleus and olfactory tubercle.
Topics: Animals; Basal Ganglia; Dynorphins; Enkephalins; Fluorescent Antibody Technique; Immunoenzyme Techniques; Immunohistochemistry; Male; Neural Pathways; Neurokinin B; Neurons; Nucleus Accumbens; Olfactory Pathways; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Tachykinins | 2003 |
Effects of c-fos antisense oligodeoxynucleotide on 5-HT-induced upregulation of preprodynorphin, preproenkephalin, and glutamic acid decarboxylase mRNA expression in cultured rat spinal dorsal horn neurons.
Topics: Animals; Cells, Cultured; Dynorphins; Enkephalins; Gene Expression Regulation; Glutamate Decarboxylase; Oligodeoxyribonucleotides, Antisense; Posterior Horn Cells; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Serotonin; Serotonin Antagonists; Up-Regulation | 2003 |
Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation.
Topics: Afferent Pathways; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Dynorphins; Enkephalins; Hyperesthesia; Ligation; Lumbosacral Region; Male; Medulla Oblongata; Microinjections; N-Glycosyl Hydrolases; Nerve Compression Syndromes; Neuralgia; Neuronal Plasticity; Neurotransmitter Agents; Oligopeptides; Opioid Peptides; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Sensory Thresholds; Spinal Cord; Spinal Nerves | 2003 |
Repeated methylphenidate treatment in adolescent rats alters gene regulation in the striatum.
Topics: Anesthetics, Local; Animals; Autoradiography; Cell Count; Central Nervous System Stimulants; Cocaine; Corpus Striatum; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Administration Schedule; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Gene Silencing; Genes, fos; Immediate-Early Proteins; In Situ Hybridization; Male; Methylphenidate; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance P; Transcription Factors | 2003 |
Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice.
Topics: Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Mice; Mice, Knockout; Nociceptin Receptor; Opioid Peptides; Protein Binding; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Up-Regulation | 2003 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats.
Topics: Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Extinction, Psychological; Male; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Recurrence; RNA, Messenger; Self Administration; Time Factors | 2004 |
The influence of opioid peptides on steroidogenesis in porcine granulosa cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Granulosa Cells; Luteinizing Hormone; Opioid Peptides; Ovarian Follicle; Swine | 2004 |
Primary structure of guinea pig preprodynorphin and preproenkephalin mRNAs: multiple transcription initiation sites for preprodynorphin.
Topics: Animals; Base Sequence; Brain; Dynorphins; Enkephalins; Guinea Pigs; Male; Molecular Sequence Data; Pituitary Gland; Protein Precursors; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription Initiation Site | 2004 |
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
Topics: Animals; Astrocytes; Disease Models, Animal; Disease Progression; Drug Tolerance; Dynorphins; Enkephalins; G-Protein-Coupled Receptor Kinase 3; Hyperalgesia; Lumbosacral Region; Mice; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Narcotics; Neuralgia; Neurons; Protein Precursors; Protein Serine-Threonine Kinases; Receptors, Opioid; Receptors, Opioid, kappa; Sciatic Neuropathy; Spinal Cord | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice.
Topics: Animals; Benzodiazepinones; Disease Models, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Gene Expression; Hyperalgesia; Inflammation; Ligation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Phenylurea Compounds; Pro-Opiomelanocortin; Protein Precursors; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Neuropathy; Time Factors | 2004 |
Opioid receptors and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated.
Topics: Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dynorphins; Electric Stimulation; Enkephalins; Extinction, Psychological; Gene Expression Regulation; Hindlimb; Male; Morphine; Motor Activity; Narcotics; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2004 |
Differential mechanisms of antianalgesia induced by endomorphin-1 and endomorphin-2 in the ventral periaqueductal gray of the rat.
Topics: Analgesia; Animals; beta-Endorphin; Cholecystokinin; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Morphine; Naloxone; Oligopeptides; Periaqueductal Gray; Rats; Receptors, Opioid, mu; Substance P | 2005 |
Striatal opioid peptide content in an animal model of spontaneous stereotypic behavior.
Topics: Animals; Basal Ganglia; Cerebral Cortex; Corpus Striatum; Dynorphins; Enkephalin, Leucine; Male; Models, Animal; Neural Pathways; Opioid Peptides; Peromyscus; Stereotyped Behavior | 2005 |
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation.
Topics: Agmatine; Analysis of Variance; Animals; Behavior, Animal; Biguanides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Antagonists; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Nociceptin Receptor; Piperidines; Protein Precursors; Receptors, Opioid; Spinal Cord; Time Factors | 2005 |
The antidepressant effect of running is associated with increased hippocampal cell proliferation.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cell Count; Cell Proliferation; Depression; Disease Models, Animal; Dynorphins; Enkephalins; Freezing Reaction, Cataleptic; Hippocampus; Immunohistochemistry; In Situ Hybridization; Male; Rats; Rats, Inbred Strains; RNA, Messenger; Running; Substance P | 2005 |
The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Blotting, Western; Cyclic AMP Response Element-Binding Protein; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Eating; Enkephalins; Feeding Behavior; Food Deprivation; Gene Expression Regulation; Hypothalamic Hormones; Immunohistochemistry; In Situ Hybridization, Fluorescence; Intracellular Signaling Peptides and Proteins; Melanins; Mice; Mice, Transgenic; Neurons; Neuropeptides; Nucleus Accumbens; Orexin Receptors; Orexins; Pituitary Hormones; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Receptors, Pituitary Hormone; Serine; Swimming; Time Factors | 2005 |
Different responsiveness of striatonigral and striatopallidal neurons to L-DOPA after a subchronic intermittent L-DOPA treatment.
