enkephalin--leucine-2-alanine and hydroxyethylcellulose

The results of the development of combined eye gel with interferon alpha-2-beta are presented. Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated. The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.

Topics: Cellulose; Drug Delivery Systems; Enkephalin, Leucine-2-Alanine; Gels; Interferon alpha-2; Viscosity