Compounds > enkephalin--ala(2)-mephe(4)-gly(5)-

enkephalin--ala(2)-mephe(4)-gly(5)- and 2-aminotetralin

enkephalin--ala(2)-mephe(4)-gly(5)- has been researched along with 2-aminotetralin* in 1 studies

Other Studies

1 other study(ies) available for enkephalin--ala(2)-mephe(4)-gly(5)- and 2-aminotetralin

Article	Year
[Interaction of tetrahydroisoquinolines and 3-aminotetralines with opioid mu-receptors]. Bioorganicheskaia khimiia, 1991, Volume: 17, Issue:9 The interaction of the tetrahydroisoquinoline (THIQ) and 3-aminotetraline (3-AT derivatives with opioid mu-receptors has been studied. It is shown that THIQ and 3-AT derivatives bind to a site on the mu-receptor which these compounds are likely to share with "classical" opiates, whose structure also includes the 3-AT group. The binding site for nonpeptide substances is in a strong allosteric interaction with the binding site for enkephalins. Some biological effects of THIQ and 3-AT derivatives can be explained in terms of their interaction with opioid receptors. One may speculate that the evolution of the endogenous opioid receptor ligands proceeded from simple 3-AT derivatives towards morphinans and, probably, benzomorphans. Topics: Animals; Binding Sites; Brain; Cell Membrane; Dopamine Agents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Isoquinolines; Rats; Receptors, Opioid; Receptors, Opioid, mu; Temperature; Tetrahydroisoquinolines; Tetrahydronaphthalenes	1991

Article

Year

[Interaction of tetrahydroisoquinolines and 3-aminotetralines with opioid mu-receptors].

Bioorganicheskaia khimiia, 1991, Volume: 17, Issue:9

The interaction of the tetrahydroisoquinoline (THIQ) and 3-aminotetraline (3-AT derivatives with opioid mu-receptors has been studied. It is shown that THIQ and 3-AT derivatives bind to a site on the mu-receptor which these compounds are likely to share with "classical" opiates, whose structure also includes the 3-AT group. The binding site for nonpeptide substances is in a strong allosteric interaction with the binding site for enkephalins. Some biological effects of THIQ and 3-AT derivatives can be explained in terms of their interaction with opioid receptors. One may speculate that the evolution of the endogenous opioid receptor ligands proceeded from simple 3-AT derivatives towards morphinans and, probably, benzomorphans.

Topics: Animals; Binding Sites; Brain; Cell Membrane; Dopamine Agents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Isoquinolines; Rats; Receptors, Opioid; Receptors, Opioid, mu; Temperature; Tetrahydroisoquinolines; Tetrahydronaphthalenes

1991