enkephalin, leucine has been researched along with diprenorphine in 102 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 46 (45.10) | 18.7374 |
1990's | 51 (50.00) | 18.2507 |
2000's | 5 (4.90) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Kuhar, MJ | 1 |
Herz, A; Höllt, V; Osborne, H | 1 |
Kuhar, MJ; Young, WS | 1 |
Baamonde, A; Fournie-Zaluski, MC; Roques, BP; Ruiz-Gayo, M; Turcaud, S | 1 |
Edwards, RH; Evans, CJ; Keith, DE; Magendzo, K; Morrison, H | 1 |
Dissanayake, VU; Hughes, J; Hunter, JC | 1 |
Lawrence, AJ; Traynor, JR | 1 |
Barg, J; Hatini, V; Simantov, R | 1 |
Attali, B; Saya, D; Vogel, Z | 1 |
Costa, T; Herz, A; Ott, S | 1 |
Cox, BM; Puttfarcken, PS | 1 |
Kamikubo, K; Miura, K; Murase, H; Murayama, M; Tsurumi, K; Yasuda, K | 2 |
Kamikubo, K; Matsuda, M; Miura, K; Murase, H; Murayama, M | 1 |
Imai, T; Kamikubo, K; Miura, K; Miura, Y; Miyashita, T; Murase, H; Nakamura, S; Niwa, M; Satoh, T; Tomita, A | 1 |
Cox, BM; Puttfarcken, PS; Werling, LL | 1 |
Law, PY; Loh, HH; Louie, AK; Zhan, JN | 1 |
Cros, J; Francés, B; Meunier, JC; Porthé, G; Verrier, B | 1 |
Farges, RC; Meunier, JC; Moisand, C; Puget, A | 1 |
Ahmad, S; Allescher, HD; Daniel, EE; Dent, J; Fox, JE; Kostolanska, F | 1 |
Chang, LR; Law, PY; Loh, HH; Tao, PL | 1 |
Falke, NE; Fischer, EG; Martin, R | 1 |
Frances, B; Meunier, JC; Moisand, C | 1 |
Falke, N; Martin, R | 1 |
Hom, DS; Law, PY; Loh, HH | 1 |
Barber, DJ; Barbour-McMullen, J; Cooper, SJ | 1 |
Costa, T; Gramsch, C; Herz, A; Wüster, M | 1 |
Gottlieb, DI; Mattler, JA; Slaughter, MM | 1 |
Bidlack, JM; Denton, RR | 1 |
Richards, ML; Sadée, W; Yu, VC | 1 |
Charness, ME; Diamond, I; Querimit, LA | 1 |
Klein, C; Levy, R; Simantov, R | 1 |
Belenky, GL; Hitzemann, RJ; Holaday, JW; Long, JB; Tortella, FC | 1 |
Brown, SR; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
Costa, T; Herz, A; Vachon, L | 1 |
Kamikubo, K; Miura, K; Murase, H; Niwa, M; Nozaki, M; Tsurumi, K | 1 |
Bruzzone, ME; Marusic, ET | 1 |
Lee, NM; Loh, HH; Roy, S; Zhu, YX | 1 |
Ewen, M; Gregor, L; Saunders, WS; Thornhill, JA; Wilfong, AA | 1 |
Aktories, K; Costa, T; Jakobs, KH; Wüster, M | 1 |
Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 1 |
Blanchard, SG; Chang, KJ; Cuatrecasas, P | 1 |
Chang, KJ; Cuatrecasas, P; Hazum, E | 2 |
Chang, KJ; Cuatrecasas, P; Hazum, E; Killian, A | 1 |
Dekker, I; Martinez, JL; Rigter, H | 1 |
Kachur, JF; Miller, RJ | 1 |
Costa, T; Członkowski, A; Herz, A; Pasí, A; Przewłocki, R | 1 |
Gioannini, TL; Hiller, JM; Itzhak, Y; Simon, EJ | 1 |
Fogel, R; Kaplan, RB | 1 |
Bellet, M; Elghozi, JL; Meyer, P | 1 |
Rothman, RB; Westfall, TC | 1 |
Chen, C; Chen, YW; Kim de Riel, J; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
Nahorski, SR; Traynor, JR | 1 |
Chen, C; de Riel, JK; Kunapuli, SP; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
