enkephalin, leucine and cocaine

enkephalin, leucine has been researched along with cocaine in 104 studies

Research

Studies (104)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (2.88)	18.7374
1990's	52 (50.00)	18.2507
2000's	35 (33.65)	29.6817
2010's	9 (8.65)	24.3611
2020's	5 (4.81)	2.80

Authors

Authors	Studies
Branch, AD; Kreek, MJ; Lee, SE; Unterwald, EM	1
Herkenham, M; Hurd, YL	3
Horne-King, J; Kreek, MJ; Unterwald, EM	1
Billings, B; Candido, J; Duttaroy, A; Lutfy, K; Sierra, V; Yoburn, BC; Zito, SW	1
Brown, EE; Fibiger, HC; Finlay, JM; Gerfen, CR; Hurd, YL	1
Cohen, BM; Hyman, SE; Nguyen, TV	1
Chiba, S; Nishida, N	1
Marshall, KC; Williams, JT	1
DuMars, LA; Kalivas, PW; Rodger, LD	1
Ku, PY; Lee, HK; Yen, MH	1
Gerfen, CR; Steiner, H	1
Fredholm, BB; Johansson, B; Lindström, K	1
Daunais, JB; McGinty, JF	2
Guminski, BJ; Hooks, MS; Kalivas, PW; Sorg, BA	1
Daunais, JB; McGinty, JF; Roberts, DC	1
Keller, RW; Snyder-Keller, AM	1
Kreek, MJ; Spangler, R; Unterwald, EM	1
Kreek, MJ; Rubenfeld, JM; Unterwald, EM	1
Ho, A; Kreek, MJ; Maisonneuve, IM	1
Daunais, JB; Helton, TE; McGinty, JF	1
Kameyama, T; Mizutani, M; Ukai, M	1
Lasoń, W; Machelska, H; Przewłocka, B; Przewłocki, R	1
Cote, TE; Cox, BM; Izenwasser, S; Kreek, MJ; Unterwald, EM	1
Kameyama, T; Mori, E; Ukai, M	1
Caron, MG; Giros, B; Jaber, M; Jones, SR; Wightman, RM	1
Cox, BM; Donatini, A; Ferri, S; Izenwasser, S; Romualdi, P	1
Cox, BM; Heller, B; Izenwasser, S	1
Drago, J; Gerfen, CR; Steiner, H; Westphal, H	1
Ho, A; Kreek, MJ; Maggos, CE; Spangler, R; Zhou, Y; Zlobin, A	1
Chai, L; Choi, WS; Rönnekleiv, OK	1
Lasoń, W; Przewłocka, B	1
Ho, A; Kreek, MJ; Maggos, CE; Schlussman, SD; Spangler, R; Zhou, Y	1
Kishimoto, Y; Maeda, J; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M	1
Daunais, JB; Nader, MA; Porrino, LJ	1
Gerfen, CR; Keefe, KA; Steiner, H	1
Daunais, JB; Davies, HM; Hart, SL; Hedgecock-Rowe, A; Matasi, JJ; Porrino, LJ; Thornley, C	1
Besson, MJ; Mathieu-Kia, AM	1
Bhargava, HN; Cao, YJ	1
Hurd, YL; Svensson, P	1
Chai, L; Choi, WS; Fang, Y; Rønnekleiv, OK	1
Azaryan, AV; Clock, BJ; Cox, BM; Rosenberger, JG	1
Lasoń, W; Przewłocka, B; Przewłocki, R; Turchan, J	1
Dow-Edwards, DL; Hurd, YL	1
DeMontis, MG; Dworkin, SI; Kim, SA; Martin, TJ; Sizemore, GM; Smith, JE	1
Holtzman, SG; Waddell, AB	1
Cappendijk, SL; Hurd, YL; Nylander, I; Terenius, L; van Ree, JM	1
Adamson, KL; Chow, BL; Coen, KM; Corrigall, WA	2
Alonso, R; Fournier, M; Fréchin, N; Gnanadicom, H; Le Fur, G; Soubrié, P	1
Duffy, P; Kalivas, PW; Mackler, SA	1
Fagergren, P; Hurd, YL	1
Lucas, LR; McEwen, BS; Pompei, P	1
Brené, S; Olson, L; Thorén, P; Werme, M	1
Adams, DH; Hanson, GR; Keefe, KA	1
Arroyo, M; Baker, WA; Everitt, BJ	1
Cox, BM; D'Addario, C; Ferri, S; Izenwasser, S; Romualdi, P	1
Alvarez Fischer, D; Ferger, B; Gross, S; Kuschinsky, K; Schäfer, MK; Weihe, E; Westermann, R	1
Ambrosio, E; Corchero, J; Crespo, JA; Manzanares, J; Oliva, JM; Palomo, T	1
Ho, A; Jeanne Kreek, M; Spangler, R; Zhou, Y	1
Andersson, M; Cenci, MA; Konradi, C	1
Ho, A; Kreek, MJ; Schlussman, SD; Sora, I; Spangler, R; Uhl, GR; Yuferov, VP; Zhou, Y	1
