Compounds > enkephalin, leucine

enkephalin, leucine and 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide

enkephalin, leucine has been researched along with 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (44.44)18.2507
2000's6 (33.33)29.6817
2010's4 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alt, A; Banks, M; Bassoni, DL; Budenholzer, LM; Burford, NT; Canals, M; Christopoulos, A; Filizola, M; Gerritz, SW; Han, Y; Herbst, JJ; Livingston, KE; O'Connell, J; Ryan, MR; Shang, Y; Traynor, JR; Wehrman, TS; Zhang, L1
Calderon, SN; De Leon, IA; Knapp, RJ; Landsman, R; Malatynska, E; Nagase, H; Rice, K; Santoro, G; Varga, E; Waite, S1
Loew, GH; Maguire, PA1
Becketts, K; Bilsky, EJ; Calderon, SN; Davis, P; Flippen-Anderson, JL; Horvath, R; Kayakiri, H; Porreca, F; Rice, KC; Rothman, RB; Smith, LE; Xu, H1
Burkey, TH; Hosohata, K; Hosohata, Y; Hruby, VJ; Knapp, RJ; Nagase, H; Porreca, F; Quock, RM; Rice, KC; Roeske, WR; Yamamura, HI; Zhang, X1
Broccardo, M; Improta, G; Tabacco, A1
Maidment, NT; Olive, MF1
Clapp, JF; Kett, A; Kim, H; Olariu, N; Soong, Y; Szeto, HH; Wu, D1
Benjamin, D; Pohorecky, LA; Rice, KC; Skiandos, A; Zhang, X1
Burkey, TH; Hosohata, Y; Hruby, VJ; Kovelowski, CJ; Lai, J; Ossipov, MH; Porreca, F; Rice, KC; Roeske, WR; Sora, I; Uhl, GR; Vanderah, TW; Yamamura, HI; Zhang, X1
Fiore, P; Gannon, RL; Tierno, A1
Allouche, S; Jauzac, P; Lecoq, I; Marie, N1
Befort, K; Décaillot, FM; Filliol, D; Kieffer, BL; Lazarus, LH; Schiller, PW; Schmidhammer, H; Tryoen-Tóth, P1
Herzog, H; Loacker, S; Sayyah, M; Schwarzer, C; Wittmann, W1
Bolte, C; Newman, G; Schultz, Jel J1
Duarte, ID; Pacheco, CM; Pacheco, Dda F1
Brissett, DI; DeFriel, JN; Harvey, JH; van Rijn, RM; Whistler, JL1
Chandra, R; Cheer, JF; Dias, C; Francis, TC; Lobo, MK; Nam, H1

Other Studies

18 other study(ies) available for enkephalin, leucine and 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide

ArticleYear
Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.
    Journal of medicinal chemistry, 2015, May-28, Volume: 58, Issue:10

    Topics: Animals; Arrestins; Benzamides; beta-Arrestins; Binding, Competitive; Cell Membrane; Chemistry Techniques, Synthetic; CHO Cells; Cricetulus; Drug Discovery; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Molecular Structure; Molecular Targeted Therapy; Piperazines; Protein Binding; Quinolines; Receptors, Opioid, delta; Structure-Activity Relationship

2015
Efficacy of peptide and nonpeptidic agonists at the cloned human delta opioid receptor.
    Proceedings of the Western Pharmacology Society, 1995, Volume: 38

    Topics: Analgesics; Animals; Benzamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Opioid Peptides; Piperazines; Quinolines; Receptors, Opioid, delta; Recombinant Proteins

1995
Thermodynamics of ligand binding to the cloned delta-opioid receptor.
    European journal of pharmacology, 1996, Dec-30, Volume: 318, Issue:2-3

    Topics: Animals; Benzamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Oligopeptides; Piperazines; Receptors, Opioid, delta; Recombinant Proteins; Thermodynamics

1996
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80)
    Journal of medicinal chemistry, 1997, Feb-28, Volume: 40, Issue:5