Elliott, J; Lambert, DG; Smart, D; Traynor, JR | 1 |
Jauzac, P; Polastron, J | 1 |
Iwai, T; Luay, AE; Niwa, M; Nozaki, M; Tsurumi, K | 1 |
Bare, LA; Mansson, E; Yang, D | 1 |
Fu, R; Gaskill, MB; Iwasaki, Y; Robertson, GL; Saper, CB | 1 |
Ishige, K; Ito, Y; Makimura, M; Murakoshi, Y | 1 |
Baumhaker, Y; Goldstein, MN; Sarne, Y; Wollman, Y | 1 |
Campbell, DJ; Lambert, DG; Rowbotham, DJ | 2 |
Chalecka-Franaszek, E; Côté, TE; Weems, HB | 1 |
Casulari, LA; Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
Feigenbaum, JJ; Simantov, R | 1 |
Gallagher, M; Gill, TM; Nagahara, AH; Nicolle, M | 1 |
Castanas, E; Hatzoglou, A; Kampa, M; Loukas, S; Martin, P; Martin, PM | 1 |
Kübler, W; Mura, RA; Niroomand, F; Piacentini, L | 1 |
Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
Buzas, B; Cox, BM; Rosenberger, J | 1 |
Campbell, KM; Erickson, LE; Law, PY; Loh, HH; McGinn, TM | 1 |
Chen, JJ; Dymshitz, J; Vasko, MR | 1 |
Cheng, Z; Pei, G; Wang, C; Wu, Y; Zhou, D; Zhu, X | 1 |
Capeyrou, R; Dietrich, G; Emorine, LJ; Gaibelet, G | 1 |
Harikumar, KG; Janardana Sarma, MK; Sailaja, P; Sastry, KV | 1 |
Chakrabarti, S; Law, PY; Loh, HH; Yang, W | 1 |
Baroche, L; Kieffer, B; Massotte, D; Pattus, F; Simonin, F; Yu, L | 1 |
Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J | 1 |
Devi, LA; Hirst, RA; Lambert, DG; Smart, D | 1 |
Avram, D; Bouvier, C; Hettinger, B; Leid, M; Murray, TF; Peterson, VJ; Soderstrom, K | 1 |
Fukuda, K; Kato, S; Mima, H; Mori, K; Morikawa, H; Shoda, T | 1 |
Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB | 1 |
Kramer, HK; Simon, EJ | 2 |
Castanas, E; Denizot, A; Dermitzaki, I; Gravanis, A; Hatzoglou, A; Henry, JF; Kampa, M; Margioris, AN; Oliver, C | 1 |
Chen, J; Chi, ZQ; Li, GE; Pei, G; Wang, CH; Zhou, DH | 1 |
Chen, C; de Riel, JK; Li, JG; Liu-Chen, LY; Ozdener, F; Weinstein, H; Xu, W | 1 |
Emorine, LJ; Exner, T; Gaibelet, G; Liaubet, L; Masson, JM; Meilhoc, E; Nürnberg, B; Riond, J; Saves, I | 1 |
Clark, MJ; Emmerson, PJ; Medzihradsky, F; Remmers, AE | 1 |
Caffrey, JL | 1 |
Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L; SanMartín, S | 1 |
Babey, AM; Cavalli, A; Loh, HH | 1 |
Castanas, E; Chatzaki, E; Georgoulias, V; Gravanis, A; Makrigiannakis, A; Margioris, AN | 1 |
Caffrey, JL; Farias, M; Jackson, K; Stanfill, A | 1 |
Andersson, KE; Andersson, M; Cenci, MA; Johansson, PA | 1 |
Bhatia, KP; Brooks, DJ; Edwards, M; Hammers, A; Valente, EM; Von Spiczak, S; Whone, AL | 1 |
Baumgartner, C; Czech, T; Feucht, M; Gasser, E; Novak, K; Pirker, S; Schuh, E; Sperk, G; Zimprich, F | 1 |
Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
2 review(s) available for enkephalin, leucine and diprenorphine
Article | Year |
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Histochemical localization of opiate receptors and opioid peptides.
