emivirine and uracil
emivirine has been researched along with uracil in 37 studies
Research
Studies (37)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (29.73) | 18.2507 |
| 2000's | 21 (56.76) | 29.6817 |
| 2010's | 5 (13.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Baba, M; De Clercq, E; Miyasaka, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT; Yuasa, S | 1 |
| Brennan, TM; Bridges, CG; Leyda, JP; Taylor, DL; Tyms, AS | 1 |
| Baba, M; Inouye, N; Sadakata, Y; Sekiya, K; Takashima, H; Ubasawa, M; Yuasa, S | 1 |
| Baba, M; Makino, M; Nakade, K; Okamoto, M; Yamada, K; Yuasa, S | 1 |
| Balzarini, J; De ClercQ, E; Karlsson, A; Kleim, JP; Pelemans, H | 1 |
| Baba, M; Nakade, K; Piras, G; Yuasa, S | 1 |
| Danel, K; Nielsen, C; Pedersen, EB | 1 |
| Baba, M; Fujimoto, K; Hayashi, M; Hopkins, AL; Jones, EY; Miyasaka, T; Ren, J; Stammers, DK; Stuart, DI; Tanaka, H; Walker, RT | 1 |
| Griffith, R; Keller, PA; Titmuss, SJ | 1 |
| Crowe, S | 1 |
| Baba, M; Hopkins, AL; Okamato, M; Ren, J; Stammers, DK; Stuart, DI; Tanaka, H | 1 |
| Barry, DW; Blum, MR; Borroto-Esoda, K; Endoh, R; Furman, P; Grizzle, TB; Moxham, C; Niwa, T; Painter, GR; Sommadossi, J; Szczech, GM; Yamamoto, M | 1 |
| Duval, X | 1 |
| Balzarini, J; Burt, V; Carbonez, A; De Clercq, E; Kleim, JP | 1 |
| Jorgensen, WL; Rizzo, RC; Tirado-Rives, J | 1 |
| Jorgensen, WL; Kroeger Smith, MB; Rizzo, RC; Smith, RH; Tirado-Rives, J; Udier-Blagović, M; Wang, DP; Watkins, EK | 1 |
| Boel, AM; Dahan, B; El-Brollosy, NR; Jørgensen, PT; Nielsen, C; Pedersen, EB | 1 |
| El-Brollosy, NR; Nielsen, C; Pedersen, EB | 1 |
| Baba, M; Nitanda, T; Somekawa, K; Wang, X; Yuasa, S | 1 |
| Hansen, AL; Nielsen, C; Pedersen, EB; Therkelsen, FD | 1 |
| Jessen, CH; Nielsen, C; Pedersen, EB; Petersen, L | 1 |
| El-Brollosy, NR; Nielsen, C; Pedersen, EB; Wamberg, M | 1 |
| Nielsen, C; Pedersen, EB; Wamberg, M | 1 |
| Andries, K; Benjahad, A; Bisagni, E; Coupa, S; Courté, K; Csoka, I; de Béthune, MP; Grierson, DS; Guillemont, J; Mabire, D; Monneret, C; Nguyen, CH; Pauwels, R; Poncelet, A | 1 |
| Hansen, TH; Jørgensen, PT; Nielsen, C; Nielsen, J; Pedersen, EB; Petersen, L | 1 |
| Boudet, N; Knochel, P | 1 |
| Guo, Y; Liu, J; Lou, Q; Wang, X; Xu, Y; Zhang, Z | 1 |
| Aly, YL; La Colla, P; Loddo, R; Pedersen, EB | 1 |
| Danel, K; La Colla, P; Larsen, LM; Loddo, R; Pedersen, EB; Sanna, G | 1 |
| El-Brollosy, NR; La Colla, P; Loddo, R; Pedersen, EB; Sanna, G; Sørensen, ER | 1 |
| La Colla, P; Loddo, R; Loksha, YM; Pedersen, EB | 1 |
| Al-Deeb, OA; Collu, G; El-Brollosy, NR; El-Emam, AA; La Colla, P; Loddo, R; Pedersen, EB; Sanna, G | 1 |
| Decha, P; Hannongbua, S; Intharathep, P; Parasuk, V; Sompornpisut, P; Udommaneethanakit, T; Wolschann, P | 1 |
| Hattori, T; Kodama, EN; Li, S | 1 |
| Collu, G; Giliberti, G; La Colla, P; Loddo, R; Loksha, YM; Pedersen, EB; Sanna, G | 1 |
| El-Brollosy, NR; Loddo, R | 1 |
| Abrams, E; Akpomiemie, G; Arulappan, N; Chandiwana, N; Chersich, M; Clayden, P; Fairlie, L; Hill, A; Masenya, M; Mashabane, N; McCann, K; Moorhouse, M; Norris, S; Qavi, A; Serenata, C; Simmons, B; Sokhela, S; Venter, WDF; Vos, A | 1 |
Reviews
1 review(s) available for emivirine and uracil
| Article | Year |
|---|---|
New reverse transcriptase inhibitors.
Topics: Adenine; Alkynes; Benzoxazines; Cyclopropanes; Delavirdine; Dideoxynucleosides; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Organophosphonates; Oxazines; Prodrugs; Reverse Transcriptase Inhibitors; Soman; Uracil | 1999 |
Trials
1 trial(s) available for emivirine and uracil
| Article | Year |
|---|---|
Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV.
Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Bone Density; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; Intention to Treat Analysis; Male; Middle Aged; Oxazines; Phosphorous Acids; Piperazines; Pregnancy; Pregnancy Complications, Infectious; Prodrugs; Pyridones; RNA, Viral; Uracil; Viral Load; Young Adult | 2019 |
Other Studies
35 other study(ies) available for emivirine and uracil
| Article | Year |
|---|---|
Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro.
Topics: Antiviral Agents; Cells, Cultured; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Drug Synergism; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Reverse Transcriptase Inhibitors; Uracil; Virus Replication; Zidovudine | 1994 |
The inhibition of human immunodeficiency virus type 1 in vitro by a non-nucleoside reverse transcriptase inhibitor MKC-442, alone and in combination with other anti-HIV compounds.
Topics: Antiviral Agents; Cells, Cultured; Cytotoxicity Tests, Immunologic; Didanosine; Drug Interactions; HIV Reverse Transcriptase; HIV-1; Humans; Indolizines; Isoquinolines; Leukocytes, Mononuclear; Molecular Structure; Nevirapine; Pyridines; Quinolines; Reverse Transcriptase Inhibitors; Saquinavir; Uracil; Zalcitabine; Zidovudine | 1995 |
Selective and synergistic inhibition of human immunodeficiency virus type 1 reverse transcriptase by a non-nucleoside inhibitor, MKC-442.
Topics: Antiviral Agents; Dideoxynucleotides; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Kinetics; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Uracil; Virus Replication; Zidovudine | 1993 |
Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells.
Topics: Acetamides; Acetophenones; Cell Line, Transformed; HIV; HIV Core Protein p24; HIV-1; Humans; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Uracil; Zidovudine | 1996 |
Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors.
Topics: Base Sequence; Cell Line; DNA Primers; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Point Mutation; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Uracil; Virus Replication | 1996 |
Three-drug combination of MKC-442, lamivudine and zidovudine in vitro: potential approach towards effective chemotherapy against HIV-1.
Topics: Anti-HIV Agents; Cell Line, Transformed; Cells, Cultured; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Uracil; Zidovudine | 1997 |
Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones.
Topics: Alkylation; Anti-HIV Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Magnetic Resonance Spectroscopy; Mesylates; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thiazoles; Thymine; Uracil; Virus Replication | 1998 |
Allosteric inhibitors against HIV-1 reverse transcriptase: design and synthesis of MKC-442 analogues having an omega-functionalized acyclic structure.
Topics: Allosteric Site; Anti-HIV Agents; Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Hydrogen Bonding; Mass Spectrometry; Models, Molecular; Molecular Structure; Reverse Transcriptase Inhibitors; Uracil; Virus Replication | 1998 |
Docking experiments in the flexible non-nucleoside inhibitor binding pocket of HIV-1 reverse transcriptase.
Topics: Binding Sites; Databases, Factual; HIV; HIV Reverse Transcriptase; Ligands; Molecular Structure; Nevirapine; Protein Conformation; Reproducibility of Results; Reverse Transcriptase Inhibitors; Uracil | 1999 |
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
Topics: Animals; Anti-HIV Agents; Cell Line; Crystallography, X-Ray; Drug Design; Drug Resistance, Microbial; HIV-1; Models, Molecular; Molecular Conformation; Mutation; Reverse Transcriptase Inhibitors; Uracil | 1999 |
Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.
Topics: Animals; Anti-HIV Agents; Bone Marrow; Dogs; Female; Fetus; Guinea Pigs; HIV-1; Humans; Liver; Macaca fascicularis; Male; Mice; Pregnancy; Rabbits; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Uracil | 2000 |
[The 39th ICAAC (San Francisco) and the 7th European Conference on Clinical Aspects and Treatment of HIV-infection (Lisbon). HIV infection: antiretroviral agents in the development and trial stage].
Topics: Alkynes; Animals; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Oxazines; Quinoxalines; Reverse Transcriptase Inhibitors; Time Factors; Uracil; Viral Load | 2000 |
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.
Topics: Alkynes; Anilides; Anti-HIV Agents; Benzoxazines; Cell Line; Cyclopropanes; Delavirdine; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Microbial; Furans; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Mutation; Nevirapine; Oxazines; Quinoxalines; Reverse Transcriptase Inhibitors; Thioamides; Uracil | 2000 |
Estimation of binding affinities for HEPT and nevirapine analogues with HIV-1 reverse transcriptase via Monte Carlo simulations.
Topics: Anti-HIV Agents; HIV Reverse Transcriptase; Models, Molecular; Monte Carlo Method; Nevirapine; Protein Binding; Pyrimidinones; Regression Analysis; Reverse Transcriptase Inhibitors; Thermodynamics; Uracil | 2001 |
Prediction of activity for nonnucleoside inhibitors with HIV-1 reverse transcriptase based on Monte Carlo simulations.
Topics: Alkynes; Anilides; Benzoxazines; Computer Simulation; Cyclopropanes; HIV Reverse Transcriptase; Hydrogen Bonding; Models, Molecular; Monte Carlo Method; Nevirapine; Oxazines; Protein Binding; Quinoxalines; Regression Analysis; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil | 2002 |
Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants.
Topics: Anti-HIV Agents; Cell Line; HIV-1; Humans; Magnetic Resonance Spectroscopy; Mutation; Stereoisomerism; Structure-Activity Relationship; Uracil; Virus Replication | 2002 |
Synthesis of novel MKC-442 analogues with potent activities against HIV-1.
Topics: Anti-HIV Agents; Cell Line; HIV-1; Humans; Structure-Activity Relationship; Uracil; Virus Replication | 2003 |
Three-drug combinations of emivirine and nucleoside reverse transcriptase inhibitors in vitro: long-term culture of HIV-1-infected cells and breakthrough viruses.
Topics: Anti-HIV Agents; Cell Line; Didanosine; Drug Combinations; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Nucleosides; Reverse Transcriptase Inhibitors; Stavudine; Uracil; Virus Replication | 2001 |
Multiple pathways in the synthesis of new annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (emivirine).
Topics: Anti-HIV Agents; Cell Line, Transformed; Cyclization; HIV-1; Humans; Molecular Conformation; Structure-Activity Relationship; Uracil | 2003 |
Synthesis and evaluation of new potential HIV-1 non-nucleoside reverse transcriptase inhibitors. New analogues of MKC-442 containing Michael acceptors in the C-6 position.
Topics: Anti-HIV Agents; Cell Line; Drug Evaluation, Preclinical; HIV Reverse Transcriptase; HIV-1; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Uracil | 2003 |
Synthesis of 6-arylvinyl analogues of the HIV drugs SJ-3366 and Emivirine.
Topics: Anti-HIV Agents; Cell Line, Transformed; HIV-1; Humans; Inhibitory Concentration 50; Mutation, Missense; Pyrimidinones; Structure-Activity Relationship; Uracil; Virus Replication | 2004 |
Synthesis of furoannelated analogues of Emivirine (MKC-442).
Topics: Cell Line; HIV-1; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil | 2004 |
4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.
Topics: Alkynes; Aminopyridines; Anti-HIV Agents; Benzene Derivatives; Benzoates; Benzoxazines; Cell Line; Cyclopropanes; HIV-1; Humans; Mutagenesis, Site-Directed; Mutation; Nevirapine; Oxazines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil | 2004 |
Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach.
Topics: Cell Line; Drug Resistance, Viral; HIV-1; HIV-2; Humans; Mutation; Prodrugs; Reverse Transcriptase Inhibitors; Stavudine; Stereoisomerism; Structure-Activity Relationship; Sulfides; Thymidine Monophosphate; Uracil | 2005 |
Chemo- and regioselective functionalization of uracil derivatives. Applications to the synthesis of oxypurinol and emivirine.
Topics: Catalysis; Combinatorial Chemistry Techniques; Indicators and Reagents; Molecular Structure; Oxypurinol; Uracil | 2006 |
The design and synthesis of 9-phenylcyclohepta[d]pyrimidine-2,4-dione derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase.
Topics: Anti-HIV Agents; Binding Sites; Crystallography, X-Ray; Cycloheptanes; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; Uracil | 2006 |
Synthesis and anti-HIV-1 activity of new MKC-442 analogues with an alkynyl-substituted 6-benzyl group.
Topics: Anti-HIV Agents; Cell Line; Cell Survival; HIV-1; Humans; Mutation; Structure-Activity Relationship; Uracil; Virus Replication | 2007 |
Synthesis and antiviral activity of new dimeric inhibitors against HIV-1.
Topics: Anti-HIV Agents; Dimerization; HIV-1; Humans; Mutation; Pyrimidines; Uracil; Zidovudine | 2008 |
Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186.
Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil | 2008 |
Synthesis and anti-HIV-1 activity of 1-substiuted 6-(3-cyanobenzoyl) and [(3-cyanophenyl)fluoromethyl]-5-ethyl-uracils.
Topics: Anti-HIV Agents; Cell Line; Cell Survival; Diethylamines; Drug Evaluation, Preclinical; Drug Resistance, Viral; Fluorine; HIV Reverse Transcriptase; HIV-1; Molecular Structure; Mutation; Reverse Transcriptase Inhibitors; Uracil | 2009 |
Synthesis of novel uracil non-nucleoside derivatives as potential reverse transcriptase inhibitors of HIV-1.
Topics: Anti-HIV Agents; HIV-1; Reverse Transcriptase Inhibitors; Uracil | 2009 |
Theoretical studies on the molecular basis of HIV-1RT/NNRTIs interactions.
Topics: Alkynes; Amino Acids; Benzoxazines; Binding Sites; Cyclopropanes; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Models, Biological; Molecular Dynamics Simulation; Mutation; Nevirapine; Nitriles; Protein Binding; Protein Conformation; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Thermodynamics; Uracil; Water | 2011 |
Epigallocatechin gallate inhibits the HIV reverse transcription step.
Topics: Anti-HIV Agents; Catechin; Drug Evaluation, Preclinical; Drug Synergism; HeLa Cells; HIV Infections; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Reverse Transcriptase Inhibitors; Reverse Transcription; Uracil; Zidovudine | 2011 |
Synthesis of novel fluoro analogues of MKC442 as microbicides.
Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Pyrimidinones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil | 2014 |
Synthesis and Antiviral Evaluation of 1-[(2-Phenoxyethyl)oxymethyl] and 6-(3,5-Dimethoxybenzyl) Analogues of HIV Drugs Emivirine and TNK-651.
Topics: Anti-HIV Agents; Cell Line; HIV-1; Microbial Sensitivity Tests; Molecular Structure; Mutation; Pyrimidines; Structure-Activity Relationship; Uracil | 2016 |