Compounds > emtricitabine
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emtricitabine and zalcitabine

emtricitabine has been researched along with zalcitabine in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's22 (56.41)18.2507
2000's10 (25.64)29.6817
2010's6 (15.38)24.3611
2020's1 (2.56)2.80

Authors

AuthorsStudies
Amblard, F; Bassit, L; Bondada, L; Coats, SJ; Detorio, M; Grier, J; Hernandez-Santiago, BI; Koontz, D; Mellors, JW; Rapp, KL; Schinazi, RF; Sluis-Cremer, N1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Arumugam, SR; Badri, KR; He, JJ; Visalli, RJ; Zhang, X; Zhao, H; Ziobrowski, H1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Cannon, D; Furman, PA; Lloyd, RM; Mathis, R; McMillan, A; Peck, A; Schinazi, RF; Sommadossi, JP; St Clair, M; Wilson, J1
Peck, A; Schinazi, RF; Sommadossi, JP1
Davis, M; Dornsife, RE; Frick, LW; Furman, PA; Fyfe, JA; Liotta, DC; Nelson, DJ; Paff, M; Wilson, LJ; Wurster, JA1
Boudinot, FD; Ibrahim, SS; Liotta, DC; Manning, C; McClure, HM; Schinazi, RF1
Leibowitch, J; Liotta, DC; Mathez, D; Schinazi, RF1
Condreay, LD; Daluge, SM; Ellis, MN; Furman, PA; Jansen, RW; Johnson, LC; Paff, MT; Painter, GR; Powdrill, TF; Selleseth, DW1
Lacey, SF; Larder, BA1
Bazmi, HZ; Cannon, DL; Chu, CK; Ilksoy, N; Liotta, DC; Lloyd, RM; McMillan, A; Mellors, JW; Nguyen, MH; Schinazi, RF1
Borroto-Esoda, K; Furman, PA; Hopkins, S; Liotta, DC; Martin, JL; Painter, G; Wilson, JE1
Frick, LW; Lambe, CU; Nelson, DJ; St John, L; Taylor, LC1
Aldrich, CE; Averett, DR; Cullen, JM; Fourel, I; Mason, WS; Pugh, J; Saputelli, J; Schaffer, P1
Averett, DR; Miller, WH; Nelson, DJ; Paff, MT; Prus, KL1
Abobo, CV; Boudinot, FD; Liotta, DC; Ni, L; Schinazi, RF1
Frick, LW; Furfine, ES; Furman, PA; Liotta, DC; Nelson, DJ; Painter, GR; St John, L; Taylor, LC1
Averett, DR; Jansen, RW; Johnson, LC1
Aulabaugh, AE; Boone, LR; Boyd, FL; Daluge, SM; Davis, MG; Freeman, GA; Miller, WH; Painter, GR; VanDraanen, NA; Wilson, JE1
Averett, DR; Condreay, JP; Condreay, LD; Jansen, RW; Paff, MT1
Farrant, RD; Frick, LW; Lindon, JC; Sanderson, PN; Shockcor, JP; Sweatman, BC; Wurm, RM1
Lloyd, RM; North, TW; Remington, KM; Schinazi, RF; Smith, RA1
Biron, K; Botteron, C; Cecchi, A; Cullen, JM; Davis, MG; Dunn, SE; Frick, L; Goulding, A; Linsey, D; Linzey, D; Paff, MT; Smith, SL1
Aldrich, CE; Averett, D; Condreay, L; Mason, WS; Moraleda, G; Saputelli, J1
Anderson, KS; Feng, JY; Schinazi, RF; Shi, J1
Chan, HL; Lau, TC; Leung, NW; Sung, JJ; Wong, ML1
Avci, A; Erhardt, A; Häussinger, D; Heintges, T; Lörke, J; Sagir, A1
Almond, MR; Liotta, DC; Mao, S; Painter, GR1
Otto, MJ1
Carruth, LM; Clements, JE; Li, M; Mankowski, JL; Miller, MD; Queen, LA; Shen, A; Siliciano, RF; Tarwater, PM; Zink, MC1
Hurwitz, SJ; Otto, MJ; Schinazi, RF1
Arastèh, K; Beard, A; Cartee, L; Drauz, D; Herzmann, C; Kreckel, P; Murphy, RL; Otto, MJ; Schinazi, RF; Schulbin, H1
Nelson, MR; Waters, L1
Dandekar, S; Sankaran, S; Verhoeven, D1
Abuin, A; Cucoranu, I; Fields, E; Green, E; Hosseini, SH; Hoying, A; Ivey, K; Kohler, JJ; Lavie, A; Lewis, W; Raper, CM; Russ, R; Santoianni, R; Yang, Q; Zhelyabovska, O1
Berrino, L; Scaglione, F1
Amancha, PK; Ansari, AA; Hong, JJ; Rogers, K; Villinger, F1

