enkephalin, leucine has been researched along with colforsin in 108 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 23 (21.30) | 18.7374 |
1990's | 77 (71.30) | 18.2507 |
2000's | 6 (5.56) | 29.6817 |
2010's | 1 (0.93) | 24.3611 |
2020's | 1 (0.93) | 2.80 |
Authors | Studies |
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Gintzler, AR; Xu, H | 2 |
Eriksson, PS; Hansson, E; Rönnbäck, L | 2 |
Heller, PH; Levine, JD; Taiwo, YO | 1 |
Childers, SR; Fleming, L; Konkoy, C; Marckel, D; Pacheco, M; Sexton, T; Ward, S | 1 |
Bardin, CW; Fujisawa, M; Morris, PL | 1 |
Childers, SR; Nijssen, PC; Sexton, T | 1 |
Rengel, I; Schulz, R; Sinowatz, F | 1 |
Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
Gnegy, ME; Mangels, LA | 1 |
Bishopric, NH; Sato, B; Webster, KA | 1 |
Barthel, F; Becquet, D; Boudouresque, F; Giraud, P; Grino, M; Kowalski, C; Loeffler, JP; Renard, M | 1 |
Joshi, J; Sabol, SL | 1 |
Jessop, JJ; Taplits, MS | 1 |
Bleasdale, JE; Denlinger, LC; Fisher, SK; Mostafapour, SP; Thompson, AK | 1 |
Duan, DS; Eiger, S; Lameh, J; Sadée, W; Yu, VC | 1 |
Johnson, SM; Pillai, NP | 1 |
Chu, HM; Comb, MJ; Kobierski, LA; Tan, Y | 1 |
Batter, DK; Kessler, JA | 1 |
Dave, HP; Joshi, JB | 1 |
Mulder, AH; Schoffelmeer, AN; Wierenga, EA | 1 |
Höllt, V; Kley, N; Loeffler, JP; Pittius, CW | 1 |
Berry-Kravis, E; Dawson, G; Derechin, V; Kazmierczak, BI | 1 |
Mihara, S; North, RA; Surprenant, A | 1 |
Kew, D; Kilpatrick, DL | 1 |
Aizawa, T; Nozawa, A; Yoshikawa, K | 1 |
Cox, BM; Puttfarcken, PS | 1 |
Gintzler, AR; Smolens, I; Xu, H | 1 |
Childers, SR | 1 |
Duman, RS; Nestler, EJ; Tallman, JF | 1 |
Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
Al Zein, M; Koch, B; Lutz-Bucher, B | 1 |
Crain, B; Crain, SM; Peterson, ER | 1 |
Sabol, SL; Yoshikawa, K | 1 |
Mulder, AH; Putters, J; Schoffelmeer, AN | 1 |
Schwartz, JP | 1 |
Wilson, SP | 1 |
Beinfeld, MC; Eiden, LE; Moskal, JR; Pruss, RM | 1 |
Eiden, LE; Pruss, RM; Siegel, RE | 1 |
Kirshner, N; Viveros, OH; Wilson, SP | 1 |
Eiden, LE; Hook, VY; Pruss, RM | 1 |
Eiden, LE; Hotchkiss, AJ | 1 |
Eiden, LE; Ruth, JA | 1 |
Childers, SR; Dworkin, SI; Kluttz, BW; Vrana, KE | 1 |
Ingram, SL; Williams, JT | 1 |
Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
Knapp, RJ; Li, X; Malatynska, E; Roeske, WR; Santoro, G; Waite, S; Wang, Y; Yamamura, HI | 1 |
Chakrabarti, S; Law, PY; Loh, HH | 1 |
Cole, RL; Green, D; Grossbard, SJ; Hyman, SE; Konradi, C; Leveque, JC; Pollack, AE; Senatus, P | 1 |
Gabrilovac, J | 1 |
Inturrisi, CE; Jenab, S | 1 |
McGinty, JF; Simpson, JN | 1 |
Hong, JS; Hudson, PM; Suh, HW | 1 |
Goc, A; Hong, JS; Jiang, HK; Poisner, A; Stachowiak, EK; Stachowiak, MK | 1 |
Jauzac, P; Polastron, J | 1 |
Bare, LA; Mansson, E; Yang, D | 1 |
Law, PY; Prather, PL; Tsai, AW | 1 |
Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H | 1 |
Douglass, J; Dubner, R; Gu, J; Iadarola, MJ; Messersmith, DJ | 1 |
Brown, GP; Chien, CC; Pasternak, GW; Standifer, KM; Wahlestedt, C | 1 |
Boswell, C; Guardiola-Diaz, HM; Seasholtz, AF | 1 |
Olianas, MC; Onali, P | 1 |
Sun, X | 1 |
Bell, GI; Kong, H; Moe, ST; Portoghese, PS; Raynor, K; Reisine, T; Yasuda, K | 1 |
Côté, TE; Izenwasser, S; Weems, HB | 1 |
Dorow, J; Feller, DJ; Stuart, JF | 1 |