Topics: Animals; Autoradiography; Axons; Binding Sites; Brain Chemistry; Diprenorphine; Electrophysiology; Enkephalins; Fluorescent Antibody Technique; Histocytochemistry; Peptides; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Spinal Cord | 1978 |
Endogenous opioids and their receptors. Evidence for involvement in the postictal effects of electroconvulsive shock.
Topics: Animals; Anticonvulsants; Autonomic Nervous System; Blood Pressure; Brain; Diprenorphine; Drug Tolerance; Electroconvulsive Therapy; Electroencephalography; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Heart Rate; Morphine; Naloxone; Pain; Pituitary Gland; Pressoreceptors; Rats; Receptors, Opioid; Sensory Thresholds; Tritium | 1986 |
100 other study(ies) available for enkephalin, leucine and diprenorphine
Article | Year |
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Subcellular distribution of enkephalins and endogenous opioid activity in rat brain.
Topics: Animals; Brain; Diprenorphine; Endorphins; Enkephalins; Male; Microsomes; Radioimmunoassay; Radioligand Assay; Rats; Receptors, Opioid; Subcellular Fractions; Synaptosomes | 1978 |
A new method for receptor autoradiography: [3H]opioid receptors in rat brain.
Topics: Animals; Autoradiography; Brain; Corpus Striatum; Dihydromorphine; Diprenorphine; Enkephalins; Frontal Lobe; Guanosine Triphosphate; Histological Techniques; Male; Rats; Receptors, Opioid; Sodium; Tritium | 1979 |
In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding.
Topics: Analgesics; Animals; Brain; Cell Membrane; Diprenorphine; Disulfides; Enkephalins; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylalanine; Receptors, Opioid; Stress, Psychological; Tritium | 1992 |
Cloning of a delta opioid receptor by functional expression.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Blotting, Southern; Cell Line; Cyclic AMP; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Gene Expression; Humans; Kinetics; Models, Structural; Molecular Sequence Data; Naloxone; Narcotics; Protein Structure, Secondary; Receptors, Opioid, delta; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured | 1992 |
Opioid binding sites in the guinea pig and rat kidney: radioligand homogenate binding and autoradiography.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Cations; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Kidney; Kinetics; Narcotic Antagonists; Nucleotides; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Tritium | 1991 |
Characterisation of opioid binding sites using selective antagonists.
Topics: Animals; Binding, Competitive; Brain; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Morphinans; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
Developmental pattern of opioid receptors in the striatum and hippocampus: evidence for a non-mature type of receptor in embryonic tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hippocampus; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Pre- and postnatal development of opiate receptor subtypes in rat spinal cord.
Topics: Aging; Animals; Binding, Competitive; Diprenorphine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1990 |
Opioid receptors of neuroblastoma cells are in two domains of the plasma membrane that differ in content of G proteins.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Fractionation; Cell Membrane; Centrifugation; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Morphine-induced desensitization and down-regulation at mu-receptors in 7315C pituitary tumor cells.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Morphine; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1989 |
[Characterization of adrenal medullary opioid receptors. I. Binding of opioids to adrenal medullary opioid receptors].
Topics: Adrenal Medulla; Animals; Cattle; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; In Vitro Techniques; Metals; Morphinans; Pheochromocytoma; Receptors, Opioid; Tritium | 1987 |
[Characterization of adrenal medullary opioid receptors. II. Coupling of adrenal medullary opioid receptors to GTP binding proteins].
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenal Medulla; Animals; Cattle; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; In Vitro Techniques; Levorphanol; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1987 |
Evidence for disulfide bonds in membrane-bound and solubilized opioid receptors.
Topics: Adrenal Medulla; Animals; Cattle; Cell Membrane; Chromatography, Gel; Digitonin; Diprenorphine; Disulfides; Dithiothreitol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanylyl Imidodiphosphate; Hydrogen Peroxide; Kinetics; Mercaptoethanol; Molecular Weight; Receptors, Opioid; Solubility | 1988 |
Varying expression of opioid receptors and GTP-binding proteins in human pheochromocytomas.
