Page last updated: 2024-08-23

eniluracil and fluorouracil

eniluracil has been researched along with fluorouracil in 89 studies

Research

Studies (89)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	30 (33.71)	18.2507
2000's	54 (60.67)	29.6817
2010's	5 (5.62)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baccanari, DP; Davis, ST; Joyner, SS; Spector, T	1
Cao, S; Rustum, YM; Spector, T	1
Baccanari, DP; Davis, ST; Knick, VC; Spector, T	1
Baccanari, DP; Cao, S; Davis, ST; Joyner, SS; Rustum, YM; Spector, T	1
Drengler, R; Eckardt, J; Eckhardt, G; Villalona-Calero, M; Von Hoff, D	1
Rowinsky, EK	1
Adjei, AA; Baker, SD; Donehower, RC; Doucette, M; Grochow, LB; Hohneker, JA; Khor, SP; Noe, DA; Rowinsky, EK; Sartorius, SE; Spector, T	1
Amyx, H; Baccanari, DP; Davis, ST; Khor, SP; Nelson, D; Spector, T	1
Etienne, MC; Fischel, JL; Formento, P; Milano, G; Renée, N; Spector, T	1
Arellano, M; Malet-Martino, M; Martino, R; Spector, T	1
Burris, HA; Diasio, R; Hohneker, J; Janisch, L; Khor, SP; Lucas, VS; Ratain, MJ; Schilsky, RL; Smetzer, L; Von Hoff, DD	1
Diasio, RB	4
Punt, CJ	1
Brockstein, BE; Haraf, DJ; Humerickhouse, R; Vokes, EE	1
Bunnell, CA; Winer, EP	1
Ajani, JA	1
Hohneker, JA	1
Adams, ER; Craig, DJ; Leffert, JJ; Pizzorno, G; Spector, T	1
Meropol, NJ	1
Brockstein, B; Dolan, ME; Haraf, DJ; Humerickhouse, RA; Kies, M; Ratain, MJ; Stenson, K; Sulzen, L; Vokes, EE	1
González Barón, M	1
Brito, RA; Hoff, PM; Medgyesy, D; Pazdur, R; Ravandi-Kashani, F; Royce, ME; Zukowski, TH	1
Adjei, AA	1
Macdonald, JS	1
Cao, S; Rustum, YM	1
Brito, R; Hoff, PM; Medgyesy, D; Pazdur, R; Royce, M	1
Papamichael, D	1
Baker, SD; Diasio, RB; Donehower, RC; Grochow, LB; Hohneker, JA; Khor, SP; Lucas, VS; O'Reilly, S; Rowinsky, EK; Sartorius, SE; Spector, T	1
Bonny, T; Bukowski, R; Burris, H; Hochster, H; Hohneker, J; Levin, J; Mani, S; O'Rourke, M; Schilsky, RL; Wall, JG	1
Barton, CM; Cirkel, DT; de Boer, RH; Hickish, TF; Johnston, SR; Norton, A; O'Brien, ME; Smith, IE	1
Damjanov, N; Meropol, NJ	1
Hoff, PM; Pazdur, R	1
Aboagye, EO; Brady, F; Jones, T; Lucas, SV; Osman, S; Price, PM; Saleem, A; Suttle, B; Yap, J	1
Beck, T; Bell, WN; Chevlen, EM; Hochster, H; Hohneker, J; Levin, J; Lokich, J; Mani, S; McGuirt, C; O'Rourke, MA; Schilsky, RL; Weaver, CH; White, R	1
Alauddin, MM; Bading, JR; Conti, PS; Fissekis, JD; Joung, J; Shahinian, AH; Spector, T	1
Tewson, TJ	1
Peeters, M; Van Cutsem, E	1
Kindler, HL; Schilsky, RL	1
Baccanari, DP; Cao, S; Davis, ST; Paff, MT; Rustum, YM; Spector, T; Tansik, RL	1
Baker, SD	1
Hohneker, J; Levin, J	1
Bi, DQ; Donavan, S; Grem, JL; Grollman, F; Hamilton, JM; Harold, N; Keith, B; Monahan, BP; Morrison, G; Quinn, MG; Shapiro, J; Takimoto, CH; Zentko, S	1
Cohen, D; Drengler, R; Ertel, VP; Hoffman, C; Hsieh, A; Hurwitz, HI; Magnum, S; Monroe, P; Ochoa, L; Petros, WP; Rowinsky, EK; Schwartz, G; Thomas, JP; Wilding, G	1
Lewis, NL; Meropol, NJ	1
Harboe, K; Lind, A; Ogreid, D; Todnem, K; Zotova, L	1
Hoff, PM; Pazdur, R; Royce, ME	1
Dwivedy, S; Hoff, PM; Medgyesy, D; Pazdur, R; Royce, ME; Zukowski, TH	1
Benson, AB	2
Hollis, D; Mayer, RJ; Meropol, NJ; Niedzwiecki, D; Schilsky, RL	1
Aboagye, EO; Cunningham, VJ; Osman, S; Price, PM; Saleem, A	1
Bruix, J; Castells, L; El-Hariry, I; Llovet, JM; Peachey, M; Ruff, P; Tassopoulos, N	1
Dougherty, DS; Grem, JL; Harold, N; Keith, B; Saif, MW; Wilson, RH	1
Browman, G; Clarke, R; Cooke, A; Cripps, C; Goss, G; Khoo, K; Klaassen, D; Knowling, M; Matthews, S; Seymour, L; Siu, L; Tannock, I	1
Coleman, R; Cunningham, D	1
Barton, CM; Bonneterre, J; Cirkel, DT; Davidson, NG; Piccart, MJ; Richel, DJ; Skovsgaard, T	1
Lokich, J	1
Colwell, B; Conklin, HS; Frye, D; Graham, M; Hortobagyi, GN; Levin, J; McGuirt, C; Rivera, E; Somerville, M; Sutton, L	1
Ansari, RH; Bell, WN; Colwell, B; Levin, J; McGuirt, PV; Pazdur, R; Schilsky, RL; Thirlwell, MP; West, WH; White, RL; Wong, A; Yates, BB	1
Adjei, AA; Alberts, SR; Ames, MM; Atherton, P; Diasio, RB; Erlichman, C; Goldberg, RM; Hanson, LJ; Pitot, HC; Reid, JM; Rubin, J; Sloan, JA; Smith, DA	1
