enkephalin, leucine has been researched along with beta-funaltrexamine in 120 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (26.67) | 18.7374 |
| 1990's | 80 (66.67) | 18.2507 |
| 2000's | 7 (5.83) | 29.6817 |
| 2010's | 1 (0.83) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kameyama, T; Toyoshi, T; Ukai, M | 5 |
| Tang, RR; Tseng, LF | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Franklin, TG; Traynor, JR | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY | 1 |
| Chalmers, J; Drolet, G; Morilak, DA | 2 |
| Mjanger, E; Yaksh, TL | 1 |
| Collins, JG; Kitahata, LM; Nakatani, K; Omote, K | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 1 |
| Billington, CJ; Grace, M; Levine, AS | 1 |
| Lu, CL; Shaikh, MB; Siegel, A | 1 |
| Cowan, A; Li, SX; Liu-Chen, LY; Wheeler-Aceto, H | 1 |
| Butler, B; Gunion, MW; Miller, S; Moore, RD; Morley, JE; Rosenthal, MJ; Zib, B | 1 |
| Shiotsu, G; Stein, L; Stevens, KE | 1 |
| Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL | 1 |
| Duckles, SP; Li, YJ | 1 |
| Fischbach, PS; McCleskey, EW; Schroeder, JE; Zheng, D | 1 |
| Pasternak, GW; Paul, D; Pick, CG | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 2 |
| Dixon, DM; Traynor, JR | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY; Rohrbach, KW | 1 |
| Suh, HH; Tseng, LF | 1 |
| Fuentes, JA; Iglesias, T; Jiménez, I | 1 |
| Mosberg, HI; Porreca, F; Qi, JA | 1 |
| Delle, M; Hoffmann, P; Thorén, P | 1 |
| Cowan, A; Murray, CW | 1 |
| Brady, LS; Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 1 |
| Dickenson, AH; Roques, BP; Sullivan, AF | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Garzón, J; Sánchez-Blázquez, P | 2 |
| Huidobro-Toro, JP; Li, CH; Valenzuela, R | 1 |
| Pasternak, GW; Recht, LD | 1 |
| Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F | 1 |
| Kunos, G; Mosqueda-Garcia, R | 1 |
| Smith, CB | 1 |
| Herz, A; Höllt, V; Morris, BJ | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 1 |
| Koenig, JI; Krulich, L; Moss, RL; Wiesner, JB | 1 |
| Holaday, JW; Robles, L; Tortella, FC | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Holtzman, SG; Locke, KW | 2 |
| Liu-Chen, LY; Tam, SW | 1 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Kavaliers, M | 1 |
| Pert, CB; Rothman, RB; Schumacher, UK | 1 |
| Holaday, JW; Tortella, FC | 1 |
| Bennett-Kelly, L; Smith, CB; Woods, JH | 1 |
| Takemori, AE; Ward, SJ | 2 |
| Herz, A; Schulz, R; Wüster, M | 1 |
| Belenky, GL; Gelinas-Sorell, D; Holaday, JW; Kenner, JR | 1 |
| D'Amato, RJ; Holaday, JW | 1 |
| Cowan, A; Holaday, JW; Robles, LE; Tortella, FC | 1 |
| D'Amato, R; Holaday, JW | 1 |
| Koenig, JI; Krulich, L; Mayfield, MA; McCann, SM | 1 |
| Fukuda, K; Fukushima, N; Misu, Y; Miyamae, T; Sasaki, Y; Takeshima, H; Ueda, H | 1 |
| Armstead, WM | 1 |
| Imai, Y; Schäfer, M; Stein, C; Uhl, GR | 1 |
| Fujinami, T; Nishimura, M; Saeki, T; Sato, N; Watanabe, Y | 1 |
| Gong, QZ; Hamm, RJ; Jiang, JY; Lyeth, BG; Young, HF | 1 |
| Endoh, T; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Chen, C; Chen, YW; Kim de Riel, J; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M; Saitoh, A; Suzuki, T | 1 |
| Randić, M; Wang, RA | 1 |
| Noble, F; Roques, BP | 1 |
| Adams, JU; Li, S; Liu-Chen, LY; Yang, HH | 1 |
| Elliott, J; Lambert, DG; Smart, D; Traynor, JR | 2 |
| Dworkin, SI; Martin, TJ; Smith, JE | 2 |
| Ingenito, AJ; Wong, SC | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Connelly, CD; Martinez, RP; Porreca, F; Raffa, RB; Schupsky, JJ | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Kameyama, T; Mizutani, M; Ukai, M | 1 |
| Kameyama, T; Mizutani, M; Sasaki, Y; Toyoshi, T; Ukai, M | 1 |