Topics: Adrenal Gland Neoplasms; beta-Endorphin; Cell Membrane; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; GTP-Binding Proteins; Humans; Pheochromocytoma; Receptors, Opioid | 1986 |
Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.
Topics: Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanine Nucleotides; Guinea Pigs; Kinetics; Male; Naloxone; Oligopeptides; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1988 |
Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Acid Phosphatase; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanfacine; Guanidines; Hybrid Cells; Neuroblastoma; Phenylacetates; Receptors, Opioid | 1988 |
The kappa-opioid receptor from human placenta: hydrodynamic characteristics and evidence for its association with a G protein.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Binding, Competitive; Centrifugation, Density Gradient; Chromatography, Gel; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Microvilli; Oligopeptides; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride | 1988 |
Opioid receptor types in the brain of the Afghan pika (Ochotona rufescens), a species which is naturally tolerant to morphine.
Topics: Animals; Binding, Competitive; Brain Chemistry; Diprenorphine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanylyl Imidodiphosphate; Lagomorpha; Membranes; Morphine; Oligopeptides; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1988 |
Inhibitory opioid receptors in canine pylorus.
Topics: Animals; Diprenorphine; Dogs; Duodenum; Electric Stimulation; Enkephalins; Female; Kinetics; Male; Naloxone; Narcotics; Pressure; Pyloric Antrum; Pylorus; Receptors, Opioid; Saxitoxin | 1988 |
Decrease in delta-opioid receptor density in rat brain after chronic [D-Ala2,D-Leu5]enkephalin treatment.
Topics: Animals; Brain; Diprenorphine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Time Factors | 1988 |
Stereospecific opiate binding in living human polymorphonuclear leucocytes.
Topics: Analgesics, Opioid; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Granulocytes; Humans; Kinetics; Naloxone; Neutrophils; Receptors, Opioid | 1985 |
Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at mu- and kappa-opioid receptor sites in rabbit and guinea-pig cerebellum membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1985 |
Opioid binding in a rat neurohypophysial fraction enriched in oxytocin and vasopressin nerve endings.
Topics: Animals; Arginine Vasopressin; Binding Sites; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats | 1985 |
Multiple affinity states of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Opiate agonist association rate is a function of receptor occupancy.
Topics: Animals; Binding, Competitive; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Magnesium; Neuroblastoma; Receptors, Opioid; Sodium | 1985 |
Selective attenuation of sweetened milk consumption by opiate receptor antagonists in male and female rats of the Roman strains.
Topics: Animals; Appetite Depressants; Azocines; Benzomorphans; Diprenorphine; Enkephalin, Leucine; Feeding Behavior; Female; Male; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid; Sex Factors; Species Specificity | 1985 |
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Hybrid Cells; Kinetics; Ligands; Morphine; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Opiate binding sites in the chick, rabbit and goldfish retina.
Topics: Animals; Benzomorphans; Chickens; Dihydromorphine; Diprenorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Goldfish; Oligopeptides; Rabbits; Receptors, Opioid; Retina; Species Specificity | 1985 |
A monoclonal antibody capable of modulating opioid binding to rat neural membranes.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cyclazocine; Dihydromorphine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Flunitrazepam; Immunoglobulin M; Kinetics; Male; Mice; Mice, Inbred BALB C; Molecular Weight; Naloxone; Narcotics; Nerve Tissue; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
A human neuroblastoma cell line expresses mu and delta opioid receptor sites.
Topics: Bone Neoplasms; Cell Line; Child, Preschool; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Guanylyl Imidodiphosphate; Humans; Kinetics; Naloxone; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Diprenorphine; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Etorphine; Glioma; Hybridomas; Naloxone; Neuroblastoma; Phenylisopropyladenosine; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Transcription, Genetic | 1986 |
Subcellular compartmentation of opioid receptors: modulation by enkephalin and alkaloids.
Topics: Animals; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Chloroquine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Golgi Apparatus; Kinetics; Lysosomes; Microsomes; Neuroblastoma; Receptors, Opioid | 1986 |
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Guinea Pigs; Male; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1986 |
GTPase and adenylate cyclase desensitize at different rates in NG108-15 cells.
