enkephalin, leucine and biphalin

enkephalin, leucine has been researched along with biphalin in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.59)	18.7374
1990's	15 (23.81)	18.2507
2000's	15 (23.81)	29.6817
2010's	26 (41.27)	24.3611
2020's	6 (9.52)	2.80

Authors

Authors	Studies
Carr, DB; Cepeda, MS; Lipkowski, AW; Osgood, PF; Silbert, BS; Szyfelbein, SK	2
Carr, DB; Lipkowski, AW; Osgood, PF; Silbert, BS; Szyfelbein, SK	1
Kamei, J; Kasuya, Y	1
Carr, DB; Dorociak, A; Gumulka, SW; Lipkowski, AW; Maszczynska, I; Misterek, K; Szyfelbein, SK	1
Appleyard, SM; Bilsky, EJ; Davis, TP; Horan, PJ; Malatynska, E; Mattia, A; Misicka, A; Slaninova, J; Weber, S; Yamamura, HI	1
Abbruscato, TJ; Davis, TP; Hruby, VJ; Lipkowski, AW; Misicka, A; Williams, SA	1
Crain, SM; Shen, KF	1
Davis, P; Horvath, R; Hruby, VJ; Lipkowski, AW; Misicka, A; Porreca, F; Yamamura, HI	1
Abbruscato, TJ; Davis, TP; Hruby, VJ; Thomas, SA	1
Hruby, VJ; Lipkowski, AW; Misicka, A; O'Brien, DF; Ramaswami, V; Romanowski, M; Zhu, X	1
Appleyard, SM; Davis, TP; Hruby, VJ; Knapp, RJ; Lipkowski, AW; Misicka, A; Slaninova, J; Weber, SJ; Yamamura, HI	1
Abbruscato, TJ; Davis, TP; Egleton, RD; Thomas, SA	1
Lipkowski, AW; Specter, S; Tang, JL	1
Davis, P; Davis, TP; De Leon, IA; Gillespie, TJ; Haq, W; Hruby, VJ; Hughes, R; Li, G; Lipkowski, AW; Lou, BS; Misicka, A; O'Brien, DF; Porreca, F; Romanowski, M; Xiang, L; Yamamura, HI; Zhu, X	1
Davis, P; Hruby, VJ; Janders, J; Lachwa, M; Lipkowski, AW; Misicka, A; Porreca, F; Stropova, D; Yamamura, HI	1
Hettiarachchi, K; Obi, CR; Olson, L; Ridge, S; Singh, D; Thomas, DW	1
Lipkowski, AW; Narita, M; Suzuki, T; Yamazaki, M	1
Hruby, VJ; Kim, K; O'Brien, DF; Romanowski, M; Zhu, X	1
Brodzik-Bienkowska, A; Hruby, VJ; Kosson, D; Kosson, P; Lachwa-From, M; Lipkowski, AW; Misicka, A	1
Deschamps, JR; Flippen-Anderson, JL; George, C; Hruby, VJ; Lipkowski, AW; Misicka, A	1
Haq, W; Mehrotra, S; Prajapati, RK; Singh, VK	1
Davis, TP; Egleton, RD; Huber, JD; Witt, KA	1
Bonney, IM; Carr, DB; Hasirci, V; Lipkowski, AW; Sendil, D; Wise, DL	1
Bentley, MD; Campos, CR; Davis, TP; Egleton, RD; Guo, L; Huber, JD; Roberts, MJ; Witt, K	1
Fichna, J; Janecka, A; Janecki, T	1
Carr, DB; Hasirci, V; Lipkowski, AW; Maszczynska Bonney, I; Sendil Keskin, D	1
Davis, P; Hruby, VJ; Lai, J; Ma, SW; Mollica, A; Porreca, F	2
Bonney, I; Carr, DB; Klinowiecka, A; Kosson, D; Kosson, P; Lipkowski, AW; Mayzner-Zawadzka, E	1
Lipkowski, AW; Szereda-Przestaszewska, M; Wojciechowski, P	2
Lazarczyk, M; Lipkowski, AW; Matyja, E	1
Davis, P; Feliciani, F; Hruby, VJ; Lai, J; Lucente, G; Ma, SW; Mollica, A; Pinnen, F; Porreca, F; Stefanucci, A	1
Chen, JL; Chen, YW; Chiang, TY; Hsieh, JY; Hwang, CC; Lin, HC	1
Abbruscato, TJ; Karamyan, VT; Shah, K; Wang, H; Yang, L	2
Beresewicz, M; Kawalec, M; Kowalczyk, JE; Lipkowski, AW; Zablocka, B	1
Cacciatore, I; Costante, R; Feliciani, F; Lucente, G; Mollica, A; Pinnen, F; Stefanucci, A	1
Brunetti, L; Chiavaroli, A; Di Nisio, C; Leone, S; Mollica, A; Orlando, G; Vacca, M	1
Costante, R; Fidanza, S; Lucente, G; Mollica, A; Pieretti, S; Pinnen, F; Stefanucci, A	1
Costante, R; Davis, P; Hruby, VJ; Lai, J; Locatelli, M; Mollica, A; Pieretti, S; Pinnen, F; Porreca, F; Rankin, D; Stefanucci, A	1
An, G; Li, G; Lin, S; Pan, Y; Sun, H; Wu, J; Xie, J; Zhou, W	1
Frączak, O; Lasota, A; Leśniak, A; Lipkowski, AW; Olma, A	1
Costante, R; Mollica, A; Pinnen, F; Stefanucci, A	1
Fichna, J; Jarmuż, A; Jonakowski, M; Lipkowski, AW; Pilarczyk, A; Sałaga, M; Sobczak, M	1
Dyniewicz, J; Garbuz, O; Gulea, A; Lipkowski, AW; Zablocka, B	1
Frączak, O; Kosson, P; Lasota, A; Leśniak, A; Lipkowski, AW; Muchowska, A; Olma, A	1
Abbruscato, TJ; Islam, MR; Karamyan, VT; Yang, L	1
