Compounds > enkephalin--ala(2)-mephe(4)-gly(5)-

enkephalin--ala(2)-mephe(4)-gly(5)- and tiotidine

enkephalin--ala(2)-mephe(4)-gly(5)- has been researched along with tiotidine* in 1 studies

Other Studies

1 other study(ies) available for enkephalin--ala(2)-mephe(4)-gly(5)- and tiotidine

Article	Year
Substituted pyrido[3,2-b]oxazin-3(4H)-ones: synthesis and evaluation of antinociceptive activity. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:2 A new series of N-substituted pyrido[3,2-b]oxazinones has been synthesized, pharmacologically evaluated, and compared with acetyl salicylic acid. The compound with the maximal combination of safety and analgesic efficacy was 4-¿3-[4-(4-fluorophenyl-1-piperazinyl)propyl]¿-2H-pyrido[3,2-b]-1, 4-oxazin-3(4H)-one (6c) with ED50 values of 12.5 mg/kg po (mouse: phenylquinone writhing test) and 27.8 mg/kg po (rat: acetic acid writhing test), respectively. Compound 6c proved to be more active than aspirin with a safety index of 5.1. Topics: Analgesics; Animals; Benzeneacetamides; Cimetidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Histamine Antagonists; Male; Mice; Models, Chemical; Nociceptors; Oxazines; Pyridines; Pyrilamine; Pyrrolidines; Receptors, Opioid; Structure-Activity Relationship	1998

Article

Year

Substituted pyrido[3,2-b]oxazin-3(4H)-ones: synthesis and evaluation of antinociceptive activity.

Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:2

A new series of N-substituted pyrido[3,2-b]oxazinones has been synthesized, pharmacologically evaluated, and compared with acetyl salicylic acid. The compound with the maximal combination of safety and analgesic efficacy was 4-¿3-[4-(4-fluorophenyl-1-piperazinyl)propyl]¿-2H-pyrido[3,2-b]-1, 4-oxazin-3(4H)-one (6c) with ED50 values of 12.5 mg/kg po (mouse: phenylquinone writhing test) and 27.8 mg/kg po (rat: acetic acid writhing test), respectively. Compound 6c proved to be more active than aspirin with a safety index of 5.1.

Topics: Analgesics; Animals; Benzeneacetamides; Cimetidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Histamine Antagonists; Male; Mice; Models, Chemical; Nociceptors; Oxazines; Pyridines; Pyrilamine; Pyrrolidines; Receptors, Opioid; Structure-Activity Relationship

1998