Topics: Analysis of Variance; Animals; Autoradiography; Cell Count; Corpus Striatum; DNA-Binding Proteins; Dopamine Agents; Drug Administration Schedule; Drug Interactions; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Immediate-Early Proteins; In Situ Hybridization; Levodopa; Male; Neural Pathways; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Transcription Factors; Transcriptional Activation | 2005 |
Denervation and repeated L-DOPA induce complex regulatory changes in neurochemical phenotypes of striatal neurons: implication of a dopamine D1-dependent mechanism.
Topics: Animals; Corpus Striatum; Denervation; Disease Models, Animal; DNA-Binding Proteins; Dopamine; Dopamine Antagonists; Dynorphins; Enkephalins; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Levodopa; Male; Neurons; Neurotensin; Nuclear Receptor Subfamily 4, Group A, Member 1; Parkinson Disease; Phenotype; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, Steroid; RNA, Messenger; Transcription Factors; Tyrosine 3-Monooxygenase | 2005 |
Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Dynorphins; Enkephalins; Frontal Lobe; Gene Expression Regulation; Genotype; Hippocampus; Maze Learning; Mice; Mice, Knockout; Protein Precursors; Radioimmunoassay; Reaction Time; Retention, Psychology; Space Perception; Spatial Behavior; Swimming; Time Factors | 2005 |
Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism: effect on the activity of striatal output pathways.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cell Count; Dynorphins; Enkephalins; Globus Pallidus; Immunohistochemistry; In Situ Hybridization; Male; Microinjections; Neostriatum; Neural Pathways; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; RNA, Messenger; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2005 |
Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Depression; Disease Models, Animal; Dynorphins; Enkephalins; Exercise Therapy; Hippocampus; Immunohistochemistry; In Situ Hybridization; Male; Neuropeptide Y; Rats; Rats, Inbred Strains; Running | 2006 |
Reduced kappa-opioid activity in a rat model of cholestasis.
Topics: Animals; Binding, Competitive; Brain; Cholestasis; Dialysis Solutions; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Hypothalamus; Male; Microdialysis; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sulfur Radioisotopes | 2005 |
Lymphocytic ppENKmRNA, MEK-IR, and Dyn-IR in electroacupuncture.
Topics: Animals; Dynorphins; Electroacupuncture; Enkephalin, Methionine; Enkephalins; Immunity, Cellular; Immunohistochemistry; In Situ Hybridization; Lymphocytes; Mice; Mice, Inbred BALB C; RNA, Messenger | 2005 |
A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward.
Topics: Acetylcholine; Animals; Arousal; Dopamine; Dynorphins; Energy Metabolism; Enkephalins; Food; Hypothalamus; Models, Biological; Narcotics; Nucleus Accumbens; Protein Precursors; Rats; Receptors, Opioid, kappa; Reward; RNA, Messenger; Thalamus | 2005 |
Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate-putamen and nucleus accumbens of ad libitum fed and food-restricted rats.
Topics: Animals; Benzazepines; Caudate Nucleus; Dopamine Agonists; Dynorphins; Eating; Enkephalins; Food Deprivation; Gene Expression Regulation; Genes, fos; Injections, Intraventricular; Male; Neuropeptides; Nucleus Accumbens; Protein Precursors; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reward; RNA, Messenger; Signal Transduction; Stimulation, Chemical; Tachykinins | 2005 |
Chronic and acute effects of 3,4-methylenedioxy-N-methylamphetamine ('Ecstasy') administration on the dynorphinergic system in the rat brain.
Topics: Animals; Blotting, Northern; Brain; Dynorphins; Enkephalins; Gene Expression; Hallucinogens; Male; N-Methyl-3,4-methylenedioxyamphetamine; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2006 |
Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Hot Temperature; Male; Memory; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Pain Measurement; Protein Precursors; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2006 |
Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Male; Mice; Mice, Knockout; Morpholines; Naltrexone; Naphthalenes; Protein Precursors; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Self Administration | 2006 |
Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing acupuncture analgesia in the rat.
Topics: Acupuncture Analgesia; Animals; Arginine Vasopressin; Dynorphins; Electroacupuncture; Enkephalin, Leucine; Glutamic Acid; Injections, Intraventricular; Male; Microinjections; Naloxone; Narcotic Antagonists; Neurons; Opioid Peptides; Oxytocin; Pain Threshold; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2006 |
Gene expression regulation following behavioral sensitization to cocaine in transgenic mice lacking the glucocorticoid receptor in the brain.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cocaine; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Gene Expression Regulation; GluK2 Kainate Receptor; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Transgenic; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Glucocorticoid; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance P; Synaptic Transmission | 2006 |
Motor-skill learning-associated gene regulation in the striatum: effects of cocaine.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Dopamine; Dynorphins; Enkephalins; Gene Expression Regulation; Learning; Male; Motor Activity; Motor Skills; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Up-Regulation | 2006 |
Kappa opioid control of seizures produced by a virus in an animal model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blotting, Northern; Borna Disease; Cell Survival; Disease Models, Animal; Dynorphins; Electroencephalography; Encephalitis, Viral; Enkephalins; Hippocampus; Male; Naloxone; Narcotic Antagonists; Neurons; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa; Seizures | 2006 |
Reduced ethanol response in the alcohol-preferring RHA rats and neuropeptide mRNAs in relevant structures.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Autoradiography; Avoidance Learning; Behavior, Animal; Central Nervous System Depressants; Cholecystokinin; Dynorphins; Enkephalins; Ethanol; Exploratory Behavior; Gene Expression; In Situ Hybridization; Male; Neuropeptides; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 2006 |
Extracellular signal-regulated mitogen-activated protein kinase inhibitors decrease amphetamine-induced behavior and neuropeptide gene expression in the striatum.