Lesniak, A; Lipkowski, AW; Misicka, A; Pick, CG; Sacharczuk, M	1
Fichna, J; Jarmuż, A; Lipkowski, AW; Sałaga, M; Zielińska, M	1
Bądzyńska, B; Lipkowski, AW; Sadowski, J	1
Benhye, S; Bochynska-Czyz, M; Bujalska-Zadrozny, M; Lesniak, A; Lipkowski, AW; Misicka, A; Sacharczuk, M	1
Cowell, SM; Lee, YS	1
Makuch, W; Mika, J; Piotrowska, A; Popiolek-Barczyk, K	1
Carradori, S; Hruby, VJ; Lei, W; Luisi, G; Macedonio, G; Mollica, A; Stefanucci, A; Streicher, JM	1
Hruby, V; Lee, YS; Macedonio, G; Mollica, A; Porreca, F; Remesic, M	1
Czuwara, J; Kosson, P; Lipiński, PFJ; Matalińska, J; Muchowska, A; Redkiewicz, P; Różycki, K	1
Misicka, A; Tymecka, D	1
Chen, S; Li, Y; Min, JW; Yang, XF; Zhang, JJ	1
Gedar Totuk, OM; Kabadayi, K; Mollica, A; Sahin, A; Yildiz, E	1
Abbruscato, TJ; Albekairi, TH; Nozohouri, S; Vaidya, B; Zhang, Y	1
Dyniewicz, J; Misicka, A; Redkiewicz, P	1

Reviews

5 review(s) available for enkephalin, leucine and biphalin

Article	Year
Opioid receptors and their ligands. Current topics in medicinal chemistry, 2004, Volume: 4, Issue:1 Topics: Amino Acid Sequence; Animals; Brain; Dynorphins; Enkephalins; Humans; Ligands; Molecular Sequence Data; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Protein Binding; Receptors, Opioid; Recombinant Fusion Proteins; Structure-Activity Relationship	2004
Advances in analgesic drug design and delivery: a current survey. Advances in experimental medicine and biology, 2004, Volume: 553 Topics: Analgesics; Drug Delivery Systems; Drug Design; Enkephalins; Humans; Microspheres; Narcotics; Pain; Polymers; Substance P	2004
Structure-activity relationships of biphalin analogs and their biological evaluation on opioid receptors. Mini reviews in medicinal chemistry, 2013, Volume: 13, Issue:1 Topics: Animals; Enkephalins; Humans; Molecular Conformation; Receptors, Opioid; Structure-Activity Relationship	2013
Biphalin: The Foundation of Bivalent Ligands. Current medicinal chemistry, 2016, Volume: 23, Issue:29 Topics: Dimerization; Enkephalins; Humans; Ligands; Pain; Protein Binding; Receptors, Opioid; Structure-Activity Relationship	2016
Biphalin-A Potent Opioid Agonist-As a Panacea for Opioid System-Dependent Pathophysiological Diseases? International journal of molecular sciences, 2021, Oct-21, Volume: 22, Issue:21 Topics: Analgesics; Analgesics, Opioid; Enkephalins; Morphine; Opioid-Related Disorders; Pain; Receptors, Opioid	2021

Other Studies

58 other study(ies) available for enkephalin, leucine and biphalin

Article	Year
Enhanced potency of receptor-selective opioids after acute burn injury. Anesthesia and analgesia, 1991, Volume: 73, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; beta-Endorphin; Burns; Corticosterone; Dose-Response Relationship, Drug; Enkephalins; Injections, Intravenous; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains	1991
Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration. Agents and actions, 1991, Volume: 33, Issue:3-4 Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalins; Injections, Intravenous; Injections, Spinal; Injections, Subcutaneous; Male; Molecular Sequence Data; Morphine; Rats; Rats, Inbred Strains; Reaction Time; Structure-Activity Relationship	1991
Peptides as potential antinociceptive drugs. Progress in clinical and biological research, 1990, Volume: 328 Topics: Analgesics; Animals; Butorphanol; Enkephalins; Male; Morphine; Peptides; Rats; Rats, Inbred Strains	1990
Effects of double-enkephalin (biphalin), an enkephalin analogue, on respiration and the cough reflex in rats. Journal of pharmacobio-dynamics, 1988, Volume: 11, Issue:9 Topics: Analgesics; Animals; Cough; Electric Stimulation; Enkephalins; Male; Morphine; Rats; Rats, Inbred Strains; Reflex; Respiration	1988
Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin. Life sciences, 1994, Volume: 54, Issue:14 Topics: Analgesics; Animals; Drug Synergism; Enkephalins; Injections, Spinal; Male; Naltrexone; Pain; Pain Measurement; Rats; Rats, Wistar; Substance P	1994
Antinociceptive profile of biphalin, a dimeric enkephalin analog. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3 Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Digestive System; Drug Stability; Enkephalins; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphine; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders	1993
Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:3 Topics: Analgesics; Animals; Blood-Brain Barrier; Cattle; Central Nervous System; Chromatography, High Pressure Liquid; Enkephalins; Kinetics; Opioid Peptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Sucrose	1996
Biphalin, an enkephalin analog with unexpectedly high antinociceptive potency and low dependence liability in vivo, selectively antagonizes excitatory opioid receptor functions of sensory neurons in culture. Brain research, 1995, Dec-01, Volume: 701, Issue:1-2 Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Cells, Cultured; Culture Techniques; Drug Tolerance; Electrophysiology; Enkephalins; Ganglia, Spinal; Mice; Molecular Sequence Data; Morphine; Naloxone; Narcotic Antagonists; Neurons, Afferent	1995
Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4. Life sciences, 1997, Volume: 60, Issue:15 Topics: Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Structure-Activity Relationship; Vas Deferens	1997
Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry. Journal of neurochemistry, 1997, Volume: 69, Issue:3 Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalins; Iodine Radioisotopes; Kinetics; Models, Chemical; Naloxone; Naltrexone; Narcotic Antagonists; Organ Specificity; Peptides; Radioisotope Dilution Technique; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tissue Distribution	1997
Interaction of a highly potent dimeric enkephalin analog, biphalin, with model membranes. Biochimica et biophysica acta, 1997, Oct-23, Volume: 1329, Issue:2 Topics: 1,2-Dipalmitoylphosphatidylcholine; Amino Acid Sequence; Analgesics; Blood-Brain Barrier; Calorimetry, Differential Scanning; Dimerization; Enkephalin, Leucine; Enkephalins; Hydrogen-Ion Concentration; Kinetics; Liposomes; Models, Biological; Permeability; Phosphatidylcholines; Phosphatidylethanolamines; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet	1997
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes. Life sciences, 1998, Volume: 62, Issue:14 Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalins; Iodine Radioisotopes; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid	1998
Transport of opioid peptides into the central nervous system. Journal of pharmaceutical sciences, 1998, Volume: 87, Issue:11 Topics: Animals; Blood-Brain Barrier; Cattle; Cells, Cultured; Central Nervous System; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; In Vitro Techniques; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Somatostatin	1998
Inhibitory effect of biphalin and AZT on murine Friend leukemia virus infection in vitro. International journal of immunopharmacology, 1998, Volume: 20, Issue:9 Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Enkephalins; Friend murine leukemia virus; Humans; RNA-Directed DNA Polymerase; Virus Replication; Zidovudine	1998
Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide. Bioorganic & medicinal chemistry letters, 1998, Mar-03, Volume: 8, Issue:5 Topics: Analgesics; Animals; Enkephalins; Guinea Pigs; In Vitro Techniques; Lipid Bilayers; Receptors, Opioid, mu; Structure-Activity Relationship; Thermodynamics	1998
Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin. Bioorganic & medicinal chemistry letters, 1999, Sep-20, Volume: 9, Issue:18 Topics: Amino Acid Sequence; Analgesics; Enkephalins; Receptors, Opioid, mu	1999
Characterization and analysis of biphalin: an opioid peptide with a palindromic sequence. The journal of peptide research : official journal of the American Peptide Society, 2001, Volume: 57, Issue:2 Topics: Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Enkephalins; Nuclear Magnetic Resonance, Biomolecular; Spectrometry, Mass, Electrospray Ionization	2001
The opioid peptide analogue biphalin induces less physical dependence than morphine. Life sciences, 2001, Jul-20, Volume: 69, Issue:9 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Enkephalins; Infusions, Intravenous; Male; Morphine; Morphine Dependence; Naloxone; Pentazocine; Rats; Rats, Sprague-Dawley; Substance-Related Disorders; Weight Loss	2001
Interaction of enkephalin peptides with anionic model membranes. Biochimica et biophysica acta, 2002, Jan-02, Volume: 1558, Issue:1 Topics: Analgesics; Anions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Lipid Bilayers; Membranes, Artificial; Molecular Structure; Peptides, Cyclic; Permeability; Phospholipids; Protein Conformation; Static Electricity; Surface Properties	2002
Biological properties of a new fluorescent biphalin fragment analogue. Life sciences, 2002, Jan-11, Volume: 70, Issue:8 Topics: Analgesia; Analgesics; Animals; Dansyl Compounds; Enkephalins; Fluorescent Dyes; Male; Pain; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu	2002
Crystal structure of biphalin sulfate: a multireceptor opioid peptide. The journal of peptide research : official journal of the American Peptide Society, 2002, Volume: 59, Issue:3 Topics: Binding Sites; Crystallography, X-Ray; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen Bonding; Naltrexone; Narcotics; Oligopeptides; Pliability; Protein Conformation; Protein Folding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Substrate Specificity; Tetrahydroisoquinolines	2002
Immunomodulation by biphalin, dimeric synthetic opioid peptide, and its analog. Immunopharmacology and immunotoxicology, 2002, Volume: 24, Issue:1 Topics: Adjuvants, Immunologic; Animals; Cell Line; Chemotaxis, Leukocyte; Cytotoxicity, Immunologic; Enkephalins; Humans; Interleukin-2; Killer Cells, Natural; Leukocytes, Mononuclear; Macrophages; Mice; Nitric Oxide; Tumor Necrosis Factor-alpha	2002
Pluronic p85 block copolymer enhances opioid peptide analgesia. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2 Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Capillaries; Drug Synergism; Endothelium, Vascular; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Poloxalene; Reaction Time; Solvents	2002
Antinociceptive effects of hydromorphone, bupivacaine and biphalin released from PLGA polymer after intrathecal implantation in rats. Biomaterials, 2003, Volume: 24, Issue:11 Topics: Analgesics; Animals; Bupivacaine; Drug Delivery Systems; Drug Implants; Enkephalins; Hydromorphone; Injections, Spinal; Lactic Acid; Male; Pain; Pain Measurement; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley	2003
Conjugation of low molecular weight poly(ethylene glycol) to biphalin enhances antinociceptive profile. Journal of pharmaceutical sciences, 2003, Volume: 92, Issue:7 Topics: Analgesics; Animals; Enkephalins; Male; Mice; Mice, Inbred ICR; Pain Measurement; Polyethylene Glycols	2003