Hurd, YL	1
Ho, A; Jeanne Kreek, M; LaForge, KS; Nyberg, F; Yuferov, V; Zhou, Y	1
Ho, A; Kreek, MJ; Schlussman, SD; Spangler, R; Zhou, Y	1
Andersson, M; Cenci, MA; Westin, JE	1
Freeman, AY; Pierce, RC; Soghomonian, JJ	1
Ho, A; Kreek, MJ; Spangler, R; Zhou, Y	1
Daunais, JB; Fagergren, P; Hurd, YL; Nader, MA; Porrino, LJ; Smith, HR	1
Chavkin, C; Marton-Popovici, M; McLaughlin, JP	1
Brandon, CL; Steiner, H	1
Candeletti, S; Collins, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P	1
Ho, A; Kreek, MJ; Mantsch, JR; Mathieu-Kia, AM; Yuferov, V	1
Candeletti, S; D'Addario, C; Di Benedetto, M; Feliciani, D; Izenwasser, S; Romualdi, P	1
Batt, AM; Becuwe, P; Dauça, M; Ferrari, L; Lambert, H; Malaplate-Armand, C; Masson, C; Visvikis, S	1
Fagergren, P; Goiny, M; Hurd, YL; Overstreet, DH	1
Alvaro, JD; Duman, RS; Haile, C; Han, G; Hruby, VJ; Hsu, R; Nestler, EJ; Newton, SS; Taylor, JR	1
Bailey, A; Bendor, J; Ho, A; Kreek, MJ; Schlussman, SD; Yuferov, V; Zhou, Y	1
Chavkin, C; Chavkin, TA; Li, S; McLaughlin, JP; Valdez, J	1
Chavkin, C; Land, BB; Li, S; McLaughlin, JP; Pintar, JE	1
Deroche-Gamonet, V; Izawa, R; Jaber, M; Kellendonk, C; Le Moal, M; Piazza, PV; Sillaber, I; Tronche, F	1
Steiner, H; Willuhn, I	1
Brambilla, R; Fasano, S; Ferguson, SM; Robinson, TE; Yang, P	1
Kostowski, W; Mierzejewski, P; Przewłocki, R; Stefański, R; Zapart, G; Ziółkowska, B	1
Hope, BT; Kreuter, JD; Mattson, BJ; Mitchell, TB; Simmons, DE	1
Candeletti, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P	1
Hubert, GW; Kuhar, MJ	1
Dow-Edwards, DL; Hurd, YL; Torres-Reveron, A	1
Di Paolo, T; Grégoire, L; Lévesque, D; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P; Tamim, MK	1
Andersen, ML; Bicocchi, ES; Chagas, JR; Dalio, FM; Ferro, ES; Freua, R; Gesteira, TF; Machado, MF; Nader, HB; Oliveira, V; Perry, JC; Toledo, CA; Tufik, S; Visniauskas, B	1
Butelman, ER; Ho, A; Kreek, MJ; Schlussman, SD; Zhang, Y	1
Courade, JP; Cuvelier, L; Dardou, D; De Ryck, M; Foerch, P; Monlezun, S; Schiffmann, SN	1
Bannerman, DM; Besusso, D; Calabresi, P; Geibel, M; Kramer, D; Minichiello, L; Pendolino, V; Picconi, B; Schneider, T	1
Bastias del Carmen Candia, S; Candeletti, S; Caputi, FF; Carretta, D; Cavina, C; D'Addario, C; Di Benedetto, M; Romualdi, P	1
Cohen, A; Contet, C; George, O; Kieffer, BL; Koebel, P; Koob, GF; Kreifeldt, M; Whitfield, TW	1
Burokas, A; Gutiérrez-Cuesta, J; Kummer, S; Maldonado, R; Mancino, S; Martín-García, E	1
Assis, MA; Cancela, LM; García-Keller, C; Mascó, DH; Mongi-Bragato, B; Virgolini, MB; Zamponi, E; Zimmer, A	1
Chen, R; Kind, KO; Luessen, DJ; Sun, H; Zhang, K	1
Avalos, MP; Bollati, FA; Cancela, LM; García-Keller, C; Guzmán, AS; Mongi-Bragato, B	1
Graham, DP; Hamon, SC; Hillhouse, M; Kosten, TR; Lawson, WB; Ling, W; Nielsen, DA; Nielsen, EM; Rotrosen, J; Saxon, AJ; Settles-Reaves, BD; Shmueli-Blumberg, D; Shores-Wilson, K; Trivedi, MH; Walker, R	1
Alvarez, VA; Blegen, MB; Bocarsly, ME; Choi, IB; Dai, KZ; Dobbs, LK; Kaplan, AR; Kellendonk, C; Levitt, R; Matsui, A; Shin, JH; Simpson, EH	1
Asokan, M; Choi, IB; Dobbs, LK; Le, NN; Matsumura, K; Natividad, LA; Nicot, A	1