Topics: Aminoacetonitrile; Amphetamine; Amphetamine-Related Disorders; Animals; Butadienes; Corpus Striatum; Disease Models, Animal; Dynorphins; Enkephalins; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Male; MAP Kinase Signaling System; Motor Activity; Neuropeptides; Nitriles; Phosphorylation; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2006 |
Only arginine vasopressin, not oxytocin and endogenous opiate peptides, in hypothalamic paraventricular nucleus play a role in acupuncture analgesia in the rat.
Topics: Acupuncture Analgesia; Afferent Pathways; Animals; Arginine Vasopressin; beta-Endorphin; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Extracellular Fluid; Hypothalamo-Hypophyseal System; Immunohistochemistry; Male; Neurons; Opioid Peptides; Oxytocin; Pain; Paraventricular Hypothalamic Nucleus; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Up-Regulation | 2006 |
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Corpus Striatum; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Exploratory Behavior; Male; Mice; Mice, Knockout; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Receptor, Adenosine A2A; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome | 2006 |
Reversion of levodopa-induced motor fluctuations by the A2A antagonist CSC is associated with an increase in striatal preprodynorphin mRNA expression in 6-OHDA-lesioned rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic Agents; Animals; Caffeine; Corpus Striatum; Dynorphins; Dyskinesias; Enkephalins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger | 2006 |
Dopamine D1 receptors have subcellular distributions conducive to interactions with prodynorphin in the rat nucleus accumbens shell.
Topics: Animals; Axons; Blotting, Western; Dendrites; Dynorphins; Enkephalins; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Transfection | 2006 |
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cell Line; Cell Nucleus; DNA; Dynorphins; Electrophoretic Mobility Shift Assay; Enkephalins; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Insulin-Secreting Cells; Islets of Langerhans; Kv Channel-Interacting Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Binding; Protein Precursors; Receptors, Opioid, kappa; Repressor Proteins | 2006 |
Opioid peptides and receptors in joint tissues: study in the rat.
Topics: Analgesics, Opioid; Animals; Brain; Dextrorphan; Dynorphins; Enkephalins; Joints; Levorphanol; Microscopy, Fluorescence; Naloxone; Periosteum; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Opioid; Stifle; Synovial Membrane; Tritium | 2006 |
CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression.
Topics: Animals; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; Mice; Mice, Knockout; Opioid Peptides; Piperidines; Protein Precursors; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Receptors, Dopamine D4; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger | 2006 |
Nicotine modulation of stress-related peptide neurons.
Topics: Amygdala; Animals; Brain; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Hypothalamo-Hypophyseal System; Male; Neurons; Neuropeptides; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Physiological; Up-Regulation | 2006 |
The existence of opioid receptors in the cochlea of guinea pigs.
Topics: Animals; Cochlea; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Immunohistochemistry; Male; Microscopy, Confocal; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptophysin | 2006 |
Influence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, L-ENK, DYN A1-13.
Topics: Animals; Body Weight; Brain Chemistry; Dynorphins; Enkephalin, Leucine; Lactic Acid; Male; Neuropeptide Y; Peptide Fragments; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxymetopon and oxycodone-6-oxime.
Topics: Animals; Blotting, Northern; Brain; Drug Tolerance; Dynorphins; Enkephalins; Gene Expression; Male; Morphine Derivatives; Narcotics; Oxycodone; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2006 |
Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood.
Topics: Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Cannabis; Conditioning, Operant; Dynorphins; Enkephalins; Female; Guanosine 5'-O-(3-Thiotriphosphate); Heroin Dependence; In Situ Hybridization; Limbic System; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Protein Precursors; Rats; Rats, Long-Evans; Reaction Time | 2007 |
Tandem parallel fragmentation of peptides for mass spectrometry.
Topics: Dynorphins; Enkephalins; Fibrinopeptide B; Mass Spectrometry; Peptides; Sequence Analysis, Protein; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tumor Necrosis Factor-alpha | 2006 |
Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS.
Topics: Animals; Benzeneacetamides; Blotting, Northern; Central Nervous System; Cocaine; Dynorphins; Enkephalins; Fluoxetine; Hippocampus; Hypothalamus; Male; Neostriatum; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA Probes; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin | 2007 |
Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: relationship with circulating triglycerides.
Topics: Alcohol Drinking; Animals; Central Nervous System Depressants; Dietary Fats; Dynorphins; Enkephalins; Ethanol; Galanin; Gene Expression Regulation; Hypothalamus; Insulin; Leptin; Male; Opioid Peptides; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides | 2007 |
Dietary fat stimulates endogenous enkephalin and dynorphin in the paraventricular nucleus: role of circulating triglycerides.
Topics: Animals; Diet, Atherogenic; Diet, Fat-Restricted; Dietary Fats; Dynorphins; Energy Intake; Enkephalins; In Situ Hybridization; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Taste; Time Factors; Triglycerides | 2007 |
Dynorphin peptides differentially regulate the human kappa opioid receptor.