Ertel, P; Fleming, GF; Janisch, L; Kastrissios, H; Learned-Coughlin, S; Magnum, S; Mani, S; Ratain, MJ; Schilsky, RL; Shepard, DR; Smith, D	1
Grem, JL; Guo, XD; Harold, N; Keith, B; Quinn, M; Schuler, B; Shapiro, J; Zentko, S	1
Booser, DJ; Cristofanilli, M; Frye, DK; Hortobagyi, GN; Rivera, E; Rosales, MM; Valero, V	1
Abramson, N; Benson, AB; Bonny, T; Burnhan, JP; Hohneker, J; Klencke, B; Levin, J; McGuirt, C; Mitchell, E; Ritch, P	1
Abbruzzese, JL; Benedetti, JK; George, CS; Giguere, JK; Macdonald, JS; Neubauer, MA; Pruitt, BT; Rothenberg, ML; Seay, TE; Tanaka, MS	1
Baker, MN; Barton, JH; Burris, HA; Greco, FA; Hainsworth, JD; Jones, SF; Levin, J; McGuirt, PV; Patton, JW; Willcutt, NT	1
Fishman, AD; Wadler, S	1
Alberti, D; Arzoomanian, RZ; Bailey, H; Berlin, JD; Binger, K; Feierabend, C; Marrocha, R; Morgan-Meadows, S; Mulkerin, D; Thomas, JP; Volkman, J; Wilding, G	1
Abbruzzese, JL; Budd, GT; Chansky, K; Doukas, MA; Giguere, JK; Leichman, CG; Macdonald, JS	1
Benson, AB; Catalano, P; Cornfeld, MJ; Graham, DL; Huang, J; Marsh, JC; O'Dwyer, PJ	1
Schilsky, RL	1
Baker, SD; Donehower, RC; Grochow, LB; Rowinsky, EK; Schellens, JH; Sparreboom, A; Verweij, J	1
Beale, P; Ertel, P; Judson, I; O'Donnell, A; Punt, CJ; Suttle, AB; Van Maanen, L	1
Gottfried, MR; Jones, R; Kypson, AP; Morphew, E; Seigler, HF	1
Cliatt, J; Grem, JL; Grollman, F; Guo, XD; Hamilton, JM; Harold, N; McQuigan, EA; Monahan, BP; Nguyen, D; Quinn, MG; Saif, MW; Schuler, B; Szabo, E; Takimoto, CH; Thomas, RR; Wilson, R	1
Harper, P; Holford, C; Karapetis, C; Knight, S; Steer, C; Strickland, AH; Yip, D	1
Hoff, PM	1
Anscher, MS; Cohen, DP; Czito, BG; Ertel, PJ; Honeycutt, W; Hong, TJ; Hurwitz, HI; Lee, CG; Lockhart, AC; Ludwig, KA; Mangum, SG; Mantyh, C; Morse, MA; Petros, WP; Seigler, HF; Spector, NL; Tyler, DS	1
Cohen, DP; Czito, BG; Fernando, N; Hong, TJ; Hurwitz, HI; Lee, CG; Lockhart, AC; Morse, MA; Pappas, TN; Petros, WP; Tyler, DS; Yu, D	1
Geboes, K; Van Cutsem, E	1
Cao, S; Spector, T	1
Chen, J; Zhou, M	1
Chang, AY; de Lima Lopes, G; Dicksey, JS; Palalay, M; Peters, WP	1
Burdaeva, O; Chang, JC; Kirby, MG; Rivera, E; Semiglazov, V; Spector, T	1
Chionh, F; Lau, D; Price, T; Tebbutt, N; Yeung, Y	1

Reviews

35 review(s) available for eniluracil and fluorouracil

Article	Year
New anticancer agents in clinical development. Oncology (Williston Park, N.Y.), 1995, Volume: 9, Issue:12 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Gemcitabine; Humans; Neoplasms; Polysaccharides, Bacterial; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidylate Synthase; Uracil	1995
The suitability of selected new anticancer agents for infusional therapy and the effects of others on infusional therapy practices. The Journal of infusional chemotherapy, 1995,Fall, Volume: 5, Issue:4 Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Dihydrouracil Dehydrogenase (NADP); Drug Delivery Systems; Enzyme Inhibitors; Fluorouracil; Humans; Infusions, Parenteral; Neoplasms; Oxidoreductases; Topoisomerase I Inhibitors; Uracil	1995
New drugs in the treatment of colorectal carcinoma. Cancer, 1998, Aug-15, Volume: 83, Issue:4 Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Topotecan; Trimetrexate; Uracil	1998
Oral 5-FU alternatives for the treatment of head and neck cancer. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Etoposide; Fluorouracil; Head and Neck Neoplasms; Humans; Hydroxyurea; Neoplasm Recurrence, Local; Tegafur; Uracil	1998
Oral 5-FU analogues in the treatment of breast cancer. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Enzyme Inhibitors; Female; Fluorouracil; Humans; Tegafur; Uracil	1998
Chemotherapy for gastric carcinoma: new and old options. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7 Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Drug Combinations; Enzyme Inhibitors; Etoposide; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Oxonic Acid; Paclitaxel; Pyridines; Randomized Controlled Trials as Topic; Stomach Neoplasms; Taxoids; Tegafur; Uracil	1998
