enkephalin, d-penicillamine (2,5)- has been researched along with naloxone in 197 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (20.81) | 18.7374 |
| 1990's | 112 (56.85) | 18.2507 |
| 2000's | 34 (17.26) | 29.6817 |
| 2010's | 8 (4.06) | 24.3611 |
| 2020's | 2 (1.02) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Bihel, F; Drieu la Rochelle, A; Elhabazi, K; Gizzi, P; Henningsen, JB; Ilien, B; Kugler, V; Quillet, R; Schmitt, M; Schneider, S; Simonin, F; Simonneaux, V; Utard, V | 1 |
| Gintzler, AR; Xu, H | 2 |
| Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L | 1 |
| Madamba, S; Siggins, GR; Yuan, XR | 1 |
| Green, PG; Levine, JD | 1 |
| Crook, TJ; Hill, RG; Kitchen, I | 1 |
| Chaki, K; Kisara, K; Nakata, N; Sakurada, S; Sakurada, T; Suzuki, K; Watanabe, H | 1 |
| Mosberg, HI; Porreca, F; Raffa, RB; Wild, KD | 1 |
| Edwards, RH; Evans, CJ; Keith, DE; Magendzo, K; Morrison, H | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N | 1 |
| Han, JS; Ren, MF; Sun, XJ; Wang, JF; Yang, HF | 1 |
| Gulya, K; Kása, P; Kovács, GL | 1 |
| Drukarch, B; Mulder, AH; Ruuls, SR; Schoffelmeer, AN; Van Vliet, BJ | 1 |
| Matsuyama, S; Nakayama, S; Sano, I; Takeda, K; Tanaka, C; Taniyama, K; Yoshihara, C | 1 |
| Gratton, A; Pentney, RJ | 1 |
| Hattori, Y; Katafuchi, T; Koizumi, K | 1 |
| Jones, AJ; Keen, P; Ray, NJ | 1 |
| Burks, TF; Davis, TP; Greene, DL; Hersh, LB; Hruby, VJ; Kramer, TH; Sharma, SD; Weber, SJ; Yamamura, HI | 1 |
| Butt, W; Cowan, A; Fisher, RS; Krevsky, B; Maurer, AH | 1 |
| Collins, JG; Kitahata, LM; Nakagawa, I; Nakatani, K; Omote, K | 1 |
| Giuliani, S; Maggi, CA; Meli, A | 1 |
| Alberch, J; Arenas, E; Marsal, J; Sanchez Arroyos, R | 1 |
| Burks, TF; Lemcke, PK; Shook, JE | 1 |
| Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN | 1 |
| Henry, JL; Rochford, J | 1 |
| Hill, RG; Hughes, J; Hunter, JC; Rodriguez, RE; Traynor, JR | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Hahn, EF; Howard, DH; Levison, JA; Pasternak, GW; Paul, D; Pick, CG | 1 |
| Fan, LQ; Hiller, JM; Simon, EJ | 1 |
| Duan, SM; Fukuda, A; Hori, T; Oomura, Y; Shimizu, N | 1 |
| Cowan, A; Murray, CW | 1 |
| Burks, TF; Hruby, VJ; Spencer, RL | 2 |
| Kavaliers, M | 1 |
| Herz, A; Millan, MJ; Peter, K; Shippenberg, TS; Stein, C | 1 |
| Alvarado, MC; Bennett, EL; Hruby, VJ; Martinez, JL; Patterson, TA; Rosenzweig, MR; Schulteis, G | 1 |
| Di Chiara, G; Fenu, S; Morelli, M | 1 |
| Bueno, L; Gué, M; Junien, JL | 1 |
| Kiritsy-Roy, JA; Marson, L; Van Loon, GR | 2 |
| Hong, EK; Takemori, AE | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 1 |
| Bodnar, RJ; Gistrak, MA; Pasternak, GW; Paul, D | 1 |
| Dashwood, MR; Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Crisp, T; Spanos, LJ; Stafinsky, JL | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Gintzler, AR; Smolens, I; Xu, H | 1 |
| Brown, SR; Cox, BM; Werling, LL | 1 |
| La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 1 |
| Mathiasen, JR; Raffa, RB; Vaught, JL | 1 |
| Burks, TF; Heyman, JS; Mosberg, HI; Porreca, F; Williams, CL | 1 |
| Brinsfield, KH; Matsumoto, RR; Patrick, RL; Walker, JM | 1 |
| Dashwood, MR; Muddle, JR; Spyer, KM | 1 |
| Gulya, K; Hruby, VJ; Pelton, JT; Yamamura, HI | 1 |
| Burks, TF; Deupree, D; Hruby, V; Hsiao, S; Mosberg, HI; Porreca, F; Spencer, RL | 1 |
| Kastin, AJ; Zadina, JE | 1 |
| Burks, TF; Hruby, VJ; Lemcke, PK; Pelton, JT; Porreca, F; Shook, JE | 1 |
| Gulya, K; Hruby, VJ; Kazmierski, W; Lui, GK; Pelton, JT; Yamamura, HI | 1 |
| Chavkin, C; Mailheau, S; Neumaier, JF | 1 |
| Clark, JA; Houghten, R; Pasternak, GW | 1 |
| Fujiwara, M; Kurahashi, K; Okamoto, T | 1 |
| Dray, A; Nunan, L; Wire, W | 2 |
| Hansen, HA; Mulder, AH; Schoffelmeer, AN; Stoof, JC | 1 |
| Heyman, JS; Koslo, RJ; Mosberg, HI; Porreca, F; Tallarida, RJ | 1 |
| Chang, KJ; Leslie, JB; Russell, RD; Su, YF; Watkins, WD | 1 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Duffy, P; Kalivas, PW; Latimer, LG | 1 |
| Gardner, EL; Vaysse, PJ; Zukin, RS | 1 |
| Bozarth, M; Jenck, F; Wise, RA | 1 |
| Dray, A; Nunan, L | 1 |
| Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Laorden, ML; Llobell, F | 1 |
| Gulya, K; Kása, P; Szikra, J | 1 |
| Chiappinelli, VA; Feng, C; McMahon, LL; Wolf, KM; Yum, L | 1 |
| Capasso, A; Carnuccio, R; D'Acquisto, F; Iuvone, T | 1 |
| Ableitner, A; Hassan, AH; Herz, A; Stein, C | 1 |
| Klitenick, MA; Wirtshafter, D | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Evans, CJ; Hales, TG; Law, PY; Loh, HH; Piros, ET; Prather, PL | 1 |
| Adams, JU; Li, S; Liu-Chen, LY; Yang, HH | 1 |
| Glick, SD; Herrick-Davis, K; Pearl, SM; Teitler, M | 1 |
| Bidlack, JM; Chung, NN; Dooley, CT; Houghten, RA; Pasternak, GW; Schiller, PW; Wilkes, BC | 1 |
| Ichikawa, T; Ikeda, K; Kobayashi, T; Kumanishi, T; Usui, H | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Madamba, SG; Moore, SD; Schweitzer, P; Siggins, GR | 1 |
| North, RA; Tanaka, E | 1 |
| Garzón, J; Martínez-Peña, Y; Sánchez-Blázquez, P | 1 |
| Jauzac, P; Polastron, J | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Laorden, ML; Micol, JA | 1 |
| Coenen, A; Lasoń, W; Przewłocka, B; Przewłocki, R; Van Luijtelaar, G | 1 |
| Garty, M; Keren, O; Sarne, Y | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| North, RA; Sugita, S | 1 |
| Adamo, EB; Di Giovanni, G; Marini, R; Mulè, F; Postorino, A; Serio, R | 1 |
