Page last updated: 2024-08-24

enadoline and benzofurans

enadoline has been researched along with benzofurans in 78 studies

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	61 (78.21)	18.2507
2000's	15 (19.23)	29.6817
2010's	2 (2.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Pinnock, RD	2
Callahan, MJ; Davis, RE; Dickerson, M; Downs, DA	1
Kusumoto, K; Mackay, KB; McCulloch, J	1
Hughes, J; Hunter, JC; Singh, L; Vass, CA; Woodruff, GN	1
Boyle, SJ; Horwell, DC; Hughes, J; Hunter, JC; Leighton, GE; Meecham, KG; Rees, DC	1
Hayes, ES; Pugsley, MK; Saint, DA; Walker, MJ	1
Browne, SE; Bullock, R; Dawson, D; Fujisawa, H; MacKay, KB; McCulloch, J	1
Brotchie, JM; Crossman, AR; Maneuf, YP; Mitchell, IJ; Woodruff, GN	1
Abood, ME; McLaughlin, CR; Tao, Q	1
Chapman, AG; Meldrum, BS; Millan, MH	1
Butelman, ER; France, CP; Woods, JH	1
Benicourt, C; Junien, JL; Lockhart, BP; Privat, A; Soulard, P	1
Clarke, GD; Zaratin, P	1
Dawkins, R; Rajagopalan, R; Reece, PA; Rose, S; Sedman, AJ; Wright, DS	1
Conover, JR; DeCoster, MA; Hunter, JC; Tortella, FC	1
France, CP; Gerak, LR	1
Atwal, P; Hunter, JC; Singh, L; Woodruff, GN	1
Dykstra, LA; Pitts, RC	1
Mackay, KB; McCulloch, J	1
Martin, BR; Smith, PB; Welch, SP	1
Picker, MJ	1
Headley, PM; Herrero, JF	1
Hughes, J; Oles, R; Poat, J; Woodburn, VL; Woodruff, GN	1
Hayward, NJ; McKnight, AT; Woodruff, GN	2
Graham, DI; Kusumoto, K; Mackay, KB; McCulloch, J	2
Hayward, NJ; Hughes, J; Poat, JA; Woodburn, VL; Woodruff, GN	1
Penz, MP; Pugsley, MK; Saint, DA; Walker, MJ	1
Brotchie, JM; Hill, MP	3
Brandt, MR; France, CP	1
Basbaum, AI; Gogas, KR; Levine, JD	1
Galbraith, SL; MacKay, KB; McCulloch, J; Patel, TR; Woodruff, GN	1
Hjorth, SA; Schwartz, TW; Thirstrup, K	1
Benjamin, R; Cooper, SA; Greiner, M; Pande, AC; Pierce, MW; Pyke, RE	1
Benjamin, R; Greiner, M; Pande, AC; Pierce, MW; Pyke, RE; Wideman, GL	1
Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ	1
Hughes, J; Panegyres, PK	1
Hughes, J; Hunter, JC; Moreton, JE; Robles, L; Rose, J; Tortella, FC	1
Rothe, KS; Stevens, CW	1
DeCoster, MA; Tortella, FC	1
Brotchie, JM; Crossman, AR; Hill, MP; Hughes, NR; McKnight, AT; Woodruff, GN	1
Butelman, ER; Ko, MC; Mosberg, HI; Sobczyk-Kojiro, K; Van Bemmel, B; Woods, JH; Zernig, G	1
Chambers, JP; Evans, RH; Faber, ES	1
Panegyres, PK	1
Boudinot, E; Denavit-Saubié, M; Foutz, AS; Kieffer, BL; Maldonado, R; Matthes, HW; Negri, L; Roques, BP; Severini, C; Smadja, C; Valverde, O; Vonesch, JL	1
Black, D; Trevethick, M	1
Broqua, P; Dahl, SG; Rivière, PJ; Rocher, MN; Wettstein, JG	1
Antelo, MT; Fernández, B; Kitchen, I; Viveros, MP	1
Becker, A; Braun, H; Grecksch, G; Höllt, V; Schröder, H	1
Newman, LC; Stevens, CW	1
McDougall, SA; Nazarian, A; Rodarte-Freeman, AL	1
Carnell, AJ; Field, MJ; Gonzalez, MI; Hughes, J; McCleary, S; Oles, RJ; Singh, L; Smith, R	1
Desor, D; Grasmück, V; Joyeux, M; Langlois, A; Messaoudi, M; Roman, FJ	1
Holtzman, SG; Powell, KR	2
Corbett, AD; Davies, MR; Glen, T; Menzies, JR; Paterson, SJ	1
Höllt, V; Rauca, C; Schäfer, K	1
Hinton, JP; Hudson, G	1
Dworzak, D; Platzer, S; Schadrack, J; Spanagel, R; Tölle, TR; Winkler, A; Zieglgänsberger, W	1
Hahn, B; Shoaib, M; Stolerman, IP	1
Henniger, MS; Hölter, SM; Lipkowski, AW; Spanagel, R	1
Bergman, J; Carey, GJ	1
Chen, Z; Clarke, S; Hill, R; Hsu, MS; Kitchen, I; Pintar, J	1
Bigelow, GE; Geter-Douglas, B; Strain, EC; Walsh, SL	1
Abreu, ME; Bigelow, GE; Strain, EC; Walsh, SL	1
Barrett, AC; Cook, CD; Picker, MJ; Roach, EL; Syvanthong, C; Terner, JM	1
Filliol, D; Goody, RJ; Kieffer, BL; Kitchen, I; Oakley, SM	1
Nylander, I; Ploj, K	1
Kamei, J; Ohsawa, M	1
Bailey, A; Gianotti, R; Ho, A; Kreek, MJ	1
Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Spealman, RD; Valdez, GR	1
Bergman, J; Gilman, JP; Goldberg, SR; Graczyk, Z; Mello, NK; Negus, SS; Schindler, CW	1
Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Spealman, RD	1
Athayde, ML; Boligon, AA; Bonacorso, HG; Calixto, JB; Ferreira, J; Machado, P; Martins, MA; Oliveira, SM; Rosa, F; Rossato, MF; Rubin, MA; Silva, CR; Tonello, R; Trevisan, G; Walker, CI; Zanatta, N	1

