enkephalin, d-penicillamine (2,5)- has been researched along with enkephalin, leucine in 909 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 156 (17.16) | 18.7374 |
| 1990's | 723 (79.54) | 18.2507 |
| 2000's | 26 (2.86) | 29.6817 |
| 2010's | 4 (0.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Maixner, W; Suarez-Roca, H | 1 |
| Jiang, ZG; North, RA | 1 |
| Grossman, A; Hucks, D; Joel, SP; McLoughlin, L; Patel, N; Rees, LH; Slevin, ML; Thompson, PI | 1 |
| Bowen, WD; Farmer, SC; Mattia, A; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 7 |
| Gintzler, AR; Xu, H | 3 |
| Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L | 1 |
| Borsodi, A; Búzás, B; Cavagnero, S; Hruby, VJ; Tóth, G | 1 |
| Akami, T; Arakawa, K; Matsumoto, S; Mitsuo, M; Nagase, H; Nakai, I; Nakajima, H; Oka, T; Okamoto, M | 1 |
| Green, IC; Khawaja, XZ | 1 |
| Haaseth, RC; Horan, P; Hruby, VJ; Matsunaga, TO; Porreca, F; Tallarida, RJ | 1 |
| Collins, KA; Tseng, LF | 1 |
| Law, PY; Loh, HH; Roerig, SC | 1 |
| Madamba, S; Siggins, GR; Yuan, XR | 1 |
| Levine, JD; Miaskowski, C; Sutters, KA; Taiwo, YO | 3 |
| Eriksson, PS; Hansson, E; Rönnbäck, L | 2 |
| Heller, PH; Levine, JD; Taiwo, YO | 1 |
| Churchill, L; Kalivas, PW | 1 |
| Aoki, T; Kamei, J; Kasuya, Y; Kawasima, N; Ohhashi, Y | 1 |
| Xu, R | 1 |
| Ko, JL; Lee, NM; Loh, HH | 1 |
| Burks, TF; Davis, P; Fang, L; Hruby, VJ; Knapp, R; Kramer, TH; Landis, G; Russell, KC; Toth, G; Yamamura, HI | 1 |
| Aloyo, VJ | 1 |
| Dondi, D; Limonta, P; Maggi, R; Martini, L; Piva, F | 1 |
| Olianas, MC; Onali, P | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 2 |
| Anthony, E; Beardsley, PM; Chandrakumar, NS; Drury, B; Lopez, OT; Reichman, M; Savage, MA; Stapelfeld, A; Williamson, LN | 1 |
| Kuemmerle, JF; Makhlouf, GM | 1 |
| Cheng, PY; Cheng, Y; Decena, J; McCabe, S; Szeto, HH; Wu, DL | 1 |
| Fan, LQ; Hiller, JM; Ofri, D; Simon, EJ | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 2 |
| Costa, EM; Hoffman, BB; Loew, GH | 1 |
| Green, PG; Levine, JD | 1 |
| Crook, TJ; Hill, RG; Kitchen, I | 1 |
| Crain, SM; Fan, SF; Scheideler, MA; Shen, KF | 1 |
| Martinez, RP; Porreca, F; Raffa, RB | 1 |
| Chaki, K; Kisara, K; Nakata, N; Sakurada, S; Sakurada, T; Suzuki, K; Watanabe, H | 1 |
| Besse, D; Besson, JM; Lombard, MC; Perrot, S | 1 |
| Elde, R; Lane, CM; Lee, NM; Loh, HH | 1 |
| Laorden, ML; Micol, JA | 2 |
| Levine, JD; Miaskowski, C | 2 |
| Mosberg, HI; Porreca, F; Raffa, RB; Wild, KD | 2 |
| DeLander, GE; Mosberg, HI; Porreca, F | 1 |
| Edwards, RH; Evans, CJ; Keith, DE; Magendzo, K; Morrison, H | 1 |
| Cabral, JD; Leedham, JA; Monroe, PJ; Robertson, B; Smith, DJ; Taylor, DA | 1 |
| Besse, D; Besson, JM; Butler, SH; Lombard, MC; Weil-Fugazza, J | 1 |
| Pfaff, DW; Pfaus, JG | 1 |
| Jin, W; Lee, NM; Loh, HH; Thayer, SA | 2 |
| Bakker, JM; Heijna, MH; Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Billings, B; Candido, J; Duttaroy, A; Lutfy, K; Sierra, V; Yoburn, BC; Zito, SW | 1 |
| Johnson, SW; North, RA | 1 |
| Gnegy, ME; Mangels, LA | 1 |
| Kasai, H | 2 |
| Gannon, RL; Terrian, DM | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Costa, M; Tonini, M; Waterman, SA | 1 |
| Dubner, R; Hylden, JL; Ren, K; Ruda, MA; Williams, GM | 1 |
| Leslie, FM; Loughlin, SE; Smith, JA | 1 |
| Bot, G; Brent, PJ; Chahl, LA; Johnston, PA | 1 |
| Dunwiddie, TV; Lupica, CR; Proctor, WR | 1 |
| Adler, MW; Geller, EB; Handler, CM | 1 |
| Cunningham, ST; Kelley, AE | 1 |
| Hudson, GM; Marquis, KL; Stamidis, H; Young, GA | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N | 1 |
| Davis, TP; Greene, DL; Hruby, VJ; Porreca, F; Weber, SJ; Yamamura, HI | 1 |
| Pettitt, BM; Smith, PE | 1 |
| Han, JS; Ren, MF; Sun, XJ; Wang, JF; Yang, HF | 1 |
| Dubner, R; Iwata, K; Kenshalo, DR; Thomas, DA; Williams, GM | 1 |
| Haaseth, RC; Hruby, VJ; Matsunaga, TO; O'Brien, DF; Ramaswami, V | 1 |
| Bot, G; Brent, PJ | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY | 1 |
| Bowen, WD; Jiang, Q; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Candido, J; Lutfy, K; Yoburn, BC | 1 |
| Mosberg, HI; Porreca, F; Vanderah, T; Wild, KD | 1 |
| Jhamandas, K; Ruzicka, BB | 2 |
| Burks, TF; Davis, P; Gehrig, CA; Hruby, VJ; Kao, LF; Knapp, R; Kramer, TH; Lui, GK; Toth, G; Yamamura, HI | 1 |
| Lazarus, LH; Salvadori, S; Tomatis, R; Wilson, WE | 1 |
| Christensen, CB; Reiff, L | 1 |
| Dissanayake, VU; Hughes, J; Hunter, JC | 1 |
| Gulya, K; Kása, P; Kovács, GL | 2 |
| Burks, TF; Cavagnero, S; Davis, P; Fang, L; Hruby, VJ; Knapp, RJ; Misicka, A; Yamamura, HI | 1 |
| Mjanger, E; Yaksh, TL | 1 |
| Mattia, A; Mosberg, HI; Porreca, F; Vanderah, T | 1 |
| Bridges, RS; Kinsley, CH; Mann, PE | 1 |
| Drukarch, B; Mulder, AH; Ruuls, SR; Schoffelmeer, AN; Van Vliet, BJ | 1 |
| Gehrig, CA; Hruby, VJ; Prakash, O; Toth, G | 1 |
| deCosta, B; Jiang, Q; Porreca, F; Rice, KC | 1 |
| Hoffman, DC; West, TE; Wise, RA | 1 |
| Elde, RP; Lacey, CB; Miller, KE; Seybold, VS; Stevens, CW | 1 |
| Corsi, R; Melchiorri, P; Negri, L; Potenza, RL | 1 |
| Dunwiddie, TV; Lupica, CR | 1 |
| Collins, JG; Kitahata, LM; Nakatani, K; Omote, K | 1 |
| Frank, C; Proietti, ML; Sagratella, S; Scotti De Carolis, A; Trampus, M | 1 |
| de Costa, BR; Drower, EJ; Hammond, DL; Rafferty, MF; Rice, KC; Stapelfeld, A | 1 |
| Cone, RI; Lameh, J; Sadée, W | 1 |
| Matsuyama, S; Nakayama, S; Sano, I; Takeda, K; Tanaka, C; Taniyama, K; Yoshihara, C | 1 |
| Bhargava, HN; Gulati, A; Rahmani, NH | 1 |
| Gratton, A; Pentney, RJ | 1 |
| Bennett, GJ; Kajander, KC; Seybold, VS; Stevens, CW | 1 |
| Barr, GA; Carden, SE; Hofer, MA | 1 |
| Gonzalvez, ML; Milanés, MV; Vargas, ML | 2 |
| Franck, LS; Levine, JD; Miaskowski, C; Putris, J | 1 |
| Burks, TF; Davis, P; Delaet, N; Kramer, TH; Tourwe, D | 1 |
| Hauser, KF; Stiene-Martin, A | 1 |
| Imanishi, Y; Kimura, S; Sasaki-Yagi, Y | 1 |
| Cowan, A; Li, SX; Liu-Chen, LY; Wheeler-Aceto, H | 1 |
| Bousselmame, R; Costentin, J; Michael-Titus, A | 1 |
| Enger, M; Grynne, BH; Holmen, AT; Maurset, AR | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Levine, JD; Miaskowski, C; Taiwo, YO | 3 |
| Grider, JR; Makhlouf, GM | 1 |
| Hattori, Y; Katafuchi, T; Koizumi, K | 1 |
| Adams, JU; Holtzman, SG | 2 |
| Bauer, AJ; Szurszewski, JH | 1 |
| Jacobson, AE; Ni, Q; Rice, KC; Rothman, RB; Xu, H | 1 |
| Kapoor, R; Willoughby, JO | 1 |
| Crain, SM; Fan, SF; Shen, KF | 2 |
| Alberch, J; Arenas, E; Marsal, J | 2 |
| Barnes, PJ; Belvisi, MG; Stretton, CD | 1 |
| Duan, DS; Eiger, S; Lameh, J; Sadée, W; Yu, VC | 1 |
| Brown, DR; Quito, FL | 2 |
| Jones, AJ; Keen, P; Ray, NJ | 1 |
| Fox, AJ; Morton, IK | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A | 1 |
| Burks, TF; Davis, TP; Greene, DL; Hersh, LB; Hruby, VJ; Kramer, TH; Sharma, SD; Weber, SJ; Yamamura, HI | 1 |
| al-Obeidi, F; Gehrig, C; Hruby, VJ; Karplus, M; Matsunaga, T; Pettitt, BM | 1 |
| Gehrig, CA; Hruby, VJ; Nikiforovich, GV; Prakash, O | 1 |
| Schiller, PW; Wilkes, BC | 1 |
| Fischbach, PS; McCleskey, EW; Schroeder, JE; Zheng, D | 1 |
| Fujimoto, JM; Rady, JJ; Roerig, SC | 1 |
| Burks, TF; Davis, P; Haaseth, RC; Hruby, VJ; Kramer, TH; Matsunaga, TO; Toth, G | 1 |
| Butt, W; Cowan, A; Fisher, RS; Krevsky, B; Maurer, AH | 1 |
| Cowan, A; Murray, CW | 2 |
| Duckles, SP; Li, YJ | 1 |
| Alberch, J; Arenas, E; Marsal, J; Pérez-Navarro, E; Solsona, C | 1 |
| Glowinski, J; Lévy, M; Trovero, F | 1 |
| Lee, AY; Tai, KK; Wong, TM | 1 |
| Lawrence, AJ; Traynor, JR | 1 |
| Bals-Kubik, R; Herz, A; Shippenberg, TS | 2 |
| Gosnell, BA; Krahn, DD; Majchrzak, MJ | 1 |
| Collins, JG; Kitahata, LM; Nakagawa, I; Nakatani, K; Omote, K | 1 |
| Amerini, S; Ledda, F; Mantelli, L; Rubino, A | 1 |
| Giuliani, S; Maggi, CA; Meli, A | 1 |
| Suh, HH; Tseng, LF | 3 |
| Han, JS; Wang, XH; Wang, XJ | 1 |
| Alberch, J; Arenas, E; Marsal, J; Sanchez Arroyos, R | 1 |
| Herz, A; Shippenberg, TS; Spanagel, R | 2 |
| Birch, PJ; Hayes, AG; Lawrence, AJ; Rogers, H; Traynor, JR | 1 |
| Osborne, PB; Pan, ZZ; Williams, JT | 1 |
| Bird, ED; Crino, PB; Plager, MD; Vogt, BA | 1 |
| Dilts, RP; Kalivas, PW | 1 |
| Han, JS; Wang, XJ; Zhang, LJ | 1 |
| Henderson, G; Rogers, H | 1 |
| Chew, C; Loew, GH; Villar, HO | 2 |
| Calcagnetti, DJ; Holtzman, SG | 1 |
| Burks, TF; Lemcke, PK; Shook, JE | 1 |
| Froimowitz, M | 1 |
| Burks, TF; Davis, P; Hruby, VJ; Knapp, R; Kramer, TH; Lui, G; Toth, G; Yamamura, HI | 1 |
| Barg, J; Hatini, V; Simantov, R | 1 |
| Heijna, MH; Mulder, AH; Schoffelmeer, AN | 1 |
| Berzetei-Gurske, I; Loew, GH | 1 |
| Jiang, Q; Mosberg, HI; Porreca, F | 2 |
| Ayres, EA; Burks, TF; Hruby, VJ; Kramer, TH; Toth, G | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY; Rohrbach, KW | 1 |
| Coscia, CJ; Szücs, M | 1 |
| Bowen, WD; Calcagnetti, DJ; Holtzman, SG | 1 |
| Durie, E; Michel, AD; Sharif, NA; Whiting, RL | 1 |
| Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN | 1 |
| Starke, K; Wichmann, T | 1 |
| Jiang, Q; Porreca, F; Sheldon, RJ | 1 |
| Knapp, RJ; Yamamura, HI | 1 |
| Henry, JL; Rochford, J | 1 |
| Bodnar, RJ; Pasternak, GW; Paul, D | 1 |
| Cai, LQ; Szeto, HH; Zhu, YS | 1 |
| Mickley, GA; Mulvihill, MA; Postler, MA | 1 |
| Fields, KL; Kessler, JA; Vaysse, PJ; Zukin, RS | 1 |
| Baba, A; Doi, M; Inoue, M; Ishida, T; Iwata, H; Katagawa, Y; Kitamura, K; Sadatome, T; Yara, H; Yasuda, M | 1 |
| Magnan, J; Tiberi, M | 2 |
| Hill, RG; Hughes, J; Hunter, JC; Rodriguez, RE; Traynor, JR | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Mosberg, HI; Porreca, F; Qi, JN | 1 |
| Han, JS; Wang, XJ | 1 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Mosberg, HI; Porreca, F; Qi, JA | 1 |
| Gallo, RV; Mallory, DS | 1 |
| Medzihradsky, F; Nordby, GL; Remmers, AE | 1 |
| Bowen, WD; Mosberg, HI; Porreca, F; Qi, JA; Rothman, RB | 1 |
| Hahn, EF; Howard, DH; Levison, JA; Pasternak, GW; Paul, D; Pick, CG | 1 |
| Coombes, JE; Pumford, KM; Russell, JA; Sumner, BE | 1 |
| Haaseth, RC; Heyl, DL; Medzihradsky, F; Mosberg, HI; Omnaas, JR; Smith, CB | 1 |
| Attali, B; Barg, J; Simantov, R; Vogel, Z | 1 |
| Fleetwood-Walker, SM; Hope, PJ; Mitchell, R | 1 |
| Bourne, RC; Csillag, A; Stewart, MG | 1 |
| Fan, LQ; Hiller, JM; Simon, EJ | 2 |
| Duan, SM; Fukuda, A; Hori, T; Oomura, Y; Shimizu, N | 1 |
| Haaseth, RC; Medzihradsky, F; Mosberg, HI; Smith, CB; Sobczyk-Kojiro, K | 1 |
| Ayres, EA; Burks, TF; Davis, P | 1 |
| Barnette, MS; Barone, FC; Callahan, JF; Grous, M; Manning, CD | 1 |
| Green, J; Harris, S; Lloyd, P; Lozito, R; Messineo, E; Ossipov, MH | 1 |
| Burks, TF; Hruby, VJ; Spencer, RL | 2 |
| Burks, TF; Malarchik, ME; Moseberg, HI; Porreca, F; Rivière, PJ; Sheldon, RJ | 1 |
| Hill, JM; Kaufman, MP | 1 |
| Kavaliers, M | 1 |
| Christie, MJ; North, RA; Surprenant, A; Williams, JT | 1 |
| Chen, HT; Louie, DS; Owyang, C | 1 |
| Yaksh, TL | 1 |
| Barnes, PJ; Belvisi, MG; Chung, KF; Jackson, DM | 1 |
| Costa, T; Passarelli, F | 1 |
| Clark, MJ; Medzihradsky, F; Nordby, GL | 1 |
| Herz, A; Millan, MJ; Peter, K; Shippenberg, TS; Stein, C | 1 |
| Alvarado, MC; Bennett, EL; Hruby, VJ; Martinez, JL; Patterson, TA; Rosenzweig, MR; Schulteis, G | 1 |
| Fedynyshyn, JP; Kwiat, G; Lee, NM | 1 |
| Burks, TF; Gehrig, CA; Hruby, VJ; Lemcke, PK; Shook, JE | 1 |
| Jackson, HC; Kitchen, I | 1 |
| Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ | 2 |
| Amiche, M; Delfour, A; Mor, A; Nicolas, P; Sagan, S | 2 |
| Di Chiara, G; Fenu, S; Morelli, M | 1 |
| Fedynyshyn, JP; Lee, NM | 1 |
| Haaseth, RC; Heyman, JS; Mosberg, HI; Porreca, F; Vaught, JL | 1 |
| Cox, BM; McMahon, PN; Werling, LL | 1 |
| Bidlack, JM; Selley, DE | 1 |
| Bueno, L; Gué, M; Junien, JL | 1 |
| Ayres, EA; Burks, TF; Hruby, VJ; Kramer, TH; Lemcke, PK; Toth, G | 1 |
| Ayres, EA; Burks, TF; Kramer, TH; Lemcke, PK | 1 |
| Kaiser, ET; Taylor, JW | 1 |
| Dewey, WL; Singha, AK; Welch, SP | 1 |
| Hruby, VJ; Knapp, RJ; Toth, G; Vaughn, LK; Wan, YP; Yamamura, HI | 1 |
| Kiritsy-Roy, JA; Marson, L; Van Loon, GR | 2 |
| Chavkin, C; Opheim, KE; Wimpey, TL | 1 |
| Hong, EK; Takemori, AE | 1 |
| Bodnar, RJ; Gistrak, MA; Pasternak, GW; Paul, D | 1 |
| Dashwood, MR; Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Bastagli, L; Bernardi, P; Caldarera, CM; Guarnieri, C; Ventura, C | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Koob, GF; Tempel, A; Unterwald, EM; Zukin, RS | 1 |
| Crisp, T; Spanos, LJ; Stafinsky, JL | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Gulya, K; Hawkins, KN; Hruby, VJ; Kazmierski, W; Knapp, RJ; Lui, GK; Pelton, JT; Wan, YP; Yamamura, HI | 1 |
| de Castiglione, R; Guglietta, A; Lazarus, LH; Wilson, WE | 1 |
| Nunan, L; Porreca, F; Sheldon, RJ | 2 |
| Ayres, EA; Burks, TF; Hruby, VJ; Kazmierski, W; Kramer, TH; Shook, JE; Wire, WS | 1 |
| Fujimoto, JM; Roerig, SC | 1 |
| Gintzler, AR; Smolens, I; Xu, H | 1 |
| Han, JS; Sun, SL | 1 |
| Burks, TF; Davis, P; Hruby, VJ; Kramer, TH; Toth, G | 1 |
| Gehrig, CA; Martinez, JL; Weinberger, SB | 1 |
| Garzón, J; Sánchez-Blázquez, P; Ulibarri, I | 1 |
| Han, JS; Han, SP; Lu, Z; Ren, MF; Wang, JF; Wang, XJ | 1 |
| Brown, SR; Cox, BM; Werling, LL | 1 |
| Jacoby, HI; Mathiasen, JR; Raffa, RB | 1 |
| Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F | 1 |
| Gratton, A; Jenck, F; Wise, RA | 1 |
| Jenck, F; Quirion, R; Wise, RA | 1 |
| Burks, TF; Hruby, VJ; Pelton, JT; Shook, JE | 1 |
| Bidlack, JM; O'Malley, WE; Schulz, R | 1 |
| Bowen, WD; Huey, R; Kelemen, M; Stewart, D | 1 |
| Calenco, G; Daugé, V; Delay-Goyet, P; Gacel, G; Morgat, JL; Roques, BP; Seguin, C | 1 |
| Akil, H; Mansour, A; Taylor, L; Watson, SJ | 1 |
| Bidlack, JM | 1 |
| Dashwood, MR; Sykes, RM; Thompson, CS | 1 |
| Codd, EE; Walker, RF | 1 |
| Heyman, JS; Mosberg, HI; Porreca, F | 1 |
| Blackburn, TP; Cowan, A; Rance, MJ | 1 |
| La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 1 |
| Kitchen, I; Yeadon, M | 3 |
| Kitchen, I; McDowell, J | 2 |
| Chang, KJ; Leslie, JB; Russell, RD; Su, YF; Watkins, WD | 2 |
| Smith, CB | 1 |
| Delay-Goyet, P; Gacel, G; Roques, BP; Seguin, C | 1 |
| Burks, TF; Fox, DA | 1 |
| Gioannini, TL; Hiller, JM; Keren, O; Simon, EJ | 1 |
| Mathiasen, JR; Raffa, RB; Vaught, JL | 2 |
| Burks, TF; Heyman, JS; Mosberg, HI; Porreca, F; Williams, CL | 1 |
| Bykov, V; Ofri, D; Rice, KC; Rothman, RB | 1 |
| Bodnar, RJ; Lee, SJ; Pasternak, GW; Williams, CL | 1 |
| Brown, DQ; Mathiasen, JR; Raffa, RB | 1 |
| Brinsfield, KH; Matsumoto, RR; Patrick, RL; Walker, JM | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Cox, BM; Frattali, A; Portoghese, PS; Takemori, AE; Werling, LL | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Rice, KC; Schoffelmeer, AN | 1 |
| Gulya, K; Kovács, GL; Kriván, M; Nyolczas, N | 1 |
| Burks, TF; Hruby, VJ; Kazmierski, W; Lemcke, PK; Shook, JE; Wire, WS | 1 |
| Hruby, VJ; Martinez, JL; Schulteis, G | 1 |
| Heyman, JS; Porreca, F | 1 |
| Blackburn, TP; Cross, AJ; Hille, C; Slater, P | 1 |
| Akil, H; Haaseth, RC; Mansour, A; Mosberg, HI; Ramalingam, K; Woodard, RW | 1 |
| Dunwiddie, TV; Su, MT | 1 |
| Dashwood, MR; Muddle, JR; Spyer, KM | 1 |
| Gulya, K; Hruby, VJ; Pelton, JT; Yamamura, HI | 1 |
| Kirby, GC; McQueen, DS | 1 |
| Burks, TF; Deupree, D; Hruby, V; Hsiao, S; Mosberg, HI; Porreca, F; Spencer, RL | 1 |
| Kastin, AJ; Zadina, JE | 1 |
| Harada, H; Misawa, H; Nozaki, M; Takagi, H; Ueda, H | 1 |
| Burks, TF; Hruby, VJ; Lemcke, PK; Pelton, JT; Porreca, F; Shook, JE | 1 |
| Gulya, K; Hruby, VJ; Kazmierski, W; Lui, GK; Pelton, JT; Yamamura, HI | 1 |
| Bero, LA; Kuhn, CM; Lurie, SN | 1 |
| Chavkin, C; Mailheau, S; Neumaier, JF | 1 |
| Carter, BD; Clark, MJ; Medzihradsky, F | 1 |
| Cowan, A; Mosberg, HI; Omnaas, JR; Porreca, F; Zhu, XZ | 1 |
| Clark, JA; Houghten, R; Pasternak, GW | 1 |
| Holtzman, SG; Ukai, M | 1 |
| Fujiwara, M; Kurahashi, K; Okamoto, T | 1 |
| Bidlack, JM; Selley, DE; Tyler, CB | 1 |
| Li, CH; Suh, HH; Tseng, LF | 1 |
| Delay-Goyet, P; Foucaud, B; Rigaudy, P; Roques, BP; Zajac, JM | 1 |
| Akiyama, K; Gee, KW; Hruby, VJ; Mosberg, HI; Yamamura, HI | 1 |
| Cowan, A; Porreca, F; Zhu, XZ | 1 |
| Burks, TF; Hirning, LD; Hruby, VJ; Hurst, R; Mosberg, HI; Porreca, F | 1 |
| Cotton, R; Kosterlitz, HW; Paterson, SJ; Rance, MJ; Traynor, JR | 1 |
| Duckles, SP; Gehlert, DR; Gulya, K; Hruby, VJ; Mosberg, HI; Wamsley, JK; Yamamura, HI | 1 |
| Dray, A; Nunan, L; Wire, W | 3 |
| Gehlert, DR; Gulya, K; Hruby, VJ; Mosberg, H; Wamsley, JK; Yamamura, HI | 1 |
| Hansen, HA; Mulder, AH; Schoffelmeer, AN; Stoof, JC | 1 |
| Heyman, JS; Koslo, RJ; Mosberg, HI; Porreca, F; Tallarida, RJ | 1 |
| Bidlack, JM; O'Malley, WE | 1 |
| Hill, RG; Hughes, J; Leighton, G; Rodriguez, RE | 1 |
| Clark, JA; Hruby, VJ; Itzhak, Y; Pasternak, GW; Yamamura, HI | 1 |
| Akil, H; Khachaturian, H; Lewis, ME; Mansour, A; Watson, SJ | 2 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN; Wardeh, G | 1 |
| Duffy, P; Kalivas, PW; Latimer, LG | 1 |
| Heyman, JS; Mosberg, HI; Omnaas, JR; Porreca, F; Vaught, JL | 1 |
| Gardner, EL; Vaysse, PJ; Zukin, RS | 1 |
| Leadem, CA; Yagenova, SV | 1 |
| Dickenson, AH; Knox, R; Roques, BP; Sullivan, AF; Zajac, JM | 1 |
| Kazmi, SM; Mishra, RK | 1 |
| Dunwiddie, TV; Johnson, KJ; Proctor, WR | 1 |
| Mathiasen, JR; Vaught, JL | 1 |
| Crippen, GM; Peng, JW; Smellie, AS | 1 |
| Lee, NM; Loh, HH; Roy, S; Zhu, YX | 1 |
| Charpak, S; Dreifuss, JJ; Dubois-Dauphin, M; Raggenbass, M | 1 |
| Bozarth, M; Jenck, F; Wise, RA | 1 |
| Mosberg, HI | 1 |
| Dray, A; Nunan, L | 2 |
| Belleney, J; Fournie-Zaluski, MC; Roques, BP | 1 |
| Burks, TF; Hruby, VJ; Hurst, R; Mosberg, HI; Porreca, F | 1 |
| Holaday, JW; Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 1 |
| Akiyama, K; Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 1 |
| Garzón, J; Sánchez-Blázquez, P | 3 |
| Laorden, ML; Llobell, F | 1 |
| Gulya, K; Kása, P; Szikra, J | 1 |
| Calderon, SN; De Leon, IA; Knapp, RJ; Landsman, R; Malatynska, E; Nagase, H; Rice, K; Santoro, G; Varga, E; Waite, S | 1 |
| Condon, R; Goodman, JB; Johnson, PI; Stellar, JR | 1 |
| Cadet, JL; Elmer, GI; Epstein, CJ; Evans, JL; Ladenheim, B | 1 |
| Chiappinelli, VA; Feng, C; McMahon, LL; Wolf, KM; Yum, L | 1 |
| Archer, S; Bidlack, JM; Jiang, Q; Seyed-Mozaffari, A | 1 |
| Fukushima, N; Hayashi, C; Katayama, T; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Capasso, A; Carnuccio, R; D'Acquisto, F; Iuvone, T | 1 |
| Choi, YS; Kim, YH; Sim, YB; Song, DK; Suh, HW | 1 |
| Hammond, DL; Littell, L; Stewart, PE | 1 |
| Cahill, CM; Sawynok, J; White, TD | 2 |
| Chiba, T; Sasaki, Y | 1 |
| Cheng, PY; Soong, Y; Szeto, HH; Wu, DL | 2 |
| Bachelard, H; Pître, M | 1 |
| Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 2 |
| Chang, KJ; Chung, NN; Lee, PH; Nguyen, TM; Schiller, PW | 1 |
| Jensen, EL; Vogt, BA; Wiley, RG | 1 |
| Fukuda, K; Kato, S; Mori, K; Terasako, K | 1 |
| Endoh, T; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Knapp, RJ; Li, X; Malatynska, E; Roeske, WR; Santoro, G; Waite, S; Wang, Y; Yamamura, HI | 1 |
| Noel, MB; Wise, RA | 1 |
| Hruby, VJ; Porreca, F; Yamamura, HI | 1 |
| Bass, PP; Welch, SP | 1 |
| Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M | 1 |
| Collins, JG; Harada, Y; Kitahata, LM; Nakatani, K; Nishioka, K | 1 |
| Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K | 1 |
| Abbott, FV; Hong, Y | 1 |
| Alsasua, A; Martín, MI; Parra, L; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Collins, JG; Harada, Y; Kitahata, LM; Nakatani, K; Omote, K; Yuge, O | 1 |
| Fukuda, K; Higashida, H; Kato, S; Mori, K; Morikawa, H | 1 |
| Freedman, NJ; Kieffer, BL; Lefkowitz, RJ; Pei, G | 1 |
| Kudernatsch, MB; Schlösser, B; Sutor, B; ten Bruggencate, G | 1 |
| Nicosia, F; Rehder, K; Rocchi, D; Song, P; Zappi, L | 1 |
| Shahabi, NA; Sharp, BM | 1 |
| Fujimoto, JM; Rady, JJ | 1 |
| Kushner, L; Tamir, M | 1 |
| Ableitner, A; Hassan, AH; Herz, A; Stein, C | 1 |
| Devine, DP; Leone, P; Pocock, D; Wise, RA | 1 |
| Baghdoyan, HA; Cronin, A; Keifer, JC; Lydic, R | 1 |
| Ableitner, A | 1 |
| Davis, P; Horvath, R; Hruby, VJ; Lipkowski, AW; Misicka, A; Porreca, F; Yamamura, HI | 3 |
| Paul, D; Tran, JG | 1 |
| Kradel, BK; Monroe, PJ; Smith, DJ; Smith, DL | 1 |
| Crisp, T; Keck, BJ; Stafinsky, JL; Uram, M | 1 |
| Armstead, WM | 1 |
| Klitenick, MA; Wirtshafter, D | 1 |
| Akay, M; Akay, YM; Cheng, P; Szeto, HH | 1 |
| Hinson, JP; Kapas, S; Purbrick, A | 1 |
| Badiani, A; Leone, P; Noel, MB; Stewart, J | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Evans, CJ; Hales, TG; Law, PY; Loh, HH; Piros, ET; Prather, PL | 1 |
| Alarcón, S; Hernández, J; Laorden, ML | 1 |
| Crain, SM; Shen, KF | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 2 |
| Ludbrook, J; Ventura, S | 2 |
| Balboni, G; Bianchi, C; Bryant, SD; D'Angeli, F; Lazarus, LH; Marchetti, P; Salvadori, S | 1 |
| Ananthan, S; Cha, XY; Lai, J; Porreca, F; Rice, KC; Rothman, RB; Xu, H | 1 |
| Evans, AA; Hughes, S; Smith, ME | 1 |
| Alfaro, MJ; Goicoechea, C; Lopez, F; Martin, MI; Ormazabal, MJ | 1 |
| Adams, JU; Li, S; Liu-Chen, LY; Yang, HH | 1 |
| Glick, SD; Herrick-Davis, K; Pearl, SM; Teitler, M | 1 |
| Bidlack, JM; Chung, NN; Dooley, CT; Houghten, RA; Pasternak, GW; Schiller, PW; Wilkes, BC | 1 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Tseng, LF; Xu, JY | 1 |
| Kreek, MJ; Rubenfeld, JM; Unterwald, EM | 1 |
| Kim, YH; Song, DK; Suh, HW; Tseng, LF; Yoo, JS | 1 |
| Everitt, BJ; Phillips, GD; Robbins, TW | 1 |
| Almeida, OF; Shippenberg, TS; Spanagel, R | 1 |
| Kamei, J; Misawa, M; Mizoguchi, H; Nagase, H; Suzuki, T; Yoshiike, M | 1 |
| Johnson, PI; Stellar, JR | 1 |
| Fujimoto, JM; Holmes, BB | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Narita, M; Suzuki, T | 1 |
| Nagasaka, H; Yaksh, TL | 1 |
| Bodnar, RJ; Pasternak, GW; Rossi, GC | 1 |
| Gewiss, M; Goldberg, SR; Marley, RJ; Schindler, CW; Shimosato, K; Thorndike, E | 1 |
| Mignat, C; Wille, U; Ziegler, A | 1 |
| Ichikawa, T; Ikeda, K; Kobayashi, T; Kumanishi, T; Usui, H | 1 |
| Capasso, A; Di Giannuario, A; Domenici, MR; Loizzo, A; Pieretti, S; Sagratella, S; Sorrentino, L | 1 |
| Mitrovic, I; Napier, TC | 1 |
| Fukuda, K; Kato, S; Mori, K | 1 |
| Brodsky, M; Elliott, K; Inturrisi, CE; Jenab, S; Kest, B | 1 |
| Pasternak, GW; Schiller, PW; Standifer, KM; Visconti, LM | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Friederich, P; Hescheler, J; Nürnberg, B; Schultz, G | 1 |
| Castro, MA; Garzón, J; Juarros, JL; Martínez-Peña, Y; Sánchez-Blázquez, P | 1 |
| Madamba, SG; Moore, SD; Schweitzer, P; Siggins, GR | 1 |
| North, RA; Tanaka, E | 1 |
| De Vries, TJ; Jonker, AJ; Mulder, AH; Schoffelmeer, AN; Voorn, P | 1 |
| Abbruscato, TJ; Brownson, EA; Davis, TP; Gillespie, TJ; Hruby, VJ | 1 |
| Garzón, J; Martínez-Peña, Y; Sánchez-Blázquez, P | 2 |
| Jauzac, P; Polastron, J | 1 |
| Collins, KA; Kampine, JP; Tseng, LF | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Chang, SL; Ge, LJ; Harrison, LM; Kastin, AJ; Zadina, JE | 1 |
| Iwai, T; Luay, AE; Niwa, M; Nozaki, M; Tsurumi, K | 1 |
| Kolesnikov, YA; Maccechini, ML; Pasternak, GW | 1 |
| Kameyama, T; Mizutani, M; Ukai, M | 1 |
| Kameyama, T; Mizutani, M; Sasaki, Y; Toyoshi, T; Ukai, M | 1 |
| Maggi, CA; Zagorodnyuk, V | 1 |
| Davis, T; Shah, S; Yoburn, BC | 1 |
| Brent, PJ; Bunn, SJ | 1 |
| Kim, YH; Lim, JS; Song, DK; Suh, HW; Tseng, LF | 1 |
| Miller, RJ; Rhim, H | 1 |
| Chien, CC; Pasternak, GW | 1 |
| Emmerson, PJ; Liu, MR; Medzihradsky, F; Woods, JH | 1 |
| Erikson, LJ; Evans, C; Law, PY; Loh, HH; McGinn, TM; Wick, MJ | 1 |
| Hirokami, M; Matsumoto, M; Saito, H; Togashi, H; Yoshioka, M | 1 |
| Ferri, S; Govoni, P; Murari, G; Pistacchio, E; Romagnoli, C; Spampinato, S; Speroni, E | 1 |
| Bernstein, RN; Bilsky, EJ; Hruby, VJ; Lai, J; Pasternak, GW; Patel, D; Porreca, F | 1 |
| Bilsky, EJ; Davis, P; Horváth, R; Kövér, KE; Lou, BS; Misicka, A; Porreca, F; Qian, X; Shenderovich, MD; Zalewska, T | 1 |
| Bernardi, G; Stefani, A; Surmeier, DJ | 1 |
| Crisp, T; Gordon, TL; Hoskins, DL; Perni, VC; Stafinsky, JL; Uram, M | 1 |
| Law, PY; Prather, PL; Tsai, AW | 1 |
| Coenen, A; Lasoń, W; Przewłocka, B; Przewłocki, R; Van Luijtelaar, G | 1 |
| Das, D; Michael-Titus, AT; Rogers, J | 1 |
| McLoon, SC; Wilcox, GL; Wu, HH | 1 |
| Demura, H; Hotta, M; Imaki, T; Ling, N; Shibasaki, T | 1 |
| Garty, M; Keren, O; Sarne, Y | 1 |
| Bilsky, EJ; Lai, J; Porreca, F; Rothman, RB | 1 |
| Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Venier, I | 1 |
| Glaum, SR; Miller, RJ; Rhim, H | 1 |
| Graeser, D; Neubig, RR | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Carter, BD; Medzihradsky, F | 1 |
| Han, JS; Ren, MF; Wang, JF; Xue, JC | 1 |
| North, RA; Sugita, S | 1 |
| Adamo, EB; Di Giovanni, G; Marini, R; Mulè, F; Postorino, A; Serio, R | 1 |
| Hruby, VJ | 1 |
| Kaneko, S; Katao, Y; Maekawa, K; Minami, M; Nakamura, S; Onogi, T; Satoh, M; Toya, T | 1 |
| Castro, MA; Garzón, J; Juarros, JL; Sánchez-Blázquez, P | 1 |
| D'Alecy, LG; Mayfield, KP | 1 |
| Christinck, F; Cipris, S; Daniel, EE; Fox-Threlkeld, JE; Hruby, VJ; Woskowska, Z | 1 |
| Hammond, DL; Stewart, PE | 2 |
| Fang, L; Haaseth, RC; Horvath, R; Hruby, VJ; Knapp, RJ; Matsunaga, TO; Porreca, F; Yamamura, HI | 1 |
| Adler, MW; Geller, EB; Handler, CM; Piliero, TC | 1 |
| De Lander, GE; Keil, GJ | 1 |
| Amodeo, P; Bianchi, C; Guerrini, R; Lazarus, LH; Picone, D; Salvadori, S; Tancredi, T; Temussi, PA; Tomatis, R | 1 |
| Grudt, TJ; Williams, JT | 1 |
| Maier, SF; Mooney-Heiberger, K; Watkins, LR; Wiertelak, EP; Yang, HY | 1 |
| Martin, BR; Smith, PB; Welch, SP | 1 |
| Baumeister, AA; Chaney, TM; Curtis, W; Hurry, M; Leoni, RR; Wolf, E | 1 |
| Hirokami, M; Ikeda, T; Matsumoto, M; Saito, H; Smith, CB; Tochihara, M; Togashi, H; Yoshioka, M | 1 |
| Haaseth, RC; Hruby, VJ; Matsunaga, TO; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Vanderah, T | 1 |
| Devine, DP; Wise, RA | 1 |
| Brown, GP; Chien, CC; Pasternak, GW; Standifer, KM; Wahlestedt, C | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Higuchi, H; Kuo, CH; Miki, N; Nakano, K; Osugi, T | 1 |
| Brown, G; Chien, CC; Pan, YX; Pasternak, GW | 1 |
| Costentin, J; Dourmap, N | 1 |
| Bilsky, EJ; Davis, P; Davis, TP; Haaseth, RC; Horan, PJ; Porreca, F; Slaninova, J; Weber, SJ; Yamamura, HI; Zalewska, T | 1 |
| Hasegawa, A; Nagamatsu, K; Tagawa, Y; Uchida, S | 1 |
| Orzi, F; Passarelli, F | 1 |
| Sun, X | 1 |
| Collins, KA; Lin, JJ; Tseng, LF | 1 |
| Fukushima, N; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Dworkin, SI; Martin, TJ; Smith, JE | 1 |
| Breivogel, CS; Childers, SR; Selley, DE | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
| Collins, N; Hruby, VJ; Matsunaga, TO; O'Brien, DF; Ramaswami, V; Yamamura, SH | 1 |
| Carlezon, WA; Devine, DP; Leone, P; Wise, RA | 1 |
| Chang, KJ; Comer, SD; De Costa, BR; Hoenicke, EM; McNutt, RW; Mosberg, HI; Sable, AI; Woods, JH | 1 |
| Chakrabarti, S; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Beatty, MF; Casy, AF; Kamal, JJ; Loew, GH; Maguire, PA; Perez, JJ; Rodriguez, L; Tsai, NF; Upton, C; Villar, HO | 1 |
| Durham, RA; Lookingland, KJ; Manzanares, J; Moore, KE | 1 |
| Aloyo, VJ; Battisi, WP; Pazdalski, PS | 1 |
| Parenti, C; Scoto, GM | 1 |
| Capogna, M; Gähwiler, BH; Thompson, SM | 1 |
| Búzás, B; Cox, BM; Izenwasser, S; Portoghese, PS | 1 |
| Cote, TE; Cox, BM; Izenwasser, S; Kreek, MJ; Unterwald, EM | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H | 1 |
| Barg, J; Belcheva, M; Coscia, CJ; Levy, R; McHale, R; Vogel, Z | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Bowen, WD; Carlisi, VJ; Hruby, VJ; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Wild, KD | 1 |
| Laugwitz, KL; Offermanns, S; Schultz, G; Spicher, K | 1 |
| Bhargava, HN; Rahmani, NH | 1 |
| Kameyama, T; Mori, E; Ukai, M | 1 |
| Bültmann, R; Driessen, B; Starke, K; von Kügelgen, I | 1 |
| German, DC; Manaye, KF; Sadeq, M; Speciale, SG | 1 |
| Loh, HH; Seybold, VS; Tao, PL | 1 |
| Dhar, MM; Mazumder, S; Nath, I | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Agarwal, D; Glasel, JA | 1 |
| Baumhaker, Y; Goldstein, MN; Sarne, Y; Wollman, Y | 1 |
| Han, JS; Ren, MF; Shun, XJ; Wang, JF; Yang, HF | 1 |
| Welch, SP | 1 |
| Bakshi, VP; Kelley, AE | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Meyer, ME | 1 |
| Fan, LQ; Gioannini, TL; Hiller, JM; Hyde, L; Ofri, D; Simon, EJ; Yao, YH | 1 |
| Matsumoto, M; Saito, H; Smith, CB; Togashi, H; Yoshioka, M | 1 |
| Bourne, RC; Csillag, A; Maglóczky, Z; Steele, RJ; Stewart, MG; Székely, AD | 1 |
| Cotter, P; Deviche, P; Gulledge, CC | 1 |
| Borsodi, A; Haaseth, RC; Horan, PJ; Hruby, VJ; Lipkowski, A; Matsunaga, TO; Misicka, A; Toth, G; Wild, KD; Yamamura, HI | 1 |
| North, RA; Piguet, P | 1 |
| Burks, TF; Davis, P; Hruby, VJ; Kramer, TH; Porreca, F | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Gomathi, KG; Sharma, SK | 1 |
| Cabon, F; Morser, J; Parmantier, E; Pham-Dinh, D; Solly, SK; Zalc, B | 1 |
| Cheng, PY; Decena, JA; McCabe, S; Soong, Y; Szeto, HH; Wu, D | 1 |
| Adams, JU; Adler, MW; Geller, EB; Tallarida, RJ | 1 |
| Aloyo, VJ; Harvey, JA; Romano, AG | 1 |
| Ho, IK; Hoskins, B; Jaw, SP | 1 |
| Chang, YS; Gage, DA; Watson, JT | 1 |
| Goñalons, E; Jiménez, M; Martínez, V; Vergara, P | 1 |
| Hong, M; Jhamandas, K; Sutak, M | 1 |
| Gehrig, CA; Hruby, VJ; Nikiforovich, GV; Prakash, OM | 1 |
| Abood, ME; Pugh, G; Welch, SP | 1 |
| Han, JS; Kang, HG; Li, CQ; Liu, NJ; Xu, C; Xu, T; Yu, YX | 1 |
| García-España, A; Garzón, J; Sánchez-Blázquez, P | 2 |
| Borgbjerg, FM; Frigast, C; Madsen, JB; Mikkelsen, LF | 1 |
| Choi, YS; Kim, YH; Song, DK; Suh, HW | 1 |
| Haney, M; Miczek, KA | 1 |
| Hirst, RA; Lambert, DG | 1 |
| Danzebrink, RM; Gebhart, GF; Green, SA | 1 |
| Chaplan, SR; Lee, YW; Yaksh, TL | 1 |
| Hruby, VJ; Jiao, D; Kövér, KE; Nikiforovich, GV; Shenderovich, MD | 1 |
| Lomize, AL; Mosberg, HI; Pogozheva, ID | 2 |
| Cai, Y; Pei, G; Wu, Y; Zhang, Y | 1 |
| Bernstein, RN; Bilsky, EJ; Hruby, VJ; Lai, J; Porreca, F; Rothman, RB | 1 |
| Lambert, DG; Smart, D | 1 |
| Morgan, EL | 1 |
| Carbone, E; Cesare, P; Clementi, F; Codignola, A; Magnelli, V; Pollo, A; Sher, E; Tarroni, P | 1 |
| Hruby, VJ; Kovelowski, CJ; Nichols, ML; Ossipov, MH; Porreca, F | 1 |
| Amoroso, D; Catozzi, L; Ceppi, E; Groppetti, A; Guglielmetti, F; Palazzi, E | 1 |
| Barg, J; Belcheva, MM; Coscia, CJ; Ho, MT; Ignatova, EG; Jefcoat, LB; Johnson, FE; McHale, RJ; Vogel, Z | 1 |
| Abbruscato, TJ; Bartosz, H; Davis, TP; Gillespie, TJ; Greene, DL; Hau, VS; Hom, S; Hruby, VJ; Lipkowski, AW; Misicka, A | 1 |
| Davis, P; Frycia, A; Hruby, VJ; Jaspers, H; Porreca, F; Toth, G; Tourwé, D; Van Binst, G; Verheyden, P; Verschueren, K | 1 |
| Endoh, T; Suzuki, T | 2 |
| Burks, TF; Hruby, VJ; Roerig, SC; Rosenfeld, GC; Williams, CL | 1 |
| Avidor-Reiss, T; Levy, R; Nevo, I; Pfeuffer, T; Vogel, Z | 1 |
| Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Clarke, IJ; Walsh, JP | 1 |
| Abbruscato, TJ; Davis, TP; Hruby, VJ; Williams, SA | 1 |
| Potter, DE; Wang, D | 1 |
| Mokha, SS; Wang, XM; Zhang, KM | 1 |
| Lysle, DT; Schneider, GM | 2 |
| Chang, KJ; Li, LY | 1 |
| Bhargava, HN; Zhao, GM | 3 |
| Mendella, PD; Zacharko, RM | 1 |
| Bailey, EC; Bruce, DS; Hellgren, EC; Horton, ND; Jacobson, D; Oeltgen, PR; Setran, DP; Tramell, MS | 1 |
| Chen, C; Pollack, GM | 5 |
| Honkanen, A; Hyytiä, P; Korpi, ER; Sarviharju, M; Vilamo, L; Wegelius, K | 1 |
| Gouardères, C; Jhamandas, K; Sutak, M; Zajac, JM | 1 |
| Cox, BM; Noble, F | 1 |
| Kow, LM; Pfaff, DW; Zhang, C | 1 |
| Haaseth, RC; Hruby, VJ; Lipkowski, AW; Misicka, A; O'Brien, DF; Ramaswami, V; Romanowski, M; Zhu, X | 1 |
| Kar, S; Ménard, DP; Quirion, R; van Rossum, D | 1 |
| Cox, BM; Heller, B; Izenwasser, S | 1 |
| Bronson, JB; Chen, DY; Koob, GF; Motis, V; Vankova, ME; Weinger, MB | 1 |
| Casares, F; Liu, U; Stefano, GB | 1 |
| Audet, RM; Butterworth, RF; de Waele, JP; Leong, DK | 1 |
| Burke, T; Lewis, JW; Woods, JH; Zernig, G | 1 |
| Hruby, VJ; Liao, S; Qian, X; Stropova, D; Yamamura, HI | 1 |
| Gao, P | 1 |
| Belknap, JK; Grandy, DK; Grisel, JE; Mogil, JS; Zhangs, G | 1 |
| Christensen, CB; Christrup, LL; Kristensen, K; Nielsen, LC | 1 |
| Bot, G; Chahl, LA | 1 |
| Franck, J; Nylander, I; Rosén, A | 1 |
| Mokha, SS; Wang, XM | 1 |
| Blake, DR; Earl, JR; Grootveld, MC; Morris, CJ | 1 |
| Hanke, J; Jaros, PP; Willig, A | 1 |
| Deviche, P; Ebbesson, LO; Ebbesson, SO | 1 |
| Jewett, DC; Mosberg, HI; Woods, JH | 1 |
| Choi, SR; Kim, YH; Lee, KJ; Song, DK; Suh, HW | 1 |
| Kaputlu, I; Oğütman, C; Sadan, G | 1 |
| Castanas, E; Hatzoglou, A; Kampa, M; Loukas, S; Martin, P; Martin, PM | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Choi, SR; Chung, KM; Kim, YH; Song, DK; Suh, HW | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Demedts, MG; Dupont, LJ; Pype, JL; Verleden, GM | 1 |
| Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM | 1 |
| Mokha, SS; Wang, XM; Yan, JQ; Zhang, KM | 1 |
| Yuan, CS | 1 |
| Bhargava, HN; Bian, JT | 1 |
| Bharagava, HN; Zhao, GM | 1 |
| Duvauchelle, CL; Fleming, SM; Kornetsky, C | 2 |
| Obermeier, H; Schulz, R; Wehmeyer, A | 1 |
| Miftakhov, RN; Wingate, DL | 1 |
| Loew, GH; Maguire, PA | 1 |
| Kamei, J; Kawai, K; Mizoguchi, H; Mizusuna, A; Nagase, H; Narita, M; Suzuki, T; Tseng, LF | 1 |
| Ikeda, H; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Peter, Y; Pick, CG; Schreiber, S; Weizman, R | 1 |
| Fujimoto, J; Ho, BY; Holmes, BB; Zhao, J | 1 |
| Cai, YC; Cheng, ZJ; Fan, GH; Jiang, LZ; Ma, L; Pei, G | 1 |
| Cui, Y; Lee, TF; Wang, LC; Westly, J | 1 |
| Taglietti, V; Toselli, M; Tosetti, P | 2 |
| Choi, YS; Kim, YH; Song, DK; Suh, HW; Tseng, LF; Yoo, JS | 1 |
| Nelson, WL; Palmer, RB; Upthagrove, AL | 1 |
| Archer, S; Bidlack, JM; McLaughlin, JP; Sebastian, A | 1 |
| Abbruscato, TJ; Davis, TP; Hruby, VJ; Thomas, SA | 1 |
| Bodnar, RJ; Ruegg, H; Yu, WZ | 1 |
| Pepin, MC; Roberts, E; Wahlestedt, C; Walker, P; Yue, SY | 1 |
| Schulz, R; Wehmeyer, A | 1 |
| Darula, Z; Fürst, S; Gyires, K; Rónai, AZ; Tóth, G | 1 |
| Soong, Y; Szeto, HH; Taylor, CC; Wu, D; Yee, JS | 1 |
| Caudle, RM; Dubner, R; Ho, J; Mannes, AJ | 1 |
| Bhargava, HN; Cao, YJ; Zhao, GM | 2 |
| Bhargava, HN; Cao, YJ | 4 |
| Cai, YC; Fan, GH; Jiang, LZ; Ma, L; Pei, G; Zhao, J | 1 |
| Khan, S; Smith, ME | 1 |
| Bonner, GG; Davis, P; Ferguson, R; Hruby, VJ; Porreca, F; Stropova, D; Yamamura, HI | 1 |
| Cheng, Z; Pei, G; Wang, C; Wu, Y; Zhou, D; Zhu, X | 1 |
| Leventhal, L; Pasternak, GW; Rossi, GC; Su, H; Su, W | 1 |
| Lattanzi, R; Melchiorri, P; Negri, L; Potenza, RL; Severini, C | 1 |
| Kishimoto, Y; Maeda, J; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Beck, HI; Chan, JS; Wong, YH | 1 |
| Connor, MA; Henderson, G; Keir, MJ | 1 |
| Funada, M; Sora, I; Uhl, GR | 1 |
| Bodnar, RJ; Yu, WZ | 1 |
| Ho, MK; Wong, YH | 1 |
| DiGiacomo, B; Larson, DL; Ohkawa, S; Portoghese, PS; Takemori, AE | 1 |
| Carabelli, V; Carbone, E; Lovallo, M; Magnelli, V; Zucker, H | 1 |
| Burkey, TH; Hosohata, K; Hosohata, Y; Hruby, VJ; Knapp, RJ; Nagase, H; Porreca, F; Quock, RM; Rice, KC; Roeske, WR; Yamamura, HI; Zhang, X | 1 |
| Kuraishi, Y; Tohda, C; Yamaguchi, T | 1 |
| Nicosia, F; Nicosia, S; Rehder, K; Song, P; Zappi, L | 1 |
| Bauer, L; Bhargava, HN; Bian, JT; Dunn, WJ; Nan, Y; Upadhyaya, SP; Xu, W; Zhao, GM | 1 |
| Kavaliers, M; Ossenkopp, KP; Prato, FS; Thomas, AW | 2 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Kramer, TH; Porreca, F | 1 |
| Ho, MK; Joshi, S; Tsu, RC; Wong, YH; Yung, LY | 1 |
| Chakrabarti, S; Law, PY; Loh, HH; Yang, W | 1 |
| Lou, LG; Pei, G | 1 |
| Bandler, R; Christie, MJ; Crowfoot, LJ; Floyd, NS; Henderson, LA; Keay, KA | 1 |
| Chen, C; Li, JG; Liu-Chen, LY; Luo, LY; Zhu, J | 1 |
| Labuz, D; Machelska, H; Przewłocka, B; Przewłocki, R | 1 |
| Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
| Cavagnero, S; Davis, P; Horvath, R; Hruby, VJ; Misicka, A; Porreca, F; Yamamura, HI | 1 |
| Rothe, KS; Stevens, CW | 1 |
| Kelley, AE; Zhang, M | 1 |
| Balboni, G; Bianchi, C; Bryant, SD; Cooper, PS; Guerrini, R; Lazarus, LH; Salvadori, S; Tomatis, R | 1 |
| Eriksson, PS; Hansson, E; Ronnback, L; Thorlin, T | 2 |
| Bolling, SF; Harlow, HH; Kilgore, KS; Oeltgen, PR; Su, TP; Tramontini, NL | 1 |
| Davis, P; Haaseth, RC; Hruby, VJ; Porreca, F; Yamamura, HI; Zalewska, T | 1 |
| Chen, C; Jeffery, D; Jorgenson, JW; Moseley, MA; Pollack, GM | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Akil, H; Clark, MJ; Emmerson, PJ; Mansour, A; Medzihradsky, F; Portoghese, PS; Remmers, AE; Woods, JH | 1 |
| Beacham, DW; Bunzow, JR; Cook, SP; Grandy, DK; Nah, SY; Unteutsch, A | 1 |
| Bhargava, HN; Bian, JT; Cao, YJ | 1 |
| Hammond, DL; Thorat, SN | 1 |
| Inturrisi, CE; Kao, B; Kest, B; McLemore, G | 1 |
| Szekeres, PG; Traynor, JR | 1 |
| Grandy, DK; Murray, TF; Zhang, G | 1 |
| Kameyama, T; Sasaki, Y; Takada, A; Ukai, M | 1 |
| Lin, M; Petersheim, M; Rinaldi, F; Shapiro, MJ | 1 |
| Basbaum, AI; Hammond, DL; Nakashima, N; Wang, H | 1 |
| Bhargava, HN; Cortijo, J; Morcillo, EJ; Villar, VM | 1 |
| Bhargava, HN; Bian, JT; Kumar, S | 1 |
| Lishmanov, IuB; Maslov, LN; Ugdyzhekova, DS | 1 |
| Calò, L; Carmenini, E; Orzi, F; Passarelli, F; Pontieri, FE | 1 |
| Avidor-Reiss, T; Barg, J; Belcheva, MM; Coscia, CJ; Ignatova, E; Levy, R; Vogel, Z; Young, EC; Zippel, R | 1 |
| Jain, S; Kolesnikov, Y; Pasternak, GW; Wilson, R | 1 |
| Herlenius, EA; Lindahl, SG; Takita, K; Yamamoto, Y | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Hauser, KF; Stiene-Martin, A; Zhou, R | 1 |
| Clapp, JF; Kett, A; Kim, H; Olariu, N; Omoniyi, AT; Szeto, HH; Wu, D | 1 |
| Bardin, M; Bourget, P; Caussade, F; Coudore, F; Courteix, C; Eschalier, A; Fialip, J | 1 |
| Fan, GH; Pei, G; Zhang, WB; Zhou, TH | 1 |
| Fan, GH; Jing, Q; Lou, LG; Ma, L; Pei, G; Wu, YL; Zhang, Z; Zhao, J | 1 |
| Broccardo, M; Improta, G; Tabacco, A | 1 |
| Pierau, FK; Sann, H; Yakimova, KS | 1 |
| Choudhury, K; Eriksson, PS; Hansson, E; Nilsson, M; Roginski, RS; Rönnbäck, L; Thorlin, T | 1 |
| Miller, RJ; Simen, AA | 1 |
| Chan, JS; Joshi, S; Lee, JW; Wong, YH | 1 |
| Carney, JM; Harris-White, ME; Hauser, KF; Jackson, JA; Opanashuk, LA | 1 |
| Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W | 1 |
| Garzón, J; Rodríguez-Díaz, M; Sánchez-Blázquez, P | 1 |
| Inturrisi, CE; Jenab, S; Kao, B; Kest, B; Lee, CE | 1 |
| Fields, A; Gafni, M; Rubovitch, V; Sarne, Y | 1 |
| Liu, HC; Loh, HH; Roy, S | 1 |
| Devi, LA; Hirst, RA; Lambert, DG; Smart, D | 1 |
| Law, PY; Loh, HH; Strassheim, D | 1 |
| He, L; Lee, NM | 1 |
| Avram, D; Bouvier, C; Hettinger, B; Leid, M; Murray, TF; Peterson, VJ; Soderstrom, K | 1 |
| Carabelli, V; Carbone, E; Carra, I | 1 |
| Carbone, E; Clementi, F; Codignola, A; Missale, C; Sher, E; Spano, P | 1 |
| Aberg, ND; Eriksson, PS; Hansson, E; Persson, PA; Rönnbäck, L; Thorlin, T | 1 |
| Herlenius, E; Lindahl, SG; Takita, K; Yamamoto, Y | 1 |
| Aynsley-Green, A; Dashwood, MR; Dickenson, AH; Fitzgerald, M; Rahman, W | 1 |
| Calderon, SN; Krassnig, R; Lai, J; Matecka, D; Ni, Q; Partilla, JS; Porreca, F; Rice, KC; Rothman, RB; Schmidhammer, H; Xu, H | 1 |
| Nozaki-Taguchi, N; Yamamoto, T | 1 |
| Fukuda, K; Kato, S; Mima, H; Mori, K; Morikawa, H; Shoda, T | 1 |
| Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G | 1 |
| Chen, J; Cheng, Z; Chi, Z; Li, G; Pei, G; Wang, C; Wei, Q; Zhou, D | 1 |
| Kamei, J | 1 |
| Cheng, ZJ; Ma, L; Pei, G; Wu, YL; Yu, QM | 1 |
| Beczkowska, I; Franklin, SO; Inturrisi, CE; Kest, B; Lee, CE; Mogil, JS | 1 |
| Lupica, CR; Svoboda, KR | 1 |
| Boudinot, E; Denavit-Saubié, M; Foutz, AS; Kieffer, BL; Maldonado, R; Matthes, HW; Negri, L; Roques, BP; Severini, C; Smadja, C; Valverde, O; Vonesch, JL | 1 |
| Bakota, L; Gulya, K; Szikra, J; Toth, G | 1 |
| Clark, MJ; Liu, XY; Medzihradsky, F; Remmers, AE | 1 |
| Miczek, KA; Vivian, JA | 1 |
| Abbruscato, TJ; Davis, TP; Egleton, RD; Thomas, SA | 1 |
| Yuan, XR | 1 |
| Abdulla, FA; Smith, PA | 1 |
| Gilmore, DP; Wilson, CA; Yilmaz, B | 1 |
| Hebb, AL; Maddeaux, C; Marsh, NJ; Mendella, PD; Zacharko, RM | 1 |
| Belcheva, MM; Bohn, LM; Coscia, CJ; Ignatova, EG; Neuman, MC | 1 |
| Adams, CE; Lupica, CR; Svoboda, KR | 1 |
| Aghajanian, GK; Marek, GJ | 1 |
| Finberg, RW; Heagy, W; Lopez, P; Teng, E | 1 |
| Fujimoto, JM; Gorny, JM; Rady, JJ | 1 |
| Burger, K; Chung, NN; Schiller, PW; Sewald, N; Winkler, D | 1 |
| Castanas, E; Denizot, A; Dermitzaki, I; Gravanis, A; Hatzoglou, A; Henry, JF; Kampa, M; Margioris, AN; Oliver, C | 1 |
| Abramić, M; Balog, T; Hrsak, I; Marotti, T; Svoboda-Beusen, I | 1 |
| Holtzman, SG; Waddell, AB | 1 |
| Laferrière, A; Liu, JK; Moss, IR | 1 |
| Deviche, P; Gulledge, CC | 1 |
| Allen, RG; Fujimoto, KI; Nelson, CS; Pellegrino, MJ; Sirianni, MJ | 1 |
| Eriksson, PS; Hansson, E; Persson, PA; Rönnbäck, L; Thorlin, T | 1 |
| Joshi, S; Lee, JW; Wong, YH | 1 |
| Fuchs, PN; Raja, SN; Roza, C; Sora, I; Uhl, G | 1 |
| DeAntonio, I; DeFelipe, J; García-España, A; Garzón, J; Rodríguez, JR; Sánchez-Blázquez, P | 1 |
| Chen, J; Chi, ZQ; Li, GE; Pei, G; Wang, CH; Zhou, DH | 1 |
| Chang, A; King, M; Pasternak, GW | 1 |
| Alfaro, MJ; Goicoechea, C; Martín, MI; Ormazábal, MJ | 1 |
| Mizoguchi, H; Narita, M; Sora, I; Tseng, LF; Uhl, GR | 1 |
| Coirini, H; Ortí, E; Pico, JC | 1 |
| Murphy, J; Schulz, K; Schulz, R; Wehmeyer, A | 1 |
| El Kouhen, R; Kouhen, OM; Law, PY; Loh, HH | 1 |
| Clapp, JF; Kett, A; Kim, H; Olariu, N; Soong, Y; Szeto, HH; Wu, D | 1 |
| Kowalski, J | 2 |
| Davis, TP; Egleton, RD | 1 |
| Albrecht, E; Berger, H; Bienert, M; Wallukat, G | 1 |
| Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ | 1 |
| Dickenson, AH; Rahman, W | 1 |
| Abbruscato, TJ; Davis, TP | 1 |
| Grabow, TS; Hammond, DL; Hurley, RW; Tallarida, RJ | 1 |
| Foss, JF; Yuan, CS | 1 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Malatynska, E; Porreca, F; Slaninova, J; Stropova, D; Yamamura, HI | 1 |
| Christie, MJ; Connor, M; Pintar, JE; Schuller, A | 1 |
| Fisone, G; Fredholm, B; Greengard, P; Lindskog, M; Svenningsson, P | 1 |
| Környei, JL; Kovács, KA; Oszter, A; Rao, CV; Vértes, M; Vértes, Z | 1 |
| Allouche, S; Jauzac, P; Marie, N; Roussel, M | 1 |
| Cooper, AJ; Stanford, IM | 1 |
| Benjamin, D; Pohorecky, LA; Rice, KC; Skiandos, A; Zhang, X | 1 |
| Garzón, J; Pol, O; Puig, MM; Sánchez-Blázquez, P; Valle, L | 1 |
| Ingenito, AJ; Shen, S | 1 |
| Carroll, J; Chen, B; Duttaroy, A; Sehba, F; Shah, S; Shen, J; Yoburn, BC | 1 |
| Higashi, H; Kohno, T; Kumamoto, E; Shimoji, K; Yoshimura, M | 1 |
| Dickenson, A; Fitzgerald, M; Hatch, D; Marsh, D | 2 |
| Ben, LH; Luo, SQ; Pei, G; Xin, SM; Zhao, J | 1 |
| Allouche, S; Hasbi, A; Homburger, V; Jauzac, P; Polastron, J | 1 |
| Appleyard, SM; Celver, J; Chavkin, C; Kovoor, A; Pineda, V; Wayman, GA | 1 |
| Gomes, I; Gupta, A; Sharma, SK; Singh, SP | 1 |
| McGinty, JF; Rawls, SM; Terrian, DM | 1 |
| Babey, AM; Cavalli, A; Loh, HH | 1 |
| Acosta, CG; López, HS | 1 |
| Ma, L; Pei, G; Wu, GX; Xin, SM; Zhang, WB; Zhang, Z | 1 |
| Alfaro-Lopez, J; Burkey, TH; Hosohata, K; Hruby, VJ; Roeske, WR; Yamamura, HI | 1 |
| Banks, WA; Brown, TT; Kastin, AJ; Maresh, GA; Zadina, JE | 1 |
| Gafni, M; Keren, O; Sarne, Y | 1 |
| Abbruscato, TJ; Bechowski, HB; Davis, TP; Egleton, RD; Gentry, CL; Gillespie, T; Hruby, VJ | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Burkey, TH; Hosohata, Y; Hruby, VJ; Kovelowski, CJ; Lai, J; Ossipov, MH; Porreca, F; Rice, KC; Roeske, WR; Sora, I; Uhl, GR; Vanderah, TW; Yamamura, HI; Zhang, X | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Beslot, F; Ledent, C; Parmentier, M; Roques, BP; Valverde, O | 1 |
| Elde, RP; Hauser, KF; Houdi, AA; Maxson, W; Turbek, CS | 1 |
| Endo, K; Yawo, H | 1 |
| Freeman, FM; Young, IG | 1 |
| Bereiter, DA; Hirata, H; Hu, JW; Takeshita, S | 1 |
| Campbell, WB; Fujimoto, JM; Rady, JJ | 1 |
| Chen, ZW; Han, JS; Wang, Y; Yang, K | 1 |
| Gyires, K; Rónai, AZ | 1 |
| Hruby, VJ; Kim, K; O'Brien, DF; Romanowski, M; Zhu, X | 1 |
| Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB | 1 |
| Davis, TP; Egleton, RD; Huber, JD; Witt, KA | 1 |
| Hong, X; Lin, B; Wang, C; Zhao, X | 1 |
| Gross, GJ; Krylatov, AV; Lasukova, TV; Lishmanov, YB; Maslov, LN; Stefano, GB | 1 |
| Goodman, M; Malkmus, S; Rew, Y; Schiller, PW; Svensson, CI; Taulane, JP; Yaksh, TL | 1 |
| Boguslavsky, V; Hruby, VJ; Lipkowski, AW; Misicka, A; O'Brien, DF | 1 |
| Bogacka, I; Kaminski, T; Okrasa, S; Przala, J; Siawrys, G | 1 |
| Gross, GJ; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stefano, GB; Tam, SW | 1 |
| Bogacka, I; Kaminski, T; Okrasa, S; Przala, J; Siawrys, C | 1 |
| Bouryi, VA; Lewis, DI | 1 |
| Bespalova, ZhD; Lasukova, TV; Maslov, LN; Nagase, H; Oldgen, P; Rice, KK | 1 |
| Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K | 1 |
| Balboni, G; Jutkiewicz, EM; Mosberg, HI; Torregrossa, MM; Watson, SJ; Woods, JH | 1 |
| Baugh, MM; Bradford, CS; Moore, FL; Stanley, DJ; Walthers, EA | 1 |
| Kang-Park, MH; Kieffer, BL; Moore, SD; Roberts, AJ; Siggins, GR | 1 |
| Filizola, M; Negri, A; Provasi, D; Scarabelli, G | 1 |
| Abbruscato, TJ; Islam, MR; Karamyan, VT; Yang, L | 1 |
| Carradori, S; Hruby, VJ; Lei, W; Luisi, G; Macedonio, G; Mollica, A; Stefanucci, A; Streicher, JM | 1 |
| Feeney, C; Kristal, MB; Thompson, AC | 1 |
3 review(s) available for enkephalin, d-penicillamine (2,5)- and enkephalin, leucine
| Article | Year |
|---|---|
Molecular organization of receptors. Efficacy, agonists, and antagonists.
Topics: Amino Acid Sequence; Animals; Drug Design; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Neuropeptides; Receptors, Cell Surface; Receptors, Neurotransmitter; Signal Transduction | 1995 |
Conformational and topographical considerations in the design of biologically active peptides.
Topics: Amino Acid Sequence; Amino Acids; Drug Design; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Oxytocin; Peptides; Peptides, Cyclic; Protein Conformation; Protein Structure, Secondary; Receptors, Opioid, delta; Somatostatin; Structure-Activity Relationship | 1993 |
[Mechanisms of central antitussives].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antitussive Agents; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GABA-B Receptor Agonists; Humans; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin Receptor Agonists | 1998 |
906 other study(ies) available for enkephalin, d-penicillamine (2,5)- and enkephalin, leucine
| Article | Year |
|---|---|
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Narcotic Antagonists; Potassium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance P; Trigeminal Nuclei | 1992 |
Pre- and postsynaptic inhibition by opioids in rat striatum.
Topics: Action Potentials; Animals; Corpus Striatum; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Male; Membrane Potentials; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synapses | 1992 |
Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Morphine; Morphine Derivatives; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Subcellular Fractions | 1992 |
Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype.
Topics: Affinity Labels; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Spinal Cord; Thiocyanates | 1992 |
Effects of [D-Ala2, D-Leu5]enkephalin and [D-Pen2, L-Pen5]enkephalin on apomorphine-induced motor activity in the mouse.
Topics: Analgesics; Animals; Apomorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Grooming; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1992 |
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil | 1992 |
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach | 1992 |
Synthesis and binding characteristics of the highly delta-specific new tritiated opioid peptide, [3H]deltorphin II.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indicators and Reagents; Isotope Labeling; Kinetics; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1992 |
Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.
Topics: Analgesics; beta-Endorphin; Cell Survival; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; Indoles; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Studies on the effects of glucose in vitro and of the glycaemic state in vivo on the binding characteristics of mu, delta and kappa opiate receptors in mouse brain.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucose; Ligands; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Streptozocin | 1992 |
Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity.
Topics: Analgesics; Animals; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
The tail-flick inhibition induced by beta-endorphin administered intrathecally is mediated by activation of kappa- and mu-opioid receptors in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Methysergide; Mice; Mice, Inbred ICR; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yohimbine | 1992 |
Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Analgesics; Animals; Autoradiography; Cell Line; Cell Membrane; Cholera Toxin; Electrophoresis, Polyacrylamide Gel; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Kinetics; Mice; Molecular Weight; Neuroblastoma; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1992 |
Opioid peptides reduce synaptic transmission in the nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Naloxone; Neurons; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synapses; Synaptic Transmission | 1992 |
Antinociceptive and motor effects of delta/mu and kappa/mu combinations of intrathecal opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Motor Activity; Nociceptors; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Delta and kappa opiate receptors in primary astroglial cultures. Part II: Receptor sets in cultures from various brain regions and interactions with beta-receptor activated cyclic AMP.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Animals; Astrocytes; Brain Stem; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Isoproterenol; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes | 1992 |
Dopamine depletion produces augmented behavioral responses to a mu-, but not a delta-opioid receptor agonist in the nucleus accumbens: lack of a role for receptor upregulation.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Iodine Radioisotopes; Male; Microinjections; Narcotics; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Up-Regulation | 1992 |
Streptozotocin-induced diabetes selectively alters the potency of analgesia produced by mu-opioid agonists, but not by delta- and kappa-opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Ventricles; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
[Activation of delta-opiate receptor simultaneously stimulates ACTH beta-endorphin and prolactin release].
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological | 1992 |
Characterization of beta-125I-endorphin cross-linked proteins in NG108-15 cell membranes. A 25-kilodalton protein with properties of delta-opioid-binding site.
Topics: 3T3 Cells; Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cross-Linking Reagents; Down-Regulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Membrane Proteins; Mice; PC12 Cells; Peptides; Receptors, Opioid | 1992 |
Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity.
Topics: Amino Acid Sequence; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Molecular Sequence Data; Protein Conformation; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Substrate Specificity; Tyrosine | 1992 |
Identification and characterization of delta opioid binding sites in the bovine pineal.
Topics: Analgesics; Animals; beta-Endorphin; Binding Sites; Cattle; Culture Techniques; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; HEPES; Pineal Gland; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Binding characteristics of delta opioid receptors in different regions of the brain of young and old male rats as studied with the highly selective ligand [D-Pen2-D-Pen5] enkephalin.
Topics: Aging; Animals; Binding, Competitive; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Tissue Distribution | 1992 |
Characterization of opioid receptors mediating stimulation of adenylate cyclase activity in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; Male; Narcotic Antagonists; Olfactory Bulb; Oligopeptides; Opioid Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1992 |
Opioid receptor-mediated inhibition of 3H-dopamine and 14C-acetylcholine release from rat nucleus accumbens slices. A study on the possible involvement of K+ channels and adenylate cyclase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adenylyl Cyclases; Analgesics; Animals; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nucleus Accumbens; Potassium Channels; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1992 |
Modulation of kappa-mediated antitussive activity in rats by a delta-agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Cough; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reflex | 1992 |
Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Topics: Amides; Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glycine; Male; Mice; Molecular Sequence Data; Muscle Contraction; Neuroblastoma; Peptides, Cyclic; Phenylalanine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured; Tyrosine; Vas Deferens | 1992 |
Characterization of opioid receptors in intestinal muscle cells by selective radioligands and receptor protection.
Topics: Animals; Benzeneacetamides; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Intestinal Mucosa; Ligands; Muscle, Smooth; Osmolar Concentration; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Temperature; Time Factors | 1992 |
Central opioid modulation of breathing dynamics in the fetal lamb: effects of [D-Pen2,D-Pen5]-enkephalin and partial antagonism by naltrindole.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetus; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Sheep | 1992 |
Lesioning of the nucleus basalis of Meynert has differential effects on mu, delta and kappa opioid receptor binding in rat brain: a quantitative autoradiographic study.
Topics: Animals; Autoradiography; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Male; Organ Specificity; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Substantia Innominata; Tritium | 1992 |
delta-Opioid receptor binding in mouse brain: evidence for heterogeneous binding sites.
Topics: Animals; Binding, Competitive; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Membranes; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1992 |
Assessment of delta-opioid receptor activation by a series of peptides in cultured cells.
Topics: Amino Acid Sequence; Binding, Competitive; Cell Membrane; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP Phosphohydrolases; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Protein Conformation; Receptors, Opioid, delta; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Bradykinin; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Joints; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
F11 neuroblastoma x DRG neuron hybrid cells express inhibitory mu- and delta-opioid receptors which increase voltage-dependent K+ currents upon activation.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hybrid Cells; Mice; Neuroblastoma; Neurons; Potassium Channels; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1992 |
Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the mu-opioid receptor deficient CXBK mouse.
Topics: Analgesics; Analysis of Variance; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Antinociceptive mechanisms of [D-Arg2]-dermorphin tripeptide analogs.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Mice; Molecular Sequence Data; Naloxone; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu; Synaptosomes | 1992 |
Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nerve Degeneration; Neurons, Afferent; Oligopeptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Spinal Cord | 1992 |
Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Adhesion Molecules; Cell Compartmentation; Cell Membrane; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fluorescent Antibody Technique; GPI-Linked Proteins; In Vitro Techniques; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peptides; Rats; Receptors, Opioid, delta | 1992 |
Interaction between halothane and mu, delta and kappa opioid agonists on the isolated right atria of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Atrial Function; Culture Techniques; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Halothane; Heart Rate; Male; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1992 |
Antinociception produced by receptor selective opioids: modulation of spinal antinociceptive effects by supraspinal opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1992 |
Thermodynamic analysis of the temperature dependence of the dissociation constant of naloxone at opioid delta receptors in the mouse isolated vas deferens.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Receptors, Opioid, delta; Temperature; Thermodynamics; Vas Deferens | 1992 |
Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: dissociation from gastrointestinal effects in mice.
Topics: Adenosine; Analgesia; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Emptying; Gastrointestinal Motility; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Receptors, Opioid; Spinal Cord; Theophylline | 1992 |
Cloning of a delta opioid receptor by functional expression.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Blotting, Southern; Cell Line; Cyclic AMP; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Gene Expression; Humans; Kinetics; Models, Structural; Molecular Sequence Data; Naloxone; Narcotics; Protein Structure, Secondary; Receptors, Opioid, delta; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured | 1992 |
Opioid receptors mediating antinociception from beta-endorphin and morphine in the periaqueductal gray.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid | 1992 |
Monoarthritis induces complex changes in mu-, delta- and kappa-opioid binding sites in the superficial dorsal horn of the rat spinal cord.
Topics: Animals; Arthritis; Arthritis, Experimental; Autoradiography; Benzeneacetamides; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Freund's Adjuvant; Male; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Mu-, delta-, and kappa-opioid receptor agonists selectively modulate sexual behaviors in the female rat: differential dependence on progesterone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Estradiol; Female; Male; Ovariectomy; Posture; Progesterone; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sexual Behavior, Animal | 1992 |
Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Bucladesine; Calcium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Ion Channel Gating; Narcotics; Neuroblastoma; Phorbol 12,13-Dibutyrate; Pyrrolidines; Receptors, Opioid, delta; Tumor Cells, Cultured | 1992 |
Opioid receptors and inhibition of dopamine-sensitive adenylate cyclase in slices of rat brain regions receiving a dense dopaminergic input.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Cyclic AMP; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Frontal Lobe; Hypothalamus; In Vitro Techniques; Male; Nucleus Accumbens; Olfactory Pathways; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Potentiation of opioid analgesia by cocaine: the role of spinal and supraspinal receptors.
Topics: Analgesics, Opioid; Animals; Brain; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Receptors, Opioid; Spinal Cord | 1992 |
Opioids excite dopamine neurons by hyperpolarization of local interneurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Bicuculline; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Mesencephalon; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses | 1992 |
Cyclic AMP accumulation alters calmodulin localization in SK-N-SH human neuroblastoma cells.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Alprostadil; Analgesics; Brimonidine Tartrate; Bucladesine; Calcium; Calmodulin; Carbachol; Cell Line; Colforsin; Cyclic AMP; Cytosol; Edetic Acid; Egtazic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Quinoxalines; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1992 |
Voltage- and time-dependent inhibition of neuronal calcium channels by a GTP-binding protein in a mammalian cell line.
Topics: Acetylcholine; Alprostadil; Animals; Arachidonic Acid; Calcium Channel Blockers; Calcium Channels; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Mollusk Venoms; Neurotransmitter Agents; Norepinephrine; omega-Conotoxin GVIA; Theophylline; Time Factors; Tumor Cells, Cultured | 1992 |
Kappa opioid agonists inhibit transmitter release from guinea pig hippocampal mossy fiber synaptosomes.
Topics: Animals; Azocines; Calcium; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Male; Potassium; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptosomes | 1992 |
Combination of a delta opioid receptor agonist but not a mu opioid receptor agonist with the D1-selective dopamine receptor agonist SKF 38393 markedly potentiates different behaviors in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Grooming; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Motor Activity; Naltrexone; Sulpiride | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
Modulation of peristalsis in the guinea-pig isolated small intestine by exogenous and endogenous opioids.
Topics: Algorithms; Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Narcotics; Peristalsis; Receptors, Opioid | 1992 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Carrageenan; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Inflammation; Injections, Spinal; Ketamine; Kynurenic Acid; Male; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 1992 |
kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures.
Topics: Animals; Benzeneacetamides; Calcium; Cells, Cultured; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Mesencephalon; Narcotics; Potassium; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1992 |
Effects of intracerebroventricularly administered mu-, delta- and kappa-opioid agonists on locomotor activity of the guinea pig and the pharmacology of the locomotor response to U50,488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Hypnotics and Sedatives; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Motor Activity; Narcotics; Peptide Fragments; Piloerection; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Dissociation of mu and delta opioid receptor-mediated reductions in evoked and spontaneous synaptic inhibition in the rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Axons; Baclofen; Bicuculline; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Neurons; Pyramidal Tracts; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Synapses | 1992 |
Inhibition of spinal opioid analgesia by supraspinal administration of selective opioid antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Narcotic Antagonists; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Somatostatin | 1992 |
Effect of mu-, kappa-, and delta-selective opioid agonists on thermoregulation in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Molecular Sequence Data; Morphinans; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Evidence for opiate-dopamine cross-sensitization in nucleus accumbens: studies of conditioned reward.
Topics: Animals; Conditioning, Operant; Dextroamphetamine; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reward | 1992 |
Cholecystokinin octapeptide alters morphine-induced effects on EEG power spectra both quantitatively and qualitatively.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intraventricular; Morphine; Rats; Rats, Sprague-Dawley; Sincalide | 1992 |
Paradoxical analgesia produced by naloxone in diabetic mice is attributable to supersensitivity of delta-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Pain; Pain Measurement; Pyrrolidines; Reaction Time; Time Factors | 1992 |
Whole body and brain distribution of [3H]cyclic [D-Pen2,D-Pen5] enkephalin after intraperitoneal, intravenous, oral and subcutaneous administration.
Topics: Administration, Oral; Animals; Brain; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Tissue Distribution | 1992 |
Amino acid side-chain populations in aqueous and saline solution: bis-penicillamine enkephalin.
Topics: Amino Acid Sequence; Amino Acids; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Molecular Structure; Protein Conformation; Sodium Chloride; Solutions; Thermodynamics; Water | 1992 |
Mobilization of calcium from intracellular store as a possible mechanism underlying the anti-opioid effect of angiotensin II.
Topics: Angiotensin II; Calcium; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Neuroblastoma; Potassium Chloride; Saralasin; Tumor Cells, Cultured | 1992 |
Effects of central administration of opioids on facial scratching in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Face; Injections, Spinal; Macaca fascicularis; Male; Microinjections; Narcotics; Pruritus; Pyrrolidines; Spinal Cord | 1992 |
Opioid peptide interactions with lipid bilayer membranes.
Topics: Amino Acid Sequence; Calorimetry, Differential Scanning; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Lipid Bilayers; Liposomes; Molecular Sequence Data; Permeability; Protein Conformation; Structure-Activity Relationship | 1992 |
Morphine, D-Pen2, D-Pen5 enkephalin and U50,488H differentially affect the locomotor activity and behaviours induced by quinpirole in guinea-pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; Female; Guinea Pigs; Hypnotics and Sedatives; Injections, Intraventricular; Male; Morphine; Motor Activity; Piloerection; Pyrrolidines; Quinpirole | 1992 |
Autoradiographic study of irreversible binding of [3H]beta-funaltrexamine to opioid receptors in the rat forebrain: comparison with mu and delta receptor distribution.
Topics: Animals; Autoradiography; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Telencephalon; Tritium | 1991 |
Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates | 1991 |
Species differences in mu- and delta-opioid receptors.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Kinetics; Male; Mice; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, mu; Receptors, sigma; Species Specificity | 1991 |
Opioid delta receptor subtypes are associated with different potassium channels.
Topics: Analgesics; Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Potassium Channels; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Tetraethylammonium Compounds | 1991 |
The K(+)-evoked release of [3H]acetylcholine from slices of rat globus pallidus: modulation by delta-opioid receptors.
Topics: Acetylcholine; Animals; Choline O-Acetyltransferase; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Globus Pallidus; In Vitro Techniques; Male; Narcotic Antagonists; Physostigmine; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Topographically designed analogues of [D-Pen,D-Pen5]enkephalin.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Mice; Molecular Sequence Data; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Opioid receptor selectivity reversal in deltorphin tetrapeptide analogues.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptosomes | 1991 |
Morphine-6-glucuronide: receptor binding profile in bovine caudate nucleus.
Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Kinetics; Morphine; Morphine Derivatives; Pyrrolidines; Receptors, Opioid | 1991 |
Opioid binding sites in the guinea pig and rat kidney: radioligand homogenate binding and autoradiography.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Cations; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Kidney; Kinetics; Narcotic Antagonists; Nucleotides; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Tritium | 1991 |
Regulation of endogenous calcium and magnesium levels by delta opioid receptors in the rat brain.
Topics: Analgesics; Animals; Brain Chemistry; Calcium; Cations, Divalent; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Magnesium; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spectrophotometry, Atomic | 1991 |
Delta opioid receptor-selective ligands: [D-Pen2,D-Pen5]enkephalin-dermenkephalin chimeric peptides.
Topics: Amino Acid Sequence; Animals; Chimera; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1991 |
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil | 1991 |
Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes.
Topics: Analgesics; Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Opioid receptor subtype involvement in maternal behavior in lactating rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Lactation; Maternal Behavior; Morphine; Phenazocine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Beta-adrenoceptor-sensitive adenylate cyclase is inhibited by activation of mu-opioid receptors in rat striatal neurons.
Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoproterenol; Male; Naloxone; Neuroglia; Neurons; Norepinephrine; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Design and synthesis of opioid receptor selective enkephalin analogues.
Topics: Drug Design; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Receptors, Opioid | 1990 |
Effects of oxymorphindole on morphine induced-antinociception in mice and rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mice; Morphine; Morpholines; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Ventral pallidal microinjections of receptor-selective opioid agonists produce differential effects on circling and locomotor activity in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Functional Laterality; Globus Pallidus; Male; Microinjections; Motor Activity; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior; Time Factors | 1991 |
Biochemical characterization and regional quantification of mu, delta and kappa opioid binding sites in rat spinal cord.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Kinetics; Male; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sufentanil; Tritium | 1991 |
Evidence for two subtypes of delta opioid receptors in rat brain.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein.
Topics: Animals; Calcium Channels; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylmaleimide; GTP-Binding Proteins; In Vitro Techniques; Membrane Potentials; Mollusk Venoms; Neuroblastoma; Neurons; Peptides, Cyclic; Pertussis Toxin; Rats; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Differential effects of mu- and delta-receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices.
Topics: Analysis of Variance; Animals; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feedback; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
An in vitro study on the hippocampal epileptogenic properties of enkephalins and enkephalinase inhibitors in rats.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Epilepsy; Hippocampus; In Vitro Techniques; Male; Morphine; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Rapid agonist-induced loss of 125I-beta-endorphin opioid receptor sites in NG108-15, but not SK-N-SH neuroblastoma cells.
Topics: Analgesics; Animals; beta-Endorphin; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Mice; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1991 |
Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Norepinephrine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Trimebutine | 1991 |
Differences in the binding of [3H][D-Ser2,Thr6]leucine-enkephalin and [3H][D-Pen2,D-Pen5]enkephalin to brain membranes of morphine tolerant-dependent rats.
Topics: Analgesics; Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Ligands; Male; Morphine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Substance-Related Disorders | 1991 |
Effects of local delta and mu opioid receptor activation on basal and stimulated dopamine release in striatum and nucleus accumbens of rat: an in vivo electrochemical study.
Topics: Action Potentials; Animals; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Nucleus Accumbens; Potassium; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy.
Topics: Analgesics; Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Ligands; Male; Nervous System Diseases; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Spinal Cord; Sufentanil | 1991 |
Differential effects of specific opioid receptor agonists on rat pup isolation calls.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Social Isolation; Ultrasonics; Vocalization, Animal | 1991 |
Effects of acute and chronic administration of mu- and delta-opioid agonists on the hypothalamic-pituitary-adrenocortical (HPA) axis in the rat.
Topics: Analgesics; Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypothalamo-Hypophyseal System; Injections, Intraventricular; Male; Pituitary-Adrenal System; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Dissociation of antinociceptive and motor effects of supraspinal opioid agonists in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Pain Measurement; Postural Balance; Psychomotor Performance; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
In vitro evaluation of a casomorphin related pentapeptide, a competitive mu opioid receptor antagonist.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Receptors, Opioid, mu; Vas Deferens | 1991 |
Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro.
Topics: Analgesics; Animals; Animals, Newborn; Astrocytes; Benzeneacetamides; Cells, Cultured; DNA Replication; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Mice, Inbred ICR; Neuroglia; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thymidine | 1991 |
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Binding to opioid receptors of enkephalin derivatives taking alpha-helical conformation and its dimer.
Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Brain Chemistry; Cattle; Cell Membrane; Cells, Cultured; Circular Dichroism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Ligands; Lipid Bilayers; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid | 1991 |
Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Time Factors; Tritium | 1991 |
Desensitization of mu-opioid receptors does not modify the analgesia induced by an enkephalinase inhibitor.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Neprilysin; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan | 1991 |
Effect of opioid agonists selective for three subclasses of opioid receptors and one sigma receptor agonist on dopamine stimulated adenylate cyclase in rat caudate nucleus.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzeneacetamides; Caudate Nucleus; Cyclic AMP; Dopamine; Dopamine Antagonists; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Pertussis toxin abolishes mu- and delta-opioid agonist-induced place preference.
Topics: Animals; Choice Behavior; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Methamphetamine; Mice; Mice, Inbred Strains; Motivation; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride; Virulence Factors, Bordetella | 1991 |
Contribution of supraspinal mu- and delta-opioid receptors to antinociception in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Narcotic Antagonists; Nociceptors; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Identification of opioid receptors on gastric muscle cells by selective receptor protection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Stomach | 1991 |
Characterization of opioid-sensitive neurons in the anteroventral third ventricle region of polydipsic inbred mice in vitro.
Topics: Angiotensin II; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Drinking Behavior; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypothalamus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Neurons; Peptide Fragments; Species Specificity | 1991 |
Effects of receptor-selective opioids on operant behavior in morphine-treated and untreated rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Food; Infusions, Intravenous; Injections, Intraventricular; Male; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Effect of opioid peptides on circular muscle of canine duodenum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Muscles; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid | 1991 |
Naltrexone-sensitizing effects of centrally administered morphine and opioid peptides.
Topics: Animals; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Opioids can produce a concentration-dependent naloxone-reversible enhancement of inhibition of evoked enkephalin release.
Topics: Analgesics; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Naloxone; Narcotics; Parasympatholytics; Sufentanil; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes.
Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Molecular Sequence Data; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Somatostatin | 1991 |
Activation of mu opioid receptors in the pre-optic-anterior hypothalamus releases prolactin in the conscious male rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anterior Hypothalamic Nucleus; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Preoptic Area; Prolactin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Opioids at low concentration decrease openings of K+ channels in sensory ganglion neurons.
Topics: Action Potentials; Animals; Dynorphins; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Narcotic Antagonists; Narcotics; Neurons, Afferent; Osmolar Concentration; Potassium Channels | 1991 |
Dopaminergic system mediates only delta-opiate inhibition of endogenous acetylcholine release evoked by glutamate from rat striatal slices.
Topics: Acetylcholine; Animals; Benzazepines; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Male; Morphine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Secretory Rate | 1991 |
[D-Ala2,NMePhe4,Gly-ol5]enkephalin, but not [D-Pen2,L-Pen5]enkephalin, specifically inhibits behaviors induced by the dopamine D2 agonist RU 24213.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Motor Activity; Naltrexone; Phenethylamines | 1991 |
Modulation of cholinergic neurotransmission in guinea-pig airways by opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Bronchi; Capsaicin; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Narcotics; Parasympathetic Nervous System; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance P; Synaptic Transmission; Trachea | 1990 |
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Morphine; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Theophylline; Vasoactive Intestinal Peptide | 1990 |
Neurohormonal regulation of ion transport in the porcine distal jejunum. Enhancement of sodium and chloride absorption by submucosal opiate receptors.
Topics: Analgesics; Animals; Chlorides; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ion Channels; Jejunum; Narcotics; Receptors, Opioid; Sodium Channels; Swine | 1991 |
Morphine, but not sodium cromoglycate, modulates the release of substance P from capsaicin-sensitive neurones in the rat trachea in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Bradykinin; Capsaicin; Cromolyn Sodium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Neurons; Potassium Chloride; Pyrrolidines; Rats; Rats, Inbred Strains; Substance P; Trachea | 1991 |
Mu and kappa opioid receptor modulation of 5-HT3 and NK-3 receptor-evoked release of acetylcholine from the guinea-pig ileum myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Choline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptide Fragments; Pyrrolidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Serotonin; Receptors, Tachykinin; Serotonin; Substance P; Tritium | 1991 |
Differential effect of intrastriatal kainic acid on the modulation of dopamine release by mu- and delta-opioid peptides: a microdialysis study.
Topics: Animals; Corpus Striatum; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Extracellular Space; Injections; Kainic Acid; Male; Rats; Rats, Inbred Strains | 1992 |
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
Topics: Analgesics; Animals; Binding, Competitive; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Neprilysin; Tissue Distribution; Tritium | 1991 |
Dynamical search for bis-penicillamine enkephalin conformations.
Topics: Calorimetry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation; Thermodynamics | 1991 |
Topographical requirements for delta-selective opioid peptides.
Topics: Amino Acid Sequence; Computer Simulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Models, Molecular; Molecular Sequence Data; Oligopeptides; Protein Conformation | 1991 |
Comparative conformational analysis of [D-Pen2,D-Pen5]enkephalin (DPDPE): a molecular mechanics study.
Topics: Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Molecular Structure; Protein Conformation; Software; Thermodynamics | 1991 |
Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle, Smooth; Myenteric Plexus; Narcotics; Pertussis Toxin; Pyrrolidines; Sufentanil; Virulence Factors, Bordetella | 1991 |
Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Mollusk Venoms; Naltrexone; Narcotic Antagonists; omega-Conotoxin GVIA; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Heroin acts on different opioid receptors than morphine in Swiss Webster and ICR mice to produce antinociception.
Topics: Analgesia; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Methysergide; Mice; Mice, Inbred ICR; Morphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Species Specificity; Spinal Cord; Yohimbine | 1991 |
Influence of peptidase inhibitors on the apparent agonist potency of delta selective opioid peptides in vitro.
Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1991 |
Partial depletion of endogenous zinc level by (D-Pen2, D-Pen5)enkephalin in the rat brain.
Topics: Analgesics; Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hippocampus; Injections, Intraventricular; Olfactory Bulb; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Time Factors; Zinc | 1991 |
Effects of selective opioid agonists on feline colonic transit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cattle; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Loperamide; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil | 1991 |
Differential effects of neuropeptide Y and opioids on neurogenic responses of the perfused rat mesentery.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Guanethidine; In Vitro Techniques; Male; Methoxamine; Muscle, Smooth, Vascular; Narcotics; Neuropeptide Y; Rats; Rats, Inbred Strains; Splanchnic Circulation; Vasoconstriction; Vasodilation | 1991 |
Comparison of the antinociceptive and motor effects of intrathecal opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Narcotic Antagonists; Pain; Postural Balance; Psychomotor Performance; Pyrrolidines; Rats; Rats, Inbred Strains; Sensory Thresholds | 1991 |
Neostriatal dopaminergic terminals prevent the GABAergic involvement in the mu- and delta-opioid inhibition of KCl-evoked endogenous acetylcholine release.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; gamma-Aminobutyric Acid; Male; Nerve Endings; Oxidopamine; Potassium Chloride; Rats; Rats, Inbred Strains | 1991 |
Opiate receptors in neuronal primary cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fetus; Morphine; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Evidence for phosphatidylinositol anchorage of opioid binding proteins in rat brain.
Topics: Animals; Autoradiography; beta-Endorphin; Brain Chemistry; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Iodine Radioisotopes; Membranes; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Protein Binding; Rats; Receptors, Opioid; Thalamus | 1990 |
Effects of drugs interacting with opioid receptors during normal perfusion or ischemia and reperfusion in the isolated rat heart--an attempt to identify cardiac opioid receptor subtype(s) involved in arrhythmogenesis.
Topics: Animals; Arrhythmias, Cardiac; Benzomorphans; Coronary Disease; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Receptors, Opioid | 1990 |
Characterisation of opioid binding sites using selective antagonists.
Topics: Animals; Binding, Competitive; Brain; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Morphinans; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
Involvement of central mu and delta opioid receptors in mediating the reinforcing effects of beta-endorphin in the rat.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Somatostatin | 1990 |
Effects of preferential delta and kappa opioid receptor agonists on the intake of hypotonic saline.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drinking; Dynorphins; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Food Preferences; Hypotonic Solutions; Injections, Intraventricular; Male; Oligopeptides; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Taste | 1990 |
The antinociceptive role of mu- and delta-opiate receptors and their interactions in the spinal dorsal horn of cats.
Topics: Analgesics, Opioid; Animals; Cats; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ganglia, Spinal; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Characterization of opioid receptors modulating the function of capsaicin-sensitive neurons in guinea-pig atria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Benzomorphans; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Male; Morphine; Neurons; Pyrrolidines; Receptors, Opioid; Reserpine | 1990 |
Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Neurons, Afferent; Oligopeptides; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Reserpine | 1990 |
Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice.
Topics: Analgesia; Animals; beta-Endorphin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Somatostatin | 1990 |
Cholecystokinin octapeptide antagonized opioid analgesia mediated by mu- and kappa- but not delta-receptors in the spinal cord of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Proglumide; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Spinal Cord | 1990 |
Effect of opioids on acetylcholine release evoked by K+ or glutamic acid from rat neostriatal slices.
Topics: Acetylcholine; Animals; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamates; Glutamic Acid; In Vitro Techniques; Luminescent Measurements; Male; Morphine; Naloxone; Narcotics; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1990 |
The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study.
Topics: Analgesics; Animals; Dialysis; Dopamine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Magnesium; Male; Nucleus Accumbens; Peptide Fragments; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin | 1990 |
The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors.
Topics: Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium; Vas Deferens | 1990 |
Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Medulla Oblongata; Morphine; Neurons; Quinoxalines; Rats | 1990 |
Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Autoradiography; Cerebral Cortex; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Humans; Iodocyanopindolol; Ketanserin; Male; Middle Aged; Oxotremorine; Paroxetine; Pindolol; Piperidines; Pirenzepine; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Opioid; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1990 |
Autoradiographic localization of delta opioid receptors within the mesocorticolimbic dopamine system using radioiodinated [2-D-penicillamine, 5-D-penicillamine]enkephalin (125I-DPDPE).
Topics: Animals; Autoradiography; Binding, Competitive; Cerebral Cortex; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydroxydopamines; Immunochemistry; In Vitro Techniques; Iodine Radioisotopes; Limbic System; Male; Oxidopamine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Sympathectomy, Chemical; Tyrosine 3-Monooxygenase | 1990 |
Phorbol ester suppression of opioid analgesia in rats.
Topics: Analgesia; Animals; Calcium; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Peptide Fragments; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Spinal Cord; Tetradecanoylphorbol Acetate | 1990 |
Analgesic synergy and improved motor function produced by combinations of mu-delta- and mu-kappa-opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Narcotics; Psychomotor Performance; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
GABAA and GABAB antagonists prevent the opioid inhibition of endogenous acetylcholine release evoked by glutamate from rat neostriatal slices.
Topics: Acetylcholine; Animals; Baclofen; Bicuculline; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Activation of mu- and delta-opioid receptors present on the same nerve terminals depresses transmitter release in the mouse hypogastric ganglion.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Ganglia; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Nerve Endings; Neurotransmitter Agents; Oligopeptides; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Identification of the opioid receptor types mediating beta-endorphin-induced alterations in dopamine release in the nucleus accumbens.
Topics: Analgesics; Animals; beta-Endorphin; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Somatostatin | 1990 |
Theoretical study of the flexibility and solution conformation of the cyclic opioid peptides [D-Pen2,D-Pen5]enkephalin and [D-Pen2,L-Pen5]enkephalin.
Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Protein Conformation; Solutions; Stereoisomerism; Structure-Activity Relationship; Temperature; Thermodynamics | 1991 |
Delta opioid antagonist, naltrindole, selectively blocks analgesia induced by DPDPE but not DAGO or morphine.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Restraint, Physical; Stress, Psychological | 1991 |
Spinally mediated opioid antidiarrheal effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidiarrheals; Body Weight; Diarrhea; Dinoprostone; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Pyrrolidines; Spinal Cord | 1991 |
Conformational search in enkephalin analogues containing a disulfide bond.
Topics: Amino Acid Sequence; Disulfides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Models, Molecular; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Thermodynamics | 1990 |
[D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors.
Topics: Amino Acid Sequence; Animals; Brain; Chemical Phenomena; Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Molecular Sequence Data; Muscle Contraction; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1990 |
Developmental pattern of opioid receptors in the striatum and hippocampus: evidence for a non-mature type of receptor in embryonic tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hippocampus; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Regional differences in opioid receptor-mediated inhibition of dopamine and acetylcholine release in the rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Brain; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Pyrrolidines; Rats; Receptors, Opioid; Tissue Distribution | 1990 |
The novel antagonist profile of (-)metazocine.
Topics: Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphinans; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1990 |
Modulation of the analgesic efficacy and potency of morphine by [D-Pen2, D-Pen5]enkephalin in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Antinociceptive actions of novel delta opioid receptor agonists in the mouse.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
[3H] beta-funaltrexamine ([3H] beta-FNA) binds irreversibly to mu opioid receptors in the rat brain: autoradiographic study.
Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Kappa- and delta-opioid agonists synergize to produce potent analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1990 |
Evidence for delta-opioid binding and GTP-regulatory proteins in 5-day-old rat brain membranes.
Topics: Animals; Animals, Newborn; Binding, Competitive; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanine Nucleotides; Guanylyl Imidodiphosphate; Membranes; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Software | 1990 |
Lack of antinociceptive cross-tolerance between intracerebroventricularly administered beta-endorphin and morphine or DPDPE in mice.
Topics: Analgesics; Animals; beta-Endorphin; Brain; Cross Reactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Receptors, Opioid | 1990 |
Stress-induced tolerance to delta receptor agonist DPDPE and selectivity of the irreversible delta-ligand, DALCE.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Restraint, Physical; Stress, Psychological | 1990 |
Dog cerebral cortex contains mu-, delta- and kappa-opioid receptors at different densities: apparent lack of evidence for subtypes of the kappa-receptor using selective radioligands.
Topics: Animals; Cerebral Cortex; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1990 |
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses.
Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1990 |
Modulation by muscarine and opioid receptors of acetylcholine release in slices from striato-striatal grafts in the rat.
Topics: Acetylcholine; Animals; Cholinergic Fibers; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Rats; Receptors, Muscarinic; Receptors, Opioid | 1990 |
Opioid modulation of basal intestinal fluid transport in the mouse: actions at central, but not intestinal, sites.
Topics: Analgesics; Animals; Body Fluids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraperitoneal; Intestinal Mucosa; Intestines; Levallorphan; Male; Mice; Mice, Inbred ICR; Receptors, Opioid | 1990 |
[3H][D-Pen2, D-Pen5]enkephalin binding to delta opioid receptors on intact neuroblastoma-glioma (NG 108-15) hybrid cells.
Topics: Animals; Binding, Competitive; Cell Survival; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hybrid Cells; Kinetics; Mice; Models, Biological; Morphine; Morphine Derivatives; Receptors, Opioid | 1990 |
Tolerance to delta- but not mu-opioid receptors in the spinal cord attenuates inhibition of the tail-flick response induced by beta-endorphin administered intracerebroventricularly in mice.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Intrathecal administration of delta receptor agonists in the urethane anesthetized rat provokes an increase in arterial pressure via a non-opioid mechanism.
Topics: Anesthesia; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Injections, Spinal; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord; Urethane | 1990 |
Proglumide selectively potentiates supraspinal mu 1 opioid analgesia in mice.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamine; Male; Mice; Morphine; Morphine Dependence; Narcotics; Proglumide; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Central opioid modulation of fetal cardiovascular function: role of mu- and delta-receptors.
Topics: Analysis of Variance; Animals; Brain; Cardiovascular System; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fetal Heart; Fetus; Heart Rate; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sheep | 1990 |
Brain mu and delta opioid receptors mediate different locomotor hyperactivity responses of the C57BL/6J mouse.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1990 |
Characterization of opioid receptors in cultured neurons.
Topics: Animals; Benzomorphans; Brain; Cell Membrane; Cells, Cultured; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Fluorescent Antibody Technique; Hippocampus; Hypothalamus; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
An attempt to structurally convert mu-selective morphine toward delta-receptor binding: dimerization based on enkephalin conformation.
Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1990 |
Demonstration of the heterogeneity of the kappa-opioid receptors in guinea-pig cerebellum using selective and nonselective drugs.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cerebellum; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Delta-opioid receptor binding sites in rodent spinal cord.
Topics: Analgesics; Animals; Autoradiography; Binding, Competitive; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Injections, Spinal; Male; Mesocricetus; Mice; Mice, Inbred Strains; Naloxone; Psychomotor Performance; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.
Topics: Analgesics; Animals; Codeine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Modification by cholecystokinin octapeptide of the binding of mu-, delta-, and kappa-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Kinetics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective delta agonist in vivo.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Medial preoptic-anterior hypothalamic area involvement in the suppression of pulsatile LH release by a mu-opioid agonist in the ovariectomized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anterior Hypothalamic Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Kinetics; Luteinizing Hormone; Ovariectomy; Preoptic Area; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors | 1990 |
Modulation of opioid receptor binding by cis and trans fatty acids.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fatty Acids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism | 1990 |
Opioid agonist and antagonist antinociceptive properties of [D-Ala2,Leu5,Cys6]enkephalin: selective actions at the deltanoncomplexed site.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Naloxone benzoylhydrazone (NalBzoH) analgesia.
Topics: Analgesia; Analgesics; Animals; Azocines; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Female; Injections, Intraventricular; Morphine; Pituitary Gland, Posterior; Plasma; Preoptic Area; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1990 |
Cyclic dermorphin-like tetrapeptides with delta-opioid receptor selectivity. 3. Effect of residue 3 modification on in vitro opioid activity.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Oligopeptides; Opioid Peptides; Protein Conformation; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1990 |
Differential effect of mu, delta, and kappa ligands on G protein alpha subunits in cultured brain cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cells, Cultured; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rhombencephalon; Signal Transduction; Telencephalon; Up-Regulation | 1990 |
Distinct antinociceptive actions mediated by different opioid receptors in the region of lamina I and laminae III-V of the dorsal horn of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Neurons; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1990 |
Distribution of mu, delta, and kappa opioid receptor binding sites in the brain of the one-day-old domestic chick (Gallus domesticus): an in vitro quantitative autoradiographic study.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Brain; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Organ Specificity; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1990 |
Differential effects of cyanogen bromide on ligand binding by mu, delta and kappa opioid receptors.
Topics: Animals; Brain; Cell Membrane; Cyanogen Bromide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ligands; Male; Methionine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Hyperpolarizing action of enkephalin on neurons in the dorsal motor nucleus of the vagus, in vitro.
Topics: Action Potentials; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Medulla Oblongata; Membrane Potentials; Naloxone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vagus Nerve | 1990 |
Single residue modifications of the delta opioid receptor selective peptide, [D-Pen2,D-Pen5]-enkephalin (DPDPE). Correlation of pharmacological effects with structural and conformational features.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1990 |
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1990 |
Selective modulation of morphine antinociception, but not development of tolerance, by delta receptor agonists.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Inhibition of neuronally induced relaxation of canine lower esophageal sphincter by opioid peptides.
Topics: Animals; Autonomic Nervous System; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dogs; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Esophagogastric Junction; Ethylketocyclazocine; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Neurons; Phenazocine | 1990 |
Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis.
Topics: Analgesics; Animals; Benzeneacetamides; Clonidine; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Regression Analysis; Spinal Cord | 1990 |
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior | 1990 |
Alteration of thermoregulatory set point with opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature Regulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains | 1990 |
Opioid regulation of mucosal ion transport in the mouse isolated jejunum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Biological Transport; Chlorides; Electrolytes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Intestinal Mucosa; Jejunum; Mice; Morphine; Pyrrolidines; Sodium | 1990 |
Attenuation of reflex pressor and ventilatory responses to static muscular contraction by intrathecal opioids.
Topics: Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Heart Rate; Injections, Spinal; Muscle Contraction; Respiration; Sciatic Nerve | 1990 |
Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Diltiazem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immobilization; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Nifedipine; Pain; Reaction Time; Stress, Physiological; Verapamil | 1987 |
Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.
Topics: Animals; beta-Endorphin; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Ion Channels; Locus Coeruleus; Membrane Potentials; Narcotics; Neurons; Potassium; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Inhibition of exocrine pancreatic secretion by opiates is mediated by suppression of cholinergic transmission: characterization of receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Amylases; Animals; Cholinergic Fibers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Narcotics; Pancreas; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptic Transmission | 1988 |
Substance P release from knee joint afferent terminals: modulation by opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Afferent Pathways; Animals; Capsaicin; Cats; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Hindlimb; Joints; Narcotics; Pyrrolidines; Reference Values; Sciatic Nerve; Substance P; Sufentanil | 1988 |
Opioid modulation of non-cholinergic neural bronchoconstriction in guinea-pig in vivo.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Bronchi; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Morphine; Receptors, Opioid; Substance P; Sympathetic Nervous System; Vagus Nerve | 1988 |
Mu and delta opioid receptors inhibit serotonin release in rat hippocampus.
Topics: Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Hippocampus; In Vitro Techniques; Male; Pertussis Toxin; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin; Virulence Factors, Bordetella | 1989 |
Relationship between opioid-receptor occupancy and stimulation of low-Km GTPase in brain membranes.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; Guanosine Triphosphate; Magnesium; Membranes; Naltrexone; Oligopeptides; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1989 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds | 1989 |
Influence of opioid peptides on learning and memory processes in the chick.
Topics: Animals; Attention; beta-Endorphin; Brain Mapping; Chickens; Discrimination Learning; Dominance, Cerebral; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Memory; Mental Recall; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Visual Cortex | 1989 |
Characterization of high affinity opioid binding sites in rat periaqueductal gray P2 membrane.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Membranes; Periaqueductal Gray; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antidiarrheals; Constipation; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Evidence for the presence of mu- and kappa- but not of delta-opioid sites in the human fetal brain.
Topics: Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Male; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1989 |
Behavioural effects of selective mu-, kappa-, and delta-opioid agonists in neonatal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesics; Animals; Animals, Newborn; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Morphine; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Delta opioid antagonist, 16-Me cyprenorphine, selectively attenuates conditional fear- and DPDPE-induced analgesia on the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fear; Female; Formaldehyde; Injections, Intraventricular; Morphinans; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Dermenkephalin (Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2): a potent and fully specific agonist for the delta opioid receptor.
Topics: Amino Acid Sequence; Analgesia; Animals; Binding, Competitive; Brain; Cell Membrane; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Kinetics; Male; Mice; Oligopeptides; Opioid Peptides; Pain; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Substantia nigra as a site of origin of dopamine-dependent motor syndromes induced by stimulation of mu and delta opioid receptors.
Topics: Animals; Dopamine; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Substantia Nigra | 1989 |
Mu type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to G-protein-mediated inhibition of adenylyl cyclase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; In Vitro Techniques; Periaqueductal Gray; Pertussis Toxin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1989 |
Modulation of mu-mediated antinociception by delta agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2,D-Pen5]enkephalin.
Topics: Animals; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Effects of pertussis toxin on opioid regulation of catecholamine release from rat and guinea pig brain slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Catecholamines; Corpus Striatum; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Male; Narcotics; Pertussis Toxin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1989 |
Guanine nucleotide regulation of [125I]beta-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements.
Topics: beta-Endorphin; Cations; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Hybrid Cells; Neuroblastoma; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride; Tumor Cells, Cultured | 1989 |
Central and peripheral opioid modulation of gastric relaxation induced by feeding in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Dogs; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Morphine; Muscle Relaxation; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagotomy; Vagus Nerve | 1989 |
Jejunal proabsorptive actions of selective opiate agonists administered via the cerebral ventricles.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Animals; Body Water; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Intestinal Absorption; Jejunum; Kinetics; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
A comparison among antinociceptive bioassays for mu and delta agonists.
Topics: Analgesics; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
RX809055AX in vivo: a long lasting opioid antagonist at mu and delta receptors.
Topics: Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Opioid receptor selectivity of peptide models of beta-endorphin.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
The antinociception produced by intrathecal morphine, calcium, A23187, U50,488H, [D-Ala2, N-Me-Phe4, Gly-ol]enkephalin and [D-Pen2, D-Pen5]enkephalin after intrathecal administration of calcitonin gene-related peptide in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Calcimycin; Calcitonin Gene-Related Peptide; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Morphine; Pyrrolidines; Receptors, Opioid; Spinal Cord | 1989 |
A high affinity, highly selective ligand for the delta opioid receptor: [3H]-[D-Pen2, pCl-Phe4, d-Pen5]enkephalin.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
mu-Opioid peptide modulation of cardiovascular and sympathoadrenal responses to stress.
Topics: Animals; Blood Pressure; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Restraint, Physical; Stress, Psychological; Time Factors | 1989 |
Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus.
Topics: Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphine; Naltrexone; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Indirect involvement of delta opioid receptors in cholecystokinin octapeptide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Sincalide | 1989 |
Multi-dimensional analysis of behavior in mice treated with the delta opioid agonists DADL (D-Ala2-D-Leu5-enkephalin) and DPLPE (D-Pen2-L-Pen5-enkephalin).
Topics: Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Different mu receptor subtypes mediate spinal and supraspinal analgesia in mice.
Topics: Analgesia; Anesthesia, Spinal; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution.
Topics: Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Blood Glucose; Brain Chemistry; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Injections, Intraventricular; Medulla Oblongata; Naloxone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Respiration | 1989 |
Opioid receptors in rat cardiac sarcolemma: effect of phenylephrine and isoproterenol.
Topics: Analgesics; Animals; Benzeneacetamides; Bromides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypotonic Solutions; Isoproterenol; Lithium; Lithium Compounds; Myocardium; Phenylephrine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sarcolemma | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Sympathoadrenal, cardiovascular and blood gas responses to highly selective mu and delta opioid peptides.
Topics: Animals; Blood Pressure; Carbon Dioxide; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Heart Rate; Male; Naloxone; Oxygen; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Characterization of opioid receptors in rat nucleus accumbens following mesolimbic dopaminergic lesions.
Topics: Animals; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydroxydopamines; Ibotenic Acid; Limbic System; Male; Nucleus Accumbens; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1989 |
A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.
Topics: Anesthetics; Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
[3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain.
Topics: Animals; Brain; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Kinetics; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sodium; Somatostatin; Temperature; Tritium | 1989 |
Dermorphin gene sequence peptide with high affinity and selectivity for delta-opioid receptors.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Oligopeptides; Opioid Peptides; Protein Conformation; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes | 1989 |
Differential modulation by [D-Pen2, D-Pen5]enkephalin and dynorphin A-(1-17) of the inhibitory bladder motility effects of selected mu agonists in vivo.
Topics: Analgesics; Animals; Drug Synergism; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Morphine; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Urinary Bladder | 1989 |
Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Oligopeptides; Rabbits; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1989 |
Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid | 1989 |
Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.
Topics: Action Potentials; Animals; Colforsin; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; Guinea Pigs; Myenteric Plexus; Naloxone; Sufentanil | 1989 |
[High and low frequency electroacupuncture analgesia are mediated by different types of opioid receptors at spinal level: a cross tolerance study].
Topics: Acupuncture Analgesia; Analgesics; Animals; Dynorphins; Electroacupuncture; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Peptide Fragments; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1989 |
Novel [D-Pen2, D-Pen5]enkephalin derivatives with increased sigma receptor potency and selectivity: potential tools for opioid pharmacology.
Topics: Analgesics, Opioid; Animals; Chemical Phenomena; Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Mice; Nociceptors; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, sigma; Structure-Activity Relationship | 1989 |
DPen2-[DPen5]enkephalin, a delta opioid receptor-selective analog of [Leu]enkephalin, impairs avoidance learning in an automated shelf-jump task in rats.
Topics: Animals; Avoidance Learning; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Inbred Strains; Task Performance and Analysis | 1989 |
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Sulfhydryl Reagents | 1989 |
Effect of calcium ion on analgesia of opioid peptides.
Topics: Analgesia; Animals; Calcium Chloride; Central Nervous System; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intraventricular; Injections, Spinal; Morphine; Rats; Rats, Inbred Strains | 1989 |
Opioid receptor regulation of the release of norepinephrine in brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Models, Neurological; Naloxone; Norepinephrine; Potassium; Pyrrolidines; Receptors, Opioid | 1987 |
Colonic bead expulsion time in normal and mu-opioid receptor deficient (CXBK) mice following central (ICV) administration of mu- and delta-opioid agonists.
Topics: Animals; Colon; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Morphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1987 |
Opioid receptor subtypes associated with ventral tegmental facilitation of lateral hypothalamic brain stimulation reward.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypothalamic Area, Lateral; Male; Morphine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward | 1987 |
Opioid receptor subtypes associated with ventral tegmental facilitation and periaqueductal gray inhibition of feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Hypothalamic Area, Lateral; Male; Morphine; Periaqueductal Gray; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tegmentum Mesencephali | 1987 |
Peptide opioid antagonist separates peripheral and central opioid antitransit effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Comparison of [125I]beta-endorphin binding to rat brain and NG108-15 cells using a monoclonal antibody directed against the opioid receptor.
Topics: Animals; Antibodies, Monoclonal; beta-Endorphin; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Immunoglobulin M; In Vitro Techniques; Iodine Radioisotopes; Male; Molecular Weight; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1988 |
Characterization of D-Ala2,Leu5,Cys6-enkephalin: a novel synthetic opioid peptide with slowed dissociation from delta receptors.
Topics: Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
[3H]DSTBULET, a new linear hexapeptide with both an improved selectivity and a high affinity for delta-opioid receptors.
Topics: Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1986 |
Anomalous binding of DPDPE as a result of batch variability.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Quality Control; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Binding to mu and delta opioid sites but not kappa sites is inhibited by Fab fragments from a monoclonal antibody directed against the opioid receptor.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; beta-Endorphin; Cell Membrane; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Immunoglobulin Fab Fragments; Kinetics; Male; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Autoradiographic localization of opioid receptor types in the rat small intestine.
Topics: Animals; Autoradiography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Intestine, Small; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1986 |
Mu/delta opioid site selectivity of some antidepressants.
Topics: Animals; Antidepressive Agents; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Evidence for delta receptor mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) analgesia in mice.
Topics: Analgesia; Animals; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
In vivo studies on delta opioid receptors.
Topics: Animals; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
The role of mu- and delta- opioid receptors on the intestinal propulsion in rats.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Gastrointestinal Transit; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Binding characteristics of [D-Ala2-MePhe4-Glyol5] enkephalin and [D-Pen2,D-Pen5] enkephalin in rat brain: inhibition studies with fentanyl-like drugs.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Kinetics; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Development of delta-opioid receptors in rat brain characterised by [3H]-[D-Pen2,D-Pen5] enkephalin binding.
Topics: Aging; Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Interaction between highly selective mu and delta opioids in vivo at the rat spinal cord.
Topics: Analgesics; Animals; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1986 |
Motivational properties of opioids: evidence that an activation of delta-receptors mediates reinforcement processes.
Topics: Animals; Appetitive Behavior; Avoidance Learning; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Morphine; Motivation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Reinforcement, Psychology | 1987 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
[3H][D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6(O-tert-butyl). Two new enkephalin analogs with both a good selectivity and a high affinity toward delta-opioid binding sites.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Kinetics; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Affinity crosslinking of 125I-labeled human beta-endorphin to cell lines possessing either mu- or delta-type opioid binding sites.
Topics: beta-Endorphin; Binding Sites; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse.
Topics: Analgesia; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Species Specificity | 1988 |
Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: studies with naloxonazine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
LY164929: a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Membranes; Models, Biological; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
U50,488H differentially antagonizes the bladder effects of mu agonists at spinal sites.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Morphine Derivatives; Muscle Contraction; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1988 |
Role of mu 1-opiate receptors in supraspinal opiate analgesia: a microinjection study.
Topics: Analgesia; Animals; Brain; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Male; Microinjections; Morphine; Oligopeptides; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord | 1988 |
Mu-, but not delta-, opioid receptor-mediated antinociception in mice is attenuated by gamma-irradiation.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gamma Rays; Injections, Intraventricular; Male; Mice; Morphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Rotational behavior mediated by dopaminergic and nondopaminergic mechanisms after intranigral microinjection of specific mu, delta and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydroxydopamines; Male; Microinjections; Motor Activity; Naloxone; Narcotics; Oxidopamine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rotation | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Body temperature response profiles for selective mu, delta and kappa opioid agonists in restrained and unrestrained rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical | 1988 |
Fentanyl isothiocyanate reveals the existence of physically associated mu- and delta-opioid receptors mediating inhibition of adenylate cyclase in rat neostriatum.
Topics: Adenylyl Cyclase Inhibitors; Animals; Caudate Nucleus; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; In Vitro Techniques; Isothiocyanates; Male; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Analgesic and tolerance-inducing effects of the highly selective delta opioid agonist [D-Pen2,D-Pen5]enkephalin in mice.
Topics: Analgesics; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Pain; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Sensory Thresholds; Substance-Related Disorders | 1988 |
Opioid receptor selectivity of beta-endorphin in vitro and in vivo: mu, delta and epsilon receptors.
Topics: Analgesia; Animals; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Gastric Emptying; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1988 |
Comparative binding of mu and delta selective ligands in whole brain and pons/medulla homogenates from rat: affinity profiles of fentanyl derivatives.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Male; Medulla Oblongata; Narcotic Antagonists; Pons; Rats; Rats, Inbred Strains | 1988 |
Stimulation and antagonism of opioid delta-receptors produce opposite effects on active avoidance conditioning in mice.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Mice; Motor Activity; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Evidence for opioid receptor interactions in vivo.
Topics: Animals; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Narcotics; Pain; Receptors, Opioid | 1988 |
Autoradiographic localization of delta opiate receptors in rat and human brain.
Topics: Animals; Autoradiography; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Role of steric interactions in the delta opioid receptor selectivity of [D-Pen2, D-Pen5]enkephalin.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Pertussis toxin pretreatment antagonizes the actions of mu- and delta-opiate agonists in hippocampal slices.
Topics: Action Potentials; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1988 |
Depression of potassium-evoked striatal acetylcholine release by delta-receptor activation: inhibition by cholinoactive agents.
Topics: Acetylcholine; Analgesics; Animals; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Neostigmine; Oxotremorine; Physostigmine; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Opiate receptor subtypes in the nucleus tractus solitarii of the cat: the effect of vagal section.
Topics: Animals; Autoradiography; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Female; Male; Medulla Oblongata; Naloxone; Receptors, Opioid; Vagotomy | 1988 |
Cyclic somatostatin octapeptide analogues with high affinity and selectivity toward mu opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, Somatostatin; Somatostatin; Structure-Activity Relationship | 1986 |
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hypercapnia; Hypoxia; Peptide Fragments; Receptors, Opioid | 1986 |
Centrally-administered opioid selective agonists inhibit drinking in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Drinking Behavior; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid | 1986 |
Interactions of Tyr-MIF-1 at opiate receptor sites.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Purified opioid mu-receptor is of a different molecular size than delta- and kappa-receptors.
Topics: Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Mu opioid antagonist properties of a cyclic somatostatin octapeptide in vivo: identification of mu receptor-related functions.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred ICR; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1987 |
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2: a potent and selective antagonist opioid receptors.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1986 |
Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydrazines; Morphine; Peptide Fragments; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin | 1987 |
Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GABA Antagonists; Hippocampus; Interneurons; Naloxone; Oligopeptides; Rats; Receptors, Opioid | 1988 |
Selectivity of ligand binding to opioid receptors in brain membranes from the rat, monkey and guinea pig.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain Chemistry; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Haplorhini; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Sufentanil; Tritium | 1988 |
Direct dependence studies in rats with agents selective for different types of opioid receptor.
Topics: Analgesics; Animals; Behavior, Animal; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders | 1988 |
Opiate binding in calf thalamic membranes: a selective mu 1 binding assay.
Topics: Animals; Cattle; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus | 1988 |
Effects of intrahypothalamic administration of opioid peptides selective for mu-, kappa, and delta-receptors on different schedules of water intake in the rat.
Topics: Animals; Drinking Behavior; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Saline Solution, Hypertonic; Time Factors | 1988 |
Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in cats.
Topics: Animals; Cats; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Naloxone; Narcotic Antagonists; Narcotics; Peptide Fragments; Stomach; Vagus Nerve | 1988 |
Differences in the characteristics of opioid receptor binding in the rat and marmoset.
Topics: Animals; Callitrichinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Male; Rats; Receptors, Opioid; Species Specificity | 1988 |
Characterization of the receptor binding profile of (3H)-dermorphin in the rat brain.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Oligopeptides; Opioid Peptides; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tritium | 1988 |
Guanine nucleotide regulation of [125I]beta-endorphin binding to rat brain membranes: monovalent cation requirement.
Topics: Animals; beta-Endorphin; Brain; Cations, Monovalent; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Lithium; Male; Phenazocine; Potassium; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride | 1988 |
Beta-endorphin-(1-27) antagonizes beta-endorphin- but not morphine-, D-Pen2-D-Pen5-enkephalin- and U50, 488H-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Peptide Fragments; Pyrrolidines; Reaction Time | 1988 |
Comparative binding properties of linear and cyclic delta-selective enkephalin analogues: [3H]-[D-Thr2, Leu5] enkephalyl-Thr6 and [3H]-[D-Pen2, D-Pen5] enkephalin.
Topics: Animals; Brain; Cell Line; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guinea Pigs; Isomerism; Kinetics; Neuroblastoma; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15).
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Kinetics; Membranes; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Studies in vivo with ICI 174864 and [D-Pen2, D-Pen5]enkephalin.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Gastrointestinal Motility; Male; Mice; Motor Activity; Posture; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Studies in vitro with ICI 174,864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO).
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
The use of [3H]-[D-Pen2,D-Pen5]enkephalin as a highly selective ligand for the delta-binding site.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Ligands; Male; Morphine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Tritium | 1985 |
Autoradiographic localization of delta opioid receptors in the rat brain using a highly selective bis-penicillamine cyclic enkephalin analog.
Topics: Animals; Autoradiography; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Tritium | 1985 |
Proenkephalin A fragments exhibit spinal and supraspinal opioid activity in vivo.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Muscle Contraction; Naloxone; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Urinary Bladder | 1985 |
Centrally administered beta-endorphin produces prolonged changes in delta-opioid ligand activity in vivo.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Intraventricular; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1986 |
Light microscopic autoradiographic localization of delta opioid receptors in the rat brain using a highly selective bis-penicillamine cyclic enkephalin analog.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microscopy; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Blockade of D-2 dopamine receptors strongly enhances the potency of enkephalins to inhibit dopamine-sensitive adenylate cyclase in rat neostriatum: involvement of delta- and mu-opioid receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclase Inhibitors; Animals; Benzazepines; Corpus Striatum; Cyclic AMP; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ergolines; Male; Morphine; Naloxone; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: studies with receptor selective agonists.
Topics: Analgesia; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Spinal Cord | 1986 |
Inhibition of mu and delta but not kappa opioid binding to membranes by Fab fragments from a monoclonal antibody directed against the opioid receptor.
Topics: Animals; Antibodies, Monoclonal; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Immunoglobulin Fab Fragments; In Vitro Techniques; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
In vivo evidence for spinal delta-opiate receptor operated antinociception.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1986 |
Ontogenesis of delta-opioid receptors in rat brain using [3H][D-Pen2,D-Pen5]enkephalin as a binding ligand.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Kinetics; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
[D-Pen2,D-Pen5]enkephalin (DPDPE): a delta-selective enkephalin with low affinity for mu 1 opiate binding sites.
Topics: Animals; Brain Chemistry; Cattle; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Pharmacological and anatomical evidence of selective mu, delta, and kappa opioid receptor binding in rat brain.
Topics: Animals; Autoradiography; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Continuous intrathecal opioid analgesia: tolerance and cross-tolerance of mu and delta spinal opioid receptors.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1987 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Morphine and enkephalins potently inhibit [3H]noradrenaline release from rat brain cortex synaptosomes: further evidence for a presynaptic localization of mu-opioid receptors.
Topics: Animals; Calcium; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptosomes; Tetrahydronaphthalenes | 1987 |
Naloxonazine and opioid-induced inhibition of reflex urinary bladder contractions.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Muscle Contraction; Naloxone; Rats; Receptors, Opioid; Reflex; Urinary Bladder | 1987 |
Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Motor Activity; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tegmentum Mesencephali | 1987 |
Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse.
Topics: Analgesia; Anesthesia, Spinal; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Modulation of rat brain opioid receptors by cannabinoids.
Topics: Animals; Cannabinoids; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spiperone | 1987 |
C57BL/6J-bgJ (beige) mice: differential sensitivity in the tail flick test to centrally administered mu- and delta-opioid receptor agonists.
Topics: Animals; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Effects of specific activation of mu-, delta- and kappa-opioid receptors on the secretion of luteinizing hormone and prolactin in the ovariectomized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Luteinizing Hormone; Ovariectomy; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Opioid receptor subtypes in the rat spinal cord: electrophysiological studies with mu- and delta-opioid receptor agonists in the control of nociception.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Oligopeptides; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Synaptic Transmission | 1987 |
Comparative pharmacological properties and functional coupling of mu and delta opioid receptor sites in human neuroblastoma SH-SY5Y cells.
Topics: Binding, Competitive; Cell Line; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electric Stimulation; Electrodes; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphinans; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
[D-Pen2,L-Pen5]enkephalin induced analgesia in the jimpy mouse: in vivo evidence for delta-receptor mediated analgesia.
Topics: Analgesics; Animals; Cerebrosides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Jimpy; Morphine; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta | 1987 |
Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain.
Topics: Animals; Autoradiography; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Use of augmented Lagrangians in the calculation of molecular conformations by distance geometry.
Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Mathematics; Molecular Conformation | 1988 |
Analgesia produced by centrally administered DAGO, DPDPE and U50488H in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Formaldehyde; Injections, Intraventricular; Male; Nociceptors; Pyrrolidines; Rats | 1988 |
A monoclonal antibody that inhibits opioid binding to rat brain membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antibodies, Monoclonal; Brain; Cattle; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme-Linked Immunosorbent Assay; Membranes; Narcotics; Pyrrolidines; Rats | 1988 |
Direct inhibition by opioid peptides of neurones located in the ventromedial nucleus of the guinea pig hypothalamus.
Topics: Action Potentials; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Neural Inhibition; Ventromedial Hypothalamic Nucleus | 1988 |
Contraversive circling induced by ventral tegmental microinjections of moderate doses of morphine and [D-Pen2, D-Pen5]enkephalin.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Morphine; Naloxone; Rats; Stereotyped Behavior; Tegmentum Mesencephali; Time Factors | 1988 |
1H-n.m.r. investigation of conformational features of cyclic, penicillamine-containing enkephalin analogs.
Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Protein Conformation; Structure-Activity Relationship; Thermodynamics | 1987 |
Mu and delta opioid ligands inhibit reflex contractions of the urinary bladder in the rat by different central mechanisms.
Topics: Animals; Biomechanical Phenomena; Central Nervous System; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Muscle Contraction; Rats; Rats, Inbred Strains; Reflex; Urinary Bladder | 1987 |
Comparison of conformational properties of linear and cyclic delta selective opioid ligands DTLET (Tyr-D X Thr-Gly-Phe-Leu-Thr) and DPLPE (Tyr-c[D X Pen-Gly-Phe-Pen]) by 1H n.m.r. spectroscopy.
Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Models, Molecular; Narcotics; Oligopeptides; Protein Conformation | 1987 |
Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Digestive System Physiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Narcotics; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1984 |
Evidence that naloxonazine produces prolonged antagonism of central delta opioid receptor activity in vivo.
Topics: Animals; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Naloxone; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1984 |
Electroencephalographic assessment of the role of delta receptors in opioid peptide - induced seizures.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures | 1984 |
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isomerism; Kinetics; Muscle Contraction; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1983 |
Cyclic penicillamine containing enkephalin analogs display profound delta receptor selectivities.
Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guinea Pigs; Hybrid Cells; Ileum; Male; Mice; Muscle Contraction; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1983 |
In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice.
Topics: Amino Acid Sequence; Analgesia; Animals; Antibodies; Benzeneacetamides; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunization, Passive; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
[D-Pen2,D-Pen5]enkephalin, a delta opioid agonist reduces endogenous aluminum content in the rat central nervous system.
Topics: Aluminum; Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Time Factors | 1995 |
Efficacy of peptide and nonpeptidic agonists at the cloned human delta opioid receptor.
Topics: Analgesics; Animals; Benzamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Opioid Peptides; Piperazines; Quinolines; Receptors, Opioid, delta; Recombinant Proteins | 1995 |
Reward shifts and motor responses following microinjections of opiate-specific agonists into either the core or shell of the nucleus accumbens.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 1995 |
Transgenic superoxide dismutase mice differ in opioid-induced analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Autoradiography; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Mice; Mice, Transgenic; Morphine; Nociceptors; Pyrrolidines; Superoxide Dismutase | 1995 |
Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons.
Topics: Amino Acid Sequence; Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; GTP-Binding Proteins; In Vitro Techniques; Molecular Sequence Data; Naloxone; Nerve Endings; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Reticular Formation; Substance P | 1993 |
14 alpha,14' beta-[Dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis (7,8-dihydromorphinone) and 14 alpha,14' beta-[dithiobis[(2-oxo-2,1- ethanediyl)imino]]bis[7,8-dihydro-N-(cyclopropylmethyl)normorphinone]: chemistry and opioid binding properties.
Topics: Alkylation; Analgesics; Animals; Benzeneacetamides; Cattle; Cell Membrane; Corpus Striatum; Disulfides; Dithiothreitol; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydromorphone; Kinetics; Molecular Structure; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tosylphenylalanyl Chloromethyl Ketone | 1994 |
Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes.
Topics: Aging; Analgesics; Animals; Carbazoles; Cell Membrane; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guinea Pigs; Indoles; Kinetics; Male; Naltrexone; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Species Specificity | 1994 |
Opioids inhibit the induction of nitric oxide synthase in J774 macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Induction; Lipopolysaccharides; Macrophages; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Pyrrolidines; Receptors, Opioid | 1995 |
Differential effects of 3-isobutyl-1-methylxanthine injected intrathecally or intracerebroventricularly on antinociception induced by opioids administered intracerebroventricularly in the mouse.
Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3',5'-Cyclic-AMP Phosphodiesterases; Analgesia; Animals; beta-Endorphin; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Spinal Cord | 1995 |
Antinociception and delta-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1995 |
Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of opioid subtypes.
Topics: Adenosine; Analgesics; Animals; Behavior, Animal; Caffeine; Calcium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nociceptors; Oligopeptides; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Synaptosomes | 1995 |
Novel deltorphin heptapeptide analogs with potent delta agonist, delta antagonist, or mixed mu antagonist/delta agonist properties.
Topics: Amino Acid Sequence; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Mice; Molecular Sequence Data; Narcotic Antagonists; Oligopeptides; Protein Conformation; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 1995 |
Lack of relationship between opioid-induced changes in fetal breathing and plasma glucose levels.
Topics: Animals; Blood Glucose; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetus; Gases; Lactates; Lactic Acid; Morphine; Respiration | 1995 |
Regional haemodynamic effects of mu-, delta-, and kappa-opioid agonists microinjected into the hypothalamic paraventricular nuclei of conscious, unrestrained rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antihypertensive Agents; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hemodynamics; Hindlimb; Laser-Doppler Flowmetry; Male; Mesenteric Arteries; Microinjections; Paraventricular Hypothalamic Nucleus; Pyrrolidines; Rats; Rats, Inbred WKY; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Renal Artery; Tachycardia; Vasoconstriction; Vasodilation | 1995 |
Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Amino Acid Sequence; Cell Line; Colforsin; Culture Media, Conditioned; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Receptors, Opioid, delta | 1995 |
Tyrosine-iodination converts the delta-opioid peptide antagonist TIPP to an agonist.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain Neoplasms; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Iodine; Mice; Molecular Sequence Data; Molecular Weight; Narcotic Antagonists; Neuroblastoma; Oligopeptides; Receptors, Opioid, delta; Spectrometry, Mass, Fast Atom Bombardment; Tetrahydroisoquinolines; Tumor Cells, Cultured; Tyrosine | 1995 |
Localization of Mu and delta opioid receptors to anterior cingulate afferents and projection neurons and input/output model of Mu regulation.
Topics: Afferent Pathways; Analgesics; Animals; Binding Sites; Caudate Nucleus; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gyrus Cinguli; Male; Models, Neurological; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Identification of the amino acid residues involved in selective agonist binding in the first extracellular loop of the delta- and mu-opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Asparagine; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Lysine; Molecular Sequence Data; Morphine; Mutagenesis, Site-Directed; Protein Structure, Secondary; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Proteins | 1995 |
Effects of a highly selective nonpeptide delta opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice.
Topics: Analgesics; Animals; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Nociceptors; Oligopeptides; Quinolines; Receptors, Opioid, delta | 1995 |
Human delta opioid receptor: a stable cell line for functional studies of opioids.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins | 1995 |
Ventral tegmental injections of a selective mu or delta opioid enhance feeding in food-deprived rats.
Topics: Animals; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Food Deprivation; Male; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors; Ventral Tegmental Area | 1995 |
Modulation of free intracellular calcium levels [(Ca++)i] in brain and spinal cord of morphine-tolerant rats and mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Calcium; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fura-2; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Subcellular Fractions; Synaptosomes | 1995 |
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
Contrasting actions of intrathecal U50,488H, morphine, or [D-Pen2, D-Pen5] enkephalin or intravenous U50,488H on the visceromotor response to colorectal distension in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum | 1995 |
Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Colon; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum | 1995 |
Peripheral opioid modulation of pain and inflammation in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Inflammation; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Narcotics; Pain; Pyrrolidines; Rats; Receptors, Opioid | 1995 |
mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle.
Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Aorta; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
[Interaction between opiate subtypes and serotonin in suppressing noxiously evoked activity of WDR neurons].
Topics: Animals; Cats; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin; Spinal Cord | 1995 |
Coupling of the cloned mu-opioid receptor with the omega-conotoxin-sensitive Ca2+ current in NG108-15 cells.
Topics: Animals; Calcium Channels; Cloning, Molecular; DNA, Complementary; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Expression; Glioma; GTP-Binding Proteins; Hybrid Cells; Neuroblastoma; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Rats; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.
Topics: Analgesics; Animals; beta-Adrenergic Receptor Kinases; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Humans; Mice; Phosphorylation; Protein Kinase C; Receptors, Opioid, delta; Tetradecanoylphorbol Acetate | 1995 |
Delta, mu and kappa opioid receptor agonists inhibit dopamine overflow in rat neostriatal slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Neostriatum; Nomifensine; Oligopeptides; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Opioid agonists modulate release of neurotransmitters in bovine trachealis muscle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Cattle; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Muscle Contraction; Neurotransmitter Agents; Pyrrolidines; Receptors, Opioid; Trachea | 1995 |
Delta opioid agonists inhibit proliferation of highlypurified murine CD4+ and CD8+ T-cells.
Topics: Analgesics; Animals; CD4 Antigens; CD8 Antigens; Cell Division; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; T-Lymphocytes | 1995 |
Spinal GABA receptors mediate brain delta opioid analgesia in Swiss Webster mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Heroin; Injections, Spinal; Male; Mice; Morphine; Pain Measurement; Receptors, GABA; Receptors, Opioid, delta; Spinal Cord | 1995 |
Expression of functional delta opioid receptors in Xenopus oocytes.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Glioma; Hybrid Cells; Isoproterenol; Mice; Naltrexone; Neuroblastoma; Oocytes; Poly A; Rats; Receptors, Opioid, delta; RNA; RNA, Messenger; Xenopus laevis | 1993 |
Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Axonal Transport; beta-Endorphin; Biological Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Ligation; Male; Naloxone; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve | 1993 |
Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Analgesics; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homovanillic Acid; Hydroxyindoleacetic Acid; Limbic System; Male; Microinjections; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali | 1993 |
Opioid inhibition of rapid eye movement sleep by a specific mu receptor agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cats; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Neprilysin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Reticular Formation; Sleep, REM; Wakefulness | 1995 |
Brain sites involved in delta-opioid receptor-mediated actions.
Topics: Amino Acid Sequence; Animals; Autoradiography; Basal Ganglia Diseases; Brain; Brain Mapping; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucose; Injections, Intraventricular; Male; Molecular Sequence Data; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues.
Topics: Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Oligopeptides; Receptors, Opioid, delta; Recombinant Fusion Proteins | 1994 |
Differential cross-tolerance between analgesia produced by alpha 2-adrenoceptor agonists and receptor subtype selective opioid treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics; Animals; Binding Sites; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Xylazine | 1995 |
Opioid effects on spinal [3H]5-hydroxytryptamine release are not related to their antinociceptive action.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Isotope Labeling; Male; Molecular Sequence Data; Naltrexone; Narcotics; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin; Somatostatin; Spinal Cord; Synaptic Transmission; Synaptosomes | 1995 |
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Species Specificity; Spinal Cord | 1995 |
The contribution of delta 1- and delta 2-opioid receptors to hypoxia-induced pial artery dilation in the newborn pig.
Topics: Animals; Animals, Newborn; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypoxia; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pia Mater; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Behavioral and neurochemical effects of opioids in the paramedian midbrain tegmentum including the median raphe nucleus and ventral tegmental area.
Topics: Animals; Brain Chemistry; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Male; Morphine; Motor Activity; Naloxone; Neurotransmitter Agents; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Tegmental Area | 1995 |
Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues.
Topics: Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Molecular Sequence Data; Oligopeptides; Radioligand Assay; Receptors, Opioid, delta | 1994 |
Investigating the effects of opioid drugs on electrocortical activity using wavelet transform.
Topics: Animals; Cerebral Cortex; Data Interpretation, Statistical; Electroencephalography; Embryonic and Fetal Development; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Morphine; Pregnancy; Receptors, Opioid; Sheep; Time Factors | 1995 |
Action of opioid peptides on the rat adrenal cortex: stimulation of steroid secretion through a specific mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Cortex; Aldosterone; Analgesics; Animals; beta-Endorphin; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Opioid Peptides; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Ventral tegmental area opioid mechanisms and modulation of ingestive behavior.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Male; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Ventral Tegmental Area | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Barium; Calcium Channels; Cell Line; Cloning, Molecular; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Transport; Membrane Potentials; Morphine; Naloxone; Pertussis Toxin; Pituitary Gland; Rats; Receptors, Opioid, mu; Somatostatin; Transfection; Virulence Factors, Bordetella | 1995 |
Electrophysiological effects of opioid receptor selective agonists on guinea-pig papillary muscle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Specific N- or C-terminus modified dynorphin and beta-endorphin peptides can selectively block excitatory opioid receptor functions in sensory neurons and unmask potent inhibitory effects of opioid agonists.
Topics: Action Potentials; Animals; beta-Endorphin; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Mice; Morphine; Neurons; Receptors, Opioid, delta | 1995 |
Evidence for differential modulation of mu-opioid receptor-mediated antinociceptive and antitussive activities by spleen-derived factor(s) from diabetic mice.
Topics: Analgesics; Animals; Antitussive Agents; Biological Factors; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Receptors, Opioid, delta; Receptors, Opioid, mu; Spleen | 1994 |
ACTH-(1-24) blocks the decompensatory phase of the haemodynamic response to acute hypovolaemia in conscious rabbits.
Topics: Animals; Cosyntropin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epinephrine; Hemodynamics; Hydrocortisone; Nitroprusside; Propranolol; Rabbits; Scopolamine; Shock | 1995 |
Single diastereomeric desaminotyrosylalanyl tetra- and heptapeptides with opioid antagonistic activity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Molecular Sequence Data; Molecular Structure; Morphine; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Receptors, Opioid; Stereoisomerism; Tetrahydroisoquinolines; Vas Deferens | 1995 |
Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes.
Topics: Analgesics; Animals; Base Sequence; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Molecular Sequence Data; Morphine; Oligonucleotides, Antisense; Rats; Receptors, Opioid, delta | 1995 |
Delta-opioid peptide receptors in muscles from obese diabetic and normal mice.
Topics: Analgesics; Animals; Autoradiography; beta-Endorphin; Binding, Competitive; Cell Membrane; Diabetes Mellitus; Diabetes Mellitus, Type 2; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Iodine Radioisotopes; Mice; Mice, Obese; Muscle, Skeletal; Obesity; Oligopeptides; Receptors, Opioid, delta; Reference Values | 1995 |
Analgesic effect of two calcitonins and in vitro interaction with opioids.
Topics: Analgesics; Animals; Benzomorphans; Calcitonin; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Narcotics; Pain Measurement; Pain Threshold; Rabbits; Rats; Rats, Wistar | 1995 |
Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium | 1995 |
Radioligand-binding study of noribogaine, a likely metabolite of ibogaine.
Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; In Vitro Techniques; Kinetics; Naloxone; Pyrrolidines; Radioligand Assay; Receptors, Opioid | 1995 |
An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Injections, Intraventricular; Male; Mice; Models, Molecular; Molecular Sequence Data; Naloxone; Opioid Peptides; Pain Measurement; Protein Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism | 1994 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Role of nitric oxide/cyclic GMP in i.c.v. administered beta-endorphin- and (+)-cis-dioxolane-induced antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Arginine; beta-Endorphin; Cyclic GMP; Dioxolanes; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemoglobins; Injections, Intraventricular; Male; Methylene Blue; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Nitric Oxide; Nitroarginine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1994 |
Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors.
Topics: Analgesics; Animals; Autoradiography; Brain; Brain Chemistry; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Up-Regulation | 1994 |
Differential antagonism by MK-801 against antinociception induced by opioid receptor agonists administered supraspinally in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 1994 |
Characterization of functional opioid delta receptors in a luteinizing hormone-releasing hormone-producing neuronal cell line.
Topics: Animals; Cell Line; Cell Membrane; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Mice; Neurons; Receptors, Opioid, delta | 1995 |
Mesoaccumbens dopamine-opiate interactions in the control over behaviour by a conditioned reinforcer.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Dextroamphetamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Ergolines; Injections; Male; Nucleus Accumbens; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid; Tegmentum Mesencephali | 1994 |
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin | 1994 |
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice.
Topics: Analgesics; Animals; Benzylidene Compounds; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Comparison of delta opiate receptor agonist induced reward and motor effects between the ventral pallidum and dorsal striatum.
Topics: Animals; Caudate Nucleus; Conditioning, Operant; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Rats; Receptors, Opioid, delta; Reward; Self Stimulation | 1994 |
[D-Pen2-D-Pen5]enkephalin, a delta opioid agonist, given intracerebroventricularly in the mouse produces antinociception through medication of spinal GABA receptors.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GABA Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Injections, Intraventricular; Injections, Spinal; Isonicotinic Acids; Male; Mice; Mice, Inbred ICR; Pain Measurement; Receptors, GABA; Receptors, Opioid, delta; Spinal Cord | 1994 |
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice.
Topics: Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Potassium Channels; Pyrroles; Receptors, Opioid, mu; Tetraethylammonium Compounds | 1994 |
Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Anesthesia, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Halothane; Heart Rate; Hot Temperature; Injections, Spinal; Male; Morphine; Nalbuphine; Nociceptors; Pain Threshold; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Reflex; Thiophenes | 1995 |
Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medulla.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Medulla Oblongata; Molecular Sequence Data; Oligopeptides; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Long-term sensitization to the behavioral effects of naltrexone is associated with regionally specific changes in the number of mu and delta opioid receptors in rat brain.
Topics: Animals; Behavior, Animal; Brain; Cerebral Cortex; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mesencephalon; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Rhombencephalon; Salivation; Tritium | 1995 |
Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Codeine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucuronates; Guinea Pigs; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1995 |
Effects of the delta-opioid agonist, [D-Pen2,D-Pen5]-enkephalin, on fetal lamb EEG.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Fetus; Injections, Intraventricular; Naltrexone; Narcotic Antagonists; Pregnancy; Receptors, Opioid, delta; Sheep | 1994 |
Functional couplings of the delta- and the kappa-opioid receptors with the G-protein-activated K+ channel.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Base Sequence; Cloning, Molecular; Codon; DNA Primers; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kinetics; Membrane Potentials; Mice; Molecular Sequence Data; Naloxone; Oocytes; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Xenopus laevis | 1995 |
Dexamethasone-induced selective inhibition of the central mu opioid receptor: functional in vivo and in vitro evidence in rodents.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dexamethasone; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Mice; Morphine; Oligopeptides; Pain Measurement; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu | 1994 |
Electrophysiological demonstration of mu, delta and kappa opioid receptors in the ventral pallidum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Amino Acid Sequence; Animals; Brain Mapping; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Globus Pallidus; Iontophoresis; Male; Molecular Sequence Data; Morphine; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Location of regions of the opioid receptor involved in selective agonist binding.
Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Narcotics; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins | 1995 |
Supraspinal delta opioid receptor mRNA levels are not altered in [D-Ala2]deltorphin II tolerant mice.
Topics: Animals; DNA, Complementary; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Situ Hybridization; Injections, Intraventricular; Male; Mice; Pain Measurement; Receptors, Opioid, delta; RNA Probes; RNA, Messenger; Spinal Cord | 1994 |
TIPP[psi], a highly selective delta ligand.
Topics: Animals; Binding, Competitive; Cattle; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ligands; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thalamus | 1994 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment.
Topics: Calcium; Cell Differentiation; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Membrane Potentials; Neuroblastoma; Pertussis Toxin; Somatostatin; Tretinoin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Gx/z and Gi2 transducer proteins on mu/delta opioid-mediated supraspinal antinociception.
Topics: Amino Acid Sequence; Analgesics, Opioid; Analysis of Variance; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Immune Sera; Male; Mice; Molecular Sequence Data; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Receptor-selective opioid peptides fail to affect behavioral responses induced by a low dose of apomorphine in the mouse.
Topics: Analgesics; Animals; Apomorphine; Behavior, Animal; Benzazepines; Dopamine Agents; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Grooming; Male; Mice; Mice, Inbred Strains; Motor Activity; Peptide Fragments; Receptors, Opioid; Stereotyped Behavior | 1993 |
Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Barium Compounds; Cadmium; Carbachol; Chlorides; Computer Simulation; Dynorphins; Electrophysiology; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Models, Neurological; Naloxone; Narcotics; Neurons; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Opioid actions on rat anterior cingulate cortex neurons in vitro.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glutamates; Glutamic Acid; Gyrus Cinguli; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Neurotransmitter Agents; Rats; Receptors, Opioid; Somatostatin; Synapses; Synaptic Transmission | 1994 |
Adaptive changes in rat striatal preproenkephalin expression and dopamine-opioid interactions upon chronic haloperidol treatment during different developmental stages.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Embryonic and Fetal Development; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Fetus; Gene Expression; Guanylate Cyclase; Haloperidol; In Situ Hybridization; Maternal-Fetal Exchange; Pregnancy; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger | 1994 |
Effect of peptidases at the blood brain barrier on the permeability of enkephalin.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Cattle; CD13 Antigens; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Molecular Sequence Data; Neprilysin; Peptidyl-Dipeptidase A | 1994 |
Dissimilar efficacy of opioids to produce mu-mediated analgesia: role of Gx/z and Gi2 transducer proteins.
Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Cell Membrane; Cerebral Ventricles; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Immunoglobulin G; Injections, Intraventricular; Kinetics; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Pain; Peptide Fragments; Receptors, Opioid, mu; Signal Transduction | 1994 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Antisense oligodeoxynucleotide to a delta-opioid receptor selectively blocks the spinal antinociception induced by delta-, but not mu- or kappa-opioid receptor agonists in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger | 1994 |
Mastoparan reduces the supraspinal analgesia mediated by mu/delta-opioid receptors in mice.
Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Male; Mice; Molecular Sequence Data; Peptides; Receptors, Opioid; Wasp Venoms | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Differential regulation of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells.
Topics: Amino Acid Sequence; Cell Differentiation; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1994 |
Characterization of opioid receptors in the Mongolian gerbil cerebellum.
Topics: Animals; Autoradiography; Benzeneacetamides; Binding Sites; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gerbillinae; Guanylyl Imidodiphosphate; In Vitro Techniques; Narcotics; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu | 1994 |
1-Aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance.
Topics: Amino Acids; Amino Acids, Cyclic; Analgesia; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Effects of mu-, delta- and kappa-agonists on isolated right atria of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Propranolol; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides | 1994 |
Differential modulation of behavioral responses by [D-Ala2, NMePhe4, Gly-ol]enkephalin, [D-Ala2] deltorphin II and [D-Pen2, L-Pen5]enkephalin in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Naltrexone; Oligopeptides | 1994 |
Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Apamin; Arginine; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Neural Inhibition; Neurotransmitter Agents; Nitric Oxide; Nitroarginine; omega-Conotoxin GVIA; Peptides; Suramin | 1994 |
Lack of involvement of delta-opioid receptor in mediating physical dependence at the hypothalamus-pituitary-adrenocortical (HPA) axis in the rat.
Topics: Animals; Corticosterone; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Opioid-Related Disorders; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
The effect of naltrindole on spinal and supraspinal delta opioid receptors and analgesia.
Topics: Analgesia; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Kinetics; Male; Mice; Naltrexone; Pain Measurement; Receptors, Opioid, delta; Spinal Cord | 1994 |
In vivo treatment with mu and delta, but not kappa-selective opioid agonists reduces [3H]spiperone binding to the guinea-pig striatum: autoradiographic evidence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Brain; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Male; Morphine; Organ Specificity; Pyrrolidines; Receptors, Dopamine D2; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiperone; Tritium | 1994 |
The effects of protection by D-Pen2-D-Pen5-enkephalin or D-Ala2-NMePhe4-Gly-ol-enkephalin against beta-chlornaltrexamine in the spinal cord on the antinociception induced by beta-endorphin administered intracerebroventricularly in the mouse.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Spinal Cord | 1994 |
Opioid receptors modulate diverse types of calcium channels in the nucleus tractus solitarius of the rat.
Topics: Animals; Calcium; Calcium Channels; Cell Separation; Differential Threshold; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; GTP-Binding Proteins; Medulla Oblongata; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1994 |
Selective antagonism of opioid analgesia by a sigma system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Haloperidol; Male; Mice; Morphine; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, sigma; Species Specificity | 1994 |
Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Macaca mulatta; Male; Narcotics; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1994 |
Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density?
Topics: Adenylyl Cyclase Inhibitors; Animals; Base Sequence; CHO Cells; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Sequence Data; Receptors, Opioid, delta; RNA, Messenger; Transfection | 1994 |
The functional role of opioid receptors in acetylcholine release in the rat adrenal medulla.
Topics: Acetylcholine; Adrenal Medulla; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microdialysis; Morphine; Nerve Endings; Physostigmine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Splanchnic Nerves | 1994 |
Effect of omega-conotoxin and verapamil on antinociceptive, behavioural and thermoregulatory responses to opioids in the rat.
Topics: Analgesia; Animals; Behavior, Animal; Body Temperature Regulation; Brain; Calcium Channel Blockers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotics; omega-Conotoxin GVIA; Peptides; Rats; Rats, Sprague-Dawley; Verapamil | 1994 |
Selective inhibition of [D-Ala2, Glu4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor.
Topics: Analgesics; Animals; Base Sequence; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Nociceptors; Oligonucleotides, Antisense; Oligopeptides; Pyrrolidines; Receptors, Opioid, delta | 1994 |
Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Methyltyrosines; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligopeptides; Peptides; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship | 1994 |
Opioids decrease high-voltage activated calcium currents in acutely dissociated neostriatal neurons.
Topics: Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Neostriatum; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat.
Topics: Aging; Analgesics; Analysis of Variance; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Pain; Rats; Rats, Inbred F344; Spine | 1994 |
Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Cell Differentiation; Colforsin; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Neuroblastoma; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Tumor Cells, Cultured | 1994 |
Streptozotocin-induced diabetes selectively enhances antinociception mediated by delta 1- but not delta 2-opioid receptors.
Topics: Analgesia; Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin | 1994 |
Effects of mu and delta opioid receptor agonists and antagonists on absence epilepsy in WAG/Rij rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epilepsy, Absence; Male; Naloxone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Comparative study of the effects of mu, delta and kappa opioid agonists on 3H-dopamine uptake in rat striatum and nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Synaptosomes | 1994 |
Implantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance.
Topics: Animals; beta-Endorphin; Cell Line; Cell Transplantation; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoproterenol; Male; Mice; Mice, Inbred ICR; Narcotics; Nociceptors; Pituitary Neoplasms; Protein Precursors; Spinal Cord; Transfection; Tumor Cells, Cultured | 1994 |
Restraint changes pentobarbital-induced sleeping time in rats: evidence that arousal is modulated by brain corticotropin-releasing hormone and opioid in stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arousal; Brain; Cerebral Ventricles; Corticotropin-Releasing Hormone; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Pentobarbital; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Restraint, Physical; Sleep; Stress, Psychological | 1994 |
Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH.
Topics: Cell Line; Dextrorphan; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Levorphanol; Morphine; Naloxone; Narcotics; Neuroblastoma; Norepinephrine; Receptors, Opioid; Tritium; Tumor Cells, Cultured | 1994 |
Treatment with antisense oligodeoxynucleotide to the opioid delta receptor selectively inhibits delta 2-agonist antinociception.
Topics: Analgesics; Animals; Base Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Nociceptors; Oligonucleotides, Antisense; Oligopeptides; Reaction Time; Receptors, Opioid, delta | 1994 |
Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cerebral Ventricles; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression; GTP-Binding Proteins; In Situ Hybridization; Infusions, Parenteral; Male; Naltrexone; Narcotics; Oligonucleotide Probes; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius.
Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Benzeneacetamides; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Medulla Oblongata; Potassium Channels; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synaptic Transmission | 1993 |
Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Cell Compartmentation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Mathematics; Neuroblastoma; Oxotremorine; Parasympathomimetics; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Opioid; Signal Transduction | 1993 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Animals; Antibodies; Cell Membrane; Clone Cells; Corpus Striatum; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Kinetics; Membrane Proteins; Neuroblastoma; Pertussis Toxin; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Cyclic AMP mediates mu and delta, but not kappa opioid analgesia in the spinal cord of the rat.
Topics: Analgesia; Analgesics; Animals; Bucladesine; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Pain; Peptide Fragments; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1993 |
Opioid actions on neurons of rat lateral amygdala in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Amino Acids; Amygdala; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; GABA-A Receptor Antagonists; In Vitro Techniques; Molecular Sequence Data; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pyrrolidines; Rats; Somatostatin; Synapses | 1993 |
Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum: role of opiates and 5-hydroxytryptamine.
Topics: Analgesics; Animals; Atropine; Autonomic Nervous System; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Rats; Rats, Wistar; Serotonin; Synaptic Transmission; Tetrodotoxin | 1993 |
Cloning and expression of a cDNA for the rat kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Base Sequence; Cells, Cultured; Cloning, Molecular; DNA; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sequence Homology, Amino Acid | 1993 |
Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Immunoglobulin G; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Morphine; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Protein Binding; Reaction Time; Receptors, Opioid, delta | 1994 |
Delta-1 opioid agonist acutely increases hypoxic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Benzylidene Compounds; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypoxia; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid, delta | 1994 |
Identification of mechanisms and sites of actions of mu and delta opioid receptor activation in the canine intestine.
Topics: Amino Acid Sequence; Animals; Dogs; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Nitric Oxide; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Vasoactive Intestinal Peptide | 1994 |
Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Characterization of [3H]naltrindole binding to delta opioid receptors in mouse brain and mouse vas deferens: evidence for delta opioid receptor heterogeneity.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Vas Deferens | 1994 |
Effect of ambient temperature on the ability of mu-, kappa- and delta-selective opioid agonists to modulate thermoregulatory mechanisms in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature Regulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Narcotics; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Temperature | 1994 |
Antinociception induced by intrathecal coadministration of selective adenosine receptor and selective opioid receptor agonists in mice.
Topics: Adenosine; Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Narcotics; Phenethylamines; Receptors, Opioid; Receptors, Purinergic P1 | 1994 |
Selective opioid dipeptides.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cell Membrane; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Isoquinolines; Kinetics; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Narcotics; Oligopeptides; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Tetrahydroisoquinolines | 1994 |
mu-Opioid agonists inhibit spinal trigeminal substantia gelatinosa neurons in guinea pig and rat.
Topics: Animals; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Neural Inhibition; Neurons; Potassium; Rats; Rats, Wistar; Substantia Gelatinosa; Synaptic Transmission; Trigeminal Nucleus, Spinal | 1994 |
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry.
Topics: Analgesia; Analgesics; Animals; Conditioning, Classical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immune Sera; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 1994 |
Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1994 |
The antinociceptive and motivational effects of intranigral injection of opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Morphine; Morphine Derivatives; Motivation; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reward; Stereotaxic Techniques; Substantia Nigra; Time Factors | 1993 |
mu-Opioid receptors modulate noradrenaline release from the rat hippocampus as measured by brain microdialysis.
Topics: Analgesics; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extracellular Space; GTP-Binding Proteins; Hippocampus; Male; Microdialysis; Morphine; Naltrexone; Nerve Endings; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1994 |
Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid, delta | 1994 |
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Fura-2; Glioma; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Microscopy, Fluorescence; Naloxone; Narcotics; Neuroblastoma; Pyrrolidines; Rats; Tumor Cells, Cultured | 1994 |
Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats.
Topics: Analgesics; Analysis of Variance; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Motor Activity; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Stereotyped Behavior; Ventral Tegmental Area | 1994 |
Selective loss of delta opioid analgesia and binding by antisense oligodeoxynucleotides to a delta opioid receptor.
Topics: Adenylyl Cyclases; Analgesia; Animals; Base Sequence; Binding Sites; Cell Line; Colforsin; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Receptors, Opioid, delta; Tritium | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Tyrosine phosphorylation of a 58 kDa protein induced by morphine in SK-N-SH cells.
Topics: Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Kinetics; Molecular Weight; Morphine; Naloxone; Nerve Tissue Proteins; Pertussis Toxin; Phosphorylation; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Tyrosine; Virulence Factors, Bordetella | 1994 |
Blockade of U50,488H analgesia by antisense oligodeoxynucleotides to a kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Binding Sites; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Injections, Spinal; Molecular Sequence Data; Oligonucleotides, Antisense; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Involvement of glutamate receptors in the striatal enkephalin-induced dopamine release.
Topics: Analgesics; Analysis of Variance; Animals; Corpus Striatum; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
[L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity.
Topics: Amino Acid Sequence; Analgesia; Analgesics; Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 1994 |
Mouse brain opioid receptor identification by direct ultraviolet photoaffinity labeling.
Topics: Affinity Labels; Animals; Binding Sites; Dithiothreitol; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Naloxone; Receptors, Opioid; Tritium; Tyrosine; Ultraviolet Rays | 1993 |
Effect of electroconvulsive shock treatment on the opioid-mediated inhibition of serotonin release in rat hippocampal slices.
Topics: Analgesics; Animals; Electroshock; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serotonin | 1993 |
[The influence of DPDPE on intracellular free calcium concentration induced by Bt2 cAMP and phorbol ester].
Topics: Calcium-Transporting ATPases; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1993 |
Partial antinociceptive cross-tolerance to intracerebroventricular beta-endorphin in mice tolerant to systemic morphine.
Topics: Analgesics; Animals; beta-Endorphin; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Norepinephrine; Pain Measurement; Serotonin | 1993 |
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.
Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis | 1993 |
Effects of intracerebroventricular administration of beta-funaltrexamine on [3H]DAMGO binding to rat brain sections.
Topics: Animals; Autoradiography; Brain Mapping; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu | 1993 |
Modification of G protein-coupled functions by low-pH pretreatment of membranes from NG108-15 cells: increase in opioid agonist efficacy by decreased inactivation of G proteins.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Triphosphate; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mice; Rats; Receptors, Opioid; Sodium; Tritium; Tumor Cells, Cultured | 1993 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |
Comparison of the membrane-bound states of two structurally similar delta-selective opioid peptides by transferred nuclear Overhauser effect spectroscopy and molecular modeling.
Topics: Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Ligands; Light; Liposomes; Magnetic Resonance Spectroscopy; Models, Molecular; Receptors, Opioid, delta; Scattering, Radiation; Solutions; Structure-Activity Relationship; Thermodynamics; Viscosity | 1993 |
Ventral mesencephalic delta opioid receptors are involved in modulation of basal mesolimbic dopamine neurotransmission: an anatomical localization study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Basal Metabolism; Diffusion; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Limbic System; Male; Nucleus Accumbens; Rats; Receptors, Opioid, delta; Synaptic Transmission; Ventral Tegmental Area | 1993 |
Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Midazolam; Molecular Sequence Data; Naltrexone; Pentylenetetrazole; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1993 |
Differential antagonism by naltrindole-5'-isothiocyanate on [3H]DSLET and [3H]DPDPE binding to striatal slices of mice.
Topics: Analgesics; Animals; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Male; Mice; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Tritium | 1993 |
Molecular mechanism of delta-selectivity of indole analogs of nonpeptide opioids.
Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
delta-Opioid receptor-mediated regulation of central dopaminergic neurons in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurons; Rats; Receptors, Opioid, delta | 1993 |
Characterization and localization of delta opioid binding sites in the bovine pineal gland.
Topics: Animals; Autoradiography; Binding Sites; Cattle; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Naloxone; Pineal Gland; Receptors, Opioid, delta | 1993 |
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Restraint, Physical; Stomach Ulcer; Stress, Physiological | 1993 |
DAMGO ([D-Ala2,NMePhe4,Gly-ol]enkephalin), but not DPLPE ([D-Pen2,L- Pen5]enkephalin), specifically inhibits methamphetamine-induced behavioral responses in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Methamphetamine; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists | 1993 |
Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro.
Topics: Analgesics; Animals; Animals, Newborn; Calcium Channels; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Microelectrodes; Potassium Channels; Presynaptic Terminals; Rats; Receptors, Opioid, mu; Receptors, Presynaptic; Second Messenger Systems; Synapses | 1993 |
Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Benzylidene Compounds; Caudate Nucleus; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity.
Topics: Adenylyl Cyclases; Analgesics; Animals; Caudate Nucleus; Cocaine; Cyclic AMP; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Nucleus Accumbens; Putamen; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values | 1993 |
Effect of diabetes on the antinociceptive effect of beta-endorphin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Reference Values | 1993 |
Beta-endorphin is a potent inhibitor of thymidine incorporation into DNA via mu- and kappa-opioid receptors in fetal rat brain cell aggregates in culture.
Topics: Animals; beta-Endorphin; Brain; Cell Aggregation; Cells, Cultured; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fetus; Kinetics; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thymidine; Tritium | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens.
Topics: Animals; Benzylidene Compounds; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Thiocyanates; Vas Deferens | 1993 |
mu and delta opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells.
Topics: Affinity Labels; Azides; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Immunosorbent Techniques; Neuroblastoma; Pertussis Toxin; Photochemistry; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Binding of 3H-D-Pen2-D-Pen5-enkephalin to brain regions and spinal cord membranes of spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: Animals; Blood Pressure; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hypertension; Membranes; Protein Binding; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid, delta; Reference Values; Spinal Cord; Tritium | 1993 |
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat.
Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord.
Topics: Analgesics; Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Spinal Cord | 1993 |
Effect of opioid receptor subtype-selective agonists on purinergic and adrenergic components of neurogenic contractions of mouse vas deferens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Receptors, Adrenergic; Receptors, Opioid; Receptors, Purinergic; Sympathetic Nervous System; Vas Deferens | 1993 |
Opioid receptors in midbrain dopaminergic regions of the rat. II. Kappa and delta receptor autoradiography.
Topics: Animals; Autoradiography; Benzeneacetamides; Densitometry; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Image Processing, Computer-Assisted; Male; Mesencephalon; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Substantia Nigra; Tegmentum Mesencephali | 1993 |
Autoradiographic evidence for decrease in binding of mu- and delta-opioid receptors after subchronic [D-Ala2,D-Leu5]enkephalin treatment in rats.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Caudate Nucleus; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ligands; Male; Mesencephalon; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Thermodynamic parameters for [D-Pen2,5]enkephalin at delta-opioid receptors in the mouse isolated vas deferens.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Naltrexone; Receptors, Opioid, delta; Temperature; Thermodynamics; Vas Deferens | 1993 |
Immunomodulation of human T cell responses with receptor selective enkephalins.
Topics: Adjuvants, Immunologic; Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; In Vitro Techniques; Leprosy; Lymphocyte Activation; Molecular Sequence Data; Opioid Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Receptors, Opioid, mu; Rosette Formation; T-Lymphocytes; Tuberculosis, Pulmonary | 1993 |
Characterization of the bioactive form and molecular determinants of recognition of cyclic enkephalin peptides at the delta-opioid receptor.
Topics: Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Peptides, Cyclic; Protein Conformation; Receptors, Opioid, delta; Thermodynamics | 1993 |
Differential modulation of mu-opioid receptor-mediated antitussive activity by delta-opioid receptor agonists in mice.
Topics: Animals; Antitussive Agents; Cough; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
mu and delta opioid agonists at low concentrations decrease voltage-dependent K+ currents in F11 neuroblastoma x DRG neuron hybrid cells via cholera toxin-sensitive receptors.
Topics: Animals; Cholera Toxin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Hybrid Cells; Membrane Potentials; Neuroblastoma; Neurons; Pertussis Toxin; Potassium Channels; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1993 |
Co-localization of mu and delta opioid receptors on SK-N-SH cells detected by fluorescence microscopy using labeled anti-idiotypic antibodies.
Topics: Antibodies, Anti-Idiotypic; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Microscopy, Fluorescence; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Evidence for mu-, delta-, and kappa-opioid receptors in a human neuroblastoma cell line.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Binding, Competitive; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Tritium; Tumor Cells, Cultured | 1993 |
Suppression by [D-Pen2, D-Pen5]enkephalin on cyclic AMP dependent protein kinase-induced, but not protein kinase C-induced increment of intracellular free calcium in NG108-15 cells.
Topics: Analgesics; Animals; Bucladesine; Calcium; Calcium Channels; Colforsin; Depression, Chemical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Hybrid Cells; Intracellular Fluid; Mice; Neuroblastoma; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, Opioid, delta; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Antinociception produced by receptor selective opioids. Modulation of supraspinal antinociceptive effects by spinal opioids.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 1993 |
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1993 |
Feeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Male; Pyrrolidines; Rats; Receptors, Opioid | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
Behavioral effects of opioid peptide agonists DAMGO, DPDPE, and DAKLI on locomotor activities.
Topics: Amino Acid Sequence; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Motor Activity; Peptides; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior | 1993 |
Reconstitution of a purified mu-opioid binding protein in liposomes: selective, high affinity, GTP gamma S-sensitive mu-opioid agonist binding is restored.
Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Cholic Acids; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Liposomes; Morphine; Naloxone; Narcotics; Receptors, Opioid, mu | 1993 |
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis.
Topics: Analgesics; Animals; Benzeneacetamides; Dialysis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; Male; Micromanipulation; Morphine; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin | 1993 |
Quantitative autoradiographic demonstration of changes in binding to delta opioid, but not mu or kappa receptors, in chick forebrain 30 minutes after passive avoidance training.
Topics: Animals; Autoradiography; Avoidance Learning; Chickens; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Filtration; ortho-Aminobenzoates; Prosencephalon; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Identification, partial characterization, and hypothalamic distribution of kappa, mu, and delta opioid receptors in a passerine songbird (Junco hyemalis).
Topics: Animals; Autoradiography; Binding, Competitive; Birds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Feeding Behavior; Hypothalamic Area, Lateral; Hypothalamus; In Vitro Techniques; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thermodynamics; Ventromedial Hypothalamic Nucleus | 1993 |
Pseudoirreversible binding characteristics of [D-Ala2,Glu4]deltorphin and its Cys4 substituted derivative to delta-opioid receptors.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Dithiothreitol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Injections, Intraventricular; Male; Membranes; Mice; Oligopeptides; Radioligand Assay; Receptors, Opioid, delta | 1993 |
Opioid actions at mu and delta receptors in the rat dentate gyrus in vitro.
Topics: Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
In vitro potency, affinity and agonist efficacy of highly selective delta opioid receptor ligands.
Topics: Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1993 |
Evidence for delta opioid receptor subtypes in rat spinal cord: studies with intrathecal naltriben, cyclic[D-Pen2, D-Pen5] enkephalin and [D-Ala2, Glu4]deltorphin.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Reflex; Spinal Cord | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Purification and reconstitution of the delta opioid receptor.
Topics: Animals; Cattle; Cerebral Cortex; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme-Linked Immunosorbent Assay; Precipitin Tests; Receptors, Opioid, delta; Tumor Cells, Cultured | 1993 |
The E. coli envY gene encodes a high affinity opioid binding site.
Topics: Animals; Binding Sites; Cloning, Molecular; Dihydromorphine; DNA; DNA, Bacterial; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Escherichia coli; Gene Expression; Genes, Bacterial; L Cells; Mice; Mutation; Protein Biosynthesis; Receptors, Opioid; Transcription, Genetic; Transfection | 1993 |
Role of mu 1- and delta-opioid receptors in modulation of fetal EEG and respiratory activity.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetal Movement; Fetus; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep | 1993 |
Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Evidence for an involvement of the mu-type of opioid receptor in the modulation of learning.
Topics: Animals; Autoradiography; Blinking; Brain; Cerebral Ventricles; Conditioning, Classical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intraventricular; Learning; Male; Naloxone; Nictitating Membrane; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1993 |
Involvement of delta-opioid receptors in physical dependence on butorphanol.
Topics: Animals; Butorphanol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance-Related Disorders | 1993 |
Charge-remote fragmentation in a disulfide-containing peptide, [Pen]-enkephalin, under fast atom bombardment collisionally activated dissociation conditions.
Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indicators and Reagents; Oxidation-Reduction; Spectrometry, Mass, Fast Atom Bombardment | 1993 |
In vivo modulation of gastrointestinal motor activity by Met-enkephalin, morphine and enkephalin analogs in chickens.
Topics: Amino Acid Sequence; Animals; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Gastrointestinal Motility; Immunohistochemistry; Male; Molecular Sequence Data; Morphine; Motor Activity; Naloxone; Nerve Fibers; Vagotomy; Vagus Nerve | 1993 |
Inhibition of spinal opioid antinociception by intrathecal beta-endorphin1-27 in the rat.
Topics: Analgesics; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Injections, Spinal; Male; Morphine; Narcotic Antagonists; Narcotics; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time; Sheep; Spinal Cord | 1993 |
Solution conformations of the peptide backbone for DPDPE and its beta-MePhe4-substituted analogs.
Topics: Amino Acid Sequence; Analgesics; Dimethyl Sulfoxide; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptides, Cyclic; Protein Conformation; Solutions; Stereoisomerism; Thermodynamics | 1993 |
Antisense oligodeoxynucleotides to the kappa-1 receptor block the antinociceptive effects of delta 9-THC in the spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligonucleotides, Antisense; Pain; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, kappa; Spinal Cord | 1995 |
Cholecystokinin octapeptide reverses mu-opioid-receptor-mediated inhibition of calcium current in rat dorsal root ganglion neurons.
Topics: Animals; Calcium Channel Blockers; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Ganglia, Spinal; Ion Channel Gating; Male; Neurons; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1995 |
In vivo injection of antisense oligodeoxynucleotides to G alpha subunits and supraspinal analgesia evoked by mu and delta opioid agonists.
Topics: Analgesics, Opioid; Animals; Base Sequence; beta-Endorphin; Blotting, Western; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Mice; Molecular Sequence Data; Morphine; Oligonucleotides, Antisense; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
The effect of intrathecal opioid-receptor agonists on visceral noxious stimulation in rabbits.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Catheterization; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Spinal; Morphine; Motor Activity; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Viscera | 1996 |
Involvement of different subtypes of cholecystokinin receptors in opioid antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; beta-Endorphin; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Meglumine; Mice; Mice, Inbred ICR; Morphine; Narcotics; Pain Measurement; Proglumide; Pyrrolidines; Receptors, Cholecystokinin; Sincalide | 1995 |
Delta opioid receptors: reflexive, defensive and vocal affective responses in female rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Morphine; Motor Activity; Pain; Rats; Reaction Time; Receptors, Opioid, delta; Vocalization, Animal | 1995 |
Do SH-SY5Y human neuroblastoma cells express cannabinoid receptors?
Topics: Adenylyl Cyclase Inhibitors; Cannabinoids; Colforsin; Cyclic AMP; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Neuroblastoma; Potassium; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Tumor Cells, Cultured | 1995 |
Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Catheterization; Colon; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rectum | 1995 |
Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Peripheral Nerve Injuries; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1995 |
Conformational analysis of beta-methyl-para-nitrophenylalanine stereoisomers of cyclo[D-Pen2, D-Pen5]enkephalin by NMR spectroscopy and conformational energy calculations.
Topics: Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Conformation; Stereoisomerism; Thermodynamics | 1996 |
Development of a model for the delta-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Pen]OH with other conformationally constrained delta-receptor selective ligands.
Topics: Amino Acid Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Protein Conformation; Receptors, Opioid, delta | 1996 |
delta Opioid receptor in neuronal cells undergoes acute and homologous desensitization.
Topics: 1-Methyl-3-isobutylxanthine; Analgesics; Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Embryo, Mammalian; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Neurons; Rats; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 1996 |
Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated "knock-down" of opioid receptor in vivo.
Topics: Analgesics; Animals; Base Sequence; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligonucleotides, Antisense; Oligopeptides; Receptors, Opioid, delta | 1996 |
delta-Opioids stimulate inositol 1,4,5-trisphosphate formation, and so mobilize Ca2+ from intracellular stores, in undifferentiated NG108-15 cells.
Topics: Analgesics; Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Inositol 1,4,5-Trisphosphate; Neuroblastoma; Nickel; Nifedipine; Pertussis Toxin; Receptors, Opioid, delta; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Regulation of human B lymphocyte activation by opioid peptide hormones. Inhibition of IgG production by opioid receptor class (mu-, kappa-, and delta-) selective agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Analgesics; B-Lymphocytes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Humans; Immunoglobulin G; Interleukin-6; Lymphocyte Activation; Male; Opioid Peptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Staphylococcus aureus | 1996 |
Activation of delta-opioid receptors inhibits neuronal-like calcium channels and distal steps of Ca(2+)-dependent secretion in human small-cell lung carcinoma cells.
Topics: Analgesics; Base Sequence; Calcium; Calcium Channel Blockers; Calcium Channels; Carcinoma, Small Cell; Cyclic AMP; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Ion Channel Gating; Ionomycin; Ionophores; Lung Neoplasms; Membrane Potentials; Molecular Sequence Data; Opioid Peptides; Pertussis Toxin; Potassium Chloride; Receptors, Opioid, delta; Serotonin; Terpenes; Thapsigargin; Tritium; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1996 |
Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat.
Topics: Animals; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hot Temperature; Injections, Intraventricular; Male; Medulla Oblongata; Morphine; Nociceptors; Oligopeptides; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reticular Formation | 1995 |
Biochemical evidence of functional interaction between mu- and delta-opioid receptors in SK-N-BE neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Membrane Proteins; Neuroblastoma; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors; Tumor Cells, Cultured | 1996 |
Buprenorphine differentially alters opioid receptor adaptation in rat brain regions.
Topics: Adaptation, Physiological; Analgesics; Animals; Brain; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Oligopeptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1996 |
Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.
Topics: Analgesics; Animals; Blood-Brain Barrier; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Mice; Mice, Inbred Strains; Permeability; Prodrugs; Time Factors | 1996 |
Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology.
Topics: Amino Acid Sequence; Analgesics, Opioid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oligopeptides; Opioid Peptides; Phenylalanine; Protein Binding; Protein Conformation; Receptors, Opioid; Stereoisomerism; Tyrosine | 1996 |
The effects of delta-opioid receptor agonists on synaptic transmission in hamster submandibular ganglion.
Topics: Animals; Autonomic Fibers, Preganglionic; Cricetinae; Dimethylphenylpiperazinium Iodide; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; Ganglionic Stimulants; Naloxone; Narcotic Antagonists; Presynaptic Terminals; Receptors, Opioid, delta; Submandibular Gland; Synaptic Transmission | 1995 |
Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Cholecystokinin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Glioma; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Oligopeptides; Pain; Peptide Fragments; Receptors, Opioid, delta | 1996 |
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Cell Line; Chlorocebus aethiops; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Morphine; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella | 1996 |
The effects of dopamine D1 and D2 receptor antagonists on the rewarding effects of delta 1 and delta 2 opioid receptor agonists in mice.
Topics: Animals; Behavior, Animal; Benzazepines; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Oligopeptides; Receptors, Dopamine D1; Receptors, Opioid, delta; Self Administration; Sulpiride | 1996 |
L-Arginine reverses the abolition of hypovolaemic decompensation by N-nitro-L-arginine methyl ester and naloxone in conscious rabbits.
Topics: Animals; Arginine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Shock, Hemorrhagic | 1995 |
Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Oxidopamine; Peptide Fragments; Receptors, Opioid | 1995 |
Effects of central administration of highly selective opioid mu-, delta- and kappa-receptor agonists on plasma luteinizing hormone (LH), prolactin, and the estrogen-induced LH surge in ovariectomized ewes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Estradiol; Female; Injections, Intraventricular; Luteinizing Hormone; Narcotics; Oils; Ovariectomy; Prolactin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep | 1996 |
Passage of a delta-opioid receptor selective enkephalin, [D-penicillamine2,5] enkephalin, across the blood-brain and the blood-cerebrospinal fluid barriers.
Topics: Animals; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Models, Biological; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sucrose | 1996 |
Ocular action of an opioid peptide, DPDPE.
Topics: Administration, Topical; Analgesics; Animals; Ciliary Body; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Intraocular Pressure; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits | 1996 |
Autoradiographic comparison of [3H]DPDPE and [3H]DSLET binding: evidence for distinct delta 1 and delta 2 opioid receptor populations in rat brain.
Topics: Animals; Autoradiography; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1996 |
Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis).
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus | 1996 |
Effects of centrally administered opioid agonists on macrophage nitric oxide production and splenic lymphocyte proliferation.
Topics: Analgesics; Animals; Brain; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunoassay; Injections, Intraventricular; Macrophages; Male; Nitric Oxide; Rats; Rats, Inbred Lew; Receptors, Opioid; Spleen | 1996 |
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1996 |
Effect of antagonism of the NMDA receptor on tolerance to [D-Pen2,D-Pen5]enkephalin, a delta 1-opioid receptor agonist.
Topics: Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoquinolines; Male; Mice; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 1996 |
Variations of motor activity following intraventricular (D-Pen2, D-Pen5)-enkephalin administration: interaction with acute uncontrollable foot-shock in mice.
Topics: Analgesics; Animals; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exploratory Behavior; Injections, Intraventricular; Male; Mice; Motor Activity; Receptors, Opioid, delta; Stress, Psychological | 1996 |
Circannual variations in bear plasma albumin and its opioid-like effects on guinea pig ileum.
Topics: Analgesics; Animals; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hibernation; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Seasons; Serum Albumin; Ursidae | 1996 |
Development of a capillary zone electrophoresis assay to examine the disposition of [D-pen2,5]enkephalin in rats.
Topics: Acetonitriles; Analgesics; Animals; Buffers; Chemical Precipitation; Electrophoresis, Capillary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydrogen-Ion Concentration; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 1996 |
Alcohol drinking is reduced by a mu 1- but not by a delta-opioid receptor antagonist in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Effect of nitric oxide synthase inhibition on tolerance to the analgesic action of D-Pen2, D-Pen5 enkephalin and morphine in the mouse.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Nitric Oxide Synthase; Nitroarginine | 1996 |
Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 1996 |
Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aminobutyrates; Analgesics; Animals; Brain; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Thalamus | 1996 |
Functional analysis of opioid receptor subtypes in the ventromedial hypothalamic nucleus of the rat.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Ventromedial Hypothalamic Nucleus | 1996 |
Lipid membrane permeability of modified c[D-Pen2, D-Pen5]enkephalin peptides.
Topics: Calorimetry, Differential Scanning; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Lipid Bilayers; Liposomes; Membranes, Artificial; Peptides; Permeability; Structure-Activity Relationship | 1996 |
Alteration of calcitonin gene related peptide and its receptor binding sites during the development of tolerance to mu and delta opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Calcitonin Gene-Related Peptide; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunohistochemistry; Male; Morphine; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1995 |
Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens.
Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Membranes; Narcotics; Neostriatum; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Role of central mu, delta-1, and kappa-1 opioid receptors in opioid-induced muscle rigidity in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Muscle Rigidity; Narcotics; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
Portacaval anastomosis induces region-selective alterations of the endogenous opioid system in the rat brain.
Topics: Alcohol Drinking; Analysis of Variance; Animals; beta-Endorphin; Brain; Brain Chemistry; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naloxone; Narcotic Antagonists; Pituitary Gland; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and ex vivo binding and behavioral assays.
Topics: Animals; Behavior, Animal; Benzomorphans; Cinnamates; Cycloheximide; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine Derivatives; Narcotic Antagonists; Receptors, Opioid, mu | 1996 |
Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes.
Topics: Adenosine; Animals; Drug Synergism; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Synaptosomes | 1996 |
Novel scaffolds for non-peptide mimetics of delta opioid receptor agonists based on peptide leads.
Topics: Analgesics; Drug Design; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Models, Molecular; Receptors, Opioid, delta | 1996 |
Comparison of cyclic delta-opioid peptides with non-peptide delta-agonist spiroindanyloxymorphone (SIOM) using the message-address concept: a molecular modeling study.
Topics: Drug Design; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Naltrexone; Narcotic Antagonists; Oxymorphone; Peptides, Cyclic; Protein Binding; Protein Conformation; Receptors, Opioid, delta; Spiro Compounds; Structure-Activity Relationship | 1996 |
Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Nociceptin; Opioid Peptides; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene.
Topics: Allylamine; Analgesics, Opioid; Animals; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Isonipecotic Acids; Meperidine; Parasympatholytics; Phenols; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Induction of Fos-like immunoreactivity by opioids in guinea-pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Telencephalon | 1996 |
Met-enkephalin inhibits 5-hydroxytryptamine release from the rat ventral spinal cord via delta opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Serotonin; Spinal Cord | 1996 |
Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of trigeminothalamic neurons.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microelectrodes; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Trigeminal Nuclei | 1996 |
Effect of mu, delta and kappa opioid receptor agonists on a reactive oxygen species mediated model of skin inflammation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dermatitis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetic Resonance Spectroscopy; Male; Pyrrolidines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Opioid; Skin | 1996 |
Opioid receptor types for endogenous enkephalin in the thoracic ganglion of the crab, Carcinus maenas.
Topics: Analgesics, Opioid; Animals; Brachyura; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Ganglia; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Distribution and changes in mu- and kappa-opiate receptors during the midlife neurodevelopmental period of Coho salmon, Oncorhynchus kisutch.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Oncorhynchus kisutch; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thyroxine; Tritium | 1996 |
Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons.
Topics: Animals; Benzeneacetamides; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1996 |
Intrathecally injected nicotine enhances the antinociception induced by morphine but not beta-endorphin, D-Pen2,5-enkephalin and U50,488H administered intrathecally in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord | 1996 |
Cardiovascular effects of intrathecally injected mu, delta and kappa opioid receptor agonists in rabbits.
Topics: Animals; Baroreflex; Benzomorphans; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Naloxone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide).
Topics: Amino Acid Sequence; Binding, Competitive; Breast Neoplasms; Caseins; Cell Division; Cell Line; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Humans; Kinetics; Peptide Fragments; Receptors, Opioid, kappa | 1996 |
Role of kappa opioid receptors in modulating cholinergic twitches in the circular muscle of guinea-pig colon.
Topics: Acetylcholine; Animals; Colon; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Oligopeptides; Opioid Peptides; Receptors, Cholinergic; Receptors, Opioid, kappa | 1996 |
Nicotine enhances morphine- and beta-endorphin-induced antinociception at the supraspinal level in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nociceptors; Pain; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Opioids modulate the cholinergic contraction but not the nonadrenergic relaxation in guinea-pig airways in vitro.
Topics: Animals; Benzeneacetamides; Cholinergic Fibers; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea | 1996 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Haloperidol; Humans; Kinetics; Morphine; Naloxone; Neuroblastoma; Pentazocine; Phosphatidylinositols; Receptors, Opioid; Receptors, sigma; Trypsin; Tumor Cells, Cultured | 1996 |
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons; Nociceptors; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus | 1996 |
Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Brain Stem; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Solitary Nucleus; Stomach | 1996 |
Effects of morphine-3-glucuronide on the antinociceptive activity of peptide and nonpeptide opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Morphine Derivatives; Nociceptors; Oligopeptides; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Effects of competitive and noncompetitive antagonists of the N-methyl-D-aspartate receptor on the analgesic action of delta 1- and delta 2-opioid receptor agonists in mice.
Topics: Analgesics, Opioid; Animals; Antiparkinson Agents; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Isoquinolines; Male; Membranes; Mice; Oligopeptides; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 1996 |
Involvement of delta- and mu-opioid receptors in the potentiation of brain-stimulation reward.
Topics: Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Reward | 1996 |
Expression of mu-, delta- and kappa-opioid receptors in baculovirus-infected insect cells.
Topics: Adenylyl Cyclases; Animals; Baculoviridae; Benzeneacetamides; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Insecta; Kinetics; Protein Binding; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins | 1996 |
Electrical activity of the sensory afferent pathway in the enteric nervous system.
Topics: Afferent Pathways; Animals; Charybdotoxin; Cybernetics; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enteric Nervous System; Guinea Pigs; In Vitro Techniques; Mathematics; Models, Neurological; Neurons, Afferent; omega-Conotoxin GVIA; Peptides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Purinergic Agonists; Tetrodotoxin | 1996 |
Thermodynamics of ligand binding to the cloned delta-opioid receptor.
Topics: Animals; Benzamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Oligopeptides; Piperazines; Receptors, Opioid, delta; Recombinant Proteins; Thermodynamics | 1996 |
Delta-1 opioid receptor-mediated antinociceptive properties of a nonpeptidic delta opioid receptor agonist, (-)TAN-67, in the mouse spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Pyrrolidines; Quinolines; Reaction Time; Receptors, Opioid, delta; Spinal Cord | 1997 |
Involvement of dopamine-dependent and -independent mechanisms in the rewarding effects mediated by delta opioid receptor subtypes in mice.
Topics: Analgesics; Animals; Dopamine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Receptors, Opioid, delta; Reward | 1997 |
Pharmacological characterization of buprenorphine, a mixed agonist-antagonist with kappa 3 analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Buprenorphine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sensitivity and Specificity | 1997 |
Determination of delta-opioid in NG108-15 cells.
Topics: Animals; Benzylidene Compounds; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured | 1997 |
Effects of multiple intracerebroventricular injections of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin II on tolerance to their analgesic action and on brain delta-opioid receptors.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Cell Membrane; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Kinetics; Male; Mice; Oligopeptides; Receptors, Opioid, delta | 1997 |
Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Naltrexone; Narcotic Antagonists; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1997 |
Autoradiographic determination of changes in opioid receptor binding in the limbic system of the Columbian ground squirrel at different hibernation states.
Topics: Animals; Autoradiography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hibernation; Limbic System; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Sciuridae | 1997 |
Mu and delta opioid receptor activation inhibits omega-conotoxin-sensitive calcium channels in a voltage- and time-dependent mode in the human neuroblastoma cell line SH-SY5Y.
Topics: Barium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Neuroblastoma; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1997 |
Differential modulation by muscimol and baclofen on antinociception induced by morphine, beta-endorphin, D-Pen2,5-enkephalin and U50,488H administered intracerebroventricularly in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analysis of Variance; Animals; Baclofen; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Mice; Morphine; Muscimol; Pyrrolidines; Receptors, GABA; Receptors, Opioid, kappa | 1995 |
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.
Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared | 1997 |
14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists.
Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Cattle; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, mu; Tritium | 1997 |
The entry of [D-penicillamine2,5]enkephalin into the central nervous system: saturation kinetics and specificity.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Rats; Rats, Sprague-Dawley; Tritium | 1997 |
Delta and kappa opioid receptor subtypes and ingestion: antagonist and glucoprivic effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Ventricles; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperphagia; Infusions, Parenteral; Male; Naloxone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regression Analysis | 1997 |
Novel "restoration of function" mutagenesis strategy to identify amino acids of the delta-opioid receptor involved in ligand binding.
Topics: Amino Acid Sequence; Analgesics; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; Genetic Techniques; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Opioid, delta; Recombinant Fusion Proteins; Structure-Activity Relationship | 1997 |
Overexpression of delta-opioid receptors in recombinant baculovirus-infected Trichoplusia ni "High 5" insect cells.
Topics: Adenylyl Cyclases; Analgesics; Animals; Baculoviridae; Binding, Competitive; Blotting, Western; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunoblotting; Membrane Proteins; Mice; Naltrexone; Narcotic Antagonists; Ovary; Receptors, Opioid, delta; Recombinant Proteins; Spodoptera; Tritium; Viral Proteins | 1997 |
Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.
Topics: Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Structure-Activity Relationship; Vas Deferens | 1997 |
Analysis of the role of delta opioid receptors in gastroprotection in the rat.
Topics: Analgesics; Animals; Binding Sites; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; Gastric Mucosa; Ileum; Male; Mice; Mice, Inbred Strains; Morphine; Muscle, Smooth; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Stomach; Stomach Diseases; Vas Deferens | 1997 |
Extensive biliary excretion of the model opioid peptide [D-PEN2,5] enkephalin in rats.
Topics: Analgesics; Animals; Bile; Electrophoresis, Capillary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Liver; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1997 |
Opioid modulation of the fetal hypothalamic-pituitary-adrenal axis: the role of receptor subtypes and route of administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenocorticotropic Hormone; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hydrocortisone; Hypothalamo-Hypophyseal System; Injections, Intravenous; Injections, Intraventricular; Pituitary-Adrenal System; Pregnancy; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep | 1997 |
Putative kappa-2 opioid agonists are antihyperalgesic in a rat model of inflammation.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1997 |
Opioids binding mu and delta receptors exhibit diverse efficacy in the activation of Gi2 and G(x/z) transducer proteins in mouse periaqueductal gray matter.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunoelectrophoresis; Male; Mice; Molecular Sequence Data; Periaqueductal Gray; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Effects of ibogaine and noribogaine on the antinociceptive action of mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; Male; Mice; Morphine; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Effects of ibogaine on the development of tolerance to antinociceptive action of mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; Male; Mice; Morphine; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta-opioid receptors.
Topics: Analgesics; Animals; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glioma; Ketamine; Mice; N-Methylaspartate; Neuroblastoma; Neurons; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Signal Transduction | 1997 |
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Mice; Mice, Inbred C57BL; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neostigmine; Oligopeptides; Peptide Fragments | 1997 |
Opioid peptides: simultaneous delta agonism and mu antagonism in somatostatin analogues.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Molecular Structure; Opioid Peptides; Peptide Fragments; Peptides; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Vas Deferens | 1997 |
The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activation.
Topics: Amino Acid Sequence; Animals; Biological Transport; Cell Line; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Humans; Kidney; Mice; Receptors, Opioid, delta; Signal Transduction; Transfection | 1997 |
Antisense mapping DOR-1 in mice: further support for delta receptor subtypes.
Topics: Analgesia; Animals; Cloning, Molecular; DNA, Antisense; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exons; Male; Mice; Mice, Inbred Strains; Oligonucleotides, Antisense; Oligopeptides; Peptide Mapping; Receptors, Opioid, delta | 1997 |
Postnatal development of delta-opioid receptor subtypes in mice.
Topics: Animals; Animals, Suckling; Brain; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Oligopeptides; Receptors, Opioid, delta; Vas Deferens | 1997 |
Differential effects of mu-, delta- and kappa-opioid receptor agonists on the discriminative stimulus properties of cocaine in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Narcotics; Pyrrolidines; Quinolines; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders | 1997 |
Receptor-induced beta gamma release from fatty acylation-deficient mutants of G alpha z.
Topics: Acylation; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; COS Cells; Cyclic AMP; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Macromolecular Substances; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Neurons; Palmitic Acid; Point Mutation; Receptors, Opioid, delta; Recombinant Proteins; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1997 |
delta-opioid receptor mobilization of intracellular calcium in SH-SY5Y cells: lack of evidence for delta-receptor subtypes.
Topics: Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Oligopeptides; Receptors, Opioid, delta | 1997 |
The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia.
Topics: Analgesia; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Mice, Knockout; Mice, Transgenic; Receptors, Opioid, mu | 1997 |
Interactions between angiotensin II and delta opioid receptor subtype agonists upon water intake in rats.
Topics: Analgesics; Angiotensin II; Animals; Cerebral Ventricles; Drinking Behavior; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Receptors, Opioid, delta; Regression Analysis; Time Factors | 1997 |
Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Amino Acid Sequence; Analgesics; Cells, Cultured; Cyclic AMP; Dopamine Agonists; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Infant; Kidney; Molecular Sequence Data; Mutagenesis; Pertussis Toxin; Phosphorylation; Quinpirole; Receptors, Opioid, delta; Serine; Signal Transduction; Virulence Factors, Bordetella | 1997 |
7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.
Topics: Analgesia; Analgesics; Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Ligands; Male; Mice; Mice, Inbred ICR; Molecular Structure; Muscle, Smooth; Naltrexone; Oxymorphone; Receptors, Opioid, delta; Spiro Compounds; Vas Deferens | 1997 |
Voltage-dependent modulation of single N-Type Ca2+ channel kinetics by receptor agonists in IMR32 cells.
Topics: Barium; Calcium Channel Agonists; Calcium Channels; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Models, Chemical; Neuroblastoma; Norepinephrine; Patch-Clamp Techniques; Tumor Cells, Cultured | 1996 |
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.
Topics: Animals; Benzamides; CHO Cells; Cloning, Molecular; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naltrexone; Narcotic Antagonists; Piperazines; Quinolines; Receptors, Opioid, delta; Sulfur Radioisotopes | 1997 |
Intracisternal injection of opioids induces itch-associated response through mu-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cisterna Magna; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Pruritus; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Inhibition of airway constriction by opioids is different down the isolated bovine airway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Bronchi; Bronchoconstriction; Cattle; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Narcotics; Pyrrolidines; Receptors, Opioid; Trachea | 1997 |
Effects of some 7-arylidene and 7-heteroarylidene morphinan-6-ones on the antinociceptive activity of [D-Pen2, D-Pen5]enkephalin and [D-Ala2, Glu4]deltorphin II and on multiple opioid receptors.
Topics: Analgesics; Animals; Brain Chemistry; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Tissue Distribution; Vas Deferens | 1997 |
Pulsed magnetic field induced "analgesia" in the land snail, Cepaea nemoralis, and the effects of mu, delta, and kappa opioid receptor agonists/antagonists.
Topics: Analgesia; Animals; Electromagnetic Fields; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Snails | 1997 |
Gx/z is regulated by mu but not delta opioid receptors in the stimulation of the low Km GTPase activity in mouse periaqueductal grey matter.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Immunochemistry; Injections, Intraventricular; Kinetics; Male; Mice; Oligonucleotides; Oligopeptides; Periaqueductal Gray; Receptors, Opioid, delta; Receptors, Opioid, mu; Stimulation, Chemical | 1997 |
Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Vas Deferens | 1997 |
Role of amino- and carboxyl-terminal regions of G(alphaZ) in the recognition of Gi-coupled receptors.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Binding Sites; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Pertussis Toxin; Rats; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Opioid, delta; Receptors, Peptide; Structure-Activity Relationship; Virulence Factors, Bordetella | 1997 |
The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation.
Topics: Animals; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Mice; Pertussis Toxin; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.
Topics: Calcium; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; Glioma; Hybrid Cells; Kinetics; Neuroblastoma; Pertussis Toxin; Protein Kinase C; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Cardiovascular effects of microinjections of opioid agonists into the 'Depressor Region' of the ventrolateral periaqueductal gray region.
Topics: Analgesics; Animals; Benzeneacetamides; Blood Pressure; Bradycardia; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acids; Heart Rate; Homocysteine; Hypertension; Hypotension; Male; Microinjections; Neural Inhibition; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Animals; Binding Sites; Cell Membrane; CHO Cells; Cholera Toxin; Cloning, Molecular; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Magnesium; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Proteins; Sodium; Sulfur Radioisotopes; Virulence Factors, Bordetella | 1997 |
Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord | 1997 |
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 1997 |
Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors.
Topics: Aminobutyrates; Analgesics, Opioid; Animals; Binding, Competitive; Brain; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oligopeptides; Protein Binding; Protein Conformation; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Stereoisomerism | 1997 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Effect of 7-nitroindazole on tolerance to morphine, U-50,488H and [D-Pen2, D-Pen5] enkephalin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Indazoles; Male; Mice; Morphine; Nitric Oxide Synthase; Nociceptors; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1997 |
DAMGO and DPDPE facilitation of brain stimulation reward thresholds is blocked by the dopamine antagonist cis-flupenthixol.
Topics: Animals; Brain; Dopamine Antagonists; Drug Antagonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Flupenthixol; Injections; Male; Nucleus Accumbens; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Reward; Self Stimulation; Synaptic Transmission | 1997 |
Opiate agonists microinjected into the nucleus accumbens enhance sucrose drinking in rats.
Topics: Analgesics, Opioid; Animals; Drinking; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Feeding Behavior; Injections, Intraventricular; Male; Morphine; Motor Activity; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sucrose | 1997 |
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Topics: Animals; Binding, Competitive; Cell Membrane; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Isoquinolines; Kinetics; Male; Methylation; Mice; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1997 |
[D-Pen2,5]enkephalin and glutamate regulate the expression of delta-opioid receptors in rat cortical astrocytes.
Topics: Aniline Compounds; Animals; Animals, Newborn; Astrocytes; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fluorescent Dyes; Gene Expression Regulation; Glutamic Acid; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Xanthenes | 1997 |
Use of "natural" hibernation induction triggers for myocardial protection.
Topics: Analysis of Variance; Animals; Coronary Circulation; Disease Models, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Heart; Heart Arrest, Induced; Hibernation; Hypothermia, Induced; Male; Marmota; Myocardial Ischemia; Myocardial Stunning; Myocardium; Oxygen Consumption; Peptides; Premedication; Proteins; Rabbits; Receptors, Opioid, delta; Ursidae; Ventricular Function; Ventricular Function, Left; Ventricular Pressure | 1997 |
Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands.
Topics: Animals; Binding, Competitive; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mass Spectrometry; Mice; Muscle Contraction; Muscle, Smooth; Phenylalanine; Rats; Receptors, Opioid, delta; Vas Deferens | 1997 |
Sensitive analysis of [D-Pen2,5]enkephalin in rat serum by capillary electrophoresis and laser-induced fluorescence detection.
Topics: Animals; Electrophoresis, Capillary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fluorescent Dyes; Hydrogen-Ion Concentration; Lasers; Mass Spectrometry; Rats; Receptors, Opioid, delta; Rhodamines; Sensitivity and Specificity; Spectrometry, Fluorescence | 1997 |
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum.
Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Cholera Toxin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Narcotics; Pertussis Toxin; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Mu and delta opioids but not kappa opioid inhibit voltage-activated Ba2+ currents in neuronal F-11 cell.
Topics: Analgesics; Analgesics, Opioid; Animals; Barium; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylmaleimide; Gene Expression Regulation; Hybrid Cells; Ion Channel Gating; Mice; Neuroblastoma; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Sulfhydryl Reagents; Virulence Factors, Bordetella | 1997 |
Effects of NMDA receptor antagonists on delta1- and delta2-opioid receptor agonists-induced changes in the mouse brain [3H]DPDPE binding.
Topics: Animals; Brain; Dizocilpine Maleate; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Membranes; Mice; Oligopeptides; Protein Binding; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 1997 |
Blood-brain disposition and antinociceptive effects of -D-penicillamine2,5-enkephalin in the mouse.
Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice | 1997 |
Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Medulla Oblongata; Microinjections; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1997 |
The competitive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist LY293558 attenuates and reverses analgesic tolerance to morphine but not to delta or kappa opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoquinolines; Male; Mice; Morphine; Receptors, AMPA; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tetrazoles | 1997 |
Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects.
Topics: Animals; Benzylidene Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Sodium | 1997 |
Orphanin FQ has an inhibitory effect on the guinea pig ileum and the mouse vas deferens.
Topics: Animals; CHO Cells; Cricetinae; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle, Smooth; Nociceptin; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Vas Deferens | 1997 |
Stimulation of delta1- and delta2-opioid receptors produces amnesia in mice.
Topics: Amnesia; Analgesia; Animals; Avoidance Learning; Behavior, Animal; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Oligopeptides; Receptors, Opioid, delta | 1997 |
Delta-opiate DPDPE in magnetically oriented phospholipid micelles: binding and arrangement of aromatic pharmacophores.
Topics: Biophysical Phenomena; Biophysics; Carbon Isotopes; Dimyristoylphosphatidylcholine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydrogen; Lipid Bilayers; Magnetic Resonance Spectroscopy; Magnetics; Micelles; Models, Molecular; Phenylalanine; Phospholipid Ethers; Phospholipids; Protein Conformation; Receptors, Opioid, delta; Tyrosine | 1997 |
Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Formaldehyde; Male; Oligopeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1998 |
Binding of [3H][D-Ala2, MePhe4, Gly-ol5] enkephalin, [3H][D-Pen2, D-Pen5]enkephalin, and [3H]U-69,593 to airway and pulmonary tissues of normal and sensitized rats.
Topics: Animals; Asthma; Benzeneacetamides; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypersensitivity, Immediate; Lung; Male; Protein Binding; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory System | 1997 |
Up-regulation of brain N-methyl-D-aspartate receptors following multiple intracerebroventricular injections of [D-Pen2, D-Pen5] enkephalin and [D-Ala2, Glu4]deltorphin II in mice.
Topics: Animals; Brain; Dizocilpine Maleate; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Oligopeptides; Protein Binding; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Up-Regulation | 1997 |
Effect of chronic administration of morphine, U-50, 488H and [D-Pen2, D-Pen5]enkephalin on the concentration of cGMP in brain regions and spinal cord of the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Cyclic GMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Nitric Oxide; Nitric Oxide Synthase; Receptors, Opioid; Spinal Cord; Up-Regulation | 1997 |
Effect of chronic administration of [D-Pen2, D-Pen5] enkephalin on the activity of nitric oxide synthase in brain regions and spinal cord of mice.
Topics: Analgesics; Animals; Arginine; Brain; Citrulline; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Nitric Oxide Synthase; Pain Measurement; Receptors, Opioid, delta; Spinal Cord | 1998 |
[The use of central administration of the delta1- and delta2-opiate receptor agonists for prevention of the experimental adrenal arrhythmias].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Epinephrine; Injections, Intraventricular; Male; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Vagus Nerve | 1997 |
Electroconvulsive shock blocks the opioid-mediated inhibition of dopamine release in rat striatal slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Corpus Striatum; Dopamine; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Neural Inhibition; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; Chlorocebus aethiops; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epidermal Growth Factor; GTP-Binding Proteins; Kinetics; Macromolecular Substances; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pertussis Toxin; Pyrrolidines; ras Proteins; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1998 |
Lack of morphine and enkephalin tolerance in 129/SvEv mice: evidence for a NMDA receptor defect.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Arginine; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Mice, Inbred Strains; Morphine; Nitric Oxide; Nitroprusside; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1998 |
Actions of opioids on respiratory activity via activation of brainstem mu-, delta- and kappa-receptors; an in vitro study.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Medulla Oblongata; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiratory System | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Animals; Antibody Specificity; Astrocytes; Brain Chemistry; Calcium; Cell Cycle; Cell Division; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Flow Cytometry; Hippocampus; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Analgesic effects of a specific pulsed magnetic field in the land snail, Cepaea nemoralis: consequences of repeated exposures, relations to tolerance and cross-tolerance with DPDPE.
Topics: Analgesia; Analgesics; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Magnetics; Snails; Time Factors | 1998 |
Cardiovascular and metabolic responses to two receptor-selective opioid agonists in pregnant sheep.
Topics: Animals; Blood Glucose; Blood Pressure; Cardiovascular System; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Fetus; Heart Rate; Oligopeptides; Oxygen Consumption; Pregnancy; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep; Uterus | 1998 |
Interactions of cocaine with morphine, U-50,488H and [D-Pen2, D-Pen5]enkaphalin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Male; Mice; Morphine; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Is the reduced efficacy of morphine in diabetic rats caused by alterations of opiate receptors or of morphine pharmacokinetics?
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin | 1998 |
Suppression of phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity.
Topics: Adenylyl Cyclases; Analgesics; Bradykinin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Repression; Estrenes; GTP-Binding Proteins; Humans; Hybridomas; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Opioid, delta; Tumor Cells, Cultured; Type C Phospholipases | 1998 |
N-Methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C.
Topics: Animals; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Humans; Mice; Mutagenesis, Site-Directed; N-Methylaspartate; Neuroblastoma; Neurons; Phosphorylation; Protein Kinase C; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1998 |
Central effect of SNC 80, a selective and systemically active delta-opioid receptor agonist, on gastrointestinal propulsion in the mouse.
Topics: Animals; Benzamides; Central Nervous System; Colon; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Injections, Intraperitoneal; Male; Mice; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, sigma | 1998 |
Effects of kappa and delta opioid agonists on activity and thermosensitivity of rat hypothalamic neurons.
Topics: Animals; Dynorphins; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypothalamus; Hypothalamus, Anterior; In Vitro Techniques; Male; Neurons; Preoptic Area; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thermosensing | 1998 |
Regulation of the glial glutamate transporter GLT-1 by glutamate and delta-opioid receptor stimulation.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Expression Regulation; Glutamic Acid; Kinetics; Microscopy, Fluorescence; Neuroglia; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Synaptic Transmission | 1998 |
Structural features determining differential receptor regulation of neuronal Ca channels.
Topics: Analgesics; Barium; Benzeneacetamides; Calcium Channels; Cell Line; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Channel Gating; Mutagenesis; Naltrexone; Narcotic Antagonists; Neurons; Protein Structure, Tertiary; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Transfection | 1998 |
Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C.
Topics: Analgesics, Opioid; Animals; COS Cells; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Inositol Phosphates; Ligands; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases | 1998 |
delta Opioid receptor subtypes activate inositol-signaling pathways in the production of antinociception.
Topics: Analgesia; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Inositol; Male; Mice; Oligonucleotides, Antisense; Receptors, Opioid, delta; Type C Phospholipases | 1998 |
Opioids disrupt Ca2+ homeostasis and induce carbonyl oxyradical production in mouse astrocytes in vitro: transient increases and adaptation to sustained exposure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Astrocytes; Calcium; Drug Tolerance; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homeostasis; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Narcotics; Oxidative Stress; Reactive Oxygen Species; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Treatment of chronic allodynia in spinally injured rats: effects of intrathecal selective opioid receptor agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Chronic Disease; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypesthesia; Injections, Spinal; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord Injuries | 1998 |
The delta2-opioid receptor subtype stimulates phosphoinositide metabolism in mouse periaqueductal gray matter.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Inositol; Male; Mice; Oligopeptides; Periaqueductal Gray; Pertussis Toxin; Phosphatidylinositols; Receptors, Opioid, delta; Sensitivity and Specificity; Tritium; Virulence Factors, Bordetella | 1998 |
Chronic naltrexone differentially affects supraspinal delta-opioid receptor-mediated antinociception.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid, delta; Spinal Cord; Up-Regulation | 1998 |
Dissociation between the inhibitory and stimulatory effects of opioid peptides on cAMP formation in SK-N-SH neuroblastoma cells.
Topics: Calcium; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Kinetics; Neuroblastoma; Opioid Peptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1998 |
mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Transit; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Morphine; Receptors, Opioid, mu | 1998 |
Effects of C-terminal truncation of the recombinant delta-opioid receptor on phospholipase C and adenylyl cyclase coupling.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inositol 1,4,5-Trisphosphate; Mice; Mutation; Receptors, Opioid, delta; Recombinant Proteins; Sequence Deletion; Tumor Cells, Cultured; Type C Phospholipases | 1998 |
Contribution of phospholipase C-beta3 phosphorylation to the rapid attenuation of opioid-activated phosphoinositide response.
Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Estrenes; Humans; Narcotics; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Pyrrolidinones; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1998 |
Delta opioid receptor enhancement of mu opioid receptor-induced antinociception in spinal cord.
Topics: Analgesics; Animals; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 1998 |
The regulating manner of opioid receptors on distinct types of calcium channels in hamster submandibular ganglion cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium Channels; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Parasympathetic; Male; Naloxone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Submandibular Gland; Synaptic Transmission | 1998 |
Catecholaminergic CATH.a cells express predominantly delta-opioid receptors.
Topics: Adenylyl Cyclases; Animals; Catecholamines; Cell Line; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; In Vitro Techniques; Mice; Narcotic Antagonists; Neurons; Polymerase Chain Reaction; Radioligand Assay; Receptors, Opioid, delta; Receptors, sigma; Signal Transduction | 1998 |
Localized secretion of ATP and opioids revealed through single Ca2+ channel modulation in bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Antineoplastic Agents; Autocrine Communication; Barium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Cattle; Chromaffin Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exocytosis; Ion Channel Gating; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Opioid Peptides; Patch-Clamp Techniques; Peptides; Receptors, Opioid; Receptors, Purinergic; Spider Venoms; Suramin; Virulence Factors, Bordetella | 1998 |
Activation of opioid receptors inhibits neuronal-like calcium channels, distal steps of secretion, and cell proliferation in human small cell lung carcinoma cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Bucladesine; Calcium Channels; Carcinoma, Small Cell; Cell Division; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Lung Neoplasms; Naloxone; Neurons; Receptors, Opioid, delta; Serotonin; Thapsigargin; Time Factors; Tumor Cells, Cultured | 1998 |
Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints.
Topics: Algorithms; Amino Acid Sequence; Benzomorphans; Binding Sites; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Hydrogen Bonding; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; Morphinans; Peptides, Cyclic; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rhodopsin; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity | 1998 |
Delta-opioid receptors on astroglial cells in primary culture: mobilization of intracellular free calcium via a pertussis sensitive G protein.
Topics: Animals; Astrocytes; Calcium; Calcium Channels; Cells, Cultured; Cerebral Cortex; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Immunohistochemistry; Neuroglia; Neurons; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1998 |
Age- and temperature-dependent effects of opioids on medulla oblongata respiratory activity: an in vitro study in newborn rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Medulla Oblongata; Morphine; Rats; Rats, Sprague-Dawley; Respiration; Spinal Cord; Temperature | 1998 |
Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Nerve Fibers; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1998 |
Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain.
Topics: Analgesics, Opioid; Animals; Binding Sites; Brain; Brain Chemistry; Buprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ligands; Oligonucleotides, Antisense; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Involvement of nitric oxide in peripheral antinociception mediated by kappa- and delta-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzoates; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Formaldehyde; Imidazoles; Male; Nitric Oxide; Nitro Compounds; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1998 |
Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Naloxone; Receptors, Cell Surface; Receptors, Opioid; Transfection | 1998 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
The C-truncated delta-opioid receptor underwent agonist-dependent activation and desensitization.
Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Peptide Fragments; Phosphorylation; Polymerase Chain Reaction; Protein Kinase Inhibitors; Receptors, Opioid, delta; Staurosporine; Structure-Activity Relationship; Transfection | 1998 |
Role of central mu-opioid receptors in the modulation of nitric oxide production by splenocytes.
Topics: Analgesics; Analgesics, Opioid; Animals; Bacterial Toxins; Benzeneacetamides; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enterotoxins; Enzyme Inhibitors; Injections, Intraventricular; Lymphocytes; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Spleen; Superantigens | 1998 |
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection | 1998 |
Differences in delta opioid receptor antinociception, binding, and mRNA levels between BALB/c and CXBK mice.
Topics: Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Resistance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Nociceptors; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger; Tissue Distribution | 1998 |
Opioid inhibition of hippocampal interneurons via modulation of potassium and hyperpolarization-activated cation (Ih) currents.
Topics: Analgesics; Analgesics, Opioid; Animals; Baclofen; Barium; Cardiovascular Agents; Cations; Cell Size; Cells, Cultured; Cesium; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Interneurons; Male; Membrane Potentials; Potassium; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzofurans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oligopeptides; Pain Measurement; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Signal Transduction; Vas Deferens | 1998 |
Slide-binding characterization and autoradiographic localization of delta opioid receptors in rat and mouse brains with the tetrapeptide antagonist [3H]TIPP.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred BALB C; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tetrahydroisoquinolines | 1998 |
Altered disposition and antinociception of [D-penicillamine(2,5)] enkephalin in mdr1a-gene-deficient mice.
Topics: Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Knockout; Models, Biological; Tissue Distribution | 1998 |
Delta opioid receptor down-regulation is independent of functional G protein yet is dependent on agonist efficacy.
Topics: Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Rats; Receptors, Opioid; Tumor Cells, Cultured | 1998 |
Effects of mu and delta opioid agonists and antagonists on affective vocal and reflexive pain responses during social stress in rats.
Topics: Aggression; Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Narcotic Antagonists; Narcotics; Pain; Pain Threshold; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu; Reflex; Social Behavior; Stress, Psychological; Vocalization, Animal | 1998 |
Transport of opioid peptides into the central nervous system.
Topics: Animals; Blood-Brain Barrier; Cattle; Cells, Cultured; Central Nervous System; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; In Vitro Techniques; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Somatostatin | 1998 |
[Inhibitory effects of three opioid receptor agonists on synaptic transmission].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 1996 |
Receptor-activated Ca2+ increases in vibrodissociated cortical astrocytes: a nonenzymatic method for acute isolation of astrocytes.
Topics: Animals; Astrocytes; Calcium; Cell Separation; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glutamic Acid; Immunohistochemistry; Indans; Norepinephrine; Phenylephrine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Serotonin | 1998 |
Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons.
Topics: Analgesics; Analgesics, Opioid; Animals; Axotomy; Benzeneacetamides; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Causalgia; Dihydropyridines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Male; Morphine; Nerve Compression Syndromes; Neurons, Afferent; Nociceptin; omega-Conotoxin GVIA; Opioid Peptides; Peptides; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve; Sodium; Spinal Cord | 1998 |
Effects of DPDPE (a specific delta-opioid receptor agonist) and naloxone on hypothalamic monoamine concentrations during the pre-ovulatory LH surge in the rat.
Topics: Animals; Biogenic Monoamines; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Follicular Phase; Hypothalamus; Luteinizing Hormone; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1998 |
Vulnerability to stressor-induced disturbances in self-stimulation from the dorsal and ventral A10 area: differential effects of intraventricular D-Ala2-Met5-enkephalinamide, D-Ala2, N-Me-Phe4, Gly-Ol5-enkephalin, and D-Pen2, D-Pen5-enkephalin administrat
Topics: Animals; Electric Stimulation; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Foot; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu; Self Stimulation; Stress, Physiological; Tegmentum Mesencephali; Time Factors | 1998 |
Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence.
Topics: Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Dynamins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; Immunohistochemistry; Microscopy, Confocal; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Signal Transduction; Stimulation, Chemical | 1999 |
Opioid receptor subtype expression defines morphologically distinct classes of hippocampal interneurons.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Interneurons; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1999 |
5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by mu-opiate receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Models, Neurological; Neocortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptors, Opioid, mu; Receptors, Serotonin; Serotonin; Somatostatin; Synapses | 1998 |
Enkephalin receptors and receptor-mediated signal transduction in cultured human lymphocytes.
Topics: Calcium; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Lymphocytes; Naloxone; Receptors, Opioid; Signal Transduction | 1999 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Enkephalin analogs containing 4,4-difluoro-2-aminobutyric acid: synthesis and fluorine effect on the biological activity.
Topics: Aminobutyrates; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fluorine; Guinea Pigs; Ileum; Male; Mice; Models, Chemical; Receptors, Opioid, delta; Vas Deferens | 1998 |
Kappa1-opioid binding sites are the dominant opioid binding sites in surgical specimens of human pheochromocytomas and in a human pheochromocytoma (KAT45) cell line.
Topics: Analgesics, Opioid; Binding Sites; Binding, Competitive; Catecholamines; Cell Membrane; Diprenorphine; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epinephrine; Ethylketocyclazocine; Humans; Narcotic Antagonists; Norepinephrine; Opioid Peptides; Pheochromocytoma; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium; Tumor Cells, Cultured | 1999 |
The role of aminopeptidase N in Met-enkephalin modulated superoxide anion release.
Topics: Adult; Analgesics; Analgesics, Opioid; CD13 Antigens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Leucine; Male; Neutrophils; Oligopeptides; Protease Inhibitors; Superoxides | 1999 |
Modulation of cocaine-induced antinociception by opioid-receptor agonists.
Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa | 1999 |
Mu- and delta-opioid receptor densities in respiratory-related brainstem regions of neonatal swine.
Topics: Analgesics; Analgesics, Opioid; Animals; Animals, Newborn; Binding Sites; Brain Stem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Physiological Phenomena; Swine; Swine, Miniature | 1999 |
Age- and sex-related differences in opioid receptor densities in the songbird vocal control system.
Topics: Aging; Analgesics, Opioid; Animals; Autoradiography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Image Processing, Computer-Assisted; Male; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reproduction; Sex Characteristics; Songbirds; Vocalization, Animal | 1999 |
Cyclic AMP analogs induce synthesis, processing, and secretion of prepro nociceptin/orphanin FQ-derived peptides by NS20Y neuroblastoma cells.
Topics: Animals; Cell Size; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Narcotics; Neurites; Neuroblastoma; Neurons; Nociceptin; Opioid Peptides; Peptide Fragments; Radioimmunoassay; Receptors, Opioid, delta; RNA, Messenger; Signal Transduction; Thionucleotides; Time Factors; Tumor Cells, Cultured | 1999 |
Delta-opioid receptor immunoreactivity on astrocytes is upregulated during mitosis.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mitosis; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spectrometry, Fluorescence; Up-Regulation | 1999 |
Stimulation of phospholipase C by the cloned mu, delta and kappa opioid receptors via chimeric G alpha(q) mutants.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cloning, Molecular; COS Cells; DNA, Complementary; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Type C Phospholipases | 1999 |
Characterization of mechanical withdrawal responses and effects of mu-, delta- and kappa-opioid agonists in normal and mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Physical Stimulation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Substance Withdrawal Syndrome | 1999 |
Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoantibodies; Biological Transport; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epitopes; GTP-Binding Protein alpha Subunits, Gi-Go; Immunoblotting; Immunoglobulin G; Injections, Intraventricular; Iodine Radioisotopes; Male; Mice; Mice, Inbred Strains; Microscopy, Immunoelectron; Morphine; Neurons; Nociceptors; Oligopeptides; Pain; Protein Kinase C; Signal Transduction | 1999 |
Binding properties of C-truncated delta opioid receptors.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Peptide Fragments; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Functional blockade of opioid analgesia by orphanin FQ/nociceptin.
Topics: Analgesia; Analgesics, Opioid; Animals; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Narcotic Antagonists; Nerve Tissue Proteins; Nociceptin; Nociceptin Receptor; Oligonucleotides, Antisense; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa | 1998 |
Effect of salmon-calcitonin on the analgesic effect of selective mu, delta and kappa opioid agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membranes; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Morphine; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Tritium | 1999 |
Site-specific effects of the nonsteroidal anti-inflammatory drug lysine clonixinate on rat brain opioid receptors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Clonixin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Lysine; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Tritium | 1999 |
Effect of phosducin on opioid receptor function.
Topics: Cyclic AMP; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Eye Proteins; Flow Cytometry; Glioma; Green Fluorescent Proteins; GTP Phosphohydrolases; GTP-Binding Protein Regulators; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Luminescent Proteins; Microscopy, Confocal; Nerve Tissue Proteins; Neuroblastoma; Phosphoproteins; Radioligand Assay; Receptors, Opioid; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured | 1999 |
The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation.
Topics: Adenylyl Cyclase Inhibitors; Arrestins; beta-Adrenergic Receptor Kinases; beta-Arrestin 2; beta-Arrestins; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Phosphorylation; Receptors, Opioid, mu; Time Factors; Transfection | 1999 |
Respiratory depression after intravenous administration of delta-selective opioid peptide analogs.
Topics: Analgesics; Animals; Benzamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Piperazines; Pregnancy; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Physiological Phenomena; Sheep | 1999 |
Enhanced antinociception of the model opioid peptide [D-penicillamine] enkephalin by P-glycoprotein modulation.
Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Drug Administration Routes; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoquinolines; Mice; Opioid Peptides; Pain Measurement; Tetrahydroisoquinolines; Tissue Distribution; Verapamil | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
Transport of the delta-opioid receptor agonist [D-penicillamine2,5] enkephalin across the blood-brain barrier involves transcytosis1.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Endocytosis; Endothelium, Vascular; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; In Vitro Techniques; Kinetics; Permeability; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1999 |
Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Brain; Cardiovascular Agents; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Membranes; Middle Aged; Myocardium; Nociceptin; Oligopeptides; Opioid Peptides; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes | 1999 |
Augmenting effect of opioids on nitrite production by stimulated murine macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitrites; Opioid Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection | 1998 |
Antianalgesic action of dynorphin A mediated by spinal cholecystokinin.
Topics: Analgesia; Analgesics; Animals; Antibodies; Cholecystokinin; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Injections, Spinal; Male; Meglumine; Mice; Morphine; Proglumide; Receptors, Cholecystokinin; Receptors, Opioid, delta; Spinal Cord | 1999 |
Electrophysiological studies on the postnatal development of the spinal antinociceptive effects of the delta opioid receptor agonist DPDPE in the rat.
Topics: Afferent Pathways; Age Factors; Analgesics; Animals; Electric Stimulation; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nerve Fibers; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1999 |
Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity.
Topics: Actins; Animals; Blood-Brain Barrier; Calcium Channel Blockers; Capillary Permeability; Cattle; Cell Hypoxia; Cerebral Cortex; Coculture Techniques; Culture Media, Conditioned; Endothelium, Vascular; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucose; Imidazoles; Insulin; Nifedipine; Receptors, Opioid, delta; Sucrose | 1999 |
Interaction between medullary and spinal delta1 and delta2 opioid receptors in the production of antinociception in the rat.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Medulla Oblongata; Microinjections; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1999 |
Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Solitary Nucleus; Stomach; Vagus Nerve | 1999 |
Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.
Topics: Animals; Biological Assay; Chemistry, Pharmaceutical; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Peptide Biosynthesis; Protein Binding; Protein Precursors; Receptors, Opioid, delta; Vas Deferens | 1999 |
Kinetic study of N-type calcium current modulation by delta-opioid receptor activation in the mammalian cell line NG108-15.
Topics: Animals; Biophysical Phenomena; Biophysics; Calcium Channel Blockers; Calcium Channels; Cell Line; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Membrane Potentials; Models, Biological; Nifedipine; omega-Conotoxin GVIA; Peptides; Receptors, Opioid, delta | 1999 |
Mu-opioid receptor modulation of calcium channel current in periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1.
Topics: Animals; Baclofen; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Periaqueductal Gray; Receptors, Opioid, mu | 1999 |
Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1999 |
Opioid peptides inhibit the action of oestradiol on human myometrial cells in culture.
Topics: Adult; Cell Division; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Estradiol; Female; Humans; Inhibitory Concentration 50; Muscle, Smooth; Myometrium; Naloxone; Narcotic Antagonists; Progesterone | 1999 |
Differential desensitization of human delta-opioid receptors by peptide and alkaloid agonists.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Analgesics; Analgesics, Opioid; Cyclic AMP; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Humans; Naloxone; Neuroblastoma; Oligopeptides; Peptides; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Presynaptic mu and delta opioid receptor modulation of GABAA IPSCs in the rat globus pallidus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analgesics, Opioid; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Excitatory Amino Acid Antagonists; GABA Antagonists; Globus Pallidus; In Vitro Techniques; Male; Membrane Potentials; Neostriatum; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Synaptic Transmission; Tetrodotoxin | 1999 |
Effect of chronic social stress on delta-opioid receptor function in the rat.
Topics: Adrenal Glands; Agonistic Behavior; Analgesia; Animals; Benzamides; Body Temperature; Body Weight; Brain; Catecholamines; Chronic Disease; Corticosterone; Defecation; Dominance-Subordination; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Motor Activity; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Social Environment; Stress, Psychological | 1999 |
Antibodies and antisense oligodeoxynucleotides to mu-opioid receptors, selectively block the effects of mu-opioid agonists on intestinal transit and permeability in mice.
Topics: Animals; Antibodies, Blocking; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Gastrointestinal Transit; Injections, Intraventricular; Intestinal Absorption; Male; Mice; Morphine; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Receptors, Opioid, mu | 1999 |
Comparison of cardiovascular responses to intra-hippocampal mu, delta and kappa opioid agonists in spontaneously hypertensive rats and isolation-induced hypertensive rats.
Topics: Analgesics; Animals; Cardiovascular System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hippocampus; Hypertension; Male; Opioid Peptides; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Opioid receptor upregulation in mu-opioid receptor deficient CXBK and outbred Swiss Webster mice.
Topics: Analgesics; Animals; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Expression; Male; Mice; Mice, Mutant Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Up-Regulation | 1999 |
Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord.
Topics: Animals; Benzeneacetamides; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Opioid Peptides; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Synaptic Transmission | 1999 |
Epidural opioid analgesia in infant rats I: mechanical and heat responses.
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Stress, Mechanical | 1999 |
Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin.
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Capsaicin; Carrageenan; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Subcutaneous; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Attenuation of delta opioid receptor-mediated signaling by kainic acid in neural cells: involvement of protein kinase C and intracellular Ca2+.
Topics: Animals; Calcium; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Kainic Acid; Mice; Neurons; Nociceptin Receptor; Protein Kinase C; Receptors, AMPA; Receptors, Opioid; Receptors, Opioid, delta; Signal Transduction; Tumor Cells, Cultured | 1999 |
Differential G-protein activation by alkaloid and peptide opioid agonists in the human neuroblastoma cell line SK-N-BE.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Animals; Azides; Cell Membrane; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Isoelectric Point; Neuroblastoma; Neurons; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Peptides; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
Agonist-dependent desensitization of the kappa opioid receptor by G protein receptor kinase and beta-arrestin.
Topics: Amino Acid Sequence; Animals; Arrestins; Benzeneacetamides; beta-Arrestin 2; beta-Arrestins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; G-Protein-Coupled Receptor Kinase 3; Molecular Sequence Data; Protein Serine-Threonine Kinases; Pyrrolidines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Opioid, kappa; Structure-Activity Relationship | 1999 |
Monoclonal antibody to the delta opioid receptor acts as an agonist in dual regulation of adenylate cyclase in NG108-15 cells.
Topics: Adenylyl Cyclases; Alprostadil; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epitopes; Fluorescent Antibody Technique; Glioma; Molecular Sequence Data; Neuroblastoma; Precipitin Tests; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Presynaptic kappa-opioid and muscarinic receptors inhibit the calcium-dependent component of evoked glutamate release from striatal synaptosomes.
Topics: 4-Aminopyridine; Animals; Calcium; Chelating Agents; Dicarboxylic Acids; Egtazic Acid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Neostriatum; Nerve Endings; Neurotransmitter Uptake Inhibitors; Potassium Channel Blockers; Potassium Channels; Pyrrolidines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Opioid, kappa; Receptors, Presynaptic; Synaptosomes | 1999 |
Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the delta-opioid receptor.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Substitution; Animals; Aspartic Acid; Binding, Competitive; Chlorocebus aethiops; Codon; Colforsin; COS Cells; Cyclic AMP; Diprenorphine; DNA, Complementary; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ligands; Mice; Mutagenesis, Site-Directed; Naloxone; Pertussis Toxin; Point Mutation; Protein Binding; Receptors, Opioid, delta; Recombinant Fusion Proteins; Second Messenger Systems; Transfection; Virulence Factors, Bordetella | 1999 |
delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Evoked Potentials; Female; Ganglia, Spinal; Male; Neurons; Nimodipine; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1999 |
Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Glioma; Hybrid Cells; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Neuroblastoma; Nociceptin Receptor; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Kinase C; Pyridines; Receptors, Opioid; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1999 |
(2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor.
Topics: Animals; CHO Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Membranes; Protein Binding; Receptors, Opioid, delta; Sulfur Radioisotopes; Tetrahydroisoquinolines; Tyrosine | 1999 |
Peptide transport system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Capillaries; Carrier Proteins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Iodine Radioisotopes; Male; Mice; Mice, Inbred ICR; MSH Release-Inhibiting Hormone; Receptors, Opioid; Thyrotropin-Releasing Hormone; Tyrosine | 1999 |
Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Calcium Channel Blockers; Calcium Channels, N-Type; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Humans; Neuroblastoma; omega-Conotoxins; Pertussis Toxin; Potassium Cyanide; Receptors, Opioid, kappa; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
The effect of halogenation on blood-brain barrier permeability of a novel peptide drug.
Topics: Animals; Blood-Brain Barrier; Cattle; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Halogens; Mice; Octanols; Peptides; Permeability; Sodium Chloride | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
Topics: Analgesics, Opioid; Animals; Benzamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membranes; Mice; Mice, Knockout; Oligopeptides; Pain Measurement; Piperazines; Protein Binding; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 2000 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dopamine; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exploratory Behavior; Foot; Habituation, Psychophysiologic; Hot Temperature; Mice; Mice, Knockout; Models, Neurological; Morphine; Motor Activity; Nociceptors; Oligopeptides; Pain; Pain Threshold; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Stress, Physiological; Swimming; Tail; Viscera | 2000 |
Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.
Topics: Analgesics, Opioid; Animals; Antimetabolites; Apoptosis; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Mice; Microscopy, Electron; Morphine; Naloxone; Narcotic Antagonists; Neurites; Neurons; Oligopeptides; Opioid-Related Disorders; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Stem Cells | 2000 |
mu-Opioid receptor inhibits N-type Ca2+ channels in the calyx presynaptic terminal of the embryonic chick ciliary ganglion.
Topics: Analgesics, Opioid; Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Chick Embryo; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Excitatory Postsynaptic Potentials; Ganglia, Parasympathetic; Naloxone; Narcotic Antagonists; Neural Inhibition; omega-Conotoxin GVIA; Patch-Clamp Techniques; Presynaptic Terminals; Receptors, Opioid, mu; Synaptic Transmission | 2000 |
Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
Topics: Age Factors; Amnesia; Analgesics, Opioid; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Chickens; Chloramphenicol; Conditioning, Psychological; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Female; Male; Memory; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Protein Synthesis Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 2000 |
Cornea-responsive medullary dorsal horn neurons: modulation by local opioids and projections to thalamus and brain stem.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Blinking; Carbon Dioxide; Cornea; Efferent Pathways; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Facial Nerve; Male; Medulla Oblongata; Microinjections; Morphine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Stimulation, Chemical; Thalamus; Trigeminal Caudal Nucleus | 2000 |
Antianalgesic action of nociceptin originating in the brain is mediated by spinal prostaglandin E(2) in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Indomethacin; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Nociceptin; Opioid Peptides; Pain Measurement; Receptors, Prostaglandin; Spinal Cord; Substance P | 2001 |
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans.
Topics: Acids; Analgesics; Analgesics, Opioid; Animals; Cell Differentiation; CHO Cells; Cricetinae; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Fentanyl; Humans; Naloxone; Narcotic Antagonists; Neuroblastoma; Neurons; Tumor Cells, Cultured | 2001 |
Supraspinal delta- and mu-opioid receptors mediate gastric mucosal protection in the rat.
Topics: Animals; beta-Endorphin; Brain; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Hydrochloric Acid; Male; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Stomach Ulcer; Vagotomy | 2001 |
Interaction of enkephalin peptides with anionic model membranes.
Topics: Analgesics; Anions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Lipid Bilayers; Membranes, Artificial; Molecular Structure; Peptides, Cyclic; Permeability; Phospholipids; Protein Conformation; Static Electricity; Surface Properties | 2002 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
Pluronic p85 block copolymer enhances opioid peptide analgesia.
Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Capillaries; Drug Synergism; Endothelium, Vascular; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Poloxalene; Reaction Time; Solvents | 2002 |
[The postburn change in hypothalamic paraventricular beta-endorphin and the roles of delta-receptor in scalded rats].
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Blood Pressure; Burns; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Heart Rate; Male; Narcotic Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Survival Analysis | 2002 |
Effect of in vivo and in vitro stimulation of delta1-opioid receptors on myocardial resistance to arrhythmogenic action of ischemia and reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta | 2002 |
Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog.
Topics: Alanine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord; Sulfides | 2003 |
Effect of peptide conformation on membrane permeability.
Topics: Calorimetry, Differential Scanning; Cell Membrane Permeability; Cholesterol; Dialysis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Lipid Bilayers; Liposomes; Molecular Conformation; Peptides; Phosphatidylcholines; Thermodynamics; Titrimetry | 2003 |
The regulation of steroidogenesis by opioid peptides in porcine theca cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; Cells, Cultured; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Estradiol; Female; Opioid Peptides; Progesterone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Steroids; Swine; Testosterone; Theca Cells | 2003 |
Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Decanoic Acids; Disease Models, Animal; Drug Antagonism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Hydroxy Acids; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Naloxone; Potassium Channels; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, delta; Sclerosis; Ventricular Fibrillation | 2003 |
The influence of opioid peptides on steroidogenesis in porcine granulosa cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Granulosa Cells; Luteinizing Hormone; Opioid Peptides; Ovarian Follicle; Swine | 2004 |
Enkephalinergic inhibition of raphe pallidus inputs to rat hypoglossal motoneurones in vitro.
Topics: Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Postsynaptic Potentials; Glutamic Acid; Hypoglossal Nerve; Male; Motor Neurons; Presynaptic Terminals; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Opioid, mu; Synaptic Transmission; Tongue | 2004 |
Delta-opioid receptor antagonists exhibit properties of partial delta-receptor agonists in isolated perfused heart.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Naltrexone; Oligopeptides; Perfusion; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta | 2004 |
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin | 2005 |
Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats.
Topics: Adamantane; Animals; Antidepressive Agents; Autoradiography; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Expression Regulation; Immobility Response, Tonic; In Situ Hybridization; Male; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Swimming; Tetrahydroisoquinolines | 2006 |
Delta and mu opioid receptors from the brain of a urodele amphibian, the rough-skinned newt Taricha granulosa: cloning, heterologous expression, and pharmacological characterization.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Endorphin; Brain Chemistry; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Molecular Sequence Data; Naloxone; Phylogeny; Receptors, Opioid, delta; Receptors, Opioid, mu; Salamandridae; Sequence Alignment | 2006 |
Presynaptic delta opioid receptors regulate ethanol actions in central amygdala.
Topics: Amygdala; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ethanol; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Receptors, Opioid, delta | 2007 |
Bioactive conformations of two seminal delta opioid receptor penta-peptides inferred from free-energy profiles.
Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Rubiaceae | 2014 |
In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Brain Edema; Brain Infarction; Brain Ischemia; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Ischemia; Motor Activity; Neurons; Neuroprotective Agents; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reperfusion Injury; Severity of Illness Index; Stroke | 2015 |
Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers.
Topics: Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fluorescein; Fluorescence; Fluorescent Dyes; Humans; Maleimides; Models, Molecular | 2017 |
Amniotic-fluid ingestion enhances central δ-opioid-induced hypoalgesia in rats in the cold-water tail-flick assay in a repeated-measures design.
Topics: Amniotic Fluid; Analgesics; Analgesics, Opioid; Animals; Cold Temperature; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Pain; Pain Measurement; Pain Threshold; Pregnancy; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Water | 2018 |