Han, JS; Ren, MF; Shun, XJ; Wang, JF; Yang, HF | 1 |
Avidor-Reiss, T; Bayewitch, M; Levy, R; Matus-Leibovitch, N; Nevo, I; Vogel, Z | 1 |
Hirst, RA; Lambert, DG | 1 |
Bacher, B; Höllt, V; Schulz, S; Wang, X | 1 |
Dubner, R; Gu, J; Iadarola, MJ; Kim, DJ; Messersmith, DJ | 1 |
Hong, JS; Hudson, PM; McMillian, MK; Pennypacker, KR; Sawin, SB; Simmons, KL; Suh, HH; Thai, L; Wu, GC | 1 |
George, SR; Kouvelas, A; O'Dowd, BF; Pak, Y; Rasmussen, J; Scheideler, MA | 1 |
Chan, RJ; Crabb, DW; Stewart, MJ | 1 |
Ha, TS; Kim, YH; Song, DK; Suh, HW; Wie, MB | 2 |
Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM | 1 |
Chiu, TT; Wong, YH; Yung, LY | 1 |
Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
Cai, YC; Cheng, ZJ; Fan, GH; Jiang, LZ; Ma, L; Pei, G | 1 |
Altschuld, R; Hohl, C; Lakatta, EG; Pepe, S; Xiao, RP | 1 |
Ayukawa, K; Murata, J; Ogasawara, M; Saimi, I | 1 |
Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
Höllt, V; Koch, T; Kroslak, T; Mayer, P; Raulf, E | 1 |
Georgoussi, Z; Merkouris, M; Milligan, G; Mullaney, I | 1 |
Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J | 1 |
Fukuda, K; Kato, S; Mima, H; Mori, K; Morikawa, H; Shoda, T | 2 |
Cheng, ZJ; Ma, L; Pei, G; Wu, YL; Yu, QM | 1 |
Campana, G; Di Toro, R; Murari, G; Sciarretta, V; Spampinato, S | 1 |
Clark, MJ; Liu, XY; Medzihradsky, F; Remmers, AE | 1 |
Eiden, LE; Hahm, SH; Hsu, CM | 1 |
Cassel, JA; Daubert, JD; DeHaven, RN; Gong, J; Mansson, E; Strong, JA; Yu, G; Yu, L; Yue, X; Zhang, S | 1 |
Allen, RG; Fujimoto, KI; Nelson, CS; Pellegrino, MJ; Sirianni, MJ | 1 |
Wang, HL | 1 |
Borsook, D; Hyman, SE; Kobierski, LA; Srivastava, S; Wong, AE | 1 |
Allouche, S; Hasbi, A; Homburger, V; Jauzac, P; Polastron, J | 1 |
Babey, AM; Cavalli, A; Loh, HH | 1 |
Behar, O; Borsook, D; Kobierski, LA; Lewis, S; Smirnova, O | 1 |
Carrión, AM; Ledo, F; Link, WA; Mellström, B; Naranjo, JR | 1 |
Suh, HW; Won, JS | 1 |
Campos, D; Carrión, AM; Jiménez-Díaz, L | 1 |
Carlson, RR; Dudman, JT; Konradi, C; Macías, W | 1 |
Christie, MJ; Hack, SP; Vaughan, CW | 1 |
Boda, K; Gintzler, AR; Szücs, M | 1 |
Abagyan, A; Funkelstein, L; Hook, V; Mosier, C; Toneff, T; Ziegler, M | 1 |
Chang, Y; Guan, D; Huang, R; Huang, W; Qin, K; Shi, W; Tang, F; Tang, Y; Yang, H; Yang, L; Yang, Y; Yashinov, A; Zhao, L; Zhou, H; Zhou, M | 1 |
108 other study(ies) available for enkephalin, leucine and colforsin
Article | Year |
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Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil | 1992 |
Delta and kappa opiate receptors in primary astroglial cultures. Part II: Receptor sets in cultures from various brain regions and interactions with beta-receptor activated cyclic AMP.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Animals; Astrocytes; Brain Stem; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Isoproterenol; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes | 1992 |
Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Imidodiphosphate; Analgesics; Animals; Brain; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Neurons; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; RNA, Messenger | 1992 |
A germ cell factor(s) modulates preproenkephalin gene expression in rat Sertoli cells.