Topics: Adenylyl Cyclase Inhibitors; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Phosphoric Monoester Hydrolases; Receptors, Opioid | 1987 |
Coupling of adrenal medullary opioid receptors to islet-activating protein-sensitive GTP-binding proteins.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adrenal Medulla; Animals; Cattle; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1987 |
Effects of opioid peptides on aldosterone production: stimulatory effect of leu-enkephalin.
Topics: Adrenal Cortex; Aldosterone; Animals; Cattle; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Perfusion | 1988 |
A monoclonal antibody that inhibits opioid binding to rat brain membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antibodies, Monoclonal; Brain; Cattle; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme-Linked Immunosorbent Assay; Membranes; Narcotics; Pyrrolidines; Rats | 1988 |
Pressor effects of systemic administration of methionine and leucine enkephalin in the conscious rat.
Topics: Animals; Atropine; Blood Pressure; Diprenorphine; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guanethidine; Heart Rate; Naloxone; Norepinephrine; Phentolamine; Propranolol; Rats | 1986 |
Sodium regulation of opioid agonist binding is potentiated by pertussis toxin.
Topics: Animals; Bacterial Toxins; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanine Nucleotides; Hybrid Cells; Mice; Morphinans; Neuroblastoma; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Virulence Factors, Bordetella | 1984 |
Radioligands for probing opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1984 |
Benzomorphan sites are ligand recognition sites of putative epsilon-receptors.
Topics: Animals; Benzomorphans; beta-Endorphin; Binding, Competitive; Brain; Cell Membrane; Diprenorphine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Guinea Pigs; Humans; Kinetics; Morphinans; Peptide Fragments; Placenta; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Diprenorphine; Endorphins; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Morphinans; Morphine; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Synaptic Membranes | 1980 |
Interactions of ligands with morphine and enkephalin receptors are differentially affected by guanine nucleotide.
Topics: Animals; Brain; Cells, Cultured; Diprenorphine; Endorphins; Enkephalins; Guanosine Triphosphate; In Vitro Techniques; Magnesium; Naloxone; Neoplasms, Experimental; Neuroblastoma; Rats; Receptors, Opioid; Sodium | 1981 |
Novel opiate binding sites selective for benzomorphan drugs.
Topics: Animals; Benzomorphans; Binding, Competitive; Brain; Brain Mapping; Diprenorphine; Endorphins; Enkephalins; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1981 |
A comparison of the ability of opioid peptides and opiates to affect active avoidance conditioning in rats.
Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Diprenorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Naloxone; Narcotics; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Characterization of the opiate receptor in the guinea-pig ileal mucosa.
Topics: Animals; Diprenorphine; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Naloxone; Narcotics; Receptors, Opioid | 1982 |
Opiate receptor binding sites in human spinal cord.
Topics: Aged; beta-Lipotropin; Binding, Competitive; Brain; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Male; Middle Aged; Peptide Fragments; Receptors, Opioid; Spinal Cord; Substantia Gelatinosa | 1983 |
Effect of digitonin on the binding of opiate agonists and antagonists to membrane-bound and soluble opioid binding sites.
Topics: Animals; Brain; Bufo marinus; Digitonin; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Species Specificity | 1984 |
Role of enkephalins in regulation of basal intestinal water and ion absorption in the rat.
Topics: Animals; Atropine; Colon; Diprenorphine; Enkephalins; Intestine, Small; Male; Morphine; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Water-Electrolyte Balance | 1984 |
[Implication of enkephalins in central cardiovascular regulation in the rat].
Topics: Animals; Autonomic Nervous System; Blood Pressure; Diprenorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Heart Rate; Hypertension; Injections, Spinal; Naloxone; Oxygen; Rats; Rats, Inbred Strains; Respiration | 1982 |
Morphine allosterically modulates the binding of [3H]leucine enkephalin to a particulate fraction of rat brain.
Topics: Allosteric Site; Animals; Brain; Buffers; Diprenorphine; Endorphins; Enkephalin, Leucine; Enkephalins; Female; In Vitro Techniques; Kinetics; Models, Biological; Morphine; Naloxone; Rats; Rats, Inbred Strains; Subcellular Fractions; Time Factors | 1982 |
Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Glycosylation; Molecular Sequence Data; Naltrexone; Oligopeptides; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sodium; Tritium | 1995 |
Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.