| Kwok, YN; McIntosh, C; Yago, V | 1 |
| Eisenberg, RM | 2 |
| Callahan, P; Janik, J; Klosterman, S; Parman, R | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Cai, YP; Yu, LC | 1 |
| Innes, DG; Kavaliers, M | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Callahan, P; Janik, J; Kehoe, L; Parman, R | 1 |
| Cowan, A; Hunter, JC; Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Wheeler-Aceto, H | 1 |
| Davenport, KE; Houdi, AA; Marson, L; Van Loon, GR | 1 |
| Gouardères, C; Jhamandas, K; Sutak, M; Zajac, JM | 1 |
| Bodnar, RJ; Cole, JL; Leventhal, L | 1 |
| Kovacević-Jovanović, V; Mancev, Z; Pesić, G; Radulović, J; Stanojević, S; Vasiljević, T | 1 |
| Chao, CC; Gekker, G; Hu, S; Lipovsky, MM; Molitor, TW; Peterson, PK; Sowa, G | 1 |
| Bodnar, RJ; Leventhal, L; Pasternak, GW; Rossi, GC; Stevens, LB | 1 |
| Childers, SR; deMontis, MG; Martin, TJ; Selley, DE; Sim, LJ | 1 |
| Gross, GJ; Hsu, AK; Schultz, JE | 1 |
| DeMontis, MG; Dworkin, SI; Kim, SA; Martin, TJ; Sizemore, GM; Smith, JE | 1 |
| Fujimoto, JM; Gorny, JM; Rady, JJ | 1 |
| Arcaya, JL; Cano, G; Gómez, G; Maixner, W; Suárez-Roca, H | 1 |
| Kowalski, J | 1 |
| Fujimura, T; Kastin, AJ; Katsuyama, S; Murayama, K; Sakurada, S; Sakurada, T; Ueda, H; Yuki, M; Zadina, JE | 1 |
| Cui, RY; Jiang, CL; Liu, XY; Lu, CL; Son, LX; Sun, LY; Wang, YX; You, ZD | 1 |
| Freeman, FM; Young, IG | 1 |
| Brailoiu, GC; Dun, NJ; Ohtubo, Y; Wu, SY | 1 |
| Raffa, RB; Sterious, SN; Walker, EA | 1 |
| Bourgoin, S; Glowinski, J; Godeheu, G; Jabourian, M; Kemel, ML; Ozon, S; Pérez, S; Venance, L | 1 |
| Farrell, PA; Loomis, JL; Rodd, DW | 1 |
| Mascagni, F; McDonald, AJ; Primeaux, SD; Wilson, MA; Wilson, SP | 1 |
| Cline, MA; Hiramatsu, K; Sugahara, K; Tachibana, T; Ueda, H | 1 |
| Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Marszalek-Grabska, M; Witkowska, E | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
1 trial(s) available for enkephalin, leucine and beta-funaltrexamine
| Article | Year |
|---|---|
Influence of opioids in hypothalamic nuclei on cold thermogenesis of lean and obese LA/N-cp rats.
Topics: Animals; Cold Temperature; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity; Opioid Peptides; Oxygen Consumption; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Stress, Physiological; Thermogenesis | 1994 |
119 other study(ies) available for enkephalin, leucine and beta-funaltrexamine
| Article | Year |
|---|---|
Effects of [D-Ala2, D-Leu5]enkephalin and [D-Pen2, L-Pen5]enkephalin on apomorphine-induced motor activity in the mouse.
Topics: Analgesics; Animals; Apomorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Grooming; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1992 |
Pentobarbital attenuates antinociception induced by i.c.v. morphine but not beta-endorphin in the mouse.
Topics: Animals; beta-Endorphin; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pentobarbital; Receptors, Opioid | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
Alkylation with beta-funaltrexamine suggests differences between mu-opioid receptor systems in guinea-pig brain and myenteric-plexus.
Topics: Alkylating Agents; Alkylation; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Naltrexone; Receptors, Opioid, mu | 1991 |
Autoradiographic study of irreversible binding of [3H]beta-funaltrexamine to opioid receptors in the rat forebrain: comparison with mu and delta receptor distribution.
Topics: Animals; Autoradiography; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Telencephalon; Tritium | 1991 |
Endogenous opioids tonically inhibit the depressor neurones in the caudal ventrolateral medulla of rabbits: mediation through delta- and kappa-receptors.