Topics: Animals; Blotting, Northern; Colforsin; Cyclic AMP; Enkephalins; Follicle Stimulating Hormone; Gene Expression Regulation; In Vitro Techniques; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; RNA, Messenger; Sertoli Cells; Spermatids; Spermatocytes; Time Factors | 1992 |
Opioid-inhibited adenylyl cyclase in rat brain membranes: lack of correlation with high-affinity opioid receptor binding sites.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding Sites; Brain; Cell Membrane; Colforsin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine Triphosphate; Male; Naloxone; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sodium; Sodium Chloride; Sodium Fluoride | 1992 |
Opioid-controlled adenylate cyclase in the guinea-pig myenteric plexus is confined to nerve somata.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Myenteric Plexus; Receptors, Opioid, mu | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Cyclic AMP accumulation alters calmodulin localization in SK-N-SH human neuroblastoma cells.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Alprostadil; Analgesics; Brimonidine Tartrate; Bucladesine; Calcium; Calmodulin; Carbachol; Cell Line; Colforsin; Cyclic AMP; Cytosol; Edetic Acid; Egtazic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Quinoxalines; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1992 |
Beta-adrenergic regulation of a myocardial actin gene via a cyclic AMP-independent pathway.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Actins; Animals; Animals, Newborn; Blotting, Northern; Bucladesine; Caffeine; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Enkephalins; Gene Expression Regulation; Heart; Heart Ventricles; Isoproterenol; Kinetics; Myocardium; Nifedipine; Potassium Chloride; Propranolol; Protein Precursors; Rats; Receptors, Adrenergic, beta; RNA; RNA, Messenger; Ryanodine | 1992 |
Striatal proenkephalin turnover and gene transcription are regulated by cyclic AMP and protein kinase C-related pathways.
Topics: Animals; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Female; Immunohistochemistry; Neural Pathways; Neurons; Nucleic Acid Hybridization; Pregnancy; Protein Kinase C; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1991 |
Proenkephalin gene expression in C6 rat glioma cells: potentiation of cyclic adenosine 3',5'-monophosphate-dependent transcription by glucocorticoids.
Topics: Animals; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; Colforsin; Cyclic AMP; Dexamethasone; DNA; Drug Synergism; Enkephalins; Gene Expression; Glioma; Plasmids; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1991 |
In vitro effect of high doses of morphine on Con A induced lymphokine production.
Topics: Animals; beta-Endorphin; Cell Survival; Cells, Cultured; Clone Cells; Colforsin; Concanavalin A; Cyclic AMP; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Enkephalins; Female; Lymphocyte Activation; Lymphokines; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Protein Biosynthesis; Receptors, Opioid; Spleen; T-Lymphocytes, Helper-Inducer | 1991 |
The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.
Topics: Alprostadil; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrenes; GTP-Binding Proteins; Humans; Inositol; Kinetics; Neuroblastoma; Oxotremorine; Phosphatidylinositols; Pyrrolidinones; Receptors, Muscarinic; Scopolamine; Type C Phospholipases | 1991 |
Opioids can produce a concentration-dependent naloxone-reversible enhancement of inhibition of evoked enkephalin release.
Topics: Analgesics; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Naloxone; Narcotics; Parasympatholytics; Sufentanil; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Morphine; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Theophylline; Vasoactive Intestinal Peptide | 1990 |
Hyperpolarization of myenteric neurons by opioids does not involve cyclic adenosine-3',5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Neurons | 1990 |
cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Colforsin; Cyclic AMP; Enhancer Elements, Genetic; Enkephalins; Gene Expression Regulation; Genes, fos; Glioma; Humans; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Protein Biosynthesis; Protein Kinases; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reticulocytes; Second Messenger Systems; Transcriptional Activation; Transfection | 1991 |
Region-specific regulation of preproenkephalin mRNA in cultured astrocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astrocytes; Blotting, Northern; Brain; Cells, Cultured; Cerebral Cortex; Colforsin; Corpus Striatum; Enkephalins; Hypothalamus; Isoproterenol; Protein Precursors; Rats; RNA; RNA, Messenger | 1991 |
Transactivation of the proenkephalin gene promoter by the Tax1 protein of human T-cell lymphotropic virus type I.
Topics: Animals; Colforsin; DNA Mutational Analysis; Enkephalins; Gene Expression Regulation; Gene Products, tax; Human T-lymphotropic virus 1; In Vitro Techniques; Promoter Regions, Genetic; Protein Precursors; Rats; RNA, Messenger; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1992 |
Opiate receptors in neuronal primary cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fetus; Morphine; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Role of adenylate cyclase in presynaptic alpha 2-adrenoceptor- and mu-opioid receptor-mediated inhibition of [3H]noradrenaline release from rat brain cortex slices.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cadmium; Calcimycin; Cerebral Cortex; Clonidine; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Norepinephrine; Phentolamine; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Rolipram | 1986 |
Involvement of ion channels in the induction of proenkephalin A gene expression by nicotine and cAMP in bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Glands; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Colforsin; Cyclic AMP; Enkephalins; Gallopamil; Gene Expression Regulation; Ion Channels; Nicotine; Nifedipine; Protein Precursors; RNA, Messenger; Sodium; Tubocurarine; Verapamil | 1987 |
Neuromodulator-mediated phosphorylation of specific proteins in a neurotumor hybrid cell line (NCB-20).