Reviews

5 review(s) available for emtricitabine and zalcitabine

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
[New approaches in the treatment of hepatitis B].
    Deutsche medizinische Wochenschrift (1946), 2004, May-21, Volume: 129, Issue:21

    Topics: 2-Aminopurine; Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Contraindications; Deoxycytidine; Emtricitabine; Famciclovir; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Organophosphorus Compounds; Polyethylene Glycols; Prodrugs; Prognosis; Recombinant Proteins; Tenofovir; Zalcitabine

2004
Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.
    Current topics in medicinal chemistry, 2004, Volume: 4, Issue:10

    Topics: Adenine; Cytidine Triphosphate; Deoxycytidine; Deoxycytidine Monophosphate; Deoxyribonucleotides; Dioxolanes; DNA, Viral; Emtricitabine; HIV Infections; HIV Reverse Transcriptase; Humans; Kinetics; Molecular Structure; Nucleosides; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Protein Binding; Protein Conformation; Purine Nucleosides; Reverse Transcriptase Inhibitors; Substrate Specificity; Tenofovir; Zalcitabine

2004
New nucleoside reverse transcriptase inhibitors for the treatment of HIV infections.
    Current opinion in pharmacology, 2004, Volume: 4, Issue:5

    Topics: Animals; Anti-HIV Agents; Clinical Trials as Topic; Cytidine Triphosphate; Deoxycytidine; Dideoxynucleosides; Dioxolanes; Emtricitabine; HIV Infections; Humans; Purine Nucleosides; Reverse Transcriptase Inhibitors; Thionucleosides; Zalcitabine

2004
New drugs.
    HIV medicine, 2005, Volume: 6, Issue:4

    Topics: Anti-HIV Agents; Benzophenones; Cytidine Triphosphate; Darunavir; Deoxycytidine; Emtricitabine; HIV; HIV Fusion Inhibitors; HIV Reverse Transcriptase; Humans; Imidazoles; Nitriles; Protease Inhibitors; Pyridazines; Pyridines; Pyrimidines; Pyrones; Reverse Transcriptase Inhibitors; Sulfonamides; Sulfur Compounds; Zalcitabine

2005

Trials

4 trial(s) available for emtricitabine and zalcitabine

ArticleYear
Hplc-nmr identification of the human urinary metabolites of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV).
    Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:2

    Topics: Antiviral Agents; Biotransformation; Chromatography, High Pressure Liquid; Emtricitabine; Glucuronates; HIV; Humans; Magnetic Resonance Spectroscopy; Spectrophotometry, Ultraviolet; Stereoisomerism; Sulfoxides; Zalcitabine

1996
Comparison of three different sensitive assays for hepatitis B virus DNA in monitoring of responses to antiviral therapy.
    Journal of clinical microbiology, 2000, Volume: 38, Issue:9

    Topics: Antiviral Agents; DNA, Viral; Emtricitabine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Nucleic Acid Hybridization; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Zalcitabine

2000
Comparative pharmacokinetics of Racivir, (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats, rabbits, dogs, monkeys and HIV-infected humans.
    Antiviral chemistry & chemotherapy, 2005, Volume: 16, Issue:2

    Topics: Animals; Antiviral Agents; Dogs; Emtricitabine; Female; HIV Infections; Humans; Macaca mulatta; Male; Pregnancy; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Zalcitabine

2005
Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:7

    Topics: Administration, Oral; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Middle Aged; Oxazines; Plasma; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Urine; Zalcitabine

2005

Other Studies

30 other study(ies) available for emtricitabine and zalcitabine

ArticleYear
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Anti-HIV Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Molecular Structure; Reverse Transcriptase Inhibitors

2009
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase.
    Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16

    Topics: Acyclovir; Animals; Antiviral Agents; Betulinic Acid; Chlorocebus aethiops; Herpesvirus 2, Human; HIV Reverse Transcriptase; HIV-1; Humans; Pentacyclic Triterpenes; Triterpenes; Vero Cells; Virus Replication