Topics: Amino Acid Sequence; Animals; Endorphins; Enkephalin, Leucine; Hemodynamics; Male; Medulla Oblongata; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1991 |
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil | 1991 |
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Cross-tolerance studies in the spinal cord of beta-FNA-treated mice provides further evidence for delta opioid receptor subtypes.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
DAGO ([D-Ala2,N-Me-Phe4,Gly-ol]enkephalin) specifically reverses apomorphine-induced increase in rearing and grooming behaviors in the mouse.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Grooming; Injections, Intraventricular; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Beta-funaltrexamine (beta-FNA) decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Feeding Behavior; Food Deprivation; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
An enkephalinergic mechanism involved in amygdaloid suppression of affective defence behavior elicited from the midbrain periaqueductal gray in the cat.
Topics: Affect; Aggression; Amygdala; Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalins; Female; Fluorescent Dyes; Homocysteine; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Stilbamidines | 1991 |
Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Time Factors; Tritium | 1991 |
mu-receptor mediates elevated glucose and corticosterone after third ventricle injection of opioid peptides.
Topics: Animals; beta-Endorphin; Blood Glucose; Cerebral Ventricles; Corticosterone; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fatty Acids, Nonesterified; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration | 1991 |
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1991 |
Effect of opioid receptor antagonists on vasodilator nerve actions in the perfused rat mesentery.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanethidine; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Vasodilation | 1991 |
[D-Ala2,NMePhe4,Gly-ol5]enkephalin, but not [D-Pen2,L-Pen5]enkephalin, specifically inhibits behaviors induced by the dopamine D2 agonist RU 24213.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Motor Activity; Naltrexone; Phenethylamines | 1991 |
Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Mollusk Venoms; Naltrexone; Narcotic Antagonists; omega-Conotoxin GVIA; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
Topics: Animals; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Up-Regulation | 1990 |
Tonic opioid inhibition of the pressor region of the rostral ventrolateral medulla of rabbits is mediated by delta receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Hemodynamics; Male; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Pressoreceptors; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid | 1990 |
[3H] beta-funaltrexamine ([3H] beta-FNA) binds irreversibly to mu opioid receptors in the rat brain: autoradiographic study.
Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Delta but not mu-opioid receptors in the spinal cord are involved in antinociception induced by beta-endorphin given intracerebroventricularly in mice.
Topics: Analgesia; Animals; beta-Endorphin; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological | 1990 |
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective delta agonist in vivo.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Role of opioid receptors in the long-lasting blood pressure depression after electric muscle stimulation in the hind leg of the rat.
Topics: Animals; Benzomorphans; Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart Rate; Hindlimb; Male; Naloxone; Naltrexone; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Receptors, Opioid; Regional Blood Flow | 1990 |
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior | 1990 |
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
Topics: Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Delta-opioid mediated inhibitions of acute and prolonged noxious-evoked responses in rat dorsal horn neurones.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Evoked Potentials; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Lack of mixed agonist-antagonist properties of [Gln8-Gly31]-beta h-EP-Gly-Gly-NH2 and [Arg9,19,24,28,29]-beta h-EP in the rat vas deferens neuroeffector junction: studies with naloxone, beta-funaltrexamine and ICI 174,864.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neuroeffector Junction; Rats; Rats, Inbred Strains; Vas Deferens | 1989 |
Effects of beta-funaltrexamine on radiolabeled opioid binding.
Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1987 |
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
Topics: Animals; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Opioid analgesia in the mouse: evidence for multiple receptors using beta-FNA.
Topics: Analgesia; Animals; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid | 1986 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
Opioid gene expression in rat striatum is modulated via opioid receptors: evidence from localized receptor inactivation.
Topics: Animals; Corpus Striatum; Enkephalins; Gene Expression Regulation; Male; Naltrexone; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; RNA, Messenger | 1988 |
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
Topics: Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Lack of evidence for epsilon-opioid receptors in the rat vas deferens.
Topics: Animals; Calcium; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1988 |
Possible delta receptor mediation of the effect of beta-endorphin on luteinizing hormone (LH) release, but not on prolactin (PRL) release, in the ovariectomized rat.
Topics: Animals; beta-Endorphin; Castration; Endorphins; Enkephalin, Leucine; Female; Kinetics; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
Behavioral effects of opioid peptides selective for mu or delta receptors. I. Morphine-like discriminative stimulus effects.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine Dependence; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Evidence for opioid and non-opioid forms of stress-induced analgesia in the snail, Cepaea nemoralis.