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Alprostadil; Animals; Brain; Calcimycin; Colforsin; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Immunoassay; Mice; Nerve Tissue Proteins; Neuroblastoma; Neurotransmitter Agents; Phosphoproteins; Phosphorylation; Protein Kinases; Serotonin; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1988 |
Somatostatin increases an inwardly rectifying potassium conductance in guinea-pig submucous plexus neurones.
Topics: Action Potentials; Animals; Cesium; Colforsin; Enkephalins; Guinea Pigs; In Vitro Techniques; Ion Channels; Naloxone; Neurons; Norepinephrine; Potassium; Rubidium; Somatostatin; Submucous Plexus; Thionucleotides; Time Factors | 1987 |
Expression and regulation of the proenkephalin gene in rat Sertoli cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Colforsin; Dihydrotestosterone; Enkephalins; Follicle Stimulating Hormone; Gene Expression Regulation; Male; Protein Precursors; Rats; RNA; Sertoli Cells; Testosterone; Time Factors | 1989 |
Phorbol ester regulates the abundance of enkephalin precursor mRNA but not of amyloid beta-protein precursor mRNA in rat testicular peritubular cells.
Topics: Amyloid; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Enkephalins; Gene Expression Regulation; Male; Protein Precursors; Rats; RNA, Messenger; Testis; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Morphine-induced desensitization and down-regulation at mu-receptors in 7315C pituitary tumor cells.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Morphine; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1989 |
Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.
Topics: Action Potentials; Animals; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Myenteric Plexus; Naloxone; Sufentanil | 1989 |
Opiate-inhibited adenylate cyclase in rat brain membranes depleted of Gs-stimulated adenylate cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Membrane; Cholera Toxin; Colforsin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; Male; Naloxone; Oligopeptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Fluoride; Virulence Factors, Bordetella | 1988 |
Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Locus Coeruleus; Male; Morphine; Narcotics; Neurons; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors; Virulence Factors, Bordetella | 1988 |
Sodium dependent 3H-noradrenaline release from rat neocortical slices in the absence of extracellular calcium: presynaptic modulation by mu-opioid receptor and adenylate cyclase activation.
Topics: Adenylyl Cyclases; Animals; Calcium; Cerebral Cortex; Colforsin; Desipramine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Extracellular Space; Male; Norepinephrine; Ouabain; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium; Veratrine | 1988 |
Modulation by Leu-enkephalin of peptide release from perifused neurointermediate pituitary. II. Inhibition of calcium-mediated secretion of alpha-MSH and beta-endorphin.
Topics: Animals; beta-Endorphin; Calcimycin; Calcium; Colforsin; Corticotropin-Releasing Hormone; Endorphins; Enkephalin, Leucine; Isoproterenol; Male; Melanocyte-Stimulating Hormones; Pituitary Gland, Posterior; Potassium; Rats; Rats, Inbred Strains; Veratridine | 1986 |
Cyclic AMP or forskolin rapidly attenuates the depressant effects of opioids on sensory-evoked dorsal-horn responses in mouse spinal cord-ganglion explants.
Topics: Animals; Bucladesine; Colforsin; Cyclic AMP; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Mice; Morphine; Organ Culture Techniques; Spinal Cord | 1986 |
Glucocorticoids and cyclic AMP synergistically regulate the abundance of preproenkephalin messenger RNA in neuroblastoma-glioma hybrid cells.
Topics: Base Sequence; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Glioma; Glucocorticoids; Hybrid Cells; Neuroblastoma; Protein Precursors; RNA, Messenger | 1986 |
Activation of presynaptic alpha 2-adrenoceptors attenuates the inhibitory effect of mu-opioid receptor agonists on noradrenaline release from brain slices.
Topics: Animals; Brain Chemistry; Cadmium; Clonidine; Colforsin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu | 1986 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Reserpine increases chromaffin cell enkephalin stores without a concomitant decrease in other proenkephalin-derived peptides.
Topics: Adrenal Glands; Animals; Cattle; Chromaffin System; Chromatography, High Pressure Liquid; Colforsin; Enkephalins; Molecular Weight; Peptide Fragments; Protein Precursors; Radioligand Assay; Reserpine; Tetrabenazine; Theophylline | 1987 |
Specific regulation of vasoactive intestinal polypeptide biosynthesis by phorbol ester in bovine chromaffin cells.
Topics: Animals; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Colforsin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Peptide Biosynthesis; Peptide PHI; Phorbols; Protein Precursors; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Vasoactive Intestinal Peptide | 1985 |
Multiple populations of neuropeptide-containing cells in cultures of the bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Catecholamines; Cattle; Cells, Cultured; Colforsin; Diterpenes; Enkephalin, Leucine; Enkephalin, Methionine; Fluorescent Antibody Technique; In Vitro Techniques; Nerve Tissue Proteins; Phenylethanolamine N-Methyltransferase; Radioimmunoassay; Vasoactive Intestinal Peptide | 1985 |
Relationship between the regulation of enkephalin-containing peptide and dopamine beta-hydroxylase levels in cultured adrenal chromaffin cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Medulla; Animals; Cattle; Cell Fractionation; Cells, Cultured; Chromaffin Granules; Colforsin; Dopamine beta-Hydroxylase; Enkephalins; Insulin; Kinetics; Peptides; Subcellular Fractions; Tetrabenazine; Theophylline | 1985 |
Selective regulation of carboxypeptidase peptide hormone-processing enzyme during enkephalin biosynthesis in cultured bovine adrenomedullary chromaffin cells.