Clinical development of eniluracil: current status. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Pancreatic Neoplasms; Treatment Outcome; Uracil	1998
Oral fluoropyrimidines in the treatment of colorectal cancer. European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:10 Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Pyridines; Tegafur; Uracil	1998
[Oral fluoropyrimidines in oncology]. Anales de la Real Academia Nacional de Medicina, 1998, Volume: 115, Issue:3 Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil	1998
Fluoropyrimidines: a critical evaluation. Oncology, 1999, Volume: 57 Suppl 1 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Pyridines; Tegafur; Uracil	1999
Clinical implications of dihydropyrimidine dehydrogenase inhibition. Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:7 Suppl 3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Dihydrouracil Dehydrogenase (NADP); Drug Evaluation; Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Tegafur; Uracil	1999
A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer. British journal of clinical pharmacology, 1999, Volume: 48, Issue:3 Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Glutamates; Guanine; Humans; Pemetrexed; Platinum Compounds; Pyridines; Quinazolines; Tegafur; Thiophenes; Uracil	1999
Oral fluoropyrimidines: a closer look at their toxicities. American journal of clinical oncology, 1999, Volume: 22, Issue:5 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Tegafur; Uracil	1999
New drugs in therapy of colorectal cancer: preclinical studies. Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Oxidoreductases; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidine Phosphorylase; Thymidylate Synthase; Uracil	1999
Oral fluoropoyrimidines. Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Leucovorin; Oxidoreductases; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil	1999
The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status. The oncologist, 1999, Volume: 4, Issue:6 Topics: Antineoplastic Agents; Colorectal Neoplasms; Enzyme Inhibitors; Fluorouracil; Humans; Prodrugs; Thymidylate Synthase; Uracil	1999
Oral therapy for colorectal cancer: how to choose. Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:6 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Availability; Capecitabine; Colorectal Neoplasms; Decision Making; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Tegafur; Uracil	2000
Dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines: a novel class of oral antineoplastic agents. Seminars in oncology, 1999, Volume: 26, Issue:6 Suppl 18 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Uracil	1999
Oral fluoropyrimidines in colorectal cancer. Seminars in oncology, 2000, Volume: 27, Issue:5 Suppl 10 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Pyridines; Tegafur; Uracil	2000
Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert opinion on investigational drugs, 2000, Volume: 9, Issue:7 Topics: Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Uracil	2000
Preclinical development of eniluracil: enhancing the therapeutic index and dosing convenience of 5-fluorouracil. Investigational new drugs, 2000, Volume: 18, Issue:4 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil	2000
Pharmacology of fluorinated pyrimidines: eniluracil. Investigational new drugs, 2000, Volume: 18, Issue:4 Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil	2000
Clinical development of eniluracil/fluorouracil: an oral treatment for patients with solid tumors. Investigational new drugs, 2000, Volume: 18, Issue:4 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Uracil	2000
Oral fluoropyrimidines in cancer treatment. Cancer investigation, 2000, Volume: 18, Issue:8 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Head and Neck Neoplasms; Humans; Lung Neoplasms; Neoplasms; Pyridines; Stomach Neoplasms; Tegafur; Uracil	2000
[Fluorinated pyrimidines in oral treatment of advanced colorectal cancer]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2000, Sep-30, Volume: 120, Issue:23 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Prodrugs; Pyrimidines; Tegafur; Uracil	2000