| Jin, W; Lee, NM; Loh, HH; Thayer, SA | 1 |
| Higuchi, H; Kuo, CH; Miki, N; Nakano, K; Osugi, T | 1 |
| Hasegawa, A; Nagamatsu, K; Tagawa, Y; Uchida, S | 1 |
| Aloyo, VJ; Battisi, WP; Pazdalski, PS | 1 |
| Parenti, C; Scoto, GM | 1 |
| Welch, SP | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Fan, LQ; Gioannini, TL; Hiller, JM; Hyde, L; Ofri, D; Simon, EJ; Yao, YH | 1 |
| Cheng, PY; Decena, JA; McCabe, S; Soong, Y; Szeto, HH; Wu, D | 1 |
| Aloyo, VJ; Harvey, JA; Romano, AG | 1 |
| Goñalons, E; Jiménez, M; Martínez, V; Vergara, P | 1 |
| Chaplan, SR; Lee, YW; Yaksh, TL | 1 |
| Endoh, T; Suzuki, T | 2 |
| Ludbrook, J; Ventura, S | 1 |
| Potter, DE; Wang, D | 1 |
| Bailey, EC; Bruce, DS; Hellgren, EC; Horton, ND; Jacobson, D; Oeltgen, PR; Setran, DP; Tramell, MS | 1 |
| Honkanen, A; Hyytiä, P; Korpi, ER; Sarviharju, M; Vilamo, L; Wegelius, K | 1 |
| Cox, BM; Noble, F | 1 |
| Casares, F; Liu, U; Stefano, GB | 1 |
| Audet, RM; Butterworth, RF; de Waele, JP; Leong, DK | 1 |
| Mokha, SS; Wang, XM | 1 |
| Kaputlu, I; Oğütman, C; Sadan, G | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM | 1 |
| Mokha, SS; Wang, XM; Yan, JQ; Zhang, KM | 1 |
| Peter, Y; Pick, CG; Schreiber, S; Weizman, R | 1 |
| Bodnar, RJ; Ruegg, H; Yu, WZ | 1 |
| Khan, S; Smith, ME | 1 |
| Kuraishi, Y; Tohda, C; Yamaguchi, T | 1 |
| Kavaliers, M; Ossenkopp, KP; Prato, FS; Thomas, AW | 1 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Kramer, TH; Porreca, F | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Herlenius, EA; Lindahl, SG; Takita, K; Yamamoto, Y | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Hauser, KF; Stiene-Martin, A; Zhou, R | 1 |
| Carney, JM; Harris-White, ME; Hauser, KF; Jackson, JA; Opanashuk, LA | 1 |
| Carabelli, V; Carbone, E; Carra, I | 1 |
| Carbone, E; Clementi, F; Codignola, A; Missale, C; Sher, E; Spano, P | 1 |
| Fukuda, K; Kato, S; Mima, H; Mori, K; Morikawa, H; Shoda, T | 1 |
| Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G | 1 |
| Gilmore, DP; Wilson, CA; Yilmaz, B | 1 |
| Finberg, RW; Heagy, W; Lopez, P; Teng, E | 1 |
| Fujimoto, JM; Gorny, JM; Rady, JJ | 1 |
| Joshi, S; Lee, JW; Wong, YH | 1 |
| Fuchs, PN; Raja, SN; Roza, C; Sora, I; Uhl, G | 1 |
| Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T | 1 |
| Környei, JL; Kovács, KA; Oszter, A; Rao, CV; Vértes, M; Vértes, Z | 1 |
| Allouche, S; Jauzac, P; Marie, N; Roussel, M | 1 |
| Babey, AM; Cavalli, A; Loh, HH | 1 |
| Brown, DR; Poonyachoti, S | 1 |
| Chen, WY; Hu, Q; Huang, FS; Shi, Y; Tang, Y; Wu, Y | 1 |
| Bilecki, W; Höllt, V; Przewłocki, R | 1 |
| Elde, RP; Hauser, KF; Houdi, AA; Maxson, W; Turbek, CS | 1 |
| Endo, K; Yawo, H | 1 |
| Charles, RC; Evans, CJ; Hales, TG; Piros, ET; Song, L | 1 |
| Fan, T; George, SR; O'Dowd, BF; Tam, V; Tse, R; Varghese, G; Xie, Z | 1 |
| Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS | 1 |
| Singh, PP; Singh, S | 1 |
| Akil, H; Bonner, G; Meng, F | 1 |
| Calvo, CF; Cesselin, F; Gelman, M; Glowinski, J | 1 |
| Chen, ZW; Han, JS; Wang, Y; Yang, K | 1 |
| Cho, KP; Kim, KW; Shin, BS; Son, Y | 1 |
| Baldelli, P; Carabelli, V; Carbone, E; Hernández-Guijo, JM | 1 |
| Bekkers, JM; Chieng, B | 1 |
| Bradshaw, S; Chang, AH; King, MA; Pasternak, GW; Pintar, JE | 1 |
| Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB | 1 |
| Imai, S; Itou, Y; Narita, M; Suzuki, T; Yajima, Y | 1 |
| Liu, JG; Prather, PL | 1 |
| Irvine, RJ; Lewanowitsch, T | 1 |
| Gross, GJ; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stefano, GB; Tam, SW | 1 |
| Li, J; Li, QX; Qi, JJ; Ye, CY; Yu, XL; Zhang, DC | 1 |
| Choi, DH; Jung, EB; Kim, MS; Kim, TY; Lee, J; Moon, SK; Park, C; Park, R | 1 |
| McCarthy, LE; Nitsche, JF; Pintar, JE; Rogers, TJ | 1 |
| Chuchuen, U; Ebadi, M; Govitrapong, P | 1 |
| Aono, Y; Cools, AR; Fusa, K; Ikeda, H; Koshikawa, N; Nagase, H; Saigusa, T; Suzuki, T; Takahashi, I; Watanabe, S | 1 |
| Ajjimaporn, A; Ebadi, M; Govitrapong, P; Ho, B; Klongpanichapak, S; Sawlom, S; Shavali, S | 1 |
| Codeluppi, S; Hua, XY; Kondo, I; Marvizon, JC; Salgado, F; Song, B; Yaksh, TL | 1 |
| Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K | 1 |
| Baugh, MM; Bradford, CS; Moore, FL; Stanley, DJ; Walthers, EA | 1 |
| Law, PY; Loh, HH; Tetrault, J; Wang, W; Zhang, L | 1 |
| Chen, C; Chong, PL; Huang, P; Liu-Chen, LY; Xu, W; Yoon, SI | 1 |
| Johnson, SM; Kinney, ME; Wiegel, LM | 1 |
| Juma, F; Kanui, TI; Maloiy, GM; Olongida Ole Miaron, J; Towett, PK | 1 |
| Daniel, AM; Ortega, LA; Papini, MR | 1 |
| Sugimoto, Y; Yamamoto, A | 1 |
| Salari, AA; Solati, J; Zarrindast, MR | 1 |
| Traynor, JR; Wang, Q | 1 |
| Holloway, AC; Nurse, CA; Salman, S | 1 |
| Arida, RM; Brand, S; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Rocha, L; Zavala-Tecuapetla, C | 1 |
| Griggs, NW; Harland, AA; Mosberg, HI; Pogozheva, ID; Trask, TJ; Traynor, JR | 1 |
| Jullié, D; Laeremans, T; Lobingier, BT; Manglik, A; Schiller, PW; Steyaert, J; Stoeber, M; von Zastrow, M | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
| Bartoszek, A; Binienda, A; Dziedziczak, K; Fabisiak, A; Fichna, J; Kordek, R; Krajewska, JB; Makaro, A; Mosińska, P; Niewinna, K; Salaga, M; Świerczyński, M; Talar, M; Tarasiuk, A | 1 |
197 other study(ies) available for enkephalin, d-penicillamine (2,5)- and naloxone
| Article | Year |
|---|---|
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Identification of an