Trials

1 trial(s) available for enkephalin, leucine and cocaine

Article	Year
Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene. European journal of clinical pharmacology, 2022, Volume: 78, Issue:6 Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Enkephalins; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Protein Precursors	2022

Article

Year

Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.

European journal of clinical pharmacology, 2022, Volume: 78, Issue:6

Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Enkephalins; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Protein Precursors

2022

Other Studies

103 other study(ies) available for enkephalin, leucine and cocaine

Article	Year
Quantitation of preproenkephalin mRNA levels in brain regions from male Fischer rats following chronic cocaine treatment using a recently developed solution hybridization assay. Brain research. Molecular brain research, 1992, Volume: 14, Issue:3 Topics: Animals; Blotting, Northern; Brain; Cocaine; Drug Administration Schedule; Enkephalins; Injections, Intraperitoneal; Male; Organ Specificity; Protein Precursors; Rats; Rats, Inbred F344; RNA; RNA, Messenger; Time Factors	1992
Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal neuropeptides. Brain research. Molecular brain research, 1992, Volume: 16, Issue:1-2 Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; In Situ Hybridization; Male; Neuropeptides; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P	1992
Chronic cocaine alters brain mu opioid receptors. Brain research, 1992, Jul-03, Volume: 584, Issue:1-2 Topics: Animals; Autoradiography; Brain; Brain Chemistry; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Rats; Receptors, Opioid; Receptors, Opioid, mu; Up-Regulation	1992
Potentiation of opioid analgesia by cocaine: the role of spinal and supraspinal receptors. Life sciences, 1992, Volume: 50, Issue:8 Topics: Analgesics, Opioid; Animals; Brain; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Receptors, Opioid; Spinal Cord	1992
Cocaine self-administration differentially alters mRNA expression of striatal peptides. Brain research. Molecular brain research, 1992, Volume: 13, Issue:1-2 Topics: Animals; Autoradiography; Caudate Nucleus; Cocaine; Corpus Striatum; Deoxyadenine Nucleotides; Dynorphins; Enkephalins; Gene Expression; Male; Oligonucleotide Probes; Rats; Reference Values; RNA, Messenger; Self Administration; Substance P; Sulfur Radioisotopes	1992
Cocaine-induced changes in gene expression in rat brain. NIDA research monograph, 1990, Volume: 105 Topics: Animals; Brain; Cocaine; DNA-Binding Proteins; Early Growth Response Protein 1; Enkephalins; Gene Expression; Immediate-Early Proteins; Male; Protein Precursors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; RNA, Messenger; Signal Transduction; Synapses; Transcription Factors; Transcription, Genetic	1990
Intravenous self-administration of an enkephalin analog, EK-399, by rats. The Journal of toxicological sciences, 1991, Volume: 16, Issue:2 Topics: Analgesics; Animals; Behavior, Animal; Cocaine; Enkephalins; Infusions, Intravenous; Male; Morphine; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Administration; Substance-Related Disorders	1991
Membrane properties and adrenergic responses in locus coeruleus neurons of young rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:11 Topics: Adrenergic alpha-Agonists; Animals; Cocaine; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Neurons; Norepinephrine; Phenylephrine; Prazosin; Rats	1987
Behavioral cross-sensitization between cocaine and enkephalin in the A10 dopamine region. Behavioural brain research, 1988, Volume: 27, Issue:1 Topics: Animals; Brain; Cocaine; Dopamine; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Motor Activity; Movement; Neurons; Rats; Rats, Inbred Strains; Stereotyped Behavior	1988
The effect of (D-Ala2)-Met-enkephalin on the contraction of nictitating membrane in cats. European journal of pharmacology, 1980, May-02, Volume: 63, Issue:2-3 Topics: Animals; Cats; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Morphine; Muscle Contraction; Naloxone; Nictitating Membrane; Norepinephrine; Sympathetic Nervous System	1980
Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:12 Topics: Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P	1993
Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat. Neuroscience, 1994, Volume: 59, Issue:4 Topics: Amphetamine; Animals; Biomarkers; Brain; Caffeine; Choline O-Acetyltransferase; Cocaine; Corpus Striatum; Dopamine; Enkephalins; Gene Expression Regulation; Genes, fos; Male; Nerve Tissue Proteins; Neurokinin B; Neurons; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Somatostatin; Substance P	1994
The human neostriatum shows compartmentalization of neuropeptide gene expression in dorsal and ventral regions: an in situ hybridization histochemical analysis. Neuroscience, 1995, Volume: 64, Issue:3 Topics: Acetylcholinesterase; Adolescent; Adult; Cocaine; Enkephalins; Female; Gene Expression Regulation; Humans; In Situ Hybridization; Male; Middle Aged; Neostriatum; Neurokinin A; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, mu; RNA, Messenger; Somatostatin; Substance P; Tachykinins	1995
Cocaine binges differentially alter striatal preprodynorphin and zif/268 mRNAs. Brain research. Molecular brain research, 1995, Volume: 29, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Corpus Striatum; Disease Models, Animal; DNA-Binding Proteins; Drug Administration Schedule; Dynorphins; Early Growth Response Protein 1; Enkephalins; Immediate-Early Proteins; Male; Nerve Tissue Proteins; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors	1995
Cocaine alters glutamic acid decarboxylase differentially in the nucleus accumbens core and shell. Brain research. Molecular brain research, 1995, Volume: 29, Issue:2 Topics: Analysis of Variance; Animals; Cocaine; Drug Administration Schedule; Enkephalins; gamma-Aminobutyric Acid; Genetic Code; Glutamate Decarboxylase; Male; Neurons; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Tachykinins	1995
Short-term cocaine self administration alters striatal gene expression. Brain research bulletin, 1995, Volume: 37, Issue:5 Topics: Animals; Cocaine; Dynorphins; Enkephalins; Gene Expression; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Neostriatum; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Self Administration	1995
