emd 53998 has been researched along with pimobendan in 12 studies
| Studies (emd 53998) | Trials (emd 53998) | Recent Studies (post-2010) (emd 53998) | Studies (pimobendan) | Trials (pimobendan) | Recent Studies (post-2010) (pimobendan) |
|---|---|---|---|---|---|
| 112 | 0 | 9 | 348 | 67 | 101 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (75.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beier, N; Haeusler, G; Harting, J; Jonas, R; Klockow, M; Lues, I | 1 |
| Allen, DG; Lee, JA | 1 |
| Etemadzadeh, E; Haikala, H; Levijoki, J; Lindén, IB; Nissinen, E | 1 |
| Haikala, H; Levijoki, J; Lindén, IB | 1 |
| Abe, Y; Ishisu, R; Nakano, T; Onishi, K; Sekioka, K; Ueda, Y | 1 |
| Haikala, H; Linden, IB | 1 |
| Holubarsch, C | 1 |
| Duncker, DJ; Haitsma, DB; Stubenitsky, R; van der Weerd, RW; Verdouw, PD | 1 |
| Bodi, A; Edes, I; Facsko, A; Kovacs, L; Kranias, EG; Kristof, E; Papp, JG; Papp, Z; Szigeti, G | 1 |
| Duncker, DJ; Haitsma, DB; Heins, N; Liem, DA; Stubenitsky, R; Verdouw, PD | 1 |
| Brixius, K; Schwinger, RH | 1 |
| Endoh, M | 1 |
3 review(s) available for emd 53998 and pimobendan
| Article | Year |
|---|---|
Mechanisms of action of calcium-sensitizing drugs.
Topics: Animals; Calcium; Cardiotonic Agents; Humans; Hydrazones; Myocardial Contraction; Pyridazines; Quinolines; Sensitivity and Specificity; Simendan; Thiadiazines; Troponin C | 1995 |
[If the myofilaments become sensitive: Ca2+-sensitizer for the therapy of heart insufficiency].
Topics: Actin Cytoskeleton; Calcium; Cardiotonic Agents; Heart; Heart Failure; Humans; Hydrazones; Myocardium; Oxygen Consumption; Pyridazines; Quinolines; Simendan; Thiadiazines | 2005 |
Cardiac Ca2+ signaling and Ca2+ sensitizers.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Angiotensin II; Animals; Azocines; Calcium; Calcium Signaling; Cardiotonic Agents; Cholinergic Agonists; Dihydropyridines; Endothelins; Heart Failure; Humans; Hydrazones; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyridazines; Quinolines; Simendan; Thiadiazines; Troponin C | 2008 |
9 other study(ies) available for emd 53998 and pimobendan
| Article | Year |
|---|---|
The novel cardiotonic agent EMD 53 998 is a potent "calcium sensitizer".
Topics: Adenosine Triphosphatases; Animals; Calcium; Carbachol; Cardiotonic Agents; Cattle; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Isoenzymes; Isometric Contraction; Isoproterenol; Male; Myocardial Contraction; Myocardium; Myofibrils; Papillary Muscles; Phosphoric Diester Hydrolases; Pyridazines; Quinolines; Rats; Rats, Inbred Strains; Thiadiazines | 1991 |
EMD 53998 sensitizes the contractile proteins to calcium in intact ferret ventricular muscle.
Topics: Animals; Calcium; Cardiotonic Agents; Contractile Proteins; Ferrets; Heart Ventricles; Hypoxia; In Vitro Techniques; Intracellular Membranes; Models, Cardiovascular; Muscles; Myocardial Contraction; Pyridazines; Quinolines; Thiadiazines | 1991 |
Troponin C-mediated calcium sensitization induced by levosimendan does not impair relaxation.
Topics: Adenosine Triphosphatases; Animals; Calcium; Cardiac Pacing, Artificial; Cardiotonic Agents; Cell Membrane; Female; Guinea Pigs; Hydrazones; Hydrogen-Ion Concentration; Male; Myocardial Contraction; Myofibrils; Papillary Muscles; Pyridazines; Quinolines; Simendan; Thiadiazines; Troponin; Troponin C; Vasodilator Agents | 1995 |
Troponin C-mediated calcium sensitization by levosimendan accelerates the proportional development of isometric tension.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Actomyosin; Animals; Calcium; Cardiotonic Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Guinea Pigs; Hydrazones; Isometric Contraction; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridazines; Quinolines; Simendan; Thiadiazines; Troponin; Troponin C | 1995 |
Restoration of ischemic contractile failure of indo-1-loaded guinea pig heart by a calcium sensitizer, MCI-154.
Topics: Animals; Calcium; Cardiotonic Agents; Guinea Pigs; Indoles; Male; Myocardial Contraction; Myocardial Ischemia; Perfusion; Pyridazines; Quinolines; Thiadiazines; Ventricular Function, Left | 1996 |
New inotropic concepts: rationale for and differences between calcium sensitizers and phosphodiesterase inhibitors.
Topics: Animals; Calcium; Cardiotonic Agents; Deoxyepinephrine; Energy Metabolism; Guinea Pigs; Heart Failure; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Quinolines; Thiadiazines | 1997 |
Cardiovascular effects of the novel Ca2+-sensitiser EMD 57033 in pigs at rest and during treadmill exercise.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Cardiovascular System; Coronary Circulation; Dose-Response Relationship, Drug; Female; Hemodynamics; Male; Phosphodiesterase Inhibitors; Physical Conditioning, Animal; Pulmonary Circulation; Pyridazines; Quinolines; Rest; Swine; Thiadiazines; Vascular Resistance | 1997 |
Cardiac responses to calcium sensitizers and isoproterenol in intact guinea pig hearts. Effects on cyclic AMP levels, protein phosphorylation, myoplasmic calcium concentration, and left ventricular function.
Topics: Animals; Calcium; Cardiotonic Agents; Cyclic AMP; Guinea Pigs; Heart; Hydrazones; Isoproterenol; Muscle Proteins; Myocardium; Phosphorylation; Pyridazines; Quinolines; Simendan; Thiadiazines; Ventricular Function, Left | 1998 |
Beneficial effects of the Ca2+ sensitizer EMD 57033 in exercising pigs with infarction-induced chronic left ventricular dysfunction.
Topics: Animals; Calcium; Cardiotonic Agents; Chronic Disease; Exercise Test; Female; Hemodynamics; Male; Myocardial Infarction; Pyridazines; Quinolines; Swine; Thiadiazines; Ventricular Dysfunction, Left | 2001 |