Reviews

1 review(s) available for enadoline and benzofurans

Article	Year
Kappa opioids: therapeutic considerations in epilepsy and CNS injury. Clinical neuropharmacology, 1994, Volume: 17, Issue:5 Topics: Analgesics, Opioid; Animals; Anticonvulsants; Benzofurans; Central Nervous System Diseases; Epilepsy; Humans; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Thiophenes	1994

Trials

5 trial(s) available for enadoline and benzofurans

Article	Year
Diuretic effects, pharmacokinetics, and safety of a new centrally acting kappa-opioid agonist (CI-977) in humans. Journal of clinical pharmacology, 1994, Volume: 34, Issue:11 Topics: Adult; Benzofurans; Cross-Over Studies; Diuretics; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyrrolidines; Receptors, Opioid, kappa	1994
Analgesic efficacy of the kappa-receptor agonist, enadoline, in dental surgery pain. Clinical neuropharmacology, 1996, Volume: 19, Issue:1 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Benzofurans; Codeine; Double-Blind Method; Drug Combinations; Humans; Male; Molar, Third; Pain, Postoperative; Pyrrolidines; Receptors, Opioid, kappa; Tooth Extraction	1996
Analgesic efficacy of enadoline versus placebo or morphine in postsurgical pain. Clinical neuropharmacology, 1996, Volume: 19, Issue:5 Topics: Abdomen; Acetaminophen; Adult; Analgesia; Analgesia, Obstetrical; Analgesics, Opioid; Benzofurans; Codeine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Middle Aged; Morphine; Pain, Postoperative; Pelvis; Placebos; Pyrrolidines; Receptors, Opioid, kappa	1996
Enadoline and butorphanol: evaluation of kappa-agonists on cocaine pharmacodynamics and cocaine self-administration in humans. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1 Topics: Adult; Analgesics, Opioid; Benzofurans; Butorphanol; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Injections, Intramuscular; Male; Neuroprotective Agents; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement, Psychology	2001
Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans. Psychopharmacology, 2001, Volume: 157, Issue:2 Topics: Adult; Analgesics, Opioid; Analysis of Variance; Benzofurans; Butorphanol; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heroin Dependence; Humans; Hydromorphone; Male; Middle Aged; Neuroprotective Agents; Pilot Projects; Pyrrolidines; Receptors, Opioid, kappa	2001

Other Studies

72 other study(ies) available for enadoline and benzofurans

Article	Year
A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro. Neuroscience, 1992, Volume: 47, Issue:1 Topics: Amino Acids; Analgesics; Animals; Benzofurans; Benzomorphans; Bicuculline; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Ligands; Locus Coeruleus; Membrane Potentials; Naloxone; Naltrexone; Picrotoxin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Synapses	1992
Pharmacologic activity of CI-977, a selective kappa opioid agonist, in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3 Topics: Animals; Benzofurans; Cognition; Dose-Response Relationship, Drug; Drug Synergism; Female; Injections, Intramuscular; Macaca mulatta; Male; Morphine; Naloxone; Pain; Pyrrolidines; Receptors, Opioid	1992
The effect of the kappa-opioid receptor agonist CI-977 in a rat model of focal cerebral ischaemia. Brain research, 1992, Mar-27, Volume: 576, Issue:1 Topics: Animals; Benzofurans; Brain Edema; Cerebral Infarction; Disease Models, Animal; Ischemic Attack, Transient; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa	1992
Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro. Brain research, 1992, Jun-26, Volume: 583, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Benzofurans; Bicuculline; Bombesin; Cholecystokinin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Naloxone; Naltrexone; Neurons; Picrotoxin; Prazosin; Pyrrolidines; Quinoxalines; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Synapses; Tetrodotoxin	1992
