enkephalin, d-penicillamine (2,5)- has been researched along with enkephalin, methionine in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (13.43) | 18.7374 |
| 1990's | 43 (64.18) | 18.2507 |
| 2000's | 13 (19.40) | 29.6817 |
| 2010's | 2 (2.99) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, ZG; North, RA | 1 |
| Gintzler, AR; Xu, H | 3 |
| Akami, T; Arakawa, K; Matsumoto, S; Mitsuo, M; Nagase, H; Nakai, I; Nakajima, H; Oka, T; Okamoto, M | 1 |
| Haaseth, RC; Horan, P; Hruby, VJ; Matsunaga, TO; Porreca, F; Tallarida, RJ | 1 |
| Johnson, SW; North, RA | 1 |
| deCosta, B; Jiang, Q; Porreca, F; Rice, KC | 1 |
| Frank, C; Proietti, ML; Sagratella, S; Scotti De Carolis, A; Trampus, M | 1 |
| Hauser, KF; Stiene-Martin, A | 1 |
| Grider, JR; Makhlouf, GM | 1 |
| Bauer, AJ; Szurszewski, JH | 1 |
| Osborne, PB; Pan, ZZ; Williams, JT | 1 |
| Hill, JM; Kaufman, MP | 1 |
| Christie, MJ; North, RA; Surprenant, A; Williams, JT | 1 |
| Chen, HT; Louie, DS; Owyang, C | 1 |
| Burks, TF; Gehrig, CA; Hruby, VJ; Lemcke, PK; Shook, JE | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Gintzler, AR; Smolens, I; Xu, H | 1 |
| Delay-Goyet, P; Gacel, G; Roques, BP; Seguin, C | 1 |
| Kirby, GC; McQueen, DS | 1 |
| Fujiwara, M; Kurahashi, K; Okamoto, T | 1 |
| Duffy, P; Kalivas, PW; Latimer, LG | 1 |
| Chiappinelli, VA; Feng, C; McMahon, LL; Wolf, KM; Yum, L | 1 |
| Shahabi, NA; Sharp, BM | 1 |
| Hinson, JP; Kapas, S; Purbrick, A | 1 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Everitt, BJ; Phillips, GD; Robbins, TW | 1 |
| Nagasaka, H; Yaksh, TL | 1 |
| North, RA; Tanaka, E | 1 |
| Abbruscato, TJ; Brownson, EA; Davis, TP; Gillespie, TJ; Hruby, VJ | 1 |
| North, RA; Sugita, S | 1 |
| Dhar, MM; Mazumder, S; Nath, I | 1 |
| Goñalons, E; Jiménez, M; Martínez, V; Vergara, P | 1 |
| Amoroso, D; Catozzi, L; Ceppi, E; Groppetti, A; Guglielmetti, F; Palazzi, E | 1 |
| Endoh, T; Suzuki, T | 1 |
| Chang, KJ; Li, LY | 1 |
| Kow, LM; Pfaff, DW; Zhang, C | 1 |
| Casares, F; Liu, U; Stefano, GB | 1 |
| Franck, J; Nylander, I; Rosén, A | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Hebb, AL; Maddeaux, C; Marsh, NJ; Mendella, PD; Zacharko, RM | 1 |
| Aghajanian, GK; Marek, GJ | 1 |
| Finberg, RW; Heagy, W; Lopez, P; Teng, E | 1 |
| Burger, K; Chung, NN; Schiller, PW; Sewald, N; Winkler, D | 1 |
| Abramić, M; Balog, T; Hrsak, I; Marotti, T; Svoboda-Beusen, I | 1 |
| Kowalski, J | 1 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Malatynska, E; Porreca, F; Slaninova, J; Stropova, D; Yamamura, HI | 1 |
| Környei, JL; Kovács, KA; Oszter, A; Rao, CV; Vértes, M; Vértes, Z | 1 |
| Cooper, AJ; Stanford, IM | 1 |
| Banks, WA; Brown, TT; Kastin, AJ; Maresh, GA; Zadina, JE | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Elde, RP; Hauser, KF; Houdi, AA; Maxson, W; Turbek, CS | 1 |
| Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS | 1 |
| Bilfinger, TV; Magazine, HI; Murga, JD; Qi, F; Saeed, RW; Short, TW; Stefano, GB | 1 |
| Abramić, M; Balog, T; Beusan-Svoboda, I; Hrsak, I; Marotti, T; Sobocanec, S | 1 |
| Ito, S; Kai, T; Kitamura, G; Kon, Y; Ohta, T | 1 |
| Caffrey, JL; Farias, M; Jackson, KE; Yoshishige, D | 1 |
| Bogacka, I; Kaminski, T; Okrasa, S; Przala, J; Siawrys, G | 1 |
| Hempelmann, G; Hirsch, J; Menzebach, A; Welters, ID | 1 |
| Baugh, MM; Bradford, CS; Moore, FL; Stanley, DJ; Walthers, EA | 1 |
| Devidze, N; Kow, LM; Lee, AW; Pataky, S; Pfaff, DW; Zhang, Q; Zhou, J | 1 |
| Bradbury, FA; Traynor, JR; Zelnik, JC | 1 |
| Campbell, AM; McLaughlin, PJ; Zagon, IS | 1 |
| Celik, MÖ; Labuz, D; Machelska, H; Zimmer, A | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Belanger, S; DeHaven, RN; Dolle, RE; Graczyk, TM; Martinez-Teipel, B; Michaut, M | 1 |
67 other study(ies) available for enkephalin, d-penicillamine (2,5)- and enkephalin, methionine
| Article | Year |
|---|---|
Pre- and postsynaptic inhibition by opioids in rat striatum.
Topics: Action Potentials; Animals; Corpus Striatum; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Male; Membrane Potentials; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synapses | 1992 |
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil | 1992 |
Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.
Topics: Analgesics; beta-Endorphin; Cell Survival; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; Indoles; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity.
Topics: Analgesics; Animals; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Opioids excite dopamine neurons by hyperpolarization of local interneurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Bicuculline; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Mesencephalon; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses | 1992 |
Effects of oxymorphindole on morphine induced-antinociception in mice and rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mice; Morphine; Morpholines; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
An in vitro study on the hippocampal epileptogenic properties of enkephalins and enkephalinase inhibitors in rats.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Epilepsy; Hippocampus; In Vitro Techniques; Male; Morphine; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro.
Topics: Analgesics; Animals; Animals, Newborn; Astrocytes; Benzeneacetamides; Cells, Cultured; DNA Replication; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Mice, Inbred ICR; Neuroglia; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thymidine | 1991 |
Identification of opioid receptors on gastric muscle cells by selective receptor protection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Stomach | 1991 |
Effect of opioid peptides on circular muscle of canine duodenum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Muscles; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid | 1991 |
Opioids can produce a concentration-dependent naloxone-reversible enhancement of inhibition of evoked enkephalin release.
Topics: Analgesics; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Naloxone; Narcotics; Parasympatholytics; Sufentanil; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle, Smooth; Myenteric Plexus; Narcotics; Pertussis Toxin; Pyrrolidines; Sufentanil; Virulence Factors, Bordetella | 1991 |
Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Medulla Oblongata; Morphine; Neurons; Quinoxalines; Rats | 1990 |
Attenuation of reflex pressor and ventilatory responses to static muscular contraction by intrathecal opioids.
Topics: Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Heart Rate; Injections, Spinal; Muscle Contraction; Respiration; Sciatic Nerve | 1990 |
Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.
Topics: Animals; beta-Endorphin; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Ion Channels; Locus Coeruleus; Membrane Potentials; Narcotics; Neurons; Potassium; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Inhibition of exocrine pancreatic secretion by opiates is mediated by suppression of cholinergic transmission: characterization of receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Amylases; Animals; Cholinergic Fibers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Narcotics; Pancreas; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptic Transmission | 1988 |
Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antidiarrheals; Constipation; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.
Topics: Action Potentials; Animals; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Myenteric Plexus; Naloxone; Sufentanil | 1989 |
[3H][D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6(O-tert-butyl). Two new enkephalin analogs with both a good selectivity and a high affinity toward delta-opioid binding sites.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Kinetics; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hypercapnia; Hypoxia; Peptide Fragments; Receptors, Opioid | 1986 |
Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats.
Topics: Animals; Cats; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Narcotic Antagonists; Narcotics; Peptide Fragments; Stomach; Vagus Nerve | 1988 |
Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Motor Activity; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tegmentum Mesencephali | 1987 |
Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons.
Topics: Amino Acid Sequence; Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; GTP-Binding Proteins; In Vitro Techniques; Molecular Sequence Data; Naloxone; Nerve Endings; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Reticular Formation; Substance P | 1993 |
Delta opioid agonists inhibit proliferation of highlypurified murine CD4+ and CD8+ T-cells.
Topics: Analgesics; Animals; CD4 Antigens; CD8 Antigens; Cell Division; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; T-Lymphocytes | 1995 |
Action of opioid peptides on the rat adrenal cortex: stimulation of steroid secretion through a specific mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Cortex; Aldosterone; Analgesics; Animals; beta-Endorphin; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Opioid Peptides; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Mesoaccumbens dopamine-opiate interactions in the control over behaviour by a conditioned reinforcer.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Dextroamphetamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Ergolines; Injections; Male; Nucleus Accumbens; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid; Tegmentum Mesencephali | 1994 |
Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Anesthesia, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Halothane; Heart Rate; Hot Temperature; Injections, Spinal; Male; Morphine; Nalbuphine; Nociceptors; Pain Threshold; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Reflex; Thiophenes | 1995 |
Opioid actions on rat anterior cingulate cortex neurons in vitro.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glutamates; Glutamic Acid; Gyrus Cinguli; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Neurotransmitter Agents; Rats; Receptors, Opioid; Somatostatin; Synapses; Synaptic Transmission | 1994 |
Effect of peptidases at the blood brain barrier on the permeability of enkephalin.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Cattle; CD13 Antigens; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Molecular Sequence Data; Neprilysin; Peptidyl-Dipeptidase A | 1994 |
Opioid actions on neurons of rat lateral amygdala in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Amino Acids; Amygdala; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; GABA-A Receptor Antagonists; In Vitro Techniques; Molecular Sequence Data; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pyrrolidines; Rats; Somatostatin; Synapses | 1993 |
Immunomodulation of human T cell responses with receptor selective enkephalins.
Topics: Adjuvants, Immunologic; Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; In Vitro Techniques; Leprosy; Lymphocyte Activation; Molecular Sequence Data; Opioid Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Receptors, Opioid, mu; Rosette Formation; T-Lymphocytes; Tuberculosis, Pulmonary | 1993 |
In vivo modulation of gastrointestinal motor activity by Met-enkephalin, morphine and enkephalin analogs in chickens.
Topics: Amino Acid Sequence; Animals; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Immunohistochemistry; Male; Molecular Sequence Data; Morphine; Motor Activity; Naloxone; Nerve Fibers; Vagotomy; Vagus Nerve | 1993 |
Biochemical evidence of functional interaction between mu- and delta-opioid receptors in SK-N-BE neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Membrane Proteins; Neuroblastoma; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors; Tumor Cells, Cultured | 1996 |
The effects of delta-opioid receptor agonists on synaptic transmission in hamster submandibular ganglion.
Topics: Animals; Autonomic Fibers, Preganglionic; Cricetinae; Dimethylphenylpiperazinium Iodide; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; Ganglionic Stimulants; Naloxone; Narcotic Antagonists; Presynaptic Terminals; Receptors, Opioid, delta; Submandibular Gland; Synaptic Transmission | 1995 |
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1996 |
Functional analysis of opioid receptor subtypes in the ventromedial hypothalamic nucleus of the rat.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Ventromedial Hypothalamic Nucleus | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
Met-enkephalin inhibits 5-hydroxytryptamine release from the rat ventral spinal cord via delta opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Serotonin; Spinal Cord | 1996 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Vulnerability to stressor-induced disturbances in self-stimulation from the dorsal and ventral A10 area: differential effects of intraventricular D-Ala2-Met5-enkephalinamide, D-Ala2, N-Me-Phe4, Gly-Ol5-enkephalin, and D-Pen2, D-Pen5-enkephalin administrat
Topics: Animals; Electric Stimulation; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Foot; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu; Self Stimulation; Stress, Physiological; Tegmentum Mesencephali; Time Factors | 1998 |
5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by mu-opiate receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Models, Neurological; Neocortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptors, Opioid, mu; Receptors, Serotonin; Serotonin; Somatostatin; Synapses | 1998 |
Enkephalin receptors and receptor-mediated signal transduction in cultured human lymphocytes.
Topics: Calcium; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Lymphocytes; Naloxone; Receptors, Opioid; Signal Transduction | 1999 |
Enkephalin analogs containing 4,4-difluoro-2-aminobutyric acid: synthesis and fluorine effect on the biological activity.
Topics: Aminobutyrates; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fluorine; Guinea Pigs; Ileum; Male; Mice; Models, Chemical; Receptors, Opioid, delta; Vas Deferens | 1998 |
The role of aminopeptidase N in Met-enkephalin modulated superoxide anion release.
Topics: Adult; Analgesics; Analgesics, Opioid; CD13 Antigens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Leucine; Male; Neutrophils; Oligopeptides; Protease Inhibitors; Superoxides | 1999 |
Augmenting effect of opioids on nitrite production by stimulated murine macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitrites; Opioid Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.
Topics: Animals; Biological Assay; Chemistry, Pharmaceutical; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Peptide Biosynthesis; Protein Binding; Protein Precursors; Receptors, Opioid, delta; Vas Deferens | 1999 |
Opioid peptides inhibit the action of oestradiol on human myometrial cells in culture.