Topics: Adrenal Medulla; Animals; Carboxypeptidases; Cattle; Cells, Cultured; Chromaffin Granules; Colforsin; Diterpenes; Enkephalin, Methionine; Enkephalins; Kinetics; Peptides; Reserpine | 1985 |
Cyclic adenosine monophosphate regulates vasoactive intestinal polypeptide and enkephalin biosynthesis in cultured bovine chromaffin cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Medulla; Animals; Bucladesine; Cardiotonic Agents; Cattle; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Enkephalins; Kinetics; Vasoactive Intestinal Peptide | 1983 |
Leucine-enkephalin modulation of catecholamine positive chronotropy in rat atria is receptor-specific and calcium-dependent.
Topics: Animals; Calcium; Catecholamines; Colforsin; Diterpenes; Enkephalin, Leucine; Heart; Heart Rate; Isoproterenol; Male; Naloxone; Norepinephrine; Rats; Receptors, Adrenergic | 1984 |
Effects of morphine on forskolin-stimulated pro-enkephalin mRNA levels in rat striatum: a model for acute and chronic opioid actions in brain.
Topics: Analgesics; Animals; Colforsin; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Male; Models, Molecular; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1995 |
Opioid inhibition of Ih via adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cations; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ion Channels; Neurons; Nodose Ganglion | 1994 |
Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Amino Acid Sequence; Cell Line; Colforsin; Culture Media, Conditioned; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Receptors, Opioid, delta | 1995 |
Human delta opioid receptor: a stable cell line for functional studies of opioids.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins | 1995 |
Neuroblastoma Neuro2A cells stably expressing a cloned mu-opioid receptor: a specific cellular model to study acute and chronic effects of morphine.
Topics: Analgesics; Animals; Binding, Competitive; Cell Line; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Mice; Models, Biological; Morphine; Neuroblastoma; Receptors, Opioid, mu; Time Factors | 1995 |
Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Sequence; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enhancer Elements, Genetic; Enkephalins; Fetus; Genes, fos; Molecular Sequence Data; Phosphorylation; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Transcription Factor AP-1 | 1995 |
Leu-enkephalin modulates the migration inhibition of mouse splenocytes induced by cAMP-elevating agents.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Migration Inhibition; Cell Movement; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; In Vitro Techniques; Mice; Mice, Inbred CBA; Naloxone; Spleen; Theophylline | 1993 |
Proenkephalin gene expression: interaction of glucocorticoid and cAMP regulatory elements.
Topics: Animals; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Dexamethasone; DNA; Enkephalins; Gene Expression Regulation; Plasmids; Promoter Regions, Genetic; Protein Precursors; Rats; Receptors, Glucocorticoid; Tumor Cells, Cultured | 1995 |
Forskolin induces preproenkephalin and preprodynorphin mRNA in rat striatum as demonstrated by in situ hybridization histochemistry.
Topics: Animals; Colforsin; Corpus Striatum; Dynorphins; Enkephalins; Histocytochemistry; In Situ Hybridization; Injections, Intraventricular; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Expression of the proenkephalin A gene and [Met5]-enkephalin secretion induced by arachidonic acid in bovine adrenal medullary chromaffin cells: involvement of second messengers.
Topics: Adrenal Medulla; Animals; Arachidonic Acid; Base Sequence; Calcium Channel Blockers; Calmodulin; Cattle; Cells, Cultured; Chromaffin System; Colforsin; Enkephalin, Methionine; Enkephalins; Gene Expression; Imidazoles; Molecular Probes; Molecular Sequence Data; Protein Kinase C; Protein Precursors; RNA, Messenger; Second Messenger Systems; Sphingosine | 1995 |
Regulation of tyrosine hydroxylase gene expression in depolarized non-transformed bovine adrenal medullary cells: second messenger systems and promoter mechanisms.
Topics: Adrenal Medulla; Animals; Calmodulin; Cattle; Colforsin; Enkephalins; Gene Expression Regulation, Enzymologic; Membrane Potentials; Phenylethanolamine N-Methyltransferase; Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; RNA, Messenger; Second Messenger Systems; Transcriptional Activation; Tyrosine 3-Monooxygenase; Veratridine | 1994 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; CHO Cells; Colforsin; Cricetinae; Diprenorphine; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Genetic Variation; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Receptors, Opioid, mu; RNA, Messenger; Transfection | 1994 |
Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Cell Differentiation; Colforsin; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Neuroblastoma; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Tumor Cells, Cultured | 1994 |
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 1994 |
Basal and inducible transcriptional activity of an upstream AP-1/CRE element (DYNCRE3) in the prodynorphin promoter.