The anticonvulsant action of CI-977, a selective kappa-opioid receptor agonist: a possible involvement of the glycine/NMDA receptor complex. European journal of pharmacology, 1990, Dec-04, Volume: 191, Issue:3 Topics: Animals; Anticonvulsants; Benzofurans; Dizocilpine Maleate; In Vitro Techniques; Mice; Mice, Inbred Strains; Naltrexone; Piperazines; Pyrrolidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, kappa; Seizures; Stereoisomerism	1990
CI-977, a novel and selective agonist for the kappa-opioid receptor. British journal of pharmacology, 1990, Volume: 101, Issue:1 Topics: Analgesics; Animals; Benzofurans; Binding, Competitive; Brain; Diuretics; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Motor Activity; Muscle, Smooth; Pyrrolidines; Rabbits; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1990
Do related kappa agonists produce similar effects on cardiac ion channels? Proceedings of the Western Pharmacology Society, 1995, Volume: 38 Topics: Animals; Anti-Arrhythmia Agents; Benzofurans; Blood Pressure; Electric Stimulation; Electrocardiography; Heart; Heart Rate; Heart Ventricles; Ion Channels; Male; Myocardium; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereoisomerism; Thiophenes	1995
Pharmacological modification of glutamate neurotoxicity in vivo. Brain research, 1993, Nov-26, Volume: 629, Issue:1 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Benzofurans; Blood Pressure; Brain Ischemia; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Male; Microdialysis; Neurons; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrimidines; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors	1993
Functional implications of kappa opioid receptor-mediated modulation of glutamate transmission in the output regions of the basal ganglia in rodent and primate models of Parkinson's disease. Brain research, 1995, Jun-12, Volume: 683, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Arrhythmia Agents; Basal Ganglia; Benzofurans; Callithrix; Female; Glutamic Acid; In Vitro Techniques; Male; Motor Activity; Naltrexone; Parkinson Disease, Secondary; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reserpine; Synaptic Transmission	1995
Analysis of the antinociceptive actions of the kappa-opioid agonist enadoline (CI-977) in neonatal and adult rats: comparison to kappa-opioid receptor mRNA ontogeny. Drug and alcohol dependence, 1995, Volume: 38, Issue:3 Topics: Age Factors; Analgesics, Opioid; Animals; Animals, Newborn; Arousal; Benzofurans; Dose-Response Relationship, Drug; Gene Expression; Male; Nociceptors; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger	1995
Dual inhibitory action of enadoline (CI977) on release of amino acids in the rat hippocampus. European journal of pharmacology, 1995, Jun-06, Volume: 279, Issue:1 Topics: Amino Acids; Animals; Benzofurans; Chromatography, High Pressure Liquid; Hippocampus; Male; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Veratrine	1995
Agonist and antagonist effects of dynorphin A-(1-13) in a thermal antinociception assay in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1 Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzimidazoles; Benzofurans; Dynorphins; Hot Temperature; Macaca mulatta; Narcotics; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidines; Receptors, Opioid, kappa	1995
Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies. Brain research, 1995, Mar-27, Volume: 675, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzofurans; Brain Ischemia; Cell Death; Cells, Cultured; Dizocilpine Maleate; Hypoxia; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Phencyclidine; Receptors, sigma	1995
Comparative effects of selective kappa-opioid receptor agonists on dopamine levels in the dorsal caudate of freely moving rats. European journal of pharmacology, 1994, Oct-24, Volume: 264, Issue:2 Topics: Analgesics; Animals; Anti-Arrhythmia Agents; Benzofurans; Caudate Nucleus; Chromatography, High Pressure Liquid; Diuretics; Dopamine; Injections, Subcutaneous; Male; Microdialysis; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Structure-Activity Relationship	1994