Novel oral chemotherapy agents. Current oncology reports, 2000, Volume: 2, Issue:1 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Dacarbazine; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Neoplasms; Tegafur; Temozolomide; Uracil	2000
Colorectal cancer: chemotherapy treatment overview. Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:12 Suppl 1 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Treatment Outcome; Uracil	2000
Oral eniluracil/5-FU for advanced colon and breast carcinomas. Oncology (Williston Park, N.Y.), 2001, Volume: 15, Issue:1 Suppl 2 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Forecasting; Humans; Oxidoreductases; Uracil	2001
New options for outpatient chemotherapy--the role of oral fluoropyrimidines. Cancer treatment reviews, 2001, Volume: 27, Issue:4 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Humans; Outpatients; Tegafur; Uracil	2001
Advances in the treatment of metastatic colorectal cancer. Clinical colorectal cancer, 2001, Volume: 1, Issue:1 Topics: Administration, Oral; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cancer Vaccines; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Prodrugs; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Uracil	2001
Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism. Journal of surgical oncology, 2003, Volume: 82, Issue:2 Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Colectomy; Enzyme Inhibitors; Female; Fibroblast Growth Factor 2; Fluorouracil; Humans; Immunohistochemistry; Neoadjuvant Therapy; Ossification, Heterotopic; Radiotherapy, Adjuvant; Rectal Neoplasms; Transforming Growth Factor beta; Treatment Outcome; Uracil	2003
Practical considerations in the use of oral fluoropyrimidines. Seminars in oncology, 2003, Volume: 30, Issue:3 Suppl 6 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil	2003
The multidisciplinary management of gastrointestinal cancer. The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer. Best practice & research. Clinical gastroenterology, 2007, Volume: 21, Issue:6 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Death; Cell Survival; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; ErbB Receptors; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Tegafur; Treatment Outcome; Uracil; Vascular Endothelial Growth Factor A	2007
Applications of oral fluoropyrimidines in colon cancer: their role and new directions. Journal of the National Comprehensive Cancer Network : JNCCN, 2003, Volume: 1 Suppl 3 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Oxaloacetates; Oxonic Acid; Tegafur; Uracil	2003
Oral versus intravenous fluoropyrimidines for colorectal cancer. The Cochrane database of systematic reviews, 2017, Jul-28, Volume: 7 Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil	2017

Trials

31 trial(s) available for eniluracil and fluorouracil

Article	Year
Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:12 Topics: Absorption; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Dihydrouracil Dehydrogenase (NADP); Enzyme Activation; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Oxidoreductases; Tissue Distribution; Uracil	1996
Phase I clinical and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Leucovorin; Male; Middle Aged; Neoplasms; Oxidoreductases; Uracil	1998
Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:2 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Feasibility Studies; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Oxidoreductases; Radiography; Treatment Outcome; Uracil	1999
Phase I and pharmacologic study of oral fluorouracil on a chronic daily schedule in combination with the dihydropyrimidine dehydrogenase inactivator eniluracil. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:4 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Diarrhea; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Follow-Up Studies; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Oxidoreductases; Remission Induction; Tissue Distribution; Uracil	2000