2015
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11

    Topics: Antiviral Agents; Emtricitabine; HIV; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Stereoisomerism; Zalcitabine; Zidovudine

1992
Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity.
    Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2

    Topics: Antiviral Agents; Biological Availability; Deoxyuridine; Dideoxynucleosides; Emtricitabine; Escherichia coli; HIV; Pyrimidine Nucleosides; Stavudine; Substrate Specificity; Thymidine Phosphorylase; Zalcitabine

1992
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:12

    Topics: Animals; Antiviral Agents; Cell Survival; Cytidine Deaminase; DNA, Viral; Emtricitabine; Growth Inhibitors; Hepatitis B virus; Humans; Macaca fascicularis; Phosphorylation; Stereoisomerism; Substrate Specificity; Zalcitabine

1992
Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11

    Topics: Administration, Oral; Animals; Antiviral Agents; Body Weight; Emtricitabine; Injections, Intravenous; Macaca mulatta; Male; Stereoisomerism; Tissue Distribution; Zalcitabine

1992
Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cells, Cultured; Dideoxynucleosides; Drug Interactions; Emtricitabine; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Lymphocyte Activation; Lymphocytes; Models, Biological; Reproducibility of Results; Reverse Transcriptase Inhibitors; Virus Replication; Zalcitabine; Zidovudine

1993
Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:3

    Topics: alpha-Fetoproteins; Animals; Antiviral Agents; Biological Availability; Cell Line; DNA, Viral; Emtricitabine; Hepatitis B; Hepatitis B virus; Humans; Mice; Polymerase Chain Reaction; Virus Replication; Zalcitabine

1994
Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2',3'-didehydro-2',3'-dideoxythymidine in cell culture.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:6

    Topics: Base Sequence; Cells, Cultured; Drug Resistance, Microbial; Emtricitabine; HeLa Cells; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Stavudine; Zalcitabine; Zidovudine

1994
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:4

    Topics: Antiviral Agents; Base Sequence; Cell Line; Cloning, Molecular; Dideoxynucleosides; Drug Resistance, Microbial; Emtricitabine; Gene Amplification; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Molecular Sequence Data; Moloney murine leukemia virus; Monocytes; Point Mutation; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Virus Replication; Zalcitabine

1993
The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:8

    Topics: Antiviral Agents; Cytidine Triphosphate; DNA, Viral; Emtricitabine; HIV Reverse Transcriptase; HIV-1; Kinetics; Reverse Transcriptase Inhibitors; RNA, Viral; Stereoisomerism; Thiophenes; Zalcitabine

1993
Pharmacokinetics, oral bioavailability, and metabolism in mice and cynomolgus monkeys of (2'R,5'S-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, an agent active against human immunodeficiency virus and human hepatitis B virus.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:12

    Topics: Administration, Oral; Animals; Antiviral Agents; Biological Availability; Emtricitabine; Hepatitis B virus; HIV; Macaca fascicularis; Male; Mice; Mice, Inbred ICR; Species Specificity; Zalcitabine

1994
Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks.
    Journal of virology, 1994, Volume: 68, Issue:12

    Topics: Animals; Antigens, Viral; Antiviral Agents; Biopsy; Bromodeoxyuridine; Deoxyguanosine; DNA Replication; DNA, Viral; Ducks; Emtricitabine; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Kinetics; Liver; Time Factors; Virus Replication; Zalcitabine

1994
Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:6

    Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Emtricitabine; Half-Life; Humans; Liver; Stereoisomerism; Zalcitabine

1994
Pharmacokinetics of 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats.
    Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:1

    Topics: Animals; Antiviral Agents; Dose-Response Relationship, Drug; Emtricitabine; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Zalcitabine

1994
Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:11

    Topics: Administration, Oral; Animals; Antiviral Agents; Biological Availability; Biotransformation; Brain; Chromatography, High Pressure Liquid; Emtricitabine; Half-Life; Hepatitis B virus; HIV-1; Humans; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Tissue Distribution; Zalcitabine

1993
High-capacity in vitro assessment of anti-hepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:3

    Topics: Antibody Specificity; Antiviral Agents; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Emtricitabine; Growth Inhibitors; Hepatitis B virus; Humans; Liver Neoplasms; Molecular Sequence Data; Polymerase Chain Reaction; Virion; Zalcitabine