The neuroprotective kappa-opioid CI-977 alters glutamate-induced calcium signaling in vitro. Neuroreport, 1994, Nov-21, Volume: 5, Issue:17 Topics: Animals; Benzofurans; Calcium; Excitatory Amino Acids; Glutamic Acid; Neurons; Neuroprotective Agents; Osmolar Concentration; Pyrrolidines; Rats; Receptors, Opioid, kappa; Signal Transduction	1994
Behavioral effects of 6-methylene naltrexone (nalmefene) in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3 Topics: Alfentanil; Analgesics; Animals; Behavior, Animal; Benzofurans; Female; Macaca mulatta; Male; Molecular Structure; Nalbuphine; Naltrexone; Narcotic Antagonists; Pyrrolidines	1994
Differential modulation of kappa and mu opioid antinociception by the glycine/NMDA receptor agonist D-serine. British journal of pharmacology, 1994, Volume: 112, Issue:4 Topics: Analgesia; Animals; Benzofurans; Male; Morphine; Pyrrolidines; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serine	1994
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3 Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Saimiri	1994
Distribution of effects of the kappa-opioid agonist CI-977 on cerebral glucose utilization in rat brain. Brain research, 1994, Apr-11, Volume: 642, Issue:1-2 Topics: Animals; Auditory Cortex; Autoradiography; Behavior, Animal; Benzofurans; Brain; Deoxyglucose; Extrapyramidal Tracts; Glucose; Limbic System; Male; Myelin Sheath; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatosensory Cortex; Visual Cortex	1994
Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa	1994
Discriminative stimulus and response rate-decreasing effects of kappa opioids: antagonism by naloxone. Life sciences, 1994, Volume: 54, Issue:23 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzofurans; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Female; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid, kappa	1994
Functional evidence for multiple receptor activation by kappa-ligands in the inhibition of spinal nociceptive reflexes in the rat. British journal of pharmacology, 1993, Volume: 110, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Benzeneacetamides; Benzofurans; Blood Pressure; Decerebrate State; Male; Naloxone; Nociceptors; Piperazines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord; Thiophenes	1993
Anticonvulsant agents, dizocilpine maleate, enadoline and HA 966 have different effects on N-methyl-DL-aspartate-induced immediate early gene induction in mice. Neuroscience, 1993, Volume: 56, Issue:3 Topics: Animals; Anticonvulsants; Benzofurans; Brain; Brain Chemistry; Dizocilpine Maleate; Gene Expression; Genes, Immediate-Early; In Situ Hybridization; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Pyrrolidines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Silver Staining	1993
Neuroprotective effect of the kappa-agonist enadoline (CI-977) in rat models of focal cerebral ischaemia. The European journal of neuroscience, 1993, Jul-01, Volume: 5, Issue:7 Topics: Animals; Benzofurans; Brain; Brain Edema; Brain Ischemia; Cerebral Infarction; Dose-Response Relationship, Drug; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	1993
Effect of the kappa-1 opioid agonist CI-977 on ischemic brain damage and cerebral blood flow after middle cerebral artery occlusion in the rat. Brain research, 1993, Nov-26, Volume: 629, Issue:1 Topics: Animals; Antipyrine; Autoradiography; Benzofurans; Blood Pressure; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Functional Laterality; Iodine Radioisotopes; Male; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors	1993
The effect of dizocilpine and enadoline on immediate early gene expression in the gerbil global ischaemia model. Neuropharmacology, 1993, Volume: 32, Issue:10 Topics: Animals; Autoradiography; Benzofurans; Brain Ischemia; Dizocilpine Maleate; DNA-Binding Proteins; Female; Gene Expression; Genes, Immediate-Early; Gerbillinae; Heat-Shock Proteins; Hippocampus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; RNA, Messenger; Transcription Factors	1993
