enkephalin--leucine-2-alanine and bismuth-tripotassium-dicitrate

Having a large clinical material at their disposal, the authors base the necessity of the search and administration of more effective methods of duodenal ulcer treatment. Analyze the therapeutic effect produced by the enkephalin analogs (dalargin and its combinations with trichopol, de-nol, oxacillin) in connection with infection with Campylobacter . Comparison of the clinico-endoscopic data with the histological and cytological findings enabled arriving at a conclusion about the pathogenetic effect of the antimicrobial drugs. As a rule, the healing of ulcerous defects set in on days 11-14 of the treatment.

Topics: Adolescent; Aluminum Hydroxide; Antacids; Benzocaine; Child; Drug Combinations; Duodenal Ulcer; Enkephalin, Leucine-2-Alanine; Female; Humans; Magnesium Hydroxide; Male; Organometallic Compounds; Wound Healing

A study of 90 patients with endoscopically proved duodenal ulcer revealed that dalargin and trichopol+dalargin treatment resulted in early scarring of the ulcer and control of gastroesophageal and duodenogastric reflux in the majority of patients. Gastroduodenitis symptoms were not eliminated in a half of all patients. It was shown that persistent manifestations of gastroduodenitis remained in patients with a pronounced pyloric helicobacteriosis and a high titer of antibodies to cells of the gastric mucosa.

Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Evaluation; Drug Therapy, Combination; Duodenal Ulcer; Enkephalin, Leucine-2-Alanine; Female; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Organometallic Compounds