Topics: Analgesics, Opioid; Animals; Cricetinae; Dipeptides; Female; Fentanyl; Half-Life; Humans; Hyperalgesia; Luteinizing Hormone; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Protein Isoforms; Receptors, Neuropeptide; Receptors, Opioid; Structure-Activity Relationship | 2021 |
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil | 1992 |
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach | 1992 |
Opioid peptides reduce synaptic transmission in the nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Naloxone; Neurons; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synapses; Synaptic Transmission | 1992 |
Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Bradykinin; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Joints; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
Antinociceptive mechanisms of [D-Arg2]-dermorphin tripeptide analogs.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Mice; Molecular Sequence Data; Naloxone; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu; Synaptosomes | 1992 |
Thermodynamic analysis of the temperature dependence of the dissociation constant of naloxone at opioid delta receptors in the mouse isolated vas deferens.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Receptors, Opioid, delta; Temperature; Thermodynamics; Vas Deferens | 1992 |
Cloning of a delta opioid receptor by functional expression.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Blotting, Southern; Cell Line; Cyclic AMP; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Gene Expression; Humans; Kinetics; Models, Structural; Molecular Sequence Data; Naloxone; Narcotics; Protein Structure, Secondary; Receptors, Opioid, delta; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured | 1992 |
Paradoxical analgesia produced by naloxone in diabetic mice is attributable to supersensitivity of delta-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Pain; Pain Measurement; Pyrrolidines; Reaction Time; Time Factors | 1992 |
Mobilization of calcium from intracellular store as a possible mechanism underlying the anti-opioid effect of angiotensin II.
Topics: Angiotensin II; Calcium; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Neuroblastoma; Potassium Chloride; Saralasin; Tumor Cells, Cultured | 1992 |
Regulation of endogenous calcium and magnesium levels by delta opioid receptors in the rat brain.
Topics: Analgesics; Animals; Brain Chemistry; Calcium; Cations, Divalent; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Magnesium; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spectrophotometry, Atomic | 1991 |
Beta-adrenoceptor-sensitive adenylate cyclase is inhibited by activation of mu-opioid receptors in rat striatal neurons.
Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoproterenol; Male; Naloxone; Neuroglia; Neurons; Norepinephrine; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Norepinephrine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Trimebutine | 1991 |
Effects of local delta and mu opioid receptor activation on basal and stimulated dopamine release in striatum and nucleus accumbens of rat: an in vivo electrochemical study.
Topics: Action Potentials; Animals; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Nucleus Accumbens; Potassium; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Characterization of opioid-sensitive neurons in the anteroventral third ventricle region of polydipsic inbred mice in vitro.
Topics: Angiotensin II; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Drinking Behavior; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypothalamus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Neurons; Peptide Fragments; Species Specificity | 1991 |
Opioids can produce a concentration-dependent naloxone-reversible enhancement of inhibition of evoked enkephalin release.
Topics: Analgesics; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Naloxone; Narcotics; Parasympatholytics; Sufentanil; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Morphine, but not sodium cromoglycate, modulates the release of substance P from capsaicin-sensitive neurones in the rat trachea in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Bradykinin; Capsaicin; Cromolyn Sodium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Neurons; Potassium Chloride; Pyrrolidines; Rats; Rats, Inbred Strains; Substance P; Trachea | 1991 |
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
Topics: Analgesics; Animals; Binding, Competitive; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Neprilysin; Tissue Distribution; Tritium | 1991 |
Effects of selective opioid agonists on feline colonic transit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cattle; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Loperamide; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
The antinociceptive role of mu- and delta-opiate receptors and their interactions in the spinal dorsal horn of cats.
Topics: Analgesics, Opioid; Animals; Cats; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ganglia, Spinal; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Neurons, Afferent; Oligopeptides; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Reserpine | 1990 |
Effect of opioids on acetylcholine release evoked by K+ or glutamic acid from rat neostriatal slices.