Topics: Animals; Base Sequence; Colforsin; Cyclic AMP; Enkephalins; Gene Expression Regulation; HeLa Cells; Humans; Molecular Sequence Data; PC12 Cells; Plasmids; Promoter Regions, Genetic; Protein Precursors; Rats; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1994 |
Selective loss of delta opioid analgesia and binding by antisense oligodeoxynucleotides to a delta opioid receptor.
Topics: Adenylyl Cyclases; Analgesia; Animals; Base Sequence; Binding Sites; Cell Line; Colforsin; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Receptors, Opioid, delta; Tritium | 1994 |
The cAMP-responsive element in the corticotropin-releasing hormone gene mediates transcriptional regulation by depolarization.
Topics: Animals; Base Sequence; Calcium; Calcium Channels; Calmodulin; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; DNA; Enkephalins; Gene Expression Regulation; Humans; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Insertional; Oligodeoxyribonucleotides; PC12 Cells; Plasmids; Potassium; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Restriction Mapping; Transcription, Genetic; Transfection | 1994 |
Activation of opioid and muscarinic receptors stimulates basal adenylyl cyclase but inhibits Ca2+/calmodulin- and forskolin-stimulated enzyme activities in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Carbachol; Colforsin; Enkephalin, Leucine; Fluorides; Male; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Opioid | 1994 |
[The influence of DPDPE on intracellular free calcium concentration induced by Bt2 cAMP and phorbol ester].
Topics: Calcium-Transporting ATPases; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1993 |
A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.
Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Colforsin; Cyclic AMP; Enkephalins; Guanosine Triphosphate; In Vitro Techniques; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Narcotics; Oligodeoxyribonucleotides; Protein Binding; Receptors, Opioid, delta; Recombinant Proteins; Signal Transduction; Sodium; Structure-Activity Relationship | 1993 |
Naltrexone-induced upregulation of mu opioid receptors on 7315c cell and brain membranes: enhancement of opioid efficacy in inhibiting adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Membrane; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Naltrexone; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation | 1993 |
Mu-opiate receptor binding and function in HOT and COLD selected lines of mice.
Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Body Temperature; Brain; Brain Chemistry; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethanol; Female; Levorphanol; Male; Mice; Mice, Inbred Strains; Naloxone; Nerve Tissue Proteins; Receptors, Opioid, mu | 1993 |
Suppression by [D-Pen2, D-Pen5]enkephalin on cyclic AMP dependent protein kinase-induced, but not protein kinase C-induced increment of intracellular free calcium in NG108-15 cells.
Topics: Analgesics; Animals; Bucladesine; Calcium; Calcium Channels; Colforsin; Depression, Chemical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Hybrid Cells; Intracellular Fluid; Mice; Neuroblastoma; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, Opioid, delta; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics; Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Morphine; Naloxone; Pertussis Toxin; Phosphodiesterase Inhibitors; Rats; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1995 |
Do SH-SY5Y human neuroblastoma cells express cannabinoid receptors?
Topics: Adenylyl Cyclase Inhibitors; Cannabinoids; Colforsin; Cyclic AMP; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Neuroblastoma; Potassium; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Tumor Cells, Cultured | 1995 |
Induction of proenkephalin gene expression in cultured bovine chromaffin cells is dependent on protein synthesis of AP-1 proteins.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cattle; Cells, Cultured; Chromaffin System; Colforsin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enkephalins; Gene Expression Regulation; Genes, Immediate-Early; Genes, Reporter; Kinetics; Molecular Sequence Data; Nuclear Proteins; Oligonucleotides; Peptide Fragments; Phosphorylation; Potassium Chloride; Protein Kinase C; Protein Precursors; Proto-Oncogene Proteins c-fos; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1 | 1996 |
c-Jun activation of the DYNCRE3 site in the prodynorphin promoter.
Topics: Animals; Base Sequence; Binding Sites; Chloramphenicol O-Acetyltransferase; Colforsin; Consensus Sequence; Cyclic AMP Response Element-Binding Protein; Enkephalins; Genes, Reporter; Molecular Sequence Data; Oligodeoxyribonucleotides; PC12 Cells; Promoter Regions, Genetic; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Recombinant Proteins; Transcription Factor AP-1; Transcription, Genetic; Transfection | 1996 |
Dexamethasone and forskolin synergistically increase [Met5]enkephalin accumulation in mixed brain cell cultures.
Topics: Animals; Astrocytes; Brain; Cells, Cultured; Colforsin; Dexamethasone; Drug Combinations; Drug Synergism; Enkephalin, Methionine; Enkephalins; Glucocorticoids; Neuroglia; Neurons; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Glucocorticoid; RNA, Messenger | 1996 |
Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.