Molecular alterations in the neostriatum of human cocaine addicts. Synapse (New York, N.Y.), 1993, Volume: 13, Issue:4 Topics: Adolescent; Adult; Autoradiography; Cocaine; Dynorphins; Enkephalins; Female; Histocytochemistry; Humans; In Situ Hybridization; Male; Middle Aged; Neostriatum; Nucleus Accumbens; Putamen; Receptors, Dopamine; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Substance P; Substance-Related Disorders	1993
Prenatal cocaine increases striatal serotonin innervation without altering the patch/matrix organization of intrinsic cell types. Brain research. Developmental brain research, 1993, Aug-20, Volume: 74, Issue:2 Topics: Acetylcholinesterase; Aging; Animals; Calbindins; Cocaine; Corpus Striatum; Enkephalins; Female; Immunohistochemistry; Male; NADPH Dehydrogenase; Neurons, Afferent; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Serotonin; Substance P; Substantia Nigra	1993
'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Brain research. Molecular brain research, 1993, Volume: 19, Issue:4 Topics: Animals; Brain; Caudate Nucleus; Cocaine; Drug Administration Schedule; Enkephalins; Humans; Male; Organ Specificity; Protein Precursors; Putamen; Rats; Rats, Inbred F344; RNA; RNA, Messenger; Substance-Related Disorders; Time Factors	1993
Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors. Neuroreport, 1994, Aug-15, Volume: 5, Issue:13 Topics: Analgesics; Animals; Autoradiography; Brain; Brain Chemistry; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Up-Regulation	1994
Acute and chronic cocaine administration differentially alters striatal opioid and nuclear transcription factor mRNAs. Synapse (New York, N.Y.), 1994, Volume: 18, Issue:1 Topics: Animals; Cell Nucleus; Cocaine; Dynorphins; Endorphins; Enkephalins; Gene Expression Regulation; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Neostriatum; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors	1994
Chronic administration of a cocaine "binge" alters basal extracellular levels in male rats: an in vivo microdialysis study. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2 Topics: Analysis of Variance; Animals; Cocaine; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Microdialysis; Rats; Rats, Inbred F344	1995
Convulsant doses of cocaine alter immediate early gene and opioid peptide expression in rat limbic forebrain. Brain research. Molecular brain research, 1993, Volume: 20, Issue:3 Topics: Animals; Cocaine; Convulsants; DNA-Binding Proteins; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Immediate-Early Proteins; In Situ Hybridization; Kindling, Neurologic; Limbic System; Male; Nerve Tissue Proteins; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Seizures; Time Factors; Transcription Factors	1993
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1994, Volume: 14, Issue:3 Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides	1994
The effects of cocaine-induced seizures on the proenkephalin mRNA level in the mouse hippocampus: a possible involvement of the nitric oxide pathway. Neuroscience letters, 1994, Feb-28, Volume: 168, Issue:1-2 Topics: Animals; Arginine; Cocaine; Enkephalins; Gene Expression; Hippocampus; In Situ Hybridization; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Protein Precursors; RNA, Messenger; Seizures	1994
Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse (New York, N.Y.), 1993, Volume: 15, Issue:1 Topics: Adenylyl Cyclases; Analgesics; Animals; Caudate Nucleus; Cocaine; Cyclic AMP; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Nucleus Accumbens; Putamen; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values	1993
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat. European journal of pharmacology, 1993, Jan-26, Volume: 231, Issue:1 Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu	1993
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature, 1996, Feb-15, Volume: 379, Issue:6566 Topics: Amphetamine; Animals; Carrier Proteins; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Female; Gene Expression Regulation; Gene Targeting; Locomotion; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Protein Precursors; Rats	1996
Chronic intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat hypothalamus and caudate-putamen. Brain research. Molecular brain research, 1996, Volume: 40, Issue:1 Topics: Animals; Caudate Nucleus; Cerebral Ventricles; Cocaine; Enkephalins; Hypothalamus; Infusions, Parenteral; Male; Protein Precursors; Putamen; Rats; Rats, Inbred F344; RNA, Messenger; Transcription, Genetic	1996
Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology, 1996, Feb-15, Volume: 297, Issue:1-2 Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Membranes; Narcotics; Neostriatum; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu	1996
D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum. Neuroscience, 1996, Volume: 74, Issue:3 Topics: Animals; Base Sequence; Body Weight; Brain; Cocaine; Corpus Striatum; DNA-Binding Proteins; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Genes, Immediate-Early; Heterozygote; Homozygote; Immediate-Early Proteins; In Situ Hybridization; Mice; Mice, Knockout; Molecular Sequence Data; Oligonucleotide Probes; Organ Size; Proto-Oncogene Proteins c-fos; Receptors, Dopamine D1; RNA, Messenger; Substance P; Transcription Factors; Transcription, Genetic; Transcriptional Activation	1996
Dopamine antagonist and "binge' cocaine effects on rat opioid and dopamine transporter mRNAs. Neuroreport, 1996, Sep-02, Volume: 7, Issue:13 Topics: Analysis of Variance; Animals; Benzazepines; Brain; Carrier Proteins; Cocaine; DNA Primers; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Dynorphins; Enkephalins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Polymerase Chain Reaction; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; RNA, Messenger; Substance-Related Disorders; Sulpiride; Transcription, Genetic	1996
Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Feb-01, Volume: 17, Issue:3 Topics: Animals; Brain; Cocaine; Dynorphins; Enkephalins; Female; Gene Expression Regulation; Macaca mulatta; Narcotics; Pregnancy; Protein Precursors; RNA, Messenger	1997
Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1995, Volume: 5, Issue:4 Topics: Adaptation, Physiological; Animals; Autoradiography; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; In Situ Hybridization; Injections; Male; Neostriatum; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; Receptors, Dopamine D2; RNA, Messenger	1995