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers. Bioorganic & medicinal chemistry letters, 2005, May-16, Volume: 15, Issue:10 Topics: Enkephalins; Hydrazines; Magnetic Resonance Spectroscopy; Molecular Structure; Radioligand Assay	2005
Synthesis and biological activity of the first cyclic biphalin analogues. Bioorganic & medicinal chemistry letters, 2006, Jan-15, Volume: 16, Issue:2 Topics: Binding Sites; Cyclization; Enkephalins; Ligands; Molecular Structure; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship	2006
Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin. European journal of pain (London, England), 2008, Volume: 12, Issue:5 Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Drug Synergism; Drug Therapy, Combination; Drug Tolerance; Enkephalins; Excitatory Amino Acid Antagonists; Hot Temperature; Injections, Spinal; Ketamine; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Tail	2008
Respiratory and cardiovascular effects of biphalin in anaesthetized rats. European journal of pharmacology, 2009, Jan-05, Volume: 602, Issue:1 Topics: Analgesics; Animals; Blood Pressure; Bradycardia; Cardiovascular System; Chloralose; Enkephalins; Heart Rate; Male; Naloxone; Rats; Rats, Wistar; Receptors, Opioid; Respiratory System; Time Factors; Urethane; Vagotomy	2009
A comparative study of morphine stimulation and biphalin inhibition of human glioblastoma T98G cell proliferation in vitro. Peptides, 2010, Volume: 31, Issue:8 Topics: Analgesics, Opioid; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Design; Enkephalins; Glioblastoma; Humans; Immunohistochemistry; Ki-67 Antigen; Kinetics; Morphine; Neoplastic Stem Cells; Opioid-Related Disorders; Receptors, Opioid; Tumor Stem Cell Assay	2010
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers. Amino acids, 2011, Volume: 40, Issue:5 Topics: Enkephalins; Hydrazines; Molecular Structure; Phenylalanine; Stereoisomerism	2011
A molecular dynamics study on opioid activities of biphalin molecule. Journal of molecular modeling, 2011, Volume: 17, Issue:10 Topics: Analgesics, Opioid; Enkephalins; Molecular Dynamics Simulation	2011
Opioid receptor agonists reduce brain edema in stroke. Brain research, 2011, Apr-06, Volume: 1383 Topics: Animals; Brain Edema; Enkephalins; Hippocampus; Male; Mice; Neurons; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Recovery of Function; Stroke	2011
Neuroprotective potential of biphalin, multireceptor opioid peptide, against excitotoxic injury in hippocampal organotypic culture. Neurochemical research, 2011, Volume: 36, Issue:11 Topics: Animals; Enkephalins; Excitatory Amino Acid Agents; Hippocampus; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Opioid, delta	2011
Characterization of neuroprotective effects of biphalin, an opioid receptor agonist, in a model of focal brain ischemia. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:2 Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cell Size; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Enkephalins; Hippocampus; Infarction, Middle Cerebral Artery; Male; Mice; Molecular Targeted Therapy; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Protein Kinase C; Receptors, Opioid; Sodium-Potassium-Chloride Symporters; Stroke	2011
Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats. Pharmacological reports : PR, 2011, Volume: 63, Issue:5 Topics: Analgesics; Animals; Cardiovascular System; Enkephalins; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Respiratory System	2011
The analgesic activity of biphalin and its analog AM 94 in rats. European journal of pharmacology, 2012, Jun-15, Volume: 685, Issue:1-3 Topics: Analgesics; Animals; Disease Models, Animal; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Oligopeptides; Pain; Piperazines; Rats; Rats, Wistar; Time Factors	2012
