enalaprilat-anhydrous and allyl-sulfide

Cytochrome P450 family 2 subfamily E member 1 (CYP2E1) is a member of the cytochrome P450 enzyme family and catalyzes the metabolism of various substrates. CYP2E1 is upregulated in multiple heart diseases and causes damage mainly via the production of reactive oxygen species (ROS). In mice, increased CYP2E1 expression induces cardiac myocyte apoptosis, and knockdown of endogenous CYP2E1 can attenuate the pathological development of dilated cardiomyopathy (DCM). Nevertheless, targeted inhibition of CYP2E1 via the administration of drugs for the treatment of DCM remains elusive. Therefore, the present study aimed to investigate whether diallyl sulfide (DAS), a competitive inhibitor of CYP2E1, can be used to inhibit the development of the pathological process of DCM and identify its possible mechanism. Here, cTnT

Topics: Allyl Compounds; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Cardiomyopathy, Dilated; Cardiotonic Agents; Cell Line; Cytochrome P-450 CYP2E1; Disease Models, Animal; Enalaprilat; Female; Male; Mice, Transgenic; Mitochondria; Oxidative Stress; Rats; Sulfides; Troponin T