emetine and cyclosporine

Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors

Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity

Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

Topics: Bucladesine; CD4 Antigens; CD8 Antigens; Cholera Toxin; Cycloheximide; Cyclosporine; Cytotoxicity, Immunologic; Dactinomycin; Egtazic Acid; Emetine; Humans; Lymphocyte Activation; Mitomycin; T-Lymphocyte Subsets; Tumor Necrosis Factor-alpha

Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Death; Cisplatin; Cycloheximide; Cyclosporine; Doxorubicin; Drug Interactions; Drug Resistance; Emetine; Female; Humans; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil

Topics: Base Sequence; Calcimycin; Calcium; CD8 Antigens; Cell Adhesion; Cyclosporine; Emetine; Gene Expression; Granzymes; Humans; Interleukin-2; Leukocytes, Mononuclear; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Perforin; Pore Forming Cytotoxic Proteins; RNA, Messenger; Serine Endopeptidases; T-Lymphocyte Subsets; Tetradecanoylphorbol Acetate; Time Factors

Topics: Animals; Biotin; Cyclosporine; Deoxyuracil Nucleotides; DNA Replication; Emetine; Flow Cytometry; Humans; Male; Mice; Mice, Inbred Strains; Microscopy, Fluorescence; T-Lymphocytes; Thymus Gland; Tumor Cells, Cultured

Topics: Antigens, Surface; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Clone Cells; Cyclosporine; Cytotoxicity, Immunologic; Emetine; Fas Ligand Protein; fas Receptor; Humans; Immunosuppressive Agents; Interleukin-2; Membrane Glycoproteins; Receptors, Antigen, T-Cell; T-Lymphocytes, Cytotoxic; Th1 Cells; Th2 Cells

Topics: Aurovertins; Cyclosporine; Cytochrome c Group; Cytosol; Deoxyglucose; Emetine; Enzyme Inhibitors; Genes, bcl-2; HeLa Cells; Humans; Ion Channels; Membrane Potentials; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neoplasm Proteins; Oligomycins; Proto-Oncogene Proteins c-bcl-2; Proton-Translocating ATPases; Recombinant Fusion Proteins; Recombinant Proteins; Staurosporine; Transfection; Tumor Necrosis Factor-alpha; Uncoupling Agents