endothelin-1 has been researched along with sulforaphane* in 1 studies
1 other study(ies) available for endothelin-1 and sulforaphane
| Article | Year |
|---|---|
Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium.
Nrf2 is a master regulator of antioxidant cellular defence, and agents activating the Nrf2 pathway have been tested in various diseases. However, unexpected side effects of cardiovascular nature reported for bardoxolone methyl in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease (the BEACON trial) still have not been fully explained. Here, we aimed to characterize the effects of bardoxolone methyl compared with other Nrf2 activators-dimethyl fumarate and L-sulforaphane-on human microvascular endothelium. Endothelial toxicity, bioenergetics, mitochondrial membrane potential, endothelin-1 (ET-1) release, endothelial permeability, Nrf2 expression, and ROS production were assessed in human microvascular endothelial cells (HMEC-1) incubated for 3 and 24 hours with 100 nM-5 Topics: Cell Line; Cell Survival; Dimethyl Fumarate; Down-Regulation; Endothelial Cells; Endothelin-1; Gene Expression; Humans; Isothiocyanates; Membrane Potential, Mitochondrial; Microvessels; Mitochondria; NF-E2-Related Factor 2; Oleanolic Acid; Permeability; Reactive Oxygen Species; Sulfoxides | 2020 |