Topics: Analgesics; Animals; Binding Sites; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Kidney; Kinetics; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Sensitivity and Specificity; Stimulation, Chemical; Transfection | 1996 |
Dexamethasone represses phorbol ester-, forskolin-, and calcium-stimulated expression of a preproenkephalin A promoter-chloramphenicol acetyltransferase gene via a receptor-mediated mechanism.
Topics: Calcimycin; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Depression, Chemical; Dexamethasone; Enkephalins; Gene Expression Regulation, Enzymologic; Genes, Reporter; Glucocorticoids; Humans; Ionophores; Promoter Regions, Genetic; Protein Precursors; Receptors, Glucocorticoid; Tetradecanoylphorbol Acetate | 1996 |
Molecular mechanisms underlying the regulation of proenkephalin gene expression in cultured spinal cord cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Mollusk Venoms; Nimodipine; Protein Kinase C; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Signal Transduction; Spinal Cord; Tetradecanoylphorbol Acetate | 1996 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Haloperidol; Humans; Kinetics; Morphine; Naloxone; Neuroblastoma; Pentazocine; Phosphatidylinositols; Receptors, Opioid; Receptors, sigma; Trypsin; Tumor Cells, Cultured | 1996 |
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation.
Topics: Cell Line; Colforsin; Cyclic AMP; Drug Interactions; Enkephalin, Leucine; Humans; Narcotic Antagonists; Receptors, Opioid, delta | 1996 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Naltrexone; Narcotic Antagonists; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1997 |
'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart.
Topics: Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Animals; Blood Pressure; Colforsin; Cyclic AMP; Enkephalin, Leucine; Ethanolamines; GTP-Binding Proteins; Heart; Male; Myocardium; Naloxone; Narcotic Antagonists; Norepinephrine; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Opioid, delta; Sarcolemma; Second Messenger Systems; Systole; Thionucleotides; Ventricular Function, Left; Virulence Factors, Bordetella | 1997 |
Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro.
Topics: Adenocarcinoma; Animals; Biocompatible Materials; Calcitonin Gene-Related Peptide; Cell Division; Cell Movement; Colforsin; Collagen; Colonic Neoplasms; Dideoxyadenosine; Dose-Response Relationship, Drug; Drug Combinations; Enkephalins; Laminin; Leucine; Mice; Neoplasm Invasiveness; Neurokinin A; Neuropeptide Y; Neuropeptides; Proteoglycans; Somatostatin; Substance P; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1997 |
The regulation of prodynorphin gene expression in cultured spinal cord cells: involvement of second messengers.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Embryo, Mammalian; Enkephalins; Kinetics; Neurons; Protein Kinase C; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Spinal Cord; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 1997 |
Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Mutagenesis, Site-Directed; Mutation; Oocytes; Rats; Receptors, Opioid, mu; Xenopus laevis | 1997 |
Regulation of spontaneous activity of the delta-opioid receptor: studies of inverse agonism in intact cells.
Topics: Adenine; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cholera Toxin; Clone Cells; Colforsin; Cyclic AMP; Electrophysiology; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Mice; Naloxone; Narcotic Antagonists; Pertussis Toxin; Rats; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1997 |
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine | 1997 |
Adaptations to chronic agonist exposure of mu-opioid receptor-expressing Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Receptors, Opioid, mu | 1998 |
Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Naloxone; Receptors, Cell Surface; Receptors, Opioid; Transfection | 1998 |
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection | 1998 |
Regulation of delta opioid receptors by delta9-tetrahydrocannabinol in NG108-15 hybrid cells.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Leucine; Glioma; Mice; Neuroblastoma; Piperidines; Pyrazoles; Rats; Receptors, Opioid, delta; Rimonabant; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Delta opioid receptor down-regulation is independent of functional G protein yet is dependent on agonist efficacy.
Topics: Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Rats; Receptors, Opioid; Tumor Cells, Cultured | 1998 |
PACAP activates calcium influx-dependent and -independent pathways to couple met-enkephalin secretion and biosynthesis in chromaffin cells.
Topics: Adrenal Glands; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Signaling; Cattle; Chromaffin Cells; Colforsin; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Male; Models, Biological; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium; Protein Precursors; Radioimmunoassay; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1998 |
Endomorphins fully activate a cloned human mu opioid receptor.
Topics: Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Humans; Oligopeptides; Oocytes; Potassium Channels; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Xenopus | 1998 |
Cyclic AMP analogs induce synthesis, processing, and secretion of prepro nociceptin/orphanin FQ-derived peptides by NS20Y neuroblastoma cells.
Topics: Animals; Cell Size; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Narcotics; Neurites; Neuroblastoma; Neurons; Nociceptin; Opioid Peptides; Peptide Fragments; Radioimmunoassay; Receptors, Opioid, delta; RNA, Messenger; Signal Transduction; Thionucleotides; Time Factors; Tumor Cells, Cultured | 1999 |
A conserved arginine in the distal third intracellular loop of the mu-opioid receptor is required for G protein activation.