A multicenter phase II study of a five-day regimen of oral 5-fluorouracil plus eniluracil with or without leucovorin in patients with metastatic colorectal cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:4 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Treatment Outcome; Uracil	2000
Low-dose oral fluorouracil with eniluracil as first-line chemotherapy against advanced breast cancer: a phase II study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:12 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biological Availability; Breast Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Middle Aged; Treatment Outcome; Uracil	2000
Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action. Lancet (London, England), 2000, Jun-17, Volume: 355, Issue:9221 Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Gastrointestinal Neoplasms; Half-Life; Humans; Injections, Intravenous; Liver; Male; Middle Aged; Oxidoreductases; Tissue Distribution; Tomography, Emission-Computed; Uracil	2000
Multicenter phase II study to evaluate a 28-day regimen of oral fluorouracil plus eniluracil in the treatment of patients with previously untreated metastatic colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:15 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Drug Synergism; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Outpatients; Treatment Outcome; Uracil	2000
Phase I and pharmacokinetic trial of weekly oral fluorouracil given with eniluracil and low-dose leucovorin to patients with solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Dec-01, Volume: 18, Issue:23 Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Oxidoreductases; Uracil	2000
Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies. Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:10 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Oxidoreductases; Therapeutic Equivalency; Uracil	2000
Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma. Cancer, 2001, Apr-01, Volume: 91, Issue:7 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NAD+); Disease Progression; Enzyme Inhibitors; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Thymidylate Synthase; Uracil	2001
A phase II trial of oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma. European journal of cancer (Oxford, England : 1990), 2001, Volume: 37, Issue:11 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Fluorouracil; Follow-Up Studies; Humans; Liver Neoplasms; Male; Middle Aged; Survival Rate; Uracil	2001
A National Cancer Institute of Canada clinical trials group phase II study of eniluracil (776C85) and oral 5-fluorouracil in patients with advanced squamous cell head and neck cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:7 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Canada; Enzyme Inhibitors; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Squamous Cell; Treatment Outcome; Uracil	2001
A phase II study of oral eniluracil/fluorouracil in patients with anthracycline-refractory or anthracycline- and taxane-refractory advanced breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:9 Topics: Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Bridged-Ring Compounds; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Middle Aged; Taxoids; Treatment Outcome; Uracil	2001
Multicenter phase II study of a 28-day regimen of orally administered eniluracil and fluorouracil in the treatment of patients with anthracycline- and taxane-resistant advanced breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Feb-15, Volume: 20, Issue:4 Topics: Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Bridged-Ring Compounds; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fluorouracil; Humans; Infusions, Intravenous; Middle Aged; Patient Compliance; Taxoids; Treatment Outcome; Uracil	2002