Topics: Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Narcotics; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1995 |
The third extracellular loop of the mu opioid receptor is important for agonist selectivity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Diprenorphine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Molecular Sequence Data; Morphine; Protein Conformation; Rats; Receptors, Opioid, mu; Sufentanil | 1995 |
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss | 1995 |
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
Topics: Amino Acid Sequence; Animals; Brain Neoplasms; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured | 1994 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Characterization of opioid receptors in the Mongolian gerbil cerebellum.
Topics: Animals; Autoradiography; Benzeneacetamides; Binding Sites; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gerbillinae; Guanylyl Imidodiphosphate; In Vitro Techniques; Narcotics; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu | 1994 |
Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; CHO Cells; Colforsin; Cricetinae; Diprenorphine; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Genetic Variation; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Receptors, Opioid, mu; RNA, Messenger; Transfection | 1994 |
Opioid antagonist diprenorphine microinjected into parabrachial nucleus selectively inhibits vasopressin response to hypovolemic stimuli in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Disease; Animals; Antihypertensive Agents; Brain; Cerebral Ventricles; Diprenorphine; Enkephalin, Leucine; Hemodynamics; Male; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Shock; Solitary Nucleus; Stimulation, Chemical; Vasopressins | 1993 |
Inhibitory effects of NaCl and guanyl-5'yl-imidodiphosphate (GppNHp) on [3H]naloxone binding to kappa-opioid receptors in guinea pig cerebellum.
Topics: Animals; Benzeneacetamides; Binding Sites; Cerebellum; Cerebral Cortex; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Guanylyl Imidodiphosphate; Guinea Pigs; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sodium Chloride | 1993 |
Evidence for mu-, delta-, and kappa-opioid receptors in a human neuroblastoma cell line.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Binding, Competitive; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Tritium; Tumor Cells, Cultured | 1993 |
Effects of halothane on mu opioid binding in SH-SY5Y cells.
Topics: Anesthetics, Inhalation; Cell Line; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Halothane; Humans; Kinetics; Narcotic Antagonists; Receptors, Opioid, mu | 1995 |
Do nitrous oxide and halothane influence opioid receptor binding in SH-SY5Y human neuroblastoma cells?
Topics: Analgesics; Anesthetics, Inhalation; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Halothane; Humans; Neuroblastoma; Nitrous Oxide; Receptors, Opioid; Tumor Cells, Cultured | 1995 |
Solubilization of high-affinity, guanine nucleotide-sensitive mu-opioid receptors from rat brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cholic Acids; Detergents; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanine Nucleotides; Membranes; Precipitin Tests; Rats; Rats, Inbred BUF; Receptors, Opioid, mu; Solubility | 1996 |
Antiprogestins inhibit the binding of opioids to mu-opioid receptors in nervous membrane preparations.
Topics: Analgesics; Animals; Dihydromorphine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gonanes; Hormone Antagonists; Humans; In Vitro Techniques; Male; Membranes; Mice; Mifepristone; Narcotic Antagonists; Narcotics; Nerve Tissue; Nervous System Neoplasms; Neuroblastoma; Progestins; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sodium; Tumor Cells, Cultured | 1996 |
Lack of effect of gamma-hydroxybutyrate on mu, delta and kappa opioid receptor binding.
Topics: Adjuvants, Anesthesia; Analgesics; Animals; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Glioma; Guinea Pigs; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Oxybate; Tritium; Tumor Cells, Cultured | 1996 |
Alterations in opiate receptor binding in the hippocampus of aged Long-Evans rats.
Topics: Age Factors; Aging; Animals; Autoradiography; Binding, Competitive; Diprenorphine; Enkephalins; Hippocampus; Male; Rats; Receptors, Opioid | 1996 |
Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide).
