enkephalin, leucine and adenosine

enkephalin, leucine has been researched along with adenosine in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19907 (21.21)18.7374
1990's17 (51.52)18.2507
2000's8 (24.24)29.6817
2010's1 (3.03)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heller, PH; Levine, JD; Taiwo, YO1
DeLander, GE; Mosberg, HI; Porreca, F1
Bucher, B; Corriu, C; Stoclet, JC1
Berry-Kravis, E; Dawson, G; Derechin, V; Kazmierczak, BI1
Hogenboom, F; Mulder, AH; Schoffelmeer, AN1
Law, PY; Loh, HH; Louie, AK1
Weiner, N1
Holmgren, S1
Lagercrantz, H1
Elliott, J; Jhamandas, K; Notman, H; Sutak, M1
Green, PG; Heller, PH; Khasar, SG; Levine, JD; Taiwo, YO; Wang, JF1
Delander, GE; Keil, GJ1
Cahill, CM; Sawynok, J; White, TD2
Cole, RL; Green, D; Grossbard, SJ; Hyman, SE; Konradi, C; Leveque, JC; Pollack, AE; Senatus, P1
Schiffmann, SN; Vanderhaeghen, JJ2
Manabe, T; Manzoni, OJ; Nicoll, RA1
De Lander, GE; Keil, GJ1
Aley, KO; Green, PG; Levine, JD1
Lambert, NA; Wilson, WA1
Armstead, WM1
Aley, KO; Levine, JD1
Fredholm, BB; Svenningsson, P1
Aoyama, S; Borrelli, E; Kase, H1
Beilstein, MA; Chen, JF; Cuellar, B; Fink, JS; Grandy, DK; Hackett, E; Impagnatiello, F; Low, MJ; Moratalla, R; Ongini, E; Rubinstein, M; Schwarzschild, MA1
Bantubungi, K; Blum, D; d'Alcantara, P; Galas, MC; Gall, D; Schiffmann, SN1
Konieczny, J; Pietraszek, M; Wardas, J1
Christie, MJ; Hack, SP; Vaughan, CW1
Díaz-Ruiz, O; Ferré, S; Goldberg, SR; Hope, BT; Karcz-Kubicha, M; Morales, M; Quiroz-Molina, C1
Aguilar, E; Bové, J; Cortés, R; Marin, C; Mengod, G; Serrats, J1
Cunha, RA; Ferré, S; Fisone, G; Moresco, R; Schiffmann, SN1
Maruyama, M; Nishiyama, K; Ohta, H; Suzuki, H; Yoshihara, T1

Reviews

3 review(s) available for enkephalin, leucine and adenosine

ArticleYear
The role of cyclic nucleotides in the regulation of neurotransmitter release from adrenergic neurons by neuromodulators.
    Essays in neurochemistry and neuropharmacology, 1980, Volume: 4

    Topics: Acetylcholine; Adenosine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Angiotensin II; Animals; Calcium; Cyclic AMP; Dopamine; Enkephalins; Exocytosis; Histamine; Humans; Neurotransmitter Agents; Norepinephrine; Nucleotides, Cyclic; Oxidative Phosphorylation; Prostaglandins; Protein Kinases; Sympathetic Nervous System

1980
Classical and 'new' neurotransmitters during development--some examples from control of respiration.
    Journal of developmental physiology, 1984, Volume: 6, Issue:3

    Topics: Adenosine; Animals; Asphyxia Neonatorum; Central Nervous System; Delivery, Obstetric; Enkephalins; Growth; Humans; Infant, Newborn; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Neurotransmitter Agents; Norepinephrine; Rats; Respiratory Physiological Phenomena; Substance P

1984
Adenosine A2A receptors and basal ganglia physiology.
    Progress in neurobiology, 2007, Volume: 83, Issue:5

    Topics: Adenosine; Animals; Basal Ganglia; Enkephalins; gamma-Aminobutyric Acid; Humans; Neural Pathways; Neurons; Receptor, Adenosine A2A; Receptors, Neurotransmitter; Synaptic Transmission

2007

Other Studies

30 other study(ies) available for enkephalin, leucine and adenosine

ArticleYear
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
    Neuroscience, 1992, Volume: 48, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes

1992
Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: dissociation from gastrointestinal effects in mice.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3

    Topics: Adenosine; Analgesia; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Emptying; Gastrointestinal Motility; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Receptors, Opioid; Spinal Cord; Theophylline

1992
Prejunctional opioid mu-receptors and adenosine A1-receptors on the sympathetic nerve endings of the rat tail artery interact with the alpha 2-adrenoceptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:1