Topics: Animals; Binding, Competitive; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Down-Regulation; Dynorphins; Electrophoresis, Polyacrylamide Gel; Endorphins; Enkephalins; Flow Cytometry; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Peptides; Protease Inhibitors; Protein Precursors; Receptors, Opioid, kappa | 2007 |
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Corpus Striatum; Dynorphins; Enkephalins; Glutamate Decarboxylase; Isoenzymes; Levodopa; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tacrine; Tremor; Triazoles | 2007 |
Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson's disease.
Topics: Afferent Pathways; Animals; Antiparkinson Agents; Aphakia; Corpus Striatum; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Levodopa; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Parkinsonian Disorders; Protein Precursors; Proto-Oncogene Proteins c-fos; Substantia Nigra | 2007 |
Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat.
Topics: Animals; Cold Temperature; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Immunochemistry; Immunohistochemistry; Injections, Spinal; Male; Nicotine; Nicotinic Agonists; Pain Measurement; Pain Threshold; Physical Stimulation; Pressure; Protein Precursors; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors.
Topics: Animals; Benzazepines; Cell Count; Denervation; Dopamine Agents; Dopamine Antagonists; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Enzyme Activation; Female; Fluorescent Antibody Technique; Immunohistochemistry; In Situ Hybridization; Levodopa; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neostriatum; Neurons, Efferent; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 2007 |
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2007 |
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger | 2008 |
Regional adaptations in PSD-95, NGFI-A and secretogranin gene transcripts related to vulnerability to behavioral sensitization to amphetamine in the Roman rat strains.
Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Chromogranins; Disks Large Homolog 4 Protein; Dynorphins; Early Growth Response Protein 1; Enkephalins; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Motor Activity; Nucleus Accumbens; Oligodeoxyribonucleotides; Protein Precursors; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Species Specificity | 2008 |
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Conditioning, Operant; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Odorants; Phosphorylation; Protein Precursors; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Urocortins | 2008 |
Striatal output markers do not alter in response to circling behaviour in 6-OHDA lesioned rats produced by acute or chronic administration of the monoamine uptake inhibitor BTS 74 398.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Chlorobenzenes; Corpus Striatum; Cyclobutanes; Dynorphins; Enkephalins; Gene Expression; In Situ Hybridization; Levodopa; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; RNA, Messenger; Substance P; Time | 2008 |
Control of hormonal stress reactivity by the endogenous opioid system.
Topics: Adrenocorticotropic Hormone; Amygdala; Analysis of Variance; Animals; Anxiety; beta-Endorphin; Corticosterone; Dynorphins; Enkephalins; Exploratory Behavior; Hypothermia; Limbic System; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Opioid Peptides; Paraventricular Hypothalamic Nucleus; Protein Precursors; Proto-Oncogene Proteins c-fos; Reflex, Startle; Stress, Psychological; Time Factors | 2008 |
Dynorphin and prodynorphin mRNA changes in the striatum during nicotine withdrawal.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Mapping; Corpus Striatum; Drug Administration Schedule; Dynorphins; Enkephalins; Gene Expression Regulation; Male; Mice; Nicotine; Protein Precursors; Radioimmunoassay; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors | 2008 |
Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Corpus Striatum; Dopamine; Dopamine Agonists; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Indoles; Male; Motor Activity; Neural Pathways; Opioid Peptides; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger | 2008 |
Detection of a novel immunoreactive endomorphin 2-like peptide in rat brain extracts.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Brain; Chromatography, High Pressure Liquid; Dynorphins; Enkephalins; Immune Sera; Male; Mice; Narcotic Antagonists; Oligopeptides; Peptides; Rabbits; Radioimmunoassay; Rats; Rats, Wistar | 2008 |
Noradrenergic and opioidergic alterations in neuropathy in different rat strains.
Topics: Animals; Chronic Disease; Denervation; Disease Models, Animal; Down-Regulation; Dynorphins; Enkephalins; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Ligation; Male; Neurons, Afferent; Norepinephrine; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Protein Precursors; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Opioid, delta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity; Spinal Cord; Tyrosine 3-Monooxygenase | 2008 |
Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes.
Topics: Animals; Antiparkinson Agents; Apomorphine; Brain; Catechols; Corpus Striatum; Dynorphins; Electron Transport Complex IV; Enkephalins; Gene Expression; Glutamate Decarboxylase; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Motor Activity; Nitriles; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D3; RNA, Messenger; Substantia Nigra; Subthalamus | 2008 |
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Brain Stem; Corticosterone; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Exploratory Behavior; Female; Guanidines; Hypothalamus; Male; Maze Learning; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Neuropeptide Y; Neuropeptides; Protein Precursors; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum.
Topics: Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Male; Mice; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Protein Precursors; Putamen; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Time Factors | 2009 |
Lateralization of dynorphin gene expression in the rat striatum.
Topics: Animals; Corpus Striatum; Dynorphins; Enkephalins; Female; Gene Expression; Glutamate Decarboxylase; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2008 |
Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Indoles; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Opioid, delta; Receptors, Opioid, kappa; RNA, Messenger | 2009 |
Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzamides; beta-Endorphin; Blood Pressure; Cricetinae; Cyclic AMP; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypertension; Hypertrophy, Left Ventricular; Myocardial Contraction; Myocardium; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Systole; Ventricular Remodeling | 2009 |
Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off-line to capillary LC with multistage MS.
