Compounds > emivirine
Page last updated: 2024-08-24

emivirine and uracil

emivirine has been researched along with uracil in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (29.73)18.2507
2000's21 (56.76)29.6817
2010's5 (13.51)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baba, M; De Clercq, E; Miyasaka, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT; Yuasa, S1
Brennan, TM; Bridges, CG; Leyda, JP; Taylor, DL; Tyms, AS1
Baba, M; Inouye, N; Sadakata, Y; Sekiya, K; Takashima, H; Ubasawa, M; Yuasa, S1
Baba, M; Makino, M; Nakade, K; Okamoto, M; Yamada, K; Yuasa, S1
Balzarini, J; De ClercQ, E; Karlsson, A; Kleim, JP; Pelemans, H1
Baba, M; Nakade, K; Piras, G; Yuasa, S1
Danel, K; Nielsen, C; Pedersen, EB1
Baba, M; Fujimoto, K; Hayashi, M; Hopkins, AL; Jones, EY; Miyasaka, T; Ren, J; Stammers, DK; Stuart, DI; Tanaka, H; Walker, RT1
Griffith, R; Keller, PA; Titmuss, SJ1
Crowe, S1
Baba, M; Hopkins, AL; Okamato, M; Ren, J; Stammers, DK; Stuart, DI; Tanaka, H1
Barry, DW; Blum, MR; Borroto-Esoda, K; Endoh, R; Furman, P; Grizzle, TB; Moxham, C; Niwa, T; Painter, GR; Sommadossi, J; Szczech, GM; Yamamoto, M1
Duval, X1
Balzarini, J; Burt, V; Carbonez, A; De Clercq, E; Kleim, JP1
Jorgensen, WL; Rizzo, RC; Tirado-Rives, J1
Jorgensen, WL; Kroeger Smith, MB; Rizzo, RC; Smith, RH; Tirado-Rives, J; Udier-Blagović, M; Wang, DP; Watkins, EK1
Boel, AM; Dahan, B; El-Brollosy, NR; Jørgensen, PT; Nielsen, C; Pedersen, EB1
El-Brollosy, NR; Nielsen, C; Pedersen, EB1
Baba, M; Nitanda, T; Somekawa, K; Wang, X; Yuasa, S1
Hansen, AL; Nielsen, C; Pedersen, EB; Therkelsen, FD1
Jessen, CH; Nielsen, C; Pedersen, EB; Petersen, L1
El-Brollosy, NR; Nielsen, C; Pedersen, EB; Wamberg, M1
Nielsen, C; Pedersen, EB; Wamberg, M1
Andries, K; Benjahad, A; Bisagni, E; Coupa, S; Courté, K; Csoka, I; de Béthune, MP; Grierson, DS; Guillemont, J; Mabire, D; Monneret, C; Nguyen, CH; Pauwels, R; Poncelet, A1
Hansen, TH; Jørgensen, PT; Nielsen, C; Nielsen, J; Pedersen, EB; Petersen, L1
Boudet, N; Knochel, P1
Guo, Y; Liu, J; Lou, Q; Wang, X; Xu, Y; Zhang, Z1
Aly, YL; La Colla, P; Loddo, R; Pedersen, EB1
Danel, K; La Colla, P; Larsen, LM; Loddo, R; Pedersen, EB; Sanna, G1
El-Brollosy, NR; La Colla, P; Loddo, R; Pedersen, EB; Sanna, G; Sørensen, ER1
La Colla, P; Loddo, R; Loksha, YM; Pedersen, EB1
Al-Deeb, OA; Collu, G; El-Brollosy, NR; El-Emam, AA; La Colla, P; Loddo, R; Pedersen, EB; Sanna, G1
Decha, P; Hannongbua, S; Intharathep, P; Parasuk, V; Sompornpisut, P; Udommaneethanakit, T; Wolschann, P1
Hattori, T; Kodama, EN; Li, S1
Collu, G; Giliberti, G; La Colla, P; Loddo, R; Loksha, YM; Pedersen, EB; Sanna, G1
El-Brollosy, NR; Loddo, R1
Abrams, E; Akpomiemie, G; Arulappan, N; Chandiwana, N; Chersich, M; Clayden, P; Fairlie, L; Hill, A; Masenya, M; Mashabane, N; McCann, K; Moorhouse, M; Norris, S; Qavi, A; Serenata, C; Simmons, B; Sokhela, S; Venter, WDF; Vos, A1

Reviews

1 review(s) available for emivirine and uracil

ArticleYear
New reverse transcriptase inhibitors.
    Advances in experimental medicine and biology, 1999, Volume: 458