    Topics: Adenosine; Adrenergic alpha-Agonists; Animals; Arteries; Autonomic Fibers, Postganglionic; Electric Stimulation; Enkephalins; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Receptors, Purinergic; Tail; Vasodilator Agents

1992
Neuromodulator-mediated phosphorylation of specific proteins in a neurotumor hybrid cell line (NCB-20).
    Journal of neurochemistry, 1988, Volume: 50, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Alprostadil; Animals; Brain; Calcimycin; Colforsin; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Immunoassay; Mice; Nerve Tissue Proteins; Neuroblastoma; Neurotransmitter Agents; Phosphoproteins; Phosphorylation; Protein Kinases; Serotonin; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase

1988
Inhibition of dopamine-sensitive adenylate cyclase by opioids: possible involvement of physically associated mu- and delta-opioid receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 335, Issue:3

    Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Corpus Striatum; Cyclic AMP; Dopamine Antagonists; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Isoproterenol; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vasoactive Intestinal Peptide

1987
Molecular mechanisms of opiate tolerance and dependence in a clonal cell line.
    NIDA research monograph, 1985, Volume: 62

    Topics: Adenosine; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Naloxone; Narcotics; Nerve Tissue Proteins; Substance-Related Disorders

1985
The effects of putative non-adrenergic, non-cholinergic autonomic transmitters on isolated strips from the stomach of the rainbow trout. Salmo gairdneri.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1983, Volume: 74, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Animals; Bombesin; Enkephalins; Muscle Contraction; Muscle, Smooth; Neurotensin; Neurotransmitter Agents; Serotonin; Somatostatin; Stomach; Structure-Activity Relationship; Substance P; Trout; Vasoactive Intestinal Peptide

1983
Antagonism of enkephalin action on acetylcholine release by methylxanthines: lack of a purine link.
    British journal of pharmacology, 1983, Volume: 80, Issue:4

    Topics: Acetylcholine; Adenosine; Animals; Caffeine; Cerebral Cortex; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Rats; Theophylline; Xanthines

1983
Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?
    Neuroscience, 1995, Volume: 67, Issue:1

    Topics: Adenosine; Adenylate Cyclase Toxin; Amino Acid Sequence; Analgesics; Animals; Antihypertensive Agents; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Hyperalgesia; Male; Molecular Sequence Data; Pertussis Toxin; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Virulence Factors, Bordetella

1995
Time-dependent antinociceptive interactions between opioids and nucleoside transport inhibitors.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:3

    Topics: Adenosine; Analgesics; Animals; Biological Transport; Dilazep; Dipyridamole; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Narcotics; Nucleosides; Receptors, Opioid; Thioinosine; Time Factors

1995
Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of opioid subtypes.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: Adenosine; Analgesics; Animals; Behavior, Animal; Caffeine; Calcium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nociceptors; Oligopeptides; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Synaptosomes

1995
Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Sequence; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enhancer Elements, Genetic; Enkephalins; Fetus; Genes, fos; Molecular Sequence Data; Phosphorylation; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Transcription Factor AP-1

1995
Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Corpus Striatum; Enkephalins; Gene Expression Regulation; Globus Pallidus; Neurons; Oxidopamine; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Purinergic; Substance P; Substantia Nigra

1993
Release of adenosine by activation of NMDA receptors in the hippocampus.
    Science (New York, N.Y.), 1994, Sep-30, Volume: 265, Issue:5181

    Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Electric Stimulation; Enkephalins; GABA-B Receptor Antagonists; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Interneurons; Male; N-Methylaspartate; Neural Inhibition; Organophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Theophylline

1994
Antinociception induced by intrathecal coadministration of selective adenosine receptor and selective opioid receptor agonists in mice.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: Adenosine; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Narcotics; Phenethylamines; Receptors, Opioid; Receptors, Purinergic P1

1994
Age-related loss of mRNA encoding adenosine A2 receptor in the rat striatum.
    Neuroscience letters, 1993, Aug-20, Volume: 158, Issue:2

    Topics: Adenosine; Aging; Animals; Autoradiography; Biomarkers; Corpus Striatum; Enkephalins; Histocytochemistry; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Oligonucleotide Probes; Phenethylamines; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger

1993
Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:12

    Topics: Adenosine; Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Rats; Rats, Sprague-Dawley; Xanthines

1995
High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors.
    The Journal of physiology, 1996, Apr-01, Volume: 492 ( Pt 1)

    Topics: Action Potentials; Adenosine; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA Agonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Male; Organophosphorus Compounds; Phosphinic Acids; Potassium Channels; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, GABA