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker. Journal of peptide science : an official publication of the European Peptide Society, 2013, Volume: 19, Issue:4 Topics: Analgesics; Animals; Enkephalins; Male; Mice; Morphine; Opioid Peptides; Protein Structure, Secondary; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu	2013
Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides. Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8 Topics: Analgesics, Opioid; Animals; Biological Assay; Drug Stability; Enkephalins; Humans; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship	2013
Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization. Chemical communications (Cambridge, England), 2014, Feb-07, Volume: 50, Issue:10 Topics: Chromatography; Crystallization; Enkephalins; Molecular Structure; Peptides	2014
The biological consequences of replacing D-Ala in biphalin with amphiphilic α-alkylserines. Chemical biology & drug design, 2014, Volume: 84, Issue:2 Topics: Analgesics; Animals; Brain; Enkephalins; Models, Molecular; Rats; Receptors, Opioid; Serine	2014
Potent biphalin analogs with µ/δ mixed opioid activity: in vivo and in vitro biological evaluation. Archiv der Pharmazie, 2014, Volume: 347, Issue:5 Topics: Analgesics, Opioid; Animals; Cells, Cultured; Enkephalins; Male; Molecular Structure; Pain; Protein Binding; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu	2014
Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: new potential treatment of abdominal pain associated with inflammatory bowel diseases. Peptides, 2014, Volume: 60 Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Enkephalins; Inflammation; Inflammatory Bowel Diseases; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred BALB C; Mustard Plant; Plant Oils; Trinitrobenzenesulfonic Acid	2014
The non-opioid receptor, antioxidant properties of morphine and the opioid peptide analog biphalin. Peptides, 2015, Volume: 63 Topics: Benzothiazoles; Enkephalins; Free Radical Scavengers; Free Radicals; Morphine; Receptors, Opioid; Sulfonic Acids	2015
Biphalin analogs containing β(3)-homo-amino acids at the 4,4' positions: Synthesis and opioid activity profiles. Peptides, 2015, Volume: 66 Topics: Amino Acids; Analgesics, Opioid; Animals; Enkephalins; Male; Pain; Peptides; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid, delta	2015
In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment. Brain research, 2015, Jun-03, Volume: 1609 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Brain Edema; Brain Infarction; Brain Ischemia; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Ischemia; Motor Activity; Neurons; Neuroprotective Agents; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reperfusion Injury; Severity of Illness Index; Stroke	2015
Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI). Neuropharmacology, 2016, Volume: 101 Topics: Analgesics; Analysis of Variance; Animals; Anxiety; Brain Injuries; Cognition Disorders; Disease Models, Animal; Enkephalins; Exploratory Behavior; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Recognition, Psychology; Silver Staining	2016
Mixed MOP/DOP agonist biphalin elicits anti-transit effect in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms. Pharmacological reports : PR, 2016, Volume: 68, Issue:1 Topics: Analgesics, Opioid; Animals; Diarrhea; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Gastrointestinal Motility; Irritable Bowel Syndrome; Male; Mice; Mice, Inbred BALB C; Organ Culture Techniques; Receptors, Opioid, delta; Receptors, Opioid, mu; Treatment Outcome	2016
An antihypertensive opioid: Biphalin, a synthetic non-addictive enkephalin analog decreases blood pressure in spontaneously hypertensive rats. Pharmacological reports : PR, 2016, Volume: 68, Issue:1 Topics: Analgesics, Opioid; Animals; Antihypertensive Agents; Blood Pressure; Enkephalins; Hypertension; Infusions, Intravenous; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY	2016
Biphalin preferentially recruits peripheral opioid receptors to facilitate analgesia in a mouse model of cancer pain - A comparison with morphine. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016, Jun-30, Volume: 89 Topics: Analgesia; Analgesics, Opioid; Animals; Blood-Brain Barrier; Cancer Pain; Cell Line, Tumor; Disease Models, Animal; Drug Tolerance; Enkephalins; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Opioid Peptides; Permeability; Quaternary Ammonium Compounds; Receptors, Opioid; Skin Neoplasms	2016
Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners. Neural plasticity, 2017, Volume: 2017 Topics: Animals; Cell Survival; Cells, Cultured; Enkephalins; Inflammation; Inflammation Mediators; Lipopolysaccharides; Male; Microglia; Neuralgia; Nitric Oxide; Nociception; Rats, Wistar; Receptors, Opioid	2017
Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers. Future medicinal chemistry, 2017, Volume: 9, Issue:9 Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fluorescein; Fluorescence; Fluorescent Dyes; Humans; Maleimides; Models, Molecular	2017
Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors. Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12 Topics: Cell Line; Cyclization; Enkephalins; Humans; Kinetics; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2018
The analgesic hybrid of dermorphin/substance P and analog of enkephalin improve wound healing in streptozotocin-induced diabetic rats. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2020, Volume: 28, Issue:2 Topics: Analgesics; Animals; Collagen; Diabetes Mellitus, Experimental; Enkephalins; Epidermal Cells; Fibroblasts; Macrophages; Male; Neovascularization, Physiologic; Opioid Peptides; Peptide Fragments; Rats; Rats, Wistar; Substance P; Wound Healing	2020
Solution Phase Peptide Synthesis: The Case of Biphalin. Methods in molecular biology (Clifton, N.J.), 2020, Volume: 2103 Topics: Chemistry Techniques, Synthetic; Enkephalins; Esters; Hydrolysis; Molecular Structure; Peptides; Solutions; Structure-Activity Relationship	2020
Biphalin, a dimeric opioid peptide, reduces neonatal hypoxia-ischemia brain injury in mice by the activation of PI3K/Akt signaling pathway. Journal of chemical neuroanatomy, 2021, Volume: 115 Topics: Animals; Brain; Disease Models, Animal; Enkephalins; Hypoxia-Ischemia, Brain; Mice; Narcotic Antagonists; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Polyethylene Terephthalates; Proto-Oncogene Proteins c-akt; Signal Transduction	2021
The opioid peptide biphalin modulates human corneal epithelial wound healing in vitro. Journal francais d'ophtalmologie, 2021, Volume: 44, Issue:9 Topics: Cell Movement; Cells, Cultured; Corneal Injuries; Enkephalins; Epithelium, Corneal; Humans; Opioid Peptides; Wound Healing	2021
Glutamate Buffering Capacity and Blood-Brain Barrier Protection of Opioid Receptor Agonists Biphalin and Nociceptin. The Journal of pharmacology and experimental therapeutics, 2021, Volume: 379, Issue:3 Topics: Analgesics; Analgesics, Opioid; Animals; Animals, Newborn; Blood-Brain Barrier; Capillary Permeability; Coculture Techniques; Dose-Response Relationship, Drug; Enkephalins; Glutamic Acid; Mice; Neuroprotective Agents; Nociceptin; Opioid Peptides; Receptors, Opioid	2021