Prodynorphin, proenkephalin and kappa opioid receptor mRNA responses to acute "binge" cocaine. Brain research. Molecular brain research, 1997, Volume: 44, Issue:1 Topics: Animals; Cocaine; Enkephalins; Male; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; RNA, Messenger; Time Factors	1997
Differential effects of mu-, delta- and kappa-opioid receptor agonists on the discriminative stimulus properties of cocaine in rats. European journal of pharmacology, 1997, Apr-11, Volume: 324, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Narcotics; Pyrrolidines; Quinolines; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders	1997
Long-term cocaine self-administration decreases striatal preproenkephalin mRNA in rhesus monkeys. Pharmacology, biochemistry, and behavior, 1997, Volume: 57, Issue:3 Topics: Animals; Cocaine; Corpus Striatum; Enkephalins; In Situ Hybridization; Macaca mulatta; Male; Protein Precursors; RNA, Messenger; Self Administration; Time Factors	1997
Dopamine-mediated gene regulation in the striatum. Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cocaine; Corpus Striatum; Dopamine; Dynorphins; Enkephalins; Gene Expression Regulation; Neurons; Proto-Oncogene Proteins c-fos; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance P; Transcription, Genetic	1998
Alterations in behavior and opioid gene expression induced by the novel tropane analog WF-31. Brain research. Molecular brain research, 1997, Oct-15, Volume: 50, Issue:1-2 Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Fluoxetine; Gene Expression; Genome; Male; Motor Activity; Protein Precursors; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tropanes	1997
Repeated administration of cocaine, nicotine and ethanol: effects on preprodynorphin, preprotachykinin A and preproenkephalin mRNA expression in the dorsal and the ventral striatum of the rat. Brain research. Molecular brain research, 1998, Volume: 54, Issue:1 Topics: Animals; Body Weight; Cocaine; Corpus Striatum; Drug Administration Schedule; Dynorphins; Enkephalins; Ethanol; In Situ Hybridization; Injections, Subcutaneous; Male; Nicotine; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tachykinins	1998
Interactions of cocaine with morphine, U-50,488H and [D-Pen2, D-Pen5]enkaphalin. Peptides, 1998, Volume: 19, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Male; Mice; Morphine; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1998
Specific reductions of striatal prodynorphin and D1 dopamine receptor messenger RNAs during cocaine abstinence. Brain research. Molecular brain research, 1998, Volume: 56, Issue:1-2 Topics: Animals; Cocaine; Corpus Striatum; Enkephalins; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance Withdrawal Syndrome	1998
Changes in the midbrain-rostral forebrain dopamine circuitry in the cocaine-exposed primate fetal brain. Annals of the New York Academy of Sciences, 1998, Jun-21, Volume: 846 Topics: Amniotic Fluid; Animals; Body Weight; Brain; Cocaine; Dopamine; Dynorphins; Embryonic and Fetal Development; Enkephalins; Female; Gene Expression Regulation, Developmental; Macaca mulatta; Mesencephalon; Metabolic Clearance Rate; Neurons; Pregnancy; Prosencephalon; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Transcription, Genetic	1998
Transient upregulation of mu opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration. Canadian journal of physiology and pharmacology, 1998, Volume: 76, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics, Opioid; Animals; Benzopyrans; Bromocriptine; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation; Male; Nucleus Accumbens; Oxazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger; Time Factors; Up-Regulation	1998
Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. Neuroscience, 1998, Volume: 85, Issue:4 Topics: Amphetamine; Animals; Autoradiography; Brain Chemistry; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Endorphins; Enkephalins; In Situ Hybridization; Male; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; RNA, Messenger	1998
Perinatal cocaine decreases the expression of prodynorphin mRNA in nucleus accumbens shell in the adult rat. Brain research. Molecular brain research, 1998, Nov-12, Volume: 62, Issue:1 Topics: Animals; Animals, Newborn; Cocaine; Enkephalins; Female; Gene Expression Regulation; In Situ Hybridization; Injections, Subcutaneous; Male; Nucleus Accumbens; Prosencephalon; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger	1998
Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections. Drug and alcohol dependence, 1998, Oct-01, Volume: 52, Issue:2 Topics: Analgesics, Opioid; Animals; Brain; Caudate Nucleus; Cocaine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Heroin Dependence; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Opioid, mu; Self Administration	1998
Modulation of cocaine-induced antinociception by opioid-receptor agonists. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa	1999
A heroin-, but not a cocaine-expecting, self-administration state preferentially alters endogenous brain peptides. European journal of pharmacology, 1999, Jan-22, Volume: 365, Issue:2-3 Topics: Animals; Behavior, Animal; Brain; Cocaine; Dynorphins; Enkephalins; Heroin; Injections, Intravenous; Male; Neuropeptides; Radioimmunoassay; Rats; Rats, Wistar; Self Administration; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors	1999
The mu opioid agonist DAMGO alters the intravenous self-administration of cocaine in rats: mechanisms in the ventral tegmental area. Psychopharmacology, 1999, Volume: 141, Issue:4 Topics: Analgesics, Opioid; Animals; Cocaine; Dopamine Uptake Inhibitors; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intravenous; Male; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu; Self Administration; Ventral Tegmental Area	1999
Blockade of neurotensin receptors suppresses the dopamine D1/D2 synergism on immediate early gene expression in the rat brain. The European journal of neuroscience, 1999, Volume: 11, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Brain Chemistry; Cocaine; DNA-Binding Proteins; Dopamine Agonists; Dopamine Uptake Inhibitors; Early Growth Response Protein 1; Enkephalins; Gene Expression; Genes, Immediate-Early; Immediate-Early Proteins; In Situ Hybridization; Male; Neostriatum; Neurons; Proto-Oncogene Proteins c-fos; Pyrazoles; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Neurotensin; RNA, Messenger; Transcription Factors	1999