Topics: Amino Acid Sequence; Binding, Competitive; Breast Neoplasms; Caseins; Cell Division; Cell Line; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Humans; Kinetics; Peptide Fragments; Receptors, Opioid, kappa | 1996 |
Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Diprenorphine; Dogs; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Myocardium; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Sarcolemma; Virulence Factors, Bordetella | 1996 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Regulation of delta-opioid receptor mRNA levels by receptor-mediated and direct activation of the adenylyl cyclase-protein kinase A pathway.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Binding Sites; Bucladesine; Calcium Channels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diprenorphine; Enkephalin, Leucine; Gene Expression Regulation, Enzymologic; Mice; Neuroblastoma; Protein Synthesis Inhibitors; Receptors, Opioid, delta; RNA, Messenger; Tritium; Tumor Cells, Cultured | 1997 |
Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fetal Blood; Mice; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Regulation of opioid receptors in rat sensory neurons in culture.
Topics: Analgesics; Animals; Cells, Cultured; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Kinetics; Naloxone; Narcotic Antagonists; Neurons, Afferent; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium; Up-Regulation | 1997 |
The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activation.
Topics: Amino Acid Sequence; Animals; Biological Transport; Cell Line; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Humans; Kidney; Mice; Receptors, Opioid, delta; Signal Transduction; Transfection | 1997 |
Identification in the mu-opioid receptor of cysteine residues responsible for inactivation of ligand binding by thiol alkylating and reducing agents.
Topics: Alkylating Agents; Alkylation; Animals; Binding Sites; Cloning, Molecular; COS Cells; Cysteine; Diprenorphine; Disulfides; Dithiothreitol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylmaleimide; Humans; Ligands; Mutagenesis, Site-Directed; Narcotic Antagonists; Protein Binding; Receptors, Opioid, mu; Reducing Agents; Sulfhydryl Reagents; Transfection | 1997 |
Use of zonal centrifugation method for the preparation of mu-opioid receptor enriched membranes from bovine corpus striatum.
Topics: Animals; Cattle; Cell Fractionation; Cell Membrane; Centrifugation, Zonal; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Radioligand Assay; Receptors, Opioid, mu; Subcellular Fractions; Sucrose; Synaptosomes | 1997 |
The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation.
Topics: Animals; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Mice; Pertussis Toxin; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells.
Topics: Analgesics, Opioid; Animals; Baculoviridae; Cells, Cultured; Cloning, Molecular; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Humans; Kinetics; Ligands; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Spodoptera; Transfection | 1997 |
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine | 1997 |
Effects of C-terminal truncation of the recombinant delta-opioid receptor on phospholipase C and adenylyl cyclase coupling.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inositol 1,4,5-Trisphosphate; Mice; Mutation; Receptors, Opioid, delta; Recombinant Proteins; Sequence Deletion; Tumor Cells, Cultured; Type C Phospholipases | 1998 |
Catecholaminergic CATH.a cells express predominantly delta-opioid receptors.
Topics: Adenylyl Cyclases; Animals; Catecholamines; Cell Line; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; In Vitro Techniques; Mice; Narcotic Antagonists; Neurons; Polymerase Chain Reaction; Radioligand Assay; Receptors, Opioid, delta; Receptors, sigma; Signal Transduction | 1998 |
Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Naloxone; Receptors, Cell Surface; Receptors, Opioid; Transfection | 1998 |
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors | 1998 |
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists.
Topics: Analgesics; Analgesics, Opioid; Binding, Competitive; Biological Transport; Carcinogens; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Humans; Kinetics; Membrane Proteins; Morphine; Naloxone; Narcotic Antagonists; Neuroblastoma; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Opioid, mu; Second Messenger Systems; Time Factors; Tritium; Tumor Cells, Cultured | 1999 |
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC.
Topics: Analgesics; Analgesics, Opioid; Biological Transport; Carcinogens; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Humans; Immunoblotting; Isoenzymes; Narcotic Antagonists; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Receptors, Opioid, mu; Second Messenger Systems; Tritium; Tumor Cells, Cultured | 1999 |
Kappa1-opioid binding sites are the dominant opioid binding sites in surgical specimens of human pheochromocytomas and in a human pheochromocytoma (KAT45) cell line.