1996
Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes.
    European journal of pharmacology, 1996, Feb-29, Volume: 298, Issue:1

    Topics: Adenosine; Animals; Drug Synergism; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Synaptosomes

1996
Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:1

    Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Arteries; Blood Pressure; Cyclic AMP; Cyclic GMP; Enkephalin, Leucine; Enkephalin, Methionine; Female; Glyburide; Hypoxia; Male; Nitric Oxide; Nucleotides, Cyclic; Pia Mater; Potassium Channels; Swine; Theophylline; Vasodilation; Vasodilator Agents

1997
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jan-15, Volume: 17, Issue:2

    Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Dinoprostone; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Models, Biological; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Receptors, Purinergic P1; Second Messenger Systems; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthines; Yohimbine

1997
Glucocorticoids regulate the expression of adenosine A1 but not A(2A) receptors in rat brain.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenalectomy; Analysis of Variance; Animals; Autoradiography; Brain; Cyclic AMP; Dexamethasone; Enkephalins; Gene Expression; Glucocorticoids; Humans; In Situ Hybridization; Jurkat Cells; Male; Organ Specificity; PC12 Cells; Phenethylamines; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Transcription, Genetic; Tritium; Xanthines

1997
Rescue of locomotor impairment in dopamine D2 receptor-deficient mice by an adenosine A2A receptor antagonist.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-01, Volume: 20, Issue:15

    Topics: Adenosine; Animals; Antihypertensive Agents; Antineoplastic Agents; Enkephalins; Gait; Gene Expression; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Parkinson Disease, Secondary; Phenethylamines; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; RNA, Messenger; Substance P; Tritium

2000
The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-13, Volume: 98, Issue:4

    Topics: Adenosine; Amphetamines; Animals; Caffeine; Catalepsy; Corpus Striatum; Dopamine Antagonists; Enkephalins; Gene Expression; Haloperidol; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Purinergic P1; RNA, Messenger

2001
The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Oct-15, Volume: 22, Issue:20

    Topics: Adenosine; Animals; Behavior, Animal; Binding, Competitive; Body Weight; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dystonia; Enkephalins; Hindlimb; Huntington Disease; In Vitro Techniques; Male; Mitochondria; Motor Activity; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Propionates; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred Lew; Reproducibility of Results; RNA, Messenger; Succinate Dehydrogenase; Synaptic Transmission; Treatment Outcome

2002
Influence of CGS 21680, a selective adenosine A(2A) agonist, on the phencyclidine-induced sensorimotor gating deficit and motor behaviour in rats.
    Psychopharmacology, 2003, Volume: 168, Issue:3

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Catalepsy; Corpus Striatum; Dopamine Agonists; Enkephalins; Hallucinogens; In Situ Hybridization; Lameness, Animal; Male; Motor Activity; Muscle Rigidity; Nucleus Accumbens; Phencyclidine; Phenethylamines; Protein Precursors; Rats; Rats, Wistar; Reflex, Startle; RNA, Messenger; Rotarod Performance Test

2003
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro.
    Neuropharmacology, 2003, Volume: 45, Issue:5

    Topics: Action Potentials; Adenosine; Affinity Labels; Animals; Colforsin; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Enkephalins; Enzyme Inhibitors; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Probenecid; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Substance Withdrawal Syndrome; Sulfonamides; Synaptic Transmission; Thioinosine; Time Factors; Uricosuric Agents; Vasodilator Agents; Xanthines

2003
Stimulation of adenosine receptors selectively activates gene expression in striatal enkephalinergic neurons.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:10

    Topics: Adenosine; Animals; Corpus Striatum; Drug Combinations; Enkephalins; Gene Expression; Immunohistochemistry; In Situ Hybridization; Male; Neurons; Phenethylamines; Protein Precursors; Proto-Oncogene Proteins c-fos; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1

2006
Reversion of levodopa-induced motor fluctuations by the A2A antagonist CSC is associated with an increase in striatal preprodynorphin mRNA expression in 6-OHDA-lesioned rats.
    Synapse (New York, N.Y.), 2006, Jun-01, Volume: 59, Issue:7

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic Agents; Animals; Caffeine; Corpus Striatum; Dynorphins; Dyskinesias; Enkephalins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger

2006
Genetic deletion of GPR52 enhances the locomotor-stimulating effect of an adenosine A
    Brain research, 2017, Sep-01, Volume: 1670

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Basal Ganglia; Corpus Striatum; Dopamine; Enkephalins; Locomotion; Male; Mice; Mice, Knockout; Neurons; Nucleus Accumbens; Random Allocation; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, G-Protein-Coupled

2017