Topics: Acetylcholine; Animals; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamates; Glutamic Acid; In Vitro Techniques; Luminescent Measurements; Male; Morphine; Naloxone; Narcotics; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1990 |
Spinally mediated opioid antidiarrheal effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidiarrheals; Body Weight; Diarrhea; Dinoprostone; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Pyrrolidines; Spinal Cord | 1991 |
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses.
Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1990 |
Intrathecal administration of delta receptor agonists in the urethane anesthetized rat provokes an increase in arterial pressure via a non-opioid mechanism.
Topics: Anesthesia; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Injections, Spinal; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord; Urethane | 1990 |
Delta-opioid receptor binding sites in rodent spinal cord.
Topics: Analgesics; Animals; Autoradiography; Binding, Competitive; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Injections, Spinal; Male; Mesocricetus; Mice; Mice, Inbred Strains; Naloxone; Psychomotor Performance; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
Naloxone benzoylhydrazone (NalBzoH) analgesia.
Topics: Analgesia; Analgesics; Animals; Azocines; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Differential effects of cyanogen bromide on ligand binding by mu, delta and kappa opioid receptors.
Topics: Animals; Brain; Cell Membrane; Cyanogen Bromide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ligands; Male; Methionine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Hyperpolarizing action of enkephalin on neurons in the dorsal motor nucleus of the vagus, in vitro.
Topics: Action Potentials; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Medulla Oblongata; Membrane Potentials; Naloxone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vagus Nerve | 1990 |
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior | 1990 |
Alteration of thermoregulatory set point with opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature Regulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains | 1990 |
Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Diltiazem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immobilization; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Nifedipine; Pain; Reaction Time; Stress, Physiological; Verapamil | 1987 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds | 1989 |
Influence of opioid peptides on learning and memory processes in the chick.
Topics: Animals; Attention; beta-Endorphin; Brain Mapping; Chickens; Discrimination Learning; Dominance, Cerebral; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Memory; Mental Recall; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Visual Cortex | 1989 |
Substantia nigra as a site of origin of dopamine-dependent motor syndromes induced by stimulation of mu and delta opioid receptors.
Topics: Animals; Dopamine; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Substantia Nigra | 1989 |
Central and peripheral opioid modulation of gastric relaxation induced by feeding in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Dogs; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Morphine; Muscle Relaxation; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagotomy; Vagus Nerve | 1989 |
mu-Opioid peptide modulation of cardiovascular and sympathoadrenal responses to stress.
Topics: Animals; Blood Pressure; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Restraint, Physical; Stress, Psychological; Time Factors | 1989 |
Indirect involvement of delta opioid receptors in cholecystokinin octapeptide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Sincalide | 1989 |
Multi-dimensional analysis of behavior in mice treated with the delta opioid agonists DADL (D-Ala2-D-Leu5-enkephalin) and DPLPE (D-Pen2-L-Pen5-enkephalin).
Topics: Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Different mu receptor subtypes mediate spinal and supraspinal analgesia in mice.
Topics: Analgesia; Anesthesia, Spinal; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution.
Topics: Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Blood Glucose; Brain Chemistry; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Injections, Intraventricular; Medulla Oblongata; Naloxone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Respiration | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Sympathoadrenal, cardiovascular and blood gas responses to highly selective mu and delta opioid peptides.
Topics: Animals; Blood Pressure; Carbon Dioxide; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Male; Naloxone; Oxygen; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.
Topics: Anesthetics; Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.
Topics: Action Potentials; Animals; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Myenteric Plexus; Naloxone; Sufentanil | 1989 |
Opioid receptor regulation of the release of norepinephrine in brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Models, Neurological; Naloxone; Norepinephrine; Potassium; Pyrrolidines; Receptors, Opioid | 1987 |
The role of mu- and delta- opioid receptors on the intestinal propulsion in rats.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Gastrointestinal Transit; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse.
Topics: Analgesia; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Species Specificity | 1988 |
Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: studies with naloxonazine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Rotational behavior mediated by dopaminergic and nondopaminergic mechanisms after intranigral microinjection of specific mu, delta and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydroxydopamines; Male; Microinjections; Motor Activity; Naloxone; Narcotics; Oxidopamine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rotation | 1988 |
Body temperature response profiles for selective mu, delta and kappa opioid agonists in restrained and unrestrained rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical | 1988 |
Opiate receptor subtypes in the nucleus tractus solitarii of the cat: the effect of vagal section.
Topics: Animals; Autoradiography; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Female; Male; Medulla Oblongata; Naloxone; Receptors, Opioid; Vagotomy | 1988 |
Cyclic somatostatin octapeptide analogues with high affinity and selectivity toward mu opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, Somatostatin; Somatostatin; Structure-Activity Relationship | 1986 |
Centrally-administered opioid selective agonists inhibit drinking in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Drinking Behavior; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid | 1986 |
Interactions of Tyr-MIF-1 at opiate receptor sites.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Mu opioid antagonist properties of a cyclic somatostatin octapeptide in vivo: identification of mu receptor-related functions.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred ICR; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1987 |
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2: a potent and selective antagonist opioid receptors.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1986 |
Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GABA Antagonists; Hippocampus; Interneurons; Naloxone; Oligopeptides; Rats; Receptors, Opioid | 1988 |
Opiate binding in calf thalamic membranes: a selective mu 1 binding assay.
Topics: Animals; Cattle; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus | 1988 |
Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats.
Topics: Animals; Cats; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Narcotic Antagonists; Narcotics; Peptide Fragments; Stomach; Vagus Nerve | 1988 |
Proenkephalin A fragments exhibit spinal and supraspinal opioid activity in vivo.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Muscle Contraction; Naloxone; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Urinary Bladder | 1985 |
Blockade of D-2 dopamine receptors strongly enhances the potency of enkephalins to inhibit dopamine-sensitive adenylate cyclase in rat neostriatum: involvement of delta- and mu-opioid receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclase Inhibitors; Animals; Benzazepines; Corpus Striatum; Cyclic AMP; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ergolines; Male; Morphine; Naloxone; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: studies with receptor selective agonists.
Topics: Analgesia; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Spinal Cord | 1986 |
Continuous intrathecal opioid analgesia: tolerance and cross-tolerance of mu and delta spinal opioid receptors.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1987 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Naloxonazine and opioid-induced inhibition of reflex urinary bladder contractions.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Muscle Contraction; Naloxone; Rats; Receptors, Opioid; Reflex; Urinary Bladder | 1987 |
Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Motor Activity; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tegmentum Mesencephali | 1987 |
Modulation of rat brain opioid receptors by cannabinoids.