Electrophysiological and antiarrhythmic actions of the kappa agonist PD 129290, and its R,R (+)-enantiomer, PD 129289. British journal of pharmacology, 1993, Volume: 110, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Benzofurans; Blood Pressure; Electric Stimulation; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Male; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereoisomerism	1993
Brain temperature and the neuroprotective action of enadoline and dizocilpine in the gerbil model of global ischaemia. European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2 Topics: Animals; Benzofurans; Body Temperature; Brain; Dizocilpine Maleate; Female; Gerbillinae; Ischemic Attack, Transient; Models, Biological; Pyrrolidines	1993
Focal cerebral ischemia in the cat: pretreatment with a kappa-1 opioid receptor agonist, CI-977. Brain research, 1993, Aug-06, Volume: 618, Issue:2 Topics: Animals; Benzofurans; Blood Glucose; Blood Pressure; Body Temperature; Brain; Cats; Cerebral Arteries; Hematocrit; Histocytochemistry; Ischemic Attack, Transient; Pyrrolidines; Receptors, Opioid, kappa	1993
Modulation of glutamate release by a kappa-opioid receptor agonist in rodent and primate striatum. European journal of pharmacology, 1995, Jul-25, Volume: 281, Issue:1 Topics: 4-Aminopyridine; Animals; Benzofurans; Callithrix; Corpus Striatum; Glutamic Acid; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Synaptosomes	1995
Discriminative stimulus effects on enadoline in pigeons. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2 Topics: Animals; Benzofurans; Butorphanol; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Dynorphins; Nalbuphine; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa	1996
Differential contribution of descending controls to the antinociceptive actions of kappa and mu opioids: an analysis of formalin-evoked C-fos expression. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2 Topics: Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Formaldehyde; Male; Naloxone; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1996
The relationship between glutamate release and cerebral blood flow after focal cerebral ischaemia in the cat: effect of pretreatment with enadoline (a kappa receptor agonist). Brain research, 1996, Mar-18, Volume: 712, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Benzofurans; Blood Glucose; Body Temperature; Brain Ischemia; Cats; Cerebrovascular Circulation; Female; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; Pyrrolidines; Receptors, Opioid, kappa; Stereotaxic Techniques; Tyrosine	1996
Radioligand-dependent discrepancy in agonist affinities enhanced by mutations in the kappa-opioid receptor. Molecular pharmacology, 1996, Volume: 50, Issue:4 Topics: Animals; Benzofurans; COS Cells; Diprenorphine; Dynorphins; Kinetics; Mutation; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Tritium	1996
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats. Life sciences, 1997, Volume: 60, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1997
Activation of c-fos mRNA in the brain by the kappa-opioid receptor agonist enadoline and the NMDA receptor antagonist dizocilpine. European journal of pharmacology, 1997, Jun-05, Volume: 328, Issue:1 Topics: Analysis of Variance; Animals; Autoradiography; Benzofurans; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; In Situ Hybridization; Injections, Intraperitoneal; Male; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; RNA, Messenger; Thalamic Nuclei	1997
EEG spectral analysis of the neuroprotective kappa opioids enadoline and PD117302. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1 Topics: Animals; Benzofurans; Electroencephalography; Male; Narcotics; Neuroprotective Agents; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Thiophenes	1997
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians. European journal of pharmacology, 1997, Jul-16, Volume: 331, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