Interrupted expression of NAC-1 augments the behavioral responses to cocaine. Synapse (New York, N.Y.), 1999, Volume: 33, Issue:2 Topics: Animals; Behavior, Animal; Cocaine; Dopamine; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Microdialysis; Microinjections; Motor Activity; Nerve Tissue Proteins; Nucleus Accumbens; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Repressor Proteins; RNA, Messenger	1999
Manipulations of mu-opioid and nicotinic cholinergic receptors in the pontine tegmental region alter cocaine self-administration in rats. Psychopharmacology, 1999, Volume: 145, Issue:4 Topics: Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Microinjections; Pons; Rats; Rats, Long-Evans; Receptors, Nicotinic; Receptors, Opioid, mu; Self Administration; Somatostatin; Ventral Tegmental Area	1999
Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine. Neuroreport, 1999, Nov-08, Volume: 10, Issue:16 Topics: Amygdala; Animals; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Estradiol; Female; Limbic System; Male; Nerve Tissue Proteins; Nucleus Accumbens; Ovariectomy; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sex Characteristics	1999
Correlates of deoxycorticosterone-induced salt appetite behavior and basal ganglia neurochemistry. Annals of the New York Academy of Sciences, 1999, Volume: 897 Topics: Animals; Appetite; Basal Ganglia; Carrier Proteins; Cocaine; Desoxycorticosterone; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Gene Expression Regulation; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium, Dietary; Transcription, Genetic; Tyrosine 3-Monooxygenase	1999
Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen. The European journal of neuroscience, 2000, Volume: 12, Issue:8 Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Gene Expression; In Situ Hybridization; Male; Morphine; Naloxone; Narcotic Antagonists; Neostriatum; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Running; Species Specificity; Substance P	2000
Cocaine and methamphetamine differentially affect opioid peptide mRNA expression in the striatum. Journal of neurochemistry, 2000, Volume: 75, Issue:5 Topics: Animals; Autoradiography; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; In Situ Hybridization; Male; Methamphetamine; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger	2000
Cocaine self-administration in rats differentially alters mRNA levels of the monoamine transporters and striatal neuropeptides. Brain research. Molecular brain research, 2000, Nov-10, Volume: 83, Issue:1-2 Topics: Animals; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Injections, Intravenous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Rats; Rats, Inbred Strains; RNA, Messenger; Self Administration; Serotonin Plasma Membrane Transport Proteins; Substance P; Substance Withdrawal Syndrome; Symporters	2000
Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. European journal of pharmacology, 2001, Feb-16, Volume: 413, Issue:2-3 Topics: Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Male; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger	2001
Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved. Naunyn-Schmiedeberg's archives of pharmacology, 2001, Volume: 363, Issue:3 Topics: Animals; Behavior, Animal; Cocaine; Dopamine; Dynorphins; Enkephalins; In Situ Hybridization; Locomotion; Male; Microdialysis; Neurons; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Tyrosine Transaminase	2001
Extinction of cocaine self-administration produces a differential time-related regulation of proenkephalin gene expression in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:2 Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Extinction, Psychological; Gene Expression; Male; Prosencephalon; Protein Precursors; Rats; Rats, Inbred Lew; RNA, Messenger; Self Administration; Time Factors	2001
Hypothalamic CRH mRNA levels are differentially modulated by repeated 'binge' cocaine with or without D(1) dopamine receptor blockade. Brain research. Molecular brain research, 2001, Oct-19, Volume: 94, Issue:1-2 Topics: Amygdala; Animals; Benzazepines; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamus; Male; Olfactory Bulb; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Dopamine D1; RNA, Messenger; Sulpiride	2001
cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Dec-15, Volume: 21, Issue:24 Topics: Animals; Antiparkinson Agents; Cocaine; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Denervation; DNA; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Enkephalins; Female; Gene Expression; Levodopa; Oligonucleotides, Antisense; Oxidopamine; Parkinson Disease, Secondary; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factor AP-1	2001
Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice. Synapse (New York, N.Y.), 2002, Sep-15, Volume: 45, Issue:4 Topics: Animals; Cocaine; Corpus Striatum; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamo-Hypophyseal System; Male; Medulla Oblongata; Mice; Mice, Knockout; Pituitary-Adrenal System; Pons; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, mu; RNA, Messenger	2002
In situ hybridization with isotopic riboprobes for detection of striatal neuropeptide mRNA expression after dopamine stimulant administration. Methods in molecular medicine, 2003, Volume: 79 Topics: Animals; Antisense Elements (Genetics); Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Humans; In Situ Hybridization; Protein Precursors; Rats; RNA Probes; RNA, Messenger	2003
"Binge" cocaine differentially alters preproenkephalin mRNA levels in guinea pig brain. Brain research bulletin, 2003, Jan-30, Volume: 59, Issue:5 Topics: Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Enkephalins; Guinea Pigs; Male; Protein Precursors; RNA, Messenger; Species Specificity	2003
Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawal. Brain research, 2003, Feb-28, Volume: 964, Issue:2 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Amygdala; Animals; Blotting, Northern; Cocaine; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Hypothalamo-Hypophyseal System; Male; Pituitary Gland; Pituitary-Adrenal System; Pro-Opiomelanocortin; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred F344; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors	2003
Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment. The European journal of neuroscience, 2003, Volume: 17, Issue:3 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Cocaine; Denervation; Dopamine; Dopamine Uptake Inhibitors; Enkephalins; Enzyme Inhibitors; Female; Hydroxydopamines; Immunohistochemistry; In Situ Hybridization; Levodopa; Neostriatum; Neural Pathways; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sympathectomy, Chemical	2003
Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience, 2003, Volume: 117, Issue:1 Topics: Animals; Cocaine; Enkephalins; Gene Expression Regulation; Male; Neostriatum; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptor, trkC	2003
Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine. Brain research. Molecular brain research, 2003, May-26, Volume: 114, Issue:1 Topics: Amygdala; Animals; Brain Stem; Chronic Disease; Cocaine; Cocaine-Related Disorders; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Substance Withdrawal Syndrome	2003
Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration. The European journal of neuroscience, 2003, Volume: 17, Issue:10 Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Macaca mulatta; Male; Protein Precursors; RNA, Messenger; Self Administration; Up-Regulation	2003
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jul-02, Volume: 23, Issue:13 Topics: Analgesia; Animals; Behavior, Animal; Cocaine; Drug Synergism; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Threshold; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Reward; Spatial Behavior; Stress, Physiological; Swimming	2003
Repeated methylphenidate treatment in adolescent rats alters gene regulation in the striatum. The European journal of neuroscience, 2003, Volume: 18, Issue:6 Topics: Anesthetics, Local; Animals; Autoradiography; Cell Count; Central Nervous System Stimulants; Cocaine; Corpus Striatum; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Administration Schedule; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Gene Silencing; Genes, fos; Immediate-Early Proteins; In Situ Hybridization; Male; Methylphenidate; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance P; Transcription Factors	2003
Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain. Journal of molecular neuroscience : MN, 2004, Volume: 22, Issue:3 Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression Regulation; Male; p-Chloroamphetamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Time; Up-Regulation	2004
Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology, 2004, Volume: 175, Issue:1 Topics: Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Extinction, Psychological; Male; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Recurrence; RNA, Messenger; Self Administration; Time Factors	2004
Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS. Brain research. Molecular brain research, 2004, Aug-23, Volume: 127, Issue:1-2 Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Northern; Central Nervous System; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression; Male; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors	2004
Effect of acute and chronic psychostimulant drugs on redox status, AP-1 activation and pro-enkephalin mRNA in the human astrocyte-like U373 MG cells. Neuropharmacology, 2005, Volume: 48, Issue:5 Topics: Amino Acid Transport System X-AG; Amphetamine; Analysis of Variance; Astrocytes; Blotting, Western; Cell Line; Central Nervous System Agents; Cocaine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrophoretic Mobility Shift Assay; Enkephalins; Excitatory Amino Acid Transporter 2; Fluoresceins; Fos-Related Antigen-2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Oxidation-Reduction; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factor AP-1; Transcription Factors	2005
Blunted response to cocaine in the Flinders hypercholinergic animal model of depression. Neuroscience, 2005, Volume: 132, Issue:4 Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Depression; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Enkephalins; In Situ Hybridization; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Protein Precursors; Rats; RNA, Messenger	2005
Blockade of melanocortin transmission inhibits cocaine reward. The European journal of neuroscience, 2005, Volume: 21, Issue:8 Topics: Agouti Signaling Protein; alpha-MSH; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enkephalins; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Melanocyte-Stimulating Hormones; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nucleus Accumbens; Protein Precursors; Rats; Rats, Mutant Strains; Receptor, Melanocortin, Type 4; Reward; RNA, Messenger; Self Administration; Time Factors	2005
Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex. Brain research. Molecular brain research, 2005, Jun-13, Volume: 137, Issue:1-2 Topics: Animals; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Down-Regulation; Drug Administration Schedule; Enkephalins; Frontal Lobe; Male; Narcotic Antagonists; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors	2005
Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:6 Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Enkephalins; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Social Behavior; Stress, Psychological	2006
Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Drug Interactions; Enkephalins; Enzyme Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Time Factors	2006
Gene expression regulation following behavioral sensitization to cocaine in transgenic mice lacking the glucocorticoid receptor in the brain. Neuroscience, 2006, Volume: 137, Issue:3 Topics: Animals; Behavior, Animal; Brain Chemistry; Cocaine; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Gene Expression Regulation; GluK2 Kainate Receptor; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Transgenic; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Glucocorticoid; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance P; Synaptic Transmission	2006
Motor-skill learning-associated gene regulation in the striatum: effects of cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:12 Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Dopamine; Dynorphins; Enkephalins; Gene Expression Regulation; Learning; Male; Motor Activity; Motor Skills; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Up-Regulation	2006
Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:12 Topics: Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Corpus Striatum; Disease Models, Animal; Dopamine Uptake Inhibitors; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Immediate-Early; Limbic System; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proto-Oncogene Proteins c-fos; Ventral Tegmental Area	2006
Contingency does not contribute to the effects of cocaine self-administration on prodynorphin and proenkephalin gene expression in the rat forebrain. Brain research, 2006, Jan-19, Volume: 1069, Issue:1 Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Diagnostic Imaging; Enkephalins; Gene Expression; In Situ Hybridization; Male; Prosencephalon; Protein Precursors; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; RNA, Messenger; Self Administration	2006
Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. The European journal of neuroscience, 2006, Volume: 24, Issue:3 Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Enkephalins; GABA Agonists; Gene Expression; Male; Motor Activity; Neostriatum; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Time; Time Factors; Up-Regulation	2006
Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS. Neuroscience, 2007, Jan-05, Volume: 144, Issue:1 Topics: Animals; Benzeneacetamides; Blotting, Northern; Central Nervous System; Cocaine; Dynorphins; Enkephalins; Fluoxetine; Hippocampus; Hypothalamus; Male; Neostriatum; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA Probes; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin	2007
Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens. Neuropeptides, 2006, Volume: 40, Issue:6 Topics: Animals; Cocaine; Enkephalins; Male; Microscopy, Fluorescence; Models, Biological; Nerve Tissue Proteins; Neurons; Neuropeptides; Nucleus Accumbens; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Substance-Related Disorders	2006
Gender differences in prodynorphin but not proenkephalin mRNA expression in the striatum of adolescent rats exposed to prenatal cocaine. Neuroscience letters, 2007, Jun-29, Volume: 421, Issue:3 Topics: Animals; Animals, Newborn; Cocaine; Corpus Striatum; Enkephalins; Female; Gene Expression Regulation, Developmental; Male; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; RNA, Messenger; Sex Characteristics	2007
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides. Neuropharmacology, 2010, Volume: 58, Issue:1 Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors	2010
Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain. Biochemical and biophysical research communications, 2012, Mar-23, Volume: 419, Issue:4 Topics: Animals; Cocaine; Corpus Striatum; Enkephalins; Gene Expression; Male; Metalloendopeptidases; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger	2012
Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice. Neuropharmacology, 2012, Volume: 63, Issue:2 Topics: Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Drug Administration Schedule; Enkephalins; Male; Mice; Mice, Inbred C57BL; Protein Precursors; RNA, Messenger; Substance Withdrawal Syndrome	2012
A role for Sv2c in basal ganglia functions. Brain research, 2013, Apr-24, Volume: 1507 Topics: Animals; Basal Ganglia; Cocaine; Corpus Striatum; Dopaminergic Neurons; Enkephalins; Gene Knockdown Techniques; Locomotion; Male; Maze Learning; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Nerve Tissue Proteins; Oxidopamine; Tyrosine 3-Monooxygenase	2013
BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior. Nature communications, 2013, Volume: 4 Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cocaine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enkephalins; Enzyme Activation; Excitatory Postsynaptic Potentials; Gait; Gene Deletion; Globus Pallidus; Green Fluorescent Proteins; Integrases; Locomotion; Mice; Mice, Knockout; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Protein Kinase C; Receptor, trkB; Receptors, Dopamine D2; Signal Transduction; Synapses	2013
Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry, 2014, Mar-03, Volume: 49 Topics: Animals; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; Epigenesis, Genetic; Gene Expression Regulation; Histones; Male; Nociceptin; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Receptors, Opioid; Receptors, Opioid, kappa	2014
Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PloS one, 2014, Volume: 9, Issue:5 Topics: Analysis of Variance; Animals; Anxiety; Cocaine; Dependovirus; Depression; Enkephalins; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Vectors; In Situ Hybridization; Locomotion; Maze Learning; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; RNA, Small Interfering	2014
Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:13 Topics: Analysis of Variance; Anesthetics, Local; Animals; Cocaine; Conditioning, Operant; Cues; Drug-Seeking Behavior; Enkephalins; Gene Expression Regulation; Mice; Mice, Knockout; Protein Precursors; Proto-Oncogene Proteins c-fos; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement Schedule; Reinforcement, Psychology; Self Administration	2014
Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization. Addiction biology, 2016, Volume: 21, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Enkephalins; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Nucleus Accumbens; Phosphorylation	2016
Cocaine Self-administration Regulates Transcription of Opioid Peptide Precursors and Opioid Receptors in Rat Caudate Putamen and Prefrontal Cortex. Neuroscience, 2020, 09-01, Volume: 443 Topics: Animals; Cocaine; Enkephalins; Opioid Peptides; Prefrontal Cortex; Putamen; Rats; Receptors, Opioid; Receptors, Opioid, mu	2020
Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience, 2021, Volume: 53, Issue:5 Topics: Animals; Cocaine; Enkephalins; Glutamic Acid; Mice; Microdialysis; Nucleus Accumbens	2021
Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward. Cell reports, 2022, 09-27, Volume: 40, Issue:13 Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Mice; Narcotic Antagonists; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; RNA, Messenger	2022
Endogenous opioid system modulates conditioned cocaine reward in a sex-dependent manner. Addiction biology, 2023, Volume: 28, Issue:10 Topics: Analgesics, Opioid; Animals; Cocaine; Enkephalins; Female; Male; Mice; Naloxone; Narcotic Antagonists; Opioid Peptides; Reward	2023