Compounds > em 523
Page last updated: 2024-09-05

em 523 and erythromycin

em 523 has been researched along with erythromycin in 23 studies

Compound Research Comparison

Studies
(em 523)		Trials
(em 523)		Recent Studies (post-2010)
(em 523)		Studies
(erythromycin)		Trials
(erythromycin)		Recent Studies (post-2010) (erythromycin)
261014,5241,1381,926

Protein Interaction Comparison

ProteinTaxonomyem 523 (IC50)erythromycin (IC50)
30S ribosomal protein S6Escherichia coli K-121.156
30S ribosomal protein S7Escherichia coli K-121.156
50S ribosomal protein L15Escherichia coli K-121.156
Cytochrome P450 3A4Homo sapiens (human)1.045
50S ribosomal protein L10Escherichia coli K-121.156
50S ribosomal protein L11Escherichia coli K-121.156
50S ribosomal protein L7/L12Escherichia coli K-121.156
50S ribosomal protein L19Escherichia coli K-121.156
50S ribosomal protein L1Escherichia coli K-121.156
50S ribosomal protein L20Escherichia coli K-121.156
50S ribosomal protein L27Escherichia coli K-121.156
50S ribosomal protein L28Escherichia coli K-121.156
50S ribosomal protein L29Escherichia coli K-121.156
50S ribosomal protein L31Escherichia coli K-121.156
50S ribosomal protein L31 type BEscherichia coli K-121.156
50S ribosomal protein L32Escherichia coli K-121.156
50S ribosomal protein L33Escherichia coli K-121.156
50S ribosomal protein L34Escherichia coli K-121.156
50S ribosomal protein L35Escherichia coli K-121.156
50S ribosomal protein L36Escherichia coli K-121.156
30S ribosomal protein S10Escherichia coli K-121.156
30S ribosomal protein S11Escherichia coli K-121.156
30S ribosomal protein S12Escherichia coli K-121.156
30S ribosomal protein S13Escherichia coli K-121.156
30S ribosomal protein S16Escherichia coli K-121.156
30S ribosomal protein S18Escherichia coli K-121.156
30S ribosomal protein S19Escherichia coli K-121.156
30S ribosomal protein S20Escherichia coli K-121.156
30S ribosomal protein S2Escherichia coli K-121.156
30S ribosomal protein S3Escherichia coli K-121.156
30S ribosomal protein S4Escherichia coli K-121.156
30S ribosomal protein S5Escherichia coli K-121.156
30S ribosomal protein S8Escherichia coli K-121.156
30S ribosomal protein S9Escherichia coli K-121.156
50S ribosomal protein L13Escherichia coli K-121.156
50S ribosomal protein L14Escherichia coli K-121.156
50S ribosomal protein L16Escherichia coli K-121.156
50S ribosomal protein L23Escherichia coli K-121.156
30S ribosomal protein S15Escherichia coli K-121.156
50S ribosomal protein L17Escherichia coli K-121.156
50S ribosomal protein L21Escherichia coli K-121.156
50S ribosomal protein L30Escherichia coli K-121.156
50S ribosomal protein L6Escherichia coli K-121.156
30S ribosomal protein S14Escherichia coli K-121.156
30S ribosomal protein S17Escherichia coli K-121.156
30S ribosomal protein S1Escherichia coli K-121.156
50S ribosomal protein L18Escherichia coli K-121.156
50S ribosomal protein L2Escherichia coli K-121.156
50S ribosomal protein L3Escherichia coli K-121.156
50S ribosomal protein L24Escherichia coli K-121.156
50S ribosomal protein L4Escherichia coli K-121.156
50S ribosomal protein L22Escherichia coli K-121.156
50S ribosomal protein L5Escherichia coli K-121.156
30S ribosomal protein S21Escherichia coli K-121.156
50S ribosomal protein L25Escherichia coli K-121.156
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.039
50S ribosomal protein L36 2Escherichia coli K-121.156

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.35)18.7374
1990's20 (86.96)18.2507
2000's2 (8.70)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Edwards, CM; Faghih, R; Freiberg, L; Klein, LL; Lartey, PA; Marsh, K; Nellans, HN; Petersen, A; Plattner, JJ; Quigley, S1
Ito, Z; Kondo, Y; Mizumoto, A; Omura, S; Otawa, M1
Matthijs, G; Peeters, TL; Vantrappen, G1
Inatomi, N; Itoh, Z; Marui, S; Omura, S; Satoh, H; Satoh, T1
Hashimoto, N; Inatomi, N; Itoh, Z; Maki, Y; Omura, S; Satoh, H1
Haga, N; Inatomi, N; Itoh, Z; Mizumoto, A; Shiba, Y; Yamamoto, O1
Tanaka, H1
Inatomi, N; Itoh, Z; Omura, S; Satoh, H; Satoh, T1
Depoortere, I; Dharanipragada, R; Florance, JR; Galdes, A; Macielag, MJ; Marvin, MS; Peeters, TL1
Motohashi, M; Yamashita, K; Yashiki, T1
Hayashi, N; Itoh, Z; Mizumoto, A; Ohtawa, M; Omura, S; Yanagida, K1
Itoh, Z; Kawamura, O; Omura, S; Sekiguchi, T1
Inui, A; Itoh, Z; Mizumoto, A; Omura, S; Satoh, M; Shiba, Y1
Funabashi, Y; Harada, S; Inatomi, N; Itoh, Z; Maeshiba, Y; Omura, S; Tanayama, S1
Funabashi, Y; Hakoda, S; Harada, S; Inatomi, N; Itoh, Z; Koyama, K; Omura, S; Tanida, S1
Inatomi, N; Mizuki, A; Sato, S; Shiba, Y; Yamamoto, O1
Aoyama, N; Baba, S; Inui, A; Kasuga, M; Miyamoto, M; Morimoto, S; Nakajima, Y; Ohmoto, A; Okano, H; Ueno, N1
Aoki, I; Monji, H; Ueno, H; Yamaguchi, M1
Haga, N; Itoh, Z; Mizumoto, A; Tanaka, T1
Baba, T; Ishii, M; Kasai, F; Nakamura, T; Takebe, K1
Kitazawa, T; Ohga, A; Taneike, T1
Itoh, Z; Koga, H; Omura, S; Ozaki, K; Takanashi, H; Yogo, K1
Akima, M; Itoh, Z; Kamei, K; Koga, H; Omura, S; Onoma, M; Ozaki, K; Sudo, H; Takanashi, H; Yogo, K1

Reviews

1 review(s) available for em 523 and erythromycin

ArticleYear
[Receptor agonists and antagonists: the present and future].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1993, Volume: 38, Issue:11

    Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Benzodiazepinones; Biphenyl Compounds; Cholinergic Antagonists; Devazepide; Erythromycin; Imidazoles; Ligands; Losartan; Peptides; Receptors, Cholecystokinin; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Tetrazoles

1993

Trials

1 trial(s) available for em 523 and erythromycin

ArticleYear
Erythromycin derivative improves gastric emptying and insulin requirement in diabetic patients with gastroparesis.
    Diabetes care, 1997, Volume: 20, Issue:7

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Biomarkers; Diabetes Mellitus, Type 1; Erythromycin; Female; Gastric Emptying; Gastrointestinal Agents; Gastroparesis; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Male; Middle Aged; Postprandial Period; Time Factors

1997

Other Studies

21 other study(ies) available for em 523 and erythromycin

ArticleYear
Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate.
    Journal of medicinal chemistry, 1995, May-12, Volume: 38, Issue:10

    Topics: Administration, Oral; Animals; Biological Availability; Dogs; Erythromycin; Female; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle, Smooth; Rabbits

1995
[Effect of motilin agonist, EM-523 on gastrointestinal motility].
    Nihon Geka Gakkai zasshi, 1991, Volume: 92, Issue:9

    Topics: Animals; Dogs; Erythromycin; Gastrointestinal Motility; Motilin

1991
Ca2+ dependence of motilide-induced contractions in rabbit duodenal muscle strips in vitro.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:2

    Topics: Animals; Calcium; Duodenum; Erythromycin; In Vitro Techniques; Molecular Structure; Motilin; Muscle Contraction; Muscle, Smooth; Rabbits

1991
EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Dinoprost; Drug Interactions; Erythromycin; Female; Guinea Pigs; Intestine, Small; Male; Motilin; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Tetrodotoxin

1990
An erythromycin derivative, EM-523, induces motilin-like gastrointestinal motility in dogs.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:2

    Topics: Animals; Atropine; Dogs; Erythromycin; Fasting; Gastrointestinal Motility; Male; Motilin; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Vomiting

1989
Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs.
    Gastroenterology, 1995, Volume: 109, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Atropine; Dipeptides; Dogs; Dopamine; Eating; Erythromycin; Hexamethonium; Indoles; Motilin; Muscle Contraction; Naloxone; Ondansetron; Serotonin Antagonists; Stomach; Substance P

1995
Comparison of the motor-stimulating action of EM523, an erythromycin derivative, and prostaglandin F2 alpha in conscious dogs.
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:2

    Topics: Animals; Atropine; Dinoprost; Dogs; Dopamine; Erythromycin; Fasting; Gastrointestinal Motility; Male; Motilin

1993
The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit.
    Biochemical and biophysical research communications, 1994, Jan-28, Volume: 198, Issue:2

    Topics: Animals; Binding, Competitive; Digestive System; Duodenum; Erythromycin; Motilin; Muscle Contraction; Muscle, Smooth; Pyloric Antrum; Rabbits

1994
Sensitive high-performance liquid chromatographic determination of EM523, a new erythromycin derivative, in human plasma and urine with ultraviolet detection using column switching.
    Journal of chromatography, 1993, Jun-23, Volume: 616, Issue:1

    Topics: Chromatography, High Pressure Liquid; Electrochemistry; Erythromycin; Humans; Indicators and Reagents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

1993
Mechanism of gastroprokinetic effect of EM523, an erythromycin derivative, in dogs.
    Gastroenterology, 1993, Volume: 104, Issue:5

    Topics: Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Erythromycin; Female; Gastrointestinal Motility; Immune Sera; Male; Motilin

1993
Effect of erythromycin derivative EM523L on human interdigestive gastrointestinal tract.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:6

    Topics: Adult; Digestion; Digestive System; Digestive System Physiological Phenomena; Dose-Response Relationship, Drug; Erythromycin; Gastrointestinal Motility; Humans; Male; Motilin; Reference Values; Time Factors

1993
Effect of nonpeptide motilin agonist EM523 on release of gut and pancreatic hormones in conscious dogs.
    Gastroenterology, 1996, Volume: 110, Issue:1

    Topics: Animals; Atropine; Dogs; Erythromycin; Gastrointestinal Hormones; Motilin; Ondansetron; Pancreatic Hormones; Serotonin Antagonists; Vagotomy

1996
Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity.
    The Journal of antibiotics, 1996, Volume: 49, Issue:8

    Topics: Animals; Dogs; Erythromycin; Gastrointestinal Agents; Gastrointestinal Motility; In Vitro Techniques; Male; Rabbits

1996
Microbial conversion of EM574 and EM523, gastrointestinal motor stimulating agents.
    The Journal of antibiotics, 1996, Volume: 49, Issue:8

    Topics: Actinomycetales; Animals; Dogs; Erythromycin; Gastrointestinal Agents; Gastrointestinal Motility; In Vitro Techniques; Rabbits

1996
[Mechanism of increased gastric motility effect of EM523].
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 1995, Volume: 31, Issue:6

    Topics: Animals; Dogs; Dose-Response Relationship, Drug; Eating; Erythromycin; Gastrointestinal Agents; Gastrointestinal Motility; Muscle Contraction; Muscle, Smooth; Stomach

1995
EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion.
    Peptides, 1996, Volume: 17, Issue:6

    Topics: Adult; Aged; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Erythromycin; Evaluation Studies as Topic; Female; Gastric Emptying; Gastrointestinal Agents; Humans; Male; Middle Aged; Motilin; Pancreatic Polypeptide

1996
Highly sensitive high-performance liquid chromatographic determination method for a new erythromycin derivative, EM523, and its major metabolites in human plasma and urine using post-column tris(2,2'-bipyridine) ruthenium(III) chemiluminescence detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Mar-07, Volume: 690, Issue:1-2

    Topics: 2,2'-Dipyridyl; Chromatography, High Pressure Liquid; Erythromycin; Gastrointestinal Agents; Humans; Luminescent Measurements; Organometallic Compounds; Sensitivity and Specificity

1997
A new method to measure gastric emptying in conscious dogs: a validity study and effects of EM523 and L-NNA.
    The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 1

    Topics: Animals; Dogs; Enzyme Inhibitors; Erythromycin; Evaluation Studies as Topic; Gastric Emptying; Gastroenterology; Gastrointestinal Agents; Motor Activity; Nitroarginine; Reference Values; Stomach; Time Factors

1997
Functional characterization of neural and smooth muscle motilin receptors in the chicken proventriculus and ileum.
    Regulatory peptides, 1997, Aug-15, Volume: 71, Issue:2

    Topics: Animals; Chickens; Dogs; Erythromycin; Gastrointestinal Agents; Hormones; Ileum; Motilin; Muscle Contraction; Muscle, Smooth; Proventriculus; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Swine

1997
In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine.
    Pharmacology, 2007, Volume: 79, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Calcium Chloride; Diltiazem; Dose-Response Relationship, Drug; Erythromycin; Hexamethonium; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Intestine, Small; Male; Molecular Structure; Muscle Contraction; Muscle, Smooth; Naloxone; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Tetrodotoxin; Tropisetron; Verapamil

2007
Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs.
    Pharmacology, 2007, Volume: 79, Issue:4

    Topics: Administration, Oral; Animals; Digestion; Dogs; Dose-Response Relationship, Drug; Erythromycin; Female; Gastrointestinal Agents; Gastrointestinal Tract; Injections, Intravenous; Male; Motilin; Muscle Contraction; Muscle, Smooth; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide

2007