1993
DNA polymerase activity of hepatitis B virus particles: differential inhibition by L-enantiomers of nucleotide analogs.
    Antiviral research, 1996, Volume: 30, Issue:2-3

    Topics: Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA-Directed DNA Polymerase; DNA, Viral; Emtricitabine; Hepatitis B virus; Humans; Isotope Labeling; Nucleic Acid Synthesis Inhibitors; Nucleotides; Templates, Genetic; Thymine Nucleotides; Zalcitabine

1996
(-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:2

    Topics: Antiviral Agents; Blotting, Southern; Cells, Cultured; Emtricitabine; Hepatitis B virus; Humans; Liver; Time Factors; Virus Replication; Zalcitabine

1996
A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides.
    Journal of virology, 1997, Volume: 71, Issue:3

    Topics: Animals; Antiviral Agents; Binding Sites; Cats; Cell Line; Drug Resistance, Microbial; Emtricitabine; Immunodeficiency Virus, Feline; Lamivudine; Methionine; Mutagenesis, Site-Directed; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Threonine; Viral Plaque Assay; Zalcitabine

1997
In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:10

    Topics: Animals; Antiviral Agents; DNA, Viral; Emtricitabine; Half-Life; Hepatitis B; Hepatitis B Virus, Woodchuck; Liver; Marmota; Stereoisomerism; Zalcitabine

1997
Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus.
    Journal of virology, 1997, Volume: 71, Issue:12

    Topics: Animals; Antiviral Agents; Cells, Cultured; DNA, Circular; DNA, Viral; Emtricitabine; Hepatitis B Virus, Woodchuck; Lamivudine; Liver; Marmota; Rats; Reverse Transcriptase Inhibitors; Virus Replication; Zalcitabine

1997
Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:12

    Topics: Base Sequence; Emtricitabine; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Lamivudine; Molecular Sequence Data; Oligodeoxyribonucleotides; Reverse Transcriptase Inhibitors; Substrate Specificity; Virus Replication; Zalcitabine

1999
SIV-specific T lymphocyte responses in PBMC and lymphoid tissues of SIV-infected pigtailed macaques during suppressive combination antiretroviral therapy.
    Journal of medical primatology, 2005, Volume: 34, Issue:3

    Topics: Adenine; Animals; Anti-Retroviral Agents; Drug Therapy, Combination; Emtricitabine; Immunity, Cellular; Interferon-gamma; Linear Models; Macaca nemestrina; Organophosphonates; Primate Diseases; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Viremia; Zalcitabine

2005
Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy.
    Journal of medical primatology, 2007, Volume: 36, Issue:4-5

    Topics: Adenine; Animals; Anti-Retroviral Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; DNA, Viral; Emtricitabine; Flow Cytometry; Immunologic Memory; Lymphoid Tissue; Macaca mulatta; Organophosphonates; Polymerase Chain Reaction; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocyte Subsets; Tenofovir; Viral Load; Virus Replication; Zalcitabine

2007
Transgenic cardiac-targeted overexpression of human thymidylate kinase.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:3

    Topics: Animals; Anti-HIV Agents; DNA Replication; DNA, Mitochondrial; Echocardiography; Emtricitabine; Female; Humans; Hypertrophy, Left Ventricular; Male; Mice; Mice, Transgenic; Mitochondria, Heart; Myocardium; Nucleoside-Phosphate Kinase; Nucleosides; Phosphorylation; Ventricular Function, Left; Zalcitabine; Zidovudine

2010
Cytosine deoxyribonucleoside anti-HIV analogues: a small chemical substitution allows relevant activities.
    International journal of antimicrobial agents, 2012, Volume: 39, Issue:6

    Topics: Anti-HIV Agents; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; HIV Infections; HIV-1; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Treatment Outcome; Zalcitabine

2012
In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Dec-15, Volume: 191, Issue:12

    Topics: Adenine; Animals; Anti-Retroviral Agents; Antibodies, Monoclonal; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Combined Modality Therapy; Drug Evaluation, Preclinical; Emtricitabine; Histocompatibility Antigens Class I; Immunity, Cellular; Immunoglobulin Fc Fragments; Immunotherapy; Lymphokines; Macaca mulatta; Organophosphonates; Programmed Cell Death 1 Receptor; Recombinant Proteins; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Solubility; Tenofovir; Viremia; Zalcitabine

2013