enalaprilat-anhydrous and idrapril

enalaprilat-anhydrous has been researched along with idrapril* in 1 studies

Other Studies

1 other study(ies) available for enalaprilat-anhydrous and idrapril

Article	Year
Inhibition of rabbit lung angiotensin converting enzyme by idrapril. Biochemical pharmacology, 1993, Mar-24, Volume: 45, Issue:6 Idrapril, the prototype of a new class of angiotensin converting enzyme (ACE) inhibitors, competitively inhibited, with nanomolar apparent Ki, the hydrolysis of hippuryl-glycyl-glycine by rabbit lung ACE. The pre-steady-state analysis of this tight-binding inhibition showed it to be characterized by slow kinetics, but at variance with what was found for enalaprilat in the same conditions, idrapril appeared to act through a simple, single step mechanism. Kinetic Ki and k(on) and k(off) values were 470 pM, 3.0 +/- 1.5 x 10(6) M-1 sec-1 and 1.4 +/- 0.3 x 10(-3) sec-1, respectively. Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Binding, Competitive; Cyclohexanecarboxylic Acids; Dipeptides; Dose-Response Relationship, Drug; Enalaprilat; Hydroxylamines; Kinetics; Lisinopril; Lung; Peptidyl-Dipeptidase A; Rabbits	1993

Article

Year

Inhibition of rabbit lung angiotensin converting enzyme by idrapril.

Biochemical pharmacology, 1993, Mar-24, Volume: 45, Issue:6

Idrapril, the prototype of a new class of angiotensin converting enzyme (ACE) inhibitors, competitively inhibited, with nanomolar apparent Ki, the hydrolysis of hippuryl-glycyl-glycine by rabbit lung ACE. The pre-steady-state analysis of this tight-binding inhibition showed it to be characterized by slow kinetics, but at variance with what was found for enalaprilat in the same conditions, idrapril appeared to act through a simple, single step mechanism. Kinetic Ki and k(on) and k(off) values were 470 pM, 3.0 +/- 1.5 x 10(6) M-1 sec-1 and 1.4 +/- 0.3 x 10(-3) sec-1, respectively.

Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Binding, Competitive; Cyclohexanecarboxylic Acids; Dipeptides; Dose-Response Relationship, Drug; Enalaprilat; Hydroxylamines; Kinetics; Lisinopril; Lung; Peptidyl-Dipeptidase A; Rabbits

1993