Topics: Animals; Cold Temperature; Endorphins; Enkephalin, Leucine; Hot Temperature; Naloxone; Naltrexone; Pain; Reaction Time; Snails; Stress, Physiological | 1987 |
Effect of beta-FNA on opiate delta receptor binding.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Oligopeptides; Protein Conformation; Rats; Receptors, Opioid | 1984 |
Mu and delta opioid receptor interactions in a rat model of drug induced seizures.
Topics: Animals; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1984 |
Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1984 |
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid | 1983 |
Evidence for delta-receptor involvement in the post-ictal antinociceptive responses to electroconvulsive shock in rats.
Topics: Animals; Electroshock; Enkephalin, Leucine; Escape Reaction; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Multiple opioid receptors: evidence for mu-delta binding site interactions in endotoxic shock.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Heart Rate; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pulse; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Shock, Septic | 1983 |
ICI 154,129, a delta-opioid receptor antagonist raises seizure threshold in rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Multiple opioid receptors in endotoxic shock: evidence for delta involvement and mu-delta interactions in vivo.
Topics: Allosteric Regulation; Animals; Blood Pressure; Enkephalin, Leucine; Macromolecular Substances; Male; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Shock, Septic | 1984 |
Differential role of the opioid mu and delta receptors in the activation of prolactin (PRL) and growth hormone (GH) secretion by morphine in the male rat.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Growth Hormone; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Female; GTP-Binding Proteins; Naltrexone; Oocytes; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases; Xenopus laevis | 1995 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia.
Topics: Amino Acid Sequence; Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Foot; Ganglia, Spinal; Inflammation; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu; Ribonucleases; RNA, Messenger | 1995 |
Electrophysiological demonstration and activation of mu-opioid receptors in the rabbit sinoatrial node.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Fentanyl; Microelectrodes; Naltrexone; Narcotic Antagonists; Narcotics; Patch-Clamp Techniques; Rabbits; Receptors, Opioid, mu; Sinoatrial Node | 1995 |
Effects of mu opioid agonist and antagonist on neurological outcome following traumatic brain injury in the rat.
Topics: Animals; Brain Injuries; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Treatment Outcome | 1995 |
Effects of a highly selective nonpeptide delta opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice.
Topics: Analgesics; Animals; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Nociceptors; Oligopeptides; Quinolines; Receptors, Opioid, delta | 1995 |
Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Glycosylation; Molecular Sequence Data; Naltrexone; Oligopeptides; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sodium; Tritium | 1995 |
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin | 1995 |
Activation of mu-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons.
Topics: Action Potentials; Amino Acid Sequence; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Sequence Data; Muscimol; Naloxone; Naltrexone; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Spinal Cord | 1994 |
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu | 1995 |
Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium | 1995 |
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
Topics: Amino Acid Sequence; Animals; Brain Neoplasms; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured | 1994 |
Alkylation of mu opioid receptors by beta-funaltrexamine in vivo: comparison of the effects on in situ binding and heroin self-administration in rats.
Topics: Alkylation; Animals; Behavior, Animal; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; In Vitro Techniques; Injections, Intraventricular; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Self Administration | 1995 |
Influence of hypertension development on rat tail artery responses to opioid peptides.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Tail; Vasoconstriction | 1995 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
Topics: Animals; Benzimidazoles; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, mu; Spinal Cord | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides | 1994 |
Differential modulation of behavioral responses by [D-Ala2, NMePhe4, Gly-ol]enkephalin, [D-Ala2] deltorphin II and [D-Pen2, L-Pen5]enkephalin in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Naltrexone; Oligopeptides | 1994 |
Beta-funaltrexamine blockade of opioid-induced inhibition of somatostatin secretion from rat stomach.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Radioimmunoassay; Rats; Rats, Wistar; Somatostatin | 1994 |
TRIMU-5, a mu 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis.
Topics: Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Kinetics; Male; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1994 |
Multiple opiate receptor subtypes are involved in the stimulation of growth hormone release by beta-endorphin in female rats.
Topics: Animals; beta-Endorphin; Diestrus; Enkephalin, Leucine; Female; Growth Hormone; Kinetics; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Effects of opioid receptors antagonists administration to suprachiasmatic nucleus on hibernation of ground squirrels Citellus dauricus.
Topics: Animals; Endorphins; Enkephalin, Leucine; Female; Hibernation; Injections; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sciuridae; Suprachiasmatic Nucleus | 1993 |
Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine.
Topics: Analgesics; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Effects of intracerebroventricular administration of beta-funaltrexamine on [3H]DAMGO binding to rat brain sections.