Topics: Adult; Cell Division; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Estradiol; Female; Humans; Inhibitory Concentration 50; Muscle, Smooth; Myometrium; Naloxone; Narcotic Antagonists; Progesterone | 1999 |
Presynaptic mu and delta opioid receptor modulation of GABAA IPSCs in the rat globus pallidus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analgesics, Opioid; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Excitatory Amino Acid Antagonists; GABA Antagonists; Globus Pallidus; In Vitro Techniques; Male; Membrane Potentials; Neostriatum; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Synaptic Transmission; Tetrodotoxin | 1999 |
Peptide transport system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Capillaries; Carrier Proteins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Iodine Radioisotopes; Male; Mice; Mice, Inbred ICR; MSH Release-Inhibiting Hormone; Receptors, Opioid; Thyrotropin-Releasing Hormone; Tyrosine | 1999 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.
Topics: Analgesics, Opioid; Animals; Antimetabolites; Apoptosis; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Mice; Microscopy, Electron; Morphine; Naloxone; Narcotic Antagonists; Neurites; Neurons; Oligopeptides; Opioid-Related Disorders; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Stem Cells | 2000 |
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2000 |
Expression of functional delta opioid receptors in vascular smooth muscle.
Topics: Animals; Aorta; Binding, Competitive; Calcium; Cell Line; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gene Expression; Humans; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Vasoconstriction | 2000 |
Neutrophil neutral endopeptidase variation and its regulation by opioid peptides.
Topics: Adult; Alkaline Phosphatase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Humans; In Vitro Techniques; Neprilysin; Neutrophils; Subcellular Fractions | 2001 |
Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Animals; Barium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, N-Type; Calcium Signaling; Catecholamines; Chromaffin Cells; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Potentials; Narcotics; Neural Inhibition; Potassium Chloride; Receptors, Opioid; RNA, Messenger; Swine | 2002 |
Cardiac enkephalins interrupt vagal bradycardia via delta 2-opioid receptors in sinoatrial node.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzylidene Compounds; Bradycardia; Dogs; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Quinolines; Receptors, Opioid, delta; Sinoatrial Node; Vagus Nerve | 2003 |
The regulation of steroidogenesis by opioid peptides in porcine theca cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; Cells, Cultured; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Estradiol; Female; Opioid Peptides; Progesterone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Steroids; Swine; Testosterone; Theca Cells | 2003 |
Effects of endogenous and synthetic opioid peptides on neutrophil function in vitro.
Topics: Antigens, CD; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Flow Cytometry; Humans; Male; Neutrophil Activation; Neutrophils; Opioid Peptides; Peptide Fragments; Somatostatin; Superoxides | 2003 |
Delta and mu opioid receptors from the brain of a urodele amphibian, the rough-skinned newt Taricha granulosa: cloning, heterologous expression, and pharmacological characterization.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Endorphin; Brain Chemistry; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Molecular Sequence Data; Naloxone; Phylogeny; Receptors, Opioid, delta; Receptors, Opioid, mu; Salamandridae; Sequence Alignment | 2006 |
Presynaptic actions of opioid receptor agonists in ventromedial hypothalamic neurons in estrogen- and oil-treated female mice.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Estradiol; Estrogens; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Mice; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Oils; Ovariectomy; Patch-Clamp Techniques; Presynaptic Terminals; Ventromedial Hypothalamic Nucleus | 2008 |
G protein independent phosphorylation and internalization of the delta-opioid receptor.
Topics: Analgesics, Opioid; Arrestins; Benzamides; beta-Arrestin 2; beta-Arrestins; Cell Line, Transformed; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Green Fluorescent Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Oligopeptides; Pertussis Toxin; Phosphorylation; Piperazines; Protein Binding; Protein Transport; Quinolines; Receptors, Opioid, delta; Serine; Sulfur Isotopes; Transfection | 2009 |
Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Encephalomyelitis, Autoimmune, Experimental; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Female; Gene Expression Regulation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Narcotic Antagonists; Necrosis; Nitric Oxide; Peptides; Receptors, Opioid; RNA, Small Interfering; Time Factors | 2013 |
Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; beta-Endorphin; Corticotropin-Releasing Hormone; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Hot Temperature; Male; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Opioid Peptides; Peripheral Nervous System; Receptors, Opioid | 2016 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Further studies of tyrosine surrogates in opioid receptor peptide ligands.
Topics: Chemistry, Pharmaceutical; Cloning, Molecular; Drug Design; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Chemical; Molecular Conformation; Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tyrosine | 2007 |