Kappa-opioid receptor agonists increase locomotor activity in the monoamine-depleted rat model of parkinsonism. Movement disorders : official journal of the Movement Disorder Society, 1998, Volume: 13, Issue:2 Topics: alpha-Methyltyrosine; Animals; Antiparkinson Agents; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Motor Activity; Parkinson Disease, Secondary; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reserpine	1998
kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2 Topics: Analgesics, Opioid; Animals; Benzofurans; Brain Chemistry; Butorphanol; Dose-Response Relationship, Drug; Hot Temperature; Macaca mulatta; Nalbuphine; Naltrexone; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa	1998
Selective depression of dorsal root-evoked high threshold synaptic excitation by the selective kappa opioid receptor agonist enadoline in the neonatal rat hemisected spinal cord in vitro. Neuropharmacology, 1998, Volume: 37, Issue:6 Topics: Animals; Animals, Newborn; Benzofurans; In Vitro Techniques; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord	1998
The effects of excitotoxicity on the expression of the amyloid precursor protein gene in the brain and its modulation by neuroprotective agents. Journal of neural transmission (Vienna, Austria : 1996), 1998, Volume: 105, Issue:4-5 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; Brain; Dizocilpine Maleate; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Kainic Acid; Male; Neuroprotective Agents; Neurotoxins; Organ Specificity; Pentobarbital; Pentylenetetrazole; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic; Trypsin Inhibitor, Kunitz Soybean	1998
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Sep-15, Volume: 18, Issue:18 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzofurans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oligopeptides; Pain Measurement; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Signal Transduction; Vas Deferens	1998
The kappa opioid receptor is associated with the perception of visceral pain. Gut, 1998, Volume: 43, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdominal Pain; Analgesics, Opioid; Animals; Benzofurans; Humans; Mice; Mice, Knockout; Morphine; Nociceptors; Pyrrolidines; Receptors, Opioid, kappa	1998
The discriminative stimulus properties of U50,488 and morphine are not shared by fedotozine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1998, Volume: 8, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzofurans; Benzyl Compounds; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Stimulus; Male; Morphine; Propylamines; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa	1998
Effects of neonatal naltrindole treatment on antinociceptive and behavioral responses to mu and kappa agonists in rats. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:1 Topics: Alfentanil; Animals; Animals, Newborn; Benzofurans; Male; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Psychomotor Performance; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1999
Effects of enadoline on the development of pentylenetetrazol kindling, learning performance, and hippocampal morphology. Brain research, 1999, Mar-27, Volume: 823, Issue:1-2 Topics: Animals; Benzofurans; Convulsants; Glutamic Acid; Hippocampus; Kindling, Neurologic; Learning; Male; Pentylenetetrazole; Pyrrolidines; Rats; Rats, Wistar; Seizures	1999
Spinal administration of selective opioid antagonists in amphibians: evidence for an opioid unireceptor. Life sciences, 1999, Volume: 64, Issue:10 Topics: Acetic Acid; Analgesics; Animals; Benzofurans; Female; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Pyrrolidines; Rana pipiens; Receptors, Opioid; Time Factors	1999
Indirect dopamine agonists augment the locomotor activating effects of the kappa-opioid receptor agonist U-50,488 in preweanling rats. Developmental psychobiology, 1999, Volume: 34, Issue:3 Topics: Age Factors; Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Benzofurans; Cocaine; Dopamine Agonists; Drug Interactions; Female; Locomotion; Male; Methylphenidate; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereotyped Behavior	1999
Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain, 1999, Volume: 80, Issue:1-2 Topics: Anesthesia Recovery Period; Animals; Benzofurans; Blood Gas Analysis; Disease Models, Animal; Hot Temperature; Hyperalgesia; Male; Morphine; Pain, Postoperative; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Respiratory Mechanics; Skin; Touch	1999
Behavioral evaluation of visceral pain in a rat model of colonic inflammation. Neuroreport, 1999, Apr-06, Volume: 10, Issue:5 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzofurans; Cognition; Colitis; Colon; Discrimination, Psychological; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Viscera	1999
Control of glutamate release by calcium channels and kappa-opioid receptors in rodent and primate striatum. British journal of pharmacology, 1999, Volume: 127, Issue:1 Topics: 4-Aminopyridine; Animals; Benzofurans; Calcium Channel Blockers; Calcium Channels; Callithrix; Glutamic Acid; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neostriatum; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spider Venoms; Synaptosomes; Tetrodotoxin	1999
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine. European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes	1999
The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat. British journal of pharmacology, 1999, Volume: 128, Issue:7 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzofurans; Biogenic Monoamines; Clonidine; Disease Models, Animal; Drug Combinations; Drug Synergism; Locomotion; Male; Naltrexone; Narcotic Antagonists; Parkinson Disease, Secondary; Prazosin; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reserpine; Yohimbine	1999
In vitro agonist effects of nociceptin and [Phe(1)psi(CH(2)-NH)Gly(2)]nociceptin(1-13)NH(2) in the mouse and rat colon and the mouse vas deferens. European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3 Topics: Animals; Benzeneacetamides; Benzofurans; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred DBA; Muscle Contraction; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin; Vas Deferens	1999
Effects of somatostatin, octreotide and cortistatin on ischaemic neuronal damage following permanent middle cerebral artery occlusion in the rat. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:6 Topics: Animals; Benzofurans; Body Temperature; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Hormones; Injections, Intraventricular; Male; Middle Cerebral Artery; Neurons; Neuropeptides; Neuroprotective Agents; Octreotide; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Somatostatin	1999
Unbound plasma concentrations may predict neuroprotective brain concentrations: a brain microdialysis and pharmacokinetic study of enadoline in rats. Acta neurochirurgica. Supplement, 1999, Volume: 75 Topics: Animals; Benzofurans; Binding, Competitive; Brain; Extracellular Space; Microdialysis; Neuroprotective Agents; Plasma; Prospective Studies; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley	1999
Modulation of the discriminative stimulus effects of d-amphetamine by mu and kappa opioids in squirrel monkeys. Pharmacology, biochemistry, and behavior, 2000, Jan-01, Volume: 65, Issue:1 Topics: Animals; Benzeneacetamides; Benzofurans; Cocaine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Morphine; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	2000
Autoradiographic distribution of mu-, delta- and kappa 1-opioid stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in human frontal cortex and cerebellum. Neuroscience letters, 2000, Apr-14, Volume: 283, Issue:3 Topics: Autoradiography; Benzofurans; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Frontal Lobe; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes	2000
Kappa-opioid receptor modulation of nicotine-induced behaviour. Neuropharmacology, 2000, Volume: 39, Issue:13 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats; Receptors, Opioid, kappa	2000
Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats. Psychopharmacology, 2000, Volume: 153, Issue:1 Topics: Alcohol Drinking; Animals; Benzofurans; Conditioning, Operant; Drinking; Eating; Male; Naltrexone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Recurrence; Self Administration	2000
Enadoline discrimination in squirrel monkeys: effects of opioid agonists and antagonists. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1 Topics: Animals; Benzofurans; Discrimination Learning; Dose-Response Relationship, Drug; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Thiophenes	2001
Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene. Brain research, 2001, Jul-06, Volume: 906, Issue:1-2 Topics: Analgesics, Opioid; Animals; Autoradiography; Benzofurans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Deletion; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	2001
Sex and rat strain determine sensitivity to kappa opioid-induced antinociception. Psychopharmacology, 2002, Volume: 160, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Benzomorphans; Female; Male; Nalorphine; Narcotics; Pyrrolidines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sex Characteristics	2002
Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice. Brain research, 2002, Jul-26, Volume: 945, Issue:1 Topics: Animals; Autoradiography; Benzofurans; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Heterozygote; Homozygote; Male; Mice; Mice, Knockout; Oligopeptides; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2002
Long-term effects on brain opioid and opioid receptor like-1 receptors after short periods of maternal separation in rats. Neuroscience letters, 2003, Jul-24, Volume: 345, Issue:3 Topics: Animals; Animals, Newborn; Autoradiography; Benzofurans; Binding Sites; Brain; Cell Count; Female; Male; Maternal Deprivation; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Time Factors; Tritium	2003
Modification of kappa-opioid receptor agonist-induced antinociception by diabetes in the mouse brain and spinal cord. Journal of pharmacological sciences, 2005, Volume: 98, Issue:1 Topics: Analgesics; Animals; Benzofurans; Brain; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Spinal Cord	2005
Downregulation of kappa-opioid receptors in basolateral amygdala and septum of rats withdrawn for 14 days from an escalating dose "binge" cocaine administration paradigm. Synapse (New York, N.Y.), 2007, Volume: 61, Issue:10 Topics: Amygdala; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Benzofurans; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Down-Regulation; Drug Administration Schedule; Male; Neuroprotective Agents; Pyrrolidines; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; Septum of Brain; Tritium	2007
Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2 Topics: Animals; Behavior, Addictive; Benzofurans; Clonidine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Male; Naltrexone; Norepinephrine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Self Administration; Stress, Psychological	2007
Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys. European journal of pharmacology, 2007, Dec-08, Volume: 576, Issue:1-3 Topics: Animals; Benzofurans; Blood Pressure; Cocaine; Cocaine-Related Disorders; Drug Interactions; Ethylketocyclazocine; Heart Rate; Male; Pyrrolidines; Receptors, Opioid, kappa; Saimiri	2007
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. Psychopharmacology, 2010, Volume: 210, Issue:2 Topics: Animals; Benzofurans; Citalopram; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Fluoxetine; Ligands; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Saimiri; Selective Serotonin Reuptake Inhibitors; Self Administration; Serotonin; Serotonin 5-HT1 Receptor Agonists	2010
A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors. Neuropharmacology, 2013, Volume: 73 Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Benzofurans; Diterpenes; Drug Administration Routes; Drug Evaluation, Preclinical; Idazoxan; Male; Mice; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrazoles; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Tritium; TRPV Cation Channels	2013