Topics: Adenylyl Cyclases; Animals; Arginine; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Humans; Kidney; Ligands; Mutation; Radioligand Assay; Rats; Receptors, Opioid, mu | 1999 |
Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase.
Topics: Animals; Animals, Newborn; Astrocytes; Benzoquinones; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enhancer Elements, Genetic; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Lactams, Macrocyclic; Phosphorylation; Phosphoserine; Promoter Regions, Genetic; Protein Precursors; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; src-Family Kinases; Transfection | 1999 |
Differential G-protein activation by alkaloid and peptide opioid agonists in the human neuroblastoma cell line SK-N-BE.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Animals; Azides; Cell Membrane; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Isoelectric Point; Neuroblastoma; Neurons; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Peptides; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the delta-opioid receptor.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Substitution; Animals; Aspartic Acid; Binding, Competitive; Chlorocebus aethiops; Codon; Colforsin; COS Cells; Cyclic AMP; Diprenorphine; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ligands; Mice; Mutagenesis, Site-Directed; Naloxone; Pertussis Toxin; Point Mutation; Protein Binding; Receptors, Opioid, delta; Recombinant Fusion Proteins; Second Messenger Systems; Transfection; Virulence Factors, Bordetella | 1999 |
PhosphoCREB and CREM/ICER: positive and negative regulation of proenkephalin gene expression in the paraventricular nucleus of the hypothalamus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Galactosidase; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Enkephalins; Escherichia coli; Gene Expression Regulation; Interleukin-1; Kinetics; Lipopolysaccharides; Male; Mice; Mice, Transgenic; Muscimol; Neurons; Paraventricular Hypothalamic Nucleus; Phosphorylation; Protein Precursors; Recombinant Proteins; Repressor Proteins; RNA, Messenger; Transcription, Genetic | 1999 |
DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.
Topics: Amino Acid Motifs; Amino Acid Sequence; Calcium; Calcium-Binding Proteins; Cell Line; Colforsin; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enkephalins; Gene Expression Regulation; Genes, Regulator; Genes, Reporter; Humans; Kv Channel-Interacting Proteins; Molecular Sequence Data; Mutation; Neuroblastoma; Phosphorylation; Protein Precursors; Recombinant Proteins; Repressor Proteins; RNA, Messenger; Sequence Alignment; Transfection; Tumor Cells, Cultured | 2000 |
The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes.
Topics: Animals; Astrocytes; Blotting, Western; Cells, Cultured; Colforsin; Cyclic AMP Response Element-Binding Protein; Dexamethasone; DNA; Enkephalins; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Response Elements; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 2000 |
Ca(2+)-dependent prodynorphin transcriptional derepression in neuroblastoma cells is exerted through DREAM protein activity in a kinase-independent manner.
Topics: Animals; Caffeine; Calcium; Calcium Signaling; Calcium-Binding Proteins; Central Nervous System; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Genes, Regulator; Humans; Kv Channel-Interacting Proteins; Mutation; Neuroblastoma; Neurons; Protein Biosynthesis; Protein Precursors; Repressor Proteins; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antihypertensive Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Drug Interactions; Embryo, Mammalian; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Isoquinolines; Neurons; Nifedipine; Protein Precursors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection | 2003 |
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro.
Topics: Action Potentials; Adenosine; Affinity Labels; Animals; Colforsin; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Enkephalins; Enzyme Inhibitors; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Probenecid; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Substance Withdrawal Syndrome; Sulfonamides; Synaptic Transmission; Thioinosine; Time Factors; Uricosuric Agents; Vasodilator Agents; Xanthines | 2003 |
Dual effects of DAMGO [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) on adenylyl cyclase activity: implications for mu-opioid receptor Gs coupling.
Topics: Adenylyl Cyclases; Animals; CHO Cells; Colforsin; Cricetinae; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; GTP-Binding Protein alpha Subunits, Gs; Narcotics; Peptide Fragments; Peptides; Pertussis Toxin; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 2004 |
Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Dopamine; Enkephalins; Epinephrine; Galanin; Ganglionic Stimulants; Humans; Neuroblastoma; Neurons; Neuropeptide Y; Neuropeptides; Neurotransmitter Agents; Nicotine; Norepinephrine; Peptide Fragments; Secretory Vesicles | 2013 |
Selective N-glycan editing on living cell surfaces to probe glycoconjugate function.
Topics: Animals; Cell Line, Tumor; Cell Membrane; CHO Cells; Colforsin; Cricetulus; Enkephalin, Leucine; Epithelial Cells; Gene Expression; Glycoconjugates; Glycosylation; HEK293 Cells; Humans; Mice; Oligosaccharides; Protein Multimerization; Protein Transport; Receptors, Opioid, delta; Transgenes | 2020 |