Randomized, open-label, phase III study of a 28-day oral regimen of eniluracil plus fluorouracil versus intravenous fluorouracil plus leucovorin as first-line therapy in patients with metastatic/advanced colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Mar-15, Volume: 20, Issue:6 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Drug Synergism; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Proportional Hazards Models; Survival Analysis; Treatment Outcome; Uracil	2002
Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Mar-15, Volume: 20, Issue:6 Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cross-Over Studies; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Oxidoreductases; Uracil	2002
Estimation of the effect of food on the disposition of oral 5-fluorouracil in combination with eniluracil. Cancer chemotherapy and pharmacology, 2002, Volume: 49, Issue:5 Topics: Aged; Antineoplastic Agents; Area Under Curve; Cross-Over Studies; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Food-Drug Interactions; Humans; Intestinal Absorption; Male; Middle Aged; Models, Biological; Oxidoreductases; Population; Therapeutic Equivalency; Uracil	2002
Impact of two weekly schedules of oral eniluracil given with fluorouracil and leucovorin on the duration of dihydropyrimidine dehydrogenase inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:5 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasms; Oxidoreductases; Time Factors; Uracil	2002
Phase I study of eniluracil and oral 5-fluorouracil in combination with docetaxel in the treatment of patients with metastatic breast carcinoma. Cancer, 2002, May-01, Volume: 94, Issue:9 Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Paclitaxel; Taxoids; Uracil	2002
Oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma. Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Volume: 13, Issue:4 Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Diarrhea; Enzyme Inhibitors; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Treatment Outcome; Uracil	2002
Phase II trial of 5-fluorouracil plus eniluracil in patients with advanced pancreatic cancer: a Southwest Oncology Group study. Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Volume: 13, Issue:10 Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neutropenia; Pancreatic Neoplasms; Survival; Treatment Outcome; Uracil	2002
A phase I trial of weekly paclitaxel plus prolonged oral eniluracil/5-fluorouracil in patients with refractory malignancies. The oncologist, 2002, Volume: 7, Issue:5 Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Paclitaxel; Treatment Outcome; Uracil	2002
Phase I study of eniluracil, oral 5-fluororacil and gemcitabine in patients with advanced malignancy. Investigational new drugs, 2002, Volume: 20, Issue:4 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Humans; Lymphoma; Male; Middle Aged; Neoplasms; Patients; Uracil	2002
Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer. Investigational new drugs, 2002, Volume: 20, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antineoplastic Protocols; Colorectal Neoplasms; Confidence Intervals; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Oxidoreductases; Southwestern United States; Survival Rate; Treatment Failure; Uracil	2002
Eastern Cooperative Oncology Group phase II trial (E4296) of oral 5-fluorouracil and eniluracil as a 28-day regimen in metastatic colorectal cancer. Clinical colorectal cancer, 2002, Volume: 2, Issue:1 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Confidence Intervals; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Survival Analysis; Uracil	2002
Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule. Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:1 Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Enzyme Inhibitors; Female; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Leucovorin; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Uracil	2003
A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon. International journal of radiation oncology, biology, physics, 2004, Mar-01, Volume: 58, Issue:3 Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colonic Neoplasms; Combined Modality Therapy; Drug Combinations; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Rectal Neoplasms; Uracil	2004