Topics: Analgesics, Opioid; Binding Sites; Binding, Competitive; Catecholamines; Cell Membrane; Diprenorphine; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epinephrine; Ethylketocyclazocine; Humans; Narcotic Antagonists; Norepinephrine; Opioid Peptides; Pheochromocytoma; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium; Tumor Cells, Cultured | 1999 |
Binding properties of C-truncated delta opioid receptors.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Peptide Fragments; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Mutagenesis, Site-Directed; Naloxone; Peptide Fragments; Peptides; Protein Structure, Secondary; Rats; Receptors, Opioid, mu; Somatostatin; Transfection | 1999 |
Nonselective coupling of the human mu-opioid receptor to multiple inhibitory G-protein isoforms.
Topics: Binding Sites; Binding, Competitive; Buprenorphine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Gene Expression; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Protein Binding; Protein Isoforms; Receptors, Opioid, mu; Recombinant Proteins; Saccharomyces cerevisiae; Spheroplasts; Transformation, Genetic | 1999 |
Membrane microviscosity modulates mu-opioid receptor conformational transitions and agonist efficacy.
Topics: Animals; Cell Line; Cell Membrane; Cholesterol Esters; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Fluidity; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Conformation; Rats; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Tumor Cells, Cultured; Viscosity | 1999 |
Enkephalin inhibits vagal control of heart rate, contractile force and coronary blood flow in the canine heart in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Coronary Circulation; Diprenorphine; Dogs; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Female; Heart Rate; Male; Myocardial Contraction; Narcotic Antagonists; Vagus Nerve | 1999 |
Effects of diethylstilbestrol on mouse hippocampal evoked potentials in vitro.
Topics: Animals; Binding, Competitive; Dactinomycin; Diethylstilbestrol; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Excitatory Postsynaptic Potentials; Hippocampus; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Pyramidal Cells; Receptors, Opioid; Receptors, Opioid, mu | 1999 |
Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the delta-opioid receptor.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Substitution; Animals; Aspartic Acid; Binding, Competitive; Chlorocebus aethiops; Codon; Colforsin; COS Cells; Cyclic AMP; Diprenorphine; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ligands; Mice; Mutagenesis, Site-Directed; Naloxone; Pertussis Toxin; Point Mutation; Protein Binding; Receptors, Opioid, delta; Recombinant Fusion Proteins; Second Messenger Systems; Transfection; Virulence Factors, Bordetella | 1999 |
Kappa opioids and TGFbeta1 interact in human endometrial cells.
Topics: Cells, Cultured; Diprenorphine; Dose-Response Relationship, Drug; Endometrium; Enkephalins; Female; Humans; Narcotics; Protein Precursors; Receptors, Opioid, kappa; Signal Transduction; Transforming Growth Factor beta | 2000 |
Local opiate receptors in the sinoatrial node moderate vagal bradycardia.
Topics: Animals; Blood Pressure; Bradycardia; Coronary Vessels; Diprenorphine; Dogs; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Heart Rate; Narcotic Antagonists; Norepinephrine; Receptors, Opioid; Sinoatrial Node; Sympathomimetics; Vagus Nerve | 2001 |
Alterations in cortical and basal ganglia levels of opioid receptor binding in a rat model of l-DOPA-induced dyskinesia.
Topics: Animals; Basal Ganglia; Behavior, Animal; Binding Sites; Cerebral Cortex; Diprenorphine; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Enkephalins; Female; Levodopa; Narcotic Antagonists; Oxidopamine; Protein Precursors; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Sympatholytics; Tritium | 2001 |
Opioid binding in DYT1 primary torsion dystonia: an 11C-diprenorphine PET study.
Topics: Adult; Aged; Basal Ganglia; Binding Sites; Corpus Striatum; Diprenorphine; Dystonia Musculorum Deformans; Enkephalins; Female; Gene Deletion; Humans; Male; Middle Aged; Molecular Chaperones; Positron-Emission Tomography; Severity of Illness Index | 2004 |
Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbon Isotopes; Child; Child, Preschool; Dentate Gyrus; Diprenorphine; Enkephalins; Epilepsy, Temporal Lobe; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Postmortem Changes; Protein Precursors; RNA, Messenger; Up-Regulation; Young Adult | 2009 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |