enkephalin--ala(2)-mephe(4)-gly(5)- has been researched along with mitragynine* in 2 studies
2 other study(ies) available for enkephalin--ala(2)-mephe(4)-gly(5)- and mitragynine
| Article | Year |
|---|---|
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
Mitragynine and 7-hydroxymitragynine (7OH) are the major alkaloids mediating the biological actions of the psychoactive plant kratom. To investigate the structure-activity relationships of mitragynine/7OH templates, we diversified the aromatic ring of the indole at the C9, C10, and C12 positions and investigated their G-protein and arrestin signaling mediated by mu opioid receptors (MOR). Three synthesized lead C9 analogs replacing the 9-OCH Topics: Analgesics, Opioid; Animals; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Rats, Sprague-Dawley; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Structure-Activity Relationship | 2021 |
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2020 |