Topics: Animals; Cannabinoids; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spiperone | 1987 |
Contraversive circling induced by ventral tegmental microinjections of moderate doses of morphine and [D-Pen2, D-Pen5]enkephalin.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Morphine; Naloxone; Rats; Stereotyped Behavior; Tegmentum Mesencephali; Time Factors | 1988 |
Evidence that naloxonazine produces prolonged antagonism of central delta opioid receptor activity in vivo.
Topics: Animals; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Naloxone; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1984 |
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isomerism; Kinetics; Muscle Contraction; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1983 |
In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice.
Topics: Amino Acid Sequence; Analgesia; Animals; Antibodies; Benzeneacetamides; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunization, Passive; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
[D-Pen2,D-Pen5]enkephalin, a delta opioid agonist reduces endogenous aluminum content in the rat central nervous system.
Topics: Aluminum; Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Time Factors | 1995 |
Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons.
Topics: Amino Acid Sequence; Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; GTP-Binding Proteins; In Vitro Techniques; Molecular Sequence Data; Naloxone; Nerve Endings; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Reticular Formation; Substance P | 1993 |
Opioids inhibit the induction of nitric oxide synthase in J774 macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Induction; Lipopolysaccharides; Macrophages; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Pyrrolidines; Receptors, Opioid | 1995 |
Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Axonal Transport; beta-Endorphin; Biological Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Ligation; Male; Naloxone; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve | 1993 |
Behavioral and neurochemical effects of opioids in the paramedian midbrain tegmentum including the median raphe nucleus and ventral tegmental area.
Topics: Animals; Brain Chemistry; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Male; Morphine; Motor Activity; Naloxone; Neurotransmitter Agents; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Tegmental Area | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Barium; Calcium Channels; Cell Line; Cloning, Molecular; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Transport; Membrane Potentials; Morphine; Naloxone; Pertussis Toxin; Pituitary Gland; Rats; Receptors, Opioid, mu; Somatostatin; Transfection; Virulence Factors, Bordetella | 1995 |
Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium | 1995 |
Radioligand-binding study of noribogaine, a likely metabolite of ibogaine.
Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; In Vitro Techniques; Kinetics; Naloxone; Pyrrolidines; Radioligand Assay; Receptors, Opioid | 1995 |
An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Injections, Intraventricular; Male; Mice; Models, Molecular; Molecular Sequence Data; Naloxone; Opioid Peptides; Pain Measurement; Protein Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism | 1994 |
Functional couplings of the delta- and the kappa-opioid receptors with the G-protein-activated K+ channel.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Base Sequence; Cloning, Molecular; Codon; DNA Primers; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kinetics; Membrane Potentials; Mice; Molecular Sequence Data; Naloxone; Oocytes; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Xenopus laevis | 1995 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Barium Compounds; Cadmium; Carbachol; Chlorides; Computer Simulation; Dynorphins; Electrophysiology; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Models, Neurological; Naloxone; Narcotics; Neurons; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Opioid actions on rat anterior cingulate cortex neurons in vitro.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glutamates; Glutamic Acid; Gyrus Cinguli; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Neurotransmitter Agents; Rats; Receptors, Opioid; Somatostatin; Synapses; Synaptic Transmission | 1994 |
Dissimilar efficacy of opioids to produce mu-mediated analgesia: role of Gx/z and Gi2 transducer proteins.
Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Cell Membrane; Cerebral Ventricles; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Immunoglobulin G; Injections, Intraventricular; Kinetics; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Pain; Peptide Fragments; Receptors, Opioid, mu; Signal Transduction | 1994 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Effects of mu-, delta- and kappa-agonists on isolated right atria of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Propranolol; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Effects of mu and delta opioid receptor agonists and antagonists on absence epilepsy in WAG/Rij rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epilepsy, Absence; Male; Naloxone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH.
Topics: Cell Line; Dextrorphan; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Levorphanol; Morphine; Naloxone; Narcotics; Neuroblastoma; Norepinephrine; Receptors, Opioid; Tritium; Tumor Cells, Cultured | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Opioid actions on neurons of rat lateral amygdala in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Amino Acids; Amygdala; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; GABA-A Receptor Antagonists; In Vitro Techniques; Molecular Sequence Data; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pyrrolidines; Rats; Somatostatin; Synapses | 1993 |
Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum: role of opiates and 5-hydroxytryptamine.
Topics: Analgesics; Animals; Atropine; Autonomic Nervous System; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Rats; Rats, Wistar; Serotonin; Synaptic Transmission; Tetrodotoxin | 1993 |
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Fura-2; Glioma; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Microscopy, Fluorescence; Naloxone; Narcotics; Neuroblastoma; Pyrrolidines; Rats; Tumor Cells, Cultured | 1994 |
Tyrosine phosphorylation of a 58 kDa protein induced by morphine in SK-N-SH cells.
Topics: Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Kinetics; Molecular Weight; Morphine; Naloxone; Nerve Tissue Proteins; Pertussis Toxin; Phosphorylation; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Tyrosine; Virulence Factors, Bordetella | 1994 |
Mouse brain opioid receptor identification by direct ultraviolet photoaffinity labeling.
Topics: Affinity Labels; Animals; Binding Sites; Dithiothreitol; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Naloxone; Receptors, Opioid; Tritium; Tyrosine; Ultraviolet Rays | 1993 |
Characterization and localization of delta opioid binding sites in the bovine pineal gland.
Topics: Animals; Autoradiography; Binding Sites; Cattle; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Naloxone; Pineal Gland; Receptors, Opioid, delta | 1993 |
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Restraint, Physical; Stomach Ulcer; Stress, Physiological | 1993 |
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
Reconstitution of a purified mu-opioid binding protein in liposomes: selective, high affinity, GTP gamma S-sensitive mu-opioid agonist binding is restored.
Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Cholic Acids; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Liposomes; Morphine; Naloxone; Narcotics; Receptors, Opioid, mu | 1993 |
Role of mu 1- and delta-opioid receptors in modulation of fetal EEG and respiratory activity.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetal Movement; Fetus; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep | 1993 |
Evidence for an involvement of the mu-type of opioid receptor in the modulation of learning.
Topics: Animals; Autoradiography; Blinking; Brain; Cerebral Ventricles; Conditioning, Classical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intraventricular; Learning; Male; Naloxone; Nictitating Membrane; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1993 |
In vivo modulation of gastrointestinal motor activity by Met-enkephalin, morphine and enkephalin analogs in chickens.
Topics: Amino Acid Sequence; Animals; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Immunohistochemistry; Male; Molecular Sequence Data; Morphine; Motor Activity; Naloxone; Nerve Fibers; Vagotomy; Vagus Nerve | 1993 |
Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Peripheral Nerve Injuries; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1995 |
The effects of delta-opioid receptor agonists on synaptic transmission in hamster submandibular ganglion.
Topics: Animals; Autonomic Fibers, Preganglionic; Cricetinae; Dimethylphenylpiperazinium Iodide; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; Ganglionic Stimulants; Naloxone; Narcotic Antagonists; Presynaptic Terminals; Receptors, Opioid, delta; Submandibular Gland; Synaptic Transmission | 1995 |
L-Arginine reverses the abolition of hypovolaemic decompensation by N-nitro-L-arginine methyl ester and naloxone in conscious rabbits.
Topics: Animals; Arginine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Shock, Hemorrhagic | 1995 |
Ocular action of an opioid peptide, DPDPE.
Topics: Administration, Topical; Analgesics; Animals; Ciliary Body; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Intraocular Pressure; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits | 1996 |
Circannual variations in bear plasma albumin and its opioid-like effects on guinea pig ileum.
Topics: Analgesics; Animals; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hibernation; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Seasons; Serum Albumin; Ursidae | 1996 |
Alcohol drinking is reduced by a mu 1- but not by a delta-opioid receptor antagonist in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aminobutyrates; Analgesics; Animals; Brain; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Thalamus | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
Portacaval anastomosis induces region-selective alterations of the endogenous opioid system in the rat brain.
Topics: Alcohol Drinking; Analysis of Variance; Animals; beta-Endorphin; Brain; Brain Chemistry; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Narcotic Antagonists; Pituitary Gland; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of trigeminothalamic neurons.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microelectrodes; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Trigeminal Nuclei | 1996 |
Cardiovascular effects of intrathecally injected mu, delta and kappa opioid receptor agonists in rabbits.
Topics: Animals; Baroreflex; Benzomorphans; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Naloxone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
Role of kappa opioid receptors in modulating cholinergic twitches in the circular muscle of guinea-pig colon.
Topics: Acetylcholine; Animals; Colon; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Cholinergic; Receptors, Opioid, kappa | 1996 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Haloperidol; Humans; Kinetics; Morphine; Naloxone; Neuroblastoma; Pentazocine; Phosphatidylinositols; Receptors, Opioid; Receptors, sigma; Trypsin; Tumor Cells, Cultured | 1996 |
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons; Nociceptors; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus | 1996 |
Pharmacological characterization of buprenorphine, a mixed agonist-antagonist with kappa 3 analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Buprenorphine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sensitivity and Specificity | 1997 |
Delta and kappa opioid receptor subtypes and ingestion: antagonist and glucoprivic effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Ventricles; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperphagia; Infusions, Parenteral; Male; Naloxone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regression Analysis | 1997 |
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Mice; Mice, Inbred C57BL; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neostigmine; Oligopeptides; Peptide Fragments | 1997 |
Intracisternal injection of opioids induces itch-associated response through mu-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cisterna Magna; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Pruritus; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Pulsed magnetic field induced "analgesia" in the land snail, Cepaea nemoralis, and the effects of mu, delta, and kappa opioid receptor agonists/antagonists.
Topics: Analgesia; Animals; Electromagnetic Fields; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Snails | 1997 |
Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Vas Deferens | 1997 |
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum.
Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Actions of opioids on respiratory activity via activation of brainstem mu-, delta- and kappa-receptors; an in vitro study.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Medulla Oblongata; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiratory System | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Animals; Antibody Specificity; Astrocytes; Brain Chemistry; Calcium; Cell Cycle; Cell Division; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Flow Cytometry; Hippocampus; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Opioids disrupt Ca2+ homeostasis and induce carbonyl oxyradical production in mouse astrocytes in vitro: transient increases and adaptation to sustained exposure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Astrocytes; Calcium; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homeostasis; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Narcotics; Oxidative Stress; Reactive Oxygen Species; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
The regulating manner of opioid receptors on distinct types of calcium channels in hamster submandibular ganglion cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium Channels; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Parasympathetic; Male; Naloxone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Submandibular Gland; Synaptic Transmission | 1998 |
Localized secretion of ATP and opioids revealed through single Ca2+ channel modulation in bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Antineoplastic Agents; Autocrine Communication; Barium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Cattle; Chromaffin Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exocytosis; Ion Channel Gating; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Opioid Peptides; Patch-Clamp Techniques; Peptides; Receptors, Opioid; Receptors, Purinergic; Spider Venoms; Suramin; Virulence Factors, Bordetella | 1998 |
Activation of opioid receptors inhibits neuronal-like calcium channels, distal steps of secretion, and cell proliferation in human small cell lung carcinoma cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Bucladesine; Calcium Channels; Carcinoma, Small Cell; Cell Division; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Lung Neoplasms; Naloxone; Neurons; Receptors, Opioid, delta; Serotonin; Thapsigargin; Time Factors; Tumor Cells, Cultured | 1998 |
Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Naloxone; Receptors, Cell Surface; Receptors, Opioid; Transfection | 1998 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
Effects of DPDPE (a specific delta-opioid receptor agonist) and naloxone on hypothalamic monoamine concentrations during the pre-ovulatory LH surge in the rat.
Topics: Animals; Biogenic Monoamines; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Follicular Phase; Hypothalamus; Luteinizing Hormone; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1998 |
Enkephalin receptors and receptor-mediated signal transduction in cultured human lymphocytes.
Topics: Calcium; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Lymphocytes; Naloxone; Receptors, Opioid; Signal Transduction | 1999 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Stimulation of phospholipase C by the cloned mu, delta and kappa opioid receptors via chimeric G alpha(q) mutants.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cloning, Molecular; COS Cells; DNA, Complementary; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Type C Phospholipases | 1999 |
Characterization of mechanical withdrawal responses and effects of mu-, delta- and kappa-opioid agonists in normal and mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Physical Stimulation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Substance Withdrawal Syndrome | 1999 |
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection | 1998 |
Opioid peptides inhibit the action of oestradiol on human myometrial cells in culture.