    Topics: Adenine; Alkynes; Benzoxazines; Cyclopropanes; Delavirdine; Dideoxynucleosides; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Organophosphonates; Oxazines; Prodrugs; Reverse Transcriptase Inhibitors; Soman; Uracil

1999

Trials

1 trial(s) available for emivirine and uracil

ArticleYear
Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV.
    The New England journal of medicine, 2019, 08-29, Volume: 381, Issue:9

    Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Bone Density; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; Intention to Treat Analysis; Male; Middle Aged; Oxazines; Phosphorous Acids; Piperazines; Pregnancy; Pregnancy Complications, Infectious; Prodrugs; Pyridones; RNA, Viral; Uracil; Viral Load; Young Adult

2019

Other Studies

35 other study(ies) available for emivirine and uracil

ArticleYear
Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:4

    Topics: Antiviral Agents; Cells, Cultured; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Drug Synergism; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Reverse Transcriptase Inhibitors; Uracil; Virus Replication; Zidovudine

1994
The inhibition of human immunodeficiency virus type 1 in vitro by a non-nucleoside reverse transcriptase inhibitor MKC-442, alone and in combination with other anti-HIV compounds.
    Antiviral research, 1995, Volume: 26, Issue:2

    Topics: Antiviral Agents; Cells, Cultured; Cytotoxicity Tests, Immunologic; Didanosine; Drug Interactions; HIV Reverse Transcriptase; HIV-1; Humans; Indolizines; Isoquinolines; Leukocytes, Mononuclear; Molecular Structure; Nevirapine; Pyridines; Quinolines; Reverse Transcriptase Inhibitors; Saquinavir; Uracil; Zalcitabine; Zidovudine

1995
Selective and synergistic inhibition of human immunodeficiency virus type 1 reverse transcriptase by a non-nucleoside inhibitor, MKC-442.
    Molecular pharmacology, 1993, Volume: 44, Issue:4

    Topics: Antiviral Agents; Dideoxynucleotides; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Kinetics; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Uracil; Virus Replication; Zidovudine

1993
Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells.
    Antiviral research, 1996, Volume: 31, Issue:1-2

    Topics: Acetamides; Acetophenones; Cell Line, Transformed; HIV; HIV Core Protein p24; HIV-1; Humans; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Uracil; Zidovudine

1996
Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Nov-12, Volume: 93, Issue:23

    Topics: Base Sequence; Cell Line; DNA Primers; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Point Mutation; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Uracil; Virus Replication

1996
Three-drug combination of MKC-442, lamivudine and zidovudine in vitro: potential approach towards effective chemotherapy against HIV-1.
    AIDS (London, England), 1997, Mar-15, Volume: 11, Issue:4

    Topics: Anti-HIV Agents; Cell Line, Transformed; Cells, Cultured; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Uracil; Zidovudine

1997
Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones.
    Journal of medicinal chemistry, 1998, Jan-15, Volume: 41, Issue:2

    Topics: Alkylation; Anti-HIV Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Magnetic Resonance Spectroscopy; Mesylates; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thiazoles; Thymine; Uracil; Virus Replication

1998
Allosteric inhibitors against HIV-1 reverse transcriptase: design and synthesis of MKC-442 analogues having an omega-functionalized acyclic structure.
    Antiviral chemistry & chemotherapy, 1998, Volume: 9, Issue:4

    Topics: Allosteric Site; Anti-HIV Agents; Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Hydrogen Bonding; Mass Spectrometry; Models, Molecular; Molecular Structure; Reverse Transcriptase Inhibitors; Uracil; Virus Replication

1998
Docking experiments in the flexible non-nucleoside inhibitor binding pocket of HIV-1 reverse transcriptase.
    Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:6

    Topics: Binding Sites; Databases, Factual; HIV; HIV Reverse Transcriptase; Ligands; Molecular Structure; Nevirapine; Protein Conformation; Reproducibility of Results; Reverse Transcriptase Inhibitors; Uracil

1999
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
    Journal of medicinal chemistry, 1999, Nov-04, Volume: 42, Issue:22

    Topics: Animals; Anti-HIV Agents; Cell Line; Crystallography, X-Ray; Drug Design; Drug Resistance, Microbial; HIV-1; Models, Molecular; Molecular Conformation; Mutation; Reverse Transcriptase Inhibitors; Uracil

1999
Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:1

    Topics: Animals; Anti-HIV Agents; Bone Marrow; Dogs; Female; Fetus; Guinea Pigs; HIV-1; Humans; Liver; Macaca fascicularis; Male; Mice; Pregnancy; Rabbits; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Uracil

2000
[The 39th ICAAC (San Francisco) and the 7th European Conference on Clinical Aspects and Treatment of HIV-infection (Lisbon). HIV infection: antiretroviral agents in the development and trial stage].
    Presse medicale (Paris, France : 1983), 2000, Feb-12, Volume: 29, Issue:5

    Topics: Alkynes; Animals; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Oxazines; Quinoxalines; Reverse Transcriptase Inhibitors; Time Factors; Uracil; Viral Load

2000
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.
    AIDS research and human retroviruses, 2000, Apr-10, Volume: 16, Issue:6

    Topics: Alkynes; Anilides; Anti-HIV Agents; Benzoxazines; Cell Line; Cyclopropanes; Delavirdine; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Microbial; Furans; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Mutation; Nevirapine; Oxazines; Quinoxalines; Reverse Transcriptase Inhibitors; Thioamides; Uracil

2000
Estimation of binding affinities for HEPT and nevirapine analogues with HIV-1 reverse transcriptase via Monte Carlo simulations.
    Journal of medicinal chemistry, 2001, Jan-18, Volume: 44, Issue:2

    Topics: Anti-HIV Agents; HIV Reverse Transcriptase; Models, Molecular; Monte Carlo Method; Nevirapine; Protein Binding; Pyrimidinones; Regression Analysis; Reverse Transcriptase Inhibitors; Thermodynamics; Uracil

2001
Prediction of activity for nonnucleoside inhibitors with HIV-1 reverse transcriptase based on Monte Carlo simulations.
    Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14

    Topics: Alkynes; Anilides; Benzoxazines; Computer Simulation; Cyclopropanes; HIV Reverse Transcriptase; Hydrogen Bonding; Models, Molecular; Monte Carlo Method; Nevirapine; Oxazines; Protein Binding; Quinoxalines; Regression Analysis; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil

2002
Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants.
    Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26

    Topics: Anti-HIV Agents; Cell Line; HIV-1; Humans; Magnetic Resonance Spectroscopy; Mutation; Stereoisomerism; Structure-Activity Relationship; Uracil; Virus Replication

2002
Synthesis of novel MKC-442 analogues with potent activities against HIV-1.
    Archiv der Pharmazie, 2003, Volume: 336, Issue:4-5

    Topics: Anti-HIV Agents; Cell Line; HIV-1; Humans; Structure-Activity Relationship; Uracil; Virus Replication

2003
Three-drug combinations of emivirine and nucleoside reverse transcriptase inhibitors in vitro: long-term culture of HIV-1-infected cells and breakthrough viruses.
    Antiviral chemistry & chemotherapy, 2001, Volume: 12, Issue:3

    Topics: Anti-HIV Agents; Cell Line; Didanosine; Drug Combinations; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Nucleosides; Reverse Transcriptase Inhibitors; Stavudine; Uracil; Virus Replication

2001
Multiple pathways in the synthesis of new annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (emivirine).
    Organic & biomolecular chemistry, 2003, Aug-21, Volume: 1, Issue:16

    Topics: Anti-HIV Agents; Cell Line, Transformed; Cyclization; HIV-1; Humans; Molecular Conformation; Structure-Activity Relationship; Uracil

2003
Synthesis and evaluation of new potential HIV-1 non-nucleoside reverse transcriptase inhibitors. New analogues of MKC-442 containing Michael acceptors in the C-6 position.
    Organic & biomolecular chemistry, 2003, Oct-21, Volume: 1, Issue:20

    Topics: Anti-HIV Agents; Cell Line; Drug Evaluation, Preclinical; HIV Reverse Transcriptase; HIV-1; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Uracil

2003
Synthesis of 6-arylvinyl analogues of the HIV drugs SJ-3366 and Emivirine.
    Bioorganic & medicinal chemistry, 2004, Mar-01, Volume: 12, Issue:5

    Topics: Anti-HIV Agents; Cell Line, Transformed; HIV-1; Humans; Inhibitory Concentration 50; Mutation, Missense; Pyrimidinones; Structure-Activity Relationship; Uracil; Virus Replication

2004
Synthesis of furoannelated analogues of Emivirine (MKC-442).
    Archiv der Pharmazie, 2004, Volume: 337, Issue:3

    Topics: Cell Line; HIV-1; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil

2004
4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.
    Journal of medicinal chemistry, 2004, Oct-21, Volume: 47, Issue:22

    Topics: Alkynes; Aminopyridines; Anti-HIV Agents; Benzene Derivatives; Benzoates; Benzoxazines; Cell Line; Cyclopropanes; HIV-1; Humans; Mutagenesis, Site-Directed; Mutation; Nevirapine; Oxazines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil

2004
Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach.
    Journal of medicinal chemistry, 2005, Feb-24, Volume: 48, Issue:4

    Topics: Cell Line; Drug Resistance, Viral; HIV-1; HIV-2; Humans; Mutation; Prodrugs; Reverse Transcriptase Inhibitors; Stavudine; Stereoisomerism; Structure-Activity Relationship; Sulfides; Thymidine Monophosphate; Uracil

2005
Chemo- and regioselective functionalization of uracil derivatives. Applications to the synthesis of oxypurinol and emivirine.
    Organic letters, 2006, Aug-17, Volume: 8, Issue:17

    Topics: Catalysis; Combinatorial Chemistry Techniques; Indicators and Reagents; Molecular Structure; Oxypurinol; Uracil

2006
The design and synthesis of 9-phenylcyclohepta[d]pyrimidine-2,4-dione derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase.
    Organic & biomolecular chemistry, 2006, Sep-07, Volume: 4, Issue:17

    Topics: Anti-HIV Agents; Binding Sites; Crystallography, X-Ray; Cycloheptanes; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; Uracil

2006
Synthesis and anti-HIV-1 activity of new MKC-442 analogues with an alkynyl-substituted 6-benzyl group.
    Archiv der Pharmazie, 2007, Volume: 340, Issue:5

    Topics: Anti-HIV Agents; Cell Line; Cell Survival; HIV-1; Humans; Mutation; Structure-Activity Relationship; Uracil; Virus Replication

2007
Synthesis and antiviral activity of new dimeric inhibitors against HIV-1.
    Bioorganic & medicinal chemistry, 2008, Jan-01, Volume: 16, Issue:1

    Topics: Anti-HIV Agents; Dimerization; HIV-1; Humans; Mutation; Pyrimidines; Uracil; Zidovudine

2008
Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186.
    Archiv der Pharmazie, 2008, Volume: 341, Issue:1

    Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil

2008
Synthesis and anti-HIV-1 activity of 1-substiuted 6-(3-cyanobenzoyl) and [(3-cyanophenyl)fluoromethyl]-5-ethyl-uracils.
    Archiv der Pharmazie, 2009, Volume: 342, Issue:9

    Topics: Anti-HIV Agents; Cell Line; Cell Survival; Diethylamines; Drug Evaluation, Preclinical; Drug Resistance, Viral; Fluorine; HIV Reverse Transcriptase; HIV-1; Molecular Structure; Mutation; Reverse Transcriptase Inhibitors; Uracil

2009
Synthesis of novel uracil non-nucleoside derivatives as potential reverse transcriptase inhibitors of HIV-1.
    Archiv der Pharmazie, 2009, Volume: 342, Issue:11

    Topics: Anti-HIV Agents; HIV-1; Reverse Transcriptase Inhibitors; Uracil

2009
Theoretical studies on the molecular basis of HIV-1RT/NNRTIs interactions.
    Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:1

    Topics: Alkynes; Amino Acids; Benzoxazines; Binding Sites; Cyclopropanes; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Models, Biological; Molecular Dynamics Simulation; Mutation; Nevirapine; Nitriles; Protein Binding; Protein Conformation; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Thermodynamics; Uracil; Water

2011
Epigallocatechin gallate inhibits the HIV reverse transcription step.
    Antiviral chemistry & chemotherapy, 2011, Jul-04, Volume: 21, Issue:6

    Topics: Anti-HIV Agents; Catechin; Drug Evaluation, Preclinical; Drug Synergism; HeLa Cells; HIV Infections; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Reverse Transcriptase Inhibitors; Reverse Transcription; Uracil; Zidovudine

2011
Synthesis of novel fluoro analogues of MKC442 as microbicides.
    Journal of medicinal chemistry, 2014, Jun-26, Volume: 57, Issue:12

    Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Pyrimidinones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil

2014
Synthesis and Antiviral Evaluation of 1-[(2-Phenoxyethyl)oxymethyl] and 6-(3,5-Dimethoxybenzyl) Analogues of HIV Drugs Emivirine and TNK-651.
    Drug research, 2016, Volume: 66, Issue:4

    Topics: Anti-HIV Agents; Cell Line; HIV-1; Microbial Sensitivity Tests; Molecular Structure; Mutation; Pyrimidines; Structure-Activity Relationship; Uracil

2016