Compounds > enkephalin--leucine-2-alanine

enkephalin--leucine-2-alanine and formic-acid

enkephalin--leucine-2-alanine has been researched along with formic-acid* in 1 studies

Other Studies

1 other study(ies) available for enkephalin--leucine-2-alanine and formic-acid

Article	Year
Applications of ammonium formate-catalytic transfer hydrogenation. Part V (1). Transfer hydrogenolysis of peptides containing p-chlorophenylalanine as a convenient method for preparation of deuterium labeled peptides. International journal of peptide and protein research, 1987, Volume: 30, Issue:4 Dehalogenation of chlorine bound to aromatic nuclei has been achieved using ammonium formate-catalytic transfer hydrogenation (AF-CTH) techniques. The use of deuterated ammonium formate as the transfer agent in the CTH process when performed in a deuterated solvent medium results in the predominant formation of the labeled product. Thus, ND+4 DCOO(-)-CTH of [D-Ala2, p-ClPhe4]-Leu-enkephalin in 80% CD3COOD/D2O yielded [D-Ala2, Phe (4D)4]-Leu-enkephalin. Levels of D-incorporation were measured by fast atom bombardment-mass spectrometry (FAB-MS) and/or by 13C n.m.r. spectroscopy. Using D-labeled and unlabeled ammonium formate in stoichiometrically similar reactions, it was concluded that the hydrogenation exhibited a primary kinetic isotope effect. Reactant and product concentrations were determined by amino acid analysis and reversed phase HPLC. Topics: Deuterium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fenclonine; Formates; Hydrogenation; Indicators and Reagents; Isotope Labeling; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oligopeptides	1987

Article

Year

Applications of ammonium formate-catalytic transfer hydrogenation. Part V (1). Transfer hydrogenolysis of peptides containing p-chlorophenylalanine as a convenient method for preparation of deuterium labeled peptides.

International journal of peptide and protein research, 1987, Volume: 30, Issue:4

Dehalogenation of chlorine bound to aromatic nuclei has been achieved using ammonium formate-catalytic transfer hydrogenation (AF-CTH) techniques. The use of deuterated ammonium formate as the transfer agent in the CTH process when performed in a deuterated solvent medium results in the predominant formation of the labeled product. Thus, ND+4 DCOO(-)-CTH of [D-Ala2, p-ClPhe4]-Leu-enkephalin in 80% CD3COOD/D2O yielded [D-Ala2, Phe (4D)4]-Leu-enkephalin. Levels of D-incorporation were measured by fast atom bombardment-mass spectrometry (FAB-MS) and/or by 13C n.m.r. spectroscopy. Using D-labeled and unlabeled ammonium formate in stoichiometrically similar reactions, it was concluded that the hydrogenation exhibited a primary kinetic isotope effect. Reactant and product concentrations were determined by amino acid analysis and reversed phase HPLC.

Topics: Deuterium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fenclonine; Formates; Hydrogenation; Indicators and Reagents; Isotope Labeling; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oligopeptides

1987