A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. Cancer investigation, 2006, Volume: 24, Issue:1 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoadjuvant Therapy; Pancreatic Neoplasms; Radiotherapy; Treatment Outcome; Uracil	2006
Final results of a prematurely discontinued Phase 1/2 study of eniluracil with escalating doses of 5-fluorouracil administered orally in patients with advanced hepatocellular carcinoma. Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:4 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asian People; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Treatment Outcome; Uracil	2011
Eniluracil plus 5-fluorouracil and leucovorin: treatment for metastatic breast cancer patients in whom capecitabine treatment rapidly failed. Clinical breast cancer, 2014, Volume: 14, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Neoplasm Metastasis; Treatment Failure; Uracil	2014

Other Studies

23 other study(ies) available for eniluracil and fluorouracil

Article	Year
5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs. Biochemical pharmacology, 1994, Jul-19, Volume: 48, Issue:2 Topics: Animals; beta-Alanine; Central Nervous System Diseases; Dihydrouracil Dehydrogenase (NADP); Dogs; Dose-Response Relationship, Drug; Fluorouracil; Infusions, Intravenous; Male; Oxidoreductases; Uracil	1994
5-Ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer research, 1994, Mar-15, Volume: 54, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Synergism; Female; Fluorouracil; Leucovorin; Neoplasm Transplantation; Phosphonoacetic Acid; Rats; Rats, Inbred F344; Uracil	1994
5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil. Proceedings of the National Academy of Sciences of the United States of America, 1993, Dec-01, Volume: 90, Issue:23 Topics: Administration, Oral; Animals; Biological Availability; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Female; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasms, Experimental; Oxidoreductases; Plasmacytoma; Rats; Therapeutic Equivalency; Uracil	1993
5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil. Cancer research, 1995, Dec-15, Volume: 55, Issue:24 Topics: Animals; Carcinoma; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Male; Neoplasm Transplantation; Oxidoreductases; Prodrugs; Rats; Tegafur; Uracil	1995
Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans. Cancer chemotherapy and pharmacology, 1997, Volume: 39, Issue:3 Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Dogs; Fluorouracil; Humans; Mice; Models, Chemical; Oxidoreductases; Rats; Uracil	1997
Dual modulation of 5-fluorouracil cytotoxicity using folinic acid with a dihydropyrimidine dehydrogenase inhibitor. Biochemical pharmacology, 1997, Jun-01, Volume: 53, Issue:11 Topics: Cell Survival; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Thymidylate Synthase; Tumor Cells, Cultured; Uracil	1997
5-Ethynyluracil (GW776): effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model. British journal of cancer, 1997, Volume: 76, Issue:9 Topics: Animals; Bile; Enzyme Inhibitors; Fluoroacetates; Fluorouracil; In Vitro Techniques; Lactic Acid; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Uracil	1997
Improving 5-FU with a novel dihydropyrimidine dehydrogenase inactivator. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:3 Suppl 4 Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil	1998
In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy. Cancer research, 1999, Jan-01, Volume: 59, Issue:1 Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oxidoreductases; Uracil	1999
UFT and eniluracil, oral variations of 5-FU, offer lower toxicity, phase II results show. The oncologist, 1999, Volume: 4, Issue:1 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Breast Neoplasms; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Female; Fluorouracil; Humans; Prodrugs; Uracil	1999