Topics: Adult; Cell Division; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Estradiol; Female; Humans; Inhibitory Concentration 50; Muscle, Smooth; Myometrium; Naloxone; Narcotic Antagonists; Progesterone | 1999 |
Differential desensitization of human delta-opioid receptors by peptide and alkaloid agonists.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Analgesics; Analgesics, Opioid; Cyclic AMP; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Humans; Naloxone; Neuroblastoma; Oligopeptides; Peptides; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the delta-opioid receptor.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Substitution; Animals; Aspartic Acid; Binding, Competitive; Chlorocebus aethiops; Codon; Colforsin; COS Cells; Cyclic AMP; Diprenorphine; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ligands; Mice; Mutagenesis, Site-Directed; Naloxone; Pertussis Toxin; Point Mutation; Protein Binding; Receptors, Opioid, delta; Recombinant Fusion Proteins; Second Messenger Systems; Transfection; Virulence Factors, Bordetella | 1999 |
Potentiation of anaphylaxis in guinea pig ileal mucosa by a selective delta-opioid receptor agonist.
Topics: Analgesics; Anaphylaxis; Animals; Anti-Allergic Agents; Cricetinae; Diphenhydramine; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Ileum; In Vitro Techniques; Lactoglobulins; Male; Milk; Mucous Membrane; Naloxone; Narcotic Antagonists; Ovalbumin; Saxitoxin | 1999 |
A DPDPE-induced enhancement of inward rectifier potassium current via opioid receptor in neuroblastomaxglioma NG108-15 cells.
Topics: Animals; Electric Conductivity; Electrodes; Enkephalin, D-Penicillamine (2,5)-; Guanosine Diphosphate; Mice; Naloxone; Narcotic Antagonists; Patch-Clamp Techniques; Pertussis Toxin; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Opioid; Thionucleotides; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2000 |
Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics, Opioid; Blotting, Western; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Opioid, delta; Time Factors | 2000 |
Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.
Topics: Analgesics, Opioid; Animals; Antimetabolites; Apoptosis; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Mice; Microscopy, Electron; Morphine; Naloxone; Narcotic Antagonists; Neurites; Neurons; Oligopeptides; Opioid-Related Disorders; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Stem Cells | 2000 |
mu-Opioid receptor inhibits N-type Ca2+ channels in the calyx presynaptic terminal of the embryonic chick ciliary ganglion.
Topics: Analgesics, Opioid; Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Chick Embryo; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Excitatory Postsynaptic Potentials; Ganglia, Parasympathetic; Naloxone; Narcotic Antagonists; Neural Inhibition; omega-Conotoxin GVIA; Patch-Clamp Techniques; Presynaptic Terminals; Receptors, Opioid, mu; Synaptic Transmission | 2000 |
Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics, Opioid; Animals; Barium; Biological Clocks; Calcium; Calcium Channels; Cell Line; Cesium; Enkephalin, D-Penicillamine (2,5)-; Enzyme-Linked Immunosorbent Assay; Naloxone; Narcotic Antagonists; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Prolactin; Quaternary Ammonium Compounds; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Virulence Factors, Bordetella | 2000 |
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.
Topics: Animals; Binding, Competitive; Blotting, Western; CHO Cells; COS Cells; Cricetinae; Dimerization; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanine Nucleotides; Naloxone; Pertussis Toxin; Polymers; Protein Conformation; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella | 2000 |
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2000 |
Morphine modulation of plasmodial-antigens-induced colony-stimulating factors production by macrophages.
Topics: Adjuvants, Immunologic; Analgesics, Opioid; Animals; Antigens, Protozoan; Colony-Stimulating Factors; Cycloheximide; Dose-Response Relationship, Immunologic; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Kinetics; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Morphine; Naloxone; Narcotic Antagonists; Plasmodium berghei; Protein Synthesis Inhibitors; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes | 2000 |
Identification of an opioid peptide secreted by rat embryonic mixed brain cells as a promoter of macrophage migration.
Topics: Analgesics, Opioid; Animals; Brain; Cells, Cultured; Chemotaxis, Leukocyte; Culture Media, Conditioned; Enkephalin, D-Penicillamine (2,5)-; Gene Expression Regulation, Developmental; Macrophages; Microglia; Naloxone; Narcotic Antagonists; Oligonucleotide Probes; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid, delta; RNA, Messenger; Stem Cells | 2000 |
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans.
Topics: Acids; Analgesics; Analgesics, Opioid; Animals; Cell Differentiation; CHO Cells; Cricetinae; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Fentanyl; Humans; Naloxone; Narcotic Antagonists; Neuroblastoma; Neurons; Tumor Cells, Cultured | 2001 |
Pharmacological effects of naltriben as a ligand for opioid mu and kappa receptors in rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Norepinephrine; Peptide Fragments; Peptides; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tritium | 2001 |
Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Autocrine Communication; Calcium; Calcium Channels, L-Type; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; GABA Antagonists; Isoquinolines; Kinetics; Naloxone; Narcotic Antagonists; Patch-Clamp Techniques; Picrotoxin; Protein Kinase Inhibitors; Sulfonamides; Suramin | 2001 |
Inhibition of calcium channels by opioid- and adenosine-receptor agonists in neurons of the nucleus accumbens.
Topics: Adenosine; Analgesics, Opioid; Animals; Barium; Calcium Channel Blockers; Calcium Channels; Cell Size; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Ethylmaleimide; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Interneurons; Ion Channel Gating; Naloxone; Narcotic Antagonists; Neostriatum; Neurons; Nucleus Accumbens; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Purinergic P1; Signal Transduction | 2001 |
Potentiation of opioid analgesia in dopamine2 receptor knock-out mice: evidence for a tonically active anti-opioid system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Opioid; Animals; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Heterozygote; Mice; Mice, Knockout; Morphine; Naloxone; Nociceptin; Oligonucleotides, Antisense; Opioid Peptides; Pain Measurement; Pentazocine; Receptors, Dopamine D2; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Sulpiride | 2001 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Spinal Cord | 2002 |
Chronic agonist treatment converts antagonists into inverse agonists at delta-opioid receptors.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cell Line; Cell Membrane; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Receptors, Opioid, delta; Receptors, Opioid, mu | 2002 |
Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Naloxone; Narcotic Antagonists; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 2003 |
Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Decanoic Acids; Disease Models, Animal; Drug Antagonism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Hydroxy Acids; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Naloxone; Potassium Channels; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, delta; Sclerosis; Ventricular Fibrillation | 2003 |
[Dual regulation by delta opioid receptor agonists on the delayed rectified potassium channels in NG108-15 cells].