Topics: Animals; Autoradiography; Brain Mapping; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu | 1993 |
DAMGO ([D-Ala2,NMePhe4,Gly-ol]enkephalin), but not DPLPE ([D-Pen2,L- Pen5]enkephalin), specifically inhibits methamphetamine-induced behavioral responses in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Methamphetamine; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists | 1993 |
Sex differences in the antinociceptive effects of the enkephalinase inhibitor, SCH 34826.
Topics: Analgesia; Analgesics; Animals; Dioxolanes; Dipeptides; Enkephalin, Leucine; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Peromyscus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Sex Characteristics; Stress, Psychological | 1993 |
Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice.
Topics: Analgesics; Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Time Factors; Virulence Factors, Bordetella | 1993 |
DAMGO stimulates the hypothalamo-pituitary-adrenal axis through a mu-2 opioid receptor.
Topics: Analgesics; Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Opiate receptor subtype involvement in the stimulation of prolactin release by beta-endorphin in female rats.
Topics: Animals; beta-Endorphin; Diestrus; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Lactation; Male; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1993 |
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Oxidopamine; Peptide Fragments; Receptors, Opioid | 1995 |
Effects of beta-FNA on sympathoadrenal, cardiovascular, and analgesic responses to DAMPGO at rest and during stress.
Topics: Adrenal Glands; Analgesics; Animals; Blood Pressure; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heart Rate; Hemodynamics; Male; Naltrexone; Narcotic Antagonists; Organ Size; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stress, Psychological; Sympathetic Nervous System | 1996 |
Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 1996 |
Reductions in locomotor activity following central opioid receptor subtype antagonists in rats.
Topics: Animals; Enkephalins; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley | 1996 |
Modulation of humoral immune response by central administration of leucine-enkephalin: effects of mu, delta and kappa opioid receptor antagonists.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antibody-Producing Cells; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hemolytic Plaque Technique; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine.
Topics: Animals; Cryptococcus neoformans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Microglia; Morphine; Naltrexone; Narcotics; Phagocytosis; Swine | 1997 |
Antisense mapping of the MOR-1 opioid receptor clone: modulation of hyperphagia induced by DAMGO.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperphagia; Male; Naltrexone; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Effects of intracerebroventricular administration of beta-funaltrexamine on DAMGO-stimulated [35S]GTP-gamma-S binding in rat brain sections.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sulfur Radioisotopes | 1997 |
Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections.
Topics: Analgesics, Opioid; Animals; Brain; Caudate Nucleus; Cocaine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Heroin Dependence; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Opioid, mu; Self Administration | 1998 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Pain; Receptors, Opioid, mu; Time Factors | 1999 |
Analgesic effect of interferon-alpha via mu opioid receptor in the rat.
Topics: Analgesia; Animals; Antibodies, Monoclonal; Cell Line; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Injections, Intraventricular; Interferon Type I; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Proteins | 2000 |
Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
Topics: Age Factors; Amnesia; Analgesics, Opioid; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Chickens; Chloramphenicol; Conditioning, Psychological; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Female; Male; Memory; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Protein Synthesis Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 2000 |
Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices.
Topics: Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; Female; Male; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Tetrodotoxin; Time Factors | 2003 |
Opioid receptors and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Functional mu opioid receptors are expressed in cholinergic interneurons of the rat dorsal striatum: territorial specificity and diurnal variation.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Blotting, Northern; Choline O-Acetyltransferase; Circadian Rhythm; Corpus Striatum; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; Immunohistochemistry; In Vitro Techniques; Interneurons; Limbic System; Membrane Potentials; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Potassium; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptosomes; Tritium | 2005 |
The role of delta opioid receptors in the anxiolytic actions of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Enkephalins; Male; Maze Learning; Naltrexone; Rats; Rats, Long-Evans; Receptors, GABA-A; Receptors, Opioid, delta | 2006 |
Central administration of somatostatin stimulates feeding behavior in chicks.
Topics: Alkylating Agents; Animals; Animals, Newborn; Chickens; Eating; Enkephalin, Leucine; Hormones; Male; Naltrexone; Narcotic Antagonists; Neuropeptides; Receptors, Opioid; Somatostatin | 2009 |
Enkephalin analog, cyclo[N(ε),N(β)-carbonyl-D-Lys(2),Dap(5)] enkephalinamide (cUENK6), inhibits the ethanol withdrawal-induced anxiety-like behavior in rats.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Enkephalin, Leucine; Enkephalins; Ethanol; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2015 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |