endomorphin-2 has been researched along with 1-2-3-4-tetrahydroisoquinoline-3-carboxylic-acid* in 1 studies
1 other study(ies) available for endomorphin-2 and 1-2-3-4-tetrahydroisoquinoline-3-carboxylic-acid
| Article | Year |
|---|---|
[TIC4]endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings.
[Tic(4)]EM1 and [Tic(4)]EM2, new endomorphins (EMs) analogues, caused relaxation of rat aorta rings precontracted with phenylphrine in a concentration-dependent manner and were 240- to 370-fold more potent than EMs. This effect was inhibited by endothelium removal or by incubation with NO synthase inhibitor L-NNA or opioid receptor antagonist naloxone. The results demonstrate that [Tic(4)]EMs have NO- and endothelium-dependent vasorelaxant effects which are mediated by the opioid receptor. Topics: Animals; Aorta; Dose-Response Relationship, Drug; In Vitro Techniques; Nitric Oxide Synthase; Nitroarginine; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu; Tetrahydroisoquinolines; Vasodilation | 2005 |