emtricitabine--tenofovir-disoproxil-fumarate-drug-combination and dolutegravir

Toxoplasmosis is an important cause of enhancing brain lesions in patients with acquired immunodeficiency syndrome (AIDS), and it is typically associated with low CD4-lymphocyte counts. Extensive toxoplasma encephalitis when the CD4-lymphocyte count is above 100 cells/µl is unusual. Cavitary lung lesions are also not typically associated with toxoplasmosis. Here, we present a case of toxoplasmosis associated with extensive brain masses and cavitary lung lesions, both of which improved with directed toxoplasmosis therapy, in an AIDS patient with a CD4 cell count of 120 cells/µl.

Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antibodies, Protozoan; Antiprotozoal Agents; Brain; CD4 Lymphocyte Count; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Heterocyclic Compounds, 3-Ring; Humans; Leucovorin; Magnetic Resonance Imaging; Male; Middle Aged; Oxazines; Piperazines; Polymerase Chain Reaction; Pyridones; Toxoplasma; Toxoplasmosis, Cerebral; Treatment Outcome