Blocking catabolism with eniluracil enhances PET studies of 5-[18F]fluorouracil pharmacokinetics. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2000, Volume: 41, Issue:10 Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Female; Fluorine Radioisotopes; Fluorouracil; Radiopharmaceuticals; Rats; Rats, Inbred F344; Tomography, Emission-Computed; Uracil	2000
Enzyme inhibition as an aid to simplify pharmacokinetic measurements? Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2000, Volume: 41, Issue:10 Topics: Animals; Antimetabolites, Antineoplastic; Enzyme Inhibitors; Fluorine Radioisotopes; Fluorouracil; Radiopharmaceuticals; Rats; Uracil	2000
Extraction of 5-fluorouracil by tumor and liver: a noninvasive positron emission tomography study of patients with gastrointestinal cancer. Cancer research, 2001, Jul-01, Volume: 61, Issue:13 Topics: Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorine Radioisotopes; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver; Liver Neoplasms; Models, Biological; Oxidoreductases; Pancreatic Neoplasms; Tomography, Emission-Computed; Uracil	2001
Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil. Anti-cancer drugs, 2001, Volume: 12, Issue:6 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Electromyography; Female; Fluorouracil; Humans; Leucovorin; Magnetic Resonance Imaging; Male; Middle Aged; Oxidoreductases; Peripheral Nervous System Diseases; Time Factors; Uracil	2001
Oral fluoropyrimidines: are they the equivalent of parenteral infusional 5-fluorouracil? Cancer investigation, 2001, Volume: 19, Issue:8 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Infusions, Intravenous; Tegafur; Uracil	2001
An evolving role for oral fluoropyrimidine drugs. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Feb-15, Volume: 20, Issue:4 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Therapy; Enzyme Inhibitors; Female; Fluorouracil; Humans; Pyrimidines; Uracil	2002
Inhibiting 5-fluorouracil breakdown: a broken down approach to 5-fluorouracil modulation. Clinical colorectal cancer, 2002, Volume: 2, Issue:1 Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil	2002
Can eniluracil improve 5-fluorouracil therapy? Clinical colorectal cancer, 2002, Volume: 2, Issue:1 Topics: Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil	2002
Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. Journal of the National Cancer Institute, 2002, Dec-18, Volume: 94, Issue:24 Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Surface Area; Clinical Trials, Phase I as Topic; Cytosine; Dacarbazine; Dioxolanes; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Administration Schedule; Drugs, Investigational; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Paclitaxel; Retrospective Studies; Temozolomide; Uracil	2002
A study to evaluate the pharmacokinetics of oral 5-fluorouracil and eniluracil after concurrent administration to patients with refractory solid tumours and varying degrees of renal impairment (FUMA1005). Cancer chemotherapy and pharmacology, 2003, Volume: 51, Issue:1 Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Drug Therapy, Combination; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Renal Insufficiency; Uracil	2003
A dose-escalating study of oral eniluracil/5-fluorouracil plus oxaliplatin in patients with advanced gastrointestinal malignancies. Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:6 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Uracil	2003
A possible cause and remedy for the clinical failure of 5-fluorouracil plus eniluracil. Clinical colorectal cancer, 2010, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluorouracil; Neoplasms, Experimental; Rats; Rats, Inbred F344; Uracil	2010
Determination of eniluracil and 5-fluorouracil in human plasma by LC-MS/MS. Bioanalysis, 2010, Volume: 2, Issue:12 Topics: Chromatography, High Pressure Liquid; Enzyme Inhibitors; Fluorouracil; Humans; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity; Uracil	2010