Topics: Animals; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neuroblastoma; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured | 2003 |
Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Benzeneacetamides; Benzimidazoles; Bisbenzimidazole; Carbocyanines; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Glutamic Acid; Glutathione; Hydrogen Peroxide; Ion Channels; Microscopy, Fluorescence; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morphine; Naloxone; Narcotic Antagonists; Neuroglia; Oxidation-Reduction; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123 | 2004 |
The delta-opioid receptor participates in T-cell development by promoting negative selection.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; CD4 Antigens; CD8 Antigens; Cell Count; Cell Differentiation; Drug Interactions; Embryo, Mammalian; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enterotoxins; Flow Cytometry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Naloxone; Narcotic Antagonists; Organ Culture Techniques; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Opioid, delta; T-Lymphocytes; Thymus Gland | 2004 |
The stimulatory effect of mu- and delta-opioid receptors on bovine pinealocyte melatonin synthesis.
Topics: Acetyltransferases; Analgesics, Opioid; Animals; Cattle; Cells, Cultured; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Melatonin; Naloxone; Narcotic Antagonists; Pineal Gland; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Extracellular Space; Free Radicals; Glutamic Acid; Male; Microdialysis; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Pain; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Reserpine | 2005 |
Melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by increasing the release of beta-endorphin an endogenous opioid.
Topics: Analgesics; Analgesics, Opioid; Animals; beta-Endorphin; Binding, Competitive; Brain; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme-Linked Immunosorbent Assay; Melatonin; Mice; Naloxone; Nociceptin; Opioid Peptides; Pineal Gland; Radioligand Assay; Rats; Receptors, Opioid; Subcellular Fractions; Time Factors; Tritium | 2005 |
Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Afferent Pathways; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Functional Laterality; Immunochemistry; In Vitro Techniques; Male; Microscopy, Confocal; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Spinal Nerve Roots; Substance P | 2005 |
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin | 2005 |
Delta and mu opioid receptors from the brain of a urodele amphibian, the rough-skinned newt Taricha granulosa: cloning, heterologous expression, and pharmacological characterization.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Endorphin; Brain Chemistry; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Molecular Sequence Data; Naloxone; Phylogeny; Receptors, Opioid, delta; Receptors, Opioid, mu; Salamandridae; Sequence Alignment | 2006 |
Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells.
Topics: Adenoviridae; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Protein alpha Subunit, Gi2; Immunoprecipitation; Mice; Naloxone; Neuroblastoma; Pertussis Toxin; Receptors, Opioid, delta; Tumor Cells, Cultured | 2006 |
Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells.
Topics: Animals; Anticholesteremic Agents; beta-Cyclodextrins; Brain; Caveolin 1; Cell Line, Tumor; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Etorphine; G(M1) Ganglioside; Hybrid Cells; Levorphanol; Membrane Microdomains; Membrane Proteins; Naloxone; Neurons; Oligopeptides; Receptors, Opioid, delta; Signal Transduction | 2007 |
Inhibitory and excitatory effects of micro-, delta-, and kappa-opioid receptor activation on breathing in awake turtles, Trachemys scripta.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Naloxone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiratory Mechanics; Tidal Volume; Turtles | 2008 |
Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Data Interpretation, Statistical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Formaldehyde; Injections, Intraperitoneal; Male; Mole Rats; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2009 |
Role of the opioid system in incentive downshift situations.
Topics: Analgesics, Opioid; Animals; Conditioning, Classical; Dietary Sucrose; Drinking Behavior; Enkephalin, D-Penicillamine (2,5)-; Extinction, Psychological; Feeding Behavior; Female; Goals; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Random Allocation; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Taste Perception; Time Factors | 2009 |
Involvement of peripheral mu opioid receptors in scratching behavior in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Antipruritics; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Injections, Intradermal; Loperamide; Male; Mice; Mice, Inbred ICR; Naloxone; Opioid-Related Disorders; Pruritus; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Skin | 2010 |
Dorsal hippocampal opioidergic system modulates anxiety-like behaviors in adult male Wistar rats.
Topics: Analgesics, Opioid; Animals; Anxiety; CA1 Region, Hippocampal; Disease Models, Animal; Enkephalin, D-Penicillamine (2,5)-; Male; Maze Learning; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2010 |
Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.
Topics: Acetylcysteine; Analgesics, Opioid; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Leupeptins; Naloxone; Narcotic Antagonists; Pertussis Toxin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-2; Receptors, Bradykinin; Receptors, Opioid, delta; Receptors, Opioid, mu; RGS Proteins; Signal Transduction; Time Factors; Ubiquitination | 2011 |
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenal Medulla; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Calmodulin-Dependent Protein Kinases; Carbonic Anhydrase I; Carbonic Anhydrase II; Cell Hypoxia; Cell Line; Chromaffin Cells; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Female; Hypercapnia; Indoles; Isoquinolines; KATP Channels; Maleimides; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Oligopeptides; Potassium Channels, Inwardly Rectifying; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2014 |
Differential effects of exercise on brain opioid receptor binding and activation in rats.
Topics: Amygdala; Animals; Benzeneacetamides; Brain Chemistry; Cerebral Cortex; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hypothalamus; Naloxone; Nerve Tissue Proteins; Opioid Peptides; Physical Conditioning, Animal; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid; Signal Transduction; Time Factors | 2015 |
Placement of Hydroxy Moiety on Pendant of Peptidomimetic Scaffold Modulates Mu and Kappa Opioid Receptor Efficacy.
Topics: Analgesics, Opioid; Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Naloxone; Peptidomimetics; Protein Binding; Protein Conformation; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2017 |
A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.
Topics: Analgesics, Opioid; Animals; Biosensing Techniques; Cell Membrane; Dendrites; Endosomes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Golgi Apparatus; HEK293 Cells; HeLa Cells; Humans; Intracellular Space; Microscopy, Fluorescence; Morphine; Naloxone; Narcotic Antagonists; Neurons; Peptides; Rats; Receptors, Opioid; Spatio-Temporal Analysis | 2018 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |
Characterization of the Synergistic Effect between Ligands of Opioid and Free Fatty Acid Receptors in the Mouse Model of Colitis.
Topics: Aniline Compounds; Animals; Butyrates; Colitis; Disease Models, Animal; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Inflammation; Ligands; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Peroxidase; Receptors, G-Protein-Coupled; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides; Thiophenes; Xanthenes | 2021 |