    Topics: Animals; Benzamides; Binding, Competitive; Brain; Crystallography, X-Ray; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Molecular Structure; Muscle Contraction; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Vas Deferens

1997
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.
    European journal of pharmacology, 1997, May-12, Volume: 326, Issue:1

    Topics: Animals; Benzamides; CHO Cells; Cloning, Molecular; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naltrexone; Narcotic Antagonists; Piperazines; Quinolines; Receptors, Opioid, delta; Sulfur Radioisotopes

1997
Central effect of SNC 80, a selective and systemically active delta-opioid receptor agonist, on gastrointestinal propulsion in the mouse.
    European journal of pharmacology, 1998, Jan-26, Volume: 342, Issue:2-3

    Topics: Animals; Benzamides; Central Nervous System; Colon; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Injections, Intraperitoneal; Male; Mice; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, sigma

1998
Opioid regulation of pallidal enkephalin release: bimodal effects of locally administered mu and delta opioid agonists in freely moving rats.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzamides; Dose-Response Relationship, Drug; Enkephalins; Globus Pallidus; Male; Morphine; Morphine Derivatives; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1998
Respiratory depression after intravenous administration of delta-selective opioid peptide analogs.
    Peptides, 1999, Volume: 20, Issue:1

    Topics: Analgesics; Animals; Benzamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Piperazines; Pregnancy; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Physiological Phenomena; Sheep

1999
Effect of chronic social stress on delta-opioid receptor function in the rat.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1

    Topics: Adrenal Glands; Agonistic Behavior; Analgesia; Animals; Benzamides; Body Temperature; Body Weight; Brain; Catecholamines; Chronic Disease; Corticosterone; Defecation; Dominance-Subordination; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Motor Activity; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Social Environment; Stress, Psychological

1999
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
    European journal of pharmacology, 2000, Feb-04, Volume: 388, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membranes; Mice; Mice, Knockout; Oligopeptides; Pain Measurement; Piperazines; Protein Binding; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord

2000
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
    Brain research, 2002, May-24, Volume: 937, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus

2002
Different regulation of human delta-opioid receptors by SNC-80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and endogenous enkephalins.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:2

    Topics: Benzamides; Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; Enkephalins; Humans; Piperazines; Protein Binding; Receptors, Opioid, delta

2004
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Alkaline Phosphatase; Benzamides; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mutation; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Structure-Activity Relationship

2005
Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.
    Brain : a journal of neurology, 2007, Volume: 130, Issue:Pt 4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzamides; Cell Count; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Temporal Lobe; Guanidines; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Nerve Degeneration; Piperazines; Protein Precursors; Receptors, Opioid, kappa; Synaptic Transmission; Time Factors

2007
Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzamides; beta-Endorphin; Blood Pressure; Cricetinae; Cyclic AMP; Disease Models, Animal; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Hypertension; Hypertrophy, Left Ventricular; Myocardial Contraction; Myocardium; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Systole; Ventricular Remodeling

2009
δ-Opioid receptor agonist SNC80 induces central antinociception mediated by Ca2+ -activated Cl- channels.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:8

    Topics: Analgesics, Opioid; Animals; Benzamides; Benzomorphans; Calcium; Cations; Chloride Channels; Enkephalins; Hot Temperature; Male; Mice; Mice, Inbred Strains; Niflumic Acid; Pain; Pain Threshold; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2012
Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1

    Topics: Amino Acid Sequence; Benzamides; Calcium; Calcium Signaling; Cloning, Molecular; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enzyme-Linked Immunosorbent Assay; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; HEK293 Cells; Humans; Microscopy, Fluorescence; Molecular Sequence Data; Mutant Chimeric Proteins; Piperazines; Polymerase Chain Reaction; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Recombinant Fusion Proteins; Signal Transduction

2013
Reduced nucleus accumbens enkephalins underlie vulnerability to social defeat stress.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019, Volume: 44, Issue:11

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzamides; Depression; Disease Models, Animal; Dominance-Subordination; Enkephalins; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Piperazines; Receptors, Opioid, delta; Stress, Psychological

2019