enkephalin, leucine has been researched along with alanine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alberti, KG; Besser, GM; Bloom, SR; Delitala, G; Edwards, CR; Jeffcoate, WJ; Jones, A; Ratter, SJ; Stubbs, WA | 1 |
| Demonté, JP; Englert, A; Guillard, R; Prémilat, S | 1 |
| Goodman, M; Said-Nejad, OE; Schiller, PW; Yamazaki, T | 1 |
| Goodman, M; Mierke, DF; Said-Nejad, OE; Schiller, PW | 1 |
| Aoyagi, H; Costa, T; Izumiya, N; Kato, T; Lee, S; Mihara, H; Shimohigashi, Y | 2 |
| George, SR; O'Dowd, BF; Pak, Y | 1 |
| Coric, P; Fournié-Zaluski, MC; Maldonado, R; Noble, F; Roques, BP; Smadja, C; Turcaud, S; Valverde, O | 1 |
| Bühling, F; Höllt, V; Klutzny, M; Koch, T; Raulf, E; Schröder, H; Schulz, S; Wolf, R | 1 |
| Ho, MK; Wong, YH | 1 |
| Goodman, M; Rew, Y; Zapf, C | 1 |
| Cassel, JA; Chung, NN; DeHaven, RN; Goodman, M; Malkmus, S; Rew, Y; Schiller, PW; Svensson, C; Taulane, JP; Yaksh, TL | 1 |
| Goodman, M; Malkmus, S; Rew, Y; Schiller, PW; Svensson, CI; Taulane, JP; Yaksh, TL | 1 |
| Chaipatikul, V; Law, PY; Loh, HH | 1 |
| Cournoyer, J; Demee, M; Fang, L; Sierra, T; Yan, B; Young, C | 1 |
| HANSON, HT; SMITH, EL | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
| Fichna, J; Giełdoń, A; Kamysz, E; Sobocińska, M | 1 |
1 review(s) available for enkephalin, leucine and alanine
| Article | Year |
|---|---|
New reagents, reactions, and peptidomimetics for drug design.
Topics: Alanine; Amines; Amino Acids; Drug Design; Enkephalins; Guanidine; Indicators and Reagents; Models, Chemical; Organophosphates; Peptides; Sulfides; Triazines | 2001 |
1 trial(s) available for enkephalin, leucine and alanine
| Article | Year |
|---|---|
Hormonal and metabolic responses to an enkephalin analogue in normal man.
Topics: Adrenocorticotropic Hormone; Adult; Alanine; Blood Glucose; Clinical Trials as Topic; Endorphins; Enkephalins; Follicle Stimulating Hormone; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glycerol; Growth Hormone; Humans; Hydrocortisone; Injections, Intravenous; Insulin; Luteinizing Hormone; Male; Pituitary Hormones, Anterior; Prolactin; Research Design; Thyrotropin | 1978 |
16 other study(ies) available for enkephalin, leucine and alanine
| Article | Year |
|---|---|
Theoretical conformational analysis of three [Trp4, Met5]-enkephalin analogs related to non-radiative energy transfer [proceedings].
Topics: Alanine; Endorphins; Energy Transfer; Enkephalins; Glycine; Methionine; Protein Conformation; Structure-Activity Relationship; Tryptophan | 1979 |
Conformational studies of stereoisomeric 14-membered cyclic enkephalin analogues containing 1-naphthylalanine at the fourth position: chirality effect of leucine at the fifth position on biological activity and receptor selectivity.
Topics: Alanine; Amino Acid Sequence; Enkephalins; Leucine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Protein Conformation; Receptors, Opioid; Spectrum Analysis; Structure-Activity Relationship; Temperature | 1991 |
Enkephalin analogues containing beta-naphthylalanine at the fourth position.
Topics: Alanine; Amino Acid Sequence; Animals; beta-Alanine; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Protein Conformation; Receptors, Opioid | 1990 |
Delta and mu opiate receptor probes: fluorescent enkephalins with high receptor affinity and specificity.
Topics: Alanine; Enkephalins; Fluorescent Dyes; Pyrenes; Receptors, Opioid; Spectrometry, Fluorescence | 1985 |
Tyr1-substituted and fluorescent Pya1-enkephalins bind strongly and selectively to mu and delta opiate receptors.
Topics: Alanine; Animals; Binding, Competitive; Crystallography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Pyrenes; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spectrometry, Fluorescence; Structure-Activity Relationship; Tyrosine | 1986 |
Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail.
Topics: Alanine; Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Point Mutation; Rats; Receptors, Opioid, mu; Recombinant Proteins; Serine; Threonine; Transfection | 1997 |
Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.
Topics: Administration, Oral; Alanine; Animals; Disulfides; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalins; Enzyme Inhibitors; Hot Temperature; Inflammation; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1997 |
Replacement of threonine 394 by alanine facilitates internalization and resensitization of the rat mu opioid receptor.
Topics: Alanine; Amino Acid Substitution; Analgesics, Opioid; Animals; Cyclic AMP; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation, Neoplastic; Mutation; Rats; Receptors, Cell Surface; Receptors, Opioid, mu; Threonine; Tumor Cells, Cultured | 1999 |
Alanine-23 of transducin alpha subunit is involved in defining the affinity for betagamma complex.
Topics: Alanine; Analgesics; Antisense Elements (Genetics); Cells, Cultured; Cyclic AMP; Enkephalins; GTP-Binding Proteins; Humans; Kidney; Models, Molecular; Mutagenesis; Phenotype; Protein Conformation; Stimulation, Chemical; Transducin; Transfection | 1999 |
Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.
Topics: Alanine; Analgesics; Animals; CHO Cells; Cricetinae; Enkephalins; Escape Reaction; Humans; Ileum; In Vitro Techniques; Injections, Spinal; Male; Mice; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfides; Swine; Vas Deferens | 2002 |
Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog.
Topics: Alanine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord; Sulfides | 2003 |
Ligand-selective activation of mu-oid receptor: demonstrated with deletion and single amino acid mutations of third intracellular loop domain.
Topics: Adenylyl Cyclases; Alanine; Analgesics, Opioid; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Deletion; Humans; Membrane Proteins; Morphine; Narcotic Antagonists; Pertussis Toxin; Protein Structure, Tertiary; Receptors, Opioid, mu | 2003 |
Parallel high-throughput accurate mass measurement using a nine-channel multiplexed electrospray liquid chromatography ultraviolet time-of-flight mass spectrometry system.
Topics: Alanine; Calibration; Chromatography, Liquid; Enkephalin, Leucine; Molecular Weight; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2003 |
Action of peptidases of beta-alanine peptides.
Topics: Alanine; beta-Alanine; Brain; Enkephalins; Humans; Hydrolases; Peptide Hydrolases; Peptides; Protein Precursors; Proteins | 1948 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |
Alanine scan of sialorphin and its hybrids with opiorphin: synthesis, molecular modelling and effect on enkephalins degradation.
Topics: Acetylation; Alanine; Amino Acid Sequence; Enkephalin, Methionine; Enkephalins; Models, Molecular; Neprilysin; Oligopeptides; Peptides; Protein Binding; Protein Conformation; Proteolysis; Salivary Proteins and Peptides; Solid-Phase Synthesis Techniques | 2018 |