em 523 has been researched along with atropine in 7 studies
| Studies (em 523) | Trials (em 523) | Recent Studies (post-2010) (em 523) | Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) |
|---|---|---|---|---|---|
| 26 | 1 | 0 | 26,711 | 1,259 | 1,697 |
| Protein | Taxonomy | em 523 (IC50) | atropine (IC50) |
|---|---|---|---|
| cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | 21.41 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 1.012 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.0067 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0007 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.001 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.001 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.001 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.001 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.0009 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.001 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.0015 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.0021 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.354 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 1.012 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inatomi, N; Itoh, Z; Marui, S; Omura, S; Satoh, H; Satoh, T | 1 |
| Hashimoto, N; Inatomi, N; Itoh, Z; Maki, Y; Omura, S; Satoh, H | 1 |
| Haga, N; Inatomi, N; Itoh, Z; Mizumoto, A; Shiba, Y; Yamamoto, O | 1 |
| Inatomi, N; Itoh, Z; Omura, S; Satoh, H; Satoh, T | 1 |
| Hayashi, N; Itoh, Z; Mizumoto, A; Ohtawa, M; Omura, S; Yanagida, K | 1 |
| Inui, A; Itoh, Z; Mizumoto, A; Omura, S; Satoh, M; Shiba, Y | 1 |
| Itoh, Z; Koga, H; Omura, S; Ozaki, K; Takanashi, H; Yogo, K | 1 |
7 other study(ies) available for em 523 and atropine
| Article | Year |
|---|---|
EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine.
Topics: Acetylcholine; Animals; Atropine; Dinoprost; Drug Interactions; Erythromycin; Female; Guinea Pigs; Intestine, Small; Male; Motilin; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Tetrodotoxin | 1990 |
An erythromycin derivative, EM-523, induces motilin-like gastrointestinal motility in dogs.
Topics: Animals; Atropine; Dogs; Erythromycin; Fasting; Gastrointestinal Motility; Male; Motilin; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Vomiting | 1989 |
Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs.
Topics: Animals; Anti-Bacterial Agents; Atropine; Dipeptides; Dogs; Dopamine; Eating; Erythromycin; Hexamethonium; Indoles; Motilin; Muscle Contraction; Naloxone; Ondansetron; Serotonin Antagonists; Stomach; Substance P | 1995 |
Comparison of the motor-stimulating action of EM523, an erythromycin derivative, and prostaglandin F2 alpha in conscious dogs.
Topics: Animals; Atropine; Dinoprost; Dogs; Dopamine; Erythromycin; Fasting; Gastrointestinal Motility; Male; Motilin | 1993 |
Mechanism of gastroprokinetic effect of EM523, an erythromycin derivative, in dogs.
Topics: Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Erythromycin; Female; Gastrointestinal Motility; Immune Sera; Male; Motilin | 1993 |
Effect of nonpeptide motilin agonist EM523 on release of gut and pancreatic hormones in conscious dogs.
Topics: Animals; Atropine; Dogs; Erythromycin; Gastrointestinal Hormones; Motilin; Ondansetron; Pancreatic Hormones; Serotonin Antagonists; Vagotomy | 1996 |
In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine.
Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Calcium Chloride; Diltiazem; Dose-Response Relationship, Drug; Erythromycin; Hexamethonium; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Intestine, Small; Male; Molecular Structure; Muscle Contraction; Muscle, Smooth; Naloxone; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Tetrodotoxin; Tropisetron; Verapamil | 2007 |