Compounds > emodin

emodin and paclitaxel

emodin has been researched along with paclitaxel in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's4 (30.77)29.6817
2010's5 (38.46)24.3611
2020's3 (23.08)2.80

Authors

AuthorsStudies
Fang, X; Shao, L; Wang, S; Zhang, H1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Bai, Z; Shao, J; Wang, C; Wang, W; Yuan, Y; Zhang, F1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Fan, L; Hao, X; Hu, X; Shao, J; Wang, J; Wang, W; Yuan, Y; Zhao, W; Zheng, Y; Zhu, L; Zhu, Y1
Hortobagyi, GN; Hung, MC; Lau, YK; Xia, W; Zhang, L1
Li, J; Liu, P; Mao, H; Wanga, A; Zhang, X1
Guo, H; Sun, D; Xiang, Z; Zhang, Y1
Chen, S; Zhang, J; Zhang, Z1
He, X; Hu, B; Lin, H; Mao, J; Peng, Y; Wang, J; Wang, Y; Zhang, F; Zhang, T; Zheng, J1
Cui, W; He, Y; Li, X; Wei, L; Zhang, J; Zhang, S1
Liu, XX; Tan, S; Tang, L; Yang, XD; Zou, ZW1

Other Studies

13 other study(ies) available for emodin and paclitaxel

ArticleYear
CHMIS-C: a comprehensive herbal medicine information system for cancer.
    Journal of medicinal chemistry, 2005, Mar-10, Volume: 48, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Databases, Factual; Internet; National Institutes of Health (U.S.); Neoplasms; Phytotherapy; Plant Preparations; United States; United States Food and Drug Administration

2005
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Synthesis and antitumor activity of emodin quaternary ammonium salt derivatives.
    European journal of medicinal chemistry, 2012, Volume: 56

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Emodin; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; Mice; Mice, Inbred Strains; Molecular Structure; Quaternary Ammonium Compounds; Salts; Structure-Activity Relationship; Tumor Cells, Cultured

2012
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Synthesis, SAR and pharmacological characterization of novel anthraquinone cation compounds as potential anticancer agents.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Anthraquinones; Antineoplastic Agents; Apoptosis; Cations; Cell Line, Tumor; Emodin; Humans; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Structure-Activity Relationship

2017
Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Division; Disease Models, Animal; Drug Synergism; Emodin; Enzyme Inhibitors; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine

1999
Emodin sensitizes paclitaxel-resistant human ovarian cancer cells to paclitaxel-induced apoptosis in vitro.
    Oncology reports, 2009, Volume: 21, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Emodin; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Ovarian Neoplasms; Paclitaxel; RNA, Messenger; Survivin; X-Linked Inhibitor of Apoptosis Protein

2009
Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2019, Volume: 21, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Chemotherapy, Adjuvant; Emodin; Female; Gene Expression; Humans; Mice, SCID; Paclitaxel; Phosphogluconate Dehydrogenase; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; Tumor Cells, Cultured; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2019
Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Emodin; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Paclitaxel; Structure-Activity Relationship; Tumor Cells, Cultured

2019
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
    Biochemical pharmacology, 2020, Volume: 171

    Topics: A549 Cells; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Movement; Cell Survival; Cytochrome P-450 CYP1B1; Drug Resistance, Neoplasm; Emodin; Humans; Lung Neoplasms; MAP Kinase Signaling System; Molecular Docking Simulation; Molecular Structure; Paclitaxel; Proteins; Proto-Oncogene Proteins c-akt

2020
Physcion-8-O-β-d-glucoside interferes with the nuclear factor-κB pathway and downregulates P-glycoprotein expression to reduce paclitaxel resistance in ovarian cancer cells.
    The Journal of pharmacy and pharmacology, 2021, Mar-08, Volume: 73, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Emodin; Female; Glucosides; Humans; Ovarian Neoplasms; Paclitaxel; Transcription Factor RelA; Xenograft Model Antitumor Assays

2021
A compound formulation of EGF-modified paclitaxel micelles and EGF-modified emodin micelles enhance the therapeutic effect of ovarian cancer.
    Journal of liposome research, 2023, Volume: 33, Issue:1

    Topics: Cell Line, Tumor; Emodin; Epidermal Growth Factor; Female; Humans; Liposomes; Micelles; Ovarian Neoplasms; Paclitaxel

2023