Compounds > enkephalin, d-penicillamine (2,5)-
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enkephalin, d-penicillamine (2,5)- and 7-benzylidenenaltrexone

enkephalin, d-penicillamine (2,5)- has been researched along with 7-benzylidenenaltrexone in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (60.71)18.2507
2000's9 (32.14)29.6817
2010's2 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bezawada, P; Coop, A; Cunningham, CW; Devereaux, AL; Griggs, NW; Healy, JR; Matsumoto, RR; Traynor, JR1
Hammond, DL; Littell, L; Stewart, PE1
Armstead, WM1
Kamei, J; Misawa, M; Mizoguchi, H; Nagase, H; Suzuki, T; Yoshiike, M1
Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H1
D'Alecy, LG; Mayfield, KP1
Búzás, B; Cox, BM; Izenwasser, S; Portoghese, PS1
Bowen, WD; Carlisi, VJ; Hruby, VJ; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Wild, KD1
Portoghese, PS; Sofuoglu, M; Takemori, AE1
Mokha, SS; Wang, XM; Yan, JQ; Zhang, KM1
Fujimoto, J; Ho, BY; Holmes, BB; Zhao, J1
Nelson, WL; Palmer, RB; Upthagrove, AL1
Khan, S; Smith, ME1
Hammond, DL; Thorat, SN1
Szekeres, PG; Traynor, JR1
Fujimoto, JM; Gorny, JM; Rady, JJ1
Mika, J; Przewłocka, B; Przewłocki, R1
Badhwar, V; Bolling, SF; Kilgore, K; Oeltgen, PR; Schwartz, CF; Su, TP1
Broom, DC; Nitsche, JF; Pintar, JE; Rice, KC; Traynor, JR; Woods, JH1
Caffrey, JL; Farias, M; Jackson, KE; Yoshishige, D1
Lunzer, MM; Portoghese, PS2
Brown, DR; Townsend, DW1
Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K1
Sadee, W; Sun, X; Wang, D1
Harvey, JH; van Rijn, RM; Whistler, JL1
Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A1

Other Studies

28 other study(ies) available for enkephalin, d-penicillamine (2,5)- and 7-benzylidenenaltrexone

ArticleYear
Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands.
    Bioorganic & medicinal chemistry letters, 2017, 02-01, Volume: 27, Issue:3

    Topics: Analgesics; Animals; Benzylidene Compounds; Ligands; Mice; Oxymorphone; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu

2017
Antinociception and delta-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:3

    Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord

1995
The contribution of delta 1- and delta 2-opioid receptors to hypoxia-induced pial artery dilation in the newborn pig.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1995, Volume: 15, Issue:3

    Topics: Animals; Animals, Newborn; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypoxia; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pia Mater; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Vasodilation

1995
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice.
    Japanese journal of pharmacology, 1994, Volume: 66, Issue:1

    Topics: Analgesics; Animals; Benzylidene Compounds; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu

1994
Streptozotocin-induced diabetes selectively enhances antinociception mediated by delta 1- but not delta 2-opioid receptors.
    Life sciences, 1994, Volume: 55, Issue:6

    Topics: Analgesia; Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin

1994
Delta-1 opioid agonist acutely increases hypoxic tolerance.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Benzylidene Compounds; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypoxia; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid, delta

1994
Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain.
    Life sciences, 1994, Volume: 54, Issue:7

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Benzylidene Compounds; Caudate Nucleus; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta

1994
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Animals; Benzylidene Compounds; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Thiocyanates; Vas Deferens

1993
7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord.
    Life sciences, 1993, Volume: 52, Issue:8

    Topics: Analgesics; Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Spinal Cord

1993
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat.
    Brain research, 1996, Nov-11, Volume: 739, Issue:1-2

    Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons; Nociceptors; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus

1996
Determination of delta-opioid in NG108-15 cells.
    European journal of pharmacology, 1997, Jan-14, Volume: 319, Issue:1

    Topics: Animals; Benzylidene Compounds; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured

1997
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.
    Journal of medicinal chemistry, 1997, Feb-28, Volume: 40, Issue:5

    Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared

1997
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle.
    Peptides, 1997, Volume: 18, Issue:1

    Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Mice; Mice, Inbred C57BL; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neostigmine; Oligopeptides; Peptide Fragments

1997
Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Medulla Oblongata; Microinjections; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta

1997
Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3

    Topics: Animals; Benzylidene Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Sodium

1997
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:4

    Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors

1998
The role of delta-opioid receptor subtypes in neuropathic pain.
    European journal of pharmacology, 2001, Mar-09, Volume: 415, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzylidene Compounds; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Protein Isoforms; Rats; Rats, Wistar; Receptors, Opioid, delta; Sciatic Nerve; Time Factors

2001
Opioids confer myocardial tolerance to ischemia: interaction of delta opioid agonists and antagonists.
    The Journal of thoracic and cardiovascular surgery, 2001, Volume: 122, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cardiac Surgical Procedures; Coronary Circulation; Disease Models, Animal; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Heart Arrest, Induced; Hypothermia, Induced; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Organ Size; Oxygen Consumption; Rabbits; Receptors, Opioid, delta; Recovery of Function; Stroke Volume; Ventricular Pressure

2001
Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzylidene Compounds; Convulsants; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta

2002
Cardiac enkephalins interrupt vagal bradycardia via delta 2-opioid receptors in sinoatrial node.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:5

    Topics: Analgesics; Analgesics, Opioid; Animals; Benzylidene Compounds; Bradycardia; Dogs; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Quinolines; Receptors, Opioid, delta; Sinoatrial Node; Vagus Nerve

2003
Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord.
    European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3

    Topics: Animals; Benzylidene Compounds; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Immune Sera; Mice; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord

2003
Pharmacological characterization of a 7-benzylidenenaltrexone-preferring opioid receptor in porcine ileal submucosa.
    British journal of pharmacology, 2003, Volume: 140, Issue:4

    Topics: Amphibian Proteins; Animals; Anions; Benzamides; Benzylidene Compounds; Biological Transport, Active; Carrier Proteins; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Gastrointestinal Motility; Ileum; Intestinal Mucosa; Male; Naltrexone; Neurons, Afferent; Oligopeptides; Piperazines; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Tritium

2003
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.
    Neuroscience, 2005, Volume: 135, Issue:1

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin

2005
Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:2

    Topics: Benzylidene Compounds; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction

2007
Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraventricular; Injections, Spinal; Ligands; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa

2007
A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers.
    Methods in molecular biology (Clifton, N.J.), 2013, Volume: 995

    Topics: Benzylidene Compounds; Calcium Signaling; Cell Culture Techniques; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; HEK293 Cells; High-Throughput Screening Assays; Humans; Naltrexone; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Recombinant Proteins; Spectrometry, Fluorescence; Transfection

2013
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
    Molecular pharmacology, 1994, Volume: 45, Issue:2

    Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software

1994
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
    NIDA research monograph, 1998, Volume: 178

    Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders

1998