Topics: Animals; beta-Endorphin; Chromatography, High Pressure Liquid; Corpus Striatum; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Limit of Detection; Male; Microdialysis; Neuropeptides; Oligopeptides; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2009 |
Developmental changes in the mRNA expression of neuropeptides and dopamine and glutamate receptors in neonates and adult rats after ventral hippocampal lesion.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Brain Injuries; Dynorphins; Enkephalins; Female; Gene Expression Regulation, Developmental; Hippocampus; Ibotenic Acid; Male; Neuropeptides; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance P | 2009 |
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors | 2010 |
Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Dynorphins; Electroacupuncture; Enkephalins; Gene Expression Regulation; Male; Morphine; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Peptide Fragments; Peptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Statistics, Nonparametric; Time Factors | 2010 |
Enkephalins, dynorphins, and beta-endorphin in the rat dorsal horn: an immunofluorescence colocalization study.
Topics: Animals; beta-Endorphin; Dynorphins; Enkephalins; Fluorescent Antibody Technique; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Fibers, Unmyelinated; Neural Pathways; Neurons; Neurons, Afferent; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 2009 |
Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats.
Topics: Animals; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Dyskinesias; Electron Transport Complex IV; Enkephalins; Glutamate Decarboxylase; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Neurons; Oxidopamine; Parkinson Disease, Secondary; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Subthalamic Nucleus | 2009 |
Oscillation development for neurotransmitter-related genes in the mouse striatum.
Topics: Animals; Animals, Newborn; Biological Clocks; Cholecystokinin; Circadian Rhythm; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression Regulation, Developmental; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neurotransmitter Agents; Receptors, Dopamine D1; Receptors, Dopamine D2; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Synaptic Transmission; Time Factors; Up-Regulation | 2010 |
Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Dynorphins; Enkephalins; Freund's Adjuvant; Immunohistochemistry; Inflammation; Injections, Spinal; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spinal Cord; Synaptic Transmission | 2010 |
Effect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areas.
Topics: Alcohol Drinking; Amygdala; Animals; Dynorphins; Enkephalins; Ethanol; Hypothalamus; Male; Nucleus Accumbens; Paraventricular Hypothalamic Nucleus; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ventral Tegmental Area | 2010 |
Dynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patients.
Topics: Aged; Biomarkers, Tumor; Bronchi; Carboxypeptidase H; Carcinoma; Dynorphins; Enkephalins; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Lung Neoplasms; Macrophages, Alveolar; Male; Microscopy, Fluorescence; Middle Aged; Neurotransmitter Agents; Proprotein Convertase 1; Proprotein Convertase 2; Protein Precursors; Receptors, Opioid, kappa; Respiratory Mucosa | 2010 |
Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal.
Topics: Animals; Brain; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Hypothalamo-Hypophyseal System; Male; Morphine; Morphine Dependence; Pituitary-Adrenal System; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Stress, Physiological; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 2010 |
Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Caffeine; Corpus Striatum; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Gene Expression Regulation; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidopamine; Parkinson Disease; Protein Precursors; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Messenger; Statistics, Nonparametric; Time Factors | 2011 |
The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia.
Topics: Amphetamine; Animals; Basal Ganglia; Behavior, Animal; Brain; Corpus Striatum; Dopamine; Dopamine Agents; Dynorphins; Enkephalins; Globus Pallidus; Humans; Immunoenzyme Techniques; Male; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia | 2010 |
Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23.
Topics: Cerebellum; Dynorphins; Enkephalins; Female; Glutamate Plasma Membrane Transport Proteins; Humans; Male; Mutation, Missense; Pedigree; Protein Precursors; Purkinje Cells; Spinocerebellar Degenerations | 2010 |
Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration.
Topics: Analgesia; Analgesics, Opioid; Animals; beta-Endorphin; Dynorphins; Enkephalins; Female; Hot Temperature; Mice; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Nociceptors; Opioid Peptides; Pain Measurement; Stress, Psychological; Swimming; Time Factors | 2011 |
Immune response of submissive and aggressive mice under conditions of opioid receptor activation.
Topics: Aggression; Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Immunomodulation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2009 |
[Effects of Chinese herbs on enkephalin mRNA and prodynorphin mRNA gene expression in rat hippocampus with chronic immobilization stress].
Topics: Animals; Drugs, Chinese Herbal; Dynorphins; Enkephalins; Gene Expression; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Stress, Physiological | 2005 |
Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides.
Topics: Animals; beta-Endorphin; Catheterization; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Microinjections; Naloxone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Periaqueductal Gray; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 2011 |
Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain.
Topics: Alcohol Drinking; Alcoholic Intoxication; Amygdala; Animals; Brain; Central Nervous System Depressants; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Ethanol; Gene Expression; Male; Nociceptin; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Reflex, Righting; Substance Withdrawal Syndrome | 2013 |
Changes in dynorphin immunoreactivity but unaltered density of enkephalin immunoreactive neurons in basal ganglia nuclei of genetically dystonic hamsters.
Topics: Animals; Animals, Genetically Modified; Basal Ganglia; Cricetinae; Disease Models, Animal; Dynorphins; Dystonia; Enkephalins; Female; Interneurons; Male; Mesocricetus; Neurons | 2011 |
L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Humans; Levodopa; Mice; Neostriatum; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression.
Topics: alpha-MSH; Amino Acid Sequence; Animals; beta-Endorphin; Cathepsin L; Dynorphins; Endopeptidases; Enkephalins; Gene Knockout Techniques; Humans; Lysosomes; Mice; Mice, Knockout; Neuropeptides; Peptide Hormones; Proprotein Convertases; Protein Precursors; Protein Processing, Post-Translational; Secretory Vesicles | 2011 |
The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction.
Topics: Adaptation, Physiological; Adult; Alcoholism; Analysis of Variance; Animals; Behavior, Addictive; Case-Control Studies; Dynorphins; Enkephalins; Hippocampus; Humans; Male; Opioid Peptides; Prefrontal Cortex; Protein Precursors; Radioimmunoassay; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; Reward; RNA, Messenger; Statistics, Nonparametric; Up-Regulation | 2013 |
Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease.
Topics: Animals; Dynorphins; Dyskinesias; Enkephalins; Female; Immunohistochemistry; Levodopa; Male; Mass Spectrometry; Mice; Mice, Knockout; Parkinson Disease; Protein Precursors; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; Animals; Animals, Newborn; Bromodeoxyuridine; Calbindins; Choline O-Acetyltransferase; Dopamine Agents; Dopamine and cAMP-Regulated Phosphoprotein 32; Doublecortin Domain Proteins; Dynorphins; Enkephalins; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neostriatum; Neurons; Neuropeptides; Nitric Oxide Synthase; Patch-Clamp Techniques; Rats; RNA, Messenger; S100 Calcium Binding Protein G; Tubulin; Tyrosine 3-Monooxygenase | 2011 |
The role of endogenous dynorphin in ethanol-induced state-dependent CPP.
Topics: Animals; Central Nervous System Depressants; Conditioning, Operant; Drug Administration Schedule; Dynorphins; Enkephalins; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Protein Precursors; Sex Factors; Time Factors | 2012 |
CREB involvement in the regulation of striatal prodynorphin by nicotine.
Topics: Adenylyl Cyclases; Animals; Benzazepines; Corpus Striatum; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Male; Mecamylamine; Mice; Nicotine; Phosphorylation; Protein Binding; Protein Precursors; Response Elements; Time Factors; Transcription, Genetic | 2012 |
Effects of surgery and/or remifentanil administration on the expression of pERK1/2, c-Fos and dynorphin in the dorsal root ganglia in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dynorphins; Enkephalins; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pain, Postoperative; Piperidines; Protein Precursors; Proto-Oncogene Proteins c-fos; Remifentanil; RNA, Messenger | 2012 |
Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue.
Topics: Analgesics, Opioid; Animals; Dynorphins; Enkephalins; Neurons; Neuropeptides; Rats; Receptors, Opioid, mu; Ultraviolet Rays | 2012 |
Fluoxetine potentiation of methylphenidate-induced neuropeptide expression in the striatum occurs selectively in direct pathway (striatonigral) neurons.
Topics: Animals; Autoradiography; Central Nervous System Stimulants; Corpus Striatum; Drug Synergism; Dynorphins; Early Growth Response Protein 1; Enkephalins; Fluoxetine; Gene Expression Regulation; Male; Methylphenidate; Neural Pathways; Neurons; Neuropeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Substance P; Substantia Nigra | 2012 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |
Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Animals; Animals, Newborn; Cells, Cultured; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression Regulation, Developmental; Grooming; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 2012 |
Enkephalin surges in dorsal neostriatum as a signal to eat.
Topics: Animals; Brain Mapping; Cacao; Dynorphins; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Feeding Behavior; Hyperphagia; Neostriatum; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Signal Transduction | 2012 |
Exploring the enkephalinergic differentiation potential in adult stem cells for cell therapy and drug screening implications.
Topics: Basic-Leucine Zipper Transcription Factors; Biomarkers; Drug Evaluation, Preclinical; Dynorphins; Enkephalins; Flow Cytometry; Humans; Ikaros Transcription Factor; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neurogenesis; Neurons; Protein Precursors; Signal Transduction; Stem Cell Transplantation; Stem Cells | 2012 |
Effect of opioid peptides on the content of LPO products and antioxidant enzyme activity in the liver of rats after restraint stress.
Topics: Analgesics, Opioid; Animals; Catalase; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Stress, Physiological; Superoxide Dismutase | 2012 |
Adaptive gene expression changes on the healthy side of parkinsonian rats.
Topics: Adaptation, Physiological; Adrenergic Agents; Animals; Cerebral Cortex; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Female; Functional Laterality; Gene Expression Profiling; Locomotion; Neostriatum; Nerve Tissue Proteins; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Tyrosine 3-Monooxygenase | 2013 |
Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood.
Topics: Animals; Behavior, Animal; Brain; Delayed-Action Preparations; Dynorphins; Enkephalins; Female; Gene Expression; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neostriatum; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration | 2012 |
Chronic nicotine treatment impacts the regulation of opioid and non-opioid peptides in the rat dorsal striatum.
Topics: Administration, Oral; Amino Acid Sequence; Animals; Chromatography, Liquid; Chronic Disease; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression Regulation; Isotope Labeling; Male; Molecular Sequence Data; Nerve Tissue Proteins; Neuropeptides; Nicotine; Protein Precursors; Proteome; Rats; Rats, Long-Evans; Somatostatin; Tandem Mass Spectrometry; Tobacco Use Disorder | 2013 |
Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dynorphins; Early Growth Response Protein 1; Enkephalins; Functional Laterality; Gene Expression Regulation; Male; Motor Neurons; Movement; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2013 |
Enkephalin and dynorphin mRNA expression are associated with resilience or vulnerability to chronic social defeat stress.
Topics: Adaptation, Psychological; Amygdala; Animals; Dynorphins; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Resilience, Psychological; RNA, Messenger; Stress, Psychological | 2013 |
Sex and estrogen receptor expression influence opioid peptide levels in the mouse hippocampal mossy fiber pathway.
Topics: Animals; CA3 Region, Hippocampal; Dentate Gyrus; Dynorphins; Enkephalins; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrous Cycle; Female; Male; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Sex Characteristics | 2013 |
Locomotor velocity and striatal adaptive gene expression changes of the direct and indirect pathways in Parkinsonian rats.
Topics: Animals; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Female; Gene Expression; Glutamate Decarboxylase; Hydroxydopamines; Immunohistochemistry; In Situ Hybridization; Motor Activity; Neostriatum; Neural Pathways; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; RNA, Messenger; Signal Transduction; Tyrosine 3-Monooxygenase | 2013 |
Early modulation by the dopamine D4 receptor of morphine-induced changes in the opioid peptide systems in the rat caudate putamen.
Topics: Analgesics, Opioid; Animals; Dynorphins; Enkephalins; Immunohistochemistry; In Situ Hybridization; Male; Morphine; Opioid Peptides; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Receptors, Opioid, mu; RNA, Messenger | 2013 |
Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens.
Topics: Animals; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; Epigenesis, Genetic; Gene Expression Regulation; Histones; Male; Nociceptin; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 2014 |
Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus.
Topics: Aged; Aged, 80 and over; Axons; beta-Endorphin; Dynorphins; Enkephalin, Leucine; Female; Growth Hormone-Releasing Hormone; Humans; Hypothalamus; Immunohistochemistry; Male; Median Eminence; Neurons; Opioid Peptides; Pituitary Gland, Posterior | 2014 |
Dopamine D₄ receptor counteracts morphine-induced changes in µ opioid receptor signaling in the striosomes of the rat caudate putamen.
Topics: Adaptation, Physiological; Animals; Dopamine Agonists; Dynorphins; Enkephalins; Male; Morphine; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Receptors, Opioid, mu; RNA, Messenger; Signal Transduction | 2014 |
Long-term treatment with l-DOPA and an mGlu5 receptor antagonist prevents changes in brain basal ganglia dopamine receptors, their associated signaling proteins and neuropeptides in parkinsonian monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Basal Ganglia; Corpus Striatum; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Excitatory Amino Acid Antagonists; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Levodopa; Macaca fascicularis; MAP Kinase Signaling System; Parkinsonian Disorders; Protein Precursors; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger | 2014 |
Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice.
Topics: Animals; Behavior, Animal; beta-Endorphin; Central Nervous System Sensitization; Cytokines; Disease Models, Animal; Dynorphins; Enkephalins; Hyperalgesia; Inflammation; Interleukin-10; Interleukin-13; Interleukin-17; Interleukin-1beta; Interleukin-2; Interleukin-6; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neutrophils; Nociception; Peripheral Nerve Injuries; Peroxidase; Sciatic Nerve; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
Effect of intravenous general anaesthesia with epidural block on the expression of pre-endogenous opioid peptide genes.
Topics: Abdomen; Adult; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intravenous; beta-Endorphin; Bupivacaine; Dynorphins; Enkephalin, Leucine; Enkephalins; Female; Fentanyl; Gene Expression; Humans; Male; Midazolam; Middle Aged; Pain; Prospective Studies; Protein Precursors; Radioimmunoassay; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vecuronium Bromide | 2014 |
Wheel running alters patterns of uncontrollable stress-induced cfos mRNA expression in rat dorsal striatum direct and indirect pathways: A possible role for plasticity in adenosine receptors.
Topics: Animals; Corpus Striatum; Corticosterone; Dynorphins; Electroshock; Enkephalins; Gene Expression; Male; Motor Activity; Neurons; Proto-Oncogene Proteins c-fos; Random Allocation; Rats, Inbred F344; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Running; Stress, Psychological | 2014 |
Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity.
Topics: Action Potentials; Animals; Arcuate Nucleus of Hypothalamus; Choice Behavior; Corpus Striatum; Dietary Fats; Dietary Sucrose; Dynorphins; Eating; Enkephalins; Feeding Behavior; Male; Mice, Inbred C57BL; Neurons; Neuropeptide Y; Nucleus Accumbens; Protein Precursors; Rats, Wistar; Receptors, Neuropeptide Y; RNA, Messenger | 2015 |
Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons.
Topics: Adult; Case-Control Studies; Catecholamines; Cells, Cultured; Dynorphins; Enkephalins; Exocytosis; Female; Humans; Induced Pluripotent Stem Cells; Infant, Newborn; Male; Neural Stem Cells; Neurons; Schizophrenia | 2014 |
Specific contributions of N-methyl-D-aspartate receptors in the dorsal striatum to cognitive flexibility.
Topics: Animals; Cognition; Corpus Striatum; Dynorphins; Enkephalins; Executive Function; Exploratory Behavior; HEK293 Cells; Humans; Maze Learning; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nerve Tissue Proteins; Neuronal Plasticity; Protein Precursors; Psychomotor Performance; Receptors, N-Methyl-D-Aspartate; Reversal Learning | 2015 |
Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
Topics: Aging; Animals; Dynorphins; Enkephalins; Female; Follicle Stimulating Hormone; Hypothalamus; Kisspeptins; Luteinizing Hormone; Male; Neurokinin B; Peptide Fragments; Protein Precursors; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2015 |
Endogenous opioids as substrates for ethanol intake in the neonatal rat: The impact of prenatal ethanol exposure on the opioid family in the early postnatal period.
Topics: Age Factors; Alcohol Drinking; Analysis of Variance; Animals; Animals, Newborn; Brain; Central Nervous System Depressants; Dynorphins; Enkephalins; Ethanol; Female; Gene Expression Regulation, Developmental; Gestational Age; Male; Pregnancy; Prenatal Exposure Delayed Effects; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger | 2015 |
Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction.
Topics: Analgesics, Opioid; Animals; Cell Membrane; Dynorphins; Endorphins; Enkephalins; Humans; Ligands; Microscopy, Confocal; Neuropeptides; Opioid Peptides; PC12 Cells; Protein Precursors; Rats; Signal Transduction | 2015 |
Deconstructing 5-HT6 receptor effects on striatal circuit function.
Topics: Animals; Conditioning, Operant; Dynorphins; Enkephalins; Genetic Vectors; Male; Neostriatum; Neurons; Protein Precursors; Rats; Rats, Long-Evans; Receptors, Serotonin | 2015 |
Liquid chromatography-electrospray linear ion trap mass spectrometry analysis of targeted neuropeptides in Tac1(-/-) mouse spinal cords reveals significant lower concentration of opioid peptides.
Topics: Animals; Chromatography, Liquid; Dynorphins; Enkephalin, Leucine; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Oligopeptides; Spectrometry, Mass, Electrospray Ionization; Spinal Cord; Tachykinins | 2015 |
From unilateral to bilateral parkinsonism: Effects of lateralization on dyskinesias and associated molecular mechanisms.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Functional Laterality; Levodopa; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats, Sprague-Dawley; RNA, Messenger | 2015 |
Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Nociception; Receptors, Opioid, delta; Spinal Cord | 2016 |
Enkephalin levels and the number of neuropeptide Y-containing interneurons in the hippocampus are decreased in female cannabinoid-receptor 1 knock-out mice.
Topics: Animals; Cell Count; Cholecystokinin; Dynorphins; Enkephalin, Leucine; Female; Hippocampus; Interneurons; Mice; Mice, Inbred C57BL; Mice, Knockout; Mossy Fibers, Hippocampal; Neuropeptide Y; Receptor, Cannabinoid, CB1 | 2016 |
Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Gene Expression Regulation; Levodopa; Oxidopamine; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; RNA, Messenger; Statistics as Topic; Sympatholytics; Tyrosine 3-Monooxygenase | 2016 |
Altered secondary structure of Dynorphin A associates with loss of opioid signalling and NMDA-mediated excitotoxicity in SCA23.
Topics: Amino Acid Sequence; Animals; Cell Culture Techniques; Computer Simulation; Dynorphins; Endorphins; Enkephalins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neurotoxins; Protein Precursors; Protein Structure, Secondary; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Spinocerebellar Degenerations | 2016 |
Mu and delta opioid receptor knockout mice show increased colonic sensitivity.
Topics: Analgesics, Opioid; Animals; Colitis; Dextran Sulfate; Dynorphins; Enkephalins; Female; Interleukin-1beta; Male; Mice; Mice, Knockout; Pain; Pain Management; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Necrosis Factor-alpha | 2017 |
Opioid precursor protein isoform is targeted to the cell nuclei in the human brain.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Animals; Caudate Nucleus; Cell Line, Tumor; Cell Nucleus; Dynorphins; Enkephalins; Female; Gene Expression Regulation; Gene Silencing; Humans; Male; Middle Aged; Opioid Peptides; Protein Isoforms; Protein Precursors; Rats; RNA, Messenger; Young Adult | 2017 |
Effects of Opioid Peptides on Changes in Lipid Metabolism in Rats Subjected to Swimming Stress.
Topics: Analgesics, Opioid; Animals; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Fatty Acids, Nonesterified; Lipid Metabolism; Male; Peptide Fragments; Rats; Rats, Wistar; Stress, Psychological; Swimming; Triglycerides | 2017 |
Peptidergic nature of nociception-related projections from the hypothalamic paraventricular nucleus to the dorsal horn of the spinal cord.
Topics: Animals; Dynorphins; Enkephalins; Male; Neurons; Nociception; Oxytocin; Paraventricular Hypothalamic Nucleus; Rats, Wistar; Spinal Cord; Spinal Cord Dorsal Horn; Vasopressins | 2018 |
Diverse serotonin actions of vilazodone reduce l-3,4-dihidroxyphenylalanine-induced dyskinesia in hemi-parkinsonian rats.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Gene Expression Regulation; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Piperazines; Protein Precursors; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Time Factors; Vilazodone Hydrochloride | 2018 |
Short-term withdrawal from repeated exposure to cocaine during adolescence modulates dynorphin mRNA levels and BDNF signaling in the rat nucleus accumbens.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine-Related Disorders; Dynorphins; Enkephalins; Gene Expression; Male; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; RNA, Messenger; Signal Transduction; Substance Withdrawal Syndrome | 2019 |
Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Gene Expression Regulation; Levodopa; Male; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Tyrosine 3-Monooxygenase | 2020 |
Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy.
Topics: Animals; Brain; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Globus Pallidus; Levodopa; Male; Neostriatum; Parkinsonian Disorders; Rats, Wistar | 2020 |
Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses.
Topics: Animals; Dynorphins; Enkephalins; Female; Hot Temperature; Male; Mice; Mice, Transgenic; Optogenetics; Parabrachial Nucleus; Preoptic Area; Protein Precursors | 2021 |
Contribution of the μ opioid receptor and enkephalin to the antinociceptive actions of endomorphin-1 analogs with unnatural amino acid modifications in the spinal cord.
Topics: Analgesics; Animals; Chronic Pain; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Mice; Naloxone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu; Spinal Cord | 2021 |
Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice.
Topics: Animals; Corpus Striatum; Dynorphins; Enkephalins; In Situ Hybridization, Fluorescence; Mice; Neurons; Olfactory Tubercle; Protein Precursors; Receptors, Dopamine